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Conserved domains on  [gi|1144540820|gb|ONV91016|]
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glycosyl transferase [Burkholderia cenocepacia]

Protein Classification

glycosyltransferase family 4 protein( domain architecture ID 10133505)

glycosyltransferase family 4 (GT4) protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds

CAZY:  GT4
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
PubMed:  12691742|10521532|16037492
SCOP:  3001586

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-339 2.30e-148

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


:

Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 421.70  E-value: 2.30e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPLHEAVPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQV 81
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRLDPIPQESKLAELLEALEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  82 RRRAEEFDVLHCHIDYYPFSLFSRQPVPHLTTMHGRLDLPELqPIFNAFSDVPVVSISDNQRIPLPQANWLSTVYHGLPE 161
Cdd:cd03802    81 QLRASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPSIPPSL-AIYAAEPPVNYVSISDAQRAATPPIDYLTVVHNGLDP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 162 NLLTPIPNVKPsYLAFLGRISPEKRVDTAIRIAEQAGLPIKIAAKLDKADRAYYEEKIKPLfalPHVEYIGEISESEKTE 241
Cdd:cd03802   160 ADYRFQPDPED-YLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLPG---PRIEFIGEVGHDEKQE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 242 FLGNAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAALKRLDTLPREKVRAAFEA 321
Cdd:cd03802   236 LLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRAACRRYAED 315

                         330
                  ....*....|....*...
gi 1144540820 322 RFSSKVMAQNYVKGYEEL 339
Cdd:cd03802   316 RFSAARMADRYEALYRKV 333
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-339 2.30e-148

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 421.70  E-value: 2.30e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPLHEAVPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQV 81
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRLDPIPQESKLAELLEALEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  82 RRRAEEFDVLHCHIDYYPFSLFSRQPVPHLTTMHGRLDLPELqPIFNAFSDVPVVSISDNQRIPLPQANWLSTVYHGLPE 161
Cdd:cd03802    81 QLRASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPSIPPSL-AIYAAEPPVNYVSISDAQRAATPPIDYLTVVHNGLDP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 162 NLLTPIPNVKPsYLAFLGRISPEKRVDTAIRIAEQAGLPIKIAAKLDKADRAYYEEKIKPLfalPHVEYIGEISESEKTE 241
Cdd:cd03802   160 ADYRFQPDPED-YLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLPG---PRIEFIGEVGHDEKQE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 242 FLGNAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAALKRLDTLPREKVRAAFEA 321
Cdd:cd03802   236 LLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRAACRRYAED 315

                         330
                  ....*....|....*...
gi 1144540820 322 RFSSKVMAQNYVKGYEEL 339
Cdd:cd03802   316 RFSAARMADRYEALYRKV 333
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 171-310 3.25e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 96.96  E-value: 3.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 171 KPSYLAFLGRISPEKRVDTAIRIAEQ---AGLPIKIAAKLDKADRAYYEEKIKPLFALPHVEYIGEISESEKTEFLGNAH 247
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALlkeKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1144540820 248 ALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDElSAVAALKRLDTL 310
Cdd:pfam00534  81 VFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPN-NAEALAEAIDKL 141
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 242-341 2.85e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 87.74  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 242 FLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAALKRLDTLP------RE 313
Cdd:COG0438    17 LLAAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLEDPelrrrlGE 95

                          90       100
                  ....*....|....*....|....*...
gi 1144540820 314 KVRAAFEARFSSKVMAQNYVKGYEELLR 341
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALYEELLA 123
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 257-340 2.14e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 52.03  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 257 EPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVV--EDELSAVAALKRLDTLPREKV------RAAFEARFSSKVM 328
Cdd:TIGR03088 283 EGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVppGDAVALARALQPYVSDPAARRahgaagRARAEQQFSINAM 362

                          90
                  ....*....|..
gi 1144540820 329 AQNYVKGYEELL 340
Cdd:TIGR03088 363 VAAYAGLYDQLL 374
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
175-300 2.21e-07

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 52.10  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 175 LAFLGRISPEKRVDTAIRIAEQ---AGLPIKIAAKLD-----KADRAYYEEKIKPLFAL--PHVEYIGEISESEKTEFLG 244
Cdd:PRK15484  196 LLYAGRISPDKGILLLMQAFEKlatAHSNLKLVVVGDptassKGEKAAYQKKVLEAAKRigDRCIMLGGQPPEKMHNYYP 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1144540820 245 NAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSA 300
Cdd:PRK15484  276 LADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTS 331
 
Name Accession Description Interval E-value
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 2-339 2.30e-148

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 421.70  E-value: 2.30e-148
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPLHEAVPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQV 81
Cdd:cd03802     1 RIAQVSPPRGPVPPGKYGGTELVVSALTEGLVRRGHEVTLFAPGDSHTSAPLVAVIPRALRLDPIPQESKLAELLEALEV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  82 RRRAEEFDVLHCHIDYYPFSLFSRQPVPHLTTMHGRLDLPELqPIFNAFSDVPVVSISDNQRIPLPQANWLSTVYHGLPE 161
Cdd:cd03802    81 QLRASDFDVIHNHSYDWLPPFAPLIGTPFVTTLHGPSIPPSL-AIYAAEPPVNYVSISDAQRAATPPIDYLTVVHNGLDP 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 162 NLLTPIPNVKPsYLAFLGRISPEKRVDTAIRIAEQAGLPIKIAAKLDKADRAYYEEKIKPLfalPHVEYIGEISESEKTE 241
Cdd:cd03802   160 ADYRFQPDPED-YLAFLGRIAPEKGLEDAIRVARRAGLPLKIAGKVRDEDYFYYLQEPLPG---PRIEFIGEVGHDEKQE 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 242 FLGNAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAALKRLDTLPREKVRAAFEA 321
Cdd:cd03802   236 LLGGARALLFPINWDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETGFLVDSVEEMAEAIANIDRIDRAACRRYAED 315

                         330
                  ....*....|....*...
gi 1144540820 322 RFSSKVMAQNYVKGYEEL 339
Cdd:cd03802   316 RFSAARMADRYEALYRKV 333
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 2-337 1.26e-39

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 143.83  E-value: 1.26e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPlheaVPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQV 81
Cdd:cd03801     1 KILLLSP----ELPPPVGGAERHVRELARALAARGHDVTVLTPADPGEPPEELEDGVIVPLLPSLAALLRARRLLRELRP 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  82 RRRAEEFDVLHCH---IDYYPFSLFSRQPVPHLTTMHG------RLDLPELQPIFNAFSDVP-----VVSISDNQRiplp 147
Cdd:cd03801    77 LLRLRKFDVVHAHgllAALLAALLALLLGAPLVVTLHGaepgrlLLLLAAERRLLARAEALLrradaVIAVSEALR---- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 148 qaNWLSTVYhGLPENLLTPIPNV------------------KPSYLAFLGRISPEKRVDTAIRIAEQAgLPIKIAAKL-- 207
Cdd:cd03801   153 --DELRALG-GIPPEKIVVIPNGvdlerfspplrrklgippDRPVLLFVGRLSPRKGVDLLLEALAKL-LRRGPDVRLvi 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 208 ---DKADRAYYEEKIKPLfaLPHVEYIGEISESEKTEFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEV 284
Cdd:cd03801   229 vggDGPLRAELEELELGL--GDRVRFLGFVPDEELPALYAAADVFVLPSRY-EGFGLVVLEAMAAGLPVVATDVGGLPEV 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1144540820 285 IDNGVSGFVVEDELSA--VAALKRL---DTLPREKVRAA---FEARFSSKVMAQNYVKGYE 337
Cdd:cd03801   306 VEDGEGGLVVPPDDVEalADALLRLladPELRARLGRAArerVAERFSWERVAERLLDLYR 366
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 2-337 9.60e-31

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 119.74  E-value: 9.60e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPLHeavPPKLYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEA------CWPQALRLDPTIRDVMAPHM 75
Cdd:cd03823     1 KILLVNSLY---PPQRVGGAEISVHDLAEALVAEGHEVAVLTAGVGPPGQATVArsvvryRRAPDETLPLALKRRGYELF 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  76 L-----LLEQVRRRAEEF--DVLHCH----IDYYPFSLFSRQPVPHLTTMHgrlDLPELQP---IFNAFSDVpVVSIS-- 139
Cdd:cd03823    78 EtynpgLRRLLARLLEDFrpDVVHTHnlsgLGASLLDAARDLGIPVVHTLH---DYWLLCPrqfLFKKGGDA-VLAPSrf 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 140 --DNQRIPLPQANWLSTVYHGLPENL---LTPIPNVKPSYLAFLGRISPEKRVDTAIRIAEQA---GLPIKIAAKLDkad 211
Cdd:cd03823   154 taNLHEANGLFSARISVIPNAVEPDLappPRRRPGTERLRFGYIGRLTEEKGIDLLVEAFKRLpreDIELVIAGHGP--- 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 212 rayyEEKIKPLFALPHVEYIGEISESEKTEFLGNAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSG 291
Cdd:cd03823   231 ----LSDERQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIWPEPFGLVVREAIAAGLPVIASDLGGIAELIQPGVNG 306

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1144540820 292 FVVEDELSA--VAALKRLDTLPR--EKVRAAFEARFSSKVMAQNYVKGYE 337
Cdd:cd03823   307 LLFAPGDAEdlAAAMRRLLTDPAllERLRAGAEPPRSTESQAEEYLKLYR 356
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 19-326 2.75e-25

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 104.36  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLF---ASGDSQTSAKLEACWPQALRLDPTIRDVMAPhmLLLEQVRR--RAEEFDVLHC 93
Cdd:cd03811    12 GGAERVLLNLANALDKRGYDVTLVllrDEGDLDKQLNGDVKLIRLLIRVLKLIKLGLL--KAILKLKRilKRAKPDVVIS 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  94 HIDYYP--FSLFSRQPVPHLTTMHGrlDLPELQPIFNAFSDVP--------VVSISDnqriplPQANWLSTVYHGLPENL 163
Cdd:cd03811    90 FLGFATyiVAKLAAARSKVIAWIHS--SLSKLYYLKKKLLLKLklykkadkIVCVSK------GIKEDLIRLGPSPPEKI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 164 LT-----PIPNVKPS-------------YLAFLGRISPEKRVDTAIRIAEQAgLPIKIAAKL----DKADRAYYEEKIKP 221
Cdd:cd03811   162 EViynpiDIDRIRALakepilnepedgpVILAVGRLDPQKGHDLLIEAFAKL-RKKYPDVKLvilgDGPLREELEKLAKE 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 222 LFALPHVEYIGEISESEKteFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELS 299
Cdd:cd03811   241 LGLAERVIFLGFQSNPYP--YLKKADLFVLSSRY-EGFPNVLLEAMALGTPVVSTDCPGPREILDDGENGLLVPdgDAAA 317

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1144540820 300 AVAALKRLDTLP-----REKVRAAFEARFSSK 326
Cdd:cd03811   318 LAGILAALLQKKldaalRERLAKAQEAVFREY 349
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 171-310 3.25e-24

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 96.96  E-value: 3.25e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 171 KPSYLAFLGRISPEKRVDTAIRIAEQ---AGLPIKIAAKLDKADRAYYEEKIKPLFALPHVEYIGEISESEKTEFLGNAH 247
Cdd:pfam00534   1 KKKIILFVGRLEPEKGLDLLIKAFALlkeKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIAD 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1144540820 248 ALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDElSAVAALKRLDTL 310
Cdd:pfam00534  81 VFVLPSRY-EGFGIVLLEAMACGLPVIASDVGGPPEVVKDGETGFLVKPN-NAEALAEAIDKL 141
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 242-341 2.85e-21

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 87.74  E-value: 2.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 242 FLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAALKRLDTLP------RE 313
Cdd:COG0438    17 LLAAADVFVLPSRS-EGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETGLLVPpgDPEALAEAILRLLEDPelrrrlGE 95

                          90       100
                  ....*....|....*....|....*...
gi 1144540820 314 KVRAAFEARFSSKVMAQNYVKGYEELLR 341
Cdd:COG0438    96 AARERAEERFSWEAIAERLLALYEELLA 123
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 18-330 5.99e-21

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 92.43  E-value: 5.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  18 YGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQVRR--RAEEFDVLHCHI 95
Cdd:cd03809    13 LTGIGRYTRELLKALAKNDPDESVLAVPPLPGELLRLLREYPELSLGVIKIKLWRELALLRWLQILlpKKDKPDLLHSPH 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  96 DYYPFSLFSRQPV-----------PHLTTMHGRLDLPELQPIFNAFSDVpVVSISDNQR------IPLPqANWLSTVYHG 158
Cdd:cd03809    93 NTAPLLLKGCPQVvtihdliplryPEFFPKRFRLYYRLLLPISLRRADA-IITVSEATRddiikfYGVP-PEKIVVIPLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 159 LPENLLTPIPNV--------KPSYLAFLGRISPEKRVDTAIRIAEQA-----GLPIKIAAKLDKADRAYYEEkIKPLFAL 225
Cdd:cd03809   171 VDPSFFPPESAAvliakyllPEPYFLYVGTLEPRKNHERLLKAFALLkkqggDLKLVIVGGKGWEDEELLDL-VKKLGLG 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 226 PHVEYIGEISESEKTEFLGNAHALLFP-IDwpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAAL 304
Cdd:cd03809   250 GRVRFLGYVSDEDLPALYRGARAFVFPsLY--EGFGLPVLEAMACGTPVIASNISVLPEVAGDAALYFDPLDPESIADAI 327

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1144540820 305 KRL---DTLPREKVRAAFE--ARFSSKVMAQ 330
Cdd:cd03809   328 LRLledPSLREELIRKGLEraKKFSWEKTAE 358
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 175-339 6.45e-21

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 92.34  E-value: 6.45e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 175 LAFLGRISPEKRVDTAIRIaeQAGLPIKIAAKL----DKADRAYYEEKIKPLFALPHVEYIGEISESEKTEFLGNAHALL 250
Cdd:cd03817   204 LLYVGRLAKEKNIDFLLRA--FAELKKEPNIKLvivgDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFV 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 251 FPIDwPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE-DELSAVAALKRLDTLP--REKVRAAFEARFSSKV 327
Cdd:cd03817   282 FAST-TETQGLVYLEAMAAGLPVVAAKDPAASELVEDGENGFLFEpNDETLAEKLLHLRENLelLRKLSKNAEISAREFA 360

                         170
                  ....*....|..
gi 1144540820 328 MAQNYVKGYEEL 339
Cdd:cd03817   361 FAKSVEKLYEEV 372
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 19-322 9.67e-20

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 88.95  E-value: 9.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLFASGDsqTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQVRRRaEEFDVLHCHIDYY 98
Cdd:cd03819    11 GGAETYILDLARALAERGHRVLVVTAGG--PLLPRLRQIGIGLPGLKVPLLRALLGNVRLARLIRR-ERIDLIHAHSRAP 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  99 PFS--LFSRQP-VPHLTTMHGR------LDLPELQPIFNAFSDVPVV-SISDN--QRIPLPQANwLSTVYHGLPENLLTP 166
Cdd:cd03819    88 AWLgwLASRLTgVPLVTTVHGSylatyhPKDFALAVRARGDRVIAVSeLVRDHliEALGVDPER-IRVIPNGVDTDRFPP 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 167 -----------IPNVKPSyLAFLGRISPEKRVDTAIRIAE--QAGLPIKIAAKLDKADRAYYEEKIKPLFALPHVEYIGE 233
Cdd:cd03819   167 eaeaeeraqlgLPEGKPV-VGYVGRLSPEKGWLLLVDAAAelKDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 234 ISESekTEFLGNAHALLFPiDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAALKRLDTLP 311
Cdd:cd03819   246 REDV--PAALAASDVVVLP-SLHEEFGRVALEAMACGTPVVATDVGGAREIVVHGRTGLLVPpgDAEALADAIRAAKLLP 322

                         330
                  ....*....|....
gi 1144540820 312 --REK-VRAAFEAR 322
Cdd:cd03819   323 eaREKlQAAAALTE 336
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 13-294 1.29e-19

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 86.69  E-value: 1.29e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  13 VPPKLYGGTERVVSYLTEALVEMGHDVTLFAsgdsqtsakleacwpqalrldptirdvMAPHMLLLEQVRRRAEEFDVLH 92
Cdd:cd01635     7 EYPPLRGGLELHVRALARALAALGHEVTVLA---------------------------LLLLALRRILKKLLELKPDVVH 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  93 CHiDYYPFSLFS-----RQPVPHLTTMHGRLDLPELQPIFNAFSdvpvvsisdNQRIPLPQANWLstvyhglpenlltpi 167
Cdd:cd01635    60 AH-SPHAAALAAllaarLLGIPIVVTVHGPDSLESTRSELLALA---------RLLVSLPLADKV--------------- 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 168 pnvkpsylaFLGRISPEKRVDTAIRIAEQAGLPIKIAAKL---DKADRAYYEEKIKPLFALPHVEYIGEISESEKTEFLG 244
Cdd:cd01635   115 ---------SVGRLVPEKGIDLLLEALALLKARLPDLVLVlvgGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLL 185

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1144540820 245 N-AHALLFPiDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVV 294
Cdd:cd01635   186 AaADVFVLP-SRSEGFGLVLLEAMAAGKPVIATDVGGIPEFVVDGENGLLV 235
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 19-330 1.89e-19

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 88.06  E-value: 1.89e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEacwpqalrLDPTIR------DVMAPHMLLLEQVRR--------R 84
Cdd:cd03820    13 GGAERVAINLANHLAKKGYDVTIISLDSAEKPPFYE--------LDDNIKiknlgdRKYSHFKLLLKYFKKvrrlrkylK 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  85 AEEFDVLhchIDYYPFSLFS----RQPVPHLTTMHGRLD--LPELQPIFN------AFSDVPVVSISDNQRIPLPQANWL 152
Cdd:cd03820    85 NNKPDVV---ISFRTSLLTFlaliGLKSKLIVWEHNNYEayNKGLRRLLLrrllykRADKIVVLTEADKLKKYKQPNSNV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 153 STVYHGLPENLLTPIPNVKPSYLAFLGRISPEKRVDTAIRIA-----EQAGLPIKIAAklDKADRAYYEEKIKPLFALPH 227
Cdd:cd03820   162 VVIPNPLSFPSEEPSTNLKSKRILAVGRLTYQKGFDLLIEAWaliakKHPDWKLRIYG--DGPEREELEKLIDKLGLEDR 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 228 VEYIGEISESEktEFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVP-EVIDNGVSGFVVEDELSA--VAAL 304
Cdd:cd03820   240 VKLLGPTKNIA--EEYANSSIFVLSSRY-EGFPMVLLEAMAYGLPIISFDCPTGPsEIIEDGENGLLVPNGDVDalAEAL 316

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1144540820 305 KRL---DTLpREKV-RAAFE--ARFS-SKVMAQ 330
Cdd:cd03820   317 LRLmedEEL-RKKMgKNARKnaERFSiEKIIKQ 348
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 31-339 2.73e-19

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 87.82  E-value: 2.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  31 ALVEMGHDVTLFASGDSQTsaKLEACWPQALRLDPTIRDVMAPHML-----------------LLEQVRRRaeEFDVLHC 93
Cdd:cd03798    26 ALSRRGVDVEVLAPAPWGP--AAARLLRKLLGEAVPPRDGRRLLPLkprlrllaplrapslakLLKRRRRG--PPDLIHA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  94 HIDY---YPFSLFSR-QPVPHLTTMHGRlDLpelqpifNAFSDVPVVSiSDNQRIpLPQANWLSTVYHGL---------P 160
Cdd:cd03798   102 HFAYpagFAAALLARlYGVPYVVTEHGS-DI-------NVFPPRSLLR-KLLRWA-LRRAARVIAVSKALaeelvalgvP 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 161 ENLLTPIPNV-----------------KPSYLAFLGRISPEKRVDTAIRIAE---QAGLPIKIAAKLDKADRAYYEEKIK 220
Cdd:cd03798   172 RDRVDVIPNGvdparfqpedrglglplDAFVILFVGRLIPRKGIDLLLEAFArlaKARPDVVLLIVGDGPLREALRALAE 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 221 PLFALPHVEYIGEISESEKTEFLGNAHALLFPiDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DEL 298
Cdd:cd03798   252 DLGLGDRVTFTGRLPHEQVPAYYRACDVFVLP-SRHEGFGLVLLEAMACGLPVVATDVGGIPEVVGDPETGLLVPpgDAD 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1144540820 299 SAVAALKRL--DTLPREKVRAAFE---ARFSSKVMAQNYVKGYEEL 339
Cdd:cd03798   331 ALAAALRRAlaEPYLRELGEAARArvaERFSWVKAADRIAAAYRDV 376
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 175-322 3.81e-19

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 87.35  E-value: 3.81e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 175 LAFLGRISPEKRVDTAIRIAE--QAGLPIKIAAKLDKADRAYYEEkikplfALPHVEYIGEISESEKTEFLGNAHALLFP 252
Cdd:cd03814   201 LLYVGRLAPEKNLEALLDADLplAASPPVRLVVVGDGPARAELEA------RGPDVIFTGFLTGEELARAYASADVFVFP 274

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1144540820 253 IDwPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAALKRLDTLPREKVRAAFEAR 322
Cdd:cd03814   275 SR-TETFGLVVLEAMASGLPVVAADAGGPRDIVRPGGTGALVEpgDAAAFAAALRALLEDPELRRRMAARAR 345
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 18-329 2.36e-18

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 85.02  E-value: 2.36e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  18 YGGTERVVSYLTEALVEMGHDVT-LFASGDSQTSAKLEA-CWPQALRLDPTIRDVM-APHMLLleQVRRRAEEFDVLHCH 94
Cdd:cd03795    13 IGGIEQVIYDLAEGLKKKGIEVDvLCFSKEKETPEKEENgIRIHRVKSFLNVASTPfSPSYIK--RFKKLAKEYDIIHYH 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  95 idyYPF------SLFSRQPVPHLTTMHgrLD-------LPELQPIFNAF---SDVPVVSiSDNQR--------------- 143
Cdd:cd03795    91 ---FPNpladllLFFSGAKKPVVVHWH--SDivkqkklLKLYKPLMTRFlrrADRIIAT-SPNYVetsptlrefknkvrv 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 144 IPL----PQANWLSTVYHGLPENlltpipNVKPSYLAFLGRISPEKRVDTAIRIAEQAGLPIKIAAklDKADRAYYEEKI 219
Cdd:cd03795   165 IPLgidkNVYNIPRVDFENIKRE------KKGKKIFLFIGRLVYYKGLDYLIEAAQYLNYPIVIGG--EGPLKPDLEAQI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 220 KpLFALPHVEYIGEISESEKTEFLGNAHALLFPIDW-PEPFGLVMIEAMACGTPVIAFKRG-SVPEVIDNGVSGFVVE-- 295
Cdd:cd03795   237 E-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVLrSEAFGIVLLEAMMCGKPVISTNIGtGVPYVNNNGETGLVVPpk 315

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1144540820 296 --DELS-AVAALKRLDTLPREKVRAA---FEARFSSKVMA 329
Cdd:cd03795   316 dpDALAeAIDKLLSDEELRESYGENAkkrFEELFTAEKMK 355
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 28-332 1.00e-17

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 83.03  E-value: 1.00e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  28 LTEALVEMGHDVTLFASGDSQTSAKLEAcwpQALRLDPTIRDVMAPH----MLLLEQVRR--RAEEFDVLHCHidyypFS 101
Cdd:cd03808    19 LIKALVKKGYEVHVIAPDGDKLSDELKE---LGVKVIDIPILRRGINplkdLKALFKLYKllKKEKPDIVHCH-----TP 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 102 -------LFSRQ----PVPHLTTMHGRLDL--PELQPIFN-------AFSDVpVVSISDNQRIPLPQAN----WLSTVYH 157
Cdd:cd03808    91 kpgilgrLAARLagvpKVIYTVHGLGFVFTegKLLRLLYLlleklalLFTDK-VIFVNEDDRDLAIKKGiikkKKTVLIP 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 158 GLPENLlTPIPNVKPSY------LAFLGRISPEKRVDT---AIRIAEQAGLPIK--IAAKLDkaDRAYYEEKIKPLFALP 226
Cdd:cd03808   170 GSGVDL-DRFQYSPESLpsekvvFLFVARLLKDKGIDElieAAKILKKKGPNVRflLVGDGE--LENPSEILIEKLGLEG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 227 HVEYIGEISESEktEFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAAL 304
Cdd:cd03808   247 RIEFLGFRSDVP--ELLAESDVFVLPSYR-EGLPRSLLEAMAAGRPVITTDVPGCRELVIDGVNGFLVPpgDVEALADAI 323

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1144540820 305 KRLDTLP--REKV----RAAFEARFSSKVMAQNY 332
Cdd:cd03808   324 EKLIEDPelRKEMgeaaRKRVEEKFDEEKVVNKL 357
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 2-333 1.66e-17

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 82.80  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820   2 RIAQIAPLheaVPPKlYGGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEAcwpqALRLDPTIRDVMAPHML----- 76
Cdd:cd03821     1 KILHVTPS---ISPK-AGGPVKVVLRLAAALAALGHEVTIVSTGDGYESLVVEE----NGRYIPPQDGFASIPLLrqgag 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  77 -------LLEQVRRRAEEFDVLHCHIDYYPFSLF-----SRQPVPHLTTMHGRLD----------------LPELQPIFN 128
Cdd:cd03821    73 rtdfspgLPNWLRRNLREYDVVHIHGVWTYTSLAacklaRRRGIPYVVSPHGMLDpwalqqkhwkkrialhLIERRNLNN 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 129 AFSD-VPVVSISDNQRIPLPQANwLSTVYHGL------PENLLTPIPNVKPS--YLAFLGRISPEKRVDTAIRIAEqagl 199
Cdd:cd03821   153 AALVhFTSEQEADELRRFGLEPP-IAVIPNGVdipefdPGLRDRRKHNGLEDrrIILFLGRIHPKKGLDLLIRAAR---- 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 200 piKIAAKLDKA-------DRAYYEEKIKPLFAL---PHVEYIGEISESEKTEFLGNAHALLFPiDWPEPFGLVMIEAMAC 269
Cdd:cd03821   228 --KLAEQGRDWhlviagpDDGAYPAFLQLQSSLglgDRVTFTGPLYGEAKWALYASADLFVLP-SYSENFGNVVAEALAC 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1144540820 270 GTPVIAFKRGSVPEVIDNGvSGFVVEDELSAVA-ALKRL--DTLPREKVRA------AFEARFSSKVMAQNYV 333
Cdd:cd03821   305 GLPVVITDKCGLSELVEAG-CGVVVDPNVSSLAeALAEAlrDPADRKRLGEmarrarQVEENFSWEAVAGQLG 376
GT4_WbaZ-like cd03804
mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 ...
 174-332 1.89e-17

mannosyltransferase WbaZ and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbaZ in Salmonella enterica has been shown to possess mannosyltransferase activity.


Pssm-ID: 340833 [Multi-domain]  Cd Length: 356  Bit Score: 82.33  E-value: 1.89e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 174 YLAfLGRISPEKRVDTAIRIAEQAGLPIKIAAklDKADRAYYEEKikplfALPHVEYIGEISESEKTEFLGNAHALLFPI 253
Cdd:cd03804   202 YLT-ASRLVPYKRIDLAVEAFNELPKRLVVIG--DGPDLDRLRAM-----ASPNVEFLGYQPDEVLKELLSKARAFVFAA 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 254 DwpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFV-----VEDELSAVAALKRL-DTLPREKVRAAFEaRFSSKV 327
Cdd:cd03804   274 E--EDFGIVPVEAQACGTPVIAFGKGGALETVRPGPTGILfgeqtVESLKAAVEEFEQNfDRFKPQAIRANAE-RFSRAR 350


                  ....*
gi 1144540820 328 MAQNY 332
Cdd:cd03804   351 FRQEI 355
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 257-339 3.69e-17

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 81.61  E-value: 3.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 257 EPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVV--EDELSAVAALKRLDTLP------REKVRAAFEARFSSKVM 328
Cdd:cd03825   274 DNLPNTLLEAMACGTPVVAFDTGGSPEIVQHGVTGYLVppGDVQALAEAIEWLLANPkereslGERARALAENHFDQRVQ 353

                          90
                  ....*....|.
gi 1144540820 329 AQNYVKGYEEL 339
Cdd:cd03825   354 AQRYLELYKDL 364
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
174-307 4.25e-17

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 76.78  E-value: 4.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 174 YLAFLGRISPE-KRVDTAIRIAEQAgLPIKIAAKLD---KADRAYYEEKIKPLfaLPHVEYIGEISEseKTEFLGNAHAL 249
Cdd:pfam13692   3 VILFVGRLHPNvKGVDYLLEAVPLL-RKRDNDVRLVivgDGPEEELEELAAGL--EDRVIFTGFVED--LAELLAAADVF 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 250 LFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDnGVSGFVVE--DELSAVAALKRL 307
Cdd:pfam13692  78 VLPSLY-EGFGLKLLEAMAAGLPVVATDVGGIPELVD-GENGLLVPpgDPEALAEAILRL 135
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 18-339 3.18e-16

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 78.93  E-value: 3.18e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  18 YGGTERVVSYLTEALVEMGHDVTLFAS-------GDSQTSAKLEACWPQ-ALRLDPtirdvmaPHMLLL-----EQVRRr 84
Cdd:cd04962    11 YGGSGVVATELGLELAERGHEVHFISSaipfrlnLYSGNIFFHEVEVPNyPLFEYP-------PYTLALaskivEVAKE- 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  85 aEEFDVLHCH--IDYYPFSLFSRQ----PVPHLTTMHGRlDL------PELQPIfNAF----SDVpVVSISDNQRIplpq 148
Cdd:cd04962    83 -HKLDVLHAHyaIPHASCAYLAREilgeKIPIVTTLHGT-DItlvgydPSLQPA-VRFsinkSDR-VTAVSSSLRQ---- 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 149 anwlSTVYHGLPENLLTPIPN--------------VKPSYLA-----FLGRIS---PEKRVDTAIRIAEQagLPIKIAAK 206
Cdd:cd04962   155 ----ETYELFDVDKDIEVIHNfidedvfkrkpagaLKRRLLAppdekVVIHVSnfrPVKRIDDVVRVFAR--VRRKIPAK 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 207 L----DKADRAYYEEKIKPLFALPHVEYIGEISESEktEFLGNAHALLFPiDWPEPFGLVMIEAMACGTPVIAFKRGSVP 282
Cdd:cd04962   229 LllvgDGPERVPAEELARELGVEDRVLFLGKQDDVE--ELLSIADLFLLP-SEKESFGLAALEAMACGVPVVSSNAGGIP 305

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1144540820 283 EVIDNGVSGFVVE-DELSAVA--ALKRL--DTLPREKVRAAFE---ARFSSKVMAQNYVKGYEEL 339
Cdd:cd04962   306 EVVKHGETGFLSDvGDVDAMAksALSILedDELYNRMGRAARKraaERFDPERIVPQYEAYYRRL 370
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 19-341 1.75e-12

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 67.73  E-value: 1.75e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLFA-SGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQVRRRAeeFDVLHCHIdY 97
Cdd:cd03807    12 GGAETMLLRLLEHMDKSRFEHVVISlTGDGVLGEELLAAGVPVVCLGLSSGKDPGVLLRLAKLIRKRN--PDVVHTWM-Y 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  98 YPfSLFSRQP------VPHLTTMHGRLDLPELQPIFNA----FSDVPVVSISDNQRIPLPQANWlstvyhGLPENLLTPI 167
Cdd:cd03807    89 HA-DLIGGLAaklaggVKVIWSVRSSNIPQRLTRLVRKlcllLSKFSPATVANSSAVAEFHQEQ------GYAKNKIVVI 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 168 PN-VKPSYLAF-----------------------LGRISPEKRVDTAIRIAEQ---AGLPIKIAAKLDKADRAYYEEKIK 220
Cdd:cd03807   162 YNgIDLFKLSPddasrararrrlglaedrrvigiVGRLHPVKDHSDLLRAAALlveTHPDLRLLLVGRGPERPNLERLLL 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 221 PLFALPHVEYIGEISESekTEFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGvSGFVV--EDEL 298
Cdd:cd03807   242 ELGLEDRVHLLGERSDV--PALLPAMDIFVLSSRT-EGFPNALLEAMACGLPVVATDVGGAAELVDDG-TGFLVpaGDPQ 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1144540820 299 SAVAALKRLDTLPREKVRAAFEARfsSKVMA----QNYVKGYEELLR 341
Cdd:cd03807   318 ALADAIRALLEDPEKRARLGRAAR--ERIANefsiDAMVRRYETLYY 362
GT4_ALG2-like cd03805
alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely ...
 227-331 3.16e-11

alpha-1,3/1,6-mannosyltransferase ALG2 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG2, a 1,3-mannosyltransferase, in yeast catalyzes the mannosylation of Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. A deficiency of this enzyme causes an abnormal accumulation of Man1GlcNAc2-PP-dolichol and Man2GlcNAc2-PP-dolichol, which is associated with a type of congenital disorders of glycosylation (CDG), designated CDG-Ii, in humans.


Pssm-ID: 340834 [Multi-domain]  Cd Length: 392  Bit Score: 64.15  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 227 HVEYIGEISESEKTEFLGNAHALLF-PIDwpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE----DELSAV 301
Cdd:cd03805   281 QVLFLRSISDSQKEQLLSSALALLYtPSN--EHFGIVPLEAMYAGKPVIACNSGGPLETVVEGVTGFLCEptpeAFAEAM 358

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1144540820 302 AALKRLDTLPR---EKVRAAFEARFSSKVMAQN 331
Cdd:cd03805   359 LKLANDPDLADrmgAAGRKRVKEKFSREAFAER 391
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 175-312 8.06e-11

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 62.64  E-value: 8.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 175 LAFLGRISPEKRVDTAIR-------IAEQAGLPI---KIAAKLDKADRAYyEEKIKPLFALPHVEYIGEISESEKTEFLG 244
Cdd:cd03800   223 VLALGRLDPRKGIDTLVRafaqlpeLRELANLVLvggPSDDPLSMDREEL-AELAEELGLIDRVRFPGRVSRDDLPELYR 301

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 245 NAHALLFPiDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE--DELSAVAALKRLDTLPR 312
Cdd:cd03800   302 AADVFVVP-SLYEPFGLTAIEAMACGTPVVATAVGGLQDIVRDGRTGLLVDphDPEALAAALRRLLDDPA 370
Glyco_transf_4 pfam13439
Glycosyltransferase Family 4;
19-120 3.75e-10

Glycosyltransferase Family 4;


Pssm-ID: 463877 [Multi-domain]  Cd Length: 169  Bit Score: 58.31  E-value: 3.75e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEACWPQALRLDPTIRDVMAPHMLLLEQVRR--RAEEFDVLHCHiD 96
Cdd:pfam13439   1 GGVERYVLELARALARRGHEVTVVTPGGPGPLAEEVVRVVRVPRVPLPLPPRLLRSLAFLRRLRRllRRERPDVVHAH-S 79

                          90       100
                  ....*....|....*....|....*....
gi 1144540820  97 YYPFSLF-----SRQPVPHLTTMHGRLDL 120
Cdd:pfam13439  80 PFPLGLAalaarLRLGIPLVVTYHGLFPD 108
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 89-318 2.25e-09

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 58.23  E-value: 2.25e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  89 DVLHCHIDY---YPFSLFSRQPVPHLTTMHGrLDLPELQPIFNAFSDVPVVSISDNQRIPLPQANWLSTVYH-------- 157
Cdd:cd05844    83 ALVHAHFGRdgvYALPLARALGVPLVVTFHG-FDITTSRAWLAASPGWPSQFQRHRRALQRPAALFVAVSGFirdrllar 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 158 GLPENLLTPIP-NVKPSYLAFLGRISPEKRVDTAIRIAEQAGLPIKIAAKLDKADR----AYYEEKIKPLF--------A 224
Cdd:cd05844   162 GLPAERIHVHYiGIDPAKFAPRDPAERAPTILFVGRLVEKKGCDVLIEAFRRLAARhptaRLVIAGDGPLRpalqalaaA 241

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 225 LPHVEYIGEISESEKTEFLGNAHALLFPIDWP-----EPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVV-EDEL 298
Cdd:cd05844   242 LGRVRFLGALPHAEVQDWMRRAEIFCLPSVTAasgdsEGLGIVLLEAAACGVPVVSSRHGGIPEAILDGETGFLVpEGDV 321

                         250       260
                  ....*....|....*....|
gi 1144540820 299 SAVAAlkRLDTLPREKVRAA 318
Cdd:cd05844   322 DALAD--ALQALLADRALAD 339
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 150-333 9.76e-08

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 53.11  E-value: 9.76e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 150 NW--LSTVYHGLPENLLTPIPNVKPSYLAFLGRISPEKRVDTAIRIAEQagLPIKIAAKL----DKADRAYYEEKIKPLf 223
Cdd:cd03794   193 NWadLEEFKPPPKDELRKKLGLDDKFVVVYAGNIGKAQGLETLLEAAER--LKRRPDIRFlfvgDGDEKERLKELAKAR- 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 224 ALPHVEYIGEISESEKTEFLGNAHALLFPI-DWPEPFGLVMI---EAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELS 299
Cdd:cd03794   270 GLDNVTFLGRVPKEEVPELLSAADVGLVPLkDNPANRGSSPSklfEYMAAGKPILASDDGGSDLAVEINGCGLVVEPGDP 349

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1144540820 300 A--VAALKRL--DTLPREKV----RAAFEARFSSKVMAQNYV 333
Cdd:cd03794   350 EalADAILELldDPELRRAMgengRELAEEKFSREKLADRLL 391
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 169-303 1.35e-07

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 52.84  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 169 NVKPSYLAFLGRIspekRVDTAIRIAEQAGLPIKIAA--KL-------------DKADRAYYEEKIKPLFALPHVEYIGE 233
Cdd:cd03799   163 RFKPRYLPLDGKI----RILTVGRLTEKKGLEYAIEAvaKLaqkypnieyqiigDGDLKEQLQQLIQELNIGDCVKLLGW 238

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1144540820 234 ISESEKTEFLGNAHALLFPI------DWPEPFGLVMiEAMACGTPVIAFKRGSVPEVIDNGVSGFVV-EDELSAVAA 303
Cdd:cd03799   239 KPQEEIIEILDEADIFIAPSvtaadgDQDGPPNTLK-EAMAMGLPVISTEHGGIPELVEDGVSGFLVpERDAEAIAE 314
stp2 TIGR03088
sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match ...
 257-340 2.14e-07

sugar transferase, PEP-CTERM/EpsH1 system associated; Members of this family include a match to the pfam00534 Glycosyl transferases group 1 domain. Nearly all are found in species that encode the PEP-CTERM/exosortase system predicted to act in protein sorting in a number of Gram-negative bacteria. In particular, these transferases are found proximal to a particular variant of exosortase, EpsH1, which appears to travel with a conserved group of genes summarized by Genome Property GenProp0652. The nature of the sugar transferase reaction catalyzed by members of this clade is unknown and may conceivably be variable with respect to substrate by species, but we hypothesize a conserved substrate.


Pssm-ID: 132132 [Multi-domain]  Cd Length: 374  Bit Score: 52.03  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 257 EPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVV--EDELSAVAALKRLDTLPREKV------RAAFEARFSSKVM 328
Cdd:TIGR03088 283 EGISNTILEAMASGLPVIATAVGGNPELVQHGVTGALVppGDAVALARALQPYVSDPAARRahgaagRARAEQQFSINAM 362

                          90
                  ....*....|..
gi 1144540820 329 AQNYVKGYEELL 340
Cdd:TIGR03088 363 VAAYAGLYDQLL 374
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
175-300 2.21e-07

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 52.10  E-value: 2.21e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 175 LAFLGRISPEKRVDTAIRIAEQ---AGLPIKIAAKLD-----KADRAYYEEKIKPLFAL--PHVEYIGEISESEKTEFLG 244
Cdd:PRK15484  196 LLYAGRISPDKGILLLMQAFEKlatAHSNLKLVVVGDptassKGEKAAYQKKVLEAAKRigDRCIMLGGQPPEKMHNYYP 275

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1144540820 245 NAHALLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSA 300
Cdd:PRK15484  276 LADLVVVPSQVEEAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITGYHLAEPMTS 331
GT5_Glycogen_synthase_DULL1-like cd03791
Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 ...
 158-338 4.50e-07

Glycogen synthase GlgA and similar proteins; This family is most closely related to the GT5 family of glycosyltransferases. Glycogen synthase (EC:2.4.1.21) catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family includes starch synthases of plants, such as DULL1 in Zea mays and glycogen synthases of various organisms.


Pssm-ID: 340822 [Multi-domain]  Cd Length: 474  Bit Score: 51.41  E-value: 4.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 158 GLPENLLTPIpnvkpsyLAFLGRISPEKRVDTAIRIAEQA-GLPIKIA------AKLDKADRAY---YEEK----IKPLF 223
Cdd:cd03791   287 GLPVDPDAPL-------FGFVGRLTEQKGVDLILDALPELlEEGGQLVvlgsgdPEYEQAFRELaerYPGKvavvIGFDE 359

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 224 ALPHVEYIGeisesekteflgnAHALLFP-IDwpEPFGLVMIEAMACGTPVIAFKRG----SVPEV--IDNGVSGFVVE- 295
Cdd:cd03791   360 ALAHRIYAG-------------ADFFLMPsRF--EPCGLVQMYAMRYGTLPIVRRTGgladTVFDYdpETGEGTGFVFEd 424

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1144540820 296 -DELSAVAALKRLDTLPREK------VRAAFEARFSSKVMAQNYVKGYEE 338
Cdd:cd03791   425 yDAEALLAALRRALALYRNPelwrklQKNAMKQDFSWDKSAKEYLELYRS 474
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 154-307 1.17e-06

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 50.03  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 154 TVYHGLPENLLTPI----PNVKPSYLAFLGRISPEKRVDTAIRiaeqaglPIKIAAKLDK-----------ADRAYYEE- 217
Cdd:cd03813   271 VIPNGIDIQRFAPAreerPEKEPPVVGLVGRVVPIKDVKTFIR-------AFKLVRRAMPdaegwligpedEDPEYAQEc 343

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 218 --KIKPLFALPHVEYIGEISESEKTEFLGnahaLLFPIDWPEPFGLVMIEAMACGTPVIAFKRGSVPEVI-----DNGVS 290
Cdd:cd03813   344 krLVASLGLENKVKFLGFQNIKEYYPKLG----LLVLTSISEGQPLVILEAMASGVPVVATDVGSCRELIygaddALGQA 419

                         170
                  ....*....|....*....
gi 1144540820 291 GFVV--EDELSAVAALKRL 307
Cdd:cd03813   420 GLVVppADPEALAEALIKL 438
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 154-330 2.33e-06

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 48.84  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 154 TVYHGLPENLLTPIPNV--KPSYLAFLGRISPEKRVDTAIRIAEQA--GLPikiAAKLDKADRAYYEEKIKPLFALPHVE 229
Cdd:cd04949   140 TIPVGYVDQLDTAESNHerKSNKIITISRLAPEKQLDHLIEAVAKAvkKVP---EITLDIYGYGEEREKLKKLIEELHLE 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 230 -------YIGEISESEKteflgNAHALLFPIDWpEPFGLVMIEAMACGTPVIAF--KRGSvPEVIDNGVSGFVVE--DEL 298
Cdd:cd04949   217 dnvflkgYHSNLDQEYQ-----DAYLSLLTSQM-EGFGLTLMEAIGHGLPVVSYdvKYGP-SELIEDGENGYLIEknNID 289

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1144540820 299 SAVAALKRL---DTLPREKVRAAFE--ARFSSK-VMAQ 330
Cdd:cd04949   290 ALADKIIELlndPEKLQQFSEESYKiaEKYSTEnVMEK 327
Glyco_trans_4_4 pfam13579
Glycosyl transferase 4-like domain;
19-118 2.45e-06

Glycosyl transferase 4-like domain;


Pssm-ID: 433325 [Multi-domain]  Cd Length: 158  Bit Score: 47.01  E-value: 2.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  19 GGTERVVSYLTEALVEMGHDVTLFASGDSQTSAKLEA--CWPQALRLDPTIRDVMAPHMLLleQVRR--RAEEFDVLHCH 94
Cdd:pfam13579   1 GGIGVYVLELARALAALGHEVRVVTPGGPPGRPELVGdgVRVHRLPVPPRPSPLADLAALR--RLRRllRAERPDVVHAH 78

                          90       100
                  ....*....|....*....|....*....
gi 1144540820  95 idYYPFSLF-----SRQPVPHLTTMHGRL 118
Cdd:pfam13579  79 --SPTAGLAarlarRRRGVPLVVTVHGLA 105
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 208-294 2.91e-06

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 48.60  E-value: 2.91e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 208 DKADRAYYEEKIKPLFALPHVEYIGEISESEktEFLGNAHALLFPIDWpEPFGLVMIEAMACGTPVIAFKRGSVPEVIDN 287
Cdd:cd04951   227 DGPLRNELERLICNLNLVDRVILLGQISNIS--EYYNAADLFVLSSEW-EGFGLVVAEAMACERPVVATDAGGVAEVVGD 303


                  ....*..
gi 1144540820 288 gvSGFVV 294
Cdd:cd04951   304 --HNYVV 308
PLN00142 PLN00142
sucrose synthase
 257-292 5.05e-06

sucrose synthase


Pssm-ID: 215073 [Multi-domain]  Cd Length: 815  Bit Score: 48.44  E-value: 5.05e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1144540820 257 EPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGF 292
Cdd:PLN00142  677 EAFGLTVVEAMTCGLPTFATCQGGPAEIIVDGVSGF 712
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 179-322 5.73e-06

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 47.78  E-value: 5.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 179 GRISPEKRVDTAIRIAEQagLPikiAAKLDKADRAYYEEKIKPLFALPHVEYIGEISESEKTEFLGNAHALLFPIDwPEP 258
Cdd:PLN02871  270 GRLGAEKNLDFLKRVMER--LP---GARLAFVGDGPYREELEKMFAGTPTVFTGMLQGDELSQAYASGDVFVMPSE-SET 343

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1144540820 259 FGLVMIEAMACGTPVIAFKRGSVPEVIDN---GVSGFVVE--DELSAVAALKRLDTLPREKVRAAFEAR 322
Cdd:PLN02871  344 LGFVVLEAMASGVPVVAARAGGIPDIIPPdqeGKTGFLYTpgDVDDCVEKLETLLADPELRERMGAAAR 412
GT4_ALG11-like cd03806
alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related ...
 168-331 3.34e-05

alpha-1,2-mannosyltransferase ALG11 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ALG11 in yeast is involved in adding the final 1,2-linked Man to the Man5GlcNAc2-PP-Dol synthesized on the cytosolic face of the ER. The deletion analysis of ALG11 was shown to block the early steps of core biosynthesis that takes place on the cytoplasmic face of the ER and lead to a defect in the assembly of lipid-linked oligosaccharides.


Pssm-ID: 340835 [Multi-domain]  Cd Length: 419  Bit Score: 45.29  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 168 PNVKPSYLAFLGRISPEKRVDTAIRI----AEQAGLPIKIAAKL-------DKADRAYYEE---KIKPLFALPHVEYIGE 233
Cdd:cd03806   233 EKTRENQILSIAQFRPEKNHPLQLRAfaelLKRLPESIRSNPKLvligscrNEEDKERVEAlklLAKELILEDSVEFVVD 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 234 ISESEKTEFLGNA----HALlfpidWPEPFGLVMIEAMACGTPVIAFKRGSVPEVI----DNGVSGFVVEDELSAVAALK 305
Cdd:cd03806   313 APYEELKELLSTAsiglHTM-----WNEHFGIGVVEYMAAGLIPLAHASAGPLLDIvvpwDGGPTGFLASTPEEYAEAIE 387

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1144540820 306 RLDTLP---REKVRAAFE---ARFSSKVMAQN 331
Cdd:cd03806   388 KILTLSeeeRLQRREAARssaERFSDEEFERD 419
GT4_ExpC-like cd03818
Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 ...
 263-332 1.74e-04

Rhizobium meliloti ExpC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II).


Pssm-ID: 340845 [Multi-domain]  Cd Length: 396  Bit Score: 43.12  E-value: 1.74e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1144540820 263 MIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVE-DELSAVAA-----LKRLDTLPREKV--RAAFEARFSSKVMAQNY 332
Cdd:cd03818   317 LLEAMACGCPVIGSDTAPVREVIRDGRNGLLVDfFDPDALAAavlelLEDPDRAAALRRaaRRTVERSDSLDVCLARY 394
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 256-334 3.93e-04

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 41.92  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 256 PEPFGLVMIEAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAALKRLDTLPR------EKVRAAFEARFSSKVMA 329
Cdd:cd03792   289 REGFGLTVSEALWKGKPVIATPAGGIPLQVIDGETGFLVNSVEGAAVRILRLLTDPElrrkmgLAAREHVRDNFLITGNL 368


                  ....*
gi 1144540820 330 QNYVK 334
Cdd:cd03792   369 RAWLY 373
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 228-334 6.16e-04

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 41.29  E-value: 6.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 228 VEYIGEISESEKTEFLGNAHALLFpIDWPEPFGL-VMI-EAMACGTPVIAFKRGSVPEVIDNGVSG------FVVEDELS 299
Cdd:cd04946   285 VNFTGEVSNKEVKQLYKENDVDVF-VNVSESEGIpVSImEAISFGIPVIATNVGGTREIVENETNGllldkdPTPNEIVS 363

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1144540820 300 AVAAL----KRLDTLpREKVRAAFEARFSSKVmaqNYVK 334
Cdd:cd04946   364 SIMKFyldgGDYKTM-KISARECWEERFNAEV---NYSK 398
sucrsPsyn_pln TIGR02468
sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this ...
 257-288 1.18e-03

sucrose phosphate synthase/possible sucrose phosphate phosphatase, plant; Members of this family are sucrose-phosphate synthases of plants. This enzyme is known to exist in multigene families in several species of both monocots and dicots. The N-terminal domain is the glucosyltransferase domain. Members of this family also have a variable linker region and a C-terminal domain that resembles sucrose phosphate phosphatase (SPP) (EC 3.1.3.24) (see TIGR01485), the next and final enzyme of sucrose biosynthesis. The SPP-like domain likely serves a binding and not a catalytic function, as the reported SPP is always encoded by a distinct protein.


Pssm-ID: 274147 [Multi-domain]  Cd Length: 1050  Bit Score: 40.92  E-value: 1.18e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1144540820  257 EPFGLVMIEAMACGTPVIAFKRGS---VPEVIDNG 288
Cdd:TIGR02468  582 EPFGLTLIEAAAHGLPMVATKNGGpvdIHRVLDNG 616
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 83-340 2.36e-03

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 39.58  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820  83 RRAEEFDVLHCHIDYYPFS--LFSRQ---PV----PHLTT-MHGRLD---LPELQPIFNAFSDVpVVSISDNQriplpqA 149
Cdd:cd03812    76 IKKEKYDIVHVHGSSSNGIilLLAAKagvPVriahSHNTKdSSIKLRkirKNVLKKLIERLSTK-YLACSEDA------G 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 150 NWL---------STVYHGLPENLLTPIPNVKPSYLAFL-----------GRISPEKrvdtairiaEQAGLpIKIAAKLDK 209
Cdd:cd03812   149 EWLfgevengkfKVIPNGIDIEKYKFNKEKRRKRRKLLiledklvlghvGRFNEQK---------NHSFL-IDIFEELKK 218

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 210 ADRAYY---------EEKIKplfalphvEYIGEISESEKTEFLGN----------AHALLFPIDWpEPFGLVMIEAMACG 270
Cdd:cd03812   219 KNPNVKlvlvgegelKEKIK--------EKVKELGLEDKVIFLGFrndvseilsaMDVFLFPSLY-EGLPLVAVEAQASG 289

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1144540820 271 TPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAalKRLDTLPREKVRAAFEARFSSKVMAQNYVKGYEELL 340
Cdd:cd03812   290 LPCLLSDTITKECDITNNVEFLPLNETPSTWA--EKILKLIKRKRRINKEINKEKKELGYDDESLELTLL 357
Glyco_trans_1_2 pfam13524
Glycosyl transferases group 1;
265-318 3.67e-03

Glycosyl transferases group 1;


Pssm-ID: 433281 [Multi-domain]  Cd Length: 93  Bit Score: 36.43  E-value: 3.67e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1144540820 265 EAMACGTPVIAFKRGSVPEVIDNGVSGFVVEDELSAVAALKRLDTLP--REKVRAA 318
Cdd:pfam13524  18 EAAACGAPLLTDRTPGLEELFEPGEEILLYRDPEELAEKIRYLLEHPeeRRAIAAA 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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