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penicillin-binding protein [Clostridium baratii]
Protein Classification
peptidoglycan D,D-transpeptidase FtsI family protein ( domain architecture ID 11433609 )
peptidoglycan D,D-transpeptidase FtsI (penicillin-binding protein (PBP) 2) family protein is a membrane-associated enzyme that is most likely involved in the synthesis of cross-linked peptidoglycan
List of domain hits
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-489
2.22e-111
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 341.03
E-value: 2.22e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 1 MK DDIK K SVTK ----- VMMVF L FCLIA L ITYIA Y F Q AFKAPDI A AKPGNQ R awa V R NRVL --- RG T IYDRN N NV I A KS V - 71
Cdd:COG0768 1 MK RKKE K RLFR rrlll LFLLV L LLFLL L VGRLF Y L Q VVEGDEY A ELAEEN R --- I R TVPI pap RG L IYDRN G NV L A TN V p 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 72 ------------------------------------ RE K NN ----------------------------- VQ KR V YP D G A 86
Cdd:COG0768 78 vyslyadpeevkdpeetaeklakllgldpeelrkkl KK K SR fpvylkrnlspeeaariralklpgvyvea EY KR Y YP Y G E 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 87 VF A API G FMDS ----- RF G G SGLE A AY DKQ L TT T snmt ASFKKLID D PS --- I AN L K E affdrk DDKDRQ G NSV V T T L DS 158
Cdd:COG0768 158 LA A HVL G YVGE inggd GI G K SGLE K AY EDL L RG T ---- PGKRRVEV D AR grv I RD L G E ------ EKPPVP G KDL V L T I DS 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 159 K LQK V A YN AL GN ------- DR GAVV AL DPKTG NV LAM V S K P TYN PN NLA eemkkansg DLEHSI L L NRA I QG Q Y P PGSTF 231
Cdd:COG0768 228 D LQK I A EE AL KK aveeyka KS GAVV VM DPKTG EI LAM A S Y P SFD PN LFV --------- GGPDEP L R NRA V QG T Y E PGSTF 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 232 K VV T T A S AL DN ip GV -- QNK TF TDN G VLKF eg GG KELHNSGDASY G S L D L KK A FVV SSNV VYGT LA MD LG N DKL MKTAER 309
Cdd:COG0768 299 K PF T A A A AL EE -- GV it PDT TF DCP G YYRV -- GG RTIRDWDRGGH G T L T L TE A LAK SSNV GFYK LA LR LG I DKL YDYLKK 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 310 FG FNEQ ---- I P -- A N G FTIGKSTF pklt Y S G DI A RSG IGQ S t II V N P M Q M A LVAS A V AN N GV IMQ P N LV SKV VD K DG TT 383
Cdd:COG0768 375 FG LGQK tgid L P ge A S G LLPSPKRW ---- Y P G ET A TMS IGQ G - LS V T P L Q L A QAYA A I AN G GV LVK P H LV KEI VD P DG EV 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 384 IE v E K P KEYQ R AM S EDD A A T IKSY M KAL V DKNIQSGTWSYL ------------ Q GTGTAGKTGTADHNL pngqpapph SW 451
Cdd:COG0768 450 VK - E E P EVLR R VI S PET A E T VREG M EGV V NEPGGTARRAAI pgyrvagktgta Q VVDIGNGGYYKGRHI --------- AS 519
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1143698743 452 F IC FAPADNP KI AVAVVVE DG G --- YG AKK AA S V AGKVIN A 489
Cdd:COG0768 520 F VG FAPADNP RY AVAVVVE NP G gga YG GTV AA P V FREIME A 560
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-489
2.22e-111
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 341.03
E-value: 2.22e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 1 MK DDIK K SVTK ----- VMMVF L FCLIA L ITYIA Y F Q AFKAPDI A AKPGNQ R awa V R NRVL --- RG T IYDRN N NV I A KS V - 71
Cdd:COG0768 1 MK RKKE K RLFR rrlll LFLLV L LLFLL L VGRLF Y L Q VVEGDEY A ELAEEN R --- I R TVPI pap RG L IYDRN G NV L A TN V p 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 72 ------------------------------------ RE K NN ----------------------------- VQ KR V YP D G A 86
Cdd:COG0768 78 vyslyadpeevkdpeetaeklakllgldpeelrkkl KK K SR fpvylkrnlspeeaariralklpgvyvea EY KR Y YP Y G E 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 87 VF A API G FMDS ----- RF G G SGLE A AY DKQ L TT T snmt ASFKKLID D PS --- I AN L K E affdrk DDKDRQ G NSV V T T L DS 158
Cdd:COG0768 158 LA A HVL G YVGE inggd GI G K SGLE K AY EDL L RG T ---- PGKRRVEV D AR grv I RD L G E ------ EKPPVP G KDL V L T I DS 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 159 K LQK V A YN AL GN ------- DR GAVV AL DPKTG NV LAM V S K P TYN PN NLA eemkkansg DLEHSI L L NRA I QG Q Y P PGSTF 231
Cdd:COG0768 228 D LQK I A EE AL KK aveeyka KS GAVV VM DPKTG EI LAM A S Y P SFD PN LFV --------- GGPDEP L R NRA V QG T Y E PGSTF 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 232 K VV T T A S AL DN ip GV -- QNK TF TDN G VLKF eg GG KELHNSGDASY G S L D L KK A FVV SSNV VYGT LA MD LG N DKL MKTAER 309
Cdd:COG0768 299 K PF T A A A AL EE -- GV it PDT TF DCP G YYRV -- GG RTIRDWDRGGH G T L T L TE A LAK SSNV GFYK LA LR LG I DKL YDYLKK 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 310 FG FNEQ ---- I P -- A N G FTIGKSTF pklt Y S G DI A RSG IGQ S t II V N P M Q M A LVAS A V AN N GV IMQ P N LV SKV VD K DG TT 383
Cdd:COG0768 375 FG LGQK tgid L P ge A S G LLPSPKRW ---- Y P G ET A TMS IGQ G - LS V T P L Q L A QAYA A I AN G GV LVK P H LV KEI VD P DG EV 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 384 IE v E K P KEYQ R AM S EDD A A T IKSY M KAL V DKNIQSGTWSYL ------------ Q GTGTAGKTGTADHNL pngqpapph SW 451
Cdd:COG0768 450 VK - E E P EVLR R VI S PET A E T VREG M EGV V NEPGGTARRAAI pgyrvagktgta Q VVDIGNGGYYKGRHI --------- AS 519
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1143698743 452 F IC FAPADNP KI AVAVVVE DG G --- YG AKK AA S V AGKVIN A 489
Cdd:COG0768 520 F VG FAPADNP RY AVAVVVE NP G gga YG GTV AA P V FREIME A 560
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
12-493
5.47e-93
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 294.05
E-value: 5.47e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 12 VMMVF LF CLI A LITY ia Y F Q AFKAPDI A AKPGNQ R awa V R NRVL --- RG T I Y DRN NNVI A -------------------- 68
Cdd:TIGR03423 8 GLVLA LF GVL A ARLF -- Y L Q VIRGEEY A TLSEDN R --- I R LVPI ppp RG L I L DRN GVLL A dnrpsfsleivpekvddlda 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 69 ----------------------------- KSVRE K NNV ----------------------- Q KR V YP D G AVF A API G FM - 95
Cdd:TIGR03423 83 tldrlaklldldpediarflkelkrsrrf EPIPL K SDL teeevarfavnqyrlpgveiear L KR Y YP Y G ELA A HVL G YV g 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 96 ----------------- DSRF G G SG L E AA Y DKQ L -------- TTTSNMTASFKK L IDD P SIA nlkeaffdrkddkdrq G N 150
Cdd:TIGR03423 163 eineedlerlepanyag GDYI G K SG I E KY Y EDE L rgkpgyre VEVNARGRVIRT L SRV P PVP ---------------- G K 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 151 SV V T T L D SK LQ KV A YN ALG ND RGAVV AL DP K TG NV LAMVS K P TYN PN NLAEEMKKANSGD L --- EHSI LLNRAIQG Q YPP 227
Cdd:TIGR03423 227 DL V L T I D AR LQ QA A EK ALG GR RGAVV VM DP R TG EI LAMVS T P SFD PN LFVDGISSKDYKA L lnd PDRP LLNRAIQG V YPP 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 228 GSTFK V V TTAS AL DN ip GV -- QNKTFTDN G VLKF eg GG KELHNSGDASY G SL DL K KA FVV S SN V VYGT LA MD LG N DK LMK 305
Cdd:TIGR03423 307 GSTFK P V VALA AL EE -- GV it PETRIYCP G YFQL -- GG RRFRCWKRGGH G RV DL R KA IEE S CD V YFYQ LA LR LG I DK IAE 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 306 T A E RFGF NEQ -- I PAN G FTI G -------- KST F PKLT Y S GD IARSG IGQ STII V N P M Q M A LVAS A V AN N G VIMQ P N LV SK 375
Cdd:TIGR03423 383 Y A K RFGF GQK tg I DLP G EKS G lvpsrewk RKR F GQPW Y P GD TLNVS IGQ GYVL V T P L Q L A VATA A L AN G G KLYK P H LV KS 462
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 376 VV D K DG TTIEVEK P KEYQRA - M S EDDAATIKSY M KAL V dk N IQS GT WSYL --------------- Q GTGTAGKTGTADHN 439
Cdd:TIGR03423 463 IE D P DG GVVRRTE P EVLRPL p I S PENLDVVREG M RDV V -- N GPG GT ARRA rlglpykmagktgta Q VVSLKQGEKYDAEQ 540
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1143698743 440 L P - NGQ pap P H SW F IC FAP A DNPKIAVAV V VE D GG Y G AKK AA SV A G K VIN A E L NK 493
Cdd:TIGR03423 541 I P e RLR --- D H AL F VA FAP Y DNPKIAVAV I VE H GG G G SSA AA PI A R K IMD A Y L LG 592
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
173-487
3.33e-48
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 167.98
E-value: 3.33e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 173 G AV V A LDPKTG N VLAMV S KP T Y N PN NLA eemkkansgdleh SI L L NRA IQGQ Y P PGSTFK VV T TAS ALDN ip GV -- QNK T 250
Cdd:pfam00905 1 G SA V V LDPKTG E VLAMV G KP S Y D PN GFI ------------- GP L R NRA VTSR Y E PGSTFK PF T ALA ALDN -- GV lk PDE T 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 251 FT D NGVLKFE G GGKELH N SGDASY G sl D L KK A FVV SSN VVYGT LA MD LG N DKL MKTAER FG FNEQIPAN -- G FTI G KS T F 328
Cdd:pfam00905 66 IF D WPGKQQG G KSIGDW N QDQVGI G -- T L RQ A LEY SSN WYMQK LA QK LG A DKL RSYLKK FG YGNKTGIG lp G ENA G YL T P 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 329 PK L ty S G DI A RS GIG qst IIVN P M Q M A LVAS A V AN N G VIMQ P N LV SKVV DK DGTTIEVEK P keyqra M S EDD A ATI K SYM 408
Cdd:pfam00905 144 YW L -- E G AT A SF GIG --- LTIT P L Q Q A QAYA A I AN G G KLVP P H LV KSIE DK VDPKVLNKL P ------ I S KST A EKV K DML 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 409 KAL V DKNIQS GT WSYL ----------- Q GT G TA G KTGTADHN lpngqpapp HS WF ICF APADNPK I A V AV VVE D GG -- YG 475
Cdd:pfam00905 213 RLV V NDGTGT GT AAVP gykvagktgta Q VA G PK G GGYYDGAQ --------- IG WF VGY APADNPK Y A F AV LID D PK ry YG 283
330
....*....|..
gi 1143698743 476 A K K AA SVAGKVI 487
Cdd:pfam00905 284 G K V AA PIFKDIL 295
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
149-475
1.92e-34
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 136.82
E-value: 1.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 149 G NSVVT TLD S KLQ KVAYNA L GND R G AVV AL DP K TG NV LA M VS K P T Y N PN NLAEEMKKANSGD L --- EHSI L L NRA I QG Q Y 225
Cdd:PRK10795 248 G HDIYL TLD L KLQ QYIETL L AGS R A AVV VT DP R TG GI LA L VS T P S Y D PN LFVDGISSKDYSG L lnd PNRP L I NRA T QG V Y 327
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 226 PP G ST F K VVTTA SAL D ni P GV QNKTFT -- D N G VLKFE G GG K ELHNSGDASY G S L DLK K AFVV S SNVVYGTL A M D L G N D K L 303
Cdd:PRK10795 328 PP A ST V K PYVAV SAL S -- A GV ITRNTS lf D P G WWQLP G SE K RYRDWKKWGH G R L NVT K SLEE S ADTFFYQV A Y D M G I D R L 405
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 304 MKTAER FG FNEQ ------------ I P ANGFTIGK st F P K LT Y S GD IARS GIGQ STIIVN P M QM ALVASAVA N N G VIMQ P N 371
Cdd:PRK10795 406 SEWMGK FG YGHY tgidlaeersgn M P TREWKQKR -- F K K PW Y Q GD TIPV GIGQ GYWTAT P I QM SKALMTLI N D G IVKV P H 483
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 372 L VSKVVD k DG TTIEVEK P K E YQRA mseddaatiksymkalvdk N I Q SG T W SYLQGTGTAGK tgtadh N L PNG QP ------ 445
Cdd:PRK10795 484 L LMSTAE - DG KQVPWVQ P H E PPVG ------------------- D I H SG Y W EIAKDGMYGVA ------ N R PNG TA hkyfas 537
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1143698743 446 AP ------------------------------- P H SWFIC FAP AD NP KI AVA VVV E D GG Y G 475
Cdd:PRK10795 538 AP ykiaaksgtaqvfglkanetynahkiaerlr D H KLMTA FAP YN NP QV AVA IIL E N GG A G 598
Name
Accession
Description
Interval
E-value
FtsI
COG0768 Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell ...
1-489
2.22e-111
Cell division protein FtsI, peptidoglycan transpeptidase (Penicillin-binding protein 2) [Cell cycle control, cell division, chromosome partitioning, Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440531 [Multi-domain]
Cd Length: 568
Bit Score: 341.03
E-value: 2.22e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 1 MK DDIK K SVTK ----- VMMVF L FCLIA L ITYIA Y F Q AFKAPDI A AKPGNQ R awa V R NRVL --- RG T IYDRN N NV I A KS V - 71
Cdd:COG0768 1 MK RKKE K RLFR rrlll LFLLV L LLFLL L VGRLF Y L Q VVEGDEY A ELAEEN R --- I R TVPI pap RG L IYDRN G NV L A TN V p 77
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 72 ------------------------------------ RE K NN ----------------------------- VQ KR V YP D G A 86
Cdd:COG0768 78 vyslyadpeevkdpeetaeklakllgldpeelrkkl KK K SR fpvylkrnlspeeaariralklpgvyvea EY KR Y YP Y G E 157
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 87 VF A API G FMDS ----- RF G G SGLE A AY DKQ L TT T snmt ASFKKLID D PS --- I AN L K E affdrk DDKDRQ G NSV V T T L DS 158
Cdd:COG0768 158 LA A HVL G YVGE inggd GI G K SGLE K AY EDL L RG T ---- PGKRRVEV D AR grv I RD L G E ------ EKPPVP G KDL V L T I DS 227
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 159 K LQK V A YN AL GN ------- DR GAVV AL DPKTG NV LAM V S K P TYN PN NLA eemkkansg DLEHSI L L NRA I QG Q Y P PGSTF 231
Cdd:COG0768 228 D LQK I A EE AL KK aveeyka KS GAVV VM DPKTG EI LAM A S Y P SFD PN LFV --------- GGPDEP L R NRA V QG T Y E PGSTF 298
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 232 K VV T T A S AL DN ip GV -- QNK TF TDN G VLKF eg GG KELHNSGDASY G S L D L KK A FVV SSNV VYGT LA MD LG N DKL MKTAER 309
Cdd:COG0768 299 K PF T A A A AL EE -- GV it PDT TF DCP G YYRV -- GG RTIRDWDRGGH G T L T L TE A LAK SSNV GFYK LA LR LG I DKL YDYLKK 374
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 310 FG FNEQ ---- I P -- A N G FTIGKSTF pklt Y S G DI A RSG IGQ S t II V N P M Q M A LVAS A V AN N GV IMQ P N LV SKV VD K DG TT 383
Cdd:COG0768 375 FG LGQK tgid L P ge A S G LLPSPKRW ---- Y P G ET A TMS IGQ G - LS V T P L Q L A QAYA A I AN G GV LVK P H LV KEI VD P DG EV 449
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 384 IE v E K P KEYQ R AM S EDD A A T IKSY M KAL V DKNIQSGTWSYL ------------ Q GTGTAGKTGTADHNL pngqpapph SW 451
Cdd:COG0768 450 VK - E E P EVLR R VI S PET A E T VREG M EGV V NEPGGTARRAAI pgyrvagktgta Q VVDIGNGGYYKGRHI --------- AS 519
570 580 590 600
....*....|....*....|....*....|....*....|.
gi 1143698743 452 F IC FAPADNP KI AVAVVVE DG G --- YG AKK AA S V AGKVIN A 489
Cdd:COG0768 520 F VG FAPADNP RY AVAVVVE NP G gga YG GTV AA P V FREIME A 560
pbp2_mrdA
TIGR03423 penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 ...
12-493
5.47e-93
penicillin-binding protein 2; Members of this protein family are penicillin-binding protein 2 (PBP-2), a protein whose gene (designated pbpA or mrdA) generally is found next to the gene for RodA, a protein required for rod (bacillus) shape in many bacteria. PBP-2 acts as a transpeptidase for cell elongation (hence, rod-shape). [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 274573 [Multi-domain]
Cd Length: 592
Bit Score: 294.05
E-value: 5.47e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 12 VMMVF LF CLI A LITY ia Y F Q AFKAPDI A AKPGNQ R awa V R NRVL --- RG T I Y DRN NNVI A -------------------- 68
Cdd:TIGR03423 8 GLVLA LF GVL A ARLF -- Y L Q VIRGEEY A TLSEDN R --- I R LVPI ppp RG L I L DRN GVLL A dnrpsfsleivpekvddlda 82
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 69 ----------------------------- KSVRE K NNV ----------------------- Q KR V YP D G AVF A API G FM - 95
Cdd:TIGR03423 83 tldrlaklldldpediarflkelkrsrrf EPIPL K SDL teeevarfavnqyrlpgveiear L KR Y YP Y G ELA A HVL G YV g 162
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 96 ----------------- DSRF G G SG L E AA Y DKQ L -------- TTTSNMTASFKK L IDD P SIA nlkeaffdrkddkdrq G N 150
Cdd:TIGR03423 163 eineedlerlepanyag GDYI G K SG I E KY Y EDE L rgkpgyre VEVNARGRVIRT L SRV P PVP ---------------- G K 226
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 151 SV V T T L D SK LQ KV A YN ALG ND RGAVV AL DP K TG NV LAMVS K P TYN PN NLAEEMKKANSGD L --- EHSI LLNRAIQG Q YPP 227
Cdd:TIGR03423 227 DL V L T I D AR LQ QA A EK ALG GR RGAVV VM DP R TG EI LAMVS T P SFD PN LFVDGISSKDYKA L lnd PDRP LLNRAIQG V YPP 306
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 228 GSTFK V V TTAS AL DN ip GV -- QNKTFTDN G VLKF eg GG KELHNSGDASY G SL DL K KA FVV S SN V VYGT LA MD LG N DK LMK 305
Cdd:TIGR03423 307 GSTFK P V VALA AL EE -- GV it PETRIYCP G YFQL -- GG RRFRCWKRGGH G RV DL R KA IEE S CD V YFYQ LA LR LG I DK IAE 382
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 306 T A E RFGF NEQ -- I PAN G FTI G -------- KST F PKLT Y S GD IARSG IGQ STII V N P M Q M A LVAS A V AN N G VIMQ P N LV SK 375
Cdd:TIGR03423 383 Y A K RFGF GQK tg I DLP G EKS G lvpsrewk RKR F GQPW Y P GD TLNVS IGQ GYVL V T P L Q L A VATA A L AN G G KLYK P H LV KS 462
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 376 VV D K DG TTIEVEK P KEYQRA - M S EDDAATIKSY M KAL V dk N IQS GT WSYL --------------- Q GTGTAGKTGTADHN 439
Cdd:TIGR03423 463 IE D P DG GVVRRTE P EVLRPL p I S PENLDVVREG M RDV V -- N GPG GT ARRA rlglpykmagktgta Q VVSLKQGEKYDAEQ 540
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|....*
gi 1143698743 440 L P - NGQ pap P H SW F IC FAP A DNPKIAVAV V VE D GG Y G AKK AA SV A G K VIN A E L NK 493
Cdd:TIGR03423 541 I P e RLR --- D H AL F VA FAP Y DNPKIAVAV I VE H GG G G SSA AA PI A R K IMD A Y L LG 592
Transpeptidase
pfam00905 Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss: ...
173-487
3.33e-48
Penicillin binding protein transpeptidase domain; The active site serine (residue 337 in Swiss:P14677) is conserved in all members of this family.
Pssm-ID: 425939 [Multi-domain]
Cd Length: 296
Bit Score: 167.98
E-value: 3.33e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 173 G AV V A LDPKTG N VLAMV S KP T Y N PN NLA eemkkansgdleh SI L L NRA IQGQ Y P PGSTFK VV T TAS ALDN ip GV -- QNK T 250
Cdd:pfam00905 1 G SA V V LDPKTG E VLAMV G KP S Y D PN GFI ------------- GP L R NRA VTSR Y E PGSTFK PF T ALA ALDN -- GV lk PDE T 65
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 251 FT D NGVLKFE G GGKELH N SGDASY G sl D L KK A FVV SSN VVYGT LA MD LG N DKL MKTAER FG FNEQIPAN -- G FTI G KS T F 328
Cdd:pfam00905 66 IF D WPGKQQG G KSIGDW N QDQVGI G -- T L RQ A LEY SSN WYMQK LA QK LG A DKL RSYLKK FG YGNKTGIG lp G ENA G YL T P 143
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 329 PK L ty S G DI A RS GIG qst IIVN P M Q M A LVAS A V AN N G VIMQ P N LV SKVV DK DGTTIEVEK P keyqra M S EDD A ATI K SYM 408
Cdd:pfam00905 144 YW L -- E G AT A SF GIG --- LTIT P L Q Q A QAYA A I AN G G KLVP P H LV KSIE DK VDPKVLNKL P ------ I S KST A EKV K DML 212
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 409 KAL V DKNIQS GT WSYL ----------- Q GT G TA G KTGTADHN lpngqpapp HS WF ICF APADNPK I A V AV VVE D GG -- YG 475
Cdd:pfam00905 213 RLV V NDGTGT GT AAVP gykvagktgta Q VA G PK G GGYYDGAQ --------- IG WF VGY APADNPK Y A F AV LID D PK ry YG 283
330
....*....|..
gi 1143698743 476 A K K AA SVAGKVI 487
Cdd:pfam00905 284 G K V AA PIFKDIL 295
MrcB
COG0744 Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall ...
134-420
1.42e-46
Penicillin-binding protein 1B/1F, peptidoglycan transglycosylase/transpeptidase [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440507 [Multi-domain]
Cd Length: 630
Bit Score: 171.26
E-value: 1.42e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 134 L K E AF fd RK DD KD R Q G NSVV TTLD S KLQK V A YN A L --------- G NDRG A V V AL DPKTG N VLAMV SKPT Y NPNNL aeemk 204
Cdd:COG0744 281 L E E LL -- GE DD LY R G G LKIY TTLD P KLQK A A EK A V knvlpegkp G GLQA A L V VV DPKTG E VLAMV GGRD Y GKSQF ----- 353
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 205 kansgdlehsill NRA I Q GQYP PGSTFK VVTT A S AL DN ip G VQNK T FT D NGVLK F E GGG KELH N SGDASY G SLD L KK A FV 284
Cdd:COG0744 354 ------------- NRA T Q AKRQ PGSTFK PFVY A A AL EQ -- G YTPA T TV D DEPVT F P GGG WSPK N YDGRYR G PVT L RE A LA 418
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 285 V S S N VVYGT LA MDL G N DK LMK TA E R F G FNEQIPA N - GFTI G K S T fpkltysgdiarsgigqstii V N P MQ MA LVASAV AN 363
Cdd:COG0744 419 N S L N TPAVR LA QEV G L DK VVD TA R R L G ITSPLDP N p SLAL G T S E --------------------- V S P LE MA SAYATF AN 477
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1143698743 364 N GV IMQ P NLVS KV V D K DG TTIEVE KPK E y QRAM S EDD A ATIKSYMK alvd KNIQ SGT 420
Cdd:COG0744 478 G GV YVE P HAIT KV T D A DG KVLYEA KPK C - EQVI S PEV A YLMTDMLQ ---- DVVT SGT 529
PRK10795
PRK10795 penicillin-binding protein 2; Provisional
149-475
1.92e-34
penicillin-binding protein 2; Provisional
Pssm-ID: 236761 [Multi-domain]
Cd Length: 634
Bit Score: 136.82
E-value: 1.92e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 149 G NSVVT TLD S KLQ KVAYNA L GND R G AVV AL DP K TG NV LA M VS K P T Y N PN NLAEEMKKANSGD L --- EHSI L L NRA I QG Q Y 225
Cdd:PRK10795 248 G HDIYL TLD L KLQ QYIETL L AGS R A AVV VT DP R TG GI LA L VS T P S Y D PN LFVDGISSKDYSG L lnd PNRP L I NRA T QG V Y 327
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 226 PP G ST F K VVTTA SAL D ni P GV QNKTFT -- D N G VLKFE G GG K ELHNSGDASY G S L DLK K AFVV S SNVVYGTL A M D L G N D K L 303
Cdd:PRK10795 328 PP A ST V K PYVAV SAL S -- A GV ITRNTS lf D P G WWQLP G SE K RYRDWKKWGH G R L NVT K SLEE S ADTFFYQV A Y D M G I D R L 405
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 304 MKTAER FG FNEQ ------------ I P ANGFTIGK st F P K LT Y S GD IARS GIGQ STIIVN P M QM ALVASAVA N N G VIMQ P N 371
Cdd:PRK10795 406 SEWMGK FG YGHY tgidlaeersgn M P TREWKQKR -- F K K PW Y Q GD TIPV GIGQ GYWTAT P I QM SKALMTLI N D G IVKV P H 483
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 372 L VSKVVD k DG TTIEVEK P K E YQRA mseddaatiksymkalvdk N I Q SG T W SYLQGTGTAGK tgtadh N L PNG QP ------ 445
Cdd:PRK10795 484 L LMSTAE - DG KQVPWVQ P H E PPVG ------------------- D I H SG Y W EIAKDGMYGVA ------ N R PNG TA hkyfas 537
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1143698743 446 AP ------------------------------- P H SWFIC FAP AD NP KI AVA VVV E D GG Y G 475
Cdd:PRK10795 538 AP ykiaaksgtaqvfglkanetynahkiaerlr D H KLMTA FAP YN NP QV AVA IIL E N GG A G 598
PBP_1a_fam
TIGR02074 penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan ...
147-420
2.44e-30
penicillin-binding protein, 1A family; Bacterial that synthesize a cell wall of peptidoglycan (murein) generally have several transglycosylases and transpeptidases for the task. This family consists of bifunctional transglycosylase/transpeptidase penicillin-binding proteins (PBP). In the Proteobacteria, this family includes PBP 1A but not the paralogous PBP 1B (TIGR02071). This family also includes related proteins, often designated PBP 1A, from other bacterial lineages. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273955 [Multi-domain]
Cd Length: 531
Bit Score: 123.91
E-value: 2.44e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 147 RQ G NSVV TTLD SKL QK V A YNA L GND ------------ RG A V VA L DP K TG N V L A M V SKPT Y NPNNL aeemkkansgdlehs 214
Cdd:TIGR02074 219 TG G LKIY TTLD LDA QK A A EKV L NTG lrvagrrdgddl QA A L VA I DP D TG A V R A L V GGRD Y GKSQF --------------- 283
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 215 ill NRA I Q GQYP PGSTFK VVTT A S AL DN ip G V - QNKTFT D NGV l KFE G G G K - ELH N S G DASY G SLD L KK A FVV S S N VVYG 292
Cdd:TIGR02074 284 --- NRA T Q AKRQ PGSTFK PFVY A A AL EK -- G L t PATIVN D EPI - TYN G N G P w SPK N Y G GGYR G NVT L RQ A LAQ S R N IPAV 357
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 293 T L AMDL G N DK LMKT A E RFG FNEQIP angftigkstfpk LTY S gdiarsg IGQS T II V N P MQ MA LVASAV AN N G VIMQ P NL 372
Cdd:TIGR02074 358 R L LQEV G L DK VVAL A K RFG ITSPLD ------------- PVL S ------- LALG T VE V S P LE MA SAYAVF AN G G KYVE P HG 417
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1143698743 373 VS K V VD K DG TT I EVE KPK EY Q r AM S EDD A ATIKSYM K AL V dkni Q SGT 420
Cdd:TIGR02074 418 IR K I VD R DG KV I YEN KPK TT Q - VI S PAT A YIMTDML K GV V ---- E SGT 460
PRK15105
PRK15105 peptidoglycan synthase FtsI; Provisional
79-491
8.66e-28
peptidoglycan synthase FtsI; Provisional
Pssm-ID: 185060 [Multi-domain]
Cd Length: 578
Bit Score: 116.84
E-value: 8.66e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 79 K R V YP D G A V F A AP IGF -- M DS R f G GS G L E AAY DK Q LT TTSNMTA ---- SFKKL I D D P S IANLKE A ffdrkddkdrqg NSV 152
Cdd:PRK15105 165 R R Y YP S G E V T A HL IGF tn V DS Q - G IE G V E KSF DK W LT GQPGERI vrkd RYGRV I E D I S STDSQA A ------------ HNL 231
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 153 VTTL D SK LQ KVA Y NA L G N ------- DR G AV V AL D PK TG N VLAM VSK P T YNPNNL AEEM K K A nsgdlehsi LL NRAI QGQY 225
Cdd:PRK15105 232 ALSI D ER LQ ALV Y RE L N N avafnka ES G SA V LV D VN TG E VLAM ANS P S YNPNNL SGTP K D A --------- MR NRAI TDVF 302
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 226 P PGST F K VVTTAS AL dnipgv Q NKTFTD N G VL K --- FEGG G K E LHNS gd A S Y GS L D L KKAFVV SSNV VYGT LA MDLGNDK 302
Cdd:PRK15105 303 E PGST V K PMVVMT AL ------ Q RGVVKE N S VL N tvp YRIN G H E IKDV -- A R Y SE L T L TGVLQK SSNV GVSK LA LAMPSSA 374
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 303 L MK T AE RFG FNE qi PA N GFTI G KST -- F P KLTYSG DI A R S ---- G I G qst II V N P M Q M A L V ASAVANN G v I MQ P NLVS K v 376
Cdd:PRK15105 375 L VD T YS RFG LGK -- AT N LGLV G ERS gl Y P QKQRWS DI E R A tfsf G Y G --- LM V T P L Q L A R V YATIGSY G - I YR P LSIT K - 447
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 377 VD KD -- G TTIEV E KPKEYQRA M S E DD A -------- A T IK S Y MK A lvdkn I QS GT WSYLQ gtgtagktgtadhnl P N G QPA 446
Cdd:PRK15105 448 VD PP vp G ERVFP E SIVRTVVH M M E SV A lpggggvk A A IK G Y RI A ----- I KT GT AKKVG --------------- P D G RYI 507
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 1143698743 447 PPH - SWFICF APA DN P KI A VA VV VE D -- G G -- YG AKKA A S V A G KVINAE L 491
Cdd:PRK15105 508 NKY i AYTAGV APA SQ P RF A LV VV IN D pq A G ky YG GAVS A P V F G AIMGGV L 557
MrcA
COG5009 Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
173-480
5.34e-17
Membrane carboxypeptidase/penicillin-binding protein [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 444033 [Multi-domain]
Cd Length: 785
Bit Score: 84.06
E-value: 5.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 173 GA V VALDP K TG N VLA M V skptynpnnlaeemkkans G -- D L E H S IL l NRA I Q GQYP PGS T FK VVTT A S ALDN ip G vqnkt 250
Cdd:COG5009 423 GA L VALDP H TG A VLA L V ------------------- G gf D F E Q S KF - NRA T Q AKRQ PGS S FK PFVY A A ALDN -- G ----- 475
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 251 F T ------ D NGVLKFE GGG KEL --- H N SGDAS YG SLD L KK A FVV S S N V V YGT L AM D L G N D KLMKT AERFG FNEQI P A N gf 321
Cdd:COG5009 476 Y T patiin D APIVFDD GGG GGV wrp K N YSGKF YG PTT L RE A LEK S R N L V TVR L LQ D V G I D YVIDY AERFG IYSKL P P N -- 553
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 322 tigkstfpk L TYS gdiarsg I G QST ii V N P MQ MA LVASAV AN N G VIMQ P N L VSKVV D KD G TT I EVEK P K ----------- 390
Cdd:COG5009 554 --------- L SLA ------- L G SGE -- V T P LE MA RAYAVF AN G G YRVE P Y L IDRIE D RN G KV I YRAD P A racedcdaaew 615
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 391 --------- EYQRAMSEDD A ATIK S YMKA lvdk NI Q S GT WSYLQGT G TAGK -- T ---- GTA D hnlpngqpapph S WF IC F 455
Cdd:COG5009 616 dgaeprlpd PAEQVIDPRT A YQMT S MLRG ---- VV Q R GT GRRARAL G RDIA gk T gttn DSK D ------------ A WF VG F 679
330 340 350
....*....|....*....|....*....|...
gi 1143698743 456 apad N P KIAVA V V V -------- ED G GY G AKK A A 480
Cdd:COG5009 680 ---- T P DLVAG V W V gfddprsl GR G ET G GRA A L 708
mrcA
PRK11636 penicillin-binding protein 1a; Provisional
174-390
2.12e-05
penicillin-binding protein 1a; Provisional
Pssm-ID: 183248 [Multi-domain]
Cd Length: 850
Bit Score: 47.05
E-value: 2.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 174 A V V ALD P KT G N V L A M V SKPTY N PNNL aeemkkansgdlehsill NRA I Q GQYPP GS TF K VVTTAS A L D N ip G VQNKT - FT 252
Cdd:PRK11636 428 A L V SIN P QN G A V M A L V GGFDF N QSKF ------------------ NRA T Q ALRQV GS NI K PFLYTA A M D K -- G LTLAS m LN 487
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1143698743 253 D NGVLKFE - G G G KELH -- NS GDASY G SLD L KKAFVV S S NVV YGTLAMDL G N D KLMKTAE RFGF NE Q -- IPANGFTI G KST 327
Cdd:PRK11636 488 D VPISRWD a G A G SDWR pk NS PPQYA G PIR L RQGLGQ S K NVV MVRAMRAM G V D YAAEYLQ RFGF PA Q ni VHTESLAL G SAS 567
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1143698743 328 F pkltysgdiarsgigqstiiv N PMQ M A LVASAV AN N G VIMQ P NLV SK VVDKD G TT I EVE KPK 390
Cdd:PRK11636 568 F --------------------- T PMQ V A RGYAVM AN G G FLVD P YFI SK IENDQ G GV I FEA KPK 609
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
