NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|114187671|gb|EAU29371|]
View 

conserved hypothetical protein [Aspergillus terreus NIH2624]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
729-1150 2.55e-140

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 432.03  E-value: 2.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  729 AFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGP 808
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  809 ICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEQTLEG 888
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  889 HSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAvkqaftvqghLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISL 968
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  969 WDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTEALQSSLieetppeviDGHSGTVGIVAFSFDKK 1048
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL---------TGHSGGVNSVAFSPDGK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1049 ILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFS 1128
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                         410       420
                  ....*....|....*....|..
gi 114187671 1129 PGCQLLASGSTDNTVKVWNSAD 1150
Cdd:COG2319   382 PDGRTLASGSADGTVRLWDLAT 403
CysC super family cl42401
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 181-209 4.58e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


The actual alignment was detected with superfamily member COG0529:

Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 39.69  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*....
gi 114187671  181 CIFWLNGMAGTGKSTISRTVAGRLKRQDR 209
Cdd:COG0529    17 FVVWFTGLSGSGKSTLANALERRLFERGR 45
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
 184-338 8.71e-03

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member pfam05729:

Pssm-ID: 476819 [Multi-domain]  Cd Length: 166  Bit Score: 38.44  E-value: 8.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   184 WLNGMAGTGKSTISRTVA-----GRLKRQDRLAasFFFKRGE-QDRGNAKLLFSTIAKQLgssmpqlsldiqnaieddPD 257
Cdd:pfam05729    4 ILQGEAGSGKTTLLQKLAllwaqGKLPQGFDFV--FFLPCRElSRSGNARSLADLLFSQW------------------PE 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   258 ISDRVlREQFEKLILQPLSAakhcpntimVVVIDALDECDRTDD--------IQVILHLLPRVQQSTSMrlrFLITSRP- 328
Cdd:pfam05729   64 PAAPV-SEVWAVILELPERL---------LLILDGLDELVSDLGqldgpcpvLTLLSSLLRKKLLPGAS---LLLTVRPd 130

                          170
                   ....*....|.
gi 114187671   329 -VLPIKSGFER 338
Cdd:pfam05729  131 aLRDLRRGLEE 141
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
729-1150 2.55e-140

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 432.03  E-value: 2.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  729 AFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGP 808
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  809 ICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEQTLEG 888
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  889 HSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAvkqaftvqghLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISL 968
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  969 WDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTEALQSSLieetppeviDGHSGTVGIVAFSFDKK 1048
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL---------TGHSGGVNSVAFSPDGK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1049 ILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFS 1128
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                         410       420
                  ....*....|....*....|..
gi 114187671 1129 PGCQLLASGSTDNTVKVWNSAD 1150
Cdd:COG2319   382 PDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 714-1012 7.38e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 327.37  E-value: 7.38e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  714 ELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDA 793
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  794 VTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIK 873
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  874 LWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQaftvqghlrnTVVGHQASVGAVAFSPD 953
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG----------TLRGHENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114187671  954 GRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWD 1012
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 801-1054 4.40e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 83.60  E-value: 4.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  801 DFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTgSLKRTLNGHTQPVQAVAFSPNGEV---------LVSGSQDKT 871
Cdd:PLN00181  478 DLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES-IIKDGRDIHYPVVELASRSKLSGIcwnsyiksqVASSNFEGV 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  872 IKLWATTPGSLEQTLEGHSDWVRAIAFSSCG-RLIASGSHDGTVRVWDAGAGavkqaftvqghLRNTVVGHQASVGAVAF 950
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG-----------VSIGTIKTKANICCVQF 625

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  951 SPD-GRLLACGTHDSTISLWDITTGALR-TTLAGHIFSVGALAFSpDSQLLASGSFDSTAKLWDISTEAlqsSLIEETPP 1028
Cdd:PLN00181  626 PSEsGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSI---SGINETPL 701

                         250       260
                  ....*....|....*....|....*.
gi 114187671 1029 EVIDGHSGTVGIVAFSFDKKILASGS 1054
Cdd:PLN00181  702 HSFMGHTNVKNFVGLSVSDGYIATGS 727
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 879-918 4.15e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.86  E-value: 4.15e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    879 PGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWD 918
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
880-918 9.11e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 57.74  E-value: 9.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   880 GSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWD 918
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 181-209 4.58e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 39.69  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*....
gi 114187671  181 CIFWLNGMAGTGKSTISRTVAGRLKRQDR 209
Cdd:COG0529    17 FVVWFTGLSGSGKSTLANALERRLFERGR 45
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 184-338 8.71e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 38.44  E-value: 8.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   184 WLNGMAGTGKSTISRTVA-----GRLKRQDRLAasFFFKRGE-QDRGNAKLLFSTIAKQLgssmpqlsldiqnaieddPD 257
Cdd:pfam05729    4 ILQGEAGSGKTTLLQKLAllwaqGKLPQGFDFV--FFLPCRElSRSGNARSLADLLFSQW------------------PE 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   258 ISDRVlREQFEKLILQPLSAakhcpntimVVVIDALDECDRTDD--------IQVILHLLPRVQQSTSMrlrFLITSRP- 328
Cdd:pfam05729   64 PAAPV-SEVWAVILELPERL---------LLILDGLDELVSDLGqldgpcpvLTLLSSLLRKKLLPGAS---LLLTVRPd 130

                          170
                   ....*....|.
gi 114187671   329 -VLPIKSGFER 338
Cdd:pfam05729  131 aLRDLRRGLEE 141
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
729-1150 2.55e-140

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 432.03  E-value: 2.55e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  729 AFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGP 808
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  809 ICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEQTLEG 888
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  889 HSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAvkqaftvqghLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISL 968
Cdd:COG2319   161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK----------LLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  969 WDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTEALQSSLieetppeviDGHSGTVGIVAFSFDKK 1048
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTL---------TGHSGGVNSVAFSPDGK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1049 ILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFS 1128
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFS 381

                         410       420
                  ....*....|....*....|..
gi 114187671 1129 PGCQLLASGSTDNTVKVWNSAD 1150
Cdd:COG2319   382 PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
712-1106 1.45e-137

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 424.71  E-value: 1.45e-137
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  712 GTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLW 791
Cdd:COG2319    26 GALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLW 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  792 DAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKT 871
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  872 IKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQAFTvqghlrntvvGHQASVGAVAFS 951
Cdd:COG2319   186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLT----------GHSGSVRSVAFS 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  952 PDGRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTEALQSSLieetppevi 1031
Cdd:COG2319   256 PDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL--------- 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114187671 1032 DGHSGTVGIVAFSFDKKILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDT 1106
Cdd:COG2319   327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
699-1064 2.53e-128

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 400.44  E-value: 2.53e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  699 SLIRRLPKVENLWGTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRL 778
Cdd:COG2319    55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  779 LASGSQDSTVKLWDAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSP 858
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  859 NGEVLVSGSQDKTIKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQAFTvqghlrntv 938
Cdd:COG2319   215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT--------- 285

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  939 vGHQASVGAVAFSPDGRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTeal 1018
Cdd:COG2319   286 -GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLAT--- 361

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 114187671 1019 qsslieETPPEVIDGHSGTVGIVAFSFDKKILASGSIDKTVKLWDV 1064
Cdd:COG2319   362 ------GELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
771-1175 2.30e-125

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 392.35  E-value: 2.30e-125
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  771 AFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQP 850
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  851 VQAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAvkqaftv 930
Cdd:COG2319    81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGK------- 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  931 qghLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKL 1010
Cdd:COG2319   154 ---LLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRL 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1011 WDISTEALQSSLieetppeviDGHSGTVGIVAFSFDKKILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGR 1090
Cdd:COG2319   231 WDLATGKLLRTL---------TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGK 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1091 LLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFSPGCQLLASGSTDNTVKVWNSADGTLKQDLSV-KGVVTDMKFS 1169
Cdd:COG2319   302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGAVTSVAFS 381


                  ....*.
gi 114187671 1170 IDGATL 1175
Cdd:COG2319   382 PDGRTL 387
WD40 COG2319
WD40 repeat [General function prediction only];
710-1015 3.94e-119

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 375.79  E-value: 3.94e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  710 LW----GTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQD 785
Cdd:COG2319   104 LWdlatGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  786 STVKLWDAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVS 865
Cdd:COG2319   184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  866 GSQDKTIKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQAFTvqghlrntvvGHQASV 945
Cdd:COG2319   264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT----------GHTGAV 333

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  946 GAVAFSPDGRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDIST 1015
Cdd:COG2319   334 RSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 714-1012 7.38e-103

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 327.37  E-value: 7.38e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  714 ELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDA 793
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  794 VTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIK 873
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  874 LWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQaftvqghlrnTVVGHQASVGAVAFSPD 953
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG----------TLRGHENGVNSVAFSPD 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114187671  954 GRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWD 1012
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 840-1147 4.54e-96

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 308.88  E-value: 4.54e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  840 LKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDA 919
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  920 GagavkqaftvQGHLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLL 999
Cdd:cd00200    81 E----------TGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1000 ASGSFDSTAKLWDISTEALQsslieetppEVIDGHSGTVGIVAFSFDKKILASGSIDKTVKLWDVITGSLLYTLEGHLDL 1079
Cdd:cd00200   151 ASSSQDGTIKLWDLRTGKCV---------ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114187671 1080 IWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFSPGCQLLASGSTDNTVKVWN 1147
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 712-970 2.78e-86

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 281.92  E-value: 2.78e-86
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  712 GTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLW 791
Cdd:cd00200    41 GELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVW 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  792 DAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKT 871
Cdd:cd00200   121 DVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  872 IKLWATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQAFTvqghlrntvvGHQASVGAVAFS 951
Cdd:cd00200   201 IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLS----------GHTNSVTSLAWS 270

                         250
                  ....*....|....*....
gi 114187671  952 PDGRLLACGTHDSTISLWD 970
Cdd:cd00200   271 PDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 882-1175 2.62e-83

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 273.83  E-value: 2.62e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  882 LEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDagagavkqafTVQGHLRNTVVGHQASVGAVAFSPDGRLLACGT 961
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD----------LETGELLRTLKGHTGPVRDVAASADGTYLASGS 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  962 HDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDISTEALQSslieetppeVIDGHSGTVGIV 1041
Cdd:cd00200    71 SDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT---------TLRGHTDWVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1042 AFSFDKKILASGSIDKTVKLWDVITGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGA 1121
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114187671 1122 IRAVAFSPGCQLLASGSTDNTVKVWNSADGTLKQDLS-VKGVVTDMKFSIDGATL 1175
Cdd:cd00200   222 VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSgHTNSVTSLAWSPDGKRL 276
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 801-1054 4.40e-16

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 83.60  E-value: 4.40e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  801 DFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTgSLKRTLNGHTQPVQAVAFSPNGEV---------LVSGSQDKT 871
Cdd:PLN00181  478 DLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECES-IIKDGRDIHYPVVELASRSKLSGIcwnsyiksqVASSNFEGV 556

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  872 IKLWATTPGSLEQTLEGHSDWVRAIAFSSCG-RLIASGSHDGTVRVWDAGAGavkqaftvqghLRNTVVGHQASVGAVAF 950
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG-----------VSIGTIKTKANICCVQF 625

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  951 SPD-GRLLACGTHDSTISLWDITTGALR-TTLAGHIFSVGALAFSpDSQLLASGSFDSTAKLWDISTEAlqsSLIEETPP 1028
Cdd:PLN00181  626 PSEsGRSLAFGSADHKVYYYDLRNPKLPlCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSMSI---SGINETPL 701

                         250       260
                  ....*....|....*....|....*.
gi 114187671 1029 EVIDGHSGTVGIVAFSFDKKILASGS 1054
Cdd:PLN00181  702 HSFMGHTNVKNFVGLSVSDGYIATGS 727
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 731-917 5.71e-14

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 76.66  E-value: 5.71e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  731 SPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSG-RLLASGSQDSTVKLWDAVTGAPLNDFCGHSGpI 809
Cdd:PLN00181  542 SYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-I 620

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  810 CSVDF-SPSGDLVVSGSVDCTLRLWDVTTGSLKR-TLNGHTQPVQAVAFSpNGEVLVSGSQDKTIKLW---ATTPGSLEQ 884
Cdd:PLN00181  621 CCVQFpSESGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWdlsMSISGINET 699

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 114187671  885 TLE---GHSDWVRAIAFSSCGRLIASGSHDGTVRVW 917
Cdd:PLN00181  700 PLHsfmGHTNVKNFVGLSVSDGYIATGSETNEVFVY 735
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 931-1207 1.02e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 75.89  E-value: 1.02e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  931 QGHLRNTvvghQASVGAVAFSPDGRLLACGTHDSTISLWD--------------ITTGALRTTLAGHIFSvgalafSPDS 996
Cdd:PLN00181  476 QGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFEcesiikdgrdihypVVELASRSKLSGICWN------SYIK 545

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  997 QLLASGSFDSTAKLWDISTEALQSSLIEetppevidgHSGTVGIVAFS-FDKKILASGSIDKTVKLWDVITGSLLYTLEG 1075
Cdd:PLN00181  546 SQVASSNFEGVVQVWDVARSQLVTEMKE---------HEKRVWSIDYSsADPTLLASGSDDGSVKLWSINQGVSIGTIKT 616

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1076 HLDlIWAVEFSPD-GRLLASGSNDGAIKLWDTYNGALQH-TLDGHSGAIRAVAFSPGCQLLASgSTDNTVKVWN---SAD 1150
Cdd:PLN00181  617 KAN-ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLcTMIGHSKTVSYVRFVDSSTLVSS-STDNTLKLWDlsmSIS 694

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114187671 1151 GTLKQDL-------SVKGV----VTDMKFSIDGATLETSLGQLSIESSPSNYTFVPTLPTTELSIEDS 1207
Cdd:PLN00181  695 GINETPLhsfmghtNVKNFvglsVSDGYIATGSETNEVFVYHKAFPMPVLSYKFKTIDPVSGLEVDDA 762
PTZ00421 PTZ00421
coronin; Provisional
 990-1121 1.93e-13

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 74.54  E-value: 1.93e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  990 LAFSP-DSQLLASGSFDSTAKLWDISTEALQSSLIEetPPEVIDGHSGTVGIVAFSFDKK-ILASGSIDKTVKLWDVITG 1067
Cdd:PTZ00421   81 VAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISD--PIVHLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERG 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 114187671 1068 SLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGA 1121
Cdd:PTZ00421  159 KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASA 212
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 851-1096 5.11e-13

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 73.58  E-value: 5.11e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  851 VQAVAFSPNGEVLVSGSQDKTIKLWATTpGSLEQTLEGHSDWVRAIAFSSCGRL---------IASGSHDGTVRVWDAGa 921
Cdd:PLN00181  486 VCAIGFDRDGEFFATAGVNKKIKIFECE-SIIKDGRDIHYPVVELASRSKLSGIcwnsyiksqVASSNFEGVVQVWDVA- 563

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  922 gavkqaftvQGHLRNTVVGHQASVGAVAFSP-DGRLLACGTHDSTISLWDITTGALRTTLAGHIfSVGALAFSPDS-QLL 999
Cdd:PLN00181  564 ---------RSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKA-NICCVQFPSESgRSL 633

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1000 ASGSFDSTAKLWDISTEALqsslieetPPEVIDGHSGTVGIVAFsFDKKILASGSIDKTVKLWDV------ITGSLLYTL 1073
Cdd:PLN00181  634 AFGSADHKVYYYDLRNPKL--------PLCTMIGHSKTVSYVRF-VDSSTLVSSSTDNTLKLWDLsmsisgINETPLHSF 704

                         250       260
                  ....*....|....*....|...
gi 114187671 1074 EGHLDLIWAVEFSPDGRLLASGS 1096
Cdd:PLN00181  705 MGHTNVKNFVGLSVSDGYIATGS 727
PTZ00421 PTZ00421
coronin; Provisional
 720-877 3.82e-12

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 70.31  E-value: 3.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  720 GHTGPIGAVAFSPID-QVLATCSHDKTIKFWDTTTGSLRQSLS-------GHSDWVRAIAFSSSGR-LLASGSQDSTVKL 790
Cdd:PTZ00421   73 GQEGPIIDVAFNPFDpQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  791 WDAVTGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTLNGH-TQPVQAVAFSPNGEVLV----S 865
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHaSAKSQRCLWAKRKDLIItlgcS 232

                         170
                  ....*....|..
gi 114187671  866 GSQDKTIKLWAT 877
Cdd:PTZ00421  233 KSQQRQIMLWDT 244
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 879-918 4.15e-11

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 58.86  E-value: 4.15e-11
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    879 PGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWD 918
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
880-918 9.11e-11

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 57.74  E-value: 9.11e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   880 GSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWD 918
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 753-792 1.60e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 57.32  E-value: 1.60e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    753 TGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWD 792
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 837-875 1.94e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.94  E-value: 1.94e-10
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114187671    837 TGSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLW 875
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1066-1105 3.29e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 56.17  E-value: 3.29e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671   1066 TGSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWD 1105
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
754-792 6.37e-10

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 55.43  E-value: 6.37e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   754 GSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWD 792
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
1067-1105 1.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 54.66  E-value: 1.18e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671  1067 GSLLYTLEGHLDLIWAVEFSPDGRLLASGSNDGAIKLWD 1105
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 712-750 1.37e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 1.37e-09
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114187671    712 GTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWD 750
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
838-875 2.14e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.89  E-value: 2.14e-09
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 114187671   838 GSLKRTLNGHTQPVQAVAFSPNGEVLVSGSQDKTIKLW 875
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1108-1147 2.18e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.86  E-value: 2.18e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671   1108 NGALQHTLDGHSGAIRAVAFSPGCQLLASGSTDNTVKVWN 1147
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 795-834 3.66e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 3.66e-09
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    795 TGAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWD 834
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
1109-1147 3.86e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 3.86e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671  1109 GALQHTLDGHSGAIRAVAFSPGCQLLASGSTDNTVKVWN 1147
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
796-834 5.43e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 5.43e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   796 GAPLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWD 834
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
712-750 5.99e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 52.73  E-value: 5.99e-09
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   712 GTELQTLEGHTGPIGAVAFSPIDQVLATCSHDKTIKFWD 750
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 731-979 9.71e-09

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 58.54  E-value: 9.71e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   731 SPIDQVLATCSH-DKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWDAVTG------------- 796
Cdd:pfam20426   90 TPSENFLISCGNwENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGrssekrsrntqte 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   797 ----------APLNDFCGHSGPICSVDFSPSGDLVVSGSVDCTLRLWDVTTGSLKRTL-NGHTQPVQAVAFSPNGEVLVS 865
Cdd:pfam20426  170 fprkdhviaeTPFHILCGHDDIITCLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIrHPSGCPLSKLVASRHGRIVLY 249

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   866 GSQDKTIKLWattpgsleqTLEGhsdwvRAIAFSSC-GRLIA---SGSHDGTVRVWDAGAGAVKQAFTVQGHLRNTVVGh 941
Cdd:pfam20426  250 ADDDLSLHLY---------SING-----KHIASSESnGRLNCielSSCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIG- 314

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 114187671   942 qASVGAVAFSPDGRLLAcGTHDSTISLWDITTGALRTT 979
Cdd:pfam20426  315 -KIITSLTVTPEECFLA-GTKDGSLLVYSIENPQLRKA 350
PTZ00421 PTZ00421
coronin; Provisional
 804-968 2.23e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 58.37  E-value: 2.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  804 GHSGPICSVDFSPSGDL-VVSGSVDCTLRLWDVTTGSLKRT-------LNGHTQPVQAVAFSPNGE-VLVSGSQDKTIKL 874
Cdd:PTZ00421   73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLASAGADMVVNV 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  875 WATTPGSLEQTLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAgagavkqaftvqghLRNTVVghqASVGAVAFSPDG 954
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP--------------RDGTIV---SSVEAHASAKSQ 215

                         170
                  ....*....|....
gi 114187671  955 RLLACGTHDSTISL 968
Cdd:PTZ00421  216 RCLWAKRKDLIITL 229
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
734-865 2.34e-08

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 56.24  E-value: 2.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  734 DQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWvRAIAFSSSG-RLLASGSQDSTVKLWDAVTGAPLNDFCGHSGPiCSV 812
Cdd:COG3391    80 RRLYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIPVGAGP-HGI 157

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114187671  813 DFSPSGDLVV-----SGSVDCTLRLWDVTTGSLKRTLNGHTQPVqAVAFSPNG-EVLVS 865
Cdd:COG3391   158 AVDPDGKRLYvansgSNTVSVIVSVIDTATGKVVATIPVGGGPV-GVAVSPDGrRLYVA 215
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 973-1012 1.62e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 1.62e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    973 TGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWD 1012
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 931-970 2.30e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 2.30e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114187671    931 QGHLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISLWD 970
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
974-1012 2.45e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 2.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   974 GALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWD 1012
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
834-1163 3.25e-07

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 53.76  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  834 DVTTGSLKR--TLNGHTQPvQAVAFSPNGEVL--VSGSQDKTIKLWATTP--GSLE----QTLEGHSdwVRAIAFSSCGR 903
Cdd:COG2706    29 DTATGELTLlgLVAALGNP-SFLALSPDGRFLyaVNEVDDGGVSAFRIDPadGTLTllntVSSGGAS--PCHLSVDPDGR 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  904 LIASGS-HDGTVRVW----DAGAGAVKQAFTVQGHLRNTVVGHQASVGAVAFSPDGR-LLAC--GTHdsTISLW--DITT 973
Cdd:COG2706   106 FLFVANyGGGSVSVFpidaDGSLGEPVQVIQHEGSGPNPERQEGPHAHSVVFDPDGRfLYVPdlGTD--RIYVYrlDPAT 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  974 GALrtTLAGHI-FSVGA----LAFSPDSQLLAsgsfdstaklwdistealqsslieetppeVIDGHSGTVgiVAFSFDKK 1048
Cdd:COG2706   184 GKL--PEPPEVsLPPGSgprhLAFHPNGRFAY-----------------------------VINELDSTV--SVYAYDAA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1049 ilasgsiDKTVKLWDVITgsllyTL-EGHLDLIWA--VEFSPDGRLL-AS--GSNDGAIKLWDTYNGALQHTLDGHSGAI 1122
Cdd:COG2706   231 -------TGTLTLIQTVS-----TLpEDFTGENWAadIHISPDGRFLyVSnrGHNSIAVFAIDADGGKLTLVGHVPTGGK 298

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*....
gi 114187671 1123 --RAVAFSP-GCQLLASGSTDNTVKVW--NSADGTLK---QDLSVKGVV 1163
Cdd:COG2706   299 wpRDFAIDPdGRFLLVANQKSDNITVFriDADTGKLTptgRSVPVPSPV 347
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
769-974 3.32e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 52.77  E-value: 3.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  769 AIAFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGPICSVDFSPSGD----LVVSGSVDCTLRLWDVTTGSLKRTL 844
Cdd:COG3391    27 ALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRVSVIDLATGKVVATI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  845 NGHTQPvQAVAFSPNG-EVLVSGSQDKTIKLWATTPGSLEQTLEGhSDWVRAIAFSSCG-RLIASGSHDGT----VRVWD 918
Cdd:COG3391   107 PVGGGP-RGLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAVDPDGkRLYVANSGSNTvsviVSVID 184

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114187671  919 AGAGAVKQAFTVQGHlrntvvghqasVGAVAFSPDGRLL--ACGTHDST------ISLWDITTG 974
Cdd:COG3391   185 TATGKVVATIPVGGG-----------PVGVAVSPDGRRLyvANRGSNTSnggsntVSVIDLATL 237
WD40 pfam00400
WD domain, G-beta repeat;
932-970 4.00e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.34  E-value: 4.00e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 114187671   932 GHLRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISLWD 970
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 718-792 1.69e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.20  E-value: 1.69e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114187671  718 LEGHTGPIGAVAFSP-IDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWD 792
Cdd:PTZ00421  121 LQGHTKKVGIVSFHPsAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WD40 pfam00400
WD domain, G-beta repeat;
1030-1063 1.98e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.98e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 114187671  1030 VIDGHSGTVGIVAFSFDKKILASGSIDKTVKLWD 1063
Cdd:pfam00400    6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
903-1109 2.01e-06

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 2.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  903 RLIASGSHDGTVRVWDAGAGAVKQAFTVQGHLRNtvvghqasvgaVAFSPDG-RLLACGTHDSTISLWDITTGALRTTla 981
Cdd:COG3391    81 RLYVANSGSGRVSVIDLATGKVVATIPVGGGPRG-----------LAVDPDGgRLYVADSGNGRVSVIDTATGKVVAT-- 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  982 ghiFSVGA----LAFSPDSQLLAsgsfdstaklwdistealqsslieetppeVIDGHSGTVGIVafsfdkkilasgsidk 1057
Cdd:COG3391   148 ---IPVGAgphgIAVDPDGKRLY-----------------------------VANSGSNTVSVI---------------- 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1058 tVKLWDVITGSLLYTLEGHlDLIWAVEFSPDGRLL--------ASGSNDGAIKLWDTYNG 1109
Cdd:COG3391   180 -VSVIDTATGKVVATIPVG-GGPVGVAVSPDGRRLyvanrgsnTSNGGSNTVSVIDLATL 237
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 1030-1063 4.19e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 4.19e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 114187671   1030 VIDGHSGTVGIVAFSFDKKILASGSIDKTVKLWD 1063
Cdd:smart00320    7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 762-966 6.95e-06

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 49.24  E-value: 6.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  762 GHSDWVRAIAFSSSGRLLASGSQDSTVKLWD------AVTGAPLNDFCGHSGPiCSVDFSPSGDLVVSGSVDCTLRLWD- 834
Cdd:cd05819    52 GQFNEPAGVAVDSDGNLYVADTGNHRIQKFDpdgnflASFGGSGDGDGEFNGP-RGIAVDSSGNIYVADTGNHRIQKFDp 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  835 -----VTTGSLKRTLNGHTQPVqAVAFSPNGEVLVS----------GSQDKTIKLWATTpgsleQTLEGHSDWVRAIAFS 899
Cdd:cd05819   131 dgeflTTFGSGGSGPGQFNGPT-GVAVDSDGNIYVAdtgnhriqvfDPDGNFLTTFGST-----GTGPGQFNYPTGIAVD 204

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114187671  900 SCGRLIASGSHDGTVRVWDAGAGAvkqaFTVQGHLRNTVVGHQASVGaVAFSPDGRLLACGTHDSTI 966
Cdd:cd05819   205 SDGNIYVADSGNNRVQVFDPDGAG----FGGNGNFLGSDGQFNRPSG-LAVDSDGNLYVADTGNNRI 266
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 852-1015 7.26e-06

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 50.42  E-value: 7.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  852 QAVAFSPNGEVLVSGSQDKTIKLWATTPGSLEqtleghsdwvRAIAFSSCGRLIASGSH-DGTVRVW--DA-GAGAVKQa 927
Cdd:COG4946   314 KRVAFEARGEVFTVPAEKGPTRNLTNTPGVRE----------RLPAWSPDGKSIAYFSDaSGEYELYiaPAdGSGEPKQ- 382

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  928 FTVQGHLRNTvvghqasvgAVAFSPDGRLLACGTHDSTISLWDITTGALRT----TLAGHIFSvgaLAFSPDSQLLA--- 1000
Cdd:COG4946   383 LTLGDLGRVF---------NPVWSPDGKKIAFTDNRGRLWVVDLASGKVRKvdtdGYGDGISD---LAWSPDSKWLAysk 450

                         170
                  ....*....|....*.
gi 114187671 1001 -SGSFDSTAKLWDIST 1015
Cdd:COG4946   451 pGPNQLSQIFLYDVET 466
PTZ00421 PTZ00421
coronin; Provisional
 1028-1153 1.02e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1028 PEVIDGHSGTVGIVAFS-FDKKILASGSIDKTVKLWDVITGSL-------LYTLEGHLDLIWAVEFSPDGR-LLASGSND 1098
Cdd:PTZ00421   68 PPILLGQEGPIIDVAFNpFDPQKLFTASEDGTIMGWGIPEEGLtqnisdpIVHLQGHTKKVGIVSFHPSAMnVLASAGAD 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114187671 1099 GAIKLWDTYNGALQHTLDGHSGAIRAVAFSPGCQLLASGSTDNTVKVWNSADGTL 1153
Cdd:PTZ00421  148 MVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTI 202
PTZ00420 PTZ00420
coronin; Provisional
 897-1016 2.09e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.79  E-value: 2.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  897 AFSSCGrlIASGShdGTVRV-WDAGAGAVKQAFTVQGHLRNTVV----GHQASVGAVAFSP-DGRLLACGTHDSTISLWD 970
Cdd:PTZ00420   28 VIDSCG--IACSS--GFVAVpWEVEGGGLIGAIRLENQMRKPPViklkGHTSSILDLQFNPcFSEILASGSEDLTIRVWE 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114187671  971 I--------TTGALRTTLAGHIFSVGALAFSP-DSQLLASGSFDSTAKLWDISTE 1016
Cdd:PTZ00420  104 IphndesvkEIKDPQCILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIWDIENE 158
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 759-1006 4.35e-05

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.54  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  759 SLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWD------AVTGAPLNDFCGHSGPiCSVDFSPSGDLVVSGSVDCTLRL 832
Cdd:cd05819     2 TGPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDpdgnfiTSFGSFGSGDGQFNEP-AGVAVDSDGNLYVADTGNHRIQK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  833 WD------VTTGSLKRTLNGHTQPvQAVAFSPNGEVLVSGSQDKTIKLW---------ATTPGSLEQTLEGhsdwVRAIA 897
Cdd:cd05819    81 FDpdgnflASFGGSGDGDGEFNGP-RGIAVDSSGNIYVADTGNHRIQKFdpdgeflttFGSGGSGPGQFNG----PTGVA 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  898 FSSCGRLIASGSHDGTVRVWDAGAGAVKQAFTvqghlRNTVVGHQASVGAVAFSPDGRLLACGTHDSTISLWD------I 971
Cdd:cd05819   156 VDSDGNIYVADTGNHRIQVFDPDGNFLTTFGS-----TGTGPGQFNYPTGIAVDSDGNIYVADSGNNRVQVFDpdgagfG 230

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 114187671  972 TTGALRTTLAGHIFSVGaLAFSPDSQLLASGSFDS 1006
Cdd:cd05819   231 GNGNFLGSDGQFNRPSG-LAVDSDGNLYVADTGNN 264
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
713-956 4.56e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 46.55  E-value: 4.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  713 TELQTLEGHTGPIGaVAFSPIDQVLATCSHDKTIKFWDTTTGSLRQSLSGHSDWVRAIAFSSSGRLLASGSQDSTVKLWD 792
Cdd:COG4257     8 TEYPVPAPGSGPRD-VAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPDGNLWFTDNGNNRIGRID 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  793 AVTGA----PLNDfcGHSGPIcSVDFSPSGDLVVSGSVDCTLRLWDVTTG--SLKRTLNGHTQPVqAVAFSPNGEVLVSG 866
Cdd:COG4257    87 PKTGEittfALPG--GGSNPH-GIAFDPDGNLWFTDQGGNRIGRLDPATGevTEFPLPTGGAGPY-GIAVDPDGNLWVTD 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  867 SQ-DKTIKLWATTpGSLEQ-TLEGHSDWVRAIAFSSCGRLIASGSHDGTVRVWDAGAGAVKQAftvqghlrnTVVGHQAS 944
Cdd:COG4257   163 FGaNAIGRIDPDT-GTLTEyALPTPGAGPRGLAVDPDGNLWVADTGSGRIGRFDPKTGTVTEY---------PLPGGGAR 232

                         250
                  ....*....|..
gi 114187671  945 VGAVAFSPDGRL 956
Cdd:COG4257   233 PYGVAVDGDGRV 244
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 956-1058 6.93e-05

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 46.60  E-value: 6.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   956 LLACGTHDSTISLWDITTGALRTTLAGHIFSVGALAFSPDSQLLASGSFDSTAKLWDIS-------------TEALQ-SS 1021
Cdd:pfam20426   96 LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLrgrssekrsrntqTEFPRkDH 175

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 114187671  1022 LIEETPPEVIDGHSGTVGIVAFSFDKKILASGSIDKT 1058
Cdd:pfam20426  176 VIAETPFHILCGHDDIITCLYVSVELDIVISGSKDGT 212
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 902-1091 8.09e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 46.04  E-value: 8.09e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  902 GRLIASGSHDGTVRVWDAGAGAVkqaftvqghlrNTVVGHQASVGAVAFSPDGRLLACGtHDSTISLWDITTGALrTTLA 981
Cdd:COG3386    19 GRLYWVDIPGGRIHRYDPDGGAV-----------EVFAEPSGRPNGLAFDPDGRLLVAD-HGRGLVRFDPADGEV-TVLA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  982 GHIFSVGA----LAFSPDSQLLAS--GSFDSTAKLWDISTEAlqsslieeTPPEVIDGHSGTVGIvAFSFDkkilasgsi 1055
Cdd:COG3386    86 DEYGKPLNrpndGVVDPDGRLYFTdmGEYLPTGALYRVDPDG--------SLRVLADGLTFPNGI-AFSPD--------- 147

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 114187671 1056 dktvklwdvitGSLLYTLEGHLDLIWAVEFSPDGRL 1091
Cdd:COG3386   148 -----------GRTLYVADTGAGRIYRFDLDADGTL 172
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 1085-1128 1.15e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 42.27  E-value: 1.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 114187671  1085 FSPDGRLLASGSNDGAIKLWDTYNGALQHTLDGHSGAIRAVAFS 1128
Cdd:pfam12894   46 WRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 907-1012 1.21e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.04  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  907 SGSHDGTVRVWDAGAGAVKQAFTVQ-GHLRntvvGHQASVGAVAFSPDGR-LLACGTHDSTISLWDITTGALRTTLAGHI 984
Cdd:PTZ00421   93 TASEDGTIMGWGIPEEGLTQNISDPiVHLQ----GHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHS 168

                          90       100
                  ....*....|....*....|....*...
gi 114187671  985 FSVGALAFSPDSQLLASGSFDSTAKLWD 1012
Cdd:PTZ00421  169 DQITSLEWNLDGSLLCTTSKDKKLNIID 196
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 751-815 2.11e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.49  E-value: 2.11e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114187671   751 TTTGSLR-QSLSGHSDW----------VRAIAFSSSGRLLASGSQDSTVKLWDAVTGAPLNDFCGHSGPICSVDFS 815
Cdd:pfam12894   14 TEDGELLlHRLNWQRVWtlspdkedleVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
Pgl COG2706
6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];
811-989 2.52e-04

6-phosphogluconolactonase, cycloisomerase 2 family [Carbohydrate transport and metabolism];


Pssm-ID: 442025 [Multi-domain]  Cd Length: 352  Bit Score: 44.90  E-value: 2.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  811 SVDFSPSGDLVVSgsVD------CTLRLwDVTTGSLKRTlngHTQPVQA------VAFSPNGEVL-VSGSQDKTIKLWA- 876
Cdd:COG2706   154 SVVFDPDGRFLYV--PDlgtdriYVYRL-DPATGKLPEP---PEVSLPPgsgprhLAFHPNGRFAyVINELDSTVSVYAy 227

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  877 -TTPGSLE--QTL----EGHSD--WVRAIAFSSCGR-LIASGSHDGTVRVWdagagAVKQAftvQGHLrnTVVGHQASVG 946
Cdd:COG2706   228 dAATGTLTliQTVstlpEDFTGenWAADIHISPDGRfLYVSNRGHNSIAVF-----AIDAD---GGKL--TLVGHVPTGG 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 114187671  947 A----VAFSPDGR-LLACGTHDSTISLWDI--TTGALrtTLAGHIFSVGA 989
Cdd:COG2706   298 KwprdFAIDPDGRfLLVANQKSDNITVFRIdaDTGKL--TPTGRSVPVPS 345
PTZ00420 PTZ00420
coronin; Provisional
 718-792 2.93e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 2.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  718 LEGHTGPIGAVAFSP-IDQVLATCSHDKTIKFW-----DTTTGSLRQS---LSGHSDWVRAIAFSSSGR-LLASGSQDST 787
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVWeiphnDESVKEIKDPqciLKGHKKKISIIDWNPMNYyIMCSSGFDSF 149


                  ....*
gi 114187671  788 VKLWD 792
Cdd:PTZ00420  150 VNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 788-875 7.44e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 7.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  788 VKLWDAVTGAPLNDFCGHSGPICSVDFSPS-GDLVVSGSVDCTLRLWDV--TTGSLKRT------LNGHTQPVQAVAFSP 858
Cdd:PTZ00420   56 IRLENQMRKPPVIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIphNDESVKEIkdpqciLKGHKKKISIIDWNP 135

                          90
                  ....*....|....*...
gi 114187671  859 -NGEVLVSGSQDKTIKLW 875
Cdd:PTZ00420  136 mNYYIMCSSGFDSFVNIW 153
PTZ00420 PTZ00420
coronin; Provisional
 844-918 1.78e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  844 LNGHTQPVQAVAFSP-NGEVLVSGSQDKTIKLWaTTPGSLEQT---------LEGHSDWVRAIAFSSCGRLI-ASGSHDG 912
Cdd:PTZ00420   70 LKGHTSSILDLQFNPcFSEILASGSEDLTIRVW-EIPHNDESVkeikdpqciLKGHKKKISIIDWNPMNYYImCSSGFDS 148


                  ....*.
gi 114187671  913 TVRVWD 918
Cdd:PTZ00420  149 FVNIWD 154
CysC COG0529
Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; ...
 181-209 4.58e-03

Adenylylsulfate kinase or related kinase [Inorganic ion transport and metabolism]; Adenylylsulfate kinase or related kinase is part of the Pathway/BioSystem: Cysteine biosynthesis


Pssm-ID: 440295 [Multi-domain]  Cd Length: 189  Bit Score: 39.69  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*....
gi 114187671  181 CIFWLNGMAGTGKSTISRTVAGRLKRQDR 209
Cdd:COG0529    17 FVVWFTGLSGSGKSTLANALERRLFERGR 45
PTZ00421 PTZ00421
coronin; Provisional
 1083-1178 4.91e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 4.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671 1083 VEFSP-DGRLLASGSNDGAIKLWDTYNGALQHT-------LDGHSGAIRAVAFSPGCQ-LLASGSTDNTVKVWNSADGTL 1153
Cdd:PTZ00421   81 VAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKA 160

                          90       100
                  ....*....|....*....|....*.
gi 114187671 1154 KQDLS-VKGVVTDMKFSIDGATLETS 1178
Cdd:PTZ00421  161 VEVIKcHSDQITSLEWNLDGSLLCTT 186
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 1034-1099 5.00e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 40.83  E-value: 5.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671  1034 HSGTVGIVAFSFDKKILASGSIDKTVKLWD-----------------------VITGSLLYTLEGHLDLIWAVEFSPDGR 1090
Cdd:pfam20426  123 HKDVVSCVAVTSDGSILATGSYDTTVMVWEvlrgrssekrsrntqtefprkdhVIAETPFHILCGHDDIITCLYVSVELD 202


                   ....*....
gi 114187671  1091 LLASGSNDG 1099
Cdd:pfam20426  203 IVISGSKDG 211
NACHT pfam05729
NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in ...
 184-338 8.71e-03

NACHT domain; This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription activation. This family is closely related to pfam00931.


Pssm-ID: 428606 [Multi-domain]  Cd Length: 166  Bit Score: 38.44  E-value: 8.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   184 WLNGMAGTGKSTISRTVA-----GRLKRQDRLAasFFFKRGE-QDRGNAKLLFSTIAKQLgssmpqlsldiqnaieddPD 257
Cdd:pfam05729    4 ILQGEAGSGKTTLLQKLAllwaqGKLPQGFDFV--FFLPCRElSRSGNARSLADLLFSQW------------------PE 63

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   258 ISDRVlREQFEKLILQPLSAakhcpntimVVVIDALDECDRTDD--------IQVILHLLPRVQQSTSMrlrFLITSRP- 328
Cdd:pfam05729   64 PAAPV-SEVWAVILELPERL---------LLILDGLDELVSDLGqldgpcpvLTLLSSLLRKKLLPGAS---LLLTVRPd 130

                          170
                   ....*....|.
gi 114187671   329 -VLPIKSGFER 338
Cdd:pfam05729  131 aLRDLRRGLEE 141
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 904-989 9.06e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.87  E-value: 9.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114187671   904 LIASGSHDGTV--------RVWDAGAGavkqaftvqghlrntvvGHQASVGAVAFSPDGRLLACGTHDSTISLWDITTGA 975
Cdd:pfam12894    9 LIALATEDGELllhrlnwqRVWTLSPD-----------------KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGK 71

                           90
                   ....*....|....
gi 114187671   976 LRttlagHIFSVGA 989
Cdd:pfam12894   72 IV-----HHFSAGS 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH