NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1140392527|gb|AQA28797|]
View 

RNA-dependent RNA polymerase [Lilac leaf chlorosis virus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
348-719 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


:

Pssm-ID: 438102  Cd Length: 332  Bit Score: 587.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 348 DIALELEKVTIDASVVRDWTKRGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMFEDEEARKIANRFINTV 427
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWTKPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 428 LDPNKLaqfpgyisegekgyfeqylvgksipedafidpcalvsmDKYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGK 507
Cdd:cd23252    81 IDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 508 VMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEF 587
Cdd:cd23252   123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 588 LDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLLDPNVTFVVASGDDSLIGSLKPLDRSN 667
Cdd:cd23252   203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140392527 668 EFLFTTLFNFEAKFPHNMPFVCSKFLCLVPTtsGGKKVVAVPNVLKLLIKLG 719
Cdd:cd23252   283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
348-719 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 587.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 348 DIALELEKVTIDASVVRDWTKRGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMFEDEEARKIANRFINTV 427
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWTKPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 428 LDPNKLaqfpgyisegekgyfeqylvgksipedafidpcalvsmDKYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGK 507
Cdd:cd23252    81 IDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 508 VMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEF 587
Cdd:cd23252   123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 588 LDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLLDPNVTFVVASGDDSLIGSLKPLDRSN 667
Cdd:cd23252   203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140392527 668 EFLFTTLFNFEAKFPHNMPFVCSKFLCLVPTtsGGKKVVAVPNVLKLLIKLG 719
Cdd:cd23252   283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
346-786 2.58e-154

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 458.26  E-value: 2.58e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 346 TSDIALELEKVTIDASVVRDWTK-RGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMFEDEEARKIANRFI 424
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKdKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 425 NTVLDPNKLAQFPGYISEGEK-GYFEQYLVGKSI--PEDAFIDPCALVSMDKYRHMIKTSLKPTEDNSIIFERPLPATIT 501
Cdd:pfam00978  81 KSFLDKEKLDKLDPIINTTENvSRWLDKQSGKKAaqLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 502 FHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKAL 581
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 582 GANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLldPNVTFVVASGDDSLIGSLK 661
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDL--EKIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 662 PlDRSNEFLFTTLFNFEAKFP-HNMPFVCSKFLCLVPTTsggkkVVAVPNVLKLLIKLGIKDM--NPFIFDAWYDSWLDL 738
Cdd:pfam00978 319 P-IEDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDGG-----AFFVPDPLKLLQKLGKKKIpdDEQHLDEIFTSLCDL 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1140392527 739 LWFFDNFFIVSEIRDYVSHRYLrRHTHFLEGAILALRTVFSSKTKCLK 786
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYY-KYAPEGYAALCALHKALSSFTLFFS 439
 
Name Accession Description Interval E-value
Bromoviridae_RdRp cd23252
RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense ...
348-719 0e+00

RNA-dependent RNA polymerase (RdRp) in the family Bromoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Bromoviridae, order Martellivirales. The Bromoviridae family of plant viruses contains tri-segmented, (+)ssRNA viruses with a total genome size of about 8 kb. There are six genera in this family: Alfamovirus, Anulavirus, Bromovirus, Cucumovirus, Ilarvirus, and Oleavirus. Bromoviridae virions are variable in morphology (spherical or bacilliform) and are transmitted mechanically, in/on the pollen and non-persistently by insect vectors. Members of the family cause major disease epidemics in fruit, vegetable and fodder crops such as tomato, cucurbits, bananas, and alfalfa. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438102  Cd Length: 332  Bit Score: 587.27  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 348 DIALELEKVTIDASVVRDWTKRGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMFEDEEARKIANRFINTV 427
Cdd:cd23252     1 DISLDVDHCRLDQSDFNDWTKPDGYLEPVLNTGSGSKRVGTQREALLAIKKRNANVPELGDSVDLDRVSNAVANRFLTTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 428 LDPNKLaqfpgyisegekgyfeqylvgksipedafidpcalvsmDKYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGK 507
Cdd:cd23252    81 IDVDRL--------------------------------------DKYMHMIKSDLKPVEDDSLHVERPVPATITYHKKGI 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 508 VMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEF 587
Cdd:cd23252   123 VMQFSPLFLAAFERLLRCLRSKIVIPSGKIHQLFMIDPSVLNASKHFKEIDFSKFDKSQGELHHEIQEHILNALGCPAPF 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 588 LDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLLDPNVTFVVASGDDSLIGSLKPLDRSN 667
Cdd:cd23252   203 TKWWFDFHRRSYISDRRAGVGFSVDFQRRTGDAFTYLGNTLVTLAELAYVYDLDDPNFDFVVASGDDSLIGSVEPLPRDD 282
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1140392527 668 EFLFTTLFNFEAKFPHNMPFVCSKFLCLVPTtsGGKKVVAVPNVLKLLIKLG 719
Cdd:cd23252   283 EDLFTTLFNFEAKFPHNQPFICSKFLLSDEF--GDENVFSVPDPLKLLQRLG 332
RdRP_2 pfam00978
RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The ...
346-786 2.58e-154

RNA dependent RNA polymerase; This family may represent an RNA dependent RNA polymerase. The family also contains the following proteins: 2A protein from bromoviruses putative RNA dependent RNA polymerase from tobamoviruses Non structural polyprotein from togaviruses


Pssm-ID: 395779  Cd Length: 440  Bit Score: 458.26  E-value: 2.58e-154
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 346 TSDIALELEKVTIDASVVRDWTK-RGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMFEDEEARKIANRFI 424
Cdd:pfam00978   1 TSDISLDLDDCRLDPSKSKPKPKdKEPYLVPVLRTAAPSPRQNTLKEVLLALKKRNFNVPELQESVDLDDTAERVAERFK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 425 NTVLDPNKLAQFPGYISEGEK-GYFEQYLVGKSI--PEDAFIDPCALVSMDKYRHMIKTSLKPTEDNSIIFERPLPATIT 501
Cdd:pfam00978  81 KSFLDKEKLDKLDPIINTTENvSRWLDKQSGKKAaqLKLDDLVPLHEVDLDRYKHMIKSDVKPKLDLSPQSERPALQTIT 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 502 FHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKAL 581
Cdd:pfam00978 161 YHDKGVTAYFSPIFRELFERLLYVLKPKIVFPTGMTSSLIAEHFEFLDASEDFLEIDFSKFDKSQGELHLLVQLEILKLL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 582 GANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLldPNVTFVVASGDDSLIGSLK 661
Cdd:pfam00978 241 GLDPELADLWFKFHRQSYIKDRKNGVGFSVDYQRKSGDANTYLGNTLVTMAMLASVYDL--EKIDCAAFSGDDSLIFSPK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 662 PlDRSNEFLFTTLFNFEAKFP-HNMPFVCSKFLCLVPTTsggkkVVAVPNVLKLLIKLGIKDM--NPFIFDAWYDSWLDL 738
Cdd:pfam00978 319 P-IEDPASRFATLFNMEAKVFdPSVPYFCSKFLLEVDGG-----AFFVPDPLKLLQKLGKKKIpdDEQHLDEIFTSLCDL 392
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 1140392527 739 LWFFDNFFIVSEIRDYVSHRYLrRHTHFLEGAILALRTVFSSKTKCLK 786
Cdd:pfam00978 393 TKSFNDDCVVLELLDLAVARYY-KYAPEGYAALCALHKALSSFTLFFS 439
Mayoviridae_RdRp cd23256
RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense ...
447-723 1.59e-66

RNA-dependent RNA polymerase (RdRp) in the family Mayoviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Mayoviridae, order Martellivirales. The Mayoviridae family consists of two genera, Idaeovirus and Pteridovirus. The genus Idaeovirus contains Raspberry bushy dwarf virus (RBDV), named after the host with which it was first associated (red raspberry, Rubus idaeu) and the disease which is characterized by bushiness (stunting and proliferation of canes); RBDV has recently been found causing an infection in grapevines. RBDV occurs in all tissues of the plant, including seed and pollen, and is transmitted in association with pollen, both vertically to the seed and horizontally to the pollinated plant; this is the only known method of natural spread of RBDV. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438106  Cd Length: 329  Bit Score: 224.62  E-value: 1.59e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 447 YFEQYL--VGKSIPEDAFIdpcALVSMDKYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGKVMSTSPIFLMMANRLML 524
Cdd:cd23256     9 QIQLYQnkVGNKVNDPVVL---ALTSLNKYSHMIKRDRKPVLTTAVQSEYTKAATITYHDKDITQVATPIFRQFKTRLLA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 525 CLNDKITIPSGKYHQL--YSIDPFSFEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRD 602
Cdd:cd23256    86 CKKSNLCIPLDHDHDIsgWLTNRHLGSENGTFTEIDFSKFDKSQGELHQLIQDLILLRFGCDPEFVSLWSTAHRSSSIKD 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 603 GLCGLGFSVAYQRRTGDACTYLGNTIITLAALAYLYDLLD-PNVTFVVASGDDSLIGSLKPLDRSNEfLFTTLFNFEAK- 680
Cdd:cd23256   166 QNVGISFKTDFQRRTGDAFTFLGNSLVTAVMLAYVLSFEDeKKIRYMLVGGDDSLICSYGPISVPLE-PLSTIFNMSCKl 244
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1140392527 681 FPHNMPFVCSKFLCLVpttsgGKKVVAVPNVLKLLIKLGIKDM 723
Cdd:cd23256   245 IQPSCPYFASRYIIRV-----GDEILCVPDPYKLLVKMGRKDI 282
Kitaviridae_RdRp cd23254
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of ...
474-723 3.02e-53

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Kitaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus leprosis virus C2 (genus Cilevirus); and Hibiscus green spot virus 2 (genus Higrevirus). Although related, there are considerable physical and genetic distinctions between members of the different genera. For example, cile- and higreviruses are associated with a bacilliform virion, whereas a spherical virion has been observed for the lone blunervirus for which microscopy has been reported. Moreover, the replication-associated polyproteins are encoded by a single genomic RNA for cile- and higreviruses, but are split between two genomic RNAs for blunerviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438104  Cd Length: 267  Bit Score: 185.81  E-value: 3.02e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 474 YRHMIKTSLKPTEDNSIIFERPLPATITFHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYS------IDPFS 547
Cdd:cd23254     3 YSFMIKRNPKPNLTVDAAYKYPALQTIAYHDKDINAIFCPIFRELKKRLLAVLKPNFVIFTDMSPEDFEellnrrFPPEV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 548 FEMTKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNT 627
Cdd:cd23254    83 LSKLLHKLEIDISKYDKSQGELALLFECKLMRRFGVPEELVELWFNAHVLTTLYDRTNKLKALVEYQRKSGDASTFFGNT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 628 IITLAALAYLYDLLDpnVTFVVASGDDSLIGSLKPLDRSNEFLFTTLFNFEAKFPH-NMPFVCSKFLCLVPTtsggkKVV 706
Cdd:cd23254   163 LFLMAVLADLFDLSD--LELALFSGDDSLLFGRNLLDYDDSQHFALKFNLESKFLNyKYPYFCSKFLLPVGG-----RWY 235
                         250
                  ....*....|....*..
gi 1140392527 707 AVPNVLKLLIKLGIKDM 723
Cdd:cd23254   236 FVPDPVKLLTKLGRHDL 252
Virgaviridae_RdRp cd23251
RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense ...
332-722 1.18e-46

RNA-dependent RNA polymerase (RdRp) in the family Virgaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Virgaviridae, order Martellivirales. The Virgaviridae is a family of plant viruses with rod-shaped virions, a (+)ssRNA genome with a 3'-terminal tRNA-like structure and a replication protein similar to those of the alpha-like supergroup. Plants serve as natural hosts. The name of the family is derived from the Latin word virga (rod), as all viruses in this family are rod-shaped. There are currently 59 species in this family, divided among seven genera: Goravirus, Furovirus, Hordeivirus, Pecluvirus, Pomovirus, Tobamovirus, and Tobravirus. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438101  Cd Length: 427  Bit Score: 172.42  E-value: 1.18e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 332 DLDGRErffqeiVETSDIALELEKVTIDASVVRDWTKRGAVLSSKFNTGAMSRRNPTFREAALAVKKRNLNVPDLKQVMF 411
Cdd:cd23251    10 DFDGYT------VATSDINLNVEDCTLDPSKSVKVWQEKEGLKPVLRTAMPEKRQNGLLESLLALIKRNMAAPKLQGAVN 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 412 EDEEARKIANRFINTVLDPNKLAQFPGYISEGEKGYFEQYLV---GKSIPEDAFIDpcaLVSMDKYRHMIKTSLKPTEDN 488
Cdd:cd23251    84 EFETIERVIKKAKDVFFDEDLIDRSPLSTRESFLRWWDKQSTtarAQLLADDRVLD---EIDVCTYNFMIKNDVKPKLDL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 489 SIIFERPLPATITFHDK------GKVMSTspiflmmanrlmlcLNDKItipsgkyhqLYSIDP---FSFEMTKE------ 553
Cdd:cd23251   161 SPQSEYAALQTVVYPDKivnalfGPIFKE--------------INERI---------LSALDPhvvFNTRMTAEelnetv 217
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 554 ----------FKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTY 623
Cdd:cd23251   218 efldpdeeydALEIDFSKFDKSKTSLHIRAVIELYKLFGLDGMLAFLWEKSQCQTTVKDRQNGIKAYLLYQQKSGNCDTY 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 624 LGNTIITLAALAYLYDLLDpnVTFVVASGDDSLIGSLK------PLDRSNeflftTLFNFEAK-FPHNMPFVCSKFLCLV 696
Cdd:cd23251   298 GSNTWSAALALLSMLPLEK--AIFMIFGGDDSLILFPKglvipdPCRRLA-----SLWNFECKlFKFKYGYFCGKFLLKH 370
                         410       420
                  ....*....|....*....|....*.
gi 1140392527 697 pttsgGKKVVAVPNVLKLLIKLGIKD 722
Cdd:cd23251   371 -----GDGYIFYPDPLKLITKLGRKD 391
Closteroviridae_RdRp cd23253
RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense ...
473-719 3.09e-46

RNA-dependent RNA polymerase (RdRp) in the family Closteroviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the RdRp of RNA viruses belonging to the family Closteroviridae, order Martellivirales. Viruses in the family Closteroviridae have a mono-, bi- or tripartite (+)ssRNA genome of 13-19 kb, and non-enveloped, filamentous particles 650-2200 nm long and 12 nm in diameter. They infect plants, mainly dicots, many of which are fruit crops. Members of the family are classified into four genera: Ampelovirus, Closterovirus, Crinivirus and Velarivirus. Their genetic diversity is primarily influenced by strong negative selection and recombination. Closteroviridae viruses are mostly phloem-restricted and induce specific cytoplasmic aggregates of virus particles intermingled with membranous vesicles derived from the endoplasmic reticulum and possibly mitochondria. Their transmission is by aphids, whiteflies, pseudococcid mealybugs or soft scale insects in a semi-persistent manner. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438103  Cd Length: 266  Bit Score: 166.20  E-value: 3.09e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 473 KYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGkyhqlYSIDPFSfEMTK 552
Cdd:cd23253     2 SFKLMVKGDMKPKLDSSSLSKYPPGQNIVYHERAINAFFSPIFLEVFDRIKYCLSDKIILYSG-----MNLEELA-SLIR 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 553 E----------FKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACT 622
Cdd:cd23253    76 SklgdpldeykTVEIDFSKFDKSQGVLFKVYEELVYKFFGFSEELYDNWKCSEYFSCRATSDSGVSLELGAQRRTGSPNT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 623 YLGNTIITLAALAYLYDLLDPNvtFVVASGDDSLIGSLKPLDrSNEFLFTTLFNFEAKFPHN-MPFVCSKFlcLVPTtsg 701
Cdd:cd23253   156 WLGNTLVTLGILSSSYDLDDID--LLLVSGDDSLIFSKKPLP-NKANEINLDFGFEAKFIENsVPYFCSKF--IIED--- 227
                         250
                  ....*....|....*...
gi 1140392527 702 GKKVVAVPNVLKLLIKLG 719
Cdd:cd23253   228 RGKIKVVPDPVKLFEKLS 245
ps-ssRNAv_Martellivirales_RdRp cd23208
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of ...
472-657 1.43e-44

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Martellivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Martellivirales, class Alsuviricetes. The order Martellivirales consists of seven families: Bromoviridae, Closteroviridae, Endornaviridae, Kitaviridae, Mayoviridae, Togaviridae, and Virgaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438058 [Multi-domain]  Cd Length: 190  Bit Score: 159.07  E-value: 1.43e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 472 DKYRHMIKTSLKPTEDNSIIFERPLPATITFHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSIDPFSFEMT 551
Cdd:cd23208     1 DKYEMMIKSDVKPKLDLTAQQEYPKLQTIVYHDKNITAIFCPIFKELFERLLSCLKKKVVIYTGMMTSAELNDFISALHL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 552 KEFK---EIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRRTGDACTYLGNTI 628
Cdd:cd23208    81 ESGYyvlEIDFSKFDKSQGALHLLTELLILRRLGVDEPLLVLWEFAHTQSTTRDINNGISFETAYQRKSGDAFTYFGNTL 160
                         170       180
                  ....*....|....*....|....*....
gi 1140392527 629 ITLAALAYLYDLLDPNvtFVVASGDDSLI 657
Cdd:cd23208   161 VTMAALLDVLDLEKIV--CIAFGGDDSLI 187
ps-ssRNAv_Alsuviricetes_RdRp cd23182
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of ...
474-657 9.13e-19

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the class Alsuviricetes of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the class Alsuviricetes, phylum: Kitrinoviricota. Alsuviricetes is a class of [(+)ssRNA] viruses which infect eukaryotes. The name of the group is a syllabic abbreviation of "alpha supergroup" with the suffix -viricetes indicating a virus class. The class Alsuviricetes includes three orders: Hepelivirales, Martellivirales, and Tymovirales. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438032 [Multi-domain]  Cd Length: 187  Bit Score: 84.96  E-value: 9.13e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 474 YRHMIKTSLKPTeDNSIIFERPLPATITFHDKGKVMSTSPIFLMMANRLMLCLNDKITI---PSGKYHQLYS--IDPFSF 548
Cdd:cd23182     3 IDFLIKTQQKVS-PKTPFNTGKAGQTIAAHSKSINFVLGPWIRYLEERLRDGSRTHRYSnglMDEEEAMLSQwkINHVPH 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 549 emtKEFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFGSHEISHIRD-GLCGLGfSVAYQRRTGDACTYLGNT 627
Cdd:cd23182    82 ---ATFVSNDYTAFDKSHNGESLLLEAAIMRRIGTPAAAPNLFIELHGKRTLRAkVLGGSG-ELDGMRDSGAAWTYCRNT 157
                         170       180       190
                  ....*....|....*....|....*....|
gi 1140392527 628 IITLAALAYLYDLldpNVTFVVASGDDSLI 657
Cdd:cd23182   158 DYNLAVMLSLYRL---KVKPAAFSGDDSLL 184
Endornaviridae_RdRp cd23255
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of ...
500-685 6.10e-14

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the family Endornaviridae of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Endornaviridae, order Martellivirales. The family Endornaviridae includes viruses with linear (+)ssRNA genomes that range from 9.7 to 17.6 kb. The family consists of two genera, Alphaendornavirus and Betaendornavirus. Alphaendornavirus includes species whose members infect plants, fungi and oomycetes, while the genus Betaendornavirus includes species whose members infect ascomycete fungi. Plant endornaviruses are transmitted only through the gametes. A conserved RNA-dependent RNA polymerase domain located in the C-terminal region of the polyprotein is a feature common to all endornaviruses. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438105  Cd Length: 237  Bit Score: 72.18  E-value: 6.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 500 ITFHDKGKVMSTSPIFLMMANRLMLCLNDKItipsgkyhqLYS--IDPF-------SFEMTKEFKEIDFSKFDKsqQRLH 570
Cdd:cd23255    61 IVWQRKGICAIFSPIFNEAKKRLKSLLKPKV---------VYAdgLTPDelsarlrLVKNVKYFFEDDLSKQDR--QTDK 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 571 HLIQ--YHVFKALGANTEFLDMW--------FGSHEISHIRDGlcglgfsvayQRRTGDACTYLGNTIITLAALAYLYDL 640
Cdd:cd23255   130 PIIDveMELYKLLGVDPNVIELWrevhenwrFKGKGVRGVGDA----------MRLTGQATTALGNVITNLLVHSRLVKR 199
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1140392527 641 LDPNVTFVVASGDDSLIGSLKPLDrsneflfTTLFNFEAKFPHNM 685
Cdd:cd23255   200 NGSNLKLMLVLGDDNLILTDTKID-------LENLRKEIAEYHNM 237
ps-ssRNAv_Hepelivirales_RdRp cd23209
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of ...
473-657 4.85e-05

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Hepelivirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Hepelivirales, class Alsuviricetes. This Hepelivirales order consists of four families: Alphatetraviridae, Benyviridae, Hepeviridae, and Matonaviridae. The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438059 [Multi-domain]  Cd Length: 183  Bit Score: 44.79  E-value: 4.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 473 KYRHMIKTSLKPTEDNSIIFERPlPATITFHDKGKVMSTSPIFLMMANRLMLCLNDKITIPSGKYHQLYSiDPFSFEMTK 552
Cdd:cd23209     2 KITFFQKDCRKFTDCEPVAHGKA-GQGISAWSKELCFVFGPWFRALEKILRRALKPNVLYANGHEAEPFV-DKINQAHSA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 553 EFKEIDFSKFDKSQQRLHHLIQYHVFKALGANTEFLDMWFG--SHEISHIRDGlcglGFSVAYQRRTGDACTYLGNTIIT 630
Cdd:cd23209    80 VFIENDFTEFDSTQNLFSLLVELEILEACGMPPALAELYRAlrAKWTLQAREG----SLEGTCKKTSGEPGTLLHNTIWN 155
                         170       180
                  ....*....|....*....|....*..
gi 1140392527 631 LAALAYLYDLLDPnvTFVVASGDDSLI 657
Cdd:cd23209   156 MAVMMHMVRGGVR--KAAAFKGDDSVV 180
RNA_dep_RNAP cd01699
RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the ...
556-657 4.64e-03

RNA_dep_RNAP: RNA-dependent RNA polymerase (RdRp) is an essential protein encoded in the genomes of all RNA containing viruses with no DNA stage. RdRp catalyzes synthesis of the RNA strand complementary to a given RNA template. RdRps of many viruses are products of processing of polyproteins. Some RdRps consist of one polypeptide chain, and others are complexes of several subunits. The domain organization and the 3D structure of the catalytic center of a wide range of RdRps, including those with a low overall sequence homology, are conserved. The catalytic center is formed by several motifs containing a number of conserved amino acid residues. This subfamily represents the RNA-dependent RNA polymerases from all positive-strand RNA eukaryotic viruses with no DNA stage.


Pssm-ID: 238843 [Multi-domain]  Cd Length: 278  Bit Score: 39.96  E-value: 4.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 556 EIDFSKFDKSQQRLhhlIQYHVFKALGANTEFLDMWFGSHEISHIRDGLCGLGFSVAYQRR----TGDACTYLGNTIITL 631
Cdd:cd01699   100 ALDYSRFDSSLSPQ---LLEAEHSIYNALYDDDDELERRNLLRSLTNNSLHIGFNEVYKVRggrpSGDPLTSIGNSIINC 176
                          90       100       110
                  ....*....|....*....|....*....|
gi 1140392527 632 AALAYLYDLLDPNVTFVVAS----GDDSLI 657
Cdd:cd01699   177 ILVRYAFRKLGGKSFFKNVRllnyGDDCLL 206
ps-ssRNA_RdRp_Tymovirales cd23207
catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of ...
558-657 7.36e-03

catalytic core domain of RNA-dependent RNA polymerase (RdRp) in the order Tymovirales of positive-sense single-stranded RNA [(+)ssRNA] viruses; This group contains the catalytic core domain of RdRp of RNA viruses belonging to the order Tymovirales. The Tymovirales order contains viruses that mostly infect plants, have a single molecule of (+)ssRNA, and which are united by the similarities in their replication-associated polyproteins. Tymovirales contains five families (Alpha-, Beta-, Delta- and Gammaflexiviridae and Tymoviridae) and groups mostly plant-infecting agents, although a few Tymovirales members have either fungal or insect hosts. Botrytis virus F (BVF), isolated from the fungus Botrytis cinerea, is a flexuous mycovirus that is typical of members of the genus Mycoflexivirus (family Gammaflexiviridae). The RdRp domain displays a right hand with three functional subdomains, called fingers, palm, and thumb. All RdRps contain conserved polymerase motifs (A-G), located in the palm (A-E motifs) and finger (F-G) subdomains. All these motifs have been implicated in RdRp fidelity such as processes of correct incorporation and reorganization of nucleotides.


Pssm-ID: 438057 [Multi-domain]  Cd Length: 188  Bit Score: 38.54  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1140392527 558 DFSKFDKSQ------------QRLH---HLIQYHVFKALGANTEFldmwfGSHEIshirdglcglgfsvayQRRTGDACT 622
Cdd:cd23207    94 DYTAFDQSQdgefvvfevllmRHLHipdDLIELYVDIKTNAYSHL-----GPLSI----------------MRLTGEPGT 152
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1140392527 623 YLGNTIITLAALAYLYDLldPNVTFVVASGDDSLI 657
Cdd:cd23207   153 FDFNTDYNLALTYAKYDL--PPGTPICFSGDDSVA 185
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH