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Conserved domains on  [gi|113965|sp|P24639|]
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RecName: Full=Annexin A7; AltName: Full=Annexin VII; AltName: Full=Annexin-7; AltName: Full=Synexin

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 165-230 5.85e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.94  E-value: 5.85e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     165 HDAEVLRKAMKGIGTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVAL 230
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 237-302 3.54e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 3.54e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     237 FDVEQIHSACAGAGTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLLEKL 302
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 396-460 6.00e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 6.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     396 YFAEILNKSMKGAGTNDNKLIRTVVTQMHN-MPQIKTAYSTLFKNSLAHDIQADCSGDFKKLLLDI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAqLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-386 1.55e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 1.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113965     320 DAEdLYKAGEGKIGTDEKEFIKILTSRSLPHIAAVASEYIKHHKKhSLIKAIDSEFSGSIKTGLIAI 386
Cdd:pfam00191   2 DAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK-DLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 165-230 5.85e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.94  E-value: 5.85e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     165 HDAEVLRKAMKGIGTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVAL 230
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 237-302 3.54e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 3.54e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     237 FDVEQIHSACAGAGTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLLEKL 302
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
178-230 3.91e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.61  E-value: 3.91e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 113965      178 GTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVAL 230
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 396-460 6.00e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 6.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     396 YFAEILNKSMKGAGTNDNKLIRTVVTQMHN-MPQIKTAYSTLFKNSLAHDIQADCSGDFKKLLLDI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAqLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
250-299 1.45e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 1.45e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 113965      250 GTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLL 299
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-386 1.55e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 1.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113965     320 DAEdLYKAGEGKIGTDEKEFIKILTSRSLPHIAAVASEYIKHHKKhSLIKAIDSEFSGSIKTGLIAI 386
Cdd:pfam00191   2 DAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK-DLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
333-386 3.63e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 63.58  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113965      333 GTDEKEFIKILTSRSLPHIAAVASEYIKHHKKhSLIKAIDSEFSGSIKTGLIAI 386
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGK-DLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
409-458 3.65e-10

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 55.11  E-value: 3.65e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113965      409 GTNDNKLIRTVVT----QMHnmpQIKTAYSTLFKNSLAHDIQADCSGDFKKLLL 458
Cdd:smart00335   1 GTDEKTLIEILASrsnaQLQ---AIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 165-230 5.85e-27

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 102.94  E-value: 5.85e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     165 HDAEVLRKAMKGIGTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVAL 230
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 237-302 3.54e-22

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 3.54e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     237 FDVEQIHSACAGAGTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLLEKL 302
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
178-230 3.91e-20

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 83.61  E-value: 3.91e-20
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 113965      178 GTNESDLIKVLANRNWAEREQIKREFSAKYSKDLIQDIKSETSGNFEKCLVAL 230
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 396-460 6.00e-19

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 80.60  E-value: 6.00e-19
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113965     396 YFAEILNKSMKGAGTNDNKLIRTVVTQMHN-MPQIKTAYSTLFKNSLAHDIQADCSGDFKKLLLDI 460
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAqLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
250-299 1.45e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 1.45e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 113965      250 GTNENTIIEILVTRSNVQMEYIKQIFKNKHGKSLKDRLESEASGDFKKLL 299
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLL 50
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 320-386 1.55e-16

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 73.66  E-value: 1.55e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113965     320 DAEdLYKAGEGKIGTDEKEFIKILTSRSLPHIAAVASEYIKHHKKhSLIKAIDSEFSGSIKTGLIAI 386
Cdd:pfam00191   2 DAE-LLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGK-DLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
333-386 3.63e-13

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 63.58  E-value: 3.63e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113965      333 GTDEKEFIKILTSRSLPHIAAVASEYIKHHKKhSLIKAIDSEFSGSIKTGLIAI 386
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGK-DLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
409-458 3.65e-10

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 55.11  E-value: 3.65e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 113965      409 GTNDNKLIRTVVT----QMHnmpQIKTAYSTLFKNSLAHDIQADCSGDFKKLLL 458
Cdd:smart00335   1 GTDEKTLIEILASrsnaQLQ---AIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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