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Conserved domains on  [gi|113930726|ref|NP_033013|]
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pentraxin-related protein PTX3 precursor [Mus musculus]

Protein Classification

PTX domain-containing protein( domain architecture ID 10639996)

PTX domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
175-381 1.47e-89

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


:

Pssm-ID: 128463  Cd Length: 206  Bit Score: 268.37  E-value: 1.47e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   175 LPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQS-LVLVVGGKe 253
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGYSLFSYATKGQDNELLLYKEKQGeYSLYIGGK- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   254 nKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTvEMAKSHSVPEGGLLQIGQEKNgcCVGGGFDESLAFSGRI 333
Cdd:smart00159  80 -KVQFPVPESDGKWHHICTTWESSSGIAELWVDGKPGVRK-GLAKGYTVKPGGSIILGQEQD--SYGGGFDATQSFVGEI 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 113930726   334 TGFNIWDRVLSEEEIRASGGVESCHIrGNVVGWGVTEIQAHGGAQYVS 381
Cdd:smart00159 156 GDLNMWDSVLSPEEIKSVYKGSTFSI-GNILNWRALNYEVHGGVVIKP 202
 
Name Accession Description Interval E-value
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
175-381 1.47e-89

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 268.37  E-value: 1.47e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   175 LPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQS-LVLVVGGKe 253
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGYSLFSYATKGQDNELLLYKEKQGeYSLYIGGK- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   254 nKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTvEMAKSHSVPEGGLLQIGQEKNgcCVGGGFDESLAFSGRI 333
Cdd:smart00159  80 -KVQFPVPESDGKWHHICTTWESSSGIAELWVDGKPGVRK-GLAKGYTVKPGGSIILGQEQD--SYGGGFDATQSFVGEI 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 113930726   334 TGFNIWDRVLSEEEIRASGGVESCHIrGNVVGWGVTEIQAHGGAQYVS 381
Cdd:smart00159 156 GDLNMWDSVLSPEEIKSVYKGSTFSI-GNILNWRALNYEVHGGVVIKP 202
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
179-380 8.92e-73

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 225.23  E-value: 8.92e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726 179 CETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLS-SQSLVLVVGGKENKLA 257
Cdd:cd00152    5 SGKVFVFPKESDTSYVKLKPELPKPLQAFTLCLWVYTDLSTREYSLFSYATKGQDNELLLYKEkDGGYSLYIGGKEVTFK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726 258 ADTvvSLGRWSHLCGTWSSEQGSMSLWANGELVATTVeMAKSHSVPEGGLLQIGQEKNGCcvGGGFDESLAFSGRITGFN 337
Cdd:cd00152   85 VPE--SDGAWHHICVTWESTSGIAELWVNGKLSVRKS-LKKGYTVGPGGSIILGQEQDSY--GGGFDATQSFVGEISDVN 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 113930726 338 IWDRVLSEEEIRASgGVESCHIRGNVVGWGVTEIQAHGGAQYV 380
Cdd:cd00152  160 MWDSVLSPEEIKNV-YSEGGTLSGNILNWRALNYEINGGVVIK 201
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
185-377 9.04e-23

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 94.41  E-value: 9.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726  185 FPMRSKKIFGSVHPVRPMKLESFSTCIWVKaTDVLNKTILFSYGTKWNPYEIQLYLSSQ-SLVLVVGGKEN-KLAADTVV 262
Cdd:pfam00354   5 FPKESDTSYVSLIPELEKPLQNFTLCLRFY-TDLSRSYSLFSYATKKQDNELLIFKEKDgEYSFYVGGAEVlFKVSEIPV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726  263 SlgrWSHLCGTWSSEQGSMSLWANGELVATTVeMAKSHSVPEGGLLQIGQEKNGccVGGGFDESLAFSGRITGFNIWDRV 342
Cdd:pfam00354  84 A---PVHICTSWESSSGIAEFWVDGKPWVRKS-LKKGYTVGAPPSIILGQEQDS--YGGGFDASQSLVGEIGDLNMWDYV 157
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 113930726  343 LSEEEIRASggVESCHIRGNVVGWGVTEIQAHGGA 377
Cdd:pfam00354 158 LTPEEINTV--YKGGPFSPNILDWRALNYEARGYV 190
 
Name Accession Description Interval E-value
PTX smart00159
Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric ...
175-381 1.47e-89

Pentraxin / C-reactive protein / pentaxin family; This family form a doscoid pentameric structure. Human serum amyloid P demonstrates calcium-mediated ligand-binding.


Pssm-ID: 128463  Cd Length: 206  Bit Score: 268.37  E-value: 1.47e-89
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   175 LPAGCETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLSSQS-LVLVVGGKe 253
Cdd:smart00159   1 QTDLTGKVFVFPKESDTSYVKLKPELPKPLQAFTVCLWFYSDLSPRGYSLFSYATKGQDNELLLYKEKQGeYSLYIGGK- 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   254 nKLAADTVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTvEMAKSHSVPEGGLLQIGQEKNgcCVGGGFDESLAFSGRI 333
Cdd:smart00159  80 -KVQFPVPESDGKWHHICTTWESSSGIAELWVDGKPGVRK-GLAKGYTVKPGGSIILGQEQD--SYGGGFDATQSFVGEI 155
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 113930726   334 TGFNIWDRVLSEEEIRASGGVESCHIrGNVVGWGVTEIQAHGGAQYVS 381
Cdd:smart00159 156 GDLNMWDSVLSPEEIKSVYKGSTFSI-GNILNWRALNYEVHGGVVIKP 202
PTX cd00152
Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their ...
179-380 8.92e-73

Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated in innate immunity. CRP binds to ligands containing phosphocholine, SAP binds to amyloid fibrils, DNA, chromatin, fibronectin, C4-binding proteins and glycosaminoglycans. "Long" pentraxins have N-terminal extensions to the common pentraxin domain; one group, the neuronal pentraxins, may be involved in synapse formation and remodeling, and they may also be able to form heteromultimers.


Pssm-ID: 238086  Cd Length: 201  Bit Score: 225.23  E-value: 8.92e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726 179 CETAIFFPMRSKKIFGSVHPVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYLS-SQSLVLVVGGKENKLA 257
Cdd:cd00152    5 SGKVFVFPKESDTSYVKLKPELPKPLQAFTLCLWVYTDLSTREYSLFSYATKGQDNELLLYKEkDGGYSLYIGGKEVTFK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726 258 ADTvvSLGRWSHLCGTWSSEQGSMSLWANGELVATTVeMAKSHSVPEGGLLQIGQEKNGCcvGGGFDESLAFSGRITGFN 337
Cdd:cd00152   85 VPE--SDGAWHHICVTWESTSGIAELWVNGKLSVRKS-LKKGYTVGPGGSIILGQEQDSY--GGGFDATQSFVGEISDVN 159
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 113930726 338 IWDRVLSEEEIRASgGVESCHIRGNVVGWGVTEIQAHGGAQYV 380
Cdd:cd00152  160 MWDSVLSPEEIKNV-YSEGGTLSGNILNWRALNYEINGGVVIK 201
Pentaxin pfam00354
Pentaxin family; Pentaxins are also known as pentraxins.
185-377 9.04e-23

Pentaxin family; Pentaxins are also known as pentraxins.


Pssm-ID: 278768  Cd Length: 194  Bit Score: 94.41  E-value: 9.04e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726  185 FPMRSKKIFGSVHPVRPMKLESFSTCIWVKaTDVLNKTILFSYGTKWNPYEIQLYLSSQ-SLVLVVGGKEN-KLAADTVV 262
Cdd:pfam00354   5 FPKESDTSYVSLIPELEKPLQNFTLCLRFY-TDLSRSYSLFSYATKKQDNELLIFKEKDgEYSFYVGGAEVlFKVSEIPV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726  263 SlgrWSHLCGTWSSEQGSMSLWANGELVATTVeMAKSHSVPEGGLLQIGQEKNGccVGGGFDESLAFSGRITGFNIWDRV 342
Cdd:pfam00354  84 A---PVHICTSWESSSGIAEFWVDGKPWVRKS-LKKGYTVGAPPSIILGQEQDS--YGGGFDASQSLVGEIGDLNMWDYV 157
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 113930726  343 LSEEEIRASggVESCHIRGNVVGWGVTEIQAHGGA 377
Cdd:pfam00354 158 LTPEEINTV--YKGGPFSPNILDWRALNYEARGYV 190
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
198-349 2.96e-19

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 83.59  E-value: 2.96e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726  198 PVRPMKLESFSTCIWVKATDVLNKTILFSYGTKWNPYEIQLYlSSQSLVLVVGGKENK---LAADTVVSLGRWSHLCGTW 274
Cdd:pfam13385  10 PDALLPTSDFTVSAWVKPDSLPGWARAIISSSGGGGYSLGLD-GDGRLRFAVNGGNGGwdtVTSGASVPLGQWTHVAVTY 88
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 113930726  275 SSeqGSMSLWANGELVATTVEMAKSHSVPeGGLLQIGQEKNGccvgggfdeSLAFSGRITGFNIWDRVLSEEEIR 349
Cdd:pfam13385  89 DG--GTLRLYVNGVLVGSSTLTGGPPPGT-GGPLYIGRSPGG---------DDYFNGLIDEVRIYDRALSAAEIA 151
LamGL smart00560
LamG-like jellyroll fold domain;
260-344 7.08e-06

LamG-like jellyroll fold domain;


Pssm-ID: 214722 [Multi-domain]  Cd Length: 133  Bit Score: 45.10  E-value: 7.08e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726   260 TVVSLGRWSHLCGTWSSEQGSMSLWANGELVATTVEMAKSHSvpeGGLLQIGQEKNGccvGGGFDEslaFSGRITGFNIW 339
Cdd:smart00560  56 TADWIGVWVHLAGVYDGGAGKLSLYVNGVEVATSETQPSPSS---GNLPQGGRILLG---GAGGEN---FSGRLDEVRVY 126

                   ....*
gi 113930726   340 DRVLS 344
Cdd:smart00560 127 NRALT 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
223-311 1.34e-04

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 41.63  E-value: 1.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113930726 223 ILFSYGTKWNPYEIQLYLSSQSLVLVV--GGKENKLAADTVVSLGRWSHLCGTWssEQGSMSLWANGELVATTVEMAKSH 300
Cdd:cd00110   36 LLLYAGSQNGGDFLALELEDGRLVLRYdlGSGSLVLSSKTPLNDGQWHSVSVER--NGRSVTLSVDGERVVESGSPGGSA 113
                         90
                 ....*....|.
gi 113930726 301 SVPEGGLLQIG 311
Cdd:cd00110  114 LLNLDGPLYLG 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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