|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
13-446 |
3.00e-90 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 280.34 E-value: 3.00e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 13 RTLHLTWFAFFLTFVVWFNLAPLAT-TVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIP 91
Cdd:TIGR00886 1 RNLFFSWFGFFLSFLVWFAFSPLAVfLIKDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 92 CLMFASA-QDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGwlsfSGGFE 170
Cdd:TIGR00886 81 CLWAGLAvQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAQFVMPPIIG----SLIFG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 171 LPSGAVLNWRGAIAL-TGIISAVYGFIYYFNVSDTPPGKtyqkpertaglevtsmrdfwgllgmnvpfaailcvlcwrlq 249
Cdd:TIGR00886 157 GGQPAHLAWGWAFVIvPAGILLLPALLIFFVGADTPPGK----------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 250 kvgflnagtyplalgavliwfifqtwgiirtNRELIMGTKTYpkEDRYEFKQVAILELTYIVNFGSELAVVSMLPTFFET 329
Cdd:TIGR00886 196 -------------------------------PATGKLSFKEA--LKVFGNRHTWILALLYSVTFGSFLGVSSIFAMLFKD 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 330 TFDLPKATAGILASCFAFVNLVARPAGGLISDKLGS-RKNTMAFLTGGLGIGYLVMSMIKPGTFSGttgiiiAVLITMLA 408
Cdd:TIGR00886 243 QFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGaRKLLMNFLGVAMGAFLVVLGLVSDGSLAA------FIVLFVAL 316
|
410 420 430
....*....|....*....|....*....|....*...
gi 113882946 409 SFFVQSGEGATFALVPLVKRRVTGQVAGLVGAYGNVGA 446
Cdd:TIGR00886 317 FFFAGAGNGSTFALVPHIFRRATGAVSGLIGAIGNLGG 354
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
15-497 |
3.30e-78 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 250.25 E-value: 3.30e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 15 LHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLM 94
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 95 FASA-QDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSFSGGFelps 173
Cdd:cd17341 81 LALAvSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGF---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 174 gavLNWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERtaglevtsmrdfwgllgmnvpfaailcvlcwrlqkvgf 253
Cdd:cd17341 157 ---VGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFL-------------------------------------- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 254 lnagtyplalgavliwfifqtwgiirtnrelimgtktYPKEDRYEFKQVAILELTYIVNFGSELAVVSMLPTFFETTFDL 333
Cdd:cd17341 196 -------------------------------------KVQLAVLKNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGL 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 334 PKATAGILASCFAFVNLVARPAGGLISDKLGSRKNTMA-FLTGGLGIGYLVMSMIKPGtfsgtTGIIIAVLITMLASFFV 412
Cdd:cd17341 239 PLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWlFIVMTIGAALLSLSLPTSG-----TNLVLFLALFVALGLGA 313
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 413 QSGEGATFALVPLVKRRVTGQVAGLVGAYGNVGAVTYLTIFSLLPMWMGggkdpspeiiaasnSAFFQVLGVAGLIVAFF 492
Cdd:cd17341 314 GAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTG--------------SGVGAFSLFGVLAVACT 379
|
....*
gi 113882946 493 CFFFL 497
Cdd:cd17341 380 LLVWL 384
|
|
| PLN00028 |
PLN00028 |
nitrate transmembrane transporter; Provisional |
5-453 |
6.01e-53 |
|
nitrate transmembrane transporter; Provisional
Pssm-ID: 177665 [Multi-domain] Cd Length: 476 Bit Score: 186.29 E-value: 6.01e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 5 LWSF-QGRYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSS 83
Cdd:PLN00028 27 LFSFaRPHMRAFHLSWISFFTCFVSTFAAAPLLPIIRDNLNLTKSDIGNAGIASVSGSIFSRLAMGPVCDLYGPRYGSAF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 84 LLVFSVIPCLMFASAQDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLagwl 163
Cdd:PLN00028 107 LLMLTAPAVFCMSLVSSATGFIAVRFFIGFSLATFVSCQYWMSTMFNGKIVGTANGIAAGWGNLGGGVTQLLMPLV---- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 164 sFSGGFELPSGAVLNWRGAIALTGIISAVYGFIYYFNVSDTPPGKtYQKPERTAGLEVTSMrdfwgllgmnvpfaailcv 243
Cdd:PLN00028 183 -FPLIKDAGAPSFTAWRIAFFVPGLLHIIMGILVLTLGQDLPDGN-YRELKKSGTMPKDSF------------------- 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 244 lcWRLQKVGFLNagtyplalgavliwfiFQTWgiirtnrelimgtktypkedryefkqvaILELTYIVNFGSELAVVSML 323
Cdd:PLN00028 242 --SKVLRYGVTN----------------YRTW----------------------------ILALTYGYSFGVELTMDNII 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 324 PTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRkntmaF-LTGGLGIGYLVMSM--IKPGTFSGTTGIII 400
Cdd:PLN00028 276 AEYFYDRFGLSLETAGAIAASFGLMNLFARPAGGYLSDVAARR-----FgMRGRLWALWIVQTLggVFCIWLGRANSLGA 350
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 113882946 401 AVLITMLASFFVQSGEGATFALVPLVKRRVTGQVAGLVGAYGNVGAVTYLTIF 453
Cdd:PLN00028 351 AIVVMILFSIFVQAACGATFGIVPFVSRRSLGVISGLTGAGGNVGAVLTQLLF 403
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-502 |
7.29e-51 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 178.54 E-value: 7.29e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 10 GRYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSV 89
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 90 IPCLMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSfsgg 168
Cdd:COG2223 82 IGLLLLALAVSYWLLLLLGLLLGIgGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG---- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 169 felpsgavlnWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAG-LEVTSMRDFWgllgmnvpfaailcvlcwr 247
Cdd:COG2223 158 ----------WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDqLEALRDPRFW------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 248 lqkvgflnagtyplalgavliwfifqtwgiirtnrelimgtktypkedryefkqvaILELTYIVNFGSELAVVSMLPTFF 327
Cdd:COG2223 209 --------------------------------------------------------LLSLLYFGTFGSFIGFSSWLPPYL 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 328 ETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGsRKNTMAFLTGGLGIGYLVMSMIkpgtfsgTTGIIIAVLITML 407
Cdd:COG2223 233 VDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG-GRRVLLIVFALMALGLLLLALA-------LGSLWLFLVLFLL 304
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 408 ASFFVQSGEGATFALVP-LVKRRVTGQVAGLVGAYGNVGAVtyltifsLLPMWMGGGKDpspeiIAASNSAFFQVLGVAG 486
Cdd:COG2223 305 LGLALGGGNGAVFALVPdIFPTKNAGAVYGLVGAAGGLGGF-------LGPLLFGALLD-----ATGSYTAAFLVFAVLA 372
|
490
....*....|....*.
gi 113882946 487 LIVAFFCFFFLKEPKG 502
Cdd:COG2223 373 LVALVLTLLLYRRPRR 388
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
11-501 |
2.70e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 98.40 E-value: 2.70e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 11 RYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 91 PCLMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSfsggf 169
Cdd:COG2271 88 ATLLFGFATSFWQLLLLRFLLGLgEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFG----- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 170 elpsgavlnWRGAIALTGIISAVYGFIYyfnvsdtppgktyqkpertaglevtsmrdFWGLLGMNVpfaailcvlcwrlq 249
Cdd:COG2271 163 ---------WRAAFLILGLPGLLLALLR-----------------------------FWLLALAYF-------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 250 kvgflnagtyplalGAVLIWFIFQTWgiirtnrelimgtktypkedryefkqvaileltyivnfgselavvsmLPTFFET 329
Cdd:COG2271 191 --------------LVYFALYGFLTW-----------------------------------------------LPTYLVE 209
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 330 TFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKNTMAFLTGGLGIGYLVMsmikpgtFSGTTGIIIAVLITMLAS 409
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLL-------LALLPSPALAIALLFLAG 282
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 410 FFVQSGEGATFALVP-LVKRRVTGQVAGLVGAYGNVGAVtyltifsLLPMWMGGGKDpspeiiAASNSAFFQVLGVAGLI 488
Cdd:COG2271 283 FGLGGAFGLLWALAAeLFPKKARGTASGLVNTFGFLGGA-------LGPLLVGYLLD------ATGYQAAFLLLAALALL 349
|
490
....*....|...
gi 113882946 489 VAFFCFFFLKEPK 501
Cdd:COG2271 350 AALLALLLLRETR 362
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
18-447 |
1.81e-14 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 74.76 E-value: 1.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 18 TWFAFFLTFVVWFNLAP-LATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFA 96
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPaLPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 97 SAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLSFSGGfelpsga 175
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLgAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPL----LGGLLASLFG------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 176 vlnWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAGLEVTsmrdfWGLLGMNVPFAAILCVLCWrlqkvgfln 255
Cdd:pfam07690 150 ---WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA-----WKALLRDPVLWLLLALLLF--------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 256 agtyplalgavliwfifqtwgiirtnrelimgtktypkedryefkqvaileltyivnFGSELAVVSMLPTFFEtTFDLPK 335
Cdd:pfam07690 213 ---------------------------------------------------------GFAFFGLLTYLPLYQE-VLGLSA 234
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 336 ATAGILASCFAFVNLVARPAGGLISDKLGSRKntMAFLTGGLGIGYLVMSMIKPGTFSGTTGIIIAVLITMLASFFVQSG 415
Cdd:pfam07690 235 LLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRR--RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
410 420 430
....*....|....*....|....*....|..
gi 113882946 416 EGATFALVPlvkRRVTGQVAGLVGAYGNVGAV 447
Cdd:pfam07690 313 NALVSDLAP---KEERGTASGLYNTAGSLGGA 341
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
20-446 |
2.38e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.45 E-value: 2.38e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 20 FAFFLTFVVWF---NLAPLATTVKADLGLTLGQIRTVA----ICNVALTIPArvliGMLLDKYGPRLTYSSLLVFSVIPC 92
Cdd:cd17319 7 LLFLAYVINYLdrvNISVAAPTIMKDLGLSPTQYGLIAsaffLGYALFQVPG----GWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 93 LMFASAQDFNQLVVARLLLSIVGAG-FVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSfsggfel 171
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGfFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFG------- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 172 psgavlnWRGAIALTGIISAVYGFIYYFNVsdtppgktyqkpertaglevtsmRDFWGLLGMNvpfaailcvlcwrlqkv 251
Cdd:cd17319 156 -------WRWAFIIEGLLGLLLAVLWWFYL-----------------------RQVWGLALGY----------------- 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 252 gflnagtyplaLGAVLIWFIFQTWgiirtnrelimgtktypkedryefkqvaileltyivnfgselavvsmLPTFFETTF 331
Cdd:cd17319 189 -----------FGINYALYGLLTW-----------------------------------------------LPTYLKQAR 210
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 332 DLPKATAGILASCFAFVNLVARPAGGLISDKL--GSRKnTMAFLTGGLGIGYLVMSMIkpgtfsgTTGIIIAVLITMLAS 409
Cdd:cd17319 211 GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARR-LVIIIGLLLAAVGLLLAYL-------TTSPVVAVILLSLAG 282
|
410 420 430
....*....|....*....|....*....|....*...
gi 113882946 410 FFVQSGEGATFALVP-LVKRRVTGQVAGLVGAYGNVGA 446
Cdd:cd17319 283 FGIGAASPVFWSLPAdLLPGEAAATAGGLINSGGNLGG 320
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-446 |
2.76e-13 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 71.16 E-value: 2.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 11 RYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 91 PCLMFASAQDFNQLVVARLLLSIVGAGFVIGIR-MVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLsfsggf 169
Cdd:COG2814 88 GSLLCALAPSLWLLLAARFLQGLGAGALFPAALaLIADLVPPERRGRALGLLGAGLGLGPALGPL----LGGLL------ 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 170 elpsGAVLNWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAGLevtsmrdfwgllgmnvpfaailcvlcwrlq 249
Cdd:COG2814 158 ----ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLREL------------------------------ 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 250 kvgFLNAGTYPLALGAVLIWFIFqtwgiirtnrelimgtktypkedryefkqvaileltyivnfgseLAVVSMLPTFFET 329
Cdd:COG2814 204 ---LRRPRLLLLLLLAFLLGFGF--------------------------------------------FALFTYLPLYLQE 236
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 330 TFDLPKATAGILASCFAFVNLVARPAGGLISDKLGsRKNTMAFLTGGLGIGYLVMSMikpgtfsgTTGIIIAVLITMLAS 409
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLAL--------AGSLWLLLLALFLLG 307
|
410 420 430
....*....|....*....|....*....|....*...
gi 113882946 410 FFVQSGEGATFALVP-LVKRRVTGQVAGLVGAYGNVGA 446
Cdd:COG2814 308 FGFGLLFPLLQALVAeLAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
19-494 |
1.60e-12 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 68.99 E-value: 1.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFASA 98
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 99 QDFNQLVVARLLLSIVGAGF-VIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSFSggfelpsgavl 177
Cdd:cd06174 82 PSFWLLLLGRFLLGLGSGLIdPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFG----------- 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 178 nWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAGLEVTSMRDFWGllgmnvpfaailcvlcwrlqkvgflnag 257
Cdd:cd06174 151 -WRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLK---------------------------- 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 258 tYPLALGAVLIWFIFQTWGIIrtnrelimgtktypkedryefkqvaileltyivnfgselaVVSMLPTFFETTFDLPKAT 337
Cdd:cd06174 202 -NPGLWLLLLAIFLVNLAYYS----------------------------------------FSTLLPLFLLDLGGLSVAV 240
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 338 AGILASCFAFVNLVARPAGGLISDKLGSRKNTMAFLTGGLGIGYLVMSMikpgtFSGTTGIIIAVLITMLASFFVQSGEG 417
Cdd:cd06174 241 AGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLL-----APSLLLLLLLLLLLGFGLGGLLPLSF 315
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113882946 418 ATFALVPLVKRRvtGQVAGLVGAYGNVGAVTYLTIFSLLPMWMGGgkdpspeiiaasNSAFFQVLGVAGLIVAFFCF 494
Cdd:cd06174 316 ALIAELFPPEIR--GTAFGLLNTFGFLGGAIGPLLAGFLLAATFG------------LTGAFLVLAVLLLLAAILLL 378
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
19-205 |
5.53e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.24 E-value: 5.53e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFASA 98
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 99 QDFNQLVVARLLLSIV-GAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLsfsggfelpsgavL 177
Cdd:TIGR00881 81 TSLWVMAALWALNGIFqGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAEL-------------Y 147
|
170 180
....*....|....*....|....*...
gi 113882946 178 NWRGAIALTGIISAVYGFIYYFNVSDTP 205
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRDSP 175
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
19-456 |
2.24e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 59.17 E-value: 2.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTyssLLVFSVIPCLMFASA 98
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRV---LAVGLLLMGAAALLM 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 99 QDFNQLVVARLLLSIVGAGFVI----GIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSFSGGFELPsg 174
Cdd:cd17475 79 ALVGSYPVLLVLLFLVGAGYGSvqpgGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVA-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 175 avlnwrgaiALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAGLEVTSMRDFWgllgmNVPFAAILCVlcwrlqkvgfl 254
Cdd:cd17475 157 ---------GLVSILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVW-----LIAIAGALLV----------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 255 nagtyplalgavliwfifqtwgiirtnrelimgtktypkedryefkqvaileltyivnfGSELAVVSMLPTFFETTFDLP 334
Cdd:cd17475 212 -----------------------------------------------------------APQFALLTFLLLFLHDHLGLS 232
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 335 KATAGILASCFAFVNLVARPAGGLISDKL--GSRKNTMAFLTGGLGIGYLVMSMIKPGTFSGttgiiIAVLITMLASFFV 412
Cdd:cd17475 233 VVAAGALLAVAQLGGALGRIGLGRVSDRVfgGRRRPVLVITAAIAAAALLVLSLLSPGTPLW-----LLVLLLILLGLFA 307
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 113882946 413 QSGEGATFALVP-LVKRRVTGQVAGLVGAYGNVGAVTYLTIFSLL 456
Cdd:cd17475 308 IGWNGLYLTLVAeSAGPEQAGTALGLANTINFIGIAIGPPLFGLL 352
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
7-498 |
3.11e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.57 E-value: 3.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 7 SFQGRYRTLHLTWFAFFLTFVVWFNL-------APLATTVKADLGLTLGQIrtvaicNVALTIP------ARVLIGMLLD 73
Cdd:COG2807 5 SSSARRSRRAGRWLLLLAIVLVALNLrpaitsvGPLLPEIRADLGLSATQA------GLLTTLPllafglFAPLAPRLAR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 74 KYGPRLTYSSLLVFSVIPCLMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPpKEIGLAEGIYGGWGNFGSAFS 152
Cdd:COG2807 79 RFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAgIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 153 ALTLVGLAGWLSfsggfelpsgavlnWRGAIALTGIISAVYGFIYYFNVSDTPPGKTyQKPERTAGLEVTSMRDFWGLLg 232
Cdd:COG2807 158 AGLTVPLAAALG--------------WRGALAVWALLALLALLLWLPLLRRRPAAAA-AAPAAASLRSLWRSPLAWLLT- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 233 mnvpfaailcvlcwrlqkvgflnagtypLALGAV-LIWFIFQTWgiirtnrelimgtktypkedryefkqvaileltyiv 311
Cdd:COG2807 222 ----------------------------LFFGLQsLLYYAVVAW------------------------------------ 237
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 312 nfgselavvsmLPTFFeTTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKNTMAFLTGGLGIGYLVMSmikpgt 391
Cdd:COG2807 238 -----------LPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLL------ 299
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 392 FSGTTGIIIAVLITMLASffvqsgeGATFALVPLVKRRVTGQVAGLVGAYGNVGAVTYLtIFSLLPMWMGGGKDpspeiI 471
Cdd:COG2807 300 LAPGSLPWLWAVLLGLGQ-------GGLFPLALTLIGLRARTPAEAAALSGMAQSVGYL-LAALGPLLVGALHD-----A 366
|
490 500
....*....|....*....|....*..
gi 113882946 472 AASNSAFFQVLGVAGLIVAFFCFFFLK 498
Cdd:COG2807 367 TGSWTAALLLLAALAVLMLVAGLLAGR 393
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-448 |
1.57e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 50.27 E-value: 1.57e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYG-PRLTYSSLLVFSVIPcLMFAS 97
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGrKRLLLLGLLLLAVST-LLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 98 AQDFNQLVVARLLLSIVGAGF-VIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLSFSGGFELPsgav 176
Cdd:cd17325 81 ATSYWQLLLARFLQGLASAAVwPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPL----LGGLLADALGYRAP---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 177 lnwrgaialtgiisavygFIyyfnvsdtppgktyqkpertaglevtsmrdfwgllgmnvpFAAILCVLCwrlqkvgflna 256
Cdd:cd17325 153 ------------------FL----------------------------------------VCAALALLA----------- 163
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 257 gtyplalgAVLIWFIFQTWGIIRTNRELIMGTKTYPKEDRYEFKQVAILELTYIVNFGSELAVVSMLPTFFETTFDLPKA 336
Cdd:cd17325 164 --------LVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPA 235
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 337 TAGILASCFAFVNLVARPAGGLISDKLGSRKnTMAFLTGGLGIGYLVMSMikpgtfsgTTGIIIAVLITMLASFFVQSGE 416
Cdd:cd17325 236 QIGLLFGAQGLASALSQPPAGKLSDRIGRKP-LILIGLLLSAVALLLLPL--------ATSFWLLLLLLALLGLGLGLVF 306
|
410 420 430
....*....|....*....|....*....|...
gi 113882946 417 GATFALV-PLVKRRVTGQVAGLVGAYGNVGAVT 448
Cdd:cd17325 307 PATLALLaDIVPPEGRGTAMGLFNTAFSLGMVL 339
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
11-207 |
1.62e-06 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 50.35 E-value: 1.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 11 RYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 91 PCLMFASAQDFNQLVVARLLLSIV-GAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSfsggf 169
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFqSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYG----- 155
|
170 180 190
....*....|....*....|....*....|....*...
gi 113882946 170 elpsgavlnWRGAIALTGIISAVYGFIYYFNVSDTPPG 207
Cdd:cd17312 156 ---------WRAAFLVPGIVGLVVAIILFFFLRDSPPY 184
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
9-503 |
4.36e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 4.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 9 QGRYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFS 88
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 89 VIPCLMFASAQDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLSFSGg 168
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPL----LGGLLILLG- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 169 felpsgAVLNWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAglevtSMRDFWGllgmnvpfaailcvlcwrl 248
Cdd:COG0738 159 ------LSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAA-----SLKSLLK------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 249 qkvgflnagtYPLALGAVLIWFIFqtwgiirtnrelimgtktypkedryefkqvaileltyivnFGSELAVVSMLPTFFE 328
Cdd:COG0738 209 ----------NPRLLLGGLAIFLY----------------------------------------VGAEGAIGDWLPLYLK 238
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 329 TTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKnTMAFLTGGLGIGYLVMSMikpgtfsgTTGIIIAVLITMLA 408
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVR-LLRLSALLAAVGLLLALL--------APGPWLALIGLALV 309
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 409 SFFVQSGEGATFALVPLVKRRVTGQVAGLVGAYGNVGavtyltiFSLLPMWMGGGKDpspeiiAASNSAFFQVLGVAGLI 488
Cdd:COG0738 310 GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVG-------GAIGPPLIGFLAD------AFGLRAAFLVPLVCYLL 376
|
490
....*....|....*
gi 113882946 489 VAFFCFFFLKEPKGS 503
Cdd:COG0738 377 ILLLALALKRKRRKK 391
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
317-501 |
7.00e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 48.36 E-value: 7.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 317 LAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISD----KLGSRKNTMAFLTGGLGIGYLVMSMIKPgtF 392
Cdd:COG2211 27 GLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLALSFVLLFTAPD--L 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 393 SGTTGIIIAVLITMLASFFVQSGEGATFALVPLV----KRRvtGQVAGLVGAYGNVGAVTYLTIFSLLPMWMGGGKdpsp 468
Cdd:COG2211 105 SPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELtpdyEER--TRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA---- 178
|
170 180 190
....*....|....*....|....*....|...
gi 113882946 469 eiiAASNSAFFQVLGVAGLIVAFFCFFFLKEPK 501
Cdd:COG2211 179 ---ALGYRLTALIFAVLGLLAFLLTFFGTKERP 208
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-192 |
1.08e-05 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 47.74 E-value: 1.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 20 FAFFLTFVVWFNLAPL---ATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYG-PRLTYSSLLVFSVIPCLMf 95
Cdd:TIGR00895 21 LSFLIMLMDGYDLAAMgfaAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGrRRVLLWSILLFSVFTLLC- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 96 ASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLsfsggfelpsG 174
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLgLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGF----LAGWL----------I 165
|
170
....*....|....*...
gi 113882946 175 AVLNWRGAIALTGIISAV 192
Cdd:TIGR00895 166 PVFGWRSLFYVGGIAPLL 183
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
11-160 |
1.35e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 47.21 E-value: 1.35e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 11 RYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 113882946 91 PCLMFASAQD--FNQLVVARLLLSIVGAGFV-IGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLA 160
Cdd:cd17316 256 LALPLFYLLSgsPTLLLLLLFILSFFVGGVWgALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLL 328
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
7-279 |
1.47e-05 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 47.11 E-value: 1.47e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 7 SFQGRYRTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLV 86
Cdd:COG0477 8 PTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 87 FSVIPCLMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSf 165
Cdd:COG0477 88 LFGLASLLCGLAPSPELLIAARALQGIgAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 166 sggfelpsgavlnWRGAIALTGIISAVyGFIYYFNVSDTPPGKTYQKPERTAGLEVTSMRDFWGLLGMNVPFAAILCVLC 245
Cdd:COG0477 167 -------------WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLAL 232
|
250 260 270
....*....|....*....|....*....|....
gi 113882946 246 WRLQKVGFLNAGTYPLALGAVLIWFIFQTWGIIR 279
Cdd:COG0477 233 LLAGAALLLLLALLLLALLLLLALLLLAALLLLL 266
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
19-205 |
2.61e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 46.47 E-value: 2.61e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWF-------NLAPLATTVKADLGLTLGQIRTVAIC-NVALTIpARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:cd17345 2 WQVFLGIFIGYAgyylvrnNFSLAQPYLIEQYGLSKTEIGLIGSAlSIAYGL-SKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 91 PCLMFASAQ----DFNQLVVARLLLSIV-GAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFsaltLVGLAGWLSF 165
Cdd:cd17345 81 INILIGFVPsatsSVGLMFILLFLNGWFqGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGL----VGPLAGLGLA 156
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 113882946 166 SGGfelpsgaVLNWRGAIALTGIISAVYGFIYYFNVSDTP 205
Cdd:cd17345 157 IFG-------DGWWRGAFIFPAIIAIIVAVIVLFLGKDTP 189
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
20-454 |
4.00e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 46.08 E-value: 4.00e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 20 FAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVL---IGMLLDKYGPRLTYSSLLVFSVIPCLMFA 96
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLgpiVGRLSDLFGRRWFFIGGNLLGVVGSIVAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 97 SAQDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFS-----ALTLVGLAGWLSFsggfel 171
Cdd:cd06179 81 TAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPNKYRGLVQGVVNLVASPGSALGpliagALVEANAAGWRWI------ 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 172 psgavlnWRGAIALTGiISAVYGFIYYFnvsdtPPgkTYQKPERTAGLEVTSMRDFWGLLGMNVPFAAILCVLCWRLQKV 251
Cdd:cd06179 155 -------FYINAIFNA-LALILLFFFYH-----PP--PRPQLHGSSTRQKLKRLDWVGLFLLIAGLVLFLLGLSWGGNPY 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 252 GFLNAGTY-PLALGAVLIwFIFQTWGIIRTNRELIMgtktypkedRYEFKQVAILELTYIVNFGSELAVVSML---PTFF 327
Cdd:cd06179 220 PWSSAHVIaPLVIGGVLL-IAFGLYEWKGTKDGLLP---------PRLLFRGRNFALILIVAFVEGMIFYSLNifwPQQI 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 328 ETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKNTMAFLTGGLGIGYLVMSMIKPGTfsgttgIIIAVLITML 407
Cdd:cd06179 290 SLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLALLALITPDN------KALAIAFSVL 363
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 113882946 408 ASFFVQSGEGATFALVPL-VKRRVTGQVAGLVGAYGNVGAVTYLTIFS 454
Cdd:cd06179 364 AGIGIGGPLVLAIVIVQLsVPPEDIGTASGLLGSARALGGAVGTAIFT 411
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
307-501 |
5.48e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 45.66 E-value: 5.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 307 LTYIVNFGSELAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGsRKNTMAFLTGGLGIGYLVMSM 386
Cdd:COG2211 235 LAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG-KKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 387 IKPGTfsgttgIIIAVLITMLASFFVQSGEGATFALVPLV--------KRRVTGQVAGLVGAYGNVGAVTYLTIFSLLPM 458
Cdd:COG2211 314 LGPGN------LWLLLVLAALAGIGLGAILVLPWAMLADVvdydewktGRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 113882946 459 WMG--GGKDPSPEIIAASNSAFFqVLGVAGLIVAFFCFFFLKEPK 501
Cdd:COG2211 388 LFGyvAGAAQSPSALTGIRLLFF-LLPAVLLLLAALLLLFYPLTR 431
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
11-150 |
9.78e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.58 E-value: 9.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 11 RYRTLHLTWFAFFLTFVVWFNLAPLAttVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVI 90
Cdd:COG2814 208 RLLLLLLLAFLLGFGFFALFTYLPLY--LQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLAL 285
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113882946 91 PCLMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSA 150
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFgFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGP 346
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
15-240 |
1.14e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 44.53 E-value: 1.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 15 LHLTWFAFFLTFVVWFNLAPLATT-VKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCL 93
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIyLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 94 MFASAQDFNQLVVARLLLSIVGAGFVIGIR-MVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLsfsggfelp 172
Cdd:cd17329 81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEaMIADVTTPENRTRAFSLLYWAINLGVAIGPL----LGGLL--------- 147
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 173 sgAVLNWRGAIALTGIISAVYGFIYYFNVSDTPPGKTYQKPERTAGLEVTSMRD--FWGLLGMNVPFAAI 240
Cdd:cd17329 148 --LLYSFRLLFLAAAVLFLLAALVLLFLLPETRPKRRAAEKTEILRGYKIVLRDraFLLFLLASFLISLI 215
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
19-208 |
1.91e-04 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 43.69 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATTVKADLGLTL---GQIRTVAICNVALTIParvLIGMLLDKYGPRLTYSSLLVFSVIPCLMF 95
Cdd:cd17324 5 ALAAFAIGTTEYVIQGLLPDIARDFGVSVaqaGLLVSAYALGYALGAL---LLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 96 ASAQDFNQLVVARLLLSIVGAGFV-IGIRMVAEWFPPKEIGLAEGIYGGwgnfGSAFSALTLVGLAGWLsfsggfelpsG 174
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWaIAAAYAADLVPPEKRGRAIGLVFS----GLTLGLVLGRPLGGLL----------G 147
|
170 180 190
....*....|....*....|....*....|....
gi 113882946 175 AVLNWRGAIALTGIISAVYGFIYYFNVSDTPPGK 208
Cdd:cd17324 148 QLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
70-205 |
1.96e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 43.78 E-value: 1.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 70 MLLDKYGPRLTYSSLLV-FSVIPCLMFAsAQDFNQLVVARLLLSIVGAGFVIGIRMV-AEWFPPKEIGLAEGIYGGWGNF 147
Cdd:cd17327 63 LLLQRFPPSKWLSVFIVlWGLLTLLTAA-VKNFGGLIALRFFLGLFESGVFPGFILYlGMWYKREEQAKRIAFFYAAAGL 141
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 113882946 148 GSAFSALtlvglagwLSFSGGFELPSGAVLNWRGAIALTGIISAVYGFIYYFNVSDTP 205
Cdd:cd17327 142 GSIFGGL--------LAYGVFKILGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNP 191
|
|
| MFS_MFSD1 |
cd17340 |
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily ... |
19-199 |
2.08e-04 |
|
Major facilitator superfamily domain-containing protein 1; Human major facilitator superfamily domain-containing protein 1 (MFSD1) is also called smooth muscle cell-associated protein 4 (SMAP-4). The function of MFSD1 is still unknown. Its expression is affected by altered nutrient intake. During starvation, expression of MFSD1 is downregulated in anterior brain sections in mice while it is upregulated in the brainstem. In mice raised on high-fat diet, MFSD1 is specifically downregulated in brainstem and hypothalamus. MFSD1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340898 [Multi-domain] Cd Length: 394 Bit Score: 43.80 E-value: 2.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWF---NLAPLATTVKADLGLTLGQIRTV----AICNVALTIparvLIGMLLDKY-GPRL---TYSSLLVF 87
Cdd:cd17340 2 FLMCFLGFGSYFcydNPAALQKQFIEDMDINTSQFMLLysvySWPNVVLCF----FGGFLIDRVfGIRLgtiIFSLLVLI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 88 SVIPCLMFASAQDFNQLVVARLLLSIVGAGFVIGIR-MVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSFS 166
Cdd:cd17340 78 GQLIFALGALTNLFWLMLVGRFIFGIGGESLAVAQNtYAVSWFKGKELNLVFGLQLSFARIGSTVNFNVMPPIYKRISDF 157
|
170 180 190
....*....|....*....|....*....|...
gi 113882946 167 GGFELPSGAVLnWRGAIalTGIISAVYGFIYYF 199
Cdd:cd17340 158 YSGYKSLGVAL-WIGAI--TCLFSLICAIILGL 187
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-199 |
2.69e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 43.33 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 17 LTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFA 96
Cdd:cd17325 204 LFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 97 SAQDFNQLVVARLLLSIVGAGFVIGIR-MVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWLSFSGGFELPsga 175
Cdd:cd17325 284 LATSFWLLLLLLALLGLGLGLVFPATLaLLADIVPPEGRGTAMGLFNTAFSLGMVLGPL----LGGFLYDAFGFATP--- 356
|
170 180
....*....|....*....|....
gi 113882946 176 vlnwrgaIALTGIISAVYGFIYYF 199
Cdd:cd17325 357 -------FLAAAALLLLAAVLFLL 373
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
67-169 |
4.05e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.64 E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 67 LIGMLLDKYGPRLTYSSLLVFSVIPCLMFASAQDFNQLVVARLLLSIVGAG---FVIGIRMVAEWFPPKEiGLAEGIYGG 143
Cdd:cd17355 57 FVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGtlaAVAFATVAAWWFERRR-GLALGILTA 135
|
90 100
....*....|....*....|....*.
gi 113882946 144 WGNFGSAFSALTLVGLAGWLSFSGGF 169
Cdd:cd17355 136 GGGLGSLVFLPLGAALIEAFGWRTAL 161
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
307-518 |
6.73e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.02 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 307 LTYIVNFGSELAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKnTMAFLTGGLGIGYLVMSM 386
Cdd:pfam07690 3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR-VLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 387 ikpgTFSGTTGIIIAVLITMLASFFVQSGEGATFALVPLVKRrvtGQVAGLVGAYGNVGAVTYLTIFSLLpmwmgggkdp 466
Cdd:pfam07690 82 ----ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER---GRALGLVSAGFGLGAALGPLLGGLL---------- 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 113882946 467 speIIAASNSAFFQVLGVAGLIVAFFCFFFLKEPKGSFDDLHEGETASPEFA 518
Cdd:pfam07690 145 ---ASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVA 193
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
304-424 |
8.62e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.83 E-value: 8.62e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 304 ILELTYIVNFGSELAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGsRKNTMAFLTGGLGIGYLV 383
Cdd:cd17353 217 LLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIG-RKNTLSIAFLIQGVAMFL 295
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 113882946 384 MSMIkpgtfsgtTGIIIAVLITMLASFFvqsGEGATFALVP 424
Cdd:cd17353 296 LPFI--------GSVAVLFVLGVALIGF---CYGGGFALFP 325
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
25-199 |
9.02e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.77 E-value: 9.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 25 TFVVWFN---LAPLATTVKADLGLTLGQIR-TVAICNVALTIPArVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFASAQD 100
Cdd:cd17321 5 VFLAALDvtiVNVALPTIARDLGASPSQLQwVVNAYLLAFAALL-LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 101 FNQLVVARLLLSIVGAGFV-IGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSAL---TLVGLAGWLS-FsgGFELPSGA 175
Cdd:cd17321 84 LAFLIAARALQGIGAAAIMpASLALIAATFPGERRGRALGLWGAVVGIGAALGPLlggLLLELFGWRWiF--LINVPIGL 161
|
170 180
....*....|....*....|....*....
gi 113882946 176 VL-----NWRGAIALTGIISAVYGFIYYF 199
Cdd:cd17321 162 VAlllarTFSGAVLAAFLLGAALGGLLFL 190
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
67-177 |
1.11e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 41.41 E-value: 1.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 67 LIGMLLDKYGPRLTYSSLLVFSVIPCLMFASAQDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGN 146
Cdd:cd17504 50 ILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFPPERVPVAQGILSATFG 129
|
90 100 110
....*....|....*....|....*....|....*
gi 113882946 147 FGSAFSALtlvgLAGW----LSFSGGFELPSGAVL 177
Cdd:cd17504 130 IGAGIGLP----LGGWivqhLGWRWIFWTAAPVAV 160
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
300-456 |
1.26e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.05 E-value: 1.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 300 KQVAILELTYIVNFGSELAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGsRKNTMAFLTGGLGI 379
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG-RKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 113882946 380 GYLVMSMIKPGTFsgtTGIIIAVLITMLASFFVQSGEGATFALVPLVKRRVTGqvAGLVGAYGNVGAVTYLTIFSLL 456
Cdd:cd17316 256 LALPLFYLLSGSP---TLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATG--VGLSYNLGRLGGGGAPPLIALL 327
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-196 |
1.33e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 41.04 E-value: 1.33e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 19 WFAFFLTFVVWFNLAPLATT-VKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFAS 97
Cdd:COG2211 234 LLAYLLFFLALALVAALLLYyFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 98 AQDFNQLVvarLLLSIVGAGFVIGIRM---------VAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWL----S 164
Cdd:COG2211 314 LGPGNLWL---LLVLAALAGIGLGAILvlpwamladVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLlalfG 390
|
170 180 190
....*....|....*....|....*....|..
gi 113882946 165 FSGGFELPSGAVLNWRGAIALTGIISAVYGFI 196
Cdd:COG2211 391 YVAGAAQSPSALTGIRLLFFLLPAVLLLLAAL 422
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-153 |
1.50e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.86 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 17 LTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGPRLTYSSLLVFSVIPCLMFA 96
Cdd:pfam07690 204 WLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLL 283
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 113882946 97 SAQDFNQLVVARLLLSIVGAGFVIG----IRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSA 153
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVfpalNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
307-496 |
2.77e-03 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 40.23 E-value: 2.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 307 LTYIVNFGSELAVVSMLPTFFETTFDLPKATAGILASCFAFVNLVARPAGGLISDKLGSRKnTMAFLTGGLGIGYLVMSM 386
Cdd:cd17321 175 LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRL-VLVAGLLLTAVGLLLLAL 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 387 IKPGtfSGTTGIIIAVLITMLASFFVQSgeGATFALVPLVKRRVTGQVAGLVGAYGNVGAVTYLTIFSLL------PMWM 460
Cdd:cd17321 254 LGAD--SSVWLLLPGLVLLGLGLGLFAT--PLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALltaglsANLG 329
|
170 180 190
....*....|....*....|....*....|....*.
gi 113882946 461 GGGKDPSPEIIAASNSAFFQVLGVAGLIVAFFCFFF 496
Cdd:cd17321 330 DSGVAALLSAAAAAFAAGFHLAFLVAAALALLAALL 365
|
|
| PRK15034 |
PRK15034 |
nitrate/nitrite transport protein NarU; Provisional |
304-431 |
2.95e-03 |
|
nitrate/nitrite transport protein NarU; Provisional
Pssm-ID: 184994 [Multi-domain] Cd Length: 462 Bit Score: 40.25 E-value: 2.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 304 ILELTYIVNFGSELAVVSMLPTFFETTFdlPKATAGILASCFAFVNLVARPAGGLISDKLGSRKNTMA-FLTGGLGIGYL 382
Cdd:PRK15034 256 LLSLLYLATFGSFIGFSAGFAMLAKTQF--PDVNILRLAFFGPFIGAIARSVGGAISDKFGGVRVTLInFIFMAIFSALL 333
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 113882946 383 VMSMikPGTFSGTtgiIIAVLITMLASFFVQS-GEGATFALVPLVKRRVT 431
Cdd:PRK15034 334 FLTL--PGTGSGN---FIAFYAVFMGLFLTAGlGSGSTFQMIAVIFRQIT 378
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-199 |
3.38e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.89 E-value: 3.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 15 LHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVAL--TIPARVLIGMLLDKYGPRLTYSSLLVFSVIPC 92
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFlgRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 93 LMFASAQDFNQLVVARLLLSI-VGAGFVIGIRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALTLVGLAGWLSFSGGFE- 170
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIgIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWGWRi 160
|
170 180 190
....*....|....*....|....*....|....*
gi 113882946 171 ------LPSGAVLNWRGAIALTGIISAVYGFIYYF 199
Cdd:cd17316 161 lfligaLPALLALLLRRRTLLLILLWFFISFGYYG 195
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
67-172 |
3.76e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.48 E-value: 3.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 67 LIGMLLDKYGPRLTYSSLLVFSVIPCLMFASAQDFNQLVVARLLLSIVGAGFVIGIRMVAEWFPPKEIGLAEGIyggwgn 146
Cdd:cd17330 53 LWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGI------ 126
|
90 100
....*....|....*....|....*...
gi 113882946 147 FGSAFSALTLVG--LAGWLSFSGGFELP 172
Cdd:cd17330 127 ISAAFGLGFILGpaLGGFLSTPYGYALP 154
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
13-169 |
9.64e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 9.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 13 RTLHLTWFAFFLTFVVWFNLAPLATTVKADLGLTLGQIRTVAICNVALTIPARVLIGMLLDKYGP----RLTYSSLLVFS 88
Cdd:cd17319 180 QVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRgarrLVIIIGLLLAA 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113882946 89 VIPCLMFASAQdfnqLVVARLLLSIVGAGFVIG----IRMVAEWFPPKEIGLAEGIYGGWGNFGSAFSALtlvgLAGWL- 163
Cdd:cd17319 260 VGLLLAYLTTS----PVVAVILLSLAGFGIGAAspvfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPL----LIGYLv 331
|
170
....*....|
gi 113882946 164 ----SFSGGF 169
Cdd:cd17319 332 datgSYTAAF 341
|
|
| |
