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Conserved domains on  [gi|113525055|emb|CAJ91400|]
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uncharacterized conserved protein [Cupriavidus necator H16]

Protein Classification

Ub-Mut7C and Mut7-C domain-containing protein( domain architecture ID 10627971)

Ub-Mut7C and Mut7-C domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mut7-C pfam01927
Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C ...
 96-240 2.33e-66

Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C terminus.


:

Pssm-ID: 426515  Cd Length: 146  Bit Score: 202.49  E-value: 2.33e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055   96 MRFVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYVRAIKSQLQVREIFARL 175
Cdd:pfam01927   1 PRFLLDAMLGKLARYLRMLGYDTLYDNDYEDDELLRIAAKEGRILLTRDRGLLKRRELTHGVYVRSLDPEEQLREVIARL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113525055  176 DLARSARP-FSLCLDCNAPLRSLDAAGAAGRVPQGVLERHRSFVTCDQCRRVFWEGSHWRCMRALV 240
Cdd:pfam01927  81 GLALSLKPeFSRCLLCNGPLRPVEKEEVAGRVPPKVYERYDEFWRCPGCGRVYWEGSHWRRMRELL 146
Ub-Mut7C pfam14451
Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of ...
 1-81 1.33e-42

Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role.


:

Pssm-ID: 433962  Cd Length: 81  Bit Score: 139.79  E-value: 1.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055    1 MVTATFRFYEELNDFLAPDQRRRDLSCACARAATVKHMIEALGVPHTEVELILVNGESSGFERQLCDGDRVSVYPKFERL 80
Cdd:pfam14451   1 MPTATFRFYAELNDFLPRARRQRTAARAFDGGATVKHMIEALGVPHTEVGLILVNGESVPFSHIPADGDRVAVYPVFEAL 80


                  .
gi 113525055   81 D 81
Cdd:pfam14451  81 D 81
 
Name Accession Description Interval E-value
Mut7-C pfam01927
Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C ...
 96-240 2.33e-66

Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C terminus.


Pssm-ID: 426515  Cd Length: 146  Bit Score: 202.49  E-value: 2.33e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055   96 MRFVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYVRAIKSQLQVREIFARL 175
Cdd:pfam01927   1 PRFLLDAMLGKLARYLRMLGYDTLYDNDYEDDELLRIAAKEGRILLTRDRGLLKRRELTHGVYVRSLDPEEQLREVIARL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113525055  176 DLARSARP-FSLCLDCNAPLRSLDAAGAAGRVPQGVLERHRSFVTCDQCRRVFWEGSHWRCMRALV 240
Cdd:pfam01927  81 GLALSLKPeFSRCLLCNGPLRPVEKEEVAGRVPPKVYERYDEFWRCPGCGRVYWEGSHWRRMRELL 146
Mut7-C COG1656
Uncharacterized conserved protein, contains PIN-related Mut7-C RNAse domain [General function ...
 96-246 2.64e-66

Uncharacterized conserved protein, contains PIN-related Mut7-C RNAse domain [General function prediction only];


Pssm-ID: 441262  Cd Length: 155  Bit Score: 202.40  E-value: 2.64e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055  96 MRFVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYVRAIKSQLQVREIFARL 175
Cdd:COG1656    1 PRFLLDVMLGKLARWLRMLGFDTLYANDIDDDELLAIAREEGRILLTRDRGLLKRAEVTRGVLLRSTDPEEQLAEVLRRF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113525055 176 DLAR-SARPFSLCLDCNAPLRSLDAAGAAGRVPQGVLERHRSFVTCDQCRRVFWEGSHWRCMRALVDELVRR 246
Cdd:COG1656   81 GLDLeLDRPFTRCLRCNGPLEPVDKEEVADRVPPYVRERYDEFWRCPKCGKVYWRGSHWRRMRERLERLLKR 152
Ub-Mut7C pfam14451
Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of ...
 1-81 1.33e-42

Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role.


Pssm-ID: 433962  Cd Length: 81  Bit Score: 139.79  E-value: 1.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055    1 MVTATFRFYEELNDFLAPDQRRRDLSCACARAATVKHMIEALGVPHTEVELILVNGESSGFERQLCDGDRVSVYPKFERL 80
Cdd:pfam14451   1 MPTATFRFYAELNDFLPRARRQRTAARAFDGGATVKHMIEALGVPHTEVGLILVNGESVPFSHIPADGDRVAVYPVFEAL 80


                  .
gi 113525055   81 D 81
Cdd:pfam14451  81 D 81
PIN_Mut7-C-like cd18771
uncharacterized subgroup of the Mut7-C-like family of the PIN domain superfamily; The ...
 98-159 9.89e-20

uncharacterized subgroup of the Mut7-C-like family of the PIN domain superfamily; The Mut7-C-like family of the PIN domain superfamily includes the C-terminal domain of Caenorhabditis elegans Mut-7 (also known as exonuclease 3'-5' domain-containing protein 3 homolog). Mut-7 is involved in RNA interference (RNAi) and transposon silencing in C. elegans. The Mut7-C PIN domain family is recognized as a genuine PIN domain, however it is not included it in the CDD PIN domain superfamily hierarchical model as it is lacks a core strand and helix (H3 and S3). The PIN (PilT N terminus) domain belongs to a large nuclease superfamily, and were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Other PIN domain families are: the FEN-like PIN domain family which includes the PIN domains of Flap endonuclease-1 (FEN1), Exonuclease-1 (EXO1), Mkt1, Gap endonuclease 1 (GEN1), and Xeroderma pigmentosum complementation group G (XPG) nuclease, 5'-3' exonucleases of DNA polymerase I and bacteriophage T4- and T5-5' nucleases; the VapC-like PIN domain family which includes toxins of prokaryotic toxin/antitoxin operons FitAB and VapBC, as well as, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and, rRNA-processing protein Fcf1; the LabA-like PIN domain family which includes the PIN domains of Synechococcus elongatus LabA (low-amplitude and bright); the PRORP-Zc3h12a-like PIN domain family which includes the PIN domains of of RNase P (PRORP), ribonuclease Zc3h12a; and Bacillus subtilis YacP/Rae1-like PIN domains.


Pssm-ID: 350853  Cd Length: 62  Bit Score: 80.22  E-value: 9.89e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113525055  98 FVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYV 159
Cdd:cd18771    1 FLLDVHLGTLARLLRLLGFDTAYDNTYADATLAALADAEDRILLSRDRGLLKRRGIRRGAFV 62
 
Name Accession Description Interval E-value
Mut7-C pfam01927
Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C ...
 96-240 2.33e-66

Mut7-C RNAse domain; RNAse domain of the PIN fold with an inserted Zinc Ribbon at the C terminus.


Pssm-ID: 426515  Cd Length: 146  Bit Score: 202.49  E-value: 2.33e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055   96 MRFVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYVRAIKSQLQVREIFARL 175
Cdd:pfam01927   1 PRFLLDAMLGKLARYLRMLGYDTLYDNDYEDDELLRIAAKEGRILLTRDRGLLKRRELTHGVYVRSLDPEEQLREVIARL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 113525055  176 DLARSARP-FSLCLDCNAPLRSLDAAGAAGRVPQGVLERHRSFVTCDQCRRVFWEGSHWRCMRALV 240
Cdd:pfam01927  81 GLALSLKPeFSRCLLCNGPLRPVEKEEVAGRVPPKVYERYDEFWRCPGCGRVYWEGSHWRRMRELL 146
Mut7-C COG1656
Uncharacterized conserved protein, contains PIN-related Mut7-C RNAse domain [General function ...
 96-246 2.64e-66

Uncharacterized conserved protein, contains PIN-related Mut7-C RNAse domain [General function prediction only];


Pssm-ID: 441262  Cd Length: 155  Bit Score: 202.40  E-value: 2.64e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055  96 MRFVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYVRAIKSQLQVREIFARL 175
Cdd:COG1656    1 PRFLLDVMLGKLARWLRMLGFDTLYANDIDDDELLAIAREEGRILLTRDRGLLKRAEVTRGVLLRSTDPEEQLAEVLRRF 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113525055 176 DLAR-SARPFSLCLDCNAPLRSLDAAGAAGRVPQGVLERHRSFVTCDQCRRVFWEGSHWRCMRALVDELVRR 246
Cdd:COG1656   81 GLDLeLDRPFTRCLRCNGPLEPVDKEEVADRVPPYVRERYDEFWRCPKCGKVYWRGSHWRRMRERLERLLKR 152
Ub-Mut7C pfam14451
Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of ...
 1-81 1.33e-42

Mut7-C ubiquitin; This member of the ubiquitin superfamily is found at the N-terminus of Mut7-C like RNAses, suggestive of an RNA-binding role.


Pssm-ID: 433962  Cd Length: 81  Bit Score: 139.79  E-value: 1.33e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055    1 MVTATFRFYEELNDFLAPDQRRRDLSCACARAATVKHMIEALGVPHTEVELILVNGESSGFERQLCDGDRVSVYPKFERL 80
Cdd:pfam14451   1 MPTATFRFYAELNDFLPRARRQRTAARAFDGGATVKHMIEALGVPHTEVGLILVNGESVPFSHIPADGDRVAVYPVFEAL 80


                  .
gi 113525055   81 D 81
Cdd:pfam14451  81 D 81
PIN_Mut7-C-like cd18771
uncharacterized subgroup of the Mut7-C-like family of the PIN domain superfamily; The ...
 98-159 9.89e-20

uncharacterized subgroup of the Mut7-C-like family of the PIN domain superfamily; The Mut7-C-like family of the PIN domain superfamily includes the C-terminal domain of Caenorhabditis elegans Mut-7 (also known as exonuclease 3'-5' domain-containing protein 3 homolog). Mut-7 is involved in RNA interference (RNAi) and transposon silencing in C. elegans. The Mut7-C PIN domain family is recognized as a genuine PIN domain, however it is not included it in the CDD PIN domain superfamily hierarchical model as it is lacks a core strand and helix (H3 and S3). The PIN (PilT N terminus) domain belongs to a large nuclease superfamily, and were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Other PIN domain families are: the FEN-like PIN domain family which includes the PIN domains of Flap endonuclease-1 (FEN1), Exonuclease-1 (EXO1), Mkt1, Gap endonuclease 1 (GEN1), and Xeroderma pigmentosum complementation group G (XPG) nuclease, 5'-3' exonucleases of DNA polymerase I and bacteriophage T4- and T5-5' nucleases; the VapC-like PIN domain family which includes toxins of prokaryotic toxin/antitoxin operons FitAB and VapBC, as well as, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and, rRNA-processing protein Fcf1; the LabA-like PIN domain family which includes the PIN domains of Synechococcus elongatus LabA (low-amplitude and bright); the PRORP-Zc3h12a-like PIN domain family which includes the PIN domains of of RNase P (PRORP), ribonuclease Zc3h12a; and Bacillus subtilis YacP/Rae1-like PIN domains.


Pssm-ID: 350853  Cd Length: 62  Bit Score: 80.22  E-value: 9.89e-20
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113525055  98 FVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGRVVLTRDRELLKRRGITHGCYV 159
Cdd:cd18771    1 FLLDVHLGTLARLLRLLGFDTAYDNTYADATLAALADAEDRILLSRDRGLLKRRGIRRGAFV 62
PIN_Mut7-C-like cd18670
PIN domain at the C-terminus of Caenorhabditis elegans exonuclease Mut-7 and related domains; ...
 98-156 2.62e-09

PIN domain at the C-terminus of Caenorhabditis elegans exonuclease Mut-7 and related domains; The Mut7-C-like family of the PIN domain superfamily includes the C-terminal domain of Caenorhabditis elegans Mut-7 (also known as exonuclease 3'-5' domain-containing protein 3 homolog). Mut-7 is involved in RNA interference (RNAi) and transposon silencing in C. elegans. The Mut7-C PIN domain family is recognized as a genuine PIN domain, however it is not included it in the CDD PIN domain superfamily hierarchical model as it is lacks a core strand and helix (H3 and S3). The PIN (PilT N terminus) domain belongs to a large nuclease superfamily, and were originally named for their sequence similarity to the N-terminal domain of an annotated pili biogenesis protein, PilT, a domain fusion between a PIN-domain and a PilT ATPase domain. The structural properties of the PIN domain indicate its active center, consisting of three highly conserved catalytic residues which coordinate metal ions; in some members additional metal coordinating residues can be found while some others lack several of these key catalytic residues. The PIN active site is geometrically similar in the active center of structure-specific 5' nucleases, PIN-domain ribonucleases of eukaryotic rRNA editing proteins, and bacterial toxins of toxin-antitoxin (TA) operons. Other PIN domain families are: the FEN-like PIN domain family which includes the PIN domains of Flap endonuclease-1 (FEN1), Exonuclease-1 (EXO1), Mkt1, Gap Endonuclease 1 (GEN1), and Xeroderma pigmentosum complementation group G (XPG) nuclease, 5'-3' exonucleases of DNA polymerase I and bacteriophage T4- and T5-5' nucleases; the VapC-like PIN domain family which includes toxins of prokaryotic toxin/antitoxin operons FitAB and VapBC, as well as, eukaryotic ribonucleases such as Smg6, ribosome assembly factor NOB1, exosome subunit Rrp44 endoribonuclease and, rRNA-processing protein Fcf1; the LabA-like PIN domain family which includes the PIN domains of Synechococcus elongatus LabA (low-amplitude and bright); the PRORP-Zc3h12a-like PIN domain family which includes the PIN domains of of RNase P (PRORP), ribonuclease Zc3h12a; and Bacillus subtilis YacP/Rae1-like PIN domains. Matelska et al. recently classified PIN-like domains into distinct groups, this family includes some sequences belonging to two of these, PIN _10 and PIN_16.


Pssm-ID: 350850  Cd Length: 65  Bit Score: 52.19  E-value: 2.62e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 113525055  98 FVADAHLGGLAHLLRMTGFDTLYDNHFEDSEIERIAVDQGR-VVLTRDR--ELLKRRGITHG 156
Cdd:cd18670    1 VLLDENLPRFGANLRRAGIDVIVPKLVSDFEKYAKAIEEKSyEVLTMDYdnELIAIPGLFFG 62
COG4634 COG4634
Predicted nuclease, contains PIN domain, potential toxin-antitoxin system component [General ...
 96-155 1.40e-06

Predicted nuclease, contains PIN domain, potential toxin-antitoxin system component [General function prediction only];


Pssm-ID: 443672  Cd Length: 113  Bit Score: 46.02  E-value: 1.40e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 113525055  96 MRFVADAHLG-GLAHLLRMTGFDTLY-----DNHFEDSEIERIAVDQGRVVLTRDR---ELLKRRGITH 155
Cdd:COG4634    1 MKFLLDENLSpRLVEWLREAGHDVLHvrdlgLPGASDEEILEYARREGRIIVTKDKdfgELLALSGAPP 69
DUF5615 pfam18480
Domain of unknown function (DUF5615); This is a domain of unknown function found in potential ...
 96-156 5.43e-06

Domain of unknown function (DUF5615); This is a domain of unknown function found in potential toxin-antitoxin system component.


Pssm-ID: 465782  Cd Length: 77  Bit Score: 43.28  E-value: 5.43e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 113525055   96 MRFVADAHLG-GLAHLLRMTGFDTLY-----DNHFEDSEIERIAVDQGRVVLTRDR---ELLKRRGITHG 156
Cdd:pfam18480   1 MKLLADENLSpRLVELLRDLGHDVLHvrelgLPGASDEEILEYAKEEGRIIVTKDKdfgELHLLGGPPPG 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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