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Conserved domains on  [gi|1134776224]
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Chain A, Ankyrin-repeat protein B

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 20-59 5.18e-07

F-box-like; This is an F-box-like family.


:

Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 5.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
77-171 7.49e-07

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.03  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNSYhlNRTPLLAAIEGKAYQTANYLwRKYTFDPNFKDNYGDSPISLLKKQLANP 156
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDND--GETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDLAAENGNLE 233

                          90
                  ....*....|....*
gi 1134776224 157 AFKDKEKKQIRALIR 171
Cdd:COG0666   234 IVKLLLEAGADLNAK 248
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 20-59 5.18e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 5.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-171 7.49e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.03  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNSYhlNRTPLLAAIEGKAYQTANYLwRKYTFDPNFKDNYGDSPISLLKKQLANP 156
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDND--GETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDLAAENGNLE 233

                          90
                  ....*....|....*
gi 1134776224 157 AFKDKEKKQIRALIR 171
Cdd:COG0666   234 IVKLLLEAGADLNAK 248
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 21-55 1.41e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 43.20  E-value: 1.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1134776224  21 SDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAN 55
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-146 4.53e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 4.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNsyHLNRTPLLAAIEGKAYQTANYLWRKYTFDpnfKDNYGDSPI 146
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD--KNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTAL 65
 
Name Accession Description Interval E-value
F-box-like pfam12937
F-box-like; This is an F-box-like family.
 20-59 5.18e-07

F-box-like; This is an F-box-like family.


Pssm-ID: 463757 [Multi-domain]  Cd Length: 45  Bit Score: 44.40  E-value: 5.18e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSL 40
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-171 7.49e-07

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 48.03  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNSYhlNRTPLLAAIEGKAYQTANYLwRKYTFDPNFKDNYGDSPISLLKKQLANP 156
Cdd:COG0666   157 LHLAAANGNLEIVKLLLEAGADVNARDND--GETPLHLAAENGHLEIVKLL-LEAGADVNAKDNDGKTALDLAAENGNLE 233

                          90
                  ....*....|....*
gi 1134776224 157 AFKDKEKKQIRALIR 171
Cdd:COG0666   234 IVKLLLEAGADLNAK 248
F-box_SF cd09917
F-box domain superfamily; This short domain is commonly found at the N-terminus of various ...
 21-55 1.41e-06

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.


Pssm-ID: 438852  Cd Length: 35  Bit Score: 43.20  E-value: 1.41e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1134776224  21 SDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAN 55
Cdd:cd09917     1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
51-146 6.87e-06

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 44.94  E-value: 6.87e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  51 NRLANDKHLELHQLRQQHIKRELWGNLMVAARSNNLEEVKKILKKGIDPTQTNSYhlNRTPLLAAIEGKAYQTANYLwRK 130
Cdd:COG0666    65 GDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKD--GETPLHLAAYNGNLEIVKLL-LE 141

                          90
                  ....*....|....*.
gi 1134776224 131 YTFDPNFKDNYGDSPI 146
Cdd:COG0666   142 AGADVNAQDNDGNTPL 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-146 4.53e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 40.48  E-value: 4.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNsyHLNRTPLLAAIEGKAYQTANYLWRKYTFDpnfKDNYGDSPI 146
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQD--KNGRTALHLAAKNGHLEIVKLLLEHADVN---LKDNGRTAL 65
F-box_FBXW4 cd20090
F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, ...
 19-55 5.38e-05

F-box domain found in F-box/WD repeat-containing protein 4 (FBXW4) and similar proteins; FBXW4, also called dactylin, or F-box and WD-40 domain-containing protein 4, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is likely to be involved in key signaling pathways crucial for normal limb development. It may participate in Wnt signaling and act as a novel tumor suppressor that regulates important cellular processes. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438853  Cd Length: 47  Bit Score: 39.12  E-value: 5.38e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1134776224  19 FFSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAN 55
Cdd:cd20090     1 PLLDLPDDLLFLIFSYLDPASLGRLSQVCRRLYRLIS 37
F-box_FBXO11 cd22091
F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called ...
 22-59 6.25e-05

F-box domain found in F-box only protein 11 (FBXO11) and similar proteins; FBXO11, also called FBX11, protein arginine N-methyltransferase 9 (PRMT9), or vitiligo-associated protein 1 (VIT-1), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438863  Cd Length: 45  Bit Score: 38.94  E-value: 6.25e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1134776224  22 DLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22091     3 ELPDEVLLKIFSYLLEQDLCRAAQVCKRFNTLANDPEL 40
F-box_FBXL12 cd22123
F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also ...
 20-59 8.14e-05

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438895  Cd Length: 42  Bit Score: 38.49  E-value: 8.14e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22123     1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTL 40
F-box_ScMFB1-like cd22146
F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and ...
 20-59 9.92e-05

F-box domain found in Saccharomyces cerevisiae mitochondrial F-box protein MFB1 (ScMFB1) and similar proteins; ScMFB1 is a novel mitochondria-associated F-box protein that functions to increase mitochondrial connectivity in yeast. ScMFB1 acts as a key component of a Skp1-Cdc53/Cullin-F-box protein (SCF) ubiquitin ligase complex machinery that regulates mitochondrial dynamics throughout the yeast's entire life cycle. It interacts with Skp1p in an F-box-dependent manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438917  Cd Length: 42  Bit Score: 38.39  E-value: 9.92e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22146     1 LLGLPLEILFEILIYLDIPDILNLSKTCRFLYVLLNDEIL 40
F-box_FBXL5 cd22118
F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also ...
 20-59 1.38e-04

F-box domain found in F-box/LRR-repeat protein 5 (FBXL5) and similar proteins; FBXL5, also called F-box and leucine-rich repeat protein 5, F-box protein FBL4/FBL5, or p45SKP2-like protein, is the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438890  Cd Length: 41  Bit Score: 37.70  E-value: 1.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22118     1 ISSLPPEIMLKIFSYLNPQDLCRCAQVCTKWSQLARDGSL 40
F-box_FBXL4 cd22117
F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also ...
 20-61 1.99e-04

F-box domain found in F-box/LRR-repeat protein 4 (FBXL4) and similar proteins; FBXL4, also called F-box and leucine-rich repeat protein 4, or F-box protein FBL4/FBL5, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It serves as a clock output molecule that regulates sleep through promotion of rhythmic degradation of the GABA(A) receptor. Biallelic pathogenic variants in FBXL4 are associated with an encephalopathic mtDNA maintenance defect syndrome that is a multi-system disease characterized by lactic acidemia, developmental delay, and hypotonia. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438889  Cd Length: 47  Bit Score: 37.60  E-value: 1.99e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAND----KHLEL 61
Cdd:cd22117     1 FDLLPYELIQLILSYLDLPSLCRLSQTCKLFRKHCYDpllwKELNL 46
F-box_unchar cd22139
F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 ...
 22-56 2.04e-04

F-box domain found in uncharacterized F-box protein group similar to F-box only protein 3 (FBXO3); This subfamily corresponds to a group of uncharacterized F-box proteins which show sequence similarity to F-box only protein 3 (FBXO3). FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, that mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438911  Cd Length: 45  Bit Score: 37.61  E-value: 2.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1134776224  22 DLPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22139     3 CLPDELWLHIFSFLSPKDLCQVALVCRRFNRLASD 37
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-139 3.34e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 38.17  E-value: 3.34e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1134776224  77 LMVAARSNNLEEVKKILKKGidptQTNSYHLNRTPLLAAIEGKAYQTANYLwRKYTFDPNFKD 139
Cdd:pfam12796  34 LHLAAKNGHLEIVKLLLEHA----DVNLKDNGRTALHYAARSGHLEIVKLL-LEKGADINVKD 91
F-box_FBXO15 cd22093
F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called ...
 20-56 4.04e-04

F-box domain found in F-box only protein 15 (FBXO15) and similar proteins; FBXO15, also called FBX15, has a novel dual molecular function by controlling transcriptional repression and being part of SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligases, which is essential for stress response, gliotoxin production and virulence in the opportunistic human pathogen Aspergillus fumigatus. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438865  Cd Length: 46  Bit Score: 36.85  E-value: 4.04e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22093     1 IERLPSEILLKILSYLDASSLLCISCVNKLFYQLAND 37
F-box_FBXO36 cd22106
F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called ...
 23-56 4.17e-04

F-box domain found in F-box only protein 36 (FBXO36) and similar proteins; FBXO36, also called FBX36, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438878  Cd Length: 46  Bit Score: 36.78  E-value: 4.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1134776224  23 LPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22106     4 LPDKLLLYIISYLDLEDIARLSQTSKRFKKLCNS 37
F-box_DmSKP2-like cd22149
F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and ...
 20-59 4.35e-04

F-box domain found in Drosophila melanogaster S-phase kinase-associated protein 2 (DmSKP2) and similar proteins; DmSKP2 is a Drosophila F-box protein that regulates cell proliferation by targeting Dacapo (Dap) for ubiquitination and proteasome-mediated degradation. It plays a role in maintaining diploidy of mitotic cells during development. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438920  Cd Length: 43  Bit Score: 36.58  E-value: 4.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22149     1 FERLSDEIILSIFKWLPKKTLARCARVCRRWKRLCFDESL 40
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
77-171 4.71e-04

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 39.55  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1134776224  77 LMVAARSNNLEEVKKILKKGIDPTQTNSYhlNRTPLLAAIEGKAYQTANYLwRKYTFDPNFKDNYGDSPISLLKKQLANP 156
Cdd:COG0666   190 LHLAAENGHLEIVKLLLEAGADVNAKDND--GKTALDLAAENGNLEIVKLL-LEAGADLNAKDKDGLTALLLAAAAGAAL 266

                          90
                  ....*....|....*
gi 1134776224 157 AFKDKEKKQIRALIR 171
Cdd:COG0666   267 IVKLLLLALLLLAAA 281
F-box_FBXW7 cd22133
F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, ...
 16-56 5.35e-04

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438905  Cd Length: 59  Bit Score: 36.63  E-value: 5.35e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1134776224  16 KKNFFSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22133    14 QRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAED 54
F-box_SpPof1-like cd22147
F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar ...
 19-59 7.17e-04

F-box domain found in Schizosaccharomyces pombe Skp1-binding protein 1 (SpPof1) and similar proteins; SpPof1, also called F-box/WD repeat-containing protein pof1, probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It is required for the inactivation of zip1 via ubiquitination. This subfamily also includes Saccharomyces cerevisiae methionine-requiring protein 30 (ScMET30, also called E3 ubiquitin ligase complex SCF(Met30) subunit MET30), Aspergillus niger sulfur controller B (AnSCONB, also called sulfur metabolite repression control protein B) and Neurospora crassa sulfur controller 2 (NcSCON2, also called sulfur metabolite repression control protein 2). ScMET30 acts as a transcriptional inhibitor that negatively regulates the expression of sulfur amino acid biosynthesis genes. It controls cell cycle function (being required for the G1/S transition and M-phase but not the S-phase), sulfur metabolism, and methionine biosynthesis as part of the E3 ubiquitin ligase complex SCF(Met30). AnSCONB and NcSCON2 are components of the SCF (sconB/scon-2) E3 ubiquitin ligase complexes involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438918  Cd Length: 46  Bit Score: 36.14  E-value: 7.17e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1134776224  19 FFSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22147     1 FLSALPVELSLKILSYLDAKSLCRAAQVSKKWRNLADDDEL 41
F-box_FBXO3 cd22084
F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called ...
 20-56 7.38e-04

F-box domain found in F-box only protein 3 (FBXO3) and similar proteins; FBXO3, also called FBX3, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. It also promotes ubiquitylation and transcriptional activity of AIRE (autoimmune regulator). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438856  Cd Length: 49  Bit Score: 36.08  E-value: 7.38e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22084     1 LDDLPSDPLLNILSFLDYRDLISCSQVCRRLNQLCSH 37
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 20-59 9.39e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 35.59  E-value: 9.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKL 40
F-box_FBXL2-like cd22115
F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) ...
 23-56 1.46e-03

F-box domain found in F-box/LRR-repeat protein 2 (FBXL2), F-box/LRR-repeat protein 20 (FBXL20) and similar proteins; The family includes FBXL2 and FBXL30. FBXL2, also called F-box and leucine-rich repeat protein 2, or F-box protein FBL2/FBL3, is a calcium-activated substrate-recognition component of an SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin. FBXL20, also called SCRAPPER, F-box and leucine-rich repeat protein 20, or F-box/LRR-repeat protein 2-like, is a component of a synapse-localized SCF-type E3 ubiquitin ligase which regulates neural transmission. It is widely expressed in the central nervous system and plays an important role in the ubiquitin-dependent degradation of regulating synaptic membrane exocytosis 1 (RIM1), which is an important factor in the release of synaptic vesicles. It may also mediate the ubiquitin degradation of E-cadherin resulting in an increased invasive ability of malignant cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438887  Cd Length: 45  Bit Score: 35.09  E-value: 1.46e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1134776224  23 LPEETIVNTLSFLKANTLARIAQTCQFFNRLAND 56
Cdd:cd22115     7 LPKELLLRIFSFLDVVTLCRCAQVSKYWNVLALD 40
F-box_FBXO24 cd22098
F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called ...
 20-55 2.10e-03

F-box domain found in F-box only protein 24 (FBXO24) and similar proteins; FBXO24, also called FBX24, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It recognizes deacetylated nucleoside diphosphate kinase A (NDPK-A) to enhance its degradation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438870  Cd Length: 47  Bit Score: 34.61  E-value: 2.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLAN 55
Cdd:cd22098     2 LLDLPPEILDRIISFLPVKDIVSLGQTCRYFHEVCN 37
F-box_AtSKIP31-like cd22166
F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar ...
 20-59 3.49e-03

F-box domain found in Arabidopsis thaliana SKP1-interacting partner 31 (AtSKIP31) and similar proteins; AtSKIP31, also called F-box protein SKIP31, is a component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. It interacts with SKP1A/ASK1 and SPK1B/ASK2. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438937  Cd Length: 46  Bit Score: 33.97  E-value: 3.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1134776224  20 FSDLPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22166     1 LTKLPPELFRHILKFLSPEDLTSCATVCRFLRGAASDESL 40
F-box_FBXO31 cd22102
F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called ...
 22-55 5.61e-03

F-box domain found in F-box only protein 31 (FBXO31) and similar proteins; FBXO31, also called FBX31, or FBXO14, is a component of an SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. It specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. FBXO31 may act as a tumor suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438874  Cd Length: 48  Bit Score: 33.55  E-value: 5.61e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1134776224  22 DLPEETIVNTLSFLKANTLARIAQTCQFFNRLAN 55
Cdd:cd22102     3 DLPPELLVEIFSSLPGTDLPSLAQVCKKFREILN 36
F-box_FBXW12 cd22137
F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; ...
 23-59 6.39e-03

F-box domain found in F-box/WD repeat-containing protein 12 (FBXW12) and similar proteins; FBXW12, also called F-box and WD-40 domain-containing protein 12, or F-box only protein 35 (FBXO35), is the substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It functions as an epithelial growth suppressor. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 438909  Cd Length: 44  Bit Score: 33.51  E-value: 6.39e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1134776224  23 LPEETIVNTLSFLKANTLARIAQTCQFFNRLANDKHL 59
Cdd:cd22137     3 LPDLPMLRIFSFLDAFSLLQAAQVNKQWNKVADSDYL 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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