![](files/infoQ.gif)
metallophosphoesterase family protein [Mycolicibacterium fortuitum]
metallophosphoesterase family protein( domain architecture ID 46112)
metallophosphoesterase family protein may contain an active site consisting of two metal ions (usually manganese, iron, or zinc)
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | ||||
MPP_superfamily super family | cl13995 | metallophosphatase superfamily, metallophosphatase domain; Metallophosphatases (MPPs), also ... |
3-186 | 1.52e-53 | ||||
metallophosphatase superfamily, metallophosphatase domain; Metallophosphatases (MPPs), also known as metallophosphoesterases, phosphodiesterases (PDEs), binuclear metallophosphoesterases, and dimetal-containing phosphoesterases (DMPs), represent a diverse superfamily of enzymes with a conserved domain containing an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. This superfamily includes: the phosphoprotein phosphatases (PPPs), Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. The actual alignment was detected with superfamily member cd07390: Pssm-ID: 472684 Cd Length: 170 Bit Score: 168.31 E-value: 1.52e-53
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
MPP_AQ1575 | cd07390 | Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; This family includes ... |
3-186 | 1.52e-53 | ||||
Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; This family includes bacterial and archeal proteins homologous to AQ1575, an uncharacterized Aquifex aeolicus protein. AQ1575 may play an accessory role in DNA repair, based on the close proximity of its gene to Holliday junction resolvasome genes. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277336 Cd Length: 170 Bit Score: 168.31 E-value: 1.52e-53
|
||||||||
COG4186 | COG4186 | Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily ... |
1-187 | 1.65e-44 | ||||
Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily [General function prediction only]; Pssm-ID: 443340 Cd Length: 167 Bit Score: 145.03 E-value: 1.65e-44
|
||||||||
apaH | PRK00166 | symmetrical bis(5'-nucleosyl)-tetraphosphatase; |
33-81 | 8.15e-04 | ||||
symmetrical bis(5'-nucleosyl)-tetraphosphatase; Pssm-ID: 234673 [Multi-domain] Cd Length: 275 Bit Score: 38.99 E-value: 8.15e-04
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
MPP_AQ1575 | cd07390 | Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; This family includes ... |
3-186 | 1.52e-53 | ||||
Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; This family includes bacterial and archeal proteins homologous to AQ1575, an uncharacterized Aquifex aeolicus protein. AQ1575 may play an accessory role in DNA repair, based on the close proximity of its gene to Holliday junction resolvasome genes. The domain present in members of this family belongs to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277336 Cd Length: 170 Bit Score: 168.31 E-value: 1.52e-53
|
||||||||
COG4186 | COG4186 | Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily ... |
1-187 | 1.65e-44 | ||||
Uncharacterized conserved protein MJ1445, calcineurin-like phosphoesterase superfamily [General function prediction only]; Pssm-ID: 443340 Cd Length: 167 Bit Score: 145.03 E-value: 1.65e-44
|
||||||||
CpdA | COG1409 | 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; |
7-99 | 2.39e-06 | ||||
3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]; Pssm-ID: 441019 [Multi-domain] Cd Length: 234 Bit Score: 46.22 E-value: 2.39e-06
|
||||||||
MPP_GpdQ | cd07402 | Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; GpdQ ... |
7-96 | 3.30e-06 | ||||
Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; GpdQ (glycerophosphodiesterase Q, also known as Rv0805 in Mycobacterium tuberculosis) is a binuclear metallophosphoesterase from Enterobacter aerogenes that catalyzes the hydrolysis of mono-, di-, and triester substrates, including some organophosphate pesticides and products of the degradation of nerve agents. The GpdQ homolog, Rv0805, has 2',3'-cyclic nucleotide phosphodiesterase activity. GpdQ and Rv0805 belong to the metallophosphatase (MPP) superfamily. MPPs are functionally diverse, but all share a conserved domain with an active site consisting of two metal ions (usually manganese, iron, or zinc) coordinated with octahedral geometry by a cage of histidine, aspartate, and asparagine residues. The MPP superfamily includes: Mre11/SbcD-like exonucleases, Dbr1-like RNA lariat debranching enzymes, YfcE-like phosphodiesterases, purple acid phosphatases (PAPs), YbbF-like UDP-2,3-diacylglucosamine hydrolases, and acid sphingomyelinases (ASMases). The conserved domain is a double beta-sheet sandwich with a di-metal active site made up of residues located at the C-terminal side of the sheets. This domain is thought to allow for productive metal coordination. Pssm-ID: 277347 [Multi-domain] Cd Length: 240 Bit Score: 45.73 E-value: 3.30e-06
|
||||||||
YfcE | COG0622 | Predicted phosphodiesterase, calcineurin family [General function prediction only]; |
43-154 | 2.47e-04 | ||||
Predicted phosphodiesterase, calcineurin family [General function prediction only]; Pssm-ID: 440387 [Multi-domain] Cd Length: 183 Bit Score: 39.90 E-value: 2.47e-04
|
||||||||
apaH | PRK00166 | symmetrical bis(5'-nucleosyl)-tetraphosphatase; |
33-81 | 8.15e-04 | ||||
symmetrical bis(5'-nucleosyl)-tetraphosphatase; Pssm-ID: 234673 [Multi-domain] Cd Length: 275 Bit Score: 38.99 E-value: 8.15e-04
|
||||||||
COG2129 | COG2129 | Predicted phosphoesterase, related to the Icc protein [General function prediction only]; |
4-82 | 1.35e-03 | ||||
Predicted phosphoesterase, related to the Icc protein [General function prediction only]; Pssm-ID: 441732 [Multi-domain] Cd Length: 211 Bit Score: 38.07 E-value: 1.35e-03
|
||||||||
Blast search parameters | ||||
|