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Conserved domains on  [gi|1133684106|ref|WP_076069929|]
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BrnA antitoxin family protein [Sphingomonas montana]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BrnA_antitoxin super family cl46336
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 1-76 4.25e-12

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


The actual alignment was detected with superfamily member COG3514:

Pssm-ID: 480676  Cd Length: 91  Bit Score: 55.82  E-value: 4.25e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133684106  1 MSEEKPDTPIEWD--DAPEWSDEMFDRAEISVGGKvirpatgtltragrsPLGTAAKQQVTLQLDPDVVEKFRADKPG 76
Cdd:COG3514   15 EEDEEITAAAAIDpsDAPELTDEFFARARKRRRGR---------------PKAAPPKVQVTIRLDPDVLEWFKATGPG 77
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
1-76 4.25e-12

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 55.82  E-value: 4.25e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133684106  1 MSEEKPDTPIEWD--DAPEWSDEMFDRAEISVGGKvirpatgtltragrsPLGTAAKQQVTLQLDPDVVEKFRADKPG 76
Cdd:COG3514   15 EEDEEITAAAAIDpsDAPELTDEFFARARKRRRGR---------------PKAAPPKVQVTIRLDPDVLEWFKATGPG 77
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 14-76 4.93e-09

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 47.29  E-value: 4.93e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133684106 14 DAPEWSDEMFDRAEisvggkviRPATGTLTRaGRSPLGTAAKQQVTLQLDPDVVEKFRADKPG 76
Cdd:pfam14384  1 DAPELTDEQWLARA--------RPAKEALPR-GRPRRPLPPKKAVTIRLDADVLEAFKATGKG 54
 
Name Accession Description Interval E-value
COG3514 COG3514
Uncharacterized conserved protein, DUF4415 family [Function unknown];
1-76 4.25e-12

Uncharacterized conserved protein, DUF4415 family [Function unknown];


Pssm-ID: 442736  Cd Length: 91  Bit Score: 55.82  E-value: 4.25e-12
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1133684106  1 MSEEKPDTPIEWD--DAPEWSDEMFDRAEISVGGKvirpatgtltragrsPLGTAAKQQVTLQLDPDVVEKFRADKPG 76
Cdd:COG3514   15 EEDEEITAAAAIDpsDAPELTDEFFARARKRRRGR---------------PKAAPPKVQVTIRLDPDVLEWFKATGPG 77
BrnA_antitoxin pfam14384
BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that ...
 14-76 4.93e-09

BrnA antitoxin of type II toxin-antitoxin system; BrnA is family of antitoxins that neutralizes the toxin BrnT, pfam04365. It consists of 3 alpha-helices and a C-terminal ribbon-helix-helix DNA binding domain. As in other toxin-antitoxin systems, BrnA negatively autoregulates the brnTA operon and has higher affinity for the DNA operator when complexed with BrnT. It dimerizes with two molecules of its toxin BrnT.


Pssm-ID: 433924  Cd Length: 67  Bit Score: 47.29  E-value: 4.93e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1133684106 14 DAPEWSDEMFDRAEisvggkviRPATGTLTRaGRSPLGTAAKQQVTLQLDPDVVEKFRADKPG 76
Cdd:pfam14384  1 DAPELTDEQWLARA--------RPAKEALPR-GRPRRPLPPKKAVTIRLDADVLEAFKATGKG 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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