|
Name |
Accession |
Description |
Interval |
E-value |
| PQQ_enz_alc_DH |
TIGR03075 |
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic ... |
25-556 |
0e+00 |
|
PQQ-dependent dehydrogenase, methanol/ethanol family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see pfam01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.
Pssm-ID: 274419 [Multi-domain] Cd Length: 527 Bit Score: 884.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 25 ALAGVTDQDILQDPKNPGQIVTNGLGVQGQRYSPLDTLNVNNVKDLRPVWAFSFGgeKQRGQQAQPMIKDGVMYLTGSYS 104
Cdd:TIGR03075 2 AAAAVTNEDLLNDAKDPSDWLTYGGGYAGQRYSPLDQINTDNVKKLQPAWTFSLG--KQRGQESQPLVVDGVMYVTTSYS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 105 RVFAVDARTGKKLWQYDARLPDDIRP--CCDVINRGVALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISA 182
Cdd:TIGR03075 80 RVYALDAKTGKILWKYDPKLPDDIIPvmCCDVVNRGAALYDGKVFFGTLDARLVALDAKTGKVVWSKKNGDYKKGYTITA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 183 APLVINGKLITGVAGGEFGVVGKIEAYDPKNGSLLWSRPTVEGHMGYTYKDGKAVengiSGGEAGKTWPGDLWKTGGAAP 262
Cdd:TIGR03075 160 APLVVKGKVITGISGGEFGVRGYVTAYDAKTGKLVWRRYTVPGDMGYLKKTGKPV----GGDPGAKTWPGDAWKTGGGAT 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 263 WLGGYYDPETNLLLFGTGNPAPWNSHLRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEI 342
Cdd:TIGR03075 236 WGTGSYDPETNLIYFGTGNPAPWNSHLRPGDNLYTSSIVARDPDTGKIKWHYQTTPHDEWDYDGVNEMILFDLKKDGKPR 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 343 KAAATADRNGFFYVLDRTNGKFIRGFPFVDKITWATGLD-KEGRPIYNEASRPGApgtEAKGSSVFVAPAFLGAKNWMPM 421
Cdd:TIGR03075 316 KLLAHADRNGFFYVLDRTNGKLLSAEPFVDKVNWATGVDlKTGRPIEVPEARSTD---GKKGKPVEVCPGFLGGKNWQPM 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 422 AYNKDTGLFYVPSNEWGMDIWNEGIAYKKGAAFLGAGFTIKPLNEDYIGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKG 501
Cdd:TIGR03075 393 AYSPKTGLFYVPANHVCMDYWPEKVSYKKGAAYLGAGFTIKPPPDDHIGSLIAWDPITGKIVWEHKEDFPLWGGVLATAG 472
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*
gi 1132400695 502 KLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGG 556
Cdd:TIGR03075 473 DLVFTGTLEGYFKAFDAKTGEELWKFKTGSGIVGPPVTYEQDGKQYVAVLSGWGG 527
|
|
| PQQ_ADH_I |
cd10277 |
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); ... |
34-583 |
0e+00 |
|
Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); This bacterial family of homodimeric ethanol dehydrogenases utilize pyrroloquinoline quinone (PQQ) as a cofactor. It represents proteins whose expression may be induced by ethanol, and which are similar to quinoprotein methanol dehydrogenases, but have higher specificities for ethanol and other primary and secondary alcohols. Dehydrogenases with PQQ cofactors, such as ethanol, methanol, and membrane-bound glucose dehydrogenases, form an 8-bladed beta-propeller.
Pssm-ID: 199835 [Multi-domain] Cd Length: 529 Bit Score: 875.09 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 34 ILQDPKNPGQIVTNGLGVQGQRYSPLDTLNVNNVKDLRPVWAFSFGGeKQRGQQAQPMIKDGVMYLTGSYSRVFAVDART 113
Cdd:cd10277 1 LLNDAKETGNWLTYGRGYNGQRYSPLKQINTDNVKNLVPAWSFSFGG-KQRGQESQPIVNDGVMYVTTSYNRVFAIDAKT 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 114 GKKLWQYDARLPDDIRPCCDVINRGVALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISAAPLVINGKLIT 193
Cdd:cd10277 80 GKELWKYKHRLPEDIRPCCDVVNRGVALYGDKVYFGTLDAHLVALDAKTGKVVWKKKVADYKAGYSMTLAPLVVKGKVIV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 194 GVAGGEFGVVGKIEAYDPKNGSLLWSRPTVEGHMGYTYkdgkavengisggeaGKTWPGDLWKTGGAAPWLGGYYDPETN 273
Cdd:cd10277 160 GVSGGEFGVRGFIAALDAETGKEVWRTYTVPGPGEPGS---------------TDTWPGDAWKTGGGATWLTGTYDPETN 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 274 LLLFGTGNPAPWNSHLRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEIKAAATADRNGF 353
Cdd:cd10277 225 LLYWGVGNPAPWNGDLRPGDNLYTSSVLALDPDTGKIKWHYQYTPNDTWDYDGVNEPVLFDYTKNGKPVKALVHADRNGF 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 354 FYVLDRTNGKFIRGFPFVDKITWATGLDKEGRPIYNEASRPGApgteaKGSSVFVAPAFLGAKNWMPMAYNKDTGLFYVP 433
Cdd:cd10277 305 FYVLDRTNGKLIWATPFVKKITWASIDLKTGRPIYDEDKVPPK-----KGKTVDFCPSFLGGKNWPPMAYSPDTGLFYVP 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 434 SNEWGMDIWNEGIAYKKGAAFLGAGFTIKPLNEDYIGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKGKLVFTGTPEGFL 513
Cdd:cd10277 380 ANHWCMDLTGEPVSYKKGAAYLGAGFTIKPPFEDHIGELQAIDPTTGKKVWEHKTPLPLWGGVLTTAGGLVFTGTPDGYF 459
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 514 QAFNAKTGEKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGGAVPLWGGEVAKRIKDFNQGGMLWTFKL 583
Cdd:cd10277 460 RAFDAKTGKELWEFQTGSGIIGPPVTWEVDGKQYVAVLSGWGGAAPLWGGDMAKLLKNVPQGGSLWVFAL 529
|
|
| Gcd |
COG4993 |
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism]; |
40-584 |
0e+00 |
|
Glucose dehydrogenase, PQQ-dependent [Carbohydrate transport and metabolism];
Pssm-ID: 444017 [Multi-domain] Cd Length: 515 Bit Score: 715.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 40 NPGQIVTNGLGVQGQRYSPLDTLNVNNVKDLRPVWAFSFGGEKQRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQ 119
Cdd:COG4993 1 DPGDWLAYGGDYAGQRYSPLDQINPDNVKKLKVAWTFSTGDLPERGHEATPLVVDGVLYVCTPHNRVFALDAATGKELWR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 120 YDARLPDDIrPCCDVINRGVALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISAAPLVINGKLITGVAGGE 199
Cdd:COG4993 81 YDPKLPDDA-ACCDVVNRGVAYYDGRIFLGTLDGRLVALDAKTGKVCWDVKVGDPKKGYTITSAPLVVKDKVIVGGSGGE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 200 FGVVGKIEAYDPKNGSLLWSRPTVEGHmgytykdgkavengisGGEAGKTWP-GDLWKTGGAAPWLGGYYDPETNLLLFG 278
Cdd:COG4993 160 FGPRGVVRAYDARTGKLVWRFDTIPDP----------------GEPGAETWPpGDTWKRGGGNVWGTMSYDPELGLVYLP 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 279 TGNPAP-WNSHLRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEIKAAATADRNGFFYVL 357
Cdd:COG4993 224 TGNPAPdWNGGQRPGDNLYSSSIVALDADTGELKWHYQTVPHDLWDYDGPNEPILVDLPVDGKTRKALVQATKNGFIYVL 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 358 DRTNGKFIRGFPFVDKITWATGLDKEGR-PIYNEASrpgapgteAKGSSVFVAPAFLGAKNWMPMAYNKDTGLFYVPSNE 436
Cdd:COG4993 304 DRETGEPLVTQPFVKPPNWATEIDMWGAtPIQTPPS--------LDGKTTLICPGALGGKNWGPAAYDPETGLLYVPANE 375
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 437 WGMDIWNEGIAYKKGAAFLGAGFTIKPLNEDYIGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKGKLVFTGTPEGFLQAF 516
Cdd:COG4993 376 LCMDYELVPREYQAGAPYLGATLTMYPCPAPPWGTLTAIDLNTGKIVWQVPLGFPNWGGPLATAGGLVFIGTLDGYLRAF 455
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1132400695 517 NAKTGEKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGGAVPLWGgevakrikDFNQGGMLWTFKLP 584
Cdd:COG4993 456 DAKTGKELWKFRLPSGGQATPMTYEVDGKQYVAVAAGGGGWLGLGL--------YTPQGDYLIAFALP 515
|
|
| PQQ_ADH_II |
cd10279 |
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of ... |
48-583 |
1.61e-178 |
|
PQQ_like domain of the quinohemoprotein alcohol dehydrogenase (type II); This family of monomeric and soluble type II alcohol dehydrogenases utilizes pyrroloquinoline quinone (PQQ) as a cofactor and is related to ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller.
Pssm-ID: 199837 [Multi-domain] Cd Length: 549 Bit Score: 516.04 E-value: 1.61e-178
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 48 GLGVQGQRYSPLDTLNVNNVKDLRPVWAFSFGGEkqRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDD 127
Cdd:cd10279 7 GRDYDEQRFSPLTQINRSNVGQLGLAWYFDLDTN--RGQEATPLVVDGVMYVSGPWSVVYALDARTGKLLWQYDPEVDRE 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 128 I--RPCCDVINRGVALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISAAPLVINGKLITGVAGGEFGVVGK 205
Cdd:cd10279 85 SgrKACCDVVNRGVAVWDGKVFVGTLDGRLIALDAKTGKEVWSVDTIDPRKPYTITGAPRVAKGKVVIGNGGAEFGVRGY 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 206 IEAYDPKNGSLLWSRPTVEGHMGYTYkdgkavENGISGGEAGKTWPGDLWKTG-GAAPWLGGYYDPETNLLLFGTGNPAP 284
Cdd:cd10279 165 VSAYDAETGKLVWRFYTVPGNPAKPF------EHASLEAAAATWWTGEWWRTGgGGTVWDSITYDPELDLLYIGTGNGSP 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 285 WNSHLRP---GDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEIKAAATADRNGFFYVLDRTN 361
Cdd:cd10279 239 WNRKVRSpggGDNLFLSSIVALDADTGRYKWHYQTTPGDTWDYTATQPIILADLEIDGKPRKVLMHAPKNGFFYVLDRAT 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 362 GKFIRGFPFVDkITWATGLD-KEGRPIYNEASRPGApgteakgSSVFVAPAFLGAKNWMPMAYNKDTGLFYVPSNEWGMD 440
Cdd:cd10279 319 GKLLSAEPFVP-VNWATGIDlKTGRPIENPEARYTK-------GPKLVFPGPLGAHNWHPMSYNPDTGLVYIPAQEIPAV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 441 IWNEGIAYKKGAAFLGAGFT----------IKPLNEDYIGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKGKLVFTGTPE 510
Cdd:cd10279 391 YEDDPGDFGYNPLGWNTGITpdatpppaaaKRALRKATRGRLVAWDPVTQKAAWRVEHPGPWNGGVLATAGNLVFQGTAD 470
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 511 GFLQAFNAKTGEKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGGAVPLWGGEVAKRIKDFNQGGMLwTFKL 583
Cdd:cd10279 471 GELAAYDARTGEKLWSFDTGSGIVAAPMTYSVDGEQYVAVLAGWGGAGALSGGPPGAAGKVQNPGRLL-VFKL 542
|
|
| PQQ_MDH |
cd10278 |
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the ... |
52-583 |
2.95e-166 |
|
Large subunit of methanol dehydrogenase (moxF); Methanol dehydrogenase is a key enzyme in the utilization of C1 compounds as a source of energy and carbon by bacteria. It catalyzes the oxidation of methanol to formaldehyde, transfering two electrons per methanol to cytochrome c(L) as the acceptor. Methanol dehydrogenase belongs to a family of dehydrogenases with pyrroloquinoline quinone (PQQ) as cofactor, which also includes dehydrogenases specific to other alcohols and membrane-bound glucose dehydrogenases. This alignment model for the large subunit contains an 8-bladed beta-propeller; the functional enzyme forms a heterotetramer composed of two large and two small subunits.
Pssm-ID: 199836 [Multi-domain] Cd Length: 553 Bit Score: 484.91 E-value: 2.95e-166
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 52 QGQRYSPLDTLNVNNVKDLRPVWAFSFGgeKQRGQQAQPMIKDGVMYLTGSY-SRVFAVD-ARTGKKLWQYDARLPDDIR 129
Cdd:cd10278 9 ANTRYSPLAQINKDNVKNLKVAWTFSTG--VLRGHEGAPLVVGDTMYVVTPFpNNVYALDlNDPGKILWKYKPKQDPSAV 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 130 P--CCDVINRGVAlYGD-LVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISAAPLVINGKLITGVAGGEFGVVGKI 206
Cdd:cd10278 87 AvaCCDVVNRGLA-YADgKIFFNQLDGHLVALDAKTGKEVWKVKNGDPKVGETLTMAPLVVKDKVIVGISGGEFGVRGYV 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 207 EAYDPKNGSLLWsRPTVEG---HMGYTYKDGKAVENGISGGEAGKTWPGDLWKTGGAAPWlGGY-YDPETNLLLFGTGNP 282
Cdd:cd10278 166 TAYDLKTGKLVW-RAYSTGpdkDVLIGPDFNPFNPHDGGKDLGLSTWPGDAWKIGGGTNW-GWYsYDPKLNLVYYGTGNP 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 283 APWNSHLRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEIKAAATADRNGFFYVLDRTNG 362
Cdd:cd10278 244 GPWNPTQRPGDNKWSMTIFARDPDTGEAKWAYQMTPHDEWDYDGVNEMILVDQTVDGKKRKLLVHFDRNGFVYTLDRTTG 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 363 KFIRGFPFVDkITWATGLD-KEGRPIYNEASRPGAPGTeAKGssvfVAPAFLGAKNWMPMAYNKDTGLFYVPSNEWGMDI 441
Cdd:cd10278 324 ELLSAEKFDP-VNNWKGVDlKTGRPVKDPEKSTHMDHN-VTD----ICPSAMGGKDQQPSSYSPKTGLFYVPTNHLCMDY 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 442 WNEGIAYKKGAAFLGAGFTIKPLNEDYIGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKGKLVFTGTPEGFLQAFNAKTG 521
Cdd:cd10278 398 EPFEVNYTAGQPYVGATLAMYPGPGGHMGQFKAWDPVTGKTKWEIKERFPVWSGTLATAGGLVFYGTLDGWFKAVDAKTG 477
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1132400695 522 EKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGG--AVPLWGGEV-----------AKRIKDF-NQGGMLWTFKL 583
Cdd:cd10278 478 KLLWKFKLPSGIIGNPITYKHDGKQYVAVLSGVGGwaGVGVAAGLRdptaglgavgaFKDLPNYtQMGGTLYVFSL 553
|
|
| PQQ_DH_like |
cd00216 |
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ... |
64-582 |
6.26e-151 |
|
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.
Pssm-ID: 199833 [Multi-domain] Cd Length: 434 Bit Score: 441.28 E-value: 6.26e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 64 VNNVKDLRPVWAFSFGGEKQRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDD-IRPCCDVINRGVALY 142
Cdd:cd00216 1 ADNVFQLTPAWSFSTGDGGNRGSELTPIVVDGVMYATTSFSRVFALDADDGKEIWSYDPALKDGwFEACCDLVNRGVAVW 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 143 GDLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSISAAPLVINGKLITGVAGGEFGVVGKIEAYDPKNGSLLWSRPT 222
Cdd:cd00216 81 GGKVYIGVLDGRVYALNAETGKVAWKVKNADVLGGYTATSAPVVVDGLVIIGSSGDEFGVRGYLTAYDVATGEEKWRFYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 223 VEGHMGYTYKDGKAVENGISGgeagkTWPGDLWKTGGAAPWLGGYYDPETNLLLFGTGNPAPWN--SHLRPGDNLYSSSR 300
Cdd:cd00216 161 VMPDPNLLPGKDSTVTDRNTP-----TGDEHTWTSGGGTGWSSAAYDAELNLIYVGGGNPTPWNwgGNRTPGDNLYTSSI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 301 LALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKEIKAAATADRNGFFYVLDRTNGKFIRGFPFVdkitwatgl 380
Cdd:cd00216 236 VAVNADTGEMKWQYQTTPHDAWDYDGDNTPVLADIKVKGKKVKVLFAPAKNGNFYVLDRRNGELVSARPLV--------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 381 dkegrpiyneasrpgapgteakgssvfvapaflgaknwmPMAYNKDTGLFYVPSNewgmdiwnegiaykkgaaflgagft 460
Cdd:cd00216 307 ---------------------------------------PDSYDPDRELFYVPAN------------------------- 322
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 461 ikplnedyiGVLRAIDPKTGKEVWRHKNFAPLWGGVLTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTW 540
Cdd:cd00216 323 ---------GRIMALDPVTGVVVWEKSELHPLLGGPLSTAGNLVFVGTSDGYLKAYNADTGEKLWQQKVPSGFQAEPVTY 393
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 1132400695 541 EMDGEQYVSVLSGWGGAVPLWGGeVAKRIKDFNQGGMLWTFK 582
Cdd:cd00216 394 EVDGEQYVLIQAGGGGAFPLWGG-MADLTRGTQMGGTVVVYK 434
|
|
| PQQ_mGDH |
cd10280 |
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes ... |
53-556 |
4.27e-80 |
|
Membrane-bound PQQ-dependent glucose dehydrogenase; This bacterial subfamily of enzymes belongs to the dehydrogenase family with pyrroloquinoline quinone (PQQ) as cofactor, and is the only subfamily that is bound to the membrane. Glucose dehydrogenase converts D-glucose to D-glucono-1,5-lactone in a reaction that is coupled with the respiratory chain in the periplasmic oxidation of sugars and alcohols in gram-negative bacteria. Ubiquinone functions as the electron acceptor. The alignment model contains an 8-bladed beta-propeller.
Pssm-ID: 199838 [Multi-domain] Cd Length: 616 Bit Score: 264.05 E-value: 4.27e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 53 GQRYSPLDTLNVNNVKDLRPVWAFSFGGEKQRGQ-----QAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDD 127
Cdd:cd10280 10 GTRYSPLDQITPDNVGKLKVAWTYHTGDLPGPDGnegtfEATPLKVGGTLYLCTPHNRVIALDAATGKELWRFDPKAGAD 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 128 iRPCCDVINRGVALYGD---------LVIFGTLDAKLVALNKDTGKVVWS---KKVADHKEG--------YSISAAPLVI 187
Cdd:cd10280 90 -AAPGHQTCRGVSYWEDgaaaaacarRIFFGTGDARLIALDARTGKPCPDfgdNGVVDLREGlgrvkpgfYSSTSPPTVY 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 188 NGKLITGVAGGEFGVV----GKIEAYDPKNGSLLWsrptveghmgytykdgkAVENGISGGEAGKTWPGDLWKTGGAAPW 263
Cdd:cd10280 169 GDLVIVGSAVADNQAVdapsGVIRAFDVRTGKLVW-----------------AFDTIPPPGEAGPDTAGAWYTRGGPNVW 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 264 LGGYYDPETNLLLFGTGNPAP--WNSHlRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYDGVNELVSFNYTEGGKE 341
Cdd:cd10280 232 AGMSADEKLGLVYLPTGSATPdfYGGD-RPGDNLFANSLVALDAATGKRRWHFQTVHHDLWDYDLPAQPTLVDVPRDGKT 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 342 IKAAATADRNGFFYVLDRTNGKFIRG--------------------------FPF------VDKITWATGLDKEGRPIYN 389
Cdd:cd10280 311 VPAVAQPTKQGFVFVLDRRTGKPLWPveerpvpqgdvpgertsptqpfptlpPPFarqgltEDDMWGATPFDQLACRIQF 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 390 EASRPGAPGT--EAKGSSVFvaPAFLGAKNWMPMAYNKDTGLFYVPSNEWGMDIW-----NEGIAYKKGAAFLGAGFTIK 462
Cdd:cd10280 391 RSLRYEGLFTppSLDGTLIF--PGNDGGANWGGAAVDPERGILYVNSNRLPFVIQlvpraPGDPAGVAGGGEGGGGGGGP 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 463 PLNEDYI---------------------GVLRAIDPKTGKEVWRHKN-----------------FAPLWGGVLTTKGKLV 504
Cdd:cd10280 469 SPQAGTPygvgrgrflsplglpcqappwGTLTAIDLNTGKILWQVPLgtvpdlgpkgiplpiptGTPNLGGPVVTAGGLV 548
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 505 FTG-TPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTWEMDGEQYVSVLSGWGG 556
Cdd:cd10280 549 FIAaTQDNYLRAFDKATGKELWEARLPAGGQATPMTYEVDGKQYVVIAAGGHG 601
|
|
| PQQ_membr_DH |
TIGR03074 |
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein ... |
4-553 |
1.34e-48 |
|
membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; This protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Members of this family have several predicted transmembrane helices in the N-terminal region, and include the quinoprotein glucose dehydrogenase (EC 1.1.5.2) of Escherichia coli and the quinate/shikimate dehydrogenase of Acinetobacter sp. ADP1 (EC 1.1.99.25). Sequences closely related except for the absense of the N-terminal hydrophobic region, scoring in the gray zone between the trusted and noise cutoffs, include PQQ-dependent glycerol (EC 1.1.99.22) and and other polyol (sugar alcohol) dehydrogenases.
Pssm-ID: 274418 [Multi-domain] Cd Length: 764 Bit Score: 180.97 E-value: 1.34e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 4 PARRQPFVLSVLLSAMLLSGSALAGVTDQDILQDPKNPGQIVTNGLGVQ-------------GQRYSPLDTLNVNNVKDL 70
Cdd:TIGR03074 85 PARRGAGALAGVLAVAVLAALASMFTDPHPIVGALDTEVPATAAAAPAVpagdwaaygrtqaGQRYSPLDQINPDNVGNL 164
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 71 RPVWAFSFGGEKQRGQ------QAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDDIRP----CcdvinRGVA 140
Cdd:TIGR03074 165 KVAWTYHTGDLKTPDDpgeatfQATPLKVGDTLYLCTPHNKVIALDAATGKEKWKFDPKLKTEADRqhqtC-----RGVS 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 141 LYGD------------------LVIFGTLDAKLVALNKDTGKVVWS---KKVADHKEG--------YSISAAPLVINGKL 191
Cdd:TIGR03074 240 YYDApaaaagpagpaapadcarRIILPTSDARLIALDADTGKLCEDfgnNGTVDLTAGmgptppgyYYPTSPPLVAGTTV 319
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 192 ITG------VAGGEFGvvGKIEAYDPKNGSLLWSrptveghmgytYKDGKAVENGISGgeagktwPGDLWKTGGAAPWLG 265
Cdd:TIGR03074 320 VIGgrvadnYSTDEPS--GVIRAFDVNTGALVWA-----------WDPGNPDPTAPPA-------PGETYTRNSPNSWSV 379
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 266 GYYDPETNLLLFGTGNPAP--WNSHLRPGDNLYSSSRLALNPDDGTIKWHFQSTPHDGWDYD--GVNELVSFNyTEGGKE 341
Cdd:TIGR03074 380 ASYDEKLGLVYLPMGNQTPdqWGGDRTPADEKYSSSLVALDATTGKERWVFQTVHHDLWDMDvpAQPSLVDLP-KADGTT 458
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 342 IKAAATADRNGFFYVLDRTNGKFI-----------------------------RGFPFVDKITW-ATGLDKEG-RPIYNE 390
Cdd:TIGR03074 459 VPALVAPTKQGQIYVLDRRTGEPIvpveevpvpqgavpgerysptqpfsvltfGPPTLTESDMWgATPFDQLAcRIQFKS 538
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 391 ASRPG---APGTEakGSSVFvaPAFLGAKNWMPMAYNKDTGLFYVPSN--------------EWGMDIWN-----EGIAY 448
Cdd:TIGR03074 539 LRYEGlytPPSEQ--GSLVF--PGNLGGFNWGGVAVDPTRQVMFVNPMrlpfvsqlvprapgDEAPSGAKgkgteMGLNP 614
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 449 KKGA-------AFLGAgFTIkPLNEDYIGVLRAIDPKTGKEVWRHKNFA-------------------PLWGGVLTTKGK 502
Cdd:TIGR03074 615 NKGTpyavnmnPFLSP-LGI-PCQAPPWGYMAAIDLKTGKVVWQHPNGTvrdtgpmgipmplpipigvPTLGGPLATAGG 692
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 503 LVF-TGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTW-EMDGEQYVSVLSG 553
Cdd:TIGR03074 693 LVFiGATQDNYLRAYDLSTGKELWEARLPAGGQATPMTYmGKDGKQYVVIVAG 745
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
64-219 |
2.08e-18 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 87.18 E-value: 2.08e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 64 VNNVKDLRPVWAFSFG-GEKQRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccdvINRGVALY 142
Cdd:COG1520 26 FEPSVKVKQLWSASVGdGVGKGYSRLAPAVAGDRVYAADADGRVAALDAATGKELWRVDLGEP---------LSGGVGAD 96
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1132400695 143 GDLVIFGTLDAKLVALNKDTGKVVWSKKVADhkegySISAAPLVINGKLItgVAGGEfgvvGKIEAYDPKNGSLLWS 219
Cdd:COG1520 97 GGLVVVGTEDGEVIALDADDGEELWRARLSS-----EVLAAPAVAGGRVV--VRTGD----GRVYALDAATGERLWS 162
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
90-228 |
1.02e-14 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 73.98 E-value: 1.02e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 90 PMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPD-DIRPccdviNRGVALYGDLVIFGTLDAKLVALNKDTGKVVWS 168
Cdd:pfam13360 69 PLVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSGEPlALRS-----SGSPAVVGDTVVAGFSSGKLVALDPATGKVRWE 143
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1132400695 169 KKVADHKEGYSIS-----AAPLVINGKLITGVAGGefgvvGKIEAYDPKNGSLLWSRPtVEGHMG 228
Cdd:pfam13360 144 APLAAPRGTNELErlvdiTGTPVVAGGRVFASAYQ-----GRLVAFDAATGRRLWTRE-ISGPNG 202
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
69-219 |
1.84e-12 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 69.19 E-value: 1.84e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 69 DLRPVWAFSFG-GEKQRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccdvINRGVALYGDLVI 147
Cdd:TIGR03300 39 KVDQVWSASVGdGVGHYYLRLQPAVAGGKVYAADADGTVAALDAETGKRLWRVDLDER---------LSGGVGADGGLVF 109
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1132400695 148 FGTLDAKLVALNKDTGKVVWSKKVADhkegySISAAPLVINGKLITGVAGgefgvvGKIEAYDPKNGSLLWS 219
Cdd:TIGR03300 110 VGTEKGEVIALDAEDGKELWRAKLSS-----EVLSPPLVANGLVVVRTND------GRLTALDAATGERLWT 170
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
88-221 |
1.23e-11 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 66.49 E-value: 1.23e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 88 AQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccdVIN-RGVA---LYGDLVIFGTLDAKLVALNKDTG 163
Cdd:TIGR03300 139 SPPLVANGLVVVRTNDGRLTALDAATGERLWTYSRVTP--------PLTlRGSAspvIADGGVLVGFAGGKLVALDLQTG 210
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1132400695 164 KVVWSKKVADHKeGYS-------ISAAPLVINGKLitgvaggeFGVV--GKIEAYDPKNGSLLWSRP 221
Cdd:TIGR03300 211 QPLWEQRVALPK-GRTelerlvdVDGDPVVDGGQV--------YAVSyqGRVAALDLRSGRVLWKRD 268
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
74-365 |
1.68e-11 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 65.82 E-value: 1.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 74 WAFSFGGEKQRGQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDArlpddirPCCDVINRGVALYGDLVIFGTLDA 153
Cdd:cd10276 18 WSKSVGNGGMAGIDLTPVVAGDMVYAADANGQVSAFNATTGKIIWETSL-------SGKGFLGGTPAVGNGKIFVGTESG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 154 KLVALNKDTGKVVWSKKVADHkegySISAAPLVINGKLITGVAGGEFgvvgkiEAYDPKNGSLLWSRptveghmgytykd 233
Cdd:cd10276 91 YLYALDAKDGSELWRTEVSDS----QLLSPPTYADGKIYVGTGDGRL------YYCNAETGKVVWNR------------- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 234 gkavENGISGGEagktwpgdLWktgGAAPWLGGYYDpetnllLFGTGNpapwNSHLrpgdnlysssrLALNPDDGTIKWH 313
Cdd:cd10276 148 ----TSTAPELS--------LR---GGAAPVGAYDV------VFVGDG----NGTV-----------VALNTGTGVDIWE 191
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 314 FQST-PHDGWDYDGVNElVSFNYTEGGKEIKAAATadrNGFFYVLDRTNGKFI 365
Cdd:cd10276 192 FSVSePRGRTELPRMID-SSVTYVVVGGYLYSTSY---QGYLVALDFESGQFL 240
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
467-539 |
2.58e-11 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 65.72 E-value: 2.58e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 467 DYIGVLRAIDPKTGKEVWRHKNFAPLWGGVlTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVT 539
Cdd:TIGR03300 72 DADGTVAALDAETGKRLWRVDLDERLSGGV-GADGGLVFVGTEKGEVIALDAEDGKELWRAKLSSEVLSPPLV 143
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
88-221 |
3.53e-11 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 65.22 E-value: 3.53e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 88 AQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccdVIN-RG---VALYGDLVIFGTLDAKLVALNKDTG 163
Cdd:COG1520 131 AAPAVAGGRVVVRTGDGRVYALDAATGERLWSYQRPVP--------ALTlRGtssPVIVGGAVLVGFANGKLVALDLANG 202
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1132400695 164 KVVWSKKVADHKeGYS-------ISAAPLVINGKLitgvaggeFGVV--GKIEAYDPKNGSLLWSRP 221
Cdd:COG1520 203 QPLWEQRVAQPR-GRTelerlvdVDGTPVVDGGVV--------YAVAyqGRLAALDLRSGRVLWSRD 260
|
|
| PRK11138 |
PRK11138 |
outer membrane biogenesis protein BamB; Provisional |
11-219 |
5.05e-11 |
|
outer membrane biogenesis protein BamB; Provisional
Pssm-ID: 236857 [Multi-domain] Cd Length: 394 Bit Score: 64.95 E-value: 5.05e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 11 VLSVLLSAMLLSGSALAGvTDQDILqdPKNPGQIVTN------------GLGVqGQRYSpldtlnvnnvkDLRPVWAfsf 78
Cdd:PRK11138 7 LLPGLLSVTLLSGCSSFN-SEEDVV--KMSPLPQVENqftpttvwstsvGDGV-GDYYS-----------RLHPAVA--- 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 79 ggekqrgqqaqpmikDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDDIRPCCD--VINRGVALYGDLVIFGTLDAKLV 156
Cdd:PRK11138 69 ---------------YNKVYAADRAGLVKALDADTGKEIWSVDLSEKDGWFSKNKsaLLSGGVTVAGGKVYIGSEKGQVY 133
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 157 ALNKDTGKVVWSKKVAdhkeGYSISaAPLVINGKLITGVAGgefgvvGKIEAYDPKNGSLLWS 219
Cdd:PRK11138 134 ALNAEDGEVAWQTKVA----GEALS-RPVVSDGLVLVHTSN------GMLQALNESDGAVKWT 185
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
104-219 |
5.40e-11 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 62.81 E-value: 5.40e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 104 SRVFAVDARTGKKLWQYDARLPddirpccdvINRGVALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVADhkegySISAA 183
Cdd:pfam13360 3 GVVTALDAATGAELWRVDLETG---------LGGGVAVDGGRLFVATGGGQLVALDAATGKLLWRQTLSG-----EVLGA 68
|
90 100 110
....*....|....*....|....*....|....*.
gi 1132400695 184 PLVINGKLITgVAGGefgvvGKIEAYDPKNGSLLWS 219
Cdd:pfam13360 69 PLVAGGRVFV-VAGD-----GSLIALDAADGRRLWS 98
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
94-226 |
1.61e-10 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 61.26 E-value: 1.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 94 DGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDDIRPccdvinrgvALYGDLVIFGTLDAKLVALNKDTGKVVWSKKVAD 173
Cdd:pfam13360 33 GGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAP---------LVAGGRVFVVAGDGSLIALDAADGRRLWSYQRSG 103
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 174 HKEGYSISAAPLVINGKLITGVAGgefgvvGKIEAYDPKNGSLLWSRPTVEGH 226
Cdd:pfam13360 104 EPLALRSSGSPAVVGDTVVAGFSS------GKLVALDPATGKVRWEAPLAAPR 150
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
470-538 |
1.24e-09 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 60.21 E-value: 1.24e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1132400695 470 GVLRAIDPKTGKEVWRHKNFAPLWGGVlTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPV 538
Cdd:COG1520 67 GRVAALDAATGKELWRVDLGEPLSGGV-GADGGLVVVGTEDGEVIALDADDGEELWRARLSSEVLAAPA 134
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
470-538 |
3.64e-09 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 57.41 E-value: 3.64e-09
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1132400695 470 GVLRAIDPKTGKEVWRHKNFAPLWGGVlTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPV 538
Cdd:pfam13360 3 GVVTALDAATGAELWRVDLETGLGGGV-AVDGGRLFVATGGGQLVALDAATGKLLWRQTLSGEVLGAPL 70
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
87-220 |
6.79e-08 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 54.65 E-value: 6.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 87 QAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccDVINRGVA--LYGDLVIFGTLD-AKLVALNKDTG 163
Cdd:cd10276 114 LSPPTYADGKIYVGTGDGRLYYCNAETGKVVWNRTSTAP-------ELSLRGGAapVGAYDVVFVGDGnGTVVALNTGTG 186
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1132400695 164 KVVWSKKVADHK-----EGYS-ISAAPLVINGKLITgVAGGefgvvGKIEAYDPKNGSLLWSR 220
Cdd:cd10276 187 VDIWEFSVSEPRgrtelPRMIdSSVTYVVVGGYLYS-TSYQ-----GYLVALDFESGQFLWSR 243
|
|
| PRK11138 |
PRK11138 |
outer membrane biogenesis protein BamB; Provisional |
470-538 |
1.28e-07 |
|
outer membrane biogenesis protein BamB; Provisional
Pssm-ID: 236857 [Multi-domain] Cd Length: 394 Bit Score: 54.17 E-value: 1.28e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 470 GVLRAIDPKTGKEVWR-----HKNF------APLWGGVLTTKGKlVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPV 538
Cdd:PRK11138 79 GLVKALDADTGKEIWSvdlseKDGWfsknksALLSGGVTVAGGK-VYIGSEKGQVYALNAEDGEVAWQTKVAGEALSRPV 157
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
467-559 |
4.36e-07 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 52.33 E-value: 4.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 467 DYIGVLRAIDPKTGKEVWRHK-NFAPLWGGVLTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTW----- 540
Cdd:cd10276 45 DANGQVSAFNATTGKIIWETSlSGKGFLGGTPAVGNGKIFVGTESGYLYALDAKDGSELWRTEVSDSQLLSPPTYadgki 124
|
90 100 110
....*....|....*....|....*....|....*...
gi 1132400695 541 ---EMDGEQY----------------VSVLSGWGGAVP 559
Cdd:cd10276 125 yvgTGDGRLYycnaetgkvvwnrtstAPELSLRGGAAP 162
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
86-219 |
8.15e-07 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 51.35 E-value: 8.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 86 QQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYD----------ARLPD-DIRPccdvinrgvALYGDLVIFGTLDAK 154
Cdd:COG1520 174 GTSSPVIVGGAVLVGFANGKLVALDLANGQPLWEQRvaqprgrtelERLVDvDGTP---------VVDGGVVYAVAYQGR 244
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1132400695 155 LVALNKDTGKVVWSKKVAdhkegysiSAAPLVINGKLItgvaggeFGV--VGKIEAYDPKNGSLLWS 219
Cdd:COG1520 245 LAALDLRSGRVLWSRDLS--------SYTGLAVDGNNL-------YVTddDGRVWALDRRNGAELWK 296
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
437-534 |
9.80e-07 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 50.09 E-value: 9.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 437 WGMDI---WNEGIAYKKGAAFLGAGFtikplnedyiGVLRAIDPKTGKEVWRHKNFAPLwGGVLTTKGKLVFTGTPEGFL 513
Cdd:pfam13360 17 WRVDLetgLGGGVAVDGGRLFVATGG----------GQLVALDAATGKLLWRQTLSGEV-LGAPLVAGGRVFVVAGDGSL 85
|
90 100
....*....|....*....|.
gi 1132400695 514 QAFNAKTGEKVWEFQTGSGVL 534
Cdd:pfam13360 86 IALDAADGRRLWSYQRSGEPL 106
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
504-537 |
3.31e-06 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 43.72 E-value: 3.31e-06
10 20 30
....*....|....*....|....*....|....
gi 1132400695 504 VFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSP 537
Cdd:pfam01011 3 VYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
470-526 |
1.35e-05 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 47.50 E-value: 1.35e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1132400695 470 GVLRAIDPKTGKEVWRHKNFAP---LWG-GVLTTKGKLVFTGTPEGFLQAFNAKTGEKVWE 526
Cdd:COG1520 147 GRVYALDAATGERLWSYQRPVPaltLRGtSSPVIVGGAVLVGFANGKLVALDLANGQPLWE 207
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
87-219 |
1.93e-05 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 46.94 E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 87 QAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPDDIRPCCDVI--NRGVALYGDLVIFGTLDAKLVALNKDTGK 164
Cdd:cd10276 159 GAAPVGAYDVVFVGDGNGTVVALNTGTGVDIWEFSVSEPRGRTELPRMIdsSVTYVVVGGYLYSTSYQGYLVALDFESGQ 238
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1132400695 165 VVWSKKvadHKEGYSIsaaPLVINGKLITGVAGGEFgvvgkiEAYDPKNGSLLWS 219
Cdd:cd10276 239 FLWSRK---ASGGTST---STDANGRVYVGDGEGSL------YCLDASTGDELWS 281
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
88-194 |
2.33e-05 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 46.85 E-value: 2.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 88 AQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARlpddirpccdvINRGVALYGDLVIFGTLDAKLVALNKDTGKVVW 167
Cdd:TIGR03300 235 GDPVVDGGQVYAVSYQGRVAALDLRSGRVLWKRDAS-----------SYQGPAVDDNRLYVTDADGVVVALDRRSGSELW 303
|
90 100
....*....|....*....|....*..
gi 1132400695 168 SKkvaDHKEGYSISaAPLVINGKLITG 194
Cdd:TIGR03300 304 KN---DELKYRQLT-APAVLGGYLVVG 326
|
|
| PRK11138 |
PRK11138 |
outer membrane biogenesis protein BamB; Provisional |
91-199 |
2.74e-05 |
|
outer membrane biogenesis protein BamB; Provisional
Pssm-ID: 236857 [Multi-domain] Cd Length: 394 Bit Score: 46.85 E-value: 2.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 91 MIKDGV-MYLTGSYSRVFAVDARTGKKLWQYDarlpddirpccDVINRGV---ALYGDLVIFGTLDAKLVALNKDTGKVV 166
Cdd:PRK11138 290 FAVDGGrIYLVDQNDRVYALDTRGGVELWSQS-----------DLLHRLLtapVLYNGYLVVGDSEGYLHWINREDGRFV 358
|
90 100 110
....*....|....*....|....*....|...
gi 1132400695 167 WSKKVadhkEGYSISAAPLVINGKLITGVAGGE 199
Cdd:PRK11138 359 AQQKV----DSSGFLSEPVVADDKLLIQARDGT 387
|
|
| PQQ_DH_like |
cd00216 |
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases ... |
470-591 |
1.87e-04 |
|
PQQ-dependent dehydrogenases and related proteins; This family is composed of dehydrogenases with pyrroloquinoline quinone (PQQ) as a cofactor, such as ethanol, methanol, and membrane-bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller, and the family also includes distantly related proteins which are not enzymatically active and do not bind PQQ.
Pssm-ID: 199833 [Multi-domain] Cd Length: 434 Bit Score: 44.13 E-value: 1.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 470 GVLRAIDPKTGKEVWRHK---------NFAPLWGGVLTTKGKLVFTGTPEGFLQAFNAKTGEKVWEFQTgSGVLGSpvtW 540
Cdd:cd00216 41 SRVFALDADDGKEIWSYDpalkdgwfeACCDLVNRGVAVWGGKVYIGVLDGRVYALNAETGKVAWKVKN-ADVLGG---Y 116
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1132400695 541 EMDGEQYVS---VLSGWGGAVPLWGGEVAKRikDFNQGGMLWTFklpkDLVAKH 591
Cdd:cd00216 117 TATSAPVVVdglVIIGSSGDEFGVRGYLTAY--DVATGEEKWRF----YLVMPD 164
|
|
| PRK11138 |
PRK11138 |
outer membrane biogenesis protein BamB; Provisional |
66-220 |
1.94e-04 |
|
outer membrane biogenesis protein BamB; Provisional
Pssm-ID: 236857 [Multi-domain] Cd Length: 394 Bit Score: 44.15 E-value: 1.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 66 NVKDLRPVWAFSFGGEkqrgQQAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccDVINRG----VAL 141
Cdd:PRK11138 136 NAEDGEVAWQTKVAGE----ALSRPVVSDGLVLVHTSNGMLQALNESDGAVKWTVNLDVP-------SLTLRGesapATA 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 142 YGDlVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYSIS------AAPLVINGKLITgvaggeFGVVGKIEAYDPKNGS 215
Cdd:PRK11138 205 FGG-AIVGGDNGRVSAVLMEQGQLIWQQRISQPTGATEIDrlvdvdTTPVVVGGVVYA------LAYNGNLVALDLRSGQ 277
|
....*
gi 1132400695 216 LLWSR 220
Cdd:PRK11138 278 IVWKR 282
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
470-539 |
2.35e-04 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 43.65 E-value: 2.35e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1132400695 470 GVLRAIDPKTGKEVWRhknfAPLWGGVLTT---KGKLVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVL-----GSPVT 539
Cdd:COG1520 107 GEVIALDADDGEELWR----ARLSSEVLAApavAGGRVVVRTGDGRVYALDAATGERLWSYQRPVPALtlrgtSSPVI 180
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
90-193 |
2.59e-04 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 43.77 E-value: 2.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 90 PMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDarlpddirpccDVINR---GVALYGDLVIFGTLDAKLVALNKDTGKVV 166
Cdd:TIGR03300 275 PAVDDNRLYVTDADGVVVALDRRSGSELWKND-----------ELKYRqltAPAVLGGYLVVGDFEGYLHWLDRDDGSFV 343
|
90 100
....*....|....*....|....*..
gi 1132400695 167 WSKKVadhkEGYSISAAPLVINGKLIT 193
Cdd:TIGR03300 344 ARLKT----DGSGIASPPVVVGDGLLV 366
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
87-168 |
2.71e-04 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 42.78 E-value: 2.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 87 QAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLPddirpccdvinRGVALYGDLVIFGTLDAKLVALNKDTGKVV 166
Cdd:pfam13360 162 TGTPVVAGGRVFASAYQGRLVAFDAATGRRLWTREISGP-----------NGPILDGDLLYVVSDDGELYALDRATGAVV 230
|
..
gi 1132400695 167 WS 168
Cdd:pfam13360 231 WK 232
|
|
| PQQ |
COG1520 |
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell ... |
71-192 |
3.22e-04 |
|
Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441129 [Multi-domain] Cd Length: 370 Bit Score: 43.26 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 71 RPVWAFSFGGekqrgqqAQPM-IKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLpddirpccdviNRGV---ALYGDLV 146
Cdd:COG1520 254 RVLWSRDLSS-------YTGLaVDGNNLYVTDDDGRVWALDRRNGAELWKQDALL-----------YRGLtapVVLGDYV 315
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1132400695 147 IFGTLDAKLVALNKDTGKVVWSKKVAdhkeGYSISAAPLVINGKLI 192
Cdd:COG1520 316 VVGDFEGYLHWLSRDDGSLVARLRVD----GSGIRAAPVVVGDTLY 357
|
|
| Luminal_IRE1_like |
cd09213 |
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The ... |
94-221 |
1.09e-03 |
|
The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; The Luminal domain is a dimerization domain present in Inositol-requiring protein 1 (IRE1), eukaryotic translation Initiation Factor 2-Alpha Kinase 3 (EIF2AK3), and similar proteins. IRE1 and EIF2AK3 are serine/threonine protein kinases (STKs) and are type I transmembrane proteins that are localized in the endoplasmic reticulum (ER). They are kinase receptors that are activated through the release of BiP, a chaperone bound to their luminal domains under unstressed conditions. This results in dimerization through their luminal domains, allowing trans-autophosphorylation of their kinase domains and activation. They play roles in the signaling of the unfolded protein response (UPR), which is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), contains an endoribonuclease domain in its cytoplasmic side and acts as an ER stress sensor. It is the oldest and most conserved component of the UPR in eukaryotes. Its activation results in the cleavage of its mRNA substrate, HAC1 in yeast and Xbp1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. EIF2AK3, also called PKR-like Endoplasmic Reticulum Kinase (PERK), phosphorylates the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. It functions as the central regulator of translational control during the UPR pathway. In addition to the eIF-2 alpha subunit, EIF2AK3 also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR.
Pssm-ID: 188873 [Multi-domain] Cd Length: 312 Bit Score: 41.32 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 94 DGVMYLTGSYSRVFAVDARTGK--------KLWQYDARLPDDIRPCCDVINrgvALYGDLVIFGTLDAKLVALNKDTGKV 165
Cdd:cd09213 93 DDVVVVGSKRTSVFALDAKTGKiiktyradGLPSTGGSDSDGNSTPGPDEL---QEEEELLYIGRTDYVLQAIDPRSGKE 169
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1132400695 166 VWSKKVADHKEGYSISAAPLV--INGKLITGVAGGEFGVVGKIEAYDPKNGSLLWSRP 221
Cdd:cd09213 170 LWNVTYGEYEALTLDADELGTssSSSPLSASFRISENEPVPAVYLLGLQGGKSLWEHL 227
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
144-179 |
1.35e-03 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 36.40 E-value: 1.35e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1132400695 144 DLVIFGTLDAKLVALNKDTGKVVWSKKVADHKEGYS 179
Cdd:pfam01011 1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
|
|
| BamB_YfgL |
cd10276 |
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is ... |
348-580 |
1.53e-03 |
|
Beta-barrel assembly machinery (Bam) complex component B and related proteins; BamB (YflG) is a non-essential component of the beta-barrel assembly machinery (Bam), a multi-subunit complex that inserts proteins with beta-barrel topology into the outer membrane. BamB has been found to interact with BamA, which in turn binds and stabilizes pre-folded beta-barrel proteins; it has been suggested that BamB participates in the stabilization.
Pssm-ID: 199834 [Multi-domain] Cd Length: 358 Bit Score: 41.16 E-value: 1.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 348 ADRNGFFYVLDRTNGKFIrgfpfvdkitWATGLDKEGRPIyneasrpgapGTEAKGSSVfvapAFLGAKNWMPMAYNKDT 427
Cdd:cd10276 44 ADANGQVSAFNATTGKII----------WETSLSGKGFLG----------GTPAVGNGK----IFVGTESGYLYALDAKD 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 428 G--LF--YVPSNEWgmdiwNEGIAYKKGAAFLGAGFtikplnedyiGVLRAIDPKTGKEVWRHKNFAP---LWGG--VLT 498
Cdd:cd10276 100 GseLWrtEVSDSQL-----LSPPTYADGKIYVGTGD----------GRLYYCNAETGKVVWNRTSTAPelsLRGGaaPVG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 499 TKGKlVFTGTPEGFLQAFNAKTGEKVWEFQTGSGVLGSPVTWE-------MDGEQYVSVLSGWGGAVPLwggevakrikD 571
Cdd:cd10276 165 AYDV-VFVGDGNGTVVALNTGTGVDIWEFSVSEPRGRTELPRMidssvtyVVVGGYLYSTSYQGYLVAL----------D 233
|
....*....
gi 1132400695 572 FNQGGMLWT 580
Cdd:cd10276 234 FESGQFLWS 242
|
|
| PRK11138 |
PRK11138 |
outer membrane biogenesis protein BamB; Provisional |
422-579 |
1.67e-03 |
|
outer membrane biogenesis protein BamB; Provisional
Pssm-ID: 236857 [Multi-domain] Cd Length: 394 Bit Score: 41.07 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 422 AYNKDTGlfyvpsnewgMDIWNEGIAYKKGA------AFLGAGFTIKpLNEDYIG----VLRAIDPKTGKEVWRHKnfap 491
Cdd:PRK11138 83 ALDADTG----------KEIWSVDLSEKDGWfsknksALLSGGVTVA-GGKVYIGsekgQVYALNAEDGEVAWQTK---- 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 492 LWGGVL---TTKGKLVFTGTPEGFLQAFNAKTGEKVWefqtgsgvlgspvTWEMD-------GEQYVSVLSG---WGGAv 558
Cdd:PRK11138 148 VAGEALsrpVVSDGLVLVHTSNGMLQALNESDGAVKW-------------TVNLDvpsltlrGESAPATAFGgaiVGGD- 213
|
170 180
....*....|....*....|.
gi 1132400695 559 plwGGEVAKRIKdfNQGGMLW 579
Cdd:PRK11138 214 ---NGRVSAVLM--EQGQLIW 229
|
|
| PQQ |
pfam01011 |
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller ... |
95-130 |
2.04e-03 |
|
PQQ enzyme repeat; The family represent a single repeat of a beta propeller. This propeller has been found in several enzymes which utilize pyrrolo-quinoline quinone as a prosthetic group.
Pssm-ID: 395799 [Multi-domain] Cd Length: 36 Bit Score: 36.02 E-value: 2.04e-03
10 20 30
....*....|....*....|....*....|....*.
gi 1132400695 95 GVMYLTGSYSRVFAVDARTGKKLWQYDARLPDDIRP 130
Cdd:pfam01011 1 GTVYLGSDDGYLYALDAETGKVLWSFKTGGAVLSSP 36
|
|
| assembly_YfgL |
TIGR03300 |
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a ... |
84-226 |
2.36e-03 |
|
outer membrane assembly lipoprotein YfgL; Members of this protein family are YfgL, a lipoprotein component of a complex that acts protein insertion into the bacterial outer membrane. Other members of this complex are NlpB, YfiO, and YaeT. This protein contains multiple copies of a repeat that, in other contexts, are associated with binding of the coenzyme PQQ. [Protein fate, Protein and peptide secretion and trafficking]
Pssm-ID: 274511 [Multi-domain] Cd Length: 377 Bit Score: 40.69 E-value: 2.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 84 RGQqAQPMIKDGVMYLTGSYSRVFAVDARTGKKLWQYDARLP---DDIRPCCDVINRGVALyGDLVIFGTLDAKLVALNK 160
Cdd:TIGR03300 181 RGS-ASPVIADGGVLVGFAGGKLVALDLQTGQPLWEQRVALPkgrTELERLVDVDGDPVVD-GGQVYAVSYQGRVAALDL 258
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1132400695 161 DTGKVVWSKKVAdhkegysiSAAPLVINGKLITGVAGGefgvvGKIEAYDPKNGSLLWSRPTVEGH 226
Cdd:TIGR03300 259 RSGRVLWKRDAS--------SYQGPAVDDNRLYVTDAD-----GVVVALDRRSGSELWKNDELKYR 311
|
|
| PQQ_2 |
pfam13360 |
PQQ-like domain; This domain contains several repeats of the PQQ repeat. |
152-332 |
4.03e-03 |
|
PQQ-like domain; This domain contains several repeats of the PQQ repeat.
Pssm-ID: 433144 [Multi-domain] Cd Length: 233 Bit Score: 39.31 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 152 DAKLVALNKDTGKVVWSkkvADHKEGysISAAPLVINGKLITGvaggefGVVGKIEAYDPKNGSLLWSR---------PT 222
Cdd:pfam13360 2 DGVVTALDAATGAELWR---VDLETG--LGGGVAVDGGRLFVA------TGGGQLVALDAATGKLLWRQtlsgevlgaPL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1132400695 223 VEGHMGYTYkdgkAVENGISGGEAgktwpgdlwKTGGAApWlgGYYDPETNLLLFGTGNPAPwnshlrPGDNLY---SSS 299
Cdd:pfam13360 71 VAGGRVFVV----AGDGSLIALDA---------ADGRRL-W--SYQRSGEPLALRSSGSPAV------VGDTVVagfSSG 128
|
170 180 190
....*....|....*....|....*....|....*
gi 1132400695 300 RL-ALNPDDGTIKW-HFQSTPHDGWDYDGVNELVS 332
Cdd:pfam13360 129 KLvALDPATGKVRWeAPLAAPRGTNELERLVDITG 163
|
|
| PA2928_fam |
NF041516 |
PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa ... |
102-170 |
8.59e-03 |
|
PA2928 family protein; This family is named for the locus PA2928 of Pseudomonas aeroginosa PAO1, as the family member most frequently cited in the literature, although PA2928 itself is significantly shorter at the N-terminus than most other members of this family, and is probably non-functional. WP_017001489.1 represents an intact equivalent to the PA2928 pseudogene.
Pssm-ID: 469402 [Multi-domain] Cd Length: 345 Bit Score: 38.50 E-value: 8.59e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1132400695 102 SYSRVFAVDARTGKKLWqyDARLPDDirpccdvINRGVALYG---DLVIFGTlDAKLVALNKDTGKVVWSKK 170
Cdd:NF041516 67 SQFRLAAVDLATGEKLW--DKKLSDE-------LSWEAYLLGatdRYLYVAT-DKGLYVLDLATGKVVADEK 128
|
|
| |
