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Conserved domains on  [gi|1130874348|ref|WP_075647001|]
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sugar porter family MFS transporter [Oenococcus oeni]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
28-443 9.51e-102

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17359:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 383  Bit Score: 309.11  E-value: 9.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSKPdqLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCA 107
Cdd:cd17359     7 ALGGLLFGYDTGVINGALPFLQTD--FNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 108 LSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNW---NPIWRI 184
Cdd:cd17359    85 FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADwlgAEGWRW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 185 MIVSASIPAIILWINSFHIVGSPHWLLLKKRfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpslvYL 264
Cdd:cd17359   165 MLGLEAIPAILFLLGMLFIPESPRWLVSKGK-----------------------------------------------PI 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 265 LISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLA 344
Cdd:cd17359   198 LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 345 LLGLVLRLSLFTQtITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISA 424
Cdd:cd17359   278 LIGTAFYFAPGSQ-ASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAA 356
                         410
                  ....*....|....*....
gi 1130874348 425 VGTAVVFFIFAASNGVSAL 443
Cdd:cd17359   357 FGLAFTFLIFAVICVLAFL 375
 
Name Accession Description Interval E-value
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
28-443 9.51e-102

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 309.11  E-value: 9.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSKPdqLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCA 107
Cdd:cd17359     7 ALGGLLFGYDTGVINGALPFLQTD--FNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 108 LSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNW---NPIWRI 184
Cdd:cd17359    85 FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADwlgAEGWRW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 185 MIVSASIPAIILWINSFHIVGSPHWLLLKKRfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpslvYL 264
Cdd:cd17359   165 MLGLEAIPAILFLLGMLFIPESPRWLVSKGK-----------------------------------------------PI 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 265 LISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLA 344
Cdd:cd17359   198 LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 345 LLGLVLRLSLFTQtITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISA 424
Cdd:cd17359   278 LIGTAFYFAPGSQ-ASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAA 356
                         410
                  ....*....|....*....
gi 1130874348 425 VGTAVVFFIFAASNGVSAL 443
Cdd:cd17359   357 FGLAFTFLIFAVICVLAFL 375
Sugar_tr pfam00083
Sugar (and other) transporter;
24-449 2.12e-73

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 238.33  E-value: 2.12e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  24 TYIISIGGFLFGYDTGVINGALAFMSKP---------DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRW 94
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFknfglsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  95 IAALFTSSTILCALS---MNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFL 171
Cdd:pfam00083  82 ANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 172 GNIWGNWNpiWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFE---KSTFDGIeQESKTKSKKDD 248
Cdd:pfam00083 162 NKTSNSDG--WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVpdvDRELDEI-KDSLEAGQEAE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 249 DISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMgqSGSLYANILIGLVSFVASIFGTRLIARFDH 328
Cdd:pfam00083 239 KASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIFLVDRFGR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 329 HRMLLIGLFGNILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTW 408
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANW 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1130874348 409 ITNFIISLIYPLLISAVGTAVVFFIFAasnGVSALLSIFVL 449
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFA---GLLVLFIIFVF 434
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
3-449 1.86e-68

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 226.07  E-value: 1.86e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348   3 ERIKLLEPKKSKFNNSFLKYSTYIISIGGFLFGYDTGVINGALAFMS--KPDQLNLTPG----LQGVVSSSLVLGAFFGA 76
Cdd:TIGR00879   9 ASELLVTPAGLGSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAfeFKFTSANSDSysssLWGLVVSIFLVGGFIGA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  77 LGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMS---FFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKN 153
Cdd:TIGR00879  89 LFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEmliVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 154 AIFIVLGQLSAFCMNAflGNIWGNWNPIWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFEKSTF 233
Cdd:TIGR00879 169 QLAITFGILVAYGFGS--GKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGED 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 234 DGIEQE------SKTKSKKDDDISWKSILK-KPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANI 306
Cdd:TIGR00879 247 KELLDElelidiKRSIEKRSVQPSWGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSI 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 307 LIGLVSFVASIFGTRLIARFDHHRMLLIGLFGN-ILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWL 385
Cdd:TIGR00879 327 IVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMaICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWV 406
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 386 IMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSIFVL 449
Cdd:TIGR00879 407 IVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFL 470
xylE PRK10077
D-xylose transporter XylE; Provisional
12-421 1.99e-52

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 183.74  E-value: 1.99e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  12 KSKFNNSFLKYSTYIISIGGFLFGYDTGVINGAL----AFMSKPDQLN--LTPGLQGVVSSSLVLGAFFGALGCGRIADK 85
Cdd:PRK10077    2 NTQYNSSYIFSITLVATLGGLLFGYDTAVISGTVeslnTVFVAPQNLSesAANSLLGFCVASALIGCIIGGALGGYCSNR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  86 FGRKQTLRWIAALFTSSTILCAL-----------SMNFLFM-SFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKN 153
Cdd:PRK10077   82 FGRRDSLKIAAVLFFISALGSAWpefgftsigpdNTGYVPEfVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 154 AIFIVLGQLSAFCMNAFL----GNIWGNWNPiWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFE 229
Cdd:PRK10077  162 QFAIIFGQLVVYFVNYFIarsgDASWLNTDG-WRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 230 ---KSTFDGIEQESKTKSKKdddiswksilKKPSLVY---LLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLY 303
Cdd:PRK10077  241 tlaTQALQEIKHSLDHGRKT----------GGKLLMFgvgVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALL 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 304 ANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGnILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHqgivSPVT 383
Cdd:PRK10077  311 QTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALG-MAIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAMSW----GPVC 385
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1130874348 384 WLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLL 421
Cdd:PRK10077  386 WVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMM 423
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
26-409 1.88e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 118.15  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAA--DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIM 185
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-----WRWV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 186 IVSASIPAIILWINSfhivgsphWLLLKkrfkkarklfsklgfekstfdgieqESKTKSKKDDDISWKSILKKPSLVYLl 265
Cdd:COG2814   167 FLVNAVLALLALLLL--------LRLLP-------------------------ESRPAARARLRGSLRELLRRPRLLLL- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 266 isgILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLAL 345
Cdd:COG2814   213 ---LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 346 LGlvlrlslftqTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWI 409
Cdd:COG2814   290 LA----------LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
 
Name Accession Description Interval E-value
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
28-443 9.51e-102

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 309.11  E-value: 9.51e-102
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSKPdqLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCA 107
Cdd:cd17359     7 ALGGLLFGYDTGVINGALPFLQTD--FNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 108 LSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNW---NPIWRI 184
Cdd:cd17359    85 FSPNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGADwlgAEGWRW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 185 MIVSASIPAIILWINSFHIVGSPHWLLLKKRfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpslvYL 264
Cdd:cd17359   165 MLGLEAIPAILFLLGMLFIPESPRWLVSKGK-----------------------------------------------PI 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 265 LISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLA 344
Cdd:cd17359   198 LIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILLVDKVGRKPLLLIGSIGMAISLL 277
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 345 LLGLVLRLSLFTQtITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISA 424
Cdd:cd17359   278 LIGTAFYFAPGSQ-ASGIVALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAMGIAVFFLWIANFLVSLTFPILLAA 356
                         410
                  ....*....|....*....
gi 1130874348 425 VGTAVVFFIFAASNGVSAL 443
Cdd:cd17359   357 FGLAFTFLIFAVICVLAFL 375
Sugar_tr pfam00083
Sugar (and other) transporter;
24-449 2.12e-73

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 238.33  E-value: 2.12e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  24 TYIISIGGFLFGYDTGVINGALAFMSKP---------DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRW 94
Cdd:pfam00083   2 ALVAALGGFLFGYDTGVIGAFLTLIDFFknfglsksvSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  95 IAALFTSSTILCALS---MNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFL 171
Cdd:pfam00083  82 ANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 172 GNIWGNWNpiWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFE---KSTFDGIeQESKTKSKKDD 248
Cdd:pfam00083 162 NKTSNSDG--WRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAREVLAKLRGVpdvDRELDEI-KDSLEAGQEAE 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 249 DISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMgqSGSLYANILIGLVSFVASIFGTRLIARFDH 328
Cdd:pfam00083 239 KASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGL--SDSFLVTIIVGVVNFVFTFIAIFLVDRFGR 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 329 HRMLLIGLFGNILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTW 408
Cdd:pfam00083 317 RPLLLLGAAGMAICFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANW 396
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1130874348 409 ITNFIISLIYPLLISAVGTAVVFFIFAasnGVSALLSIFVL 449
Cdd:pfam00083 397 LANFLIGFLFPIITDAIGLGYTFFIFA---GLLVLFIIFVF 434
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
26-449 1.26e-68

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 223.22  E-value: 1.26e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKPDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:cd17315     1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNWnpiWRIM 185
Cdd:cd17315    81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLSPPGW---WRLM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 186 IVSASIPAIILWINSFHIVGSPhwlllkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpslvyLL 265
Cdd:cd17315   158 FALAAVPALLQLLLMFFLPESR--------------------------------------------------------AL 181
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 266 ISGILIALIQQISGVNTVMYYGTILMEKVGmGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNIlFLAL 345
Cdd:cd17315   182 LVGVGLQLLQQLTGINAVMYYAPTIFKSAG-GGTASILASIIVGVVNLLATLVAIRLVDKVGRRPLLLIGFAGMA-ASLL 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 346 LGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAV 425
Cdd:cd17315   260 LLAIAFLLPALAKAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWIFNFIVGLTFLIMVSTI 339
                         410       420
                  ....*....|....*....|....
gi 1130874348 426 GTAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17315   340 GLAGVFIFFAAVCLLALVFVFFFV 363
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
3-449 1.86e-68

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 226.07  E-value: 1.86e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348   3 ERIKLLEPKKSKFNNSFLKYSTYIISIGGFLFGYDTGVINGALAFMS--KPDQLNLTPG----LQGVVSSSLVLGAFFGA 76
Cdd:TIGR00879   9 ASELLVTPAGLGSTYWKVALLSLIAAIGGLMFGYDTGVIGGALALPAfeFKFTSANSDSysssLWGLVVSIFLVGGFIGA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  77 LGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMS---FFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKN 153
Cdd:TIGR00879  89 LFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEmliVGRVLLGIGVGIASALVPMYLSEIAPKALRGALTSLY 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 154 AIFIVLGQLSAFCMNAflGNIWGNWNPIWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFEKSTF 233
Cdd:TIGR00879 169 QLAITFGILVAYGFGS--GKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARLRGTSGED 246
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 234 DGIEQE------SKTKSKKDDDISWKSILK-KPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANI 306
Cdd:TIGR00879 247 KELLDElelidiKRSIEKRSVQPSWGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVSTDHAFLVSI 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 307 LIGLVSFVASIFGTRLIARFDHHRMLLIGLFGN-ILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWL 385
Cdd:TIGR00879 327 IVGAVNFAFTFVAIFLVDRFGRRPLLLIGAAGMaICLFVLGILGASFVTGSSKSSGNVAIVFILLFIAFFAMGWGPVPWV 406
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 386 IMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSIFVL 449
Cdd:TIGR00879 407 IVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTMLESIGVGGVFIFFGGLNVLGLIFVYFFL 470
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
28-449 1.33e-61

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 204.81  E-value: 1.33e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSK-PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd17360     3 GIGGFLFGYDTGVISGALLYIKDdLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNwnpiWRIMI 186
Cdd:cd17360    83 AAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGG----WRWML 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 187 VSASIPAIILWINSFHIVGSPHWlllkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkPSLVYLLI 266
Cdd:cd17360   159 GLAAVPAVLQFIGLLFLPESPRW-------------------------------------------------PSTRRALI 189
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 267 SGILIALIQQISGVNTVMYYGTILMEKVGMGQSG-SLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLAL 345
Cdd:cd17360   190 VGCGLQAFQQFSGINTVMYYSATILQMAGFKDNQnAIWLSLIVAGTNFIFTIVGMYLIDKFGRRKLLLISLFGVIVALVV 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 346 lglvlrlslftqtITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAV 425
Cdd:cd17360   270 -------------LAVWLALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAI 336
                         410       420
                  ....*....|....*....|....
gi 1130874348 426 GTAVVFFIFAasnGVSALLSIFVL 449
Cdd:cd17360   337 GPYGTFLLFA---GLAVLGLIFIY 357
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
23-449 6.34e-54

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 186.63  E-value: 6.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  23 STYIISIGGFLFGYDTGVINGALAFMSK--PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFT 100
Cdd:cd17358     3 ATFVANLGSFSFGIAVGWSSPALPSLMSdnSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIGRKRTLLISAIPCI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 101 SSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGniwgnwnp 180
Cdd:cd17358    83 LGWLLIAFAKDVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLGYVLGSFLP-------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 181 iWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKL-GFEKSTFDGIE--QESKTKSKKDDDISWKSILK 257
Cdd:cd17358   155 -WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQFLrGKDADISKEAAeiQEELAELEKEAKESSFSDLF 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 258 KPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLyANILIGLVSFVASIFGTRLIARFDHHRMLLIGLF 337
Cdd:cd17358   234 QRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGLDPNT-ATIIIGVVQVVGTLVATLLVDRLGRRPLLLVSAI 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 338 GNILFLALLGLVLRLSLFTQTITNA--LVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIIS 415
Cdd:cd17358   313 GMGIGLLALGLYFYLQEHGALLSSVswLPLVGLVIYIISFSIGLGPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVT 392
                         410       420       430
                  ....*....|....*....|....*....|....
gi 1130874348 416 LIYPLLISAVGTAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17358   393 KTFPFLTLAWGASGTFWIFAGICGLALVFVLLFV 426
xylE PRK10077
D-xylose transporter XylE; Provisional
12-421 1.99e-52

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 183.74  E-value: 1.99e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  12 KSKFNNSFLKYSTYIISIGGFLFGYDTGVINGAL----AFMSKPDQLN--LTPGLQGVVSSSLVLGAFFGALGCGRIADK 85
Cdd:PRK10077    2 NTQYNSSYIFSITLVATLGGLLFGYDTAVISGTVeslnTVFVAPQNLSesAANSLLGFCVASALIGCIIGGALGGYCSNR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  86 FGRKQTLRWIAALFTSSTILCAL-----------SMNFLFM-SFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKN 153
Cdd:PRK10077   82 FGRRDSLKIAAVLFFISALGSAWpefgftsigpdNTGYVPEfVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVSFN 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 154 AIFIVLGQLSAFCMNAFL----GNIWGNWNPiWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFE 229
Cdd:PRK10077  162 QFAIIFGQLVVYFVNYFIarsgDASWLNTDG-WRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRKIMGN 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 230 ---KSTFDGIEQESKTKSKKdddiswksilKKPSLVY---LLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLY 303
Cdd:PRK10077  241 tlaTQALQEIKHSLDHGRKT----------GGKLLMFgvgVIVIGVMLSVFQQFVGINVVLYYAPEIFKTLGASTDIALL 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 304 ANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGnILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHqgivSPVT 383
Cdd:PRK10077  311 QTIIVGVINLTFTVLAIMTVDKFGRKPLQIIGALG-MAIGMFSLGTAFYTQAPGIVALLSMLFYVAAFAMSW----GPVC 385
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1130874348 384 WLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLL 421
Cdd:PRK10077  386 WVLLSEIFPNAIRGKALAIAVAAQWIANYFVSWTFPMM 423
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
28-447 4.52e-49

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 172.54  E-value: 4.52e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSKP-----DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSS 102
Cdd:cd17362     3 ALGGLLFGYDIGATSGALLSITSPalsgtDWYNLSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLYLVG 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 103 TILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMN-AFLGNIWGnwnpi 181
Cdd:cd17362    83 SLVTGLAPSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSGyAFADVVGG----- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 182 WRIMIVSASIPAIILWINSFHIVGSPHWlllKKRFKKArklfsklgfekstfdgieqesktkskkdddiswksilkkpsl 261
Cdd:cd17362   158 WRYMYGLAAPPALLLGIGMWFLPPSPRW---QGNYRKP------------------------------------------ 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 262 vylLISGILIALIQQISGVNTVMYYGTILMEKVGM-GQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNI 340
Cdd:cd17362   193 ---LIIGLGLVLFQQITGQPSVLYYAATIFKSAGFsAASDATLVSVGLGVFKLLMTIVAVLLVDKLGRRPLLLGGVSGMV 269
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 341 LFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPL 420
Cdd:cd17362   270 VSLFLLAAYNLFVQMGPAGLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGSNALVSLAFLP 349
                         410       420
                  ....*....|....*....|....*..
gi 1130874348 421 LISAVGTAVVFFIFaASNGVSALLSIF 447
Cdd:cd17362   350 LQELIGLPGTFLGF-GVIGVLALLFIY 375
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
24-447 8.48e-49

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 172.05  E-value: 8.48e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  24 TYIISIGGFLFGYDTGVINGAL-------AFMSKPDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIA 96
Cdd:cd17356     3 CAFVSLGGFLFGYDTGSISGILnmksfqkYFADNTGTYYPSSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGC 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  97 ALFTSSTILCALSMNFLFMSFF-RFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIW 175
Cdd:cd17356    83 VIYIIGAIIQVAAIGKWYQLIVgRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHKLD 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 176 GNWNpiWRIMIVSASIPAIILWINSFHIVGSPHWLllkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksi 255
Cdd:cd17356   163 GSAQ--WRIPLGLQIVWGLLLLIGMFFLPESPRWL--------------------------------------------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 256 lkkpslvYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIG 335
Cdd:cd17356   196 -------YRTILGIMLQLFQQLTGINYFFYYGTTIFQSTGLTGSSPLLTSIILYIVNFVSTIPGLFFVDKFGRRTCLLIG 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 336 -------LFGNILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTW 408
Cdd:cd17356   269 aagmsicLFIYAAVGVRYLIPNPQSGTSNKSAGNGMIVFICLFIFSFATTWGPIAWVYVAEVFPLRVRSKGMALATAFNW 348
                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1130874348 409 ITNFIISLIYPLLISAVGtAVVFFIFAASNGVSALLSIF 447
Cdd:cd17356   349 LWNFLISFFTPFIIGSIG-FKYYYIFAGCNLLAFIVVFF 386
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
26-449 4.17e-45

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 163.20  E-value: 4.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFM--------SKPDQLNLTPG----LQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLR 93
Cdd:cd17357     4 VAFGGSFQFGYNIGVVNAPQEVFkefindtlVDRYGLNLSDSeldlLWSLIVSIFFIGGAIGSFISAFLANRFGRKNGLL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  94 WIAALFTSSTILCALS---MNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVR-TINVNkNAIFIVLGQLSA--FCM 167
Cdd:cd17357    84 ISNALLVVSSLLMFLSksaKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRgALGSL-TQIGVTLGILLGqvFGL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 168 NAFLGNIWGnwnpiWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKA-----RKLFSKLGFEKSTFDGIEQESKT 242
Cdd:cd17357   163 PSVLGTETL-----WPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEaekslKFLRGIEDDVDQELEEIKKESEQ 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 243 KSKkDDDISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRL 322
Cdd:cd17357   238 MGD-QKQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 323 IARFDHHRMLLIGLFGNILFLALLGLVLRLSLFTQTITNALvLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSI 402
Cdd:cd17357   317 IEKVGRRPLLLISLSVCAVALLLMSVFLFLSEQNSWMSYGC-IVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSAAQSL 395
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*..
gi 1130874348 403 ATATTWITNFIISLIYPLLISAVGTAvVFFIFAASNGVSALLSIFVL 449
Cdd:cd17357   396 GSSVNWTSNFIVGMAFPPLQSIGGGF-VFIIFAIPCALFLLYLYRYL 441
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
28-448 3.64e-39

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 145.62  E-value: 3.64e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMSkpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCA 107
Cdd:cd17437     3 SLNSILLGYDIGVMSGAVIFIK--EDLKISDVQEEVLIGSLNIISLVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 108 LSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNWNpiWRIMIV 187
Cdd:cd17437    81 VAPNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFLTSFPEIFINIGILLGYVSNYAFSGLPLHVG--WRLMLG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 188 SASIPAIILWINSFHIVGSPHWlllkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksilkKPSLVYLLIS 267
Cdd:cd17437   159 VGAVPSLFLAIGVLAMPESPRW------------------------------------------------TPAVRRMLIA 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 268 GILIALIQQISGVNTVMYYGTILMEKVGM-GQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFG-NILFLAL 345
Cdd:cd17437   191 ALGIHFFQQASGIDAVVLYSPRIFKKAGIkSKDKLLLATVAVGVTKTLFILVATFLLDKVGRRPLLLTSTGGmTLSLTAL 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 346 LGLVLRLSLFTQTITNALVLIFLAL--FLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLIS 423
Cdd:cd17437   271 ATSLTFIDRNGGGLTWALVLAITAVcsFVAFFSIGAGPITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTFLSMSK 350
                         410       420
                  ....*....|....*....|....*
gi 1130874348 424 AVGTAVVFFIFAasnGVSALLSIFV 448
Cdd:cd17437   351 AITTGGTFFLFA---GVAAAAWVFF 372
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
22-435 8.47e-32

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 126.30  E-value: 8.47e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  22 YSTYIISIGGFLFGYDTGVING-------------ALAFMSKPDQLNLTPgLQGVVSSSLVLGAFFGALGCGRIADKFGR 88
Cdd:cd17431     1 FAVFVAVLGSLQFGYNTGVINApqkvieefynktlGDRYGEPISPETLTT-LWSLSVAIFSVGGMIGSFSVGLFVNRFGR 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  89 KQT------LRWIAALFTSstiLCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQL 162
Cdd:cd17431    80 RNSmlynnlLAFAGAALMG---LSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGIL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 163 SA--FCMNAFLGNiwgnwNPIWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFK-KARKLFSKL-GFEKSTFDGIE- 237
Cdd:cd17431   157 ISqiFGLEFILGT-----EELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEeEAKSVLKKLrGTTDVSEDIQEm 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 238 QESKTKSKKDDDISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQsgSLYANILIGLVSFVASI 317
Cdd:cd17431   232 KEESRQMMREKKVTILELFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQ--PVYATIGAGVVNTIFTV 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 318 FGTRLIARFDHHRMLLIGLFGnilflallglvlrLSLFTQTITNALVL------------IFLALFLASHQGIVSPVTWL 385
Cdd:cd17431   310 VSLFLVERAGRRTLHLIGLGG-------------MAICAILMTIALLLlegypwmsyvsiVAIFGFVAFFEIGPGPIPWF 376
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1130874348 386 IMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGtAVVFFIFA 435
Cdd:cd17431   377 IVAELFSQGPRPAAMAVAGFSNWTSNFIVGMCFQYIANLCG-PYVFIIFT 425
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
23-452 1.34e-31

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 124.52  E-value: 1.34e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  23 STYIISIGGFLFGYDTGVINGALAFMSkpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSS 102
Cdd:cd17435     2 SSVTAAVSGLLVGYELGIISGALLQLR--TLLALSCHEQEMVVSSLLIGALLASLTGGVLIDRYGRRTAIILTSCLLVLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 103 TILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIwgnwNPIW 182
Cdd:cd17435    80 SLLLVCSVSYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAYISNYAFANV----SNGW 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 183 RIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFkKARklfsklgfekstfdgieqesktkskkdddiswksilkkpslv 262
Cdd:cd17435   156 KYMFGLVIPLAALQAIAMYFLPPSPRFLVMKDNM-RAR------------------------------------------ 192
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 263 ylLISGILIALIQQISGVNTVMYYGTILMEKVGM-GQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGlfgnil 341
Cdd:cd17435   193 --LLIGLTLVFFVQITGQPNILFYASTVLKSVGFqSNEAASLASTGVGVVKVVSTIPAIFLVDKVGSKTFLCIG------ 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 342 flallglVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLL 421
Cdd:cd17435   265 -------SSVMAVSLVTMGLWLSLASLLVYVAAFSIGLGPMPWLVLSEIFPGGIRGRAMALTSSMNWGINLLISLTFLTV 337
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1130874348 422 ISAVGTAVVFFIFAASNGVSALLSI-FVLNAK 452
Cdd:cd17435   338 TELIGLPWVCFIYTAMSLASLVFVImFVPETK 369
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
26-449 2.10e-31

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 124.28  E-value: 2.10e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALA---FMSK--PDQLNLT-------------PGLQgVVSSSLVLGAFFGALGCGRIADKFG 87
Cdd:cd17361     1 VAALGGLIFGYDIGISGGVTSmdpFLEKffPSVYEKKkgasennyckyddQLLQ-LFTSSLYLAGLVASLLASYVTRKWG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  88 RKQTLRWIAALFTSSTILCALSMNfLFMSFF-RFALGLSVGAASSLSPMYLAEISPEPVR-TINVNKNaIFIVLGQLSAF 165
Cdd:cd17361    80 RKPSMLIGGVLFLVGAALNAAAQN-IAMLIVgRILLGFGVGFGNQAVPLYLSEMAPAKLRgALNIGFQ-LAITIGILIAN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 166 CMNAFLGNI--WGnwnpiWRIMIVSASIPAIILWINSFHIVGSPHwlllkkrfkkarklfsklgfekstfdgieqesktk 243
Cdd:cd17361   158 LINYGTSKIkpNG-----WRLSLGLAAVPALILLLGSLFLPETPN----------------------------------- 197
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 244 skkdddiswksilkKPSLVYllisGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLI 323
Cdd:cd17361   198 --------------SPQLVI----AILIPFFQQLTGINVIMFYAPVLFQTLGFGSDASLISAVITGAVNVVSTLVSIYLV 259
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 324 ARFDHHRMLLIG----LFGNILFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARF 399
Cdd:cd17361   260 DRFGRRFLLLEGgvqmLASQVAIGILLAVKFGDGGELPKAYAIAVVVLICLYVAAFAWSWGPLGWLVPSEIFPLETRSAG 339
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|
gi 1130874348 400 MSIATATTWITNFIISLIYPLLISAVGTAVvfFIFAAsnGVSALLSIFVL 449
Cdd:cd17361   340 QSLTVAVNFLFTFVIAQAFLSMLCAMKFGI--FLFFA--GWVVVMSLFVY 385
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
26-409 1.88e-29

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 118.15  E-value: 1.88e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:COG2814    14 ALALGAFLSGLGIGIVLPALPLIAA--DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIM 185
Cdd:COG2814    92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG-----WRWV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 186 IVSASIPAIILWINSfhivgsphWLLLKkrfkkarklfsklgfekstfdgieqESKTKSKKDDDISWKSILKKPSLVYLl 265
Cdd:COG2814   167 FLVNAVLALLALLLL--------LRLLP-------------------------ESRPAARARLRGSLRELLRRPRLLLL- 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 266 isgILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLAL 345
Cdd:COG2814   213 ---LLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLL 289
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 346 LGlvlrlslftqTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWI 409
Cdd:COG2814   290 LA----------LAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
24-449 3.11e-29

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 119.26  E-value: 3.11e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  24 TYIISIGG-FLFGYDTGVINGALAFMSK---------------PDQLNLtpgLQGVVSSSLVLGAFFGALGCGRIADKFG 87
Cdd:cd17432     2 TLAAAFGSsFQYGYNLSVVNSPTPYIQNfynetwterygtpleESTLTL---LWSLTVSIFPLGGLFGSLLVGPLVIRLG 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  88 RKQTLRWIAALFTSSTILCALSM---NFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSA 164
Cdd:cd17432    79 RKGTLLLNNIFAIVAAILMGLSKiakSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLG 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 165 --FCMNAFLGNIWGnwnpiWRIMIVSASIPAII-LWINSFhIVGSPHWLLLKKRFK-KARKLFSKLGFEKSTFDGIE--Q 238
Cdd:cd17432   159 qvLGLRELLGNEEG-----WPLLLALTGVPALLqLLTLPF-FPESPRYLLIEKGDEeAARKALQRLRGKEDVDDEMEemL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 239 ESKTKSKKDDDISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIF 318
Cdd:cd17432   233 EEQRAEKGVGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATIT 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 319 GTRLIARFDhHRMLLIGLFGnilflallglvlRLSLFTQTITNALVL------------IFLALFLASHQGIVSPVTWLI 386
Cdd:cd17432   313 CVLVIERLG-RRPLLIGGFG------------LMAVWCAVLTVALSLqntvswmpylsiVCIFAYIASFGIGPAGVPFIL 379
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 387 MSEMFPGKIK-ARFMsIATATTWITNFIISLIYPLLISAVGtAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17432   380 TTEIFDQSSRpAAFM-VAGSLNWLSNFLVGLLFPFIQEGLG-AYCFLVFAVICLLTAIYIFFVL 441
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
23-447 5.13e-24

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 103.80  E-value: 5.13e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  23 STYIISIGGFLFGYDTGVINGALAFMSK--PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFT 100
Cdd:cd17433     3 ATFAAVLGPLSFGFVLGYSSPAIPSLQRiaDPALRLDDAAASWFGSVVTLGAAAGGVLGGWIVDRAGRKLSLMLCSVPFI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 101 SSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGniwgnwnp 180
Cdd:cd17433    83 AGFTVITAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEIAHPRVRGTLGSCVQLMVVIGIMGAYLAGLVLD-------- 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 181 iWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKL-GFEKSTFD---GIEQESKTKSKKDDdiswKSIL 256
Cdd:cd17433   155 -WRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLrGPDQGWEWeciGIEQSFHLEEQSFS----LALL 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 257 KKPSLVYLLISGILIALIQQISGVNTVMYYGTILMEKVGMgQSGSLyANILIGLVSFVASIFGTRLIARFDhhRMLLIGL 336
Cdd:cd17433   230 KQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKF-KDSSV-ASVIVAAIQVLFTAVAALIMDRAG--RKVLLVL 305
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 337 FGNILFlallglvlrlslFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISL 416
Cdd:cd17433   306 SGVVMV------------FSTAAFGWLAVGSMGFFIAGFAVGWGPIPWLVMSEIFPLHVRGVASGICVLTNWLMAFLVTK 373
                         410       420       430
                  ....*....|....*....|....*....|.
gi 1130874348 417 IYPLLISAVGTAVVFFIFAASNGVSALLSIF 447
Cdd:cd17433   374 EFSSLMEVLSSYGTFWLFSAFCAFSVLFTLF 404
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
26-447 7.04e-22

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 96.52  E-value: 7.04e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKPDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:cd17316     3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIF----IVLGQLSAFCMNAFLGNIWGnwnpi 181
Cdd:cd17316    83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGwalgALLAALVASLLIPLLSGDWG----- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 182 WRIMIVSASIPAIILWInsfhivgsphwlllkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpsL 261
Cdd:cd17316   158 WRILFLIGALPALLALL--------------------------------------------------------------L 175
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 262 VYLLISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGnil 341
Cdd:cd17316   176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLIL--- 252
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 342 flALLGLVLRLSLFTQTITNALVLIFLALFLAshqGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLL 421
Cdd:cd17316   253 --SGILALPLFYLLSGSPTLLLLLLFILSFFV---GGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
                         410       420
                  ....*....|....*....|....*.
gi 1130874348 422 ISAVGTAVVFFIFAASNGVSALLSIF 447
Cdd:cd17316   328 LASTGGTGVPALILALLAIVALIVAL 353
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
26-223 2.44e-20

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 91.03  E-value: 2.44e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:COG0477    18 ALALGTFLEGLDFTIVNVALPSIAA--DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLL 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIM 185
Cdd:COG0477    96 CGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-----WRWI 170
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1130874348 186 IVSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLF 223
Cdd:COG0477   171 FLINAPLGLLALVLRLRLPESRGLLLALLALALAALLL 208
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
26-449 9.48e-20

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.31  E-value: 9.48e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:COG2271    14 LLFLAYFLNYLDRSNLSVAAPPLQA--DLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVnknAIFIVLGQLSAFCMNAFLGNIWGNWNpiWRIM 185
Cdd:COG2271    92 FGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRAL---GIFNAGGPLGGALAPPLLGWLLAAFG--WRAA 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 186 IVSASIPAIILWINSFhivgsphWLLlkkrfkkarklfsklgfekstfdgieqesktkskkdddiswksilkkpSLVYLL 265
Cdd:COG2271   167 FLILGLPGLLLALLRF-------WLL------------------------------------------------ALAYFL 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 266 ISGILIALIqqisgvntvMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFgnilflaL 345
Cdd:COG2271   192 VYFALYGFL---------TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG-------L 255
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 346 LGLVLRLSLFTQTITNALVLIFLALFLASHQGIvSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAV 425
Cdd:COG2271   256 LLAALALLLLALLPSPALAIALLFLAGFGLGGA-FGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDAT 334
                         410       420
                  ....*....|....*....|....
gi 1130874348 426 GTAVVFFIFAASNGVSALLSIFVL 449
Cdd:COG2271   335 GYQAAFLLLAALALLAALLALLLL 358
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
27-447 3.61e-18

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 85.94  E-value: 3.61e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  27 ISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQ--SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNwnpIWRIMI 186
Cdd:cd06174    79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGF---GWRAVF 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 187 VSASIPAIILWINSFHIVGSPHWlllkkrfkkarklfsklgfekstfdGIEQESKTKSKKDDDISWKSILKKPSLVYLLI 266
Cdd:cd06174   156 LIAAALALLAAILLLLVVPDPPE-------------------------SARAKNEEASSKSVLKLLKRVLKNPGLWLLLL 210
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 267 sgilIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGnilflall 346
Cdd:cd06174   211 ----AIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLL-------- 278
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 347 gLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVG 426
Cdd:cd06174   279 -LMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF 357
                         410       420
                  ....*....|....*....|.
gi 1130874348 427 TAVVFFIFAASNGVSALLSIF 447
Cdd:cd06174   358 GLTGAFLVLAVLLLLAAILLL 378
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
29-449 2.00e-16

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 80.62  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  29 IGGFLFGYDTGVINGALAFMSKPDQLNLTPglQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCAL 108
Cdd:cd17436     8 LGGLTFGYELGIISGALLQLQTDFSLSCFE--QEALVSALLIGALLASLIGGFLIDRHGRRTSILGSNLVLLAGSLILTL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 109 SMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNI-WGnwnpiWRIMIV 187
Cdd:cd17436    86 AGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISYALNYFFSNVlTG-----WRYMFG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 188 SASIPAIILWINSFHIVGSPHWLLLKkrfkkarklfsklgfekstfdgieqesktkskkdDDISWKSILkkpslvyllis 267
Cdd:cd17436   161 LAIIPAAIQFASILLLPKKPEVLNIK----------------------------------DNMRRRTLV----------- 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 268 GILIALIQQISGVNTVMYYGTILMEKVGM-GQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGlfgnilflall 346
Cdd:cd17436   196 GLGLVLFQQFTGQPNVLCYASTIFRSVGFqSNSSAVLASVGLGVVKVIATLLAMLFADRAGRRSLLIAG----------- 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 347 glvlrlslfTQTITNALVLIFLALFLASHQGIVS-------PVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYP 419
Cdd:cd17436   265 ---------CSVMAVSVSGIGLWITLLCLMAFVSafsigfgPMTWLVLSEIYPADIRGRAFSFCNSFNWAANLLITLSFL 335
                         410       420       430
                  ....*....|....*....|....*....|
gi 1130874348 420 LLISAVGTAVVFFIFAASnGVSALLSIFVL 449
Cdd:cd17436   336 DLIDVIGLSWTFLLYGVV-GVAGVVFIYLF 364
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
29-447 2.28e-16

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 81.03  E-value: 2.28e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  29 IGGFLFGYDTGVINGALAFMSKPDQ--LNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd17434     9 LGNFSFGYALVYTSPVIPALEQGDDprLHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSIMFSAVPSALGYLLM 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGniwgnwnpiWRIMI 186
Cdd:cd17434    89 GSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGLLLP---------WRWLA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 187 VSASIPAIILWINSFHIVGSPHWLLLKKRFKKARKLFSKLGFEKSTFDG-IEQESKTKSKKDDDISWkSILKKPSLVYLL 265
Cdd:cd17434   160 VAGEVPVVIMILLLCFMPNSPRFLISKGKDEKALKALAWLRGPNTDYMTeFEQIKDNIRKQSSRLSW-AELKTPSYYKPI 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 266 ISGILIALIQQISGVNTVMYYGTILMEKVGMGQSGSlYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFgnilflal 345
Cdd:cd17434   239 LIAVVMRFLQQLTGITPILVYLEPIFHLTAVILEPK-YDAALVGAVRLLSVAIAASLMDKAGRKILLFTSAF-------- 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 346 lglvlrlSLFTQTITNALV-LIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISA 424
Cdd:cd17434   310 -------LMFAANLSMGLIpLIAAMLFIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITAFVLTQLFLPVVVT 382
                         410       420
                  ....*....|....*....|...
gi 1130874348 425 VGTAVVFFIFAASNGVSALLSIF 447
Cdd:cd17434   383 FGLQVPFLFFAAVCAVSIIFTAC 405
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
23-397 1.59e-15

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 78.17  E-value: 1.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  23 STYIISIGGFLF-GYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTS 101
Cdd:TIGR00895  17 RAIILSFLIMLMdGYDLAAMGFAAPAISA--EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSV 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 102 STILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpi 181
Cdd:TIGR00895  95 FTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG----- 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 182 WRIM-IVSASIPAIILWINSFHIVGSPHWlLLKKRFKKARKLFSKLGFEKstfdGIEQESKTKSKKDDDISWKSILKkps 260
Cdd:TIGR00895 170 WRSLfYVGGIAPLLLLLLLMRFLPESIDF-LVSKRPETVRRIVNAIAPQM----QAEAQSALPEQKSTQGTKRSVFK--- 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 261 lvyLLISGILIA---LIQQISGVNTVMYYG-TILMEKVGMGQSGSLYANILIGLVSFVASIFGT----RLIARFDHHRML 332
Cdd:TIGR00895 242 ---ALFQGKTARitvLLWLLYFMLLVGVYFlTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSiifgWLADRLGPRVTA 318
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1130874348 333 LIGLFGNILFLALLGLVLrlslftqTITNALVLIFLALFLASHQGIVSPVtwlIMSEMFPGKIKA 397
Cdd:TIGR00895 319 LLLLLGAVFAVLVGSTLF-------SPTLLLLLGAIAGFFVNGGQSGLYA---LMALFYPTAIRA 373
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
59-326 3.50e-15

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 77.75  E-value: 3.50e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  59 GLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLA 138
Cdd:TIGR00898 127 WKVDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWVQAVVLNT 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 139 EISPEPVRtinvnknAIFIVLGQlSAFCMNAFLGNIWGNWNPIWRIMIVSASIPAIILWINSFHIVGSPHWLLLKKRFKK 218
Cdd:TIGR00898 207 EFLPKKQR-------AIVGTLIQ-VFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEE 278
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 219 ARKLFSKLGFEKST------FDGIEQESKTKSKKDDdiSWKSILKKPSLVYLLISGILIALIqqisgvNTVMYYGTIL-M 291
Cdd:TIGR00898 279 ALKILQRIAKINGKklpaevLSLSLEKDLSSSKKQY--SFLDLFRTPNLRKTTLCLMMLWFT------TAFSYYGLVLdL 350
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1130874348 292 EKVGmgqsGSLYANILI-GLVSFVASIFGTRLIARF 326
Cdd:TIGR00898 351 GNLG----GNIYLDLFIsGLVELPAKLITLLLIDRL 382
MFS_1 pfam07690
Major Facilitator Superfamily;
27-413 1.21e-14

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 74.76  E-value: 1.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  27 ISIGGFLFGYDTGVINGALAFMSKpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLA-EDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIMI 186
Cdd:pfam07690  80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-----WRAAF 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 187 VSASIPAIILWInsfhivgspHWLLLKKRFKKARKlfsklgfekstfdgieqESKTKSKKDDDISWKSILKKPSLVylli 266
Cdd:pfam07690 155 LILAILSLLAAV---------LLLLPRPPPESKRP-----------------KPAEEARLSLIVAWKALLRDPVLW---- 204
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 267 sgILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNIlflall 346
Cdd:pfam07690 205 --LLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLI------ 276
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1130874348 347 gLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFI 413
Cdd:pfam07690 277 -LAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGAL 342
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
24-446 1.65e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 74.89  E-value: 1.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  24 TYIISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSST 103
Cdd:cd17324     1 LLALALAAFAIGTTEYVIQGLLPDIAR--DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 104 ILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWR 183
Cdd:cd17324    79 LLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-----WR 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 184 I-MIVSASIPAIILWINsfhivgsphWLLLKKRFKKARKLFSKLGfekstfdgieqesktkskkdddiSWKSILKKPSLV 262
Cdd:cd17324   154 AaFLAIAVLALLAALLL---------WRLLPSLPPKKPGSLGLLS-----------------------SLLLLLRNPRLR 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 263 YLLISGILIaliqqISGVNTVM-YYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFgnil 341
Cdd:cd17324   202 LAYLITFLL-----FGGFFALYtYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLL---- 272
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 342 flallgLVLRLSLFTQTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKiKARFMSIATATTWITNFIISLIYPLL 421
Cdd:cd17324   273 ------LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA-RGLASSLYLAAYNLGGALGAALGGLV 345
                         410       420
                  ....*....|....*....|....*
gi 1130874348 422 ISAVGTAVVFFIFAASNGVSALLSI 446
Cdd:cd17324   346 LDHGGWAGVGWVGAALLLLALLLAL 370
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
52-446 1.34e-13

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 71.95  E-value: 1.34e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  52 DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASS 131
Cdd:cd17371    27 AEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWA 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 132 LSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGNWNPiWRIMIVSASIPAIILWINSFHIVGSPHWll 211
Cdd:cd17371   107 AGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEIA-WRVLFLLGALPALLVLFIRRFVKEPPQW-- 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 212 lkkrfkkarklfsklgfekstfdgieQESKTKSKKDDDISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYGTILM 291
Cdd:cd17371   184 --------------------------QAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLT 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 292 EKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNIlflallGLVLRLSLFTQTITNALVLIFLALF 371
Cdd:cd17371   238 GERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSA------ISILLYFFLPLSPTLILILGFPLGF 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 372 LAShqGIVSpVTWLIMSEMFPGKIKARfmsiATATTWITNFIISLIYPLLISAVGT-------AVVFFIFAASNGVSALL 444
Cdd:cd17371   312 FAS--GPFS-GMGAYLTELFPTAVRAT----AQGFCYNVGRIIGALFPFLVGFLATsgslgtaIAVFAAVYYIAGLVLAL 384

                  ..
gi 1130874348 445 SI 446
Cdd:cd17371   385 LL 386
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-448 1.10e-12

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 69.50  E-value: 1.10e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  16 NNSFLKYSTYIISIGGFLFGYDTGVINGALAFMSkpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWI 95
Cdd:COG0738     2 SKKNYRRALIAIYLLFFLWGFATALWGPLIPALK--DAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  96 AALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFlgnIW 175
Cdd:COG0738    80 LLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLL---IL 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 176 GNWNPIWRIMIVSASIPAIILWInsfhivgsphwLLLKKRFKkarklfsklgfekstfdgiEQESKTKSKKDDDISWKSI 255
Cdd:COG0738   157 LGLSLSWHLPYLILAVLLLLLAL-----------LFLRSKLP-------------------EIEEEEEEAAGSAASLKSL 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 256 LKKPSLVYLLISGILIALIQQISGVNTVMYygtiLMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIG 335
Cdd:COG0738   207 LKNPRLLLGGLAIFLYVGAEGAIGDWLPLY----LKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLS 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 336 LFGNIlflallGLVLRLSLFTQTITNALVLIFLALFLAshqgIVSPVTWLIMSEMFpGKIKARFMSIATATTWITNFIIS 415
Cdd:COG0738   283 ALLAA------VGLLLALLAPGPWLALIGLALVGLGLS----LMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGP 351
                         410       420       430
                  ....*....|....*....|....*....|...
gi 1130874348 416 LIYPLLISAVGTAVVFFIFAASNGVSALLSIFV 448
Cdd:COG0738   352 PLIGFLADAFGLRAAFLVPLVCYLLILLLALAL 384
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
51-448 5.59e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 67.21  E-value: 5.59e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  51 PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAAS 130
Cdd:COG2223    32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSF 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 131 SLSPMYLAEISPEPVR-TINvnknAIFIVLGQLSAFCMNAFLGNIWGNWNpiWRIMIVSASIPAIILWInsfhivgsPHW 209
Cdd:COG2223   112 AVGIALVSKWFPPDRRgLAL----GLAAGGGNLGAAVAAFLAPLLIAAFG--WRNAFLILGILLLVVAV--------LAW 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 210 LLLKKRfkkarklfsklgfekstfdgieQESKTKSKKDDDISWKSILKKP-----SLVYLLISGILIALIQQISgvntvm 284
Cdd:COG2223   178 LFLRDP----------------------PAGAAAAAKASLRDQLEALRDPrfwllSLLYFGTFGSFIGFSSWLP------ 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 285 yygTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLALlglvlrlslFTQTITNALV 364
Cdd:COG2223   230 ---PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL---------LALALGSLWL 297
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 365 LIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGT-AVVFFIFAASNGVSAL 443
Cdd:COG2223   298 FLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAVLALVALV 377

                  ....*
gi 1130874348 444 LSIFV 448
Cdd:COG2223   378 LTLLL 382
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
35-196 6.11e-12

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 66.84  E-value: 6.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  35 GYDTGVInGALAFMSKPDqLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLF 114
Cdd:cd17365    12 GFDLAVM-GFVAPALAQD-WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 115 MSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIMIVSASIPAI 194
Cdd:cd17365    90 LALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-----WRSVFLLGGVPPL 164

                  ..
gi 1130874348 195 IL 196
Cdd:cd17365   165 IL 166
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
27-447 1.15e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 66.06  E-value: 1.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  27 ISIGGFLFGYDTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLYAE--SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAfcmnAFLGNIWGNWNPIWRIMI 186
Cdd:cd17325    79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIG----PLLGGLLADALGYRAPFL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 187 VSASIPAIILWINsfhivgsphWLLLKKRFKkarklfsklgfekstfdgiEQESKTKSKKDDDISWKSILKKPSLVYLLI 266
Cdd:cd17325   155 VCAALALLALVLA---------LLLLPEPRP-------------------PPNKRAVSAARLRSGLRLLLRDRRLLALFL 206
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 267 SGILIALIQQISGVNTVMYygtiLMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLALL 346
Cdd:cd17325   207 AIFVLAFAFGALEPFLPLY----AAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLL 282
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 347 GLVlrlslftqtiTNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVG 426
Cdd:cd17325   283 PLA----------TSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG 352
                         410       420
                  ....*....|....*....|.
gi 1130874348 427 TAVVFFIFAASNGVSALLSIF 447
Cdd:cd17325   353 FATPFLAAAALLLLAAVLFLL 373
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
30-448 7.14e-11

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 63.84  E-value: 7.14e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  30 GGFLFGYDTGVINGALAFMSK---PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd17364     7 GFFTDAYDLFSISLVTKILGRlyyGGKGSLPSGVSGLVNAAALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 107 ALSMN------FLFMSFFRFALGLSVGAASSLSPMYLAEISpepvrtiNVNKNAIFIV-------LGQL---------SA 164
Cdd:cd17364    87 ALSPGstplgvMGWLIFFRFLLGIGIGGDYPLSATIMSEYA-------NKKRRGALIAavfamqgFGILagaivtlilSA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 165 FCMNAFLGNIWGNWNPIWRIMIVSASIPAIILWINSFHIVGSP-HWLLLkkrfkkarklfsklgfekstfdgieqesktk 243
Cdd:cd17364   160 IFEHPLPAGTYHHADLVWRIVLGLGAIPALSVLYFRKHLLGTAgTWFLL------------------------------- 208
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 244 skkddDISWKSIlkkpslvyLLISGILIALIQQISGVNTvmyygTILMEKVGMGQsgslyaNILIGLVSFVASIFGTRLI 323
Cdd:cd17364   209 -----DIAFYGQ--------NLFQSTIISAIGFSKTMNA-----YQELFNIAVGQ------LIIALAGTVPGYWFTVFLI 264
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 324 ARFDHHRMLLIGLFGnilFLALLGLVLRLSLFTQTITNALVLIFLALFLASHQGIVSpVTWLIMSEMFPGKIKARFMSIA 403
Cdd:cd17364   265 DRIGRKKIQMMGFFG---MTIFLLILAGPYDHWKISTIGFFVLYGLTFFFSNFGPNT-TTFIVPAEVFPARVRSTCHGIS 340
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1130874348 404 TATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSIFV 448
Cdd:cd17364   341 AASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLF 385
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
27-147 5.90e-10

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 60.65  E-value: 5.90e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  27 ISIGGFLFGYDTGVINGALAFMSkpDQLNLTPG-LQGVVSS-SLVLGAFfgALGCGRIADKFGRKQTLRWIAALFTSSTI 104
Cdd:cd17321     1 LLLAVFLAALDVTIVNVALPTIA--RDLGASPSqLQWVVNAyLLAFAAL--LLLAGRLGDRFGRKRVFLIGLALFGLASL 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1130874348 105 LCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRT 147
Cdd:cd17321    77 LCALAPSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRG 119
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
31-449 9.70e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.81  E-value: 9.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  31 GFLFGY-DTGVINGALAFMSKpdQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALS 109
Cdd:cd17319    11 AYVINYlDRVNISVAAPTIMK--DLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 110 MNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTInvnKNAIFIVLGQLSAFCMNAFLGNIWGNWNpiWRIMIVSA 189
Cdd:cd17319    89 TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGR---ATGLFNSGAPLGAAIGPPLSGWLLLLFG--WRWAFIIE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 190 SIPAIILwinsfhivgSPHWLLLKKRFkkarklfskLGFekstfdgieqesktkskkdddiswksilkkpSLVYLLISGI 269
Cdd:cd17319   164 GLLGLLL---------AVLWWFYLRQV---------WGL-------------------------------ALGYFGINYA 194
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 270 LIALIQqisgvntvmYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHR---MLLIGLFGnilflalL 346
Cdd:cd17319   195 LYGLLT---------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGArrlVIIIGLLL-------A 258
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 347 GLVLRLSLFTQTITNALVLIFLALFLAshqGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVG 426
Cdd:cd17319   259 AVGLLLAYLTTSPVVAVILLSLAGFGI---GAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATG 335
                         410       420
                  ....*....|....*....|...
gi 1130874348 427 TAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17319   336 SYTAAFLFLAAVALLAALLVLLL 358
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
68-449 2.35e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 55.66  E-value: 2.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  68 LVLGAFFGALGC-----GRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISP 142
Cdd:cd17320    38 LTLSAYLLGFALgqllyGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 143 EPVRT-INVNKNAIFIV-------LGQLSAFcmnaflgniWGNWNPIWRIMIVSASIPAIILWinsfhivgsphWLLLKK 214
Cdd:cd17320   118 GAELAkIFSLLMMILAIapalaplLGGLLLL---------FFGWRAIFVFLALLGLLLLLLVL-----------LFLPET 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 215 RFKKARKLFSKLGFEkstfdgieqesktkskkdddiSWKSILKKPS-LVYLLISGILIALIQQISGVNTVmyygtILMEK 293
Cdd:cd17320   178 LPEEKRKPLLSSLLR---------------------AYKRVLKNRRfLGYALALGLSFAGLFAYLAAAPF-----IYIEQ 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 294 VGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNIlflaLLGLVLRLSLFTQTITNALVLIFLALFLA 373
Cdd:cd17320   232 LGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLL----AAALVLLLAALLGGLSLWPLVAPLFLIFF 307
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1130874348 374 SHqGIVSPVTWLIMSEMFPGKIkarfmSIATATTWITNFIISLIYPLLISAV--GTAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17320   308 GF-GLIFPNATSLALEPFPHVA-----GTASALLGFLQFLIGALAGALVGLLpnGTALPMGLLILVLGLLALLLLILL 379
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
60-196 1.06e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 53.74  E-value: 1.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  60 LQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAE 139
Cdd:cd17317    26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGME 105
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1130874348 140 ISPEPVRTINVNKNAIFIVLGqlsaFCMNAFLGNIWGNwnpiWRIMIVSASIPAIIL 196
Cdd:cd17317   106 IVGPKYRSFVGILFGLFWALG----YMLLALLAYLIRD----WRWLQLAISLPGLLF 154
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
59-200 5.53e-07

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 51.52  E-value: 5.53e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  59 GLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSV-GAASSLSPMYL 137
Cdd:cd17374    35 SLKSVAQSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVsGISINTLILGT 114
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1130874348 138 AEISPEpvrtinvnKNAIFIVLGQLSAFCMNAFLGNIwGNWNPIWRIMIVSASIPAIILWINS 200
Cdd:cd17374   115 EWTTPR--------HRALAITLTSCFFSIGQMLLAGL-AYAIRDWRLLQLVVSVPFFLFFLYS 168
PRK03893 PRK03893
putative sialic acid transporter; Provisional
29-197 5.54e-07

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 52.01  E-value: 5.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  29 IGGFLFGYDTGVIngALAFMSKPDQLNLTPglqgVVSSSLVLGAF----FGALGCGRIADKFGRKQTLRWIAALFTSSTI 104
Cdd:PRK03893   27 LGYLLDGFDFVLI--TLVLTEVQGEFGLTT----VQAASLISAAFisrwFGGLLLGAMGDRYGRRLAMVISIVLFSVGTL 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 105 LCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRtinvNKNAIFIV----LGQLSAFCMNAFLGNIWGnwnp 180
Cdd:PRK03893  101 ACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLR----NKASGFLIsgfsIGAVVAAQVYSLVVPVWG---- 172
                         170
                  ....*....|....*..
gi 1130874348 181 iWRIMIVSASIPAIILW 197
Cdd:PRK03893  173 -WRALFFIGILPIIFAL 188
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
22-198 1.59e-06

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  22 YSTYIISIGGFLFGYdtgVINGALAFMSK--PDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGR--KQTLRWIAA 97
Cdd:COG2271   180 LRFWLLALAYFLVYF---ALYGFLTWLPTylVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLL 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  98 LFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTINVnknAIFIVLGQLSAFCMNAFLGNI--W 175
Cdd:COG2271   257 LAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS---GLVNTFGFLGGALGPLLVGYLldA 333
                         170       180
                  ....*....|....*....|...
gi 1130874348 176 GNWNPIWRIMIVSASIPAIILWI 198
Cdd:COG2271   334 TGYQAAFLLLAALALLAALLALL 356
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
53-196 2.28e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 49.51  E-value: 2.28e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  53 QLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSL 132
Cdd:cd17489    25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 133 SPMYLAEISPEPVRTINVNKNAIFIVLGQlsafCMNAFLGNIWGNWNPIWRIMIVSASIPAIIL 196
Cdd:cd17489   105 AATLVADIIPPSRRGEGIGYYGLATTLAM----ALGPALGLFLYQHLGFAVLFIVAAVLALLAL 164
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
251-457 7.45e-06

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 48.23  E-value: 7.45e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 251 SWKSILKKPSLVYLLISGILIaliqqISGVNTVMYYGTILMEKV-GMGQSGSLYANILIGLVSFVASIFGTRLIARFDHH 329
Cdd:COG2270   230 TLRELRRYRDLLRFLLAYFFY-----RDGVQTVIAFAGIYAAGVlGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPK 304
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 330 RMLLIGLFGNILFLALLGlvlrlslftqTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWI 409
Cdd:COG2270   305 RVILVSLVIWIVVCLAAY----------FLTTALAFWILGLLIGLVMGGIQALSRSLLARLIPPGREAEFFGLYALSGKA 374
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1130874348 410 TNFIISLIYPLLISAVGTA-------VVFFIfaasngVSALLSIFVLNAKEIQRA 457
Cdd:COG2270   375 ASFLGPLLFGLVTQLTGSQrlgilslIVFFV------IGLVLLLRVKVPRGRAAA 423
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
54-129 8.64e-06

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 48.03  E-value: 8.64e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1130874348  54 LNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAA 129
Cdd:PRK11551   45 FGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGVGLGGA 120
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
28-128 1.12e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 47.57  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  28 SIGGFLFGYDTGVINGALAFMskPDQLNLTPGLQG-VVSSSLVLGAFFGALgCGRIADKFGRKQTLRWIAALFTSSTILC 106
Cdd:cd17504     2 ALAALAVMLVETMLSPALPTI--QREFGTSAAAVSwVLTAYLLVGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLA 78
                          90       100
                  ....*....|....*....|..
gi 1130874348 107 ALSMNFLFMSFFRFALGLSVGA 128
Cdd:cd17504    79 AFAPNLPVLIAGRALQGIGGAV 100
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
269-449 2.24e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 46.51  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 269 ILIALIQQISGVNTVMYYGTI--LMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLALL 346
Cdd:COG2814    13 LALALGAFLSGLGIGIVLPALplIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 347 GlvlrlslftqTITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVG 426
Cdd:COG2814    93 A----------LAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
                         170       180
                  ....*....|....*....|...
gi 1130874348 427 TAVVFFIFAASNGVSALLSIFVL 449
Cdd:COG2814   163 WRWVFLVNAVLALLALLLLLRLL 185
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
26-143 1.28e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.12  E-value: 1.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:COG2211   232 LLLLAYLLFFLALALVAALLLYYFK-YVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLL 310
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1130874348 106 CALS--MNFLFMSFFRFALGLSVGAASSLSPMYLAEISPE 143
Cdd:COG2211   311 LFFLgpGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
66-124 3.15e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 42.72  E-value: 3.15e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1130874348  66 SSLVLGAFFGALGCGRIADKFGRKQTLrwIAALFTS--STILCALSMNFLFMSFFRFALGL 124
Cdd:cd17379    40 SSLNLGFLIGSIVIGYLADRFGRKVCF--LISILGNgvSGVLMAFSPNYPWFLIFRFLQGL 98
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
60-198 3.28e-04

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 42.73  E-value: 3.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  60 LQGVVSSSLVLGAFFGALGCGRIAD-KFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLA 138
Cdd:cd17378    34 LVGLPQSSFFVGCLIGSGVLGHLADsSLGRKNLLFLSCLLMALSGIATAFSPNYWVYAFLRFLTGFGRSGIGTCALVLAT 113
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 139 EISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNiwgnwnpIWRIMIVSASIPAIILWI 198
Cdd:cd17378   114 EPVGPKWRGQVGMSTFFFFVLGFMSLPGIAYLNGS-------SWRVLYFWTSIPALIYCI 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
251-449 3.55e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 42.97  E-value: 3.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 251 SWKSILKKPSLVYLLISGILIALIQQISGVnTVMYYGTILMekvGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHR 330
Cdd:COG2211   220 SLKALLKNRPFLLLLLAYLLFFLALALVAA-LLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKK 295
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 331 MLLIGLFGNILFLALLGLVLRlslftqtiTNALVLIFLALFLASHQGIVSPVTWLIMSEMFP-------GKIKARFMSIA 403
Cdd:COG2211   296 AFIIGLLLAALGLLLLFFLGP--------GNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIF 367
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1130874348 404 TATTWITNFIISLIYPLLISAVGtavvfFIFAASNGVSALLSIFVL 449
Cdd:COG2211   368 TFAIKLGQALAGALAGLLLALFG-----YVAGAAQSPSALTGIRLL 408
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
52-446 3.70e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 42.60  E-value: 3.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  52 DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLfmSFFRFALGLSVGAASS 131
Cdd:cd17329    28 QQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPW--LFAIALVLTGFGGGLF 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 132 LSPMY--LAEISPEPVRTinvNKNAIFIVLGQLSAFCmNAFLGNIWGNWNPIWRIMIVSASipaiilwinsFHIVGSPHW 209
Cdd:cd17329   106 EPASEamIADVTTPENRT---RAFSLLYWAINLGVAI-GPLLGGLLLLYSFRLLFLAAAVL----------FLLAALVLL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 210 LLLKKRFKKARKLFSKLGFEkstfdgieqesktkskkdddiSWKSILKKPSLVYLLISGILIALI-QQISGvntvmYYGT 288
Cdd:cd17329   172 FLLPETRPKRRAAEKTEILR---------------------GYKIVLRDRAFLLFLLASFLISLIyFQLES-----TLPV 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 289 ILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFgnilflallgLVLRLSLFTQTITNALVLIFL 368
Cdd:cd17329   226 YVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGIL----------LFAIGFAVLAFANTLAVLILA 295
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1130874348 369 ALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSI 446
Cdd:cd17329   296 MIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLL 373
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
70-449 3.89e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 3.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  70 LGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTIN 149
Cdd:cd17473    46 LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKM 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 150 VNKNAIFIVLGQLSAFCMNAFLGNIwgNWNPIWRIMIVSasIPAIILwinsfhivgspHWLLLKKRFKKArklfsklgfe 229
Cdd:cd17473   126 LGLQSAAMSLGGVVFLLLGGALAEI--GWRAPFLVYLLA--LPVLIL-----------VLLFLPEPARKS---------- 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 230 kstfdgiEQESKTKSKKDDDISWKSILkkPSLVYLLISGILIALIqqisgvntVMYYGTILMEKVGMGQSGSLYANILIG 309
Cdd:cd17473   181 -------KSAASPGAATAAALPWKRVL--PIYFLAFLAMLLFYVI--------PIQLPFLLQERGGGSAALIGLALAIAS 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 310 LVSFVASIFGTRLIARFDHHRMLLIGLFgnilflallglVLRLSLFTQTITNALVLIFLALFLAS-HQGIVSPVTWLIMS 388
Cdd:cd17473   244 LAGAIGALLFGRLKRRLGKRRLLAIGFA-----------LMALGFLLLALASGLWVVLLGAILAGlGFGLLLPTLNSWAM 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1130874348 389 EMFPGKIKARFMSIATATTWITNFIISLI-YPLLISAVGTAVVFFIFAASNGVSALLSIFVL 449
Cdd:cd17473   313 SLVPPELRGRAMGIVTSAFFLGQFLSPLVlGPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
52-436 5.58e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.17  E-value: 5.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  52 DQLNLTPGLQG-VVSSSLVLGAFFGALGcGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAAS 130
Cdd:cd17474    27 EALGASPAQVGlLITAFTLPAAVLMPVA-GVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGLG 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 131 SLSPMYLAEISPEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWgnwnpiWRI--MIVSASIPaIILWINSFhivgsph 208
Cdd:cd17474   106 PLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAIS------WRYpfFLLAALIP-VAFLAILF------- 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 209 wlLLKKrfkkarklfsklgfekstfdgiEQESKTKSKKDDDISWKSILKKPSLVYLLISGILIALiqqisGVNTVMYYGT 288
Cdd:cd17474   172 --LLPE----------------------PKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFF-----LYFAFLTYLP 222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 289 ILMEKVGM---GQSGSLYANILIGLVsFVASIFGTRLIARFDHHRMLLIGLFGNILFLALLGlvlrlslftqtITNALVL 365
Cdd:cd17474   223 FLLELLYGispIIIGLLFAGWSVLLA-LGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLG-----------FVPSLAL 290
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1130874348 366 IFLALFLAS-HQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAA 436
Cdd:cd17474   291 LLIAIVLFGlGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAA 362
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
53-447 5.74e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.22  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  53 QLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCAL-----SMNFLFMSFFRFALGLSVG 127
Cdd:cd06173    28 QLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALlallgSLSLWLLLVLAFLLGIASA 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 128 AASSLSPMYLAEISPEPVRtinVNKNAIFIVLGQLSAFCMNAFLGNIWGNWNPIWRIMIVSASIPAIILWInsfhivgsp 207
Cdd:cd06173   108 FFGPARQALLPELVPKEQL---VRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLL--------- 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 208 hwLLLKKRFKKARKlfsklgfekstfdgieqESKTKSKKDDDISWKSILKKPSLVYLLISGILIALIQQISGVNTVMYYG 287
Cdd:cd06173   176 --LFIRRPPPAAPG-----------------ESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAK 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 288 TILmekvGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGnilflallglvLRLSLFTQTITNALVLIF 367
Cdd:cd06173   237 EVL----GGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALL-----------LGLALLVLGLSPSLWLLL 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 368 LALFLASHQGIVSPVTWL-IMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSI 446
Cdd:cd06173   302 AALFLLGLAGGLFNVPLNtLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLL 381

                  .
gi 1130874348 447 F 447
Cdd:cd06173   382 L 382
MFS_1 pfam07690
Major Facilitator Superfamily;
269-456 7.58e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 7.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 269 ILIALIQQISGVNTVMYYGTILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLALLGL 348
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 349 vlrlslftqtITNALVLIFLALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTA 428
Cdd:pfam07690  82 ----------ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
                         170       180
                  ....*....|....*....|....*...
gi 1130874348 429 VVFFIFAASNGVSALLSIFVLNAKEIQR 456
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPRPPPESKR 179
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
53-149 7.78e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 7.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  53 QLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLrwIAALFTS--STILCALSMNFLFMSFFRFALGLSvGAAS 130
Cdd:cd17330    28 KLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVL--LLSLAGSavSYVLLGLSRNLWLLFLARFLDGLT-GGNV 104
                          90
                  ....*....|....*....
gi 1130874348 131 SLSPMYLAEISPEPVRTIN 149
Cdd:cd17330   105 SVAQAYIADITDEEERAKA 123
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
79-142 9.68e-04

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 41.41  E-value: 9.68e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348  79 CGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISP 142
Cdd:cd17503    51 SGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYP 114
PRK12307 PRK12307
MFS transporter;
71-160 1.64e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 40.68  E-value: 1.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  71 GAFFGALgcgriADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVRTinv 150
Cdd:PRK12307   70 GALFGLL-----ADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKS--- 141
                          90
                  ....*....|
gi 1130874348 151 nKNAIFIVLG 160
Cdd:PRK12307  142 -KASAFLVSG 150
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
26-162 2.17e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 40.29  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  26 IISIGGFLFGYDTGVINGALAFMSKpDQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTIL 105
Cdd:cd06173   212 LLLLALALFALLGGALTVLLPLLAK-EVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV 290
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1130874348 106 CALSMNFLFMSFFRFALGLSVGAASSLSPMYLAEISPEPVR----TINVNKNAIFIVLGQL 162
Cdd:cd06173   291 LGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRgrvfSVYNALNSGAMPLGAL 351
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
297-450 2.29e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 40.25  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 297 GQSGSLYAniLIGLVSFVASIFGTRLIARFDHHRMLLIGLFgnilflallgLVLRLSLFTQTITNALVLIFLALFLASHQ 376
Cdd:COG2223    40 AQLGLLFA--IPVLVGALLRIPLGFLVDRFGPRRVLLIGLL----------LLGIGLLLLALAVSYWLLLLLGLLLGIGG 107
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1130874348 377 GIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSIFVLN 450
Cdd:COG2223   108 GGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLR 181
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
63-196 3.52e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 39.44  E-value: 3.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  63 VVSSSLVLGAFFGALGCGRIADKFGRKQTLRwIAALFTS-STILCALSMNFLFMSFFRFALGLSVGAASSLSPMYlAEIS 141
Cdd:cd17372    38 LITSVVFAGMMIGSYLWGIVSDKYGRRKGLI-ISALWTFyAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWY-LEFL 115
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1130874348 142 PEPVRTINVNKNAIFIVLGQLSAFCMNAFLGNIWGnwnpiWRIMIVSASIPAIIL 196
Cdd:cd17372   116 PAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-----WRWLLAFSSVPSSLL 165
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
52-161 4.20e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 39.08  E-value: 4.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  52 DQLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASS 131
Cdd:cd17477    24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
                          90       100       110
                  ....*....|....*....|....*....|
gi 1130874348 132 LSPMYLAEISPEPVRTINVNKNAIFIVLGQ 161
Cdd:cd17477   104 VSESWLNALATNENRGRVLGLYSTVLGLGF 133
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
53-198 4.60e-03

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 39.09  E-value: 4.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  53 QLNLTPGLQGVVSSSLVLGAFFGALGCGRIADKFGRKqtlRWIAALFTSSTILCALSMNFLFMSFFRFA---LGLSVGAA 129
Cdd:COG2807   244 DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR---RPLLLLLGLLGLAGLLGLLLAPGSLPWLWavlLGLGQGGL 320
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1130874348 130 SSLSPMYLAEISPEPVRTINVnkNAIFIVLGQLSAFCMNAFLG---NIWGNWNPIWRIMIVSASIPAIILWI 198
Cdd:COG2807   321 FPLALTLIGLRARTPAEAAAL--SGMAQSVGYLLAALGPLLVGalhDATGSWTAALLLLAALAVLMLVAGLL 390
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
70-143 6.23e-03

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 38.98  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  70 LGAFFGALGCGRIADKFGRKQTLRW---------IAALFTSSTILcalsmnFLFMSffrFALGLSVGAASSLSPMYLAEI 140
Cdd:COG2270   285 IVAALGALLFGRLDDRIGPKRVILVslviwivvcLAAYFLTTALA------FWILG---LLIGLVMGGIQALSRSLLARL 355

                  ...
gi 1130874348 141 SPE 143
Cdd:COG2270   356 IPP 358
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
61-149 6.75e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.69  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  61 QGVVSSSLVLGAF-----FGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFrFALGLSVGAASSLSPM 135
Cdd:cd17478   227 YSLVFAGLLLSLFlfagaIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILL-VLAGFLLFASFPVTVV 305
                          90
                  ....*....|....
gi 1130874348 136 YLAEISPEPVRTIN 149
Cdd:cd17478   306 LAQELLPGNVGLAS 319
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
289-468 7.92e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 38.33  E-value: 7.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 289 ILMEKVGMGQSGSLYANILIGLVSFVASIFGTRLIARFDHHRMLLIGLFGNILFLALLGLvlrlslftqtITNALVLIFL 368
Cdd:cd17325    21 LYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF----------ATSYWQLLLA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348 369 ALFLASHQGIVSPVTWLIMSEMFPGKIKARFMSIATATTWITNFIISLIYPLLISAVGTAVVFFIFAASNGVSALLSIFV 448
Cdd:cd17325    91 RFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLL 170
                         170       180
                  ....*....|....*....|
gi 1130874348 449 LNAKEIQRAYRKNDLMSQES 468
Cdd:cd17325   171 LPEPRPPPNKRAVSAARLRS 190
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
60-201 9.71e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 38.17  E-value: 9.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130874348  60 LQGVVSSSLVLGAFFGALGCGRIADKFGRKQTLRWIAALFTSSTILCALSMNFLFMSFFRFALGLSVGAASSLSPMYLAE 139
Cdd:cd17446    34 LRQLAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSLNVE 113
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1130874348 140 ISPEPVRTINVNKNAIFIVLGQL----SAFCMnaflgniwgnwnPIWRIMIVSASIPAIILWINSF 201
Cdd:cd17446   114 WMPTRVRAVVGTLLGYCYTLGQLilagVAYAI------------RDWRWLQLAVSLPFFIFFLYSW 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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