NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1130413438|ref|NP_001335062|]
View 

cyclin-I isoform a [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 44-142 4.26e-64

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


:

Pssm-ID: 410230  Cd Length: 99  Bit Score: 199.46  E-value: 4.26e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCS 123
Cdd:cd20526     1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                          90
                  ....*....|....*....
gi 1130413438 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526    81 VAEVLRMERIILDKLHWDL 99
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 146-218 8.44e-03

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20529:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 101  Bit Score: 35.42  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438 146 TPLDFLHIFHAIAVSTrpqllFSLPKLSPSQHLAVLTKQLLH--------CMACNQLLQFRGSMLALAMV--SLEMEKLI 215
Cdd:cd20529     2 TPAHFLEYYLSQGVLF-----VDDHDGLPSELLEKVKEYVRKyadffldlSLQDYAFLNYKPSLLAAACIaaARKALGLS 76


                  ...
gi 1130413438 216 PDW 218
Cdd:cd20529    77 PTW 79
 
Name Accession Description Interval E-value
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 44-142 4.26e-64

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 199.46  E-value: 4.26e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCS 123
Cdd:cd20526     1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                          90
                  ....*....|....*....
gi 1130413438 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526    81 VAEVLRMERIILDKLHWDL 99
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-142 5.44e-21

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 87.57  E-value: 5.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  26 MWKVNVRKMPSNQ------NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAA 99
Cdd:pfam00134   6 LRELELKYLPKPDymdqqpDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1130413438 100 KtVEEDErIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDL 142
Cdd:pfam00134  86 K-YEEIY-PPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 50-136 6.60e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.16  E-value: 6.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438   50 QWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDsfcgCSSSEILR 129
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILR 76


                   ....*..
gi 1130413438  130 MERIILD 136
Cdd:smart00385  77 MERLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
13-214 8.73e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 75.20  E-value: 8.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  13 SFLLEKAITREAQMwKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAI 92
Cdd:COG5024   182 SDIFEYLLKLELID-LPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGI 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  93 SCFFLAAKtVEEDERiPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIA---VSTRPQLLFSL 169
Cdd:COG5024   261 SALFIASK-YEEVNC-PSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASdydIFSRTPAKFSS 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1130413438 170 PkLSPSqhlavltkqllhcmaCNQLLQFRGSMLALAMVSLEMEKL 214
Cdd:COG5024   339 E-ISPV---------------DYKFIQISPSWCAAAAMYLSRKIL 367
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 146-218 8.44e-03

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 35.42  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438 146 TPLDFLHIFHAIAVSTrpqllFSLPKLSPSQHLAVLTKQLLH--------CMACNQLLQFRGSMLALAMV--SLEMEKLI 215
Cdd:cd20529     2 TPAHFLEYYLSQGVLF-----VDDHDGLPSELLEKVKEYVRKyadffldlSLQDYAFLNYKPSLLAAACIaaARKALGLS 76


                  ...
gi 1130413438 216 PDW 218
Cdd:cd20529    77 PTW 79
 
Name Accession Description Interval E-value
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 44-142 4.26e-64

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 199.46  E-value: 4.26e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCS 123
Cdd:cd20526     1 QRDEAVRWLAELNSQFKFYPETFALAVSILDRFLASVKARPKYLRCIAISCLFLAAKTNEEDEVIPSTKDLVRVSKCGCS 80

                          90
                  ....*....|....*....
gi 1130413438 124 SSEILRMERIILDKLNWDL 142
Cdd:cd20526    81 VAEVLRMERIILDKLHWDL 99
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 45-138 9.38e-32

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 115.14  E-value: 9.38e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSS 124
Cdd:cd20523     1 RDAAVDRLRCLHRFYGFSPETFALAVNLLDRFLSKVKVKPKHLACITVSCFHIAIKSVEEDQNIPSAEDLIRISQCGCTA 80

                          90
                  ....*....|....
gi 1130413438 125 SEILRMERIILDKL 138
Cdd:cd20523    81 ADLMRMEGIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 45-139 5.52e-23

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 91.83  E-value: 5.52e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSS 124
Cdd:cd20584     2 RDAKVEDLWSLTNFFGFSTETFVLAVNILDRFLALMKVKPKHLSCIGICCFHLAARVVEEECNIPSSHDLIRISQCKCTV 81

                          90
                  ....*....|....*
gi 1130413438 125 SEILRMERIILDKLN 139
Cdd:cd20584    82 SDLKRMEKIISEKLH 96
CYCLIN_CCNG1 cd20583
cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has ...
 45-140 1.57e-22

cyclin box found in cyclin-G1 (CCNG1) and similar proteins; CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG1 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410286  Cd Length: 98  Bit Score: 90.65  E-value: 1.57e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCSS 124
Cdd:cd20583     2 RDFEVKDLLSLTQFFGFSTETFSLAVNLLDRFLAKMKVQPKHLGCVGLSCFYLAVKAIEEERNVPLATDLIRISQYRFTV 81

                          90
                  ....*....|....*.
gi 1130413438 125 SEILRMERIILDKLNW 140
Cdd:cd20583    82 SDMMRMEKIILEKLCW 97
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 26-142 5.44e-21

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 87.57  E-value: 5.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  26 MWKVNVRKMPSNQ------NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAA 99
Cdd:pfam00134   6 LRELELKYLPKPDymdqqpDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRFLSKKSVPKNKLQLVGVTCLFIAA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1130413438 100 KtVEEDErIPVLKVLARDSFCGCSSSEILRMERIILDKLNWDL 142
Cdd:pfam00134  86 K-YEEIY-PPTVEDLVYITDNAYTREEILRMERLILETLNFDL 126
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 21-139 1.09e-16

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 75.64  E-value: 1.09e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  21 TREAQMwKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAK 100
Cdd:cd20507    14 QLEKKY-AIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRYLSKKQVPRKKLQLVGVTALLIASK 92

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1130413438 101 TveEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLN 139
Cdd:cd20507    93 Y--EEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 50-136 6.60e-15

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 69.16  E-value: 6.60e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438   50 QWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDsfcgCSSSEILR 129
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRFLSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY----FTEEEILR 76


                   ....*..
gi 1130413438  130 MERIILD 136
Cdd:smart00385  77 MERLLLE 83
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
13-214 8.73e-15

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 75.20  E-value: 8.73e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  13 SFLLEKAITREAQMwKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAI 92
Cdd:COG5024   182 SDIFEYLLKLELID-LPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRFLSSRVVSLEKYQLVGI 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  93 SCFFLAAKtVEEDERiPVLKVLARDSFCGCSSSEILRMERIILDKLNWDLHTATPLDFLHIFHAIA---VSTRPQLLFSL 169
Cdd:COG5024   261 SALFIASK-YEEVNC-PSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKASdydIFSRTPAKFSS 338

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1130413438 170 PkLSPSqhlavltkqllhcmaCNQLLQFRGSMLALAMVSLEMEKL 214
Cdd:COG5024   339 E-ISPV---------------DYKFIQISPSWCAAAAMYLSRKIL 367
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 18-140 1.82e-14

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 69.91  E-value: 1.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  18 KAITREAQMWKVNVRKMPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPK-YLSCIAISCFF 96
Cdd:cd20579    16 KNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQENVVKtRLQLIGISSLF 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1130413438  97 LAAKTveEDERIPVLKVLARDSFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20579    96 IAAKL--EEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 47-141 4.22e-14

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 67.41  E-value: 4.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  47 EVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARdsFCGCSSSE 126
Cdd:cd20559     1 ALLDFLFELHVELRLSPQTFFLSVNLIDRYCSKRIVLKKHYQLVGCTCLWIASKFWESKARVPLLSELSK--MCCNSYGE 78

                          90
                  ....*....|....*..
gi 1130413438 127 --ILRMERIILDKLNWD 141
Cdd:cd20559    79 elFIQMEMHILNTLNWD 95
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 39-140 2.29e-13

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 66.57  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  39 NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKY-LSCIAISCFFLAAKTveEDERIPVLKVLARD 117
Cdd:cd20519    31 SLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTqLQLIGITCLFIAAKL--EEIYPPKLSEFAYV 108

                          90       100
                  ....*....|....*....|...
gi 1130413438 118 SFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20519   109 TDGACTEDEILTMELIILKALNW 131
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 34-140 1.14e-12

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 64.62  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  34 MPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveEDERIPVLKV 113
Cdd:cd20568    30 MDDQKELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRFLSKRVVSLNKLQLVGISALFIASKY--EEVNSPSIKN 107

                          90       100
                  ....*....|....*....|....*..
gi 1130413438 114 LARDSFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20568   108 FAYMTDGAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 44-140 2.57e-12

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 62.62  E-value: 2.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  44 QRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARDSFCGCS 123
Cdd:cd20528     6 LRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMDRYDISEDQLHLVALTCLLLAAKFEELDDNIPKISDLNRYLCNSVY 85

                          90
                  ....*....|....*...
gi 1130413438 124 S-SEILRMERIILDKLNW 140
Cdd:cd20528    86 SkQEYLQMELLILEFFQW 103
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 47-133 2.80e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 62.04  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  47 EVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKtveEDERIPVLKVLARdsFCGCSSSE 126
Cdd:cd00043     1 KAVDFIRRLCSKLGLPEEVLELAIELLDRFLSKGLLLGRSPELIAAACLYLACK---LEELPRTLKEIAK--VSGVSEKE 75


                  ....*..
gi 1130413438 127 ILRMERI 133
Cdd:cd00043    76 LRKAEKE 82
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 45-138 6.44e-12

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 61.19  E-value: 6.44e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEedERIPVLKVLARDSFCGCSS 124
Cdd:cd20536     2 RAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTPVARDCFQLLGVTSLLIACKQEE--IYPPEVKDLLALCCGAYTR 79

                          90
                  ....*....|....
gi 1130413438 125 SEILRMERIILDKL 138
Cdd:cd20536    80 EQICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 45-142 6.84e-12

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 61.18  E-value: 6.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVeedERIP----VLKVLARDSFc 120
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQKISLSLLQLLGITCLFIACKFE---ERFPpevaTLCYLTDDSY- 76

                          90       100
                  ....*....|....*....|..
gi 1130413438 121 gcSSSEILRMERIILDKLNWDL 142
Cdd:cd20542    77 --SKKQVLRMERRVLRRLRFDL 96
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 34-140 5.95e-11

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 60.05  E-value: 5.95e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  34 MPSNQ-NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveEDERIPVLK 112
Cdd:cd20567    42 YMSQQpDINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRFLSVKQVPRKELQLVGVTAMLIASKY--EEIWAPEVN 119

                          90       100
                  ....*....|....*....|....*...
gi 1130413438 113 VLARDSFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20567   120 DFVYISDNAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 42-140 1.42e-10

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 58.70  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  42 PSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVK-AHPKYLSCIAISCFFLAAKTveEDERIPVLKVLARDSFC 120
Cdd:cd20580    40 PKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKnINKSMLQLIGITSLFIASKL--EEIYPPKLHEFAYVTDG 117

                          90       100
                  ....*....|....*....|
gi 1130413438 121 GCSSSEILRMERIILDKLNW 140
Cdd:cd20580   118 ACSEDDILDMELIILKALKW 137
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 34-141 4.71e-10

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 57.26  E-value: 4.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  34 MPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveeDERIPVLKv 113
Cdd:cd20508    37 LEKQTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLYLSKKVVKKEKLQLLGATAILIASKF---DERCPPCV- 112

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1130413438 114 larDSF---CGC--SSSEILRMERIILDKLNWD 141
Cdd:cd20508   113 ---DDFlyiCDDayTREELLKMEREILKTLDFD 142
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 39-141 2.35e-09

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 55.38  E-value: 2.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  39 NVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveeDERIPvlkvLARDS 118
Cdd:cd20515    50 EIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRFLSLVPIRKSQLQLLGAVCLFLASKL---KETIP----LTAEK 122

                          90       100
                  ....*....|....*....|....*...
gi 1130413438 119 FC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20515   123 LCiytdnSITLQELLDWELLVLTKLKWD 150
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 45-140 2.54e-09

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 53.86  E-value: 2.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAH---PKYLSCIAISCFFLAAKtVEEDERIPVLKVLARDSFCG 121
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRFLSSYDLPkdkPWMLQLLAVACLSLAAK-MEETDVPLLVDLQVEEPKYV 80

                          90
                  ....*....|....*....
gi 1130413438 122 CSSSEILRMERIILDKLNW 140
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 38-141 2.32e-08

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 52.41  E-value: 2.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveedERIPVLKVlarD 117
Cdd:cd20562    35 RDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRFLSGNYVNRQRLQLLGVSCMLIASKY----EEICAPQV---E 107

                          90       100
                  ....*....|....*....|....*....
gi 1130413438 118 SFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20562   108 EFCyitdnTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 34-139 7.73e-08

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 50.71  E-value: 7.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  34 MPSNQNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKtVEEDERIPVlkv 113
Cdd:cd20504    24 MRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRFLSQMSVLRSKLQLVGTACMFIAAK-YEEIYPPEV--- 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1130413438 114 larDSFC-----GCSSSEILRMERIILDKLN 139
Cdd:cd20504   100 ---EEFVyitddTYTKKQVLRMEHLVLKVLS 127
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 38-141 1.35e-07

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 50.38  E-value: 1.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveeDERIPvlkvLARD 117
Cdd:cd20574    49 KDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRFLAVVPTRKCHLQLLGAVCMFLASKL---KETIP----LTAE 121

                          90       100
                  ....*....|....*....|....*....
gi 1130413438 118 SFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20574   122 KLCiytdnSIKPQELLEWELVVLGKLKWN 150
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 38-141 1.54e-07

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 50.36  E-value: 1.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveeDERIPvlkvLARD 117
Cdd:cd20573    48 KEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSVEPTKKSRLQLLGATCMFLASKM---KETIP----LTAE 120

                          90       100
                  ....*....|....*....|....*....
gi 1130413438 118 SFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20573   121 KLCiytdnSIRPEELLQMELLVLNKLKWD 149
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 38-140 1.49e-06

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 47.18  E-value: 1.49e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveEDERIPVLKVLARD 117
Cdd:cd20565    29 QEVTGNMRAILIDWLVQVQMKFRLLQETMYMTVAIIDRFLQNNPVPKKMLQLVGVTAMFIASKY--EEMYPPEIGDFAFV 106

                          90       100
                  ....*....|....*....|...
gi 1130413438 118 SFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20565   107 TDNTYTKHQIRQMEMKILRALDF 129
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 31-141 1.56e-06

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 46.97  E-value: 1.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  31 VRKMPsnqNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVE-EDERIP 109
Cdd:cd20561    26 MKKQP---DITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRFLSSMSVLRGKLQLVGTAAMLLASKFEEiYPPEVA 102

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1130413438 110 VLKVLARDSFcgcSSSEILRMERIILDKLNWD 141
Cdd:cd20561   103 EFVYITDDTY---TKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 38-141 1.53e-05

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 44.60  E-value: 1.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveeDERIPvlkvLARD 117
Cdd:cd20575    49 REIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRYLSCVPTRKAQLQLLGAVCMLLASKL---RETTP----LTIE 121

                          90       100
                  ....*....|....*....|....*....
gi 1130413438 118 SFC-----GCSSSEILRMERIILDKLNWD 141
Cdd:cd20575   122 KLCiytdnSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 58-142 4.38e-05

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 43.35  E-value: 4.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  58 QFNLYPETFALASSLLDRFlatvkahpkYLSC---------IAISCFFLAAKTveEDERIPVlkvlarDSFCG------C 122
Cdd:cd20524    68 AFKLPDSVLATALTYFKRF---------YLKNsvmeyhpkeIMLTCLYLACKV--EEFNISI------DQFVGnikeseK 130

                          90       100
                  ....*....|....*....|
gi 1130413438 123 SSSEILRMERIILDKLNWDL 142
Cdd:cd20524   131 TAEIILEYELLLLQGLNFHL 150
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 45-140 9.83e-05

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 41.01  E-value: 9.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  45 RDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKtVEEDERIPV--LKVLARDSFcgc 122
Cdd:cd20517     6 RKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLKKQGTKETLQKTGAACLLIASK-IRTVKPITVskLTYLSCDCF--- 81

                          90
                  ....*....|....*...
gi 1130413438 123 SSSEILRMERIILDKLNW 140
Cdd:cd20517    82 TNLELINQEKDILEALKW 99
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 38-140 1.76e-04

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 41.00  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  38 QNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTveEDERIPVLKVLARD 117
Cdd:cd20566    33 KEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQPVSRKKLQLVGVTALLLASKY--EEMYSPEIGDFVYI 110

                          90       100
                  ....*....|....*....|...
gi 1130413438 118 SFCGCSSSEILRMERIILDKLNW 140
Cdd:cd20566   111 TDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 31-141 5.50e-04

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 40.21  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  31 VRKMPsnqNVSPSQRDEVIQWLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVE-----ED 105
Cdd:cd20560    58 MRKQP---DITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRFLSCMSVLRGKLQLVGTAAILLASKYEEiyppeVD 134

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1130413438 106 ERIPVlkvlARDSFcgcSSSEILRMERIILDKLNWD 141
Cdd:cd20560   135 EFVYI----TDDTY---TKKQLLRMEHLLLKVLAFD 163
CYCLIN_ScPCL1-like cd20557
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar ...
 50-140 1.35e-03

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins; The family includes a group of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase, such as Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2, PCL9 and their vertebrate counterparts, cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1). PCL1 (also called PHO85 cyclin-1, or cyclin HCS26) and PCL2 (also called PHO85 cyclin-1, or cyclin HCS26 homolog) are G1/S-specific cyclin partners of the cyclin-dependent kinase (CDK) PHO85. They are essential for the control of the cell cycle at the G1/S (start) transition. The PCL1-PHO85 cyclin-CDK holoenzyme is involved in phosphorylation of the CDK inhibitor (CKI) SIC1, which is required for its ubiquitination and degradation, releasing repression of b-type cyclins and promoting exit from mitosis. Together with cyclin PCL2, it positively controls degradation of sphingoid long chain base kinase LCB4. PCL1-PHO85 also phosphorylates HMS1, NCP1 and NPA3, which may all have a role in mitotic exit. PCL2-PHO85 also phosphorylates RVS167, linking cyclin-CDK activity with organization of the actin cytoskeleton. PCL9 is an M/G1-specific cyclin partner of the cyclin-dependent kinase (CDK) PHO85. It may have a role in bud site selection in the G1 phase. The family also includes cyclin Pas1/PHO80 domain-containing protein 1 (CNPPD1) and similar proteins. Their biological functions remain unclear. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410260  Cd Length: 94  Bit Score: 37.64  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  50 QWLAKLKYQFNLYPETFALASSLLDRFLAT----VKAHPKYLSCIAISCFFLAAKTVEeDERIPvLKVLARdsFCGCSSS 125
Cdd:cd20557     4 SFIARLLRRTRLSPSVVLLALVYLERLRRRlpeaLLGQEGSPYRLFLVALMLASKYLD-DESYS-NKSWAE--ISGLPVR 79

                          90
                  ....*....|....*
gi 1130413438 126 EILRMERIILDKLNW 140
Cdd:cd20557    80 ELNAMEREFLEALDW 94
CCL1 COG5333
Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision ...
 51-154 1.42e-03

Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair];


Pssm-ID: 227640 [Multi-domain]  Cd Length: 297  Bit Score: 40.10  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  51 WLAKLKYQFNLYPETFALASSLLDRFLATVKAHPKYLSCIAISCFFLAAKTVEEDERIPVLKVLARD---SFCGCSSSEI 127
Cdd:COG5333    51 LIMDLCTRLNLPQTVLATAILFFSRFYLKNSVEEISLYSVVTTCVYLACKVEDTPRDISIESFEARDlwsEEPKSSRERI 130

                          90       100
                  ....*....|....*....|....*..
gi 1130413438 128 LRMERIILDKLNWDLHTATPLDFLHIF 154
Cdd:COG5333   131 LEYEFELLEALDFDLHVHHPYKYLEGF 157
CYCLIN_CCNK_rpt1 cd20530
first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase ...
 60-141 2.86e-03

first cyclin box found in cyclin-K (CCNK) and similar proteins; CCNK is a novel RNA polymerase II-associated C-type cyclin possessing both carboxy-terminal domain kinase and Cdk-activating kinase activity. It is a regulatory subunit of cyclin-dependent kinases that mediates the activation of these target kinases. It plays a role in transcriptional regulation by controlling the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A). CCNK contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410233 [Multi-domain]  Cd Length: 115  Bit Score: 37.21  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438  60 NLYPETFALASSLLDRFLA--TVKAHPKYLscIAISCFFLAAKtVEEDER-----IPVLKVLARD----SFCGCSSSEIL 128
Cdd:cd20530    26 GLPYDTIATGIVYFHRFYMfhSFKDFDRYV--TAACCLFLAGK-VEETPKkckdiIKTARSLLNDkqfaQFGDDPKEEVM 102

                          90
                  ....*....|...
gi 1130413438 129 RMERIILDKLNWD 141
Cdd:cd20530   103 VLERILLQTIKFD 115
CYCLIN_CCNJ-like_rpt2 cd20529
second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 146-218 8.44e-03

second cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410232 [Multi-domain]  Cd Length: 101  Bit Score: 35.42  E-value: 8.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1130413438 146 TPLDFLHIFHAIAVSTrpqllFSLPKLSPSQHLAVLTKQLLH--------CMACNQLLQFRGSMLALAMV--SLEMEKLI 215
Cdd:cd20529     2 TPAHFLEYYLSQGVLF-----VDDHDGLPSELLEKVKEYVRKyadffldlSLQDYAFLNYKPSLLAAACIaaARKALGLS 76


                  ...
gi 1130413438 216 PDW 218
Cdd:cd20529    77 PTW 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH