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doublesex- and mab-3-related transcription factor A2 [Mus musculus]
doublesex- and mab-3-related transcription factor A2( domain architecture ID 10465234)
doublesex- and mab-3-related transcription factor A2 (DMRTA2) may be involved in sexual development
List of domain hits
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Name | Accession | Description | Interval | E-value | |||
DMRT5_DMB | pfam20624 | DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ... |
423-502 | 2.51e-34 | |||
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation. : Pssm-ID: 466773 Cd Length: 88 Bit Score: 124.29 E-value: 2.51e-34
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DM | pfam00751 | DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ... |
65-111 | 1.16e-30 | |||
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA. : Pssm-ID: 459924 Cd Length: 47 Bit Score: 113.14 E-value: 1.16e-30
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CUE_DMA_DMRTA2 | cd14418 | CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); ... |
308-349 | 3.84e-24 | |||
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis. : Pssm-ID: 270601 Cd Length: 42 Bit Score: 94.99 E-value: 3.84e-24
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Name | Accession | Description | Interval | E-value | |||
DMRT5_DMB | pfam20624 | DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ... |
423-502 | 2.51e-34 | |||
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation. Pssm-ID: 466773 Cd Length: 88 Bit Score: 124.29 E-value: 2.51e-34
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DM | pfam00751 | DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ... |
65-111 | 1.16e-30 | |||
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA. Pssm-ID: 459924 Cd Length: 47 Bit Score: 113.14 E-value: 1.16e-30
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DM | smart00301 | Doublesex DNA-binding motif; |
65-118 | 6.14e-26 | |||
Doublesex DNA-binding motif; Pssm-ID: 214606 Cd Length: 54 Bit Score: 100.13 E-value: 6.14e-26
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CUE_DMA_DMRTA2 | cd14418 | CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); ... |
308-349 | 3.84e-24 | |||
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis. Pssm-ID: 270601 Cd Length: 42 Bit Score: 94.99 E-value: 3.84e-24
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DMA | pfam03474 | DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with ... |
310-345 | 3.73e-18 | |||
DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown. Pssm-ID: 460937 Cd Length: 36 Bit Score: 77.60 E-value: 3.73e-18
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Name | Accession | Description | Interval | E-value | |||
DMRT5_DMB | pfam20624 | DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex ... |
423-502 | 2.51e-34 | |||
DMRT5, DMB domain; This is the DMB domain found at the C-terminal of DMRT5 proteins (doublesex and mab-3 related transcription factor, also known as Doublesex- and mab-3-related transcription factor A2). These proteins are involved in sexual development although not restricted to the developing gonads in vertebrates. DMRT5, together with DMRT4, has been identified as an important regulator of neurogenesis. This domain is adjacent the DMA domain (pfam03474), both of which are required for neuronal differentiation. Pssm-ID: 466773 Cd Length: 88 Bit Score: 124.29 E-value: 2.51e-34
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DM | pfam00751 | DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single ... |
65-111 | 1.16e-30 | |||
DM DNA binding domain; The DM domain is named after dsx and mab-3. dsx contains a single amino-terminal DM domain, whereas mab-3 contains two amino-terminal domains. The DM domain has a pattern of conserved zinc chelating residues C2H2C4. The dsx DM domain has been shown to dimerize and bind palindromic DNA. Pssm-ID: 459924 Cd Length: 47 Bit Score: 113.14 E-value: 1.16e-30
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DM | smart00301 | Doublesex DNA-binding motif; |
65-118 | 6.14e-26 | |||
Doublesex DNA-binding motif; Pssm-ID: 214606 Cd Length: 54 Bit Score: 100.13 E-value: 6.14e-26
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CUE_DMA_DMRTA2 | cd14418 | CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); ... |
308-349 | 3.84e-24 | |||
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A2 (DMRTA2); DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis. Pssm-ID: 270601 Cd Length: 42 Bit Score: 94.99 E-value: 3.84e-24
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CUE_DMA | cd14370 | CUE-like DMA domain found in the DM domain gene family encodes putative transcription factors ... |
308-347 | 1.87e-19 | |||
CUE-like DMA domain found in the DM domain gene family encodes putative transcription factors DMRTA1, DMRTA2 and DMRTA3; The DM domain proteins are related to the sexual regulators doublesex from Drosophila melanogaster and MAB-3 from Caenorhabditis elegans. Thus, they have been named as doublesex- and mab-3-related transcription factors and may be involved in sexual development or in somite development. All DM domain proteins contain a DM domain which is an unusual zinc finger motif. In addition to an N-terminal DM domain, members in this family, including DMRTA1, DMRTA2 and DMRTA3, also harbor additional CUE-like DMA domain. DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the D. melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice. DMRTA2, also called Doublesex- and mab-3-related transcription factor 5 (DMRT5), is encoded by gene DMRT2. In the zebrafish, DMRT2 is involved in somite development. DMRTA2 may act as an activator of cyclin-dependent kinase inhibitor 2C (cdkn2c) during spermatogenesis. It may also play significant roles in embryonic neurogenesis. DMRTA3 is encoded by tumor suppressor gene DMRT3 which serves as a novel potential target for homozygous deletion in squamous cell carcinoma of the lung. Pssm-ID: 270553 Cd Length: 40 Bit Score: 81.45 E-value: 1.87e-19
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DMA | pfam03474 | DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with ... |
310-345 | 3.73e-18 | |||
DMRTA motif; This region is found to the C-terminus of the pfam00751. DM-domain proteins with this motif are known as DMRTA proteins. The function of this region is unknown. Pssm-ID: 460937 Cd Length: 36 Bit Score: 77.60 E-value: 3.73e-18
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CUE_DMA_DMRTA1 | cd14417 | CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and ... |
308-347 | 4.10e-15 | |||
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor A1 (DMRTA1) and similar proteins; DMRTA1 is encoded by gene DMRT1, a vertebrate equivalent of the Drosophila melanogaster master sex regulator gene, doublesex. In D. melanogaster, doublesex controls the terminal switch of the pathway leading to sex fate choice. DMRT1 may function as regulator of sex differentiation in vertebrate. Especially, it is required for testis differentiation, but is not involved in the gonadal sex fate choice. Pssm-ID: 270600 Cd Length: 40 Bit Score: 69.23 E-value: 4.10e-15
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CUE_DMA_DMRTA3 | cd14419 | CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3); ... |
310-348 | 2.94e-09 | |||
CUE-like DMA domain found in doublesex- and mab-3-related transcription factor 3 (DMRTA3); DMRTA3 is encoded by tumor suppressor gene DMRT3 which serves as a novel potential target for homozygous deletion in squamous cell carcinoma of the lung. Pssm-ID: 270602 Cd Length: 43 Bit Score: 52.51 E-value: 2.94e-09
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CUE | cd14279 | CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ... |
312-347 | 7.22e-05 | |||
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains. Pssm-ID: 270465 Cd Length: 38 Bit Score: 40.14 E-value: 7.22e-05
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