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Conserved domains on  [gi|112790163|ref|NP_005946|]
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metal regulatory transcription factor 1 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.02e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 112790163 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 5.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 112790163 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.02e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 112790163 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 8.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.23e-06
                          10        20
                  ....*....|....*....|....*..
gi 112790163  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 5.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 112790163 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.02e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.64  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 112790163 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-316 5.60e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 5.60e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 172 CNQEGCGKAFLTSYSLRIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCE-SEGCSKYFTTLSDL 246
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkLLNSSSKFSPLLNN 369

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 112790163 247 RKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNK 316
Cdd:COG5048  370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 8.23e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 42.74  E-value: 8.23e-06
                          10        20
                  ....*....|....*....|....*..
gi 112790163  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-302 8.57e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 8.57e-05
                          10        20
                  ....*....|....*....|....*...
gi 112790163  275 HLKTHVRTHTGERPFFCPSngCEKTFST 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 231-310 8.67e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.02  E-value: 8.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163  231 CESEGCSKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNgCEKTFSTQY 304
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN-CLLRFRTHR 80


                  ....*.
gi 112790163  305 SLKSHM 310
Cdd:pfam15909  81 SLFKHL 86
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-284 1.67e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 197 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfnceseGCSKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 276
Cdd:COG5189  347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                 ....*...
gi 112790163 277 KTHvRTHT 284
Cdd:COG5189  415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-213 2.22e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.22e-04
                          10        20
                  ....*....|....*....|....*...
gi 112790163  186 SLRIHVRVHTKEKPFECDVqgCEKAFNT 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 5.00e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 5.00e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 112790163 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 172-250 2.14e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.17  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163  172 CNQEGCGKAFLTSYSLRIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSD 245
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRS 81


                  ....*
gi 112790163  246 LRKHI 250
Cdd:pfam15909  82 LFKHL 86
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-334 4.64e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112790163 225 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 304
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                         90       100       110
                 ....*....|....*....|....*....|
gi 112790163 305 SLKSHMKGHDNKGHSYNALPQHNGSEDTNH 334
Cdd:COG5048  104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 259-283 6.59e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.59e-03
                          10        20
                  ....*....|....*....|....*
gi 112790163  259 FRCDHdgCGKAFAASHHLKTHVRTH 283
Cdd:pfam00096   1 YKCPD--CGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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