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Conserved domains on  [gi|1127774881|ref|NP_001334988|]
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C-X-C chemokine receptor type 4 isoform d [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 12114338)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
72-346 0e+00

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


:

Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 527.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15179     1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPND---LW 228
Cdd:cd15179    81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDtfeLW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCE 308
Cdd:cd15179   161 VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15179   241 MEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
CXCR4_N pfam12109
CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. ...
39-71 9.12e-14

CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.


:

Pssm-ID: 432337  Cd Length: 33  Bit Score: 64.80  E-value: 9.12e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1127774881  39 IYTSDNYTEEMGSGDYDSMKEPCFREENANFNK 71
Cdd:pfam12109   1 IEFSDNNTEEIGSGDYGDYKEPCFQHENADFNR 33
 
Name Accession Description Interval E-value
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
72-346 0e+00

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 527.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15179     1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPND---LW 228
Cdd:cd15179    81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDtfeLW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCE 308
Cdd:cd15179   161 VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15179   241 MEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
88-335 9.80e-74

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 229.88  E-value: 9.80e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  88 GNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA--NWYFGNFLCKAVHVIYTVNLYSSVLILAFIS 164
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 165 LDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY--ICDRFYPNDLWV-VVFQFQHIMVGL 241
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNvtVCFIDFPEDLSKpVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 242 ILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIKQGCEFENTV 313
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLrksaskqkSSERTQRRRKALKTLAVVVVVFILCWLPYHI------VNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|..
gi 1127774881 314 HKWISITEALAFFHCCLNPILY 335
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-365 1.43e-51

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 175.35  E-value: 1.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  45 YTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKkLRSMTDKYRLHLSVADLLFVITL 124
Cdd:PHA03087   14 TTDYYYDTYYDEDYADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 125 PFWAVDAVA-NWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP 203
Cdd:PHA03087   93 PFQIYYYILfQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 204 DFIFANVSEADDRYICDRFYPND--LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS-KGHQKRKALKTTVILILA 280
Cdd:PHA03087  173 ILFVYTTKKDHETLICCMFYNNKtmNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGInKSKKNKKAIKLVLIIVIL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 281 FFACWLPYYIGISIDSFILLEiIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGaKFKTSAQHALTSVSRGSSLK 360
Cdd:PHA03087  253 FVIFWLPFNVSVFVYSLHILH-FKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVS-EFFNKHKKKSLKLMFTSSGK 330

                  ....*
gi 1127774881 361 ILSKG 365
Cdd:PHA03087  331 SISIG 335
CXCR4_N pfam12109
CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. ...
39-71 9.12e-14

CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.


Pssm-ID: 432337  Cd Length: 33  Bit Score: 64.80  E-value: 9.12e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1127774881  39 IYTSDNYTEEMGSGDYDSMKEPCFREENANFNK 71
Cdd:pfam12109   1 IEFSDNNTEEIGSGDYGDYKEPCFQHENADFNR 33
 
Name Accession Description Interval E-value
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
72-346 0e+00

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 527.41  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15179     1 IFLPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAANWYFGNFLCKAVHVIYTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPND---LW 228
Cdd:cd15179    81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKVSELDDRYICDRIYPEDtfeLW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCE 308
Cdd:cd15179   161 VVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQSCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15179   241 MEQTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 278
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
72-345 7.68e-136

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 388.88  E-value: 7.68e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd14984     1 VFLPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADGWVFGSFLCKLVSALYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL---W 228
Cdd:cd14984    81 NFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEENGSSICSYDYPEDTattW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCE 308
Cdd:cd14984   161 KTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRSCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14984   241 LSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKY 277
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
72-345 3.18e-91

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 275.69  E-value: 3.18e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15178     1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIFGTFMCKLVSLLQEA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIF--ANVSEADDRYICDRFYPN---D 226
Cdd:cd15178    81 NFYSGILLLACISVDRYLAIVHATRALTQKRHLV-KFVCAGVWLLSLLLSLPALLNrdAFKPPNSGRTVCYENLGNesaD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd15178   160 KWRVVLRILRHTLGFLLPLVVMLFCYGFTIKTLLQTRSFQKHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLITET 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15178   240 CELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNN 278
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
72-343 1.57e-83

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 255.77  E-value: 1.57e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15180     1 VFLPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVHGWIFGTGLCKLAGAVFKI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIF--ANVSEADDRYICDRFYPND--L 227
Cdd:cd15180    81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFleATKDPRQNKTECVHNFPQSdtY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCY-CIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd15180   161 WWLALRLLYHIVGFLLPLAVMVYCYtSILLRLLRSSQGFQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDRN 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15180   241 CGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
72-343 1.05e-76

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 238.50  E-value: 1.05e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15172     1 VFVPVIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVYEAHQWIFGNFSCKLLRGIYAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNS--QRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRFYPND- 226
Cdd:cd15172    81 NFYSGMLLLACISVDRYIAIVQATKSfrLRSRTLAYSKLICAAVWLLAILISLPTFIFSEVYDfgLEEQYVCEPKYPKNs 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ---LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEii 303
Cdd:cd15172   161 taiMWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLLIEAINLGE-- 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15172   239 QQSCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
73-343 2.16e-76

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 237.73  E-value: 2.16e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15174     2 FLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASSGWVFGTFLCKVVNSMYKIN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQ--RPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW-- 228
Cdd:cd15174    82 FYSCMLLLTCISVDRYIAIVQATKAHnsKNKRLLYSKLVCFFVWLLSTILSLPEILFSQSKEEESVTTCTMVYPSNESnr 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 --VVVFQFQhIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd15174   162 fkVAVLALK-VTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNITITD 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15174   241 CATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFR 277
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
72-343 2.93e-76

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 237.34  E-value: 2.93e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15181     1 VFIPLAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIAGWVFGTFLCKLVGAIHKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD--RYICDrFY----PN 225
Cdd:cd15181    81 NFYCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNanRTSCS-FHqygiHE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL-SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIK 304
Cdd:cd15181   160 SNWWLTSRFLYHVVGFFLPLLIMGYCYATIVVTLcQSSRRLQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVV 239
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 305 QGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15181   240 KNCKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFR 278
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
72-343 2.85e-75

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 234.64  E-value: 2.85e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15176     1 LFLPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAVNGWVLGTAMCKITSALYTM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLaeKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV-- 229
Cdd:cd15176    81 NFSCGMQFLACISVDRYVAITKATSRQFTGKHC--WIVCLCVWLLAILLSIPDLVFSTVRENSDRYRCLPVFPPSLVTsa 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 -VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCE 308
Cdd:cd15176   159 kATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLITDCS 238
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15176   239 MSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
72-343 3.13e-75

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 234.28  E-value: 3.13e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15173     1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAHEWIFGTVMCKITNGLYTI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHAT--NSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRyICDRFYPNDLWV 229
Cdd:cd15173    81 NLYSSMLILTCITVDRFIVIVQATkaHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSSK-ICSMVYPPDAIE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGisidsfILLEIIKQGCEF 309
Cdd:cd15173   160 VVVNIIQMTVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIM------KLIRTLHIENTD 233
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 310 ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15173   234 STNFKYAILITEAIAYLHACLNPILYAFVGVKFR 267
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
88-335 9.80e-74

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 229.88  E-value: 9.80e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  88 GNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA--NWYFGNFLCKAVHVIYTVNLYSSVLILAFIS 164
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNhgDWPFGSALCKIVGALFVVNGYASILLLTAIS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 165 LDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY--ICDRFYPNDLWV-VVFQFQHIMVGL 241
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNvtVCFIDFPEDLSKpVSYTLLISVLGF 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 242 ILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIKQGCEFENTV 313
Cdd:pfam00001 161 LLPLLVILVCYTLIIRTLrksaskqkSSERTQRRRKALKTLAVVVVVFILCWLPYHI------VNLLDSLALDCELSRLL 234
                         250       260
                  ....*....|....*....|..
gi 1127774881 314 HKWISITEALAFFHCCLNPILY 335
Cdd:pfam00001 235 DKALSVTLWLAYVNSCLNPIIY 256
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
73-343 6.14e-73

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 228.88  E-value: 6.14e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15175     2 FLPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAKKWVFGEEMCKAVYCLYKMS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQ--RPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV 230
Cdd:cd15175    82 FFSGMLLLMCISIDRYFAIVQAASAHrhRSRAVFISKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFTNNKQTLS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VF-QFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEF 309
Cdd:cd15175   162 VKiQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNTTDCDY 241
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 310 ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15175   242 SKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFR 275
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
72-343 7.04e-70

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 220.80  E-value: 7.04e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15177     1 VFQPCVYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQGWIFGNAMCKLIQGLYAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQ--RPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15177    81 NFYSGFLFLTCISVDRYVVIVRATSAHrlRPKTLFYSVLTSLIVWLLSILFALPQLIYSRVENRSELSSCRMIFPEVVSR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQH---IMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd15177   161 TVKGATAltqVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELS 240
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15177   241 CSQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFR 277
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
72-343 1.89e-69

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 219.66  E-value: 1.89e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVM-GYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15188     1 VFLPVFYTLVFLLGLAGNLLLFVVLlLYVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWHWVFGSFLCKFVSTLYT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD-RYICDRFY--PNDL 227
Cdd:cd15188    81 INFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNgVWVCHADYggHHTI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKqGC 307
Cdd:cd15188   161 WKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIG-NC 239
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 308 EFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15188   240 ERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFR 275
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
72-344 9.21e-67

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 212.61  E-value: 9.21e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15182     1 AFLPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASYHSSGWIFGEILCKAVTSIFYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEAD-DRYICDrfYPNDLWVV 230
Cdd:cd15182    81 GFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDeDGSLCE--YSSIKWKL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLIlPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKqgCEFE 310
Cdd:cd15182   159 GYYYQQNLFFLI-PLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTIPI--CECS 235
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 311 NTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15182   236 KQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRN 269
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
72-343 2.60e-63

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 204.20  E-value: 2.60e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15192     1 IMIPTVYSIIFVVGIFGNSLVVIVIYCYMKLKTVANIFLLNLALADLCFLITLPLWAAYTAMeyHWPFGNFLCKIASALV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD--RYICDRFYPN-- 225
Cdd:cd15192    81 SFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENtnITVCAFHYPSqn 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRK-----ALKTTVILILAFFACWLPYYIGISIDSFILL 300
Cdd:cd15192   161 STLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKprndeIFKMIMAVVLFFFFCWIPHQIFTFLDVLIQL 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 301 EIIkQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15192   241 KVI-QDCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFR 282
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
73-346 6.45e-63

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 202.99  E-value: 6.45e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd14985     2 VIPALYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANqyDWPFGAFLCKVSSYVIS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVS--EADDRYICDRFYPNDLW 228
Cdd:cd14985    82 VNMFASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLPTFLLRSLQaiENLNKTACIMLYPHEAW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSK------GHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEI 302
Cdd:cd14985   162 HFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYertgknGRKRRKSLKIIFALVVAFLVCWLPFHFFKFLDFLAQLGA 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 303 IKqGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd14985   242 IR-PCFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFRQKV 284
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
72-343 1.03e-62

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 202.34  E-value: 1.03e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15187     1 LFLPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLLDQWVFGNAMCKIVSGAYYI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYP--NDLWV 229
Cdd:cd15187    81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVASEDGRLQCIPFYPgqGNSWK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIkQGCEF 309
Cdd:cd15187   161 VFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHII-DGCQN 239
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 310 ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15187   240 SQRLTLALHLTETISFTHCCLNPVIYAFVGEKFK 273
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
73-343 2.53e-61

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 198.82  E-value: 2.53e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15184     2 LLPPLYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNAMCKLLTGLYHIG 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVF 232
Cdd:cd15184    82 FFSGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTKSQKEGSHYTCSPHFPPSQYQFWK 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHIM---VGLILPGIVILSCYCIIISKLSHSKGHQKR-KALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQgCE 308
Cdd:cd15184   162 NFQTLKmniLGLVLPLLVMIICYSGILKTLLRCRNEKKRhKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLNN-CS 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15184   241 SSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFR 275
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
76-338 9.47e-61

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 197.13  E-value: 9.47e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd00637     3 VLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVgLLVIPFSLVSLLLGrWWFGDALCKLLGFLQSVSL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQ 233
Cdd:cd00637    83 LASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKAYT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIISKLSHSKG---------------HQKRKALKTTVILILAFFACWLPYYIGISIDSFI 298
Cdd:cd00637   163 IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRrirssssnssrrrrrRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFG 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 299 LleiikqgcEFENTVHKWISITEALAFFHCCLNPILYAFL 338
Cdd:cd00637   243 P--------DPSPLPRILYFLALLLAYLNSAINPIIYAFF 274
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
77-343 9.86e-60

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 194.44  E-value: 9.86e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd14974     6 LYALIFLLGLPGNGLVIWVAGFKMK-RTVNTVWFLNLALADFLFCLFLPFLIVYIAmgHHWPFGSVLCKLNSFVISLNMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL------- 227
Cdd:cd14974    85 ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNLTCVEDYdlrrsrh 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 -WVVVFQFqhiMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIKQG 306
Cdd:cd14974   165 kALTVIRF---LCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHV------FALLELVAAA 235
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 CEFEnTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14974   236 GLPE-VVLLGLPLATGLAYFNSCLNPILYVFMGQDFR 271
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
72-345 1.34e-58

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 191.74  E-value: 1.34e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd14970     1 IVIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSyLLGYWPFGEVMCKIVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV-SEADDRYICDRFYPNDLWV 229
Cdd:cd14970    81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTlQEEGGTISCNLQWPDPPDY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 -----VVFQFqhiMVGLILPGIVILSCYCIIISKL----------SHSKGHQKRKALKTTVILILAFFACWLPYYIgisi 294
Cdd:cd14970   161 wgrvfTIYTF---VLGFAVPLLVITVCYSLIIRRLrssrnlstsgAREKRRARRKVTRLVLVVVAVFVVCWLPFHV---- 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 295 dsFILLEIIKQGCEFENTVHKWISITeALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14970   234 --FQIVRLLIDPPETLTVVGVFLFCI-ALSYANSCLNPILYAFLDENFRKS 281
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
72-343 1.58e-58

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 191.59  E-value: 1.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15186     1 IFLSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLINEWGLHNAMCKLTTAFFFI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADdryiCDRFYPNDL---W 228
Cdd:cd15186    81 GFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTKMKENE----CLGDYPEVLqeiW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQgCE 308
Cdd:cd15186   157 PVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFPS-CD 235
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15186   236 MKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
72-343 2.48e-54

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 180.92  E-value: 2.48e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHVIY 149
Cdd:cd14982     1 TLFPIVYSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYyyLNGGWWPFGDFLCRLTGLLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFAN-VSEADDRYICDRFYP-NDL 227
Cdd:cd14982    81 YINMYGSILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRStIAKENNSTTCFEFLSeWLA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS-----KGHQKRKALKTTVILILAFFACWLPYYIGISIdSFILLEI 302
Cdd:cd14982   161 SAAPIVLIALVVGFLIPLLIILVCYSLIIRALRRRskqsqKSVRKRKALRMILIVLAVFLVCFLPYHVTRIL-YLLVRLS 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14982   240 FIADCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFR 280
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
74-343 3.71e-54

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 181.11  E-value: 3.71e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVM--GYQKKLRSmTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15190    13 IPVIYMLVFVLGLSGNGLVLWTVfrSKRKRRRS-ADTFIANLALADLTFVVTLPLWAVYTALgyHWPFGSFLCKLSSYLV 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVS--EADDRYICDRFYP--- 224
Cdd:cd15190    92 FVNMYASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSdlEGTNKVICDMDYSgvv 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 ----NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH-------QKRKALKTTVILILAFFACWLPYYIGIS 293
Cdd:cd15190   172 snesEWAWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVARHFSKlrrkedkKKRRLLKIIITLVVTFALCWLPFHLVKT 251
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 294 IDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15190   252 LYALMYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
74-343 2.84e-53

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 178.03  E-value: 2.84e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYTV 151
Cdd:cd14987     3 LSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVqhNQWPMGEFTCKITHLIFSI 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPD--FIFANVSEADDRYICDRFYPNDL-- 227
Cdd:cd14987    83 NLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDtyFLKTVTSPSNNETYCRSFYPEESfk 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 -WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd14987   163 eWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIPFS 242
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14987   243 CQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYR 279
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
73-343 6.13e-53

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 177.25  E-value: 6.13e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15191     2 AIPVLYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATyySYGYNWLFGSVMCKICGSLLT 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVgVWIPALLLTIPDFIFANVSEADDRYI--CDRFYPNDL- 227
Cdd:cd15191    82 LNLFASIFFITCMSVDRYLAVVYPLRSQRRRSWQARLVCLL-VWVLACLSSLPTFYFRDTYYIEELGVnaCIMAFPNEKy 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 --WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH----QKR-KALKTTVILILAFFACWLPYYIGISIDSFILL 300
Cdd:cd15191   161 aqWSAGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFgknkQRRdKVLKMVAAVVLAFLICWFPFHVLTFLDALARM 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 301 EIIKQgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15191   241 GVINN-CWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFR 282
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
74-343 3.06e-52

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 175.44  E-value: 3.06e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWaVDAV--ANWYFGNFLCKAVHVIYTV 151
Cdd:cd15183     3 LPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFW-IDYKlkDDWIFGDAMCKFLSGFYYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVV 231
Cdd:cd15183    82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHTCSAHFPRKSLIRW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHI---MVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQgCE 308
Cdd:cd15183   162 KRFQALklnLLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTPS-CE 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15183   241 QSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
72-342 4.11e-52

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 175.20  E-value: 4.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15168     1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANgdHWIFGDFMCKLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15168    81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFATTGRKNNRTTCYDTTSPEELN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGL--ILPGIVILSCYCIIISKLSHSKGHQ-----KRKALKTTVILILAFFACWLPYYIGISIDSFILLEI 302
Cdd:cd15168   161 DYVIYSMVLTGLgfLLPLLIILACYGLIVRALIRKLGEGvtsalRRKSIRLVIIVLALFAVCFLPFHVTRTINLAARLLS 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15168   241 GTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKF 280
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
73-343 1.43e-51

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 173.48  E-value: 1.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd15185     2 FLPPLYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFWIHYVRWNnWVFGHGMCKLLSGFYYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL---W 228
Cdd:cd15185    82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYETQELFEEFLCSPLYPEDTedsW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLeIIKQGCE 308
Cdd:cd15185   162 KRFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSI-FFETDCE 240
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15185   241 RSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFR 275
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
45-365 1.43e-51

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 175.35  E-value: 1.43e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  45 YTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKkLRSMTDKYRLHLSVADLLFVITL 124
Cdd:PHA03087   14 TTDYYYDTYYDEDYADCDLNIGYDTNSTILIVVYSTIFFFGLVGNIIVIYVLTKTK-IKTPMDIYLLNLAVSDLLFVMTL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 125 PFWAVDAVA-NWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP 203
Cdd:PHA03087   93 PFQIYYYILfQWSFGEFACKIVSGLYYIGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 204 DFIFANVSEADDRYICDRFYPND--LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS-KGHQKRKALKTTVILILA 280
Cdd:PHA03087  173 ILFVYTTKKDHETLICCMFYNNKtmNWKLFINFEINIIGMLIPLTILLYCYSKILITLKGInKSKKNKKAIKLVLIIVIL 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 281 FFACWLPYYIGISIDSFILLEiIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGaKFKTSAQHALTSVSRGSSLK 360
Cdd:PHA03087  253 FVIFWLPFNVSVFVYSLHILH-FKSGCKAVKYIQYALHVTEIISLSHCCINPLIYAFVS-EFFNKHKKKSLKLMFTSSGK 330

                  ....*
gi 1127774881 361 ILSKG 365
Cdd:PHA03087  331 SISIG 335
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
72-346 3.75e-51

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 172.63  E-value: 3.75e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15193     1 IYIPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGgqWLFGEGLCKLSSFII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDryiCDRfYPNDLWV 229
Cdd:cd15193    81 AVNRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLINESV---CVE-DSSSRFF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKL------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15193   157 QGISLATLFLTFVLPLIVILFCYCSILVRLrrhfhgAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLELGGG 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15193   237 VLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFRRRA 279
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
73-346 3.89e-49

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 167.25  E-value: 3.89e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd15381     2 FQPIYLWIIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNgfNWPFGEFLCKSVNAVIY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI--CDRFYPNDLW 228
Cdd:cd15381    82 MNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNItaCVLDYPSEGW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQ------KRKALKTTVILILAFFACWLPYYIGISIDSFILLEI 302
Cdd:cd15381   162 HVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKfkeiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLHKLGL 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 303 IkQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15381   242 I-SGCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFRKKA 284
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
72-345 3.13e-48

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 165.47  E-value: 3.13e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd14993     1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYrPWVFGEVLCKAVPYLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD-------RYICDRF 222
Cdd:cd14993    81 GVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISsepgtitIYICTED 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG----------------HQKRKALKTTVILILAFFACWL 286
Cdd:cd14993   161 WPSPELRKAYNVALFVVLYVLPLLIISVAYSLIGRRLWRRKPpgdrgsanstssrrilRSKKKVARMLIVVVVLFALSWL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 287 PYYI-GISIDSFILLEIikqgcEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14993   241 PYYVlSILLDFGPLSSE-----ESDENFLLILPFAQLLGYSNSAINPIIYCFMSKKFRRG 295
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
72-345 6.18e-48

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 164.17  E-value: 6.18e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd15093     1 VLIPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLPFLAASnALRHWPFGSVLCRLVLSVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-ADDRYICDRFYPN--DL 227
Cdd:cd15093    81 INMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGTREnQDGSSACNMQWPEpaAA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFIL 299
Cdd:cd15093   161 WSAGFIIYTFVLGFLLPLLIICLCYLLIVIKVksaglragWQQRKRSERKVTRMVVMVVVVFVICWLPFYVLQLVNVFVQ 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 300 LeiikQGCEFENTVHKWISIteaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15093   241 L----PETPALVGVYHFVVI---LSYANSCANPILYGFLSDNFKKS 279
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
77-345 4.24e-47

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 162.29  E-value: 4.24e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLR--SMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVN 152
Cdd:cd14976     6 VYMVVFTVGLLGNLLVLYLLKSNKKLRqqSESNKFVFNLALTDLIFVLTLPFWAVEYALDfvWPFGTAMCKVVRYVTKLN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVS-EADDRYICDRFYPNDL---- 227
Cdd:cd14976    86 MYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIFSTDTwSSVNHTLCLLRFPKNSsvtr 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 ---WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG---HQKRKALKTTVILILAFFACWLPYYIGISIDSFILLE 301
Cdd:cd14976   166 wynWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQRKRGgskRRKSRVTKSVFIVVLSFFICWLPNQALSLWSALIKFD 245
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 302 IIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14976   246 DVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFRDA 289
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
72-343 9.99e-47

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 161.08  E-value: 9.99e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15088     1 VIMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDgqWYFGEVMCKIITALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD-RYICDRFYPNDLW 228
Cdd:cd15088    81 ANNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDgTTFCYVSLPSPDD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKL-------SHSKGHQKRKALKTTVILI-LAFFACWLPYYigisIDSFILL 300
Cdd:cd15088   161 LYWFTIYHFILGFAVPLVVITVCYILILHRLargvapgNQSHGSSRTKRVTKMVILIvVVFIVCWLPFH----VVQLVNL 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 301 EIIKQGCEFEntVHKWISIteALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15088   237 AMNRPTLAFE--VAYFLSI--CLGYANSCLNPFVYILVSENFR 275
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
74-344 1.29e-46

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 160.71  E-value: 1.29e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYTV 151
Cdd:cd15189     3 IPPFIFSLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNqfNWPFGELLCRVVNGVIKV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI--CDRFYPNDLWV 229
Cdd:cd15189    83 NLYTSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNItaCVLLYPHEAWH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSH---SKGHQKRKALKTTVI---LILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15189   163 FAHIVLLNIVGFLLPLLVITFCNYNILQALRTreeSTRCEDRNDSKATALvlaVTLLFLVCWGPYHFFTFLDFLFDVGVL 242
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 304 KqGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15189   243 D-ECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFRR 282
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
74-346 2.16e-45

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 157.65  E-value: 2.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWA--VDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15380     3 LPTFIIAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAenIRNQFNWPFGNFLCRVISGVIKA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI--CDRFYPNDLWV 229
Cdd:cd15380    83 NLFISIFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIPTFLFRSVKHVPDLNIsaCILLFPHEAWH 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILP--GIVILScYCIIISKLSHSKGHQKR-------KALKTTVILILAFFACWLPYYIGISIDSFILL 300
Cdd:cd15380   163 FARRVELNIVGFLLPlaAIVFFN-FHIIASLRERTEESRKRcgglkdtKATRLILTLVLMFLVCWTPYHFFAFLDFLFQV 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 301 EIIkQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15380   242 EVI-QGCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFRTKV 286
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
77-345 2.39e-45

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 157.18  E-value: 2.39e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15114     6 LYAVVFLVGVPGNALVAWVTGFEAK-RSVNAVWFLNLAVADLLCCLSLPILAVPIAqdGHWPFGAAACKLLPSLILLNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA--DDRYICDRFYPND----LW 228
Cdd:cd15114    85 ASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEhfPEKTVCVVDYGGStgveWA 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFqhiMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidSFILLEIIKQGCE 308
Cdd:cd15114   165 VAIIRF---LLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHV-----VGLIIAASAPNSR 236
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15114   237 LLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKS 273
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
72-345 7.17e-45

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 155.84  E-value: 7.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV-ANWYFGNFLCKAVHVIYT 150
Cdd:cd15970     1 ILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLlRHWPFGSLLCRLVLSVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI-CDRFY--PNDL 227
Cdd:cd15970    81 INMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAPNSDGSVaCNMQMpePSQR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKL---SHSKGHQKRKALKTTVIL-----ILAFFACWLPYYIGISIDSFIl 299
Cdd:cd15970   161 WLAVFVVYTFLMGFLLPVIAICLCYILIIVKMrvvALKAGWQQRKRSERKITLmvmmvVTVFVICWMPFYVVQLVSVFV- 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 300 leiikqgcEFENTVHKWISIteALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15970   240 --------GQHDATVSQLSV--ILGYANSCANPILYGFLSDNFKRS 275
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
72-343 5.48e-44

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 153.77  E-value: 5.48e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFwAVDAVA---NWYFGNFLCKAVHVI 148
Cdd:cd15116     1 ILSMVIYSVVFVLGVLGNGLVIFITGFKMK-KTVNTVWFLNLAVADFLFTFFLPF-SIAYTAmdfHWPFGRFMCKLNSFL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL- 227
Cdd:cd15116    79 LFLNMFTSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNNFSLs 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 ------WVVVFQFQHIMV--------GLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgis 293
Cdd:cd15116   159 gdnsspEVNQLRNMRHQVmtitrfllGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHI--- 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 294 idsFILLEiIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15116   236 ---LNLLE-MEATRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFK 281
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
77-344 2.06e-43

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 152.20  E-value: 2.06e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWaVDAVA---NWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15119     6 IYIVAFVLGVPGNAIVIWVTGFKWK-KTVNTLWFLNLAIADFVFVLFLPLH-ITYVAldfHWPFGVWLCKINSFVAVLNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-ADDRYIC-DRFYPNDLWVVV 231
Cdd:cd15119    84 FASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTMElSINVTICfNNFHKHDGDLIV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQfQHIMV------GLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEI-IK 304
Cdd:cd15119   164 MR-HTILVwvrfffGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYHI------FSILELsIH 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 305 QGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15119   237 HSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKA 276
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
72-338 4.63e-43

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 151.55  E-value: 4.63e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15194     1 GFLPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLgpWRSGSFLCKGSSYII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYIC--DRFYPNDl 227
Cdd:cd15194    81 SVNMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLPTLLSRELKKYEEKEYCneDAGTPSK- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 wvVVFQFQHIMVGLILPGIVILSCYCIIISKLSH----SKGHQK--RKALKTTVILILAFFACWLPYYIgisidsFILLE 301
Cdd:cd15194   160 --VIFSLVSLIVAFFLPLLSILTCYCTIIWKLCHhyqkSGKHQKklRKSIKIVFIVVAAFVFSWMPFNL------FKALA 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 302 IIkQGCEFENTVHKW------ISITEALAFFHCCLNPILYAFL 338
Cdd:cd15194   232 IA-SGLQVEVTCLPYtlaqlgMEVSAPLAFANSCANPFIYYFF 273
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
75-343 6.46e-43

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 151.28  E-value: 6.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVD-AVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15095     4 PLIFAIIFLVGLAGNSLVIYVVSRHREMRTVTNYYIVNLAVTDLAFlVCCVPFTAALyATPSWVFGDFMCKFVNYMMQVT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEAD---DRYICDRFYPNDLWV 229
Cdd:cd15095    84 VQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYwygPQTYCREVWPSKAFQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH--------------QKRKALKTTVILILAFFACWLPYYIgisid 295
Cdd:cd15095   164 KAYMIYTVLLTYVIPLAIIAVCYGLILRRLWRRSVDgnnqseqlseralrQKRKVTRMVIVVVVLFAICWLPNHV----- 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 296 sFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15095   239 -LNLWQRFDPNFPETYATYALKIAALCLSYANSAVNPFVYAFMGENFR 285
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
77-346 7.05e-43

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 150.30  E-value: 7.05e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15115     6 VLSLTFLLGVPGNGLVIWVAGLKMK-RTVNTIWFLNLAVADLLCCLSLPFSIAHLLLNghWPYGRFLCKLLPSIIVLNMF 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYpndlwVVVFQF 234
Cdd:cd15115    85 ASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVTDGNHTRCGYDF-----LVAITI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVGLILPGIVILSCYCIIISKLSHSKGHQK-RKALKTTVILILAFFACWLPYYIgisidsfILLEIIKQGCEFENTV 313
Cdd:cd15115   160 TRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSqSKTFRVIIAVVVAFFVCWAPYHI-------IGILSLYGDPPLSKVL 232
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 314 HKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15115   233 MSWDHLSIALAYANSCLNPVLYVFMGKDFKKKA 265
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
72-345 1.14e-42

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 150.34  E-value: 1.14e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV-DAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15974     1 VLIPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLPFLATqNAISYWPFGSFLCRLVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEadDRYICDRFYPN--DLW 228
Cdd:cd15974    81 VNQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIFSDVQP--DLNTCNISWPEpvSVW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS--------KGHQKRKALKTTVILILAFFACWLPYYI-GISIDSFIL 299
Cdd:cd15974   159 STAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSglrvgstkRRKSERKVTRMVVIIVVVFVFCWLPFYMlNIVNLIVIL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 300 LEiikqgcefENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15974   239 PE--------EPAFVGVYFFVVVLSYANSCANPILYGFLSDNFKQS 276
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
77-345 1.22e-42

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 150.01  E-value: 1.22e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15973     6 IYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASaALQHWPFGSAMCRTVLSVDGINMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI-CDRFYPNDLWVVVFQF 234
Cdd:cd15973    86 SVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVaCNLIWPHPAWSAAFVI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVGLILPGIVILSCYCIIISKL---SHSKGHQKR-----KALKTTVILILAFFACWLPYYIGISIDSFIlleiikqg 306
Cdd:cd15973   166 YTFLLGFLLPVLAIGLCYILIIGKMravALKAGWQQRrksekKITRMVLMVVTVFVICWMPFYVVQLLNLFL-------- 237
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 307 CEFENTVHKWISIteaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15973   238 PRLDATVNHASLI---LSYANSCANPILYGFLSDNFRRS 273
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
72-345 2.29e-42

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 149.61  E-value: 2.29e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd15971     1 AFLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQvALVHWPFGKAICRVVMTVDG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYP--NDLW 228
Cdd:cd15971    81 INQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQTKHGRSSCTIIWPgeSSAW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSK---GHQKRKALKTTV-----ILILAFFACWLPYYI--GISIDSFI 298
Cdd:cd15971   161 YTGFIIYTFILGFFVPLTIICLCYLFIIIKVKSSGirvGSSKRKKSEKKVtrmvsIVVAVFVFCWLPFYIfnVSSVSVSI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1127774881 299 LLEIIKQGCeFENTVhkwisiteALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15971   241 SPTPGLKGM-FDFVV--------VLSYANSCANPILYAFLSDNFKKS 278
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
77-343 1.04e-41

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 147.96  E-value: 1.04e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFwAVDAVA---NWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15117     6 IYSSAFVLGTLGNGLVIWVTGFRMT-RTVTTVCFLNLAVADFAFCLFLPF-SVVYTAlgfHWPFGWFLCKLYSTLVVFNL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFY--PN------ 225
Cdd:cd15117    84 FASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRKENGCTHCYLNFdpWNetaedp 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHI-------MVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYigisIDSFI 298
Cdd:cd15117   164 VLWLETVVQRLSaqvitrfVLGFLVPLVIIGGCYGLIAARLWREGWVHSSRPFRVLTAVVAAFFLCWFPFH----LVSLL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 299 LLEIIKQGCEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15117   240 ELVVILNQKEDLNPLLILLlPLSSSLACVNSCLNPLLYVFVGRDFR 285
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
76-345 1.54e-41

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 146.55  E-value: 1.54e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd14967     4 VFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLvMPFSAVYTLLGyWPFGPVLCRFWIALDVLCC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQ 233
Cdd:cd14967    84 TASILNLCAISLDRYLAITRPLRYRQLMTKKRALIMIAAVWVYSLLISLPPLVGWRDETQPSVVDCECEFTPNKIYVLVS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FqhiMVGLILPGIVILSCYCIIISKLSHskghqKRKALKTTVILILAFFACWLPYYIGISIDSFilleiikqgCEFENTV 313
Cdd:cd14967   164 S---VISFFIPLLIMIVLYARIFRVARR-----ELKAAKTLAIIVGAFLLCWLPFFIIYLVSAF---------CPPDCVP 226
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1127774881 314 HKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14967   227 PILYAVFFWLGYLNSALNPIIYALFNRDFRRA 258
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
72-343 2.52e-41

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 146.79  E-value: 2.52e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKL--RSMTDKYRLHLSVADLLFVI-TLPFWA-VDAVANWYFGNFLCKAVHV 147
Cdd:cd15098     1 VIVPVVFGLIFCLGVLGNSLVITVLARVKPGkrRSTTNVFILNLSIADLFFLLfCVPFQAtIYSLPEWVFGAFMCKFVHY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRK----LLAEKVvyvgVWIPALLLTIP---DFIFANVSEADDRYICD 220
Cdd:cd15098    81 FFTVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTrrnaLLGVLV----IWVLSLAMASPvavHQDLVHHWTASNQTFCW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 221 RFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL-------SHSKGHQKRKALKTTVILILAFFACWLPYYIgis 293
Cdd:cd15098   157 ENWPEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVLNHLhkklknmSKKSERSKKKTAQTVLVVVVVFGISWLPHHI--- 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 294 idsfilleiikqgcefentVHKWIS---------------ITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15098   234 -------------------IHLWVEfgdfpltqasfvlriTAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
76-345 3.11e-41

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 146.47  E-value: 3.11e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd14975     5 TLLSLAFAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFlATGTWDFGLAACKGCVYVCAVSMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPR-KLLAEKVVYVgVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQ 233
Cdd:cd14975    85 ASVFLITLMSLERFLAVSRPFVSQGWRaKALAHKVLAI-IWLLAVLLATPVIAFRHVEETVENGMCKYRHYSDGQLVFHL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTV 313
Cdd:cd14975   164 LLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGGSKMAGTLGKV 243
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 314 HKWIS-ITEALAFFHCCLNPILYAFLGAK-FKTS 345
Cdd:cd14975   244 AEAGRpIAGALAFLSSSINPLLYAFAARGlFRSA 277
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
73-343 4.40e-41

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 146.11  E-value: 4.40e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYT 150
Cdd:cd15921     2 FYPTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVlnSHWPFGDIACRIILYVLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFANvSEADDRYICDRFYPNDLWVV 230
Cdd:cd15921    82 VNMYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSP-LLFAK-SKQHDEGSTRCLELAHDAVD 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQH---IMVGLILPGIVILSCYCIIISKLSHSKGHQK------RKALKTTVILILAFFACWLPYYIGISIdSFILLE 301
Cdd:cd15921   160 KLLLINyvtLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGrtrpsrRKACALIIISLGIFLVCFLPYHIVRTI-HLITER 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 302 IIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15921   239 QIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFR 280
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
72-345 4.90e-41

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 146.08  E-value: 4.90e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDA-VANWYFGNFLCKAVHVIYT 150
Cdd:cd15094     1 LISAVLYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMiLKYWPFGAAMCKIYMVLTS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV- 229
Cdd:cd15094    81 INQFTSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYSCTIVWPDSSAVn 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 --VVFQFQHIMVGLILPGIVILSCYCIIISKLS------HSKGHQK--RKALKTTVILILAFFACWLPYYIGISidSFIL 299
Cdd:cd15094   161 gqKAFTLYTFLLGFAIPLLLISVFYTLVILRLRtvgpknKSKEKRRshRKVTRLVLTVISVYIICWLPYWAFQV--HLIF 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 300 LEIIKQGCEFENTVHKwisITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15094   239 LPPGTDMPKWEILMFL---LLTVLSYANSMVNPLLYAFLSENFRKS 281
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
72-343 6.12e-41

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 146.21  E-value: 6.12e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd15203     1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTkNWPFGSILCKLVPSLQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATnsQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEAD------DRYICDRFY 223
Cdd:cd15203    81 GVSIFVSTLTLTAIAIDRYQLIVYPT--RPRMSKRHALLIIALIWILSLLLSLPLAIFQELSDVPieilpyCGYFCTESW 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNDLW-------VVVFQFqhimvglILPGIVILSCY---CIIISKLSHSKGHQKRKAL-----------KTTVILI---L 279
Cdd:cd15203   159 PSSSSrliytisVLVLQF-------VIPLLIISFCYfriSLKLRKRVKKKRGKRTLSSrrrrselrrkrRTNRLLIamvV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 280 AFFACWLPYYI-GISIDSFILLEIIKQGCEFENTVHKWISITEAlaffhcCLNPILYAFLGAKFK 343
Cdd:cd15203   232 VFAVCWLPLNLfNLLRDFEPLPQIDGRHFYLIFLICHLIAMSSA------CVNPLLYGWLNDNFR 290
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
56-343 9.88e-41

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 148.62  E-value: 9.88e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  56 SMKEPCFREENANFNKIFlptiYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANW 135
Cdd:PHA02638   87 NIKNKCMYPSISEYIKIF----YIIIFILGLFGNAAIIMIL-FCKKIKTITDIYIFNLAISDLIFVIDFPFIIYNEFDQW 161
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 136 YFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPD-FIF------- 207
Cdd:PHA02638  162 IFGDFMCKVISASYYIGFFSNMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAyFIFeasniif 241
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 208 --ANVSEADDRYICDRFYPNDLWVVVF-----QFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILA 280
Cdd:PHA02638  242 saQDSNETISNYQCTLIEDNEKNNISFlgrilQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIIC 321
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 281 FFACWLPYYIGISIDSFILLE-----IIKQGCEFENTVHKWIsITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:PHA02638  322 SLICWIPLNIVILFATMYSFKgfnsiISEHICGFIKLGYAMM-LAEAISLTHCCINPLIYTLIGENFR 388
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
72-343 2.39e-40

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 144.27  E-value: 2.39e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLR-SMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVI 148
Cdd:cd15926     1 IIISIVYSVVCALGLVGNLLVLYLMKSKQGWKkSSINLFVTSLAVTDFQFVLTLPFWAVENALdfTWLFGKAMCKIVSYV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL- 227
Cdd:cd15926    81 TAMNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVSNEELCLVKFPDNRg 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 ----WVVVFQFQHIMVGLILPGIVILSCYCIII-----SKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFI 298
Cdd:cd15926   161 naqfWLGLYHAQKVLLGFLIPLGIISLCYLLLVrfitdKNITGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 LLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15926   241 KLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFR 285
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
72-337 3.70e-40

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 143.65  E-value: 3.70e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLP----FWAVDAvaNWYFGNFLCKAVHV 147
Cdd:cd15159     1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPgriaYYALGF--DWPFGDWLCRLTAL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRfYPNdl 227
Cdd:cd15159    79 LFYINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLPLLFMPMTKEMGGRITCME-YPN-- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHI-----MVGLILPGIVILSCYCIIISKLSHS---------KGHQKrKALKTTVILILAFFACWLPYYIGIS 293
Cdd:cd15159   156 FEKIKRLPLIllgacVIGFGVPVGIILFCYSQITLKLCRTakenpltekSGHHK-KACNVILLVLLVFVVCFSPYHLNII 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 294 idSFILLEIIKQ-GCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15159   235 --QFMIRKLLYQpSCSELKAFKISLQITVCLMNLNCCLDPFIYFF 277
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
75-343 5.48e-40

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 143.38  E-value: 5.48e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWAVD-AVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd14971     4 PLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLfCVPFTATIyPLPGWVFGDFMCKFVHYFQQVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRFYPNDLWVV 230
Cdd:cd14971    84 MHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNytPGNRTVCSEAWPSRAHRR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLE 301
Cdd:cd14971   164 AFALCTFLFGYLLPLLLICVCYAAMLRHLwrvavrpvlSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLVALGPFP 243
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 302 IIKQGCEFENTVHkwisiteALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14971   244 LTYATYALRIWAH-------CLAYSNSAVNPVLYAFLSEHFR 278
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
76-344 1.86e-39

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 141.81  E-value: 1.86e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15158     5 TLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVhkGQWLFGDFLCRISSYALYVNL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICdrFYPND-----LW 228
Cdd:cd15158    85 YCSIYFMTAMSFTRFLAIVFPVQNLNLVTVKKARIVCVGIWIFVTLTSSPFLMSGSHDTETNKTKC--FEPPQsnqqlTK 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIII-SKLSHSKGHQK-----RKALKTTVILILAFFACWLPYYIGISIdSFILLEI 302
Cdd:cd15158   163 LLVLNYISLVVGFIIPFLVILICYAMIIrTLLKNTMKARKqqssrKKAIRMIIIVLLAFLVSFMPYHIQRTI-HLHFLSR 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15158   242 KDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRR 283
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
72-343 4.33e-39

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 140.71  E-value: 4.33e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV-DAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15972     1 VLIPLVYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAqNALSYWPFGSFMCRLVMTVDA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV 230
Cdd:cd15972    81 INQFTSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGTCHIAWPEPAQVWRA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISK----------LSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsfilL 300
Cdd:cd15972   161 GFIIYTATLGFFCPLLVICLCYLLIVVKvrssgrrvraTSTKRRGSERKVTRMVVIVVAAFVLCWLPFYA---------L 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 301 EIIKQGCEF--ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15972   232 NIVNLVCPLpeEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFK 276
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
72-343 5.00e-39

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 140.78  E-value: 5.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQK-KLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVI 148
Cdd:cd15925     1 ILVALAYGLVCAIGLLGNLAVMYLLRNCArRAPPPIDVFVFNLALADFGFALTLPFWAVESALDfhWPFGGAMCKMVLTA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW 228
Cdd:cd15925    81 TVLNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIFATEGEVCGVELCLLKFPSNYW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTV-----ILILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15925   161 LGAYHLQRVVVAFVVPLGVITTSYLLLLSFLQQHKVNQNNRQRQSVIarsvrLVVASFFLCWFPNHVVTFWGVLVKFRAV 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 304 KQGCEFEnTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15925   241 PWNSTFY-FIHTYVfPVTTCLAHSNSCLNPVLYCLMRREFR 280
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
72-343 5.32e-39

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 140.68  E-value: 5.32e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd14988     1 VVLFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDytWLWGSFLCKFTHYFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR--YICDRFYPNDL 227
Cdd:cd14988    81 FANMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGVEPmcLFLAPFETYDE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISI----DSFILLEii 303
Cdd:cd14988   161 WALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLltlhGSHISLH-- 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 kqgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14988   239 ---CNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFR 275
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
72-345 7.95e-39

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 140.12  E-value: 7.95e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd15096     1 IVVPVIFGLIFIVGLIGNSLVILVVLSNQQMRSTTNILILNLAVADLLFVVfCVPFTATDYVLpTWPFGDVWCKIVQYLV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllaEKVVY---VGVWIPALLLTIPDFIFANVSEADDrYICDRFYPND 226
Cdd:cd15096    81 YVTAYASVYTLVLMSLDRYLAVVHPITSMSIRT---ERNTLiaiVGIWIVILVANIPVLFLHGVVSYGF-SSEAYSYCTF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVV-----VFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH----------QKRKALKTTVILILAFFACWLPYYIG 291
Cdd:cd15096   157 LTEVgtaaqTFFTSFFLFSYLIPLTLICVLYMLMLRRLRRQKSPggrrsaesqrGKRRVTRLVVVVVVVFAICWLPIHII 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 292 ISIDSFILLEiikqgcefENTVHKWISIT-EALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15096   237 LLLKYYGVLP--------ETVLYVVIQILsNCLAYGNSCVNPILYAFLSQNFRKA 283
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
72-338 5.31e-38

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 137.90  E-value: 5.31e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWaVDAVA---NWYFGNFLCKAVHVI 148
Cdd:cd15160     1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLW-IDYTAnhhNWTFGPLSCKVVGFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY-ICDRFYPNDL 227
Cdd:cd15160    80 FYTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRDEPNHtLCYEKYPMEG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG---HQKRKALKTTVILILAFFACWLPYYIGISIDSFILLeIIK 304
Cdd:cd15160   160 WQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSlerEEKRKIIGLLLSIVVIFLLCFLPYHVVLLVRSVIEL-VQN 238
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 305 QGCEFENTVHKWISITEALAFFHCCLNPILYAFL 338
Cdd:cd15160   239 GLCGFEKRVFTAYQISLCLTSLNCVADPILYIFV 272
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
72-342 6.28e-38

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 137.99  E-value: 6.28e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15968     1 ILLPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRdrWLFGDFMCRLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15968    81 YFNLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFARTGIIRNRTVCYDLAPPALFP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHI--MVGLILPGIVILSCYCIIISKLSHSKG-------HQKRKALKTTVILILAFFACWLPYYIGISIdsFILL 300
Cdd:cd15968   161 HYVPYGMAltVSGFLLPFSIILWCYCLVVRTLCRTLGpaeppaqARRRKSIRTIVTVTLLFALCFLPFHITRTI--YLAV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 301 EIIKQ-GCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15968   239 RVTPGvPCHVLEAVAACYKITRPLASANSVLNPLLYFLTKKKF 281
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
76-346 4.11e-37

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 135.71  E-value: 4.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWA-VDAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15121     5 AILSLAFILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLhFLSGGGWEFGSVVCKLCHYVCGVSMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP-DFIFANVSEADDRYICDRFYPNDLWVVVFQ 233
Cdd:cd15121    85 ASIFLITLMSMDRCLAVAKPFLSQKMRTKRSVRALLLAIWIVAFLLSLPmPFYRTVLKKNINMKLCIPYHPSVGHEAFQY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTV 313
Cdd:cd15121   165 LFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAA 244
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 314 HKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15121   245 KLARPNVTALAFLSSSVNPVLYAFAGGSLIRSA 277
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
61-343 1.04e-36

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 135.80  E-value: 1.04e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  61 CFREENANFNKI------FLPTIYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN 134
Cdd:PHA02834   12 YYFEEECDFEMVnsdvnyFVIVFYILLFIFGLIGNVLVIAVL-IVKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDLNE 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 135 WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSqRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEAD 214
Cdd:PHA02834   91 WIFGEFMCKLVLGVYFVGFFSNMFFVTLISIDRYILVVNATKI-KNKSISLSVLLSVAAWVCSVILSMPAMVLYYVDNTD 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 215 --DRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGI 292
Cdd:PHA02834  170 nlKQCIFNDYHENFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVL 249
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 293 SIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:PHA02834  250 FINSLQSVGLIDIGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFK 300
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
79-337 1.81e-36

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 134.43  E-value: 1.81e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd14986     8 GVLFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVvaFFTVLTQIIWEATGEWVAGDVLCRIVKYLQVVGLFAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKlLAEKVVYVGvWIPALLLTIPD-FIFANVSEADDRYIC-DRFYPNDLWVVVFQF 234
Cdd:cd14986    88 TYILVSMSLDRYQAIVKPMSSLKPRK-RARLMIVVA-WVLSFLFSIPQlVIFVERELGDGVHQCwSSFYTPWQRKVYITW 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVgLILPGIVILSCYCIIISKL-SHSKGHQKR---------------------------KALKTTVILILAFFACWL 286
Cdd:cd14986   166 LATYV-FVIPLIILSYCYGRILRTIwIRSRQKTDRpiaptamscrsvscvssrvslisrakiKTIKMTLVIILAFILCWT 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 287 PYYIgisidsFILLEIIKQGCEFENTVhkwISITEALAFFHCCLNPILYAF 337
Cdd:cd14986   245 PYFI------VQLLDVYAGMQQLENDA---YVVSETLASLNSALNPLIYGF 286
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
72-343 2.20e-36

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 133.68  E-value: 2.20e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15161     1 ILFALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSgnHWPFGEVPCRLAGFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFY--PNDL 227
Cdd:cd15161    81 YLNMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVEVNNTTVCLQLYreKASR 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVfqfqHIMVGLILPGIVILSCYCIIISKLSHSKG---HQKRKALKTTVILILAFFACWLPYYIGISIdsFILL-EII 303
Cdd:cd15161   161 GALV----SLAVAFTIPFVTTVTCYLLIIRSLRTGKReekPLKDKAIKMIILVLTIFLICFVPYHISRYI--YILShNGA 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15161   235 GASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFR 274
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
76-345 3.65e-36

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 132.78  E-value: 3.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV-ITLPF-WAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15001     4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLvFCVPLkTAEYFSPTWSLGAFLCKAVAYLQLLSF 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFANVSEADDR------YICDRFYPNDL 227
Cdd:cd15001    84 ICSVLTLTAISIERYYVILHPMKAKSFCTIGRARKVALLIWILSAILASP-VLFGQGLVRYESengvtvYHCQKAWPSTL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYciiisklshskGHQKRKAL-KTTVILILAFFACWLPYYIGISIDSFILLEIIkqg 306
Cdd:cd15001   163 YSRLYVVYLAIVIFFIPLIVMTFAY-----------ARDTRKQViKMLISVVVLFAVCWGPLLIDNLLVSFDVISTL--- 228
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 307 ceFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15001   229 --HTQALKYMRIAFHLLSYANSCINPIIYAFMSKNFRSS 265
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
73-343 4.37e-36

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 132.89  E-value: 4.37e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVmgYQKKLRSMTDK--YRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVI 148
Cdd:cd15375     2 YLPVMYSIIFIVGFPGNIIAIFV--YLFKMRPWKSStiIMLNLALTDLLYVTSLPFLIYYYINgeSWIFGEFMCKFIRFI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW 228
Cdd:cd15375    80 FHFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKEKNNRTICLDFTSSDNL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIM--VGLILPGIVILSCYCIIISKLS---HSKGHQKRKALKTTVILILAFFACWLPYYI--GISIDsfilLE 301
Cdd:cd15375   160 NTIWWYNWILtvLGFLLPLVIVTLCYTRIIYTLAkgpHTGSASKQKARRLIILILLVFYVCFLPFHIlrVVRIE----TR 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 302 IIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15375   236 LPPVSCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQ 277
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
75-343 5.92e-36

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 132.53  E-value: 5.92e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKK--LRSMTDKYRLHLSVADLLFVI-TLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd15002     3 PILLGVICLLGFAGNLMVIGILLNNARkgKPSLIDSLILNLSAADLLLLLfSVPFRAAAySKGSWPLGWFVCKTADWFGH 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATnSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY--ICDRFYPNDLW 228
Cdd:cd15002    83 ACMAAKSFTIAVLAKACYMYVVNPT-KQVTIKQRRITAVVASIWVPACLLPLPQWLFRTVKQSEGVYlcILCIPPLAHEF 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKL--SHSKGH------QKRKALKTTVILILAFFACWLPYYIgisidsfILL 300
Cdd:cd15002   162 MSAFVKLYPLFVFCLPLTFALFYFWRAYGQCqrRGTKTQnlrnqiRSRKLTHMLLSVVLAFTILWLPEWV-------AWL 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 301 EIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15002   235 WLIHIKSSGSSPPQLFNVLAQLLAFSISSVNPIIFLLMSEEFR 277
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
77-343 4.39e-35

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 130.37  E-value: 4.39e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15092     6 VYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFLGfWPFGNALCKTVIAIDYYNMFT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYIC--DRFYPNDLWVVVFQ 233
Cdd:cd15092    86 STFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVPVMVMGSAQVEDEEIEClvEIPTPQDYWDPVFG 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPyyigisIDSFILLEIIKQ 305
Cdd:cd15092   166 ICVFLFSFIIPVLIISVCYSLMIRRLrgvrllsgSKEKDRNLRRITRLVLVVVAVFVGCWTP------IQIFVLAQGLGV 239
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 306 GCEFENTVhKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15092   240 QPSSETAV-AILRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
73-343 4.49e-35

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 130.22  E-value: 4.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIYT 150
Cdd:cd15157     2 IYPTVYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLmgSHWVFGDIACRIMSYSLY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFANVSEADDRYICDRFYPNDL-WV 229
Cdd:cd15157    82 VNMYCSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSP-LLSKGTSKYNSQTKCLDLHPSKIdKL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKR------KALKTTVILILAFFACWLPYYIgisIDSFILLEII 303
Cdd:cd15157   161 LILNYIVLVVGFILPFCTLSICYILIIKALLKPRVPQSKlrvshkKALLTIIITLILFLLCFLPYHI---LRTVHLMQWS 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEFEntVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15157   238 EGQCNLR--LHKAVVITLCLAAANSCLDPLLYYFAGENFK 275
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
72-343 7.68e-35

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 129.69  E-value: 7.68e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYT 150
Cdd:cd15091     1 VIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNsWPFGDVLCKIVISIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFA--NVSEADDRYICDRFYPNDL- 227
Cdd:cd15091    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGgtKVREDVDSTECSLQFPDDDy 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 --WVVVFQFQHIMVGLILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsF 297
Cdd:cd15091   161 swWDTFMKICVFIFAFVIPVLIIIVCYTLMILRLksvrllsgSREKDRNLRRITRLVLVVVAVFVVCWTPIHI------F 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 298 ILLEIIKQGCEFENTVHKWIsITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15091   235 ILVEALGSVSHSTAAVSSYY-FCIALGYTNSSLNPILYAFLDENFK 279
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
78-344 1.10e-34

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 129.28  E-value: 1.10e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15207     7 YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVgVFCMPFTLVDNIlTGWPFGDVMCKLSPLVQGVSVAA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATnsqRPRKLLAE-KVVYVGVWIPALLLTIPDFIFANV-----SEADDRYICDRFYPNDLWV 229
Cdd:cd15207    87 SVFTLVAIAVDRYRAVVHPT---EPKLTNRQaFVIIVAIWVLALAIMIPQALVLEVkeyqfFRGQTVHICVEFWPSDEYR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH---------------QKRKALKTTVILILAFFACWLPYYIGISI 294
Cdd:cd15207   164 KAYTTSLFVLCYVAPLLIIAVLYVRIGYRLWFKPVPgggsasreaqaavskKKVRVIKMLIVVVVLFALSWLPLHTVTML 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 295 DSFILLEIIKQGcefenTVHKWI-SITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15207   244 DDFGNLSPNQRE-----VLYVYIyPIAHWLAYFNSCVNPIVYGYFNRNFRK 289
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
80-342 2.53e-34

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 128.38  E-value: 2.53e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLT-----GIVGNGLVI--LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFW-AVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15122     4 TIFLLlaallGLPGNGFIIwsILWKMKARGRSVTCILILNLAVADGAVLLLTPFFiTFLTRKTWPFGQAVCKAVYYLCCL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV--SEADDRYICDRFYPNDLWV 229
Cdd:cd15122    84 SMYASIFIIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVwkDEGMNDRICEPCHASRGHA 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLeiiKQGCEF 309
Cdd:cd15122   164 IFHYTFETLVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANL---APGEVL 240
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 310 ENTVHKWISI---TEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15122   241 EKLGGAAKAAragATALAFFSSSVNPLLYVFAAGDL 276
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
72-335 4.73e-34

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 127.57  E-value: 4.73e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd16001     1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRdrWPFGDFLCKLVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNS--QRPRKLLAEKVvyVGVWIPALLLTIPDFIFANVSEADDRYIC------DR 221
Cdd:cd16001    81 YTNLYGSILFLTCISVHRFLGVCYPIRSlaYRTRRLAVIGS--AATWILVVLQLLPTLVYARTGSINNRTVCydltspDN 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQfqhiMVGLILPGIVILSCYCIIISKLSHSKGHQ------KRKALKTTVILILAFFACWLPYYIGISID 295
Cdd:cd16001   159 FGNYFPYGMVLT----VTGFLIPFLIILLCYCLMIKSLIRSEEAAgvgkaaRAKSIRTILLVCGLFALCFVPFHITRTIY 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 296 SFILLEIIkQGCEFENTVHKWISITEALAFFHCCLNPILY 335
Cdd:cd16001   235 LFVRVYLV-QDCPLLQFVSLAYKIWRPLVSFNSCINPLLY 273
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
74-342 9.78e-34

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 126.48  E-value: 9.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15171     3 VPQLCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWAHAAWHGGSLGNPTCKVLVALSSVGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGV-WIPALLLTIPDFIFANVSEADDRYICD----RFYPND-- 226
Cdd:cd15171    83 HSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIASVLaWLTAFLVTLPEFVFYKPQMDSQKSKCAfsrpHFLPAEet 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKghQKRKALKTTVILILAFFACWLPYYIGISIDSFilLEIIK-Q 305
Cdd:cd15171   163 FWKYFLTLKMNIVVLVFPLLVFIICCVQLRKTQRFRE--RQRDLSKLVFAIMVVFLLMWAPYNIALFLSAF--KEHFSlR 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 306 GCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15171   239 DCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAF 275
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
72-345 1.76e-33

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 126.01  E-value: 1.76e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYT 150
Cdd:cd15087     1 VALPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQqWPFGELLCKLILSIDH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRP--RKLLAEKVVYVGVWIPALLLTIPDFIFANV-SEADDRYICDRFYPN-- 225
Cdd:cd15087    81 YNIFSSIYFLTVMSVDRYLVVLATVRSRRMpyRTYRAAKIVSLCVWLLVTIIVLPFTVFAGVySNELGRKSCVLSFPSpe 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKAL----KTTVILILAFFA----CWLPYYIGisidSF 297
Cdd:cd15087   161 SLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRLNSNAKALdkakKKVTLMVLVVLAvclfCWTPFHLS----TV 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 298 ILLEIIKQGCEFENTVHKWISiteALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15087   237 VALTTDLPQTPLVIGISYFIT---SLSYANSCLNPFLYAFLDDSFRKS 281
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
80-345 2.30e-33

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 125.66  E-value: 2.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15120     9 VTFLVGLVVNGLYLWVLGFKMR-RTVNTLWFLHLILSNLIFTLILPFMAVHVLMdnHWAFGTVLCKVLNSTLSVGMFTSV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD-RYICDRFYP------------ 224
Cdd:cd15120    88 FLLTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRETRLDEKgKTICQNNYAlstnwesaevqa 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 --NDLWVVVFQFQHIMvGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYigisidsfillei 302
Cdd:cd15120   168 srQWIHVAMFVFRFLL-GFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYH------------- 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 303 IKQGCEFENTVHKWIS-----ITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15120   234 LHSGLVLTRGRPPSLTditllLTVGTTCFNTCFTPVLYLFVGENFKKV 281
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
77-337 8.53e-33

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 124.19  E-value: 8.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15156     6 VFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQrNWPFGDLLCKISVTLFYTNMYG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRFYPNDLW----- 228
Cdd:cd15156    86 SILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNqlNNNSETCFENFSSKTWktyls 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 -VVVFQFqhiMVGLILPGIVILSCYCIIISKLSH----SKGH-QKRKALKTTVILILAFFACWLPYYIGISIDSFILLEI 302
Cdd:cd15156   166 kIVIFIE---IVGFFIPLILNVTCSTMVLKTLRRpntlSRSKlNKKKVLKMIFVHLFIFCFCFIPYNVNLVLYSLVRTQT 242
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 303 IKqGCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15156   243 FK-NCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
78-343 8.57e-33

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 124.47  E-value: 8.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd14992     7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMaLFCTPFNFTYVVSLsWEYGHFLCKIVNYLRTVSVYA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV----- 230
Cdd:cd14992    87 SSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVKNQEKIFCCQIPPVdnkty 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 -VFQFQHIMVGL-ILPGIVILSCYCIIISKLSHSKG-------------HQKRKALKTTVILILAFFACWLPYYIgisid 295
Cdd:cd14992   167 eKVYFLLIFVVIfVLPLIVMTLAYARISRELWFRKVpgfsikeverkrlKCKRRVIKMLVCVVVLFVICWLPFHL----- 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 296 sFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14992   242 -FFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
72-343 1.35e-32

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 123.76  E-value: 1.35e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLP--FWAVDAVANWYFGNFLCKAVHVIY 149
Cdd:cd15374     1 ILLPVSYGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPtlIYYYADHNHWPFGVVACKIVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYIC-DRFYPNDLW 228
Cdd:cd15374    81 YANLYCSILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFVTTSRKDNITLChDTTRPEEFD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLI-LPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIdsFIL 299
Cdd:cd15374   161 HYVHYSSAVMVLLFgIPCLVIVVCYGLMARRLckprvgssRQQGPSSKKRSLKTIIMVLTVFAICFVPFHITRTL--YYV 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 300 LEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15374   239 ARLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYR 282
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
72-343 2.92e-32

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 122.80  E-value: 2.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd15090     1 ITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNyLMGTWPFGNILCKIVISIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW-- 228
Cdd:cd15090    81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPSWyw 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 -----VVVFQFQHIMvglilPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGIsid 295
Cdd:cd15090   161 enllkICVFIFAFIM-----PVLIITVCYGLMILRLksvrmlsgSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYV--- 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 296 sfilleIIKQGCEFENTVHKWIS--ITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15090   233 ------IIKALVTIPETTFQTVSwhFCIALGYTNSCLNPVLYAFLDENFK 276
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
77-345 3.16e-32

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 122.72  E-value: 3.16e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15155     6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNFnRHWPFGDSLCKISGTAFLTNIYG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQ 235
Cdd:cd15155    86 SMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLFSTTNVSNTSTTCFEGFSKSIWKTYLSKI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 236 HI---MVGLILPGIVILSCYCIIISKLSHSK-----GHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQgC 307
Cdd:cd15155   166 TIfieVVGFIIPLLLNLTCSSLVLRTLRKPAtlsqiGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIAN-C 244
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 308 EFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15155   245 GVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQKS 282
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
72-343 3.56e-32

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 122.52  E-value: 3.56e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL---LFVITLPFWAVdAVANWYFGNFLCKAVHVI 148
Cdd:cd15393     1 VLLSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIiigLFSIPFQFQAA-LLQRWVLPRFMCPFCPFV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSqRPRKLLAeKVVYVGVWIPALLLTIPDFIFANVSEADD------RYICDRF 222
Cdd:cd15393    80 QVLSVNVSVFTLTVIAVDRYRAVIHPLKA-RCSKKSA-KIIILIIWILALLVALPVALALRVEELTDktnngvKPFCLPV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSK-------------GHQKRKALKTTVILILAFFACWLPYY 289
Cdd:cd15393   158 GPSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKapgnaqdvrddeiLKNKKKVIKMLIIVVALFALCWLPLQ 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 290 IgISIDSFILLEIIKqgcefentvHKWISI----TEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15393   238 T-YNLLNEIKPEINK---------YKYINIiwfcSHWLAMSNSCYNPFIYGLYNEKFK 285
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
72-343 4.90e-32

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 122.17  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15162     1 VFLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHgnNWIFGEALCRLVTVAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRFYPNDL 227
Cdd:cd15162    81 YGNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFlpALDITTCHDVLPEQL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHI---MVGLILPGIVILSCYCIIISKLSHSK----GHQKRKALKTTVILILAFFACWLPyyigisidSFILL 300
Cdd:cd15162   161 LVGDWFYYFLslaIVGFLIPFILTASCYVATIRTLAALEdensEKKKKRAIKLAATVLAIFIICFAP--------SNLLL 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 301 EIIKQGCEFENTVHKWIS--ITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15162   233 LAHYSLISSSGTGHLYFAylLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
72-343 1.49e-31

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 120.67  E-value: 1.49e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAvdAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15920     1 VTLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRV--AYQNTAGPLSFCKIVGAFFYL 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFANVSEADDRYICDRFYPNDLWVVV 231
Cdd:cd15920    79 NMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIP-FLFESRNEGPCDNKCFHFRSKGLTAGG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHIMVGLILpGIVILSCYCIIISKL---SHSKGHQ-----KRKALKTTVILILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15920   158 INLTAVVIFYIL-SLLFLYFYAKISHKLykvSLGNAQQqikkaSKRAIIKTFIVLAIFIVCFVPYHIVRVPYVLAQIDVI 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KqGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15920   237 S-SLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
78-345 1.75e-31

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 120.19  E-value: 1.75e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15206     7 YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLlRNFIFGEVMCKLIPYFQAVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR--YICDRFYPNDlwvVVFQ 233
Cdd:cd15206    87 STFTLVAISLERYFAICHPLKSRVWQTLSHAYKVIAGIWLLSFLIMSPILVFSNLIPMSRPggHKCREVWPNE---IAEQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLIL---PGIVILSCYCIIISKLSHSkghqKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQgceFE 310
Cdd:cd15206   164 AWYVFLDLMLlviPGLVMSVAYGLISWTLLEA----KKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSAARY---VS 236
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 311 NTVhkwISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15206   237 STT---ISLIQLLAYISSCVNPITYCFMNKRFRQA 268
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
78-345 1.89e-31

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 120.96  E-value: 1.89e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPF-WAVDAVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15208     7 YILVFIVGLVGNVLVCFAVWRNHHMRTVTNYFIVNLSLADFLVIIIcLPAtLLVDVTETWFFGQVLCKIIPYLQTVSVSV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANVS-------EADDRYICDRFYPNDLW 228
Cdd:cd15208    87 SVLTLSCIALDRWYAICHPLMFKSTAK--RARVSILIIWIVSLLIMIPQAIVMECSrvvplanKTILLTVCDERWSDSIY 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKL-----------------SHSKG---------HQKRKALKTTVILILAFF 282
Cdd:cd15208   165 QKVYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgtssvvqrkwnKPRKSavaaeekqlRSRRKTAKMLIVVVIMFA 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 283 ACWLPYYIgisidsfilLEIIKQ--GCEFEN--TVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15208   245 ICYLPVHL---------LNILRYvfGLFTVDreTIYAWFLFSHWLVYANSAINPIIYNFMSGKFREE 302
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
72-343 2.03e-31

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 120.44  E-value: 2.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYT 150
Cdd:cd15089     1 IAITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKyLMETWPFGELLCKAVLSIDY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD-RYICDRFYPNDLW- 228
Cdd:cd15089    81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRDgAVVCMLQFPSPSWy 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 ------VVVFQFqhimvGLILPGIVILSCYCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISI 294
Cdd:cd15089   161 wdtvtkICVFIF-----AFVVPILVITVCYGLMILRLrsvrllsgSKEKDRNLRRITRMVLVVVAAFIICWTPIHIFVIV 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1127774881 295 dsFILLEIIKQGCEFENTVHKWIsiteALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15089   236 --WTLVDIDRRNPLVVAALHLCI----ALGYANSSLNPVLYAFLDENFK 278
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
72-343 3.70e-31

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 119.92  E-value: 3.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPF----WAVDAvaNWYFGNFLCKAVHV 147
Cdd:cd15339     1 VILPSFIGILCSTGLVGNILVLFTIIRSRK-KTVPDIYVCNLAVADLVHIIVMPFlihqWARGG--EWVFGSPLCTIITS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV-SEADDRYIC--DRFYP 224
Cdd:cd15339    78 LDTCNQFACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKViKFRDGLESCafNLTSP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 ND-LWVVVFQfqhIMVGLILPGIVILSCYCIII---------SKLSHSKGHQK-----RKALKTTVILILAFFACWLPYY 289
Cdd:cd15339   158 DDvLWYTLYQ---TITTFFFPLPLILICYILILcytwemyrkNKKAGRYNTSIprqrvMRLTKMVLVLVGVFLVSAAPYH 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 290 IgisidsFILLEIIKQGCEFENTVHKWISIteALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15339   235 V------IQLVNLSVSQPTLAFYVSYYLSI--CLSYASSSINPFLYILLSGNFR 280
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
76-344 6.19e-31

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 119.39  E-value: 6.19e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL---FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15392     5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDILmavFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSqRPRKLLAEKVVYVgVWIPALLLTIPDFIFANV----SEADDRYICDRFYPNDLW 228
Cdd:cd15392    85 VFVSAFTLVAISIDRYVAIMWPLRP-RMTKRQALLLIAV-IWIFALATALPIAITSRLfedsNASCGQYICTESWPSDTN 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKL---------SHSKGHQ----KRKALKTTVILILAFFACWLPYYIGIsid 295
Cdd:cd15392   163 RYIYSLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgeaENNRDQRmaesKRKLVKMMITVVAIFALCWLPLNILN--- 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1127774881 296 sfILLEIIKQGCEFENTVHKWISItEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15392   240 --LVGDHDESIYSWPYIPYLWLAA-HWLAMSHCCYNPFIYCWMNAKFRN 285
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
72-343 1.17e-30

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 118.55  E-value: 1.17e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCKAVHVIY 149
Cdd:cd15390     1 VLWSIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLisAFNTVFNFTYLLYNDWPFGLFYCKFSNFVA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANV-----SEADDRYICDRFYP 224
Cdd:cd15390    81 ITTVAASVFTLMAISIDRYIAIVHPLRPRLSRR--TTKIAIAVIWLASFLLALPQLLYSTTetyyyYTGSERTVCFIAWP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLI---LPGIVILSCYCIIISKLSHSKG------HQ------KRKALKTTVILILAFFACWLPYY 289
Cdd:cd15390   159 DGPNSLQDFVYNIVLFVVtyfLPLIIMAVAYTRVGVELWGSKTigentpRQlesvraKRKVVKMMIVVVVIFAICWLPYH 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 290 IgisidSFILLEIIKQGCEFENTVHKWISITeALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15390   239 L-----YFILTYLYPDINSWKYIQQIYLAIY-WLAMSNSMYNPIIYCWMNKRFR 286
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
72-346 1.20e-30

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 118.32  E-value: 1.20e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF--WAVDAVANWYFGNFLCKAVHVIY 149
Cdd:cd15373     1 ILLPVSYGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLlvYYYADENDWPFSEALCKIVRFLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15373    81 YTNLYCSILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVTTSDKGGNITCHDTSSPELFD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLI--LPGIVILSCYCIIISKL------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIdsFILLE 301
Cdd:cd15373   161 QFVVYSSVMLVLLfcVPFVVILVCYALMVRKLlkpsagTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTL--YYSFR 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 302 IIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15373   239 SMDLSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFRSNL 283
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
72-343 8.68e-30

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 116.06  E-value: 8.68e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLR---SMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVH 146
Cdd:cd15338     1 VIMPSVFGVICFLGIIGNSIVIYTIVKKSKFRcqqTVPDIFIFNLSIVDLLFLLGMPFLIHQLLGNgvWHFGETMCTLIT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 147 VIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI-CDRFYPN 225
Cdd:cd15338    81 ALDTNSQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLMPLPDGSVgCALLLPN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 ---DL-WVVVFQFqhiMVGLILPGIVILSCYCIIISKLS--------HSKGHQKRKALKTTVILILAFFACWLPYYIgis 293
Cdd:cd15338   161 petDTyWFTLYQF---FLAFALPLVVICVVYFKILQNMAstvaplpqRSLRVRTKKVTRMAVAICLAFFICWAPFYI--- 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 294 idsfilLEIIKQGCEFEN-TVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15338   235 ------LQLAHLSIDRPSlAFLYAYNVAISMGYANSCINPFLYIMLSETFK 279
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
72-337 9.60e-30

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 116.06  E-value: 9.60e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVD-AVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15118     1 VATICLHGIVSTLGIVENLLILWVVGFRLR-RTVISIWILNLALSDLLATLSLPFFTYYlASGHtWELGTTFCRIHSSIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-ADDRYIC----DRFYP 224
Cdd:cd15118    80 FLNMFVSGFLLAAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIPYFVFRDVIErKDGRKLCyynfALFSP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 N--------DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisids 296
Cdd:cd15118   160 SpdnnhpicKQRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHI------ 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 297 FILLEIIKQGC-EFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15118   234 FSIIEVMAHNQhSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
73-344 1.07e-29

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 116.21  E-value: 1.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWA-VDAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15927     2 VVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTcVPFTStIYTLDSWPFGEFLCKLSEFLKD 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV--SEADDR---YICDRfYPN 225
Cdd:cd15927    82 TSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVvtFTLTDNqtiQICYP-YPQ 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLI---LPGIVILSCYCIIISKL---------SHSKGHQK-----RKALKTTVILILAFFACWLPY 288
Cdd:cd15927   161 ELGPNYPKIMVLLRFLVyylIPLLIIGVFYVLMARHLirstrnigsGQNQAAQRqiearKKVAKTVLAFVVLFAVCWLPR 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 289 YIgisidSFILLEIIKQGCEFENTVHKWISITE-ALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15927   241 HV-----FMLWFHFAPNGLVDYNAFWHVLKIVGfCLSFINSCVNPVALYLLSGSFRR 292
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
77-344 2.49e-29

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 115.08  E-value: 2.49e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF------VITLPFWAVDAvanWYFGNFLCKAVHVIYT 150
Cdd:cd14997     6 VYGVIFVVGVLGNVLVGIVVWKNKDMRTPTNIFLVNLSVADLLVllvcmpVALVETWAREP---WLLGEFMCKLVPFVEL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRP-RKLLAEKVVYVgVWIPALLLTIPDFIFANVSEADDR-----YICdRFYP 224
Cdd:cd14997    83 TVAHASVLTILAISFERYYAICHPLQAKYVcTKRRALVIIAL-IWLLALLTSSPVLFITEFKEEDFNdgtpvAVC-RTPA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL-------SHSKGHQKRKALKTT-------VILILAFFACWLPYYI 290
Cdd:cd14997   161 DTFWKVAYILSTIVVFFVVPLAILSGLYSVICRRLvghpaleSRRADAANRHTLRSRrqvvymlITVVVLFFVCLLPFRV 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 291 gisidsFILLEIIKQGCEFEN----TVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd14997   241 ------VTLWIIFAPDEDLQAlgleGYLNLLVFCRVMVYLNSALNPILYNLMSTKFRS 292
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
78-343 3.19e-29

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 114.48  E-value: 3.19e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF-WAVDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15154     7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLrIYYYANHYWPFGNFLCQFSGSIFQMNMYGS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR----YICDRFYPNDLWVVVF 232
Cdd:cd15154    87 CLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHgekvYRCFESFSDNDWKGLL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHI--MVGLILPGIVILSCYCIIISKLSHS---KGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGC 307
Cdd:cd15154   167 PLVVLaeILGFLLPLAAVLYCSCRIFVELCRTqepQQGRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRANLVEDTW 246
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 308 EFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15154   247 NIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFR 282
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-343 3.39e-29

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 114.46  E-value: 3.39e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd14999     1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIPFYVSTYFLKkWYFGDVGCRLLFSLDFL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIFANVSEADD-----RYIC------- 219
Cdd:cd14999    81 TMHASIFTLTVMSTERYLAVVKPLDTVKRSKSYR-KLLAGVIWLLSLLLTLPMAIMIRLVTVEDksggsKRIClptwsee 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 -DRFYPNDLWVVVFqfqhimvglILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYY 289
Cdd:cd14999   160 sYKVYLTLLFSTSI---------VIPGLVIGYLYIRLARKYwlsqaaasnSSRKRLPKQKVLKMIFTIVLVFWACFLPFW 230
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 290 IgisidsFILLEIIKQGCEFENTVHKWISI-TEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14999   231 I------WQLLYLYSPSLSLSPRTTTYVNYlLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
72-343 4.80e-29

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 114.08  E-value: 4.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTD--KYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHV 147
Cdd:cd15147     1 TLFPIVYSIIFVLGLIANCYVLWVFARLYPSKKLNEikIFMVNLTIADLLFLITLPFWIVyyHNEGNWILPKFLCNVAGC 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVH----ATNSQRPRKLlaekVVYVGVWIPALLLTIPDFIF--ANVSEADDRYI--C 219
Cdd:cd15147    81 LFFINTYCSVAFLGVISYNRYQAVTRpiktAQSTTRKRGI----IISVAIWVIIVASASYFLFMdsTNTVKIDSGNFtrC 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPNDLWVVVFQFQHIMVGLI-LPGIVILSCYCIIISKL------SHSKGHQKRKALKTTVILILAFFACWLPYYIGI 292
Cdd:cd15147   157 FEGYEKDNSKPVLIIHFIIIGLFfLVFLLILVCNLVIARTLlsqpvqGQRNAGVKRRALWMVCTVLAVFVICFVPHHVVQ 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 293 SIDSFILLEIIKQ-GCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15147   237 GPWTLAVLQQWRYwDCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFR 288
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
73-336 6.29e-29

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 113.64  E-value: 6.29e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDK-YRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15376     2 FLWPILGVEFLVAVLGNGLALWLFVTRERRPWHTGVvFSFNLAVSDLLYALSLPLLAAYYYPpkNWRFGEAACKLERFLF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVH---ATNSQRPRKllaEKVVYVGVWIPALLLTIPDFIFANV-SEADDRYICDRFYPN 225
Cdd:cd15376    82 TCNLYGSIFFITCISLNRYLGIVHpffTRSHVRPKH---AKLVSLAVWLLVAALSAPVLSFSHLeVERHNKTECLGTAVD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIM--VGLILPGIVILSCYCIIISKLSHSKG---HQKRKaLKTTVILILAFFAC-WLPYYIGISIDSFIL 299
Cdd:cd15376   159 SRLPTYLPYSLFLavVGCGLPFLLTLASYLAIVWAVLRSPGittLEKRK-VAALVAVVVALYAVsFVPYHILRNLNLYRR 237
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 300 LEIIKqgCEFENTVHKWISITEALAFFHCCLNPILYA 336
Cdd:cd15376   238 LQWLK--AAASLRIYFAYQVTKGLVTLNMCIHPLLYM 272
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-343 7.00e-29

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 113.85  E-value: 7.00e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLP---FWAVDAvANWYFGNFLCKAVHVIY 149
Cdd:cd15377     2 YLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPaliFYYFNK-TDWIFGDAMCKLQRFIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI------CDRFY 223
Cdd:cd15377    81 HVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVRKNKTItcydttSDEYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNdlwVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQ--------KRKALKTTVILILAFFACWLPYYIGISID 295
Cdd:cd15377   161 RS---YFIYSMCTTVAMFCVPFILILGCYGLIVRALIYKDMKYteennaplRRKSIYLVIIVLTVFAVSYLPFHVMKTLN 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1127774881 296 SFILLEI-IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15377   238 LRARLDFqTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFR 286
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
76-338 9.50e-29

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 113.26  E-value: 9.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFviTLPFWAVDAVAN----WYFGNFLCKAVHVIYTV 151
Cdd:cd15195     5 LVTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMV--TFFNMPMDAVWNytveWLAGDLMCRVMMFLKQF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATN-SQRPRKLlaeKVVYVGVWIPALLLTIPD-FIFANVS---EADDRYICDRFYPND 226
Cdd:cd15195    83 GMYLSSFMLVVIALDRVFAILSPLSaNQARKRV---KIMLTVAWVLSALCSIPQsFIFSVLRkmpEQPGFHQCVDFGSAP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ---LWVVVFQFQHIMVGLIlPGIVILSCYCIIISKL-------------------SHSKGHQKRKALKTTVILILAFFAC 284
Cdd:cd15195   160 tkkQERLYYFFTMILSFVI-PLIITVTCYLLILFEIskmakrardtpisnrrrsrTNSLERARMRTLRMTALIVLTFIVC 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 285 WLPYYIGISIDSFILLEIIKqgcefentVHKWIS-ITEALAFFHCCLNPILYAFL 338
Cdd:cd15195   239 WGPYYVLGLWYWFDKESIKN--------LPPALShIMFLLGYLNPCLHPIIYGVF 285
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
73-345 1.89e-28

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 112.48  E-value: 1.89e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYT 150
Cdd:cd15967     2 FLPPVYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGrkWIFGQVFCKITRFCFN 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSeaDDRYIC----DRFYPND 226
Cdd:cd15967    82 LNLYGSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKTN--SNGTKCfdttFNDYLES 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LwvVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQ---KRKALKTTVILILAFFACWLPYYIGISIDSFI-LLEI 302
Cdd:cd15967   160 Y--LTYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDkglKQRCLKLVIILIVLFSVCYIPYHVFRNLNLLSrILQK 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15967   238 QGSCTQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSEDILSR 280
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
72-337 3.82e-28

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 111.39  E-value: 3.82e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWA--VDAVANWYFGNFLCKAVHVIY 149
Cdd:cd15367     1 TLFPVVYILVLVVGLPANCLSLYYGYLQIKAKNELGIYLCNLTVADLLYIFSLPFWLqyVLQHDNWTYSELLCKICGILL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE-ADDRYICDRFYPNDLW 228
Cdd:cd15367    81 YENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCVFFFLHGEISKdKENHSVCFEHYPIKAW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKR-----KALKTTVILIlaFFACWLPYYIGISIDSfilleII 303
Cdd:cd15367   161 EHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSqkiqiKRLVLSTVVI--FLVCFGPYHILLLVRS-----VF 233
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15367   234 ERDCNFAEGIFNYYHFSLLLTSFNCVADPVLYCF 267
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
72-290 9.10e-28

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 110.44  E-value: 9.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFwAVD--AVAN--WYFGNFLCKAVH 146
Cdd:cd15204     1 IVLGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVaVFCLPF-EMDyyVVRQrsWTHGDVLCAVVN 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 147 VIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAekVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRFYP 224
Cdd:cd15204    80 YLRTVSLYVSTNALLVIAIDRYLVIVHPLKPRMKRRTAC--VVIALVWVVSLLLAIPSAVYSKTTPyaNQGKIFCGQIWP 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 ND---------LWVVVFQFqhimvglILPGIVILSCYCIIISKLSHSK--GHQ-------KRKALKTTVILIL---AFFA 283
Cdd:cd15204   158 VDqqayykayyLFLFVLEF-------VLPVLIMTLCYLRIVRKVWFRRvpGQQteqirrrLRRRRRKVRLLVViltAFVL 230

                  ....*..
gi 1127774881 284 CWLPYYI 290
Cdd:cd15204   231 CWAPYYG 237
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
79-337 9.76e-28

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 110.02  E-value: 9.76e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI--TLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15196     8 ATILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVALfnVLPQLIWDITYRFYGGDLLCRLVKYLQVVGMYAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVgVWIPALLLTIPD-FIFANVSEADDRYIC-DRFYPN------DLW 228
Cdd:cd15196    88 SYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPQlFIFSYQEVGSGVYDCwATFEPPwglrayITW 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFqhimvglILPGIVILSCY---CIIISKlshskghQKRKALKTTVILILAFFACWLPyyigisidsFILLEIIKQ 305
Cdd:cd15196   167 FTVAVF-------VVPLIILAFCYgriCYVVWR-------AKIKTVKLTLVVVACYIVCWTP---------FFVVQMWAA 223
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 306 GCEFENTVHKWISITEALAFFHCCLNPILY-AF 337
Cdd:cd15196   224 WDPTAPIEGPAFVIIMLLASLNSCTNPWIYlAF 256
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
73-343 1.25e-27

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 109.92  E-value: 1.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSI-IFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd14989     1 FLSCLYTIfLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNLNEKYYDIAVLCTFMSLFLQI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVvv 231
Cdd:cd14989    81 NMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATLLPFTAVQAQHTGEVHFCFADVREIQWL-- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 fqfqHIMVGLILPGIVILSCYCIIISKLSHSKGH-----QKRKALKTTVILILAFFACWLPYYIGISIDsfILLEIIKQG 306
Cdd:cd14989   159 ----EVTLGFIIPFSIIGLCYSLIVRVLVRAQKHrrlrpRRQKALRMILVVVLVFFICWLPENVFISIQ--LLQGTQEPS 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 307 CEFENTVHKWISITEAL----AFFHCCLNPILYAFLGAKFK 343
Cdd:cd14989   233 ESYDESFRHNHPLTGHIvnlaAFSNSCLNPLIYSFLGETFR 273
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
72-343 1.68e-27

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 109.90  E-value: 1.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15202     1 VLLIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAVNNtWIFGLFMCHFSNFAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATnsqRPR-KLLAEKVVYVGVWIPALLLTIPDFIFANV-----SEADDRYICDRFY 223
Cdd:cd15202    81 YCSVHVSAYTLTAIAVDRYQAIMHPL---KPRiSKTKAKFIIAVIWTLALAFALPHAICSKLetfkySEDIVRSLCLEDW 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNDLWVVVFQFQHIMVGL--ILPGIVILSCYCIIISKLSHSK-------------GHQKRKALKTTVILILAFFACWLPY 288
Cdd:cd15202   158 PERADLFWKYYDLALFILqyFLPLLVISFAYARVGIKLWASNmpgdatteryfalRRKKKKVIKMLMVVVVLFALCWLPF 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1127774881 289 YIgisidSFILLEIikqgceFENTVHKWISI----TEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15202   238 NI-----YVLLLSS------KPDYLIKTINAvyfaFHWLAMSSTCYNPFIYCWLNERFR 285
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
72-337 2.06e-27

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 109.50  E-value: 2.06e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWaVDAVA---NWYFGNFLCKAVHVI 148
Cdd:cd15366     1 LFPPTLYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLW-IDYFLhrdNWIHGPESCKLFGFI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEadDRY---ICDRFYPN 225
Cdd:cd15366    80 FYTNIYISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFHDELFR--DRYnhtFCFEKYPM 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS---KGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLei 302
Cdd:cd15366   158 EDWVAWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNvstEQQEKAKIKRLALSLIAIVLLCFAPYHVLLLSRSVVYL-- 235
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 303 IKQG-CEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15366   236 GKPCdCGFEERVFTAYHVSLALTSLNCVADPILYCL 271
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
73-344 2.49e-27

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 109.42  E-value: 2.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD-AVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15378     2 YLPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSySNGQWLFGDFLCKSNRYLLHA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYP--NDLWV 229
Cdd:cd15378    82 NLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNLKDNVTKCKDYASsgDATNS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPgIVILSCYCIIISKLSHSKGHQK------RKALKTTVILILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15378   162 LIYSLFLTVTGFLIP-LCVMCFFYYKIALFLKNRNRQLanatsfEKPLTLVILAVVIFSVLFTPYHVMRNVRIASRLDSI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15378   241 GVSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFRE 281
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
76-346 2.49e-27

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 109.35  E-value: 2.49e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15165     5 VVYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHSSKKQWPLGRTLCSFLESLYFVNMYG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQR---PRKLLaekVVYVGVWIPALLLTIPDFIFANvsEADDRYICDRFYPNDLWVVVF 232
Cdd:cd15165    85 SILIIVCISVDRYIAIRHPFLAKRlrsPRKAA---IVCLTIWVFVWAGSIPIYSFHD--KPTNNTRCFHGFSNKTWSKKV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILIL-----AFFACWLPYYIGISIDSFILLEIIKQgC 307
Cdd:cd15165   160 IVVVEEFGFLIPMAVMVFCSVQIIRTLLDMRRPEQPKVKQNKSVKIVlsnlvVFLVCFTPYHLGIFLQFLVKNDIIND-C 238
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 308 EFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15165   239 STKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFRESA 277
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
72-343 5.13e-27

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 108.32  E-value: 5.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIY 149
Cdd:cd15368     1 VILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIqrNHWIFGKPLCNVVTVLF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRF------- 222
Cdd:cd15368    81 YANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPLERTDLTYYVKELNITTCFdvlkwtm 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH----QKRKALKTTVILILAFFACWLPyyigisiDSFI 298
Cdd:cd15368   161 LPNIAAWAAFLFTLFILLFLIPFIITVYCYVLIILKLVQTSERygreQKRRAIYLALIVLLVFITCFAP-------NNFI 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 LLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15368   234 LLAHMVSRLFYGKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFR 278
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
73-346 5.31e-27

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 108.30  E-value: 5.31e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQ-KKLRSMTdkYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15372     2 LVPSLYTLVFLVGLPANGLALWVLATQvKRLPSTI--FLINLAVADLLLILVLPFKISYHFLgnNWPFGEGLCRVVTAFF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFANVS---EADDRYICDRFYPND 226
Cdd:cd15372    80 YGNMYCSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLP-LTLQRQSyplERLNITLCHDVLPLD 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQH---IMVGLILPGIVILSCYCIIISKLSHSkGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEII 303
Cdd:cd15372   159 EQDTYLFYYFaclAVLGFLLPLVVILFCYGSVLHTLLRS-GQRYGHAMKLTVLVLVSFVLCFTPSNL------LLLLHYS 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15372   232 DPTLDDGGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFRDKV 274
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
72-343 5.51e-27

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 108.37  E-value: 5.51e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKL-RSMTDKYRLHLSVADLLFVI-TLPFWA-VDAVANWYFGNFLCKAVHVI 148
Cdd:cd15097     1 VIVPVVFSLIFLLGTVGNSLVLAVLLRSGQSgHNTTNLFILNLSVADLCFILfCVPFQAtIYSLEGWVFGSFLCKAVHFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYpNDLW 228
Cdd:cd15097    81 IYLTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYANSTVCMPGW-EEAR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIISKL----------SHSKgHQKRKALKTTVILILAFFACWLPYYIgisidsfI 298
Cdd:cd15097   160 RKAMDTCTFAFGYLIPVLVVSLSYTRTIKYLwtavdpleamSESK-RAKRKVTKMIIIVTALFCLCWLPHHV-------V 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 LLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15097   232 ILCYLYGDFPFNQATYAFRLLSHCMAYANSCLNPIVYALVSKHFR 276
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
75-344 7.25e-27

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 107.94  E-value: 7.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWaVDAV---ANWYFGNFLCKAVHVIYTV 151
Cdd:cd15365     4 PFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLW-IDYLwngDNWTLSGFVCIFSAFLLYT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWI-----PALLLTIPDfifaNVSEADDRYICDRFYPND 226
Cdd:cd15365    83 NFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLleicfNAVILTWED----SFHESSSHTLCYDKFPLE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG---HQKRKALKTTVILILAFFACWLPYYIgisidsFILLEII 303
Cdd:cd15365   159 DWQARLNLFRICLGYLLPLLIILFCYWKIYQAVRSNQAtedQEKKKIFKLLLLITVTFVICFTPYHV------VLLIRSI 232
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 304 KQGCEFENTvhKWI----SITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15365   233 VEPCDCRNA--KWLytlyKITVALTSLNCIADPFLYCFVTESGRA 275
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
77-343 8.64e-27

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 108.21  E-value: 8.64e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFwavDAVANWY-----FGNFLCKAVHVIYT 150
Cdd:cd14979     6 IYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLiLLVGLPV---ELYNFWWqypwaFGDGGCKLYYFLFE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHA----TNSQRPRKllaeKVVYVGVWIPALLLTIPDFI--------FANVSEADDRYI 218
Cdd:cd14979    83 ACTYATVLTIVALSVERYVAICHPlkakTLVTKRRV----KRFILAIWLVSILCAIPILFlmgiqylnGPLPGPVPDSAV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 219 CDRFYPNDLWVVVFQFQhIMVGLILPGIVILSCYCIIISKLSHSKGHQK--------------RKALKTTVILIL----- 279
Cdd:cd14979   159 CTLVVDRSTFKYVFQVS-TFIFFVLPMFVISILYFRIGVKLRSMRNIKKgtraqgtrnvelslSQQARRQVVKMLgavvi 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 280 AFFACWLPYYigisIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14979   238 AFFVCWLPFH----AQRLMFSYASKEDTFLFDFYQYLYPISGILFYLSSAINPILYNLMSSRFR 297
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
72-290 1.29e-26

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 107.65  E-value: 1.29e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15379     1 VLLPLVYSVVFLLGLPLNAVVIGQIWATRQALSRTTIYMLNLATADLLYVCSLPLLIYNYTQKdyWPFGDFTCRLVRFQF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRK-LLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW 228
Cdd:cd15379    81 YTNLHGSILFLTCISVQRYLGICHPLASWHKKKgKKLTWLVCGAVWLVVIAQCLPTFVFASTGTQRNRTVCYDLSPPARS 160
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 229 VVVFQFQHIM--VGLILPGIVILSCYCIIISKLSHSKG--------HQKR-KALKTTVILILAFFACWLPYYI 290
Cdd:cd15379   161 TAYFPYGITLtrTGFLLPFAARLACYCSMATILCRVVIavavvaapGEKRgKAARMIIVVAAVFLISFLPFHY 233
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
76-345 1.77e-26

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 106.91  E-value: 1.77e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd14969     5 VYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNLSGrWSFGDPGCVIYGFAVTFLG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVyVGVWIPALLLTIPDFIFAN--VSEAdDRYICD-RFYPNDLWVV 230
Cdd:cd14969    85 LVSISTLAALAFERYLVIVRPLKAFRLSKRRALILI-AFIWLYGLFWALPPLFGWSsyVPEG-GGTSCSvDWYSKDPNSL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQK---------------RKALKTTVILILAFFACWLPYYIgisid 295
Cdd:cd14969   163 SYIVSLFVFCFFLPLAIIIFCYYKIYRTLRKMSKRAArrknsaitkrtkkaeKKVAKMVLVMIVAFLIAWTPYAV----- 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 296 sFILLEIIKQgcefENTVHKWIS-ITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14969   238 -VSLYVSFGG----ESTIPPLLAtIPALFAKSSTIYNPIIYVFMNKQFRRA 283
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
72-342 4.51e-26

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 106.23  E-value: 4.51e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVI- 148
Cdd:cd15048     1 IVLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLTGkWPFGKVFCKAWLVVd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVnLYSSVLILAFISLDRYLAIVHATNSQR---PRKLLAEKVVyvgVWIPALLLTIPDFIFANV---SEADDRYICDRF 222
Cdd:cd15048    81 YTL-CTASALTIVLISLDRYLSVTKAVKYRAkqtKRRTVLLMAL---VWILAFLLYGPAIIGWDLwtgYSIVPTGDCEVE 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLwvvVFQFQHIMVGLILPGIVILSCYCII---ISKLSHSKGHQK-------------------------RKALKTT 274
Cdd:cd15048   157 FFDHF---YFTFITSVLEFFIPFISVSFFNLLIylnIRKRSRRRPLRSvpilpasqnpsrarsqreqvklrrdRKAAKSL 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 275 VILILAFFACWLPYYIGISIDSFilleiikqgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15048   234 AILVLVFLICWAPYTILTIIRSF---------CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRF 292
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
77-343 4.64e-26

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 106.26  E-value: 4.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPF-----WAVDAvanWYFGNFLCKAVHVIYT 150
Cdd:cd15134     6 IYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLLLLILgLPFelytiWQQYP---WVFGEVFCKLRAFLSE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP-----DFIFANVSEAD-----DRYICD 220
Cdd:cd15134    83 MSSYASVLTITAFSVERYLAICHPLRSHTMSKLSRAIRIIIAIWIIAFVCALPfaiqtRIVYLEYPPTSgealeESAFCA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 221 RFYPNDLWVVVFQFQHImVGLILPGIVILSCYCIIISKLSHS--------------KGHQKRKA-LKTTVILILAFFACW 285
Cdd:cd15134   163 MLNEIPPITPVFQLSTF-LFFIIPMIAIIVLYVLIGLQLRRStllrrgqrsvsggrRSSQSRRTvLRMLVAVVVAFFICW 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1127774881 286 LPYYIGISIDSFilleiIKQGCEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15134   242 APFHAQRLLTVY-----AKNMTPPYLFINRILfYISGVLYYVSSTVNPILYNVMSAKYR 295
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
77-343 6.59e-26

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 105.23  E-value: 6.59e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15923     6 IYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRRESAGLQKLCNFVLSLYYINMYVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVH---ATNSQRPRKLLaekVVYVGVWIPALLLTIPDFIFANvseADDRYICDRfYPNDLWVVVFQ 233
Cdd:cd15923    86 IFTITAISVDRYVAIRYplrARELRSPRKAA---VVCAVIWVLVVTISIPYFLLDS---SNEKTMCFQ-RTKQTESLKVF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIISKLSHSKGH-QKRKALKTTVILILA----FFACWLPYYIGISIDSFILLEIikqGCE 308
Cdd:cd15923   159 LLLEIFGFLLPLIIMTFCSARVIHTLQKRLDDvGSRSETKQCIRVIMAnlivFIVCFLPVHVGFFVKFIVGKSY---SCD 235
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15923   236 SKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
76-345 1.12e-25

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 104.83  E-value: 1.12e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI--TLPFWAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15012     4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfcVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADD--------RYICDRFYPN 225
Cdd:cd15012    84 TASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVtqdgqeeeICVLDREMFN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFqhiMVGLILPGIVILSCYCIIISKLSHS-KGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIK 304
Cdd:cd15012   164 SKLYDTINF---IVWYLIPLLIMTVLYSKISIVLWKSsSIEARRKVVRLLVAVVVSFALCNLPYHA------RKMWQYWS 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 305 QGCEFENTVHKWIS-ITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15012   235 EPYRCDSNWNALLTpLTFLVLYFNSAVNPLLYAFLSKRFRQS 276
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
72-342 3.78e-25

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 103.33  E-value: 3.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTdKYRLHLSVADLLFVITLPFWAVD--AVANWYFGNFLCKAVHVIY 149
Cdd:cd15969     1 IVFPVLYLIIFIGSILLNGLAVWIFFHIRNKTSFI-FYLKNIVIADLLMTLTFPFKIIQdsGLGPWNFNFFLCRYTSVLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR-YICDRFYPN--D 226
Cdd:cd15969    80 YASMYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNIILTNGQPTEDNiHDCSKLKSPlgV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPgIVILSCYcIIISKLSHSKGHQ-------KRKALKTTVILILAFFACWLPYYIGISIDSFIL 299
Cdd:cd15969   160 KWHTAVSYINICIFVAVL-VILIVCY-ISISRYIYKSSKQfissssrTRKHNQSIRVVVAVFFVCFLPYHLCRIPFTFSQ 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 300 LEIIKQgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15969   238 LDKILD-CTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSF 279
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
72-337 4.32e-25

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 102.94  E-value: 4.32e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15364     1 IFLVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNhkWPWGSLACKITGYIF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANvSEADDRYICDRFYPNDLWV 229
Cdd:cd15364    81 FCNIYISILLLCCISIDRFVAVVYALESRGRRRQRIAAFISFLIFIVVGLVHSPVFIMRE-GQTEGSHTCFETLQMDTQV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG---HQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQG 306
Cdd:cd15364   160 AGFYYARFCIGFAIPLAILIFTNYRIFRSIQTSTSltpHQKAKVKYLAIAVIVIFLICFAPYHLVLLVRAIAFSLYPNGM 239
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15364   240 CGFEERIYTPSVIFLCLSTVNSVADPIIYVL 270
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
77-345 4.69e-25

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 103.02  E-value: 4.69e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15055     7 LSSISLLT-VLGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVgLLVMPFSMIRSIETcWYFGDTFCKLHSSLDYILTS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATN-SQRPRKLLAEKVVYVGvWIPALLLTIPDFIFANVSEADDRYI-CDR---FYPNDLWV 229
Cdd:cd15055    86 ASIFNLVLIAIDRYVAVCDPLLyPTKITIRRVKICICLC-WFVSALYSSVLLYDNLNQPGLIRYNsCYGecvVVVNFIWG 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVfqfqHIMVGLILPGIVILSCYCII-----------------ISKLSHSKGHQK---RKALKTTVILILAFFACWLPYY 289
Cdd:cd15055   165 VV----DLVLTFILPCTVMIVLYMRIfvvarsqarairshtaqVSLEGSSKKVSKkseRKAAKTLGIVVGVFLLCWLPYY 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 290 IGISIDSFILLEIIkqgcEFENTVhkWisiteaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15055   241 IVSLVDPYISTPSS----VFDVLI--W------LGYFNSCLNPLIYALFYPWFRKA 284
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
76-337 5.18e-25

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 103.16  E-value: 5.18e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNG--LVILVMGYQKKlRSMTDKYRLHLSVADLLFV-ITLPF---WAVdAVAnWYFGNFLCKAVHVIY 149
Cdd:cd15382     5 IVYSVLFLIAAVGNLtvLLILLRNRRRK-RSRVNILLMHLAIADLLVTfIMMPLeigWAA-TVA-WLAGDFLCRLMLFFR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPD-FIF--ANVSEADDRYICDRF--YP 224
Cdd:cd15382    82 AFGLYLSSFVLVCISLDRYFAILKPLRLSDARR--RGRIMLAVAWVISFLCSIPQsFIFhvESHPCVTWFSQCVTFnfFP 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSK------------------------GHQKRKALKTTVILILA 280
Cdd:cd15382   160 SHDHELAYNIFNMITMYALPLIIIVFCYSLILCEISRKSkekkedvseksssvrlrrssvgllERARSRTLKMTIVIVLV 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 281 FFACWLPYYIgISIDSFILLEIIKQgceFENTVHKWISIteaLAFFHCCLNPILYAF 337
Cdd:cd15382   240 FIICWTPYFI-MSLWYWFDRESASK---VDPRIQKGLFL---FAVSNSCMNPIVYGY 289
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
72-343 2.06e-24

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 101.35  E-value: 2.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPtIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDA--VANWYFGNFLCKAVHVI 148
Cdd:cd15394     2 LIIP-LYSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAfePRGWVFGRFMCYFVFLM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAekVVYVGVWIPALLLTIPDFIFANVSE--ADDRYICDRF---- 222
Cdd:cd15394    81 QPVTVYVSVFTLTAIAVDRYYVTVYPLRRRISRRTCA--YIVAAIWLLSCGLALPAAAHTYYVEfkGLDFSICEEFwfgq 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 ------YPNDLWVVVFqfqhimvglILPGIVILSCYCIIISKLSHS-------------KGHQKRKALKTTVILILAFFA 283
Cdd:cd15394   159 ekqrlaYACSTLLITY---------VLPLLAISLSYLRISVKLRNRvvpgsmtqsqaewDRARRRKTFRLLVVVVVAFAI 229
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 284 CWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEAlaffhcCLNPILYAFLGAKFK 343
Cdd:cd15394   230 CWLPLHIFNVIRDIDIDLIDKQYFNLIQLLCHWLAMSSA------CYNPFLYAWLHDSFR 283
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
73-343 2.59e-24

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 101.03  E-value: 2.59e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGlVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd15371     2 LIPAVYIIVVVLGVPSNA-IILWMLFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNgnNWVFGETMCRIITITFY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHA-TNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIFAN---VSEAdDRYICDRFYPND 226
Cdd:cd15371    81 GNMYCSILLLTCISINRYLAIVHPfIYRSLPKKTYA-VLICALVWTIVFLYMLPFFILKQtyyLKEL-NITTCHDVLPEC 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQH----IMVGLILPGIVILSCYCIIISKLsHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEI 302
Cdd:cd15371   159 EQNSNFQFYYfismAVFGFLIPLVITIFCYISIIRTL-NAYEHKWFWYVKITALVLIIFTICFAPSNV------ILIIHH 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYaFLGAKFK 343
Cdd:cd15371   232 FNYYYFNNDNLYSIYLIALCLGSLNSCLDPFLY-FLMSKWR 271
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
72-345 2.71e-24

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 101.02  E-value: 2.71e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIY 149
Cdd:cd15199     1 IAYASLLILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNgnRWSLGGGTCKALLFML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIfanVSEADDRYICDRFYPND--- 226
Cdd:cd15199    81 SLSRGVSIAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIPTLL---ASQPKNFTECNSFSPKDded 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ----LWVVVFQFQhimvgLILPGIVILSCYCIIISKL-------SHSKGHQKRKALKTTVILILAFfaCWLPYYIGisid 295
Cdd:cd15199   158 fsdtWQEAVFFLQ-----FLLPFGLIVFCTVRIIRRLkkrlrdvGKQPKLQRAMALVTSVVVVFGF--CFLPCFLA---- 226
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 296 sFILLEI--IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15199   227 -RVLMLIfqNKESCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRSS 277
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
73-345 2.97e-24

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 100.13  E-value: 2.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVD-AVANWYFGNFLCKaVHVIYT 150
Cdd:cd15061     1 ILISFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVgVLVLPLAIIRqLLGYWPLGSHLCD-FWISLD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNL-YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICdrFYPNDLWV 229
Cdd:cd15061    80 VLLcTASILNLCCISLDRYFAITYPLKYRTKRSRRLAITMILAVWVISLLITSPPLVGPSWHGRRGLGSC--YYTYDKGY 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQfqhIMVGLILPGIVILSCYCIIISKLshskgHQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikqGCEF 309
Cdd:cd15061   158 RIYS---SMGSFFLPLLLMLFVYLRIFRVI-----AKERKTAKTLAIVVGCFIVCWLPFFIMYLIEPFC-------DCQF 222
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 310 ENTVHKWISiteALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15061   223 SEALSTAFT---WLGYFNSVINPFIYAFYNKDFRRA 255
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
72-345 3.14e-24

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 100.94  E-value: 3.14e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIY 149
Cdd:cd15922     1 PAIPVFLSLVFLGGFLLNSFSLWIFWFRIKQWSSGTILQFNLALSDAIITPAAPLLIAYFSlgSHWPFGQFLCQLKVFLL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15922    81 STHMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLKTSVIDGKTKCLSIHQSELSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMV--GLILPGIVILSCYCII---ISKLS--HSKGHQ-KRKALKTTVILILAFFACWLPYYIGISIdSFILLE 301
Cdd:cd15922   161 LYFVWNFVLLilGFLLPFGVSLTCYALLgasIAKMNsnNARGRAmKAKSLQMIGISLVIFIICFVPLHVTRTV-GVVVKL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 302 IIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15922   240 FYPESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFRKS 283
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
72-344 4.06e-24

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 100.48  E-value: 4.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCkavhviy 149
Cdd:cd15051     1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNLTNYFIVSLAVTDLLLgLLVLPFSAIYELrGEWPLGPVFC------- 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 tvNLY---------SSVLILAFISLDRYLAIvhaTNSQR-PRKLLAEKVVYV--GVWIPALLLTI---------PDFifa 208
Cdd:cd15051    74 --NIYisldvmlctASILNLFAISLDRYLAI---TAPLRyPSRVTPRRVAIAlaAIWVVSLAVSFlpihlgwntPDG--- 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 209 NVSEADDRYICdRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCI------------IISKLSHSKGHQ---KRKALKT 273
Cdd:cd15051   146 RVQNGDTPNQC-RFELNPPYVLLVAIGTFYLPLLIMCGVYLRIFRIareqakrinaltPASTANSSKSAAtarEHKATVT 224
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 274 TVILILAFFACWLPYYIGISIDSFilleiikQGCEFENTVHkwiSITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15051   225 LAAVLGAFIICWFPYFTYFTYRGL-------CGDNINETAL---SVVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
76-343 5.68e-24

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 100.24  E-value: 5.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15205     5 ITYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISsNWLGGAFMCKMVPFVQSTAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQR---PRKllAEKVVYVgVWIPALLLTIPdFIFANVSEA------DDRYIC--DRF 222
Cdd:cd15205    85 VTSILTMTCIAVERHQGIVHPLKMKWqytNRR--AFTMLGL-VWIVSVIVGSP-MLFVQQLEVkydflyEKRHVCclERW 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFqhIMVGL-ILPGIVILSCYCIIISKL------------------SHSK-GHQKRKALKTTVILILAFF 282
Cdd:cd15205   161 YSPTQQKIYTTF--ILVILfLLPLTTMLFLYSRIGYELwikkrvgdasvlqtihgiEMSKiSRKKKRAVKMMVTVVLLFA 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 283 ACWLPYYIGISIDSFILLEIIKQGcefeNTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15205   239 VCWAPFHVVHMMIEYSNLENKYDG----VTIKLIFAIVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
72-344 8.45e-24

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 98.88  E-value: 8.45e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKaVHVIY 149
Cdd:cd15329     1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVaLLVMPLAIIYELSGyWPFGEILCD-VWISF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNL-YSSVLILAFISLDRYLAIVHATN--SQRPRKLLAekvVYVG-VWIPALLLTIPD-FIFANvsEADDRYICdrFYP 224
Cdd:cd15329    80 DVLLcTASILNLCAISVDRYLVITRPLTyaVKRTPKRMA---LMIAiVWLLSALISIPPlFGWKN--KVNDPGVC--QVS 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWvvvFQFQHIMVGLILPGIVILSCYcIIISKLSHSKghqkRKALKTTVILILAFFACWLPYYIGISIDSFIlleiik 304
Cdd:cd15329   153 QDFG---YQIYATFGAFYIPLIVMLVLY-YKIYRAAKSE----RKAIKTLGIIMGAFTLCWLPFFILALLRPFL------ 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 305 qGCEFENTVHKWIS-ITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15329   219 -KPIKCSCIPLWLSrLFLWLGYANSFLNPIIYAKFNREFRT 258
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
72-345 6.08e-23

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 97.13  E-value: 6.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD--AVANWYFGNFLCKAVHVIY 149
Cdd:cd15924     1 QLFPVLYTVIFFAGILLNGLAMWIF-FHIPSKSSFIIYLKNTVVADLLMILTFPFKILSdaGLGPWQLRTFVCRVTSVLF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15924    80 YFTMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKKCSFLKSELGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQF-QHIMVGLILPGIVIL-SCYCIIISKL-------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILL 300
Cdd:cd15924   160 KWHEIvNYICQVIFWIVFLLMiVCYTAITKKVyrsyrrvFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQT 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 301 EiIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15924   240 R-DVFDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRES 283
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
74-338 8.34e-23

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 96.69  E-value: 8.34e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTV 151
Cdd:cd15148     3 LAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNnqWTLGPLLCKVVGNLFYM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHAtnSQRPRKLLAEKVVYVG--VWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15148    83 NMYISIILLGFISLDRYLKINRS--SRRQKFLTRKWSIVACgvLWAVALVGFVPMIVLTEKNEESTKCFQYKDRKNAKGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILScYCIIISKL---SHSKGH------QKRKALKTTVILILaFFACWLPYYIGISIdsFILL 300
Cdd:cd15148   161 AIFNFLIVAMFWLVFLLLILS-YGKIAKKLlriSRDKPDfpnaakYNRTARKSFFVLFI-FTVCFVPYHAFRIF--YITS 236
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 301 EIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFL 338
Cdd:cd15148   237 QLQNNSCYWKEILHKTNEIMLLLSAFNSCLDPVMYFLL 274
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
76-345 1.08e-22

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 96.42  E-value: 1.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWAV-DAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15979     5 LLYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLAVfCMPFTLIpNLMGTFIFGEVICKAVAYLMGVSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVS--EADDRYI---CDRFYPNdlw 228
Cdd:cd15979    85 SVSTFSLVAIAIERYSAICNPLQSRVWQTRSHAYRVIAATWLLSGLIMIPYPVYSVTVpvPVGDRPRghqCRHAWPS--- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLIL---PGIVILSCYCIIISKLsHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFilleiiKQ 305
Cdd:cd15979   162 AQVRQAWYVLLLLILffiPGVVMIVAYGLISREL-YRGLLAKKRVIRMLVVIVAMFFLCWLPIFSANTWRAF------DP 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 306 GCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15979   235 LSAHRALSGAPISFIHLLSYTSACVNPLVYCFMNRRFRKA 274
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
72-343 4.05e-22

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 94.86  E-value: 4.05e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAV--ANWYFGNFLCKAVHVIY 149
Cdd:cd15370     1 VFLPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHIngNNWIYGEALCKVLIGFF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIFANVSEADDRYI--CDRFYPNDL 227
Cdd:cd15370    81 YGNMYCSILFMTCLSVQRYWVIVNPMSHSRKKANIA-IGISLAIWLLILLVTIPLYLVKQTVFIPALDIttCHDVLPEQL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 wVVVFQFQHIM----VGLILPGIVILSCYCIIISKLSHSK-----GHQKRKALKTTVILILAFFACWLPYYIGISIDSFI 298
Cdd:cd15370   160 -LVGDMFNYFLslaiGVFLFPAFLTAVAYVLMIRALKSSIndesiEKKRKRAIKLIVTVLVMYLICFTPSNLLLVVHYFL 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 LLEiikqgcEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15370   239 LKN------QGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
80-343 5.21e-22

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 94.33  E-value: 5.21e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN---WYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15053    10 LPLLT-VFGNVLVIMSVFRERSLQTATNYFIVSLAVADLLVAILVMPFAVYVEVNggkWYLGPILCDIYIAMDVMCSTAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICdRFYPND--LWVVVFQF 234
Cdd:cd15053    89 IFNLCAISIDRYIAVTQPIKYARQKNSKRVLLTIAIVWVVSAAIACPLLFGLNNVPYRDPEEC-RFYNPDfiIYSSISSF 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 qhimvglILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPYYIgISIDSFILLEIIKQGCEFENTVh 314
Cdd:cd15053   168 -------YIPCIVMLLLYYRIFRALR-----REKKATKTLAIVLGVFLFCWLPFFT-LNILNAICPKLQNQSCHVGPAL- 233
                         250       260
                  ....*....|....*....|....*....
gi 1127774881 315 kwISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15053   234 --FSLTTWLGYVNSFLNPIIYTIFNIEFR 260
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
83-343 9.41e-22

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 93.42  E-value: 9.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  83 LTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSSVLIL 160
Cdd:cd15326    12 LFAIVGNILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTvLPFSATLEILGyWVFGRIFCDIWAAVDVLCCTASILSL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 161 AFISLDRYLAIVHA----TNSQRPRKLLAekvvYVGVWIPALLLTIPDFIFANVSEADDRYICDrfYPNDLWVVVFQFqh 236
Cdd:cd15326    92 CAISIDRYIGVRHSlqypTIVTRKRAILA----LLGVWVLSTVISIGPLLGWKEPAPPDDKVCE--ITEEPFYALFSS-- 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 237 iMVGLILPGIVILSCYC---IIISKLSHSKghqkrKALKTTVILILAFFACWLPYYIGISIDSfiLLEIIKQGCEFENTV 313
Cdd:cd15326   164 -LGSFYIPLIVILVMYCrvyIVALKFSREK-----KAAKTLGIVVGMFILCWLPFFIALPLGS--LFSHLKPPETLFKII 235
                         250       260       270
                  ....*....|....*....|....*....|
gi 1127774881 314 HkWisiteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15326   236 F-W------LGYFNSCLNPIIYPCSSKEFK 258
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
78-343 1.41e-21

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 93.39  E-value: 1.41e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL---LFVITLPFwaVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd16002     7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEAsmsAFNTVINF--TYAIHNeWYYGLEYCKFHNFFPIAAV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYP---NDLWVV 230
Cdd:cd16002    85 FASIYSMTAIALDRYMAIIHPLQPRLSAT--ATKVVICVIWVLAFLLAFPQGYYSDTEEMPGRVVCYVEWPeheERKYET 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISKL------------SHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFI 298
Cdd:cd16002   163 VYHVCVTVLIYFLPLLVIGCAYTVVGITLwaseipgdssdrYHEQVSAKRKVVKMMIVVVCTFAICWLPYHI------YF 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 LLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd16002   237 LLQYFHPELYEQKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
78-343 1.89e-21

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 92.96  E-value: 1.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV-DAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15166     7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVyYAKDEWPFGDYFCRILGALTVFYPSIA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP-DFIFANVSEADDRYIC----DRFYPNDlwVVV 231
Cdd:cd15166    87 LWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPlLFLYEDPDKASNFTTClkmlDIIHLKE--VNV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHIMVGLILPGIVILSCYCIIISKLSHS-----KGHQKRKALKTTVILILAFFACWLPYYIgisidSFILLEIIKQg 306
Cdd:cd15166   165 LNFTRLIFFFLIPLFIMIGCYLVIIHNLVHGrtsklKPKVKEKSIRIIITLIVQVLVCFVPFHI-----CFAFLMLQNG- 238
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 307 cefENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15166   239 ---DNSYNPWAAFTTFLMNLSTCLDVILYYIVSKQFQ 272
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
76-344 2.95e-21

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 92.52  E-value: 2.95e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF-WAVD-AVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15167     5 YFYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVkIAVDlGIAPWKLKIFHCQVTACLIYINM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDF-IFANVSEADDRYICDRFyPNDL---WV 229
Cdd:cd15167    85 YLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNMaIPIKTIEEKPGVGCADF-KTEFgrhWH 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILScYCIIISKLSHSKGHQK----RKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQ 305
Cdd:cd15167   164 VLTNFICMAIFLNFSAIILIS-NFLVIRKLYRNKDSEEyrnaRQALVNILLVTAGYVICFVPYHIVRIPYTLSQSEVITD 242
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 306 gCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15167   243 -CSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRS 280
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
77-343 3.02e-21

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 92.24  E-value: 3.02e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAV-DAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15978     6 LYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLcLFCMPFTLIpNLLKDFIFGSAVCKTATYFMGISVS 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQR-PRKLLAEKVVyVGVWIPALLLTIPDFIFANV-----SEADDRYICDRFYPNDlw 228
Cdd:cd15978    86 VSTFNLVAISLERYSAICKPLKSRVwQTKSHALKVI-AATWCLSFTIMLPYPIYSNLvpftrINNSTGNMCRLLWPND-- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 vVVFQFQHIMVGLIL---PGIVILSCYCIIISKLSHSKGH--QKRKALKTTVILILAFFACWLPYYigiSIDSFILLEII 303
Cdd:cd15978   163 -VTQQSWYIFLLLILfliPGIVMMTAYGLISLELYRGIKFlmAKKRVIRMLIVIVILFFLCWTPIF---SANAWRAFDTR 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEFENTVhkwISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15978   239 SADRLLSGAP---ISFIHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
80-341 3.25e-21

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 92.49  E-value: 3.25e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15197     9 VLFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCvgLINVLTDIIWRITVEWRAGDFACKVIRYLQVVVTYAST 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFI-FANVSEADDRYICDRFYPNDL-WVVVFQFQ 235
Cdd:cd15197    89 YVLVALSIDRYDAICHPMNFSQSGR--QARVLICVAWILSALFSIPMLIiFEKTGLSNGEVQCWILWPEPWyWKVYMTIV 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 236 HIMVgLILPGIVILSCYCIII----------------------SKLSHSKG---HQKRKALKTTVILILAFFACWLPYYI 290
Cdd:cd15197   167 AFLV-FFIPATIISICYIIIVrtiwkkskiqvtinkaglhdgsSRRSSSRGiipRAKIKTIKMTFVIVTVFIICWSPYFV 245
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 291 GISIDSFILLEiikqgcefENTVHKWIS-ITEALAFFHCCLNPILYAFLGAK 341
Cdd:cd15197   246 FDLLDVFGLLP--------RSKTKIAAAtFIQSLAPLNSAINPLIYCLFSTH 289
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
76-337 3.42e-21

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 92.32  E-value: 3.42e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGyqKKLRSM---TDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYT 150
Cdd:cd15170     5 AVYIITFLIGLPANLLAFYTFI--RKVRRKptpIDILLLNLTVSDLIFLLFLPFKMAEAASGmiWPLPYFLCPLSSFIFF 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPA-----LLLTIPDFIFANVSEADDRYIC-DRFYP 224
Cdd:cd15170    83 STIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAfshcsIVYIVEYHIDSENTSVTNNSRCyDNFTP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGL-ILPGIVILSCYCI---IISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGiSIDSFIll 300
Cdd:cd15170   163 EQLKILLPVRLELFLVLfCIPFLITCFCYINfirILSSLPHISRQRKQRAIGLAVATLLNFIVCFAPYNIS-HVVGFI-- 239
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 301 eiikqgcefENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15170   240 ---------QRKSPEWRMYALLLSTLNACLDPIIFYF 267
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
75-343 4.11e-21

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 92.10  E-value: 4.11e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVA-NWYFGNFLCKAVHVIYTVN 152
Cdd:cd14977     4 MSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLTkDWLFGDVMCKLVPFIQVTS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY-----IC-------- 219
Cdd:cd14977    84 LGVTVFSLCALSIDRYRAAVNSMPMQTIGACLSTCVKLAVIWVGSVLLAVPEAVLSTVARESSLDnssltVCimkpstpf 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPN--DLWVVVFQFqhimvglILPGIVILSCYCIIISKLS--------HSKGH--QKRKALKTTVILILAFFACWLP 287
Cdd:cd14977   164 AETYPKarSWWLFGCYF-------CLPLAFTAVCYLLMARTLIraakeytrGTKKHmkQRRQLAKTVLCLVLVFAFCWLP 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 288 YYIGISIDSFILLEIIKQGCEFENTVHkWISITeaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd14977   237 EHISNILRATLYNEVLIDTRSTLDILD-LIGQF--LSFFNSCVNPIALYLLSEPFR 289
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
78-343 7.38e-21

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 91.53  E-value: 7.38e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI--TLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd16003     7 YGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAfnTLINFIYALHSEWYFGEAYCRFHNFFPITSVFA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATnsqRPR-KLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLwVVVFQF 234
Cdd:cd16003    87 SIYSMTAIAVDRYMAIIDPL---KPRlSATATKVVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVAWPGGP-DQHFTY 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVGLI--LPGIVILSCYCII------------ISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidSFILL 300
Cdd:cd16003   163 HIIVIVLVycLPLLVMGITYTIVgitlwggeipgdTSDKYHEQLRAKRKVVKMMIIVVLTFAICWLPYHI-----YFIVT 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1127774881 301 EIIKQgcefentVHKWISITEA------LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd16003   238 GLYQQ-------LNRWKYIQQVylasfwLAMSSTMYNPIIYCCLNKRFR 279
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
76-344 8.39e-21

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 91.44  E-value: 8.39e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd16004     5 IAYSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMaAFNTAFNFVYASHNdWYFGLEFCRFQNFFPITAM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATnsqRPR-KLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL---WV 229
Cdd:cd16004    85 FVSIYSMTAIAADRYMAIIHPF---KPRlSAGSTKVVIAGIWLVALALAFPQCFYSTVTMDQGRTKCIVAWPGDSggkHQ 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCII-------------ISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDS 296
Cdd:cd16004   162 LTYHLAVIVLIYLLPLAVMFVTYSIIgitlwrsavpghqAHGAYHRQLQAKKKFVKTMVVVVVTFAICWLPYHLYFILGS 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 297 FiLLEIIKQgcEFENTVHKWISIteaLAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd16004   242 F-NEDIYCQ--KYIQQVYLAIFW---LAMSSTMYNPIIYCCLNQRFRS 283
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
73-345 1.00e-20

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 90.97  E-value: 1.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd14991     2 ILPPLLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRgeHWIFGEAWCRVNLFMLS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIV---HATNSQRPRKLLAekvVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL 227
Cdd:cd14991    82 VNRSASIAFLTAVALDRYFKVVhphHRVNRMSVKAAAG---VAGLLWALVLLLTLPLLLSTLLTVNSNKSSCHSFSSYTK 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGL--ILPGIVILSC----YCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPyyigiSIDSFILLE 301
Cdd:cd14991   159 PSLSIRWHNALFLLefFLPLGLIVFCsvriACNLRIRQSLGKQARVQRAIRLVFLVVIVFVLCFLP-----SIIAGLLAL 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 302 IIK--QGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14991   234 VFKnlGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFRNS 279
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
74-343 1.08e-20

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 91.11  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPfwAVDA----VANWYFGNFLCKAVHVIY 149
Cdd:cd15124     3 IPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCA--PVDAsrylADEWLFGRVGCKLIPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRF-----YP 224
Cdd:cd15124    81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFSDLHPFYDKSTNKTFvscapYP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 --NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS-------------KGHQKRKALKTTVILILAFFA-CWLPY 288
Cdd:cd15124   161 hsNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSaynlpvegnvhvrRQIESRKRLAKTVLVFVGLFAfCWLPN 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 289 YIGISIDSFILLEIIKQGCEFENTVhkwisITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15124   241 HIIYLYRSYHYSEVDTSMLHFVSSI-----CARILAFTNSCVNPFALYLLSKSFR 290
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
72-345 1.72e-20

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 90.26  E-value: 1.72e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV-DA-VANWYFGNFLCKAVHVIY 149
Cdd:cd15150     1 VIFPLLYTVLFIVGLTMNGLAMRVF-FQIPSKSNFIIFLKNTVISDLLMILTFPFKILsDAkLGSWPLRGFVCQVTSVIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15150    80 YFTMYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNMILTNRQPTPKNVKKCSLLKSEFGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPG--IVILSCYCIIISKLSHS------KGHQKRKALKTTVILILA-FFACWLPYYIGiSIDSFILL 300
Cdd:cd15150   160 VWHEIVNYICQVIFWVnfLIVIVCYTLITKELYKSykrtrgVGKVSRKKVNVKVFIIIAvFFICFVPFHFA-RIPYTLSQ 238
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 301 EIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15150   239 TRDVFDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNS 283
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
72-343 1.82e-20

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 90.47  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV-ITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15389     1 ALLIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITlLNTPFTLVRFVNStWVFGKIMCHLSRFAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATnsqRPRKLLAEKVVYVGV-WIPALLLTIPDFIFANV-----SEADDRYIC--DR 221
Cdd:cd15389    81 YCSVYVSTLTLTAIALDRHRVILHPL---KPRITPCQGVVVIAIiWIMASCLSLPHAIYQKLvefeySNERTRSRClpSF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---------------SHSKghQKRKALKTTVILILAFFACWL 286
Cdd:cd15389   158 PEPSDLFWKYLDLATFILQYVLPLLIIGVAYTRVAKKLwlrnaigdvtteqyvAQRR--KKKKTIKMLMLVVLLFAICWL 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 287 P---YYIGISIDSFilleiikqgcEFENTVH---KWISITEAlaffhcCLNPILYAFLGAKFK 343
Cdd:cd15389   236 PlncYHVLLSSHPI----------RSNSALFfafHWLAMSST------CYNPFIYCWLNDSFR 282
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
77-335 2.00e-20

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 90.19  E-value: 2.00e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAV-DAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15384     6 VLAVMFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVtFFCIPSEAIwAYTVAWLAGNTMCKLVKYLQVFGLY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVH----ATNSQRPRKLLAekvvyvGVWIPALLLTIPDFIFANVSEA---DDRYICDRFY-PND 226
Cdd:cd15384    86 LSTYITVLISLDRCVAILYpmkrNQAPERVRRMVT------VAWILSPIFSIPQAVIFHVERGpfvEDFHQCVTYGfYTA 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LW--------VVVFQFqhimvglILPGIVILSCY-CIIISKLSHSKGHQ--------------------KRKALKTTVIL 277
Cdd:cd15384   160 EWqeqlynmlSLVFMF-------PIPLVIMVTCYvLIFITLSKSSRDFQgleiytrnrgpnrqrlfhkaKVKSLRMSAVI 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 278 ILAFFACWLPYYIgisidsfILLEIIkqgceFENtvHKWIS--ITEALAFF---HCCLNPILY 335
Cdd:cd15384   233 VTAFILCWTPYYV-------IMIWFL-----FFN--PYPLNdiLFDVIFFFgmsNSCVNPLIY 281
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
77-343 4.90e-20

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 88.86  E-value: 4.90e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYfGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15164     6 IYIPILFFGLLFNVLALWVFCCKMKKWTETRVYMINLAVADCCLLFSLPFVLYFLKHSWP-DDELCLVLQSIYFINRYMS 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIpallLTIPDFIFANVSEADDRYIC---DRFYPNdLWVVVFq 233
Cdd:cd15164    85 IYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWV----LVIISVSLRLAWEEQEENFCfgkTSTRPS-KRTLIF- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 fqhIMVGLILPGIVILSCYCIIISKLSHSKG---HQK---RKALKTTVILILAFFACWLPYYIGISIdSFIlLEIIKQGC 307
Cdd:cd15164   159 ---SLLGFFIPLIILSFCSIQVIRSLKKKKKtnpHEEkliQKAIYIVSANLIVFIVCFLPLHIGLLV-RFV-MESNKASC 233
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 308 EFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15164   234 SLIQNIRNFIYVASCLANANCCLDAICYYFVAKEFQ 269
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
72-345 5.26e-20

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 88.41  E-value: 5.26e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAV-DAVANWYFGNFLCKAVHVIY 149
Cdd:cd15325     1 IVLGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTvLPFSAIfEILGYWAFGRVFCNIWAAVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVH-----ATNSQRpRKLLAekvvYVGVWIPALLLTIPDFIFANVSEADDRYICDrfYP 224
Cdd:cd15325    81 VLCCTASIMSLCIISIDRYIGVSYplrypSIMTER-RGLLA----LLCVWVLSLVISIGPLFGWKEPAPEDETICQ--IT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQfqhIMVGLILPGIVILSCYC-IIISKLSHSKghqKRKALKTTVILILAFFACWLPYYIGISIDSFIlleii 303
Cdd:cd15325   154 EEPGYALFS---ALGSFYLPLAIILVMYCrVYVVALKFSR---EKKAAKTLGIVVGCFVLCWLPFFLVMPIGSIF----- 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 304 kQGCEFENTVHKwisITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15325   223 -PAYKPSDTVFK---ITFWLGYFNSCINPIIYPCSSQEFKKA 260
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
80-343 6.80e-20

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 88.96  E-value: 6.80e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGY-QKKLRSMTDKYRLHLSVADLLF-VITLPfwaVDAVAN----WYFGNFLCKAVHVIYTVNL 153
Cdd:cd15383     9 VLFVLSACSNLAVLWSATRnRRRKLSHVRILILHLAAADLLVtFVVMP---LDAAWNvtvqWYAGDLACRLLMFLKLFAM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPD-FIFANV--SEADDRYICDR--FYPNDLW 228
Cdd:cd15383    86 YSSAFVTVVISLDRHAAILNPLAIGSARR--RNRIMLCAAWGLSALLALPQlFLFHTVtaTPPVNFTQCAThgSFPAHWQ 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCY-CIIIS---KLSHSKGHQKR----------------KALKTTVILILAFFACWLPY 288
Cdd:cd15383   164 ETLYNMFTFFCLFLLPLLIMIFCYtRILLEisrRMKEKKDSAKNevalrsssdnipkarmRTLKMTIVIVSSFIVCWTPY 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 289 YIgISIDSFILLEIIkqgcefENTVHKWISITEAL-AFFHCCLNPILYAFLGAKFK 343
Cdd:cd15383   244 YL-LGLWYWFSPEML------EQTVPESLSHILFLfGLLNACLDPLIYGLFTISFR 292
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
72-337 9.08e-20

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 88.45  E-value: 9.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKaVHVIY 149
Cdd:cd15314     1 VLLYIFLGLISLVTVCGNLLVIISIAHFKQLHTPTNYLILSLAVADLLVgGLVMPPSMVRSVETcWYFGDLFCK-IHSSF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNL-YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVW-IPALLLTIPDFIFANVSEADDRYI-----CDRF 222
Cdd:cd15314    80 DITLcTASILNLCFISIDRYYAVCQPLLYRSKITVRVVLVMILISWsVSALVGFGIIFLELNIKGIYYNHVaceggCLVF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YpndlwVVVFQFQHIMVGLILPGIVILSCYCII----------ISKLSHSKGH----QKRKALKTTVILILAFFACWLPY 288
Cdd:cd15314   160 F-----SKVSSVVGSVFSFYIPAVIMLCIYLKIflvaqrqarsIQSARTKSGAssskMERKATKTLAIVMGVFLLCWTPF 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1127774881 289 YIGISIDSFILLEIIKQGCEfentVHKWISITEALaffhccLNPILYAF 337
Cdd:cd15314   235 FLCNIIDPFINYSIPPVLIE----VLNWLGYSNST------LNPFIYAF 273
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
72-343 1.00e-19

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 87.93  E-value: 1.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAV-DAVANWYFGNFLCKAVHVIY 149
Cdd:cd15062     1 IVVGVALGAFILFAIGGNLLVILSVACNRHLRTPTHYFIVNLAVADLLLSFTvLPFSATlEVLGYWAFGRIFCDVWAAVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTI-PDFIFANVSEADDRyIC----DRFYp 224
Cdd:cd15062    81 VLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTARRATVALLIVWVLSLVISIgPLLGWKEPAPADEQ-ACgvneEPGY- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 ndlwvVVFQfqhIMVGLILPGIVILSCYC-IIISKLSHSKghqKRKALKTTVILILAFFACWLPYYIGISIDSFIlleii 303
Cdd:cd15062   159 -----VLFS---SLGSFYLPLAIILVMYCrVYVVAFKFSR---EKKAAKTLGIVVGAFVLCWFPFFVVLPLGSLF----- 222
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 kQGCEFENTVHKwisITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15062   223 -STLKPPEPVFK---VVFWLGYFNSCLNPIIYPCSSREFK 258
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
72-343 1.30e-19

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 87.87  E-value: 1.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIysiifLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLP--FWAVDAVANWYFGNFLCKAVHVIY 149
Cdd:cd15000     5 MFLPVV-----LFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPwmFLVHDFFQNYVLGSVGCKLEGFLE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15000    80 GSLLLASVLALCAVSYDRLTAIVLPSEARLTKR--GAKIVIVITWIVGLLLALPLAIYRSYRERQWKNFLETYCAENTQV 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLI-LPGIVILSCYCIIISKLSHS------KGHQ-----KRKALKTTVILILAFFACWLPYYIGISIDSF 297
Cdd:cd15000   158 LPIYWHVIITVLVwLPLGIMLICYSAIFWKLDKYerrvlrREHPsvvryKKKAAKTLFIVLITFVVCRIPFTALIFYRYK 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 298 ILLEIIKQGcEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15000   238 LVPNDNTQN-SVSGSFHILWFASKYLMFLNAAVNPLIYGFTNENFR 282
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
79-343 1.37e-19

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 87.27  E-value: 1.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWA-VDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15327     8 AIFILMAIVGNILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTvLPFSAtLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHatnSQRPRKLLAEK---VVYVGVWIPALLLTIPDFIFANVSEADDRYIC----DRFYPndLWV 229
Cdd:cd15327    88 ILSLCVISVDRYVGVKH---SLKYPTIMTERkagVILVLLWVSSMVISIGPLLGWKEPPPPDESICsiteEPGYA--LFS 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFqhimvglILPGIVILSCYC-IIISKLSHSKghqKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikQGCE 308
Cdd:cd15327   163 SLFSF-------YLPLMVILVMYFrVYVVALKFSR---EKKAAKTLAIVVGVFILCWFPFFFVLPLGSFF------PALK 226
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISiteALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15327   227 PSEMVFKVIF---WLGYFNSCVNPIIYPCSSKEFK 258
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
78-343 1.98e-19

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 87.47  E-value: 1.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVM-GYQKKLRSMTdKYRLHLSVADLLFVITLP---FWAVDAvaNWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15152     7 YTVILIPGLIGNVLALWVFyAYVKETKRAV-IFMINLAIADLLQVLSLPlriFYYLNK--SWPFGKFLCMFCFYLKYVNM 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGvWIPALLLTIPdFIFANVSEADDRYICDRFYP----NDLWV 229
Cdd:cd15152    84 YASIYFLVCISVRRCLYLIYPFRYNDCKRKCDVYISIAG-WLVVCVGCLP-FPLLRQSQDTNPTCCFADLPlrnvGLTTS 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKL------SHSKGhQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEII 303
Cdd:cd15152   162 VIMLTIAELTGFVTPLLIVLYCSWKTVMSLrektpvLQDLG-EKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKI 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15152   241 KS-CTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFK 279
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
78-343 3.07e-19

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 86.90  E-value: 3.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15123     7 YAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIADtWLFGRIGCKLLSFIQLTSVGV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANV---SEADDRYICDRFYPNDLWVVVF 232
Cdd:cd15123    87 SVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFSDLysfRDPEKNTTFEACAPYPVSEKIL 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHIMVGLILPGIV---ILSCYCIIISKL-----------SHSKGHQK---RKALKTTVILILAFFA-CWLPYYIGISI 294
Cdd:cd15123   167 QEIHSLLCFLVFYIIplsIISVYYFLIARTlykstfnmpaeEHSHARKQiesRKRVAKTVLVLVALFAfCWLPNHILYLY 246
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 295 DSFILLEIIKqgcefENTVHKWISI-TEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15123   247 RSFTYHTSVD-----SSAFHLIATIfSRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
77-346 3.10e-19

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 86.77  E-value: 3.10e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF--WAVDAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15928     6 VCSVLMLVGASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDLLIFLVLPLdlYRLWRYRPWRFGDLLCRLMYFFSETCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE---ADDRYICD-RFYPND---- 226
Cdd:cd15928    86 ASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIVSAGPALVLVGVEHiqgQQTPRGFEcTVVNVSsgll 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ---LWVVVFQFqhimvglILPGIVILSCYCIIISKLSHSKGHQK-----------RKALKTTVILILAFFACWLPYYIGI 292
Cdd:cd15928   166 svmLWVSTSFF-------FVPMVCLSLLYGLIGRALWDRRQRSRtagasrrdnnhRQTVRMLAVIVLAFVLCWLPFHVGR 238
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 293 SIDSFILleiikQGCEFENTVHKWISITEALAFF-HCCLNPILYAFLGAKFKTSA 346
Cdd:cd15928   239 VIFNHSR-----ASTKHLHYVSQYFNLVSFVLFYlSAAINPILYNLMSKRYRYAV 288
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
80-346 4.25e-19

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 86.39  E-value: 4.25e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF--WAVDAVANWYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15132     9 ILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFdlYRLWKSRPWIFGEFLCRLYHYISEGCTYATI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICD-------RFYPND---- 226
Cdd:cd15132    89 LHITALSIERYLAICFPLRAKVLVTRRRVKCVIAALWAFALLSAGPFLFLVGVEQDNNIHPDDfsreckhTPYAVSsgll 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ---LWVVVFQFqhimvglILPGIVILSCYCIIISKLSHSKGHQK-----------RKALKTTVILILAFFACWLPYYIGI 292
Cdd:cd15132   169 gimIWVTTTYF-------FLPMLCLSFLYGFIGRKLWKSKNDLRgpnaaarershRQTVRILAVVVLAFIICWLPFHIGR 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 293 SIdsfilleiikqgceFENT-------VHKWISITEALAFF-HCCLNPILYAFLGAKFKTSA 346
Cdd:cd15132   242 IL--------------FANTedyrtmmFSQYFNIVAMQLFYlSASINPILYNLISRKYRAAA 289
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
72-343 4.51e-19

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 86.33  E-value: 4.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15397     1 VFLVVSYSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLMDyWIFGEVLCKMTPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATnSQRPRKLLAEKVVYVgVWIPALLLTIP--------DFIFANVSEA----DDRY 217
Cdd:cd15397    81 CMSVTVSILSLVLIALERHQLIINPT-GWKPSVSQAYLAVVV-IWMLACFISLPflafhiltDEPYKNLSHFfaplADKA 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 218 ICDRFYPND-------LWVVVFQFqhimvglILPGIVILSCYCIIISKLS------HSKGHQKRKALKTTVI------LI 278
Cdd:cd15397   159 VCTESWPSEhhklaytTWLLLFQY-------CLPLLFILVCYLRIYLRLRrrkdmlERRGEYNRRAGHSKRInvmlvsLV 231
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 279 LAFFACWLPYYIGISIDSFIlLEIIKQgCEfentvHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15397   232 AAFALCWLPLNVFNAIADWN-HEAIPH-CQ-----HNLIfSLCHLAAMASTCVNPIIYGFLNSNFK 290
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
76-345 4.67e-19

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 85.89  E-value: 4.67e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWA-VDAVANWYFGNFLC---KAVHVIYT 150
Cdd:cd15066     4 FAMTLIILAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALcAMTFNAsVEITGRWMFGYFMCdvwNSLDVYFS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VnlySSVLILAFISLDRYLAIVHATnsQRPRKLLAEKV--VYVGVWI-PALLLTIPDFI-FANVSE-----ADDRYICdR 221
Cdd:cd15066    84 T---ASILHLCCISVDRYYAIVQPL--EYPSKMTKRRVaiMLANVWIsPALISFLPIFLgWYTTEEhlqyrKTHPDQC-E 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQfqhiMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGisidsFILLE 301
Cdd:cd15066   158 FVVNKIYALISS----SVSFWIPCIVMIFTYYRI-----YLEAKREHKAAKTLGIIMGAFILCWLPFFLW-----YVTTT 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 302 IIKQGCEFENTVhkwISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15066   224 LCGDACPYPPIL---VSILFWIGYFNSTLNPLIYAYFNRDFREA 264
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
72-345 5.43e-19

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 85.46  E-value: 5.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAV-DAVANWYFGNFLCK---AVH 146
Cdd:cd15064     1 VLISVLLSLIILATILGNALVIAAILLTRKLHTPANYLIASLAVADLLVaVLVMPLSAVyELTGRWILGQVLCDiwiSLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 147 VIYTVnlySSVLILAFISLDRYLAI---VHATNSQRPRklLAEKVVYVgVWIPALLLTIPDFIF---ANVSEADDRYICD 220
Cdd:cd15064    81 VTCCT---ASILHLCVIALDRYWAItdaVEYAHKRTPK--RAAVMIAL-VWTLSICISLPPLFGwrtPDSEDPSECLISQ 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 221 RfypndlwvVVFQFQHIMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPyyigisidsFILL 300
Cdd:cd15064   155 D--------IGYTIFSTFGAFYIPLLLMLILYWKIYRAAA-----RERKAAKTLGIILGAFIVCWLP---------FFLV 212
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 301 EIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15064   213 ALIVPLCSHCWIPLALKSFFLWLGYFNSLINPLIYTFFNKDFRKA 257
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
72-343 6.43e-19

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 85.49  E-value: 6.43e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMgYQK-KLRSMTDKYRLHLSVAD-LLFVITLPFWAVDAV-ANWYFGNFLCKAVHVI 148
Cdd:cd15213     1 ITLAILMILMIFVGFLGNSIVCLIV-YQKpAMRSAINLLLANLAFSDiMLSLVCMPFAAVTIItGRWIFGDIFCRISAML 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllaEKVVYVGVWIPALLLTIPDFIFANVSEADDRYI-CDRFYPNDL 227
Cdd:cd15213    80 YWFFVLEGVAILLIISVDRYLIIVQRQDKLNPHR---AKILIAVSWVLSFCVSFPPLVGWGKYEFPPRAPqCVLGYTESP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSkghqKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIKQGC 307
Cdd:cd15213   157 ADRIYVVLLLVAVFFIPFLIMLYSYFCILNTVRSF----KTRAFTTILILFIGFSVCWLPYTV------YSLLSVFSRYS 226
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 308 EFENTVHKWISIteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15213   227 SSFYVISTCLLW---LSYLKSAFNPVIYCWRIKKFR 259
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
76-337 7.38e-19

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 85.94  E-value: 7.38e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTgIVGNGLVIL-VMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFlCKaVHVIYTVN 152
Cdd:cd15057     6 ILYLLVLLT-LLGNALVIAaVLRFRHLRSKVTNYFIVSLAVSDLLVAILvMPWAAVNEVAGyWPFGSF-CD-VWVSFDIM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYS-SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLT-IPdfIFANVSEADDRYICDRFY--PNDLW 228
Cdd:cd15057    83 CSTaSILNLCVISVDRYWAISSPFRYERRMTRRRAFIMIAVAWTLSALISfIP--VQLGWHRADDTSEALALYadPCQCD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLI---LPGIVILSCYCII----------ISKLSHSKGHQK-------------RKALKTTVILILAFF 282
Cdd:cd15057   161 SSLNRTYAISSSLIsfyIPVAIMIVTYTRIyriarrqirrIAALERAAQESTnpdsslrsslrreTKALKTLSIIMGVFV 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 283 ACWLPYYIGISIDSFILLEIIKQGCEFENTvhkwISITEALAFFHCCLNPILYAF 337
Cdd:cd15057   241 CCWLPFFILNCVLPFCDLRTAQFPCVPDTT----FIVFVWLGWANSSLNPIIYAF 291
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
80-353 8.09e-19

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 85.38  E-value: 8.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTdKYRLHLSVADLLFVITLPFWAVDAVANWY-FGNFLCKAVHVIYTVNLYSSVL 158
Cdd:cd14973     9 LLSLCGLVGNGLVLWLLGFRIKRNPFS-VYILNLAAADFLFLSCQAIQSLEDLLGGSlPGFALCRLLATLMFFSYTVGLS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIV--HATNSQRPRKLLAekVVYVGVWIPALLLTIPDFIFANVSeaddryicdRFYPNDLWVVVFQFQH 236
Cdd:cd14973    88 LLAAISTERCLSVLfpIWYRCHRPKHLSA--VVCALLWALSLLLSVLESYFCGFL---------FWKFNESACRTFNFLS 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 237 IMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIkqgcefentvHKW 316
Cdd:cd14973   157 ALLFLLLFLVMCVSSLTLLIRVQCSSQRRPPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFSNYLF----------HTF 226
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 317 ISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSV 353
Cdd:cd14973   227 HPISDLLSCVNSSANPIIYFFVGSLRGRRLREPLRVV 263
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
76-343 8.48e-19

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 85.62  E-value: 8.48e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15153     5 TTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQhTWPFGRFLCLLCFYLKYLNMY 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRpRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRfypnDLWVVVFQF 234
Cdd:cd15153    85 ASICFLTCISIQRCFFLLHPFKARD-WKRRYDVGISAAVWIVVGLACLPFPLLRSKSLSNNNRSCFA----DLGMKKLNF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHI--------MVGLILPGIVILSC-YCIIISKLSHSKGHQ----KRKALKTTVILILAFFACWLPYYIGISIDSFILLE 301
Cdd:cd15153   160 GAAiammtvaeLFGFVIPLFIIAWCtWKTENSLRQRNKQQQstseKQKALRMVRMCAAVFFICFAPYHINFLFYLMVSES 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 302 IIKQgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15153   240 IITN-CEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQ 280
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
74-343 2.13e-18

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 84.62  E-value: 2.13e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPfwaVDA----VANWYFGNFLCKAVHVI 148
Cdd:cd15125     3 IPSLYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTcVP---VDAsryfYEEWMFGTVGCKLIPVI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY----------- 217
Cdd:cd15125    80 QLTSVGVSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDnttftacipyp 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 218 ICDRFYPNDLWVVVFqfqhiMVGLILPgIVILSCYCIIISKL-------------SHSKGH-QKRKALKTTVILILAFFA 283
Cdd:cd15125   160 QTDEMHPKIHSVLIF-----LVYFLIP-LAIISIYYYHIAKTliksahnipgeysEHSKRQmETRKRLAKIVLVFVGLFA 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 284 -CWLPYYIGISIDSFILLEIIKQGCEFENTVhkwisITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15125   234 fCWFPNHVLYMYRSFNYNEIDSSLGHMIVTL-----VARVLSFCNSCVNPFALYLLSESFR 289
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
77-346 2.97e-18

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 84.22  E-value: 2.97e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVANW------YFGNFLCKAVHVIY 149
Cdd:cd14978     6 VLPVICIFGIIGNILNLVVL-TRKSMRSSTNVYLAALAVSDILVLLSaLPLFLLPYIADYsssflsYFYAYFLPYIYPLA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR-------YICDRF 222
Cdd:cd14978    85 NTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCnnnsyyyVIPTLL 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQ-HIMVGLILPGIVILSCYCIII----------------SKLSHSKGHQKRKALKTTVILILAFFACW 285
Cdd:cd14978   165 RQNETYLLKYYFWlYAIFVVLLPFILLLILNILLIralrkskkrrrllrrrRRLLSRSQRRERRTTIMLIAVVIVFLICN 244
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 286 LPYYIgisidsFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd14978   245 LPAGI------LNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
77-345 3.38e-18

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 83.25  E-value: 3.38e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL-LFVITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15060     6 LLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLaVAIFVLPLNVAYFLLgKWLFGIHLCQMWLTCDILCCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEaddryicDRFYPND-------- 226
Cdd:cd15060    86 ASILNLCAIALDRYWAIHDPINYAQKRTLKRVLLMIVVVWALSALISVPPLIGWNDWP-------ENFTETTpctlteek 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPGIVILSCYcIIISKlshskghqKRKALKTTVILILAFFACWLPyyigisidsFILLEIIKQG 306
Cdd:cd15060   159 GYVIYSSSGSFFIPLLIMTIVYVKIF-IATSK--------ERRAARTLGIIMGVFVVCWLP---------FFLMYVILPF 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 307 CEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15060   221 CETCSPSAKVVNFITWLGYVNSALNPVIYTIFNLDFRRA 259
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
77-345 3.66e-18

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 83.76  E-value: 3.66e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-TLPFWAVDAVANW--YFGNFLCKAVHVIYTVNL 153
Cdd:cd15357     6 VYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfGMPLEVYEMWSNYpfLFGPVGCYFKTALFETVC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVH----ATNSQRPRKLLaekvVYVGVWIPALLLTIPDF--------IFANVSEADDRYICDR 221
Cdd:cd15357    86 FASILSVTTVSVERYVAILHpfraKLNSTRERALK----IIVVLWVLSVLFSIPNTsihgiklqYFPNGTLIPDSATCTV 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQFQHIMVgLILPGIVILSCYCIIISKLSHSKGHQ-----------KRKAL-KTTVILILAFFACWLPYY 289
Cdd:cd15357   162 VKPLWIYNLIIQITSLLF-YVLPMGVISVLYYLMGLKLRGDKSLEademnvniqrpSRKSVtKMLFVLVLVFAICWAPFH 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 290 IGISIDSFIlLEIIKQGCEFENTVHkwiSITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15357   241 VDRLFFSFV-VEWTEPLANVFNLIH---VVSGVFFYLSSAVNPIIYNLLSRRFRTA 292
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
73-336 1.12e-17

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 82.62  E-value: 1.12e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd15079     2 LLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSFYEgWALGPLGCQIYAFLGSL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIFanvseaddryICDRFYP------- 224
Cdd:cd15079    82 SGIGSIWTNAAIAYDRYNVIVKPLNGNPLTRGKA-LLLILFIWLYALPWALLPLLF----------GWGRYVPegfltsc 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 ------NDLWVVVFQFQHIMVGLILPGIVILSCYCIIIS-------------------KLSHSKGHQKRKA----LKTTV 275
Cdd:cd15079   151 sfdyltRDWNTRSFVATIFVFAYVIPLIIIIYCYSFIVKavfahekalreqakkmnvvSLRSNADANKQSAeiriAKVAL 230
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 276 ILILAFFACWLPY----YIGISIDSFILLEIIkqgcefentvhkwiSITEAL-AFFHCCLNPILYA 336
Cdd:cd15079   231 TNVFLWFIAWTPYavvaLIGAFGNQSLLTPLV--------------SMIPALfAKTAACYNPIVYA 282
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
76-337 1.16e-17

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 82.42  E-value: 1.16e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMG-YQKKLRSMTDKYRLHLSVADLLFVITLPFWAVD--AVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd15104     4 VILAVLSPLIITGNLLVIVALLkLIRKKDTKSNCFLLNLAIADFLVGLAIPGLATDelLSDGENTQKVLCLLRMCFVITS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIvhaTNSQRPRKLLAEKVVY---VGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15104    84 CAASVLSLAAIAFDRYLAL---KQPLRYKQIMTGKSAGaliAGLWLYSGLIGFLPLISPQFQQTSYKGKCSFFAAFHPRV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFqhimVGLILPG-IVILSCYCII----------ISKLSHSKGHQKR--------KALKTTVILILAFFACWLPYYI 290
Cdd:cd15104   161 LLVLS----CMVFFPAlLLFVFCYCDIlkiarvhsraIYKVEHALARQIHprrtlsdfKAARTVAVLIGCFLLSWLPFQI 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1127774881 291 GisidsfILLEIIKQGCEFENTVHKWISiteALAFFHCCLNPILYAF 337
Cdd:cd15104   237 T------GLVQALCDECKLYDVLEDYLW---LLGLCNSLLNPWIYAF 274
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
74-345 1.27e-17

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 81.91  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPF-WAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15323     3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVaTLVMPFsLANELMGYWYFGQVWCNIYLALDVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHAT--NSQR-PRKLlaeKVVYVGVWIPALLLTIPDFIFANVSEADDRY-ICDrfYPNDL 227
Cdd:cd15323    83 FCTSSIVHLCAISLDRYWSVTQAVeyNLKRtPRRV---KAIIVTVWLISAVISFPPLISMYRDPEGDVYpQCK--LNDET 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQfqhiMVGLILPGIVILSCYCIIISKLshSKGHQKRKALKTTVILILaFFACWLPYYIgisidSFILLEIIKQGC 307
Cdd:cd15323   158 WYILSS----CIGSFFAPCLIMILVYIRIYRV--AKAREKRFTFVLAVVMGV-FVVCWFPFFF-----SYSLYGICREAC 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 308 EFENTVHK---WIsitealAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15323   226 EVPEPLFKfffWI------GYCNSSLNPVIYTIFNQDFRRS 260
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
81-343 1.59e-17

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 82.02  E-value: 1.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  81 IFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVAD-LLFVITLPFWAVDAVAN-WYFGNFLCKaVHVIYTVNL-YSSV 157
Cdd:cd15312    11 ILLT-VFGNLMVIISISHFKQLHSPTNFLILSLAITDfLLGFLVMPYSMVRSVEScWYFGDLFCK-IHSSLDMMLsTTSI 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWI-PALLLTIPDFIFANVSEADDRYI---CDRFYP---NDLWVV 230
Cdd:cd15312    89 FHLCFIAVDRYYAVCDPLHYRTKITTPVIKVFLVISWSvPCLFAFGVVFSEVNLEGIEDYVAlvsCTGSCVlifNKLWGV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQfqhiMVGLILPGIVILSCYCIIIS-------KLSHSKGHQK------------RKALKTTVILILAFFACWLPYYIG 291
Cdd:cd15312   169 IAS----LIAFFIPGTVMIGIYIKIFFvarkhakVINNRPSVTKgdsknklskkkeRKAAKTLSIVMGVFLLCWLPFFVA 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 292 ISIDSFIlleiikqgcEFENTVHKWISITeALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15312   245 TLIDPFL---------NFSTPVDLFDALV-WLGYFNSTCNPLIYGFFYPWFQ 286
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
79-343 1.69e-17

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 81.25  E-value: 1.69e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15067     8 LFCLVT-VAGNLLVILAVLRERYLRTVTNYFIVSLAVADLLVgSIVMPFSILHEMTGgyWLFGRDWCDVWHSFDVLASTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIV----HATNSQRPRKLLAEKVVyvgvWIPALLLTIPDFIF--ANVSEADDRYICdrFYPNDLWV 229
Cdd:cd15067    87 SILNLCVISLDRYWAITdpisYPSRMTKRRALIMIALV----WICSALISFPAIAWwrAVDPGPSPPNQC--LFTDDSGY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQfqhIMVGLILPGIVILSCYCIIISKLSHskghqKRKALKTTVILILAFFACWLPYYIgisidsfilLEIIKQGCEF 309
Cdd:cd15067   161 LIFS---SCVSFYIPLVVMLFTYYRIYRAAAK-----EQKAAKTLGIVMGVFILCWLPFFV---------TNILIGFCPS 223
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 310 ENTVHKWI--SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15067   224 NCVSNPDIlfPLVTWLGYINSGMNPIIYACSSRDFR 259
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
74-343 1.90e-17

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 81.64  E-value: 1.90e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYTV 151
Cdd:cd15201     3 LPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRgkHWKFGDIPCRIVLFMLAM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVH---ATNSQRPRKLLAekvVYVGVWIPALLLTI------PDFIFANVSEADDRYICDRF 222
Cdd:cd15201    83 NRAGSIFFLTAVAVDRYFRVVHphhRINSISVRKAAI---IACGLWLLTIAMTVylltkkHLFPRGNATQCESFNICTGT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLW-VVVFQFQhimvgLILPGIVILSCYCIIISKL------SHSKghqKRKALKTTVILILAFFACWLPYYIgISID 295
Cdd:cd15201   160 DSSSNWhEAMFLLE-----FFLPLAIILYCSVRIIWQLrgrqldRHAK---IKRAVQFIMVVAIVFIICFLPSNV-TRIA 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 296 SFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15201   231 IWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYFSSPSFK 278
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
73-287 2.30e-17

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 81.35  E-value: 2.30e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd15369     2 FVPSVYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSgnDWLFGEAMCRVVTAAFY 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYIC---DRFYPNDL 227
Cdd:cd15369    82 CNMYCSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITtchDVLNEQLL 161
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 228 -WVVVFQFQHI-MVGLILPGIVILSCYCIIISKLSHS----KGHQKRKALKTTVILILAFFACWLP 287
Cdd:cd15369   162 mGYYVYYFSIFsCLFFFVPLIITTVCYVSIIRCLSSSsdvaNSSKKTRALFMAVAVFCVFVICFGP 227
7tmA_TAAR5-like cd15317
trace amine-associated receptor 5 and similar receptors, member of the class A family of ...
83-337 5.70e-17

trace amine-associated receptor 5 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR5, TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified trace amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320440 [Multi-domain]  Cd Length: 290  Bit Score: 80.57  E-value: 5.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  83 LTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVAD-LLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSSVLIL 160
Cdd:cd15317    12 LITVSGNLVVIISISHFKQLHSPTNMLVLSLATADfLLGLCVMPFSMIRTVETcWYFGDLFCKFHTGLDLLLCTTSIFHL 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 161 AFISLDRYLAIVHATnsQRPRKL---LAEKVVYVGvWIPALLLTIPDFIFANVSEADDRYICD-------RFYPNDLWVV 230
Cdd:cd15317    92 CFIAIDRYYAVCDPL--RYPSKItvqVAWRFIAIG-WLVPGIYTFGLIYTGANDEGLEEYSSEiscvggcQLLFNKIWVL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 V-----FQFQHIMVGLILPGIVIL-----------SCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISI 294
Cdd:cd15317   169 LdfltfFIPCLIMIGLYAKIFLVArrqarkiqnmeDKFRSSEENSSKASASRERKAAKTLAIVMGIFLFCWLPYFIDTIV 248
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 295 DSFIllEIIKQGCEFENTVhkWisiteaLAFFHCCLNPILYAF 337
Cdd:cd15317   249 DEYS--NFITPAIVFDAVI--W------LGYFNSAFNPFIYAF 281
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
78-343 6.26e-17

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 79.63  E-value: 6.26e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVAN-WYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15310     7 YCALILAIVFGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVylEVTGGvWNFSRICCDVFVTLDVMMCT 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIV------HATNSQRPRKLlaeKVVYVGVWIPALLLTIPDFIFANVSeaDDRYICDRFYPndlw 228
Cdd:cd15310    87 ASILNLCAISIDRYTAVVmpvhyqHGTGQSSCRRV---SLMITAVWVLAFAVSCPLLFGFNTT--GDPTVCSISNP---- 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 vvVFQFQHIMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPyyigisidsFILLEIIKQGCE 308
Cdd:cd15310   158 --DFVIYSSVVSFYLPFGVTLLVYVRIYVVLL-----REKKATQMLAIVLGAFIVCWLP---------FFLTHILNTHCQ 221
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15310   222 ACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFR 256
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
77-337 6.92e-17

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 79.78  E-value: 6.92e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF--VITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd14964     4 ILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLAslVVLVLFFLLGLTEASSRPQALCYLIYLLWYGANL 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDrfYPNDLWVVVFQF 234
Cdd:cd14964    84 ASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVGKGAIPRYNTLTGS--CYLICTTIYLTW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVGLILPGIVILSCYCIIISKLSHSKGHQKR----------KALKTTVILILAFFACWLPYYigISIDSFILLEIIK 304
Cdd:cd14964   162 GFLLVSFLLPLVAFLVIFSRIVLRLRRRVRAIRSaaslntdknlKATKSLLILVITFLLCWLPFS--IVFILHALVAAGQ 239
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 305 QGCEFENTVhkwisitEALAFFHCCLNPILYAF 337
Cdd:cd14964   240 GLNLLSILA-------NLLAVLASTLNPFIYCL 265
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
76-343 8.54e-17

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 79.31  E-value: 8.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCK---AVHVIYT 150
Cdd:cd15059     6 IVSVVILLI-IVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVgLLIMPFSLVNELmGYWYFGSVWCEiwlALDVLFC 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VnlySSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFI-FANVSEADDRY-ICDrfYPNDLW 228
Cdd:cd15059    85 T---ASIVNLCAISLDRYWSVTQAVEYNLKRTPRRAKAMIAAVWIISAVISLPPLFgWKDEQPWHGAEpQCE--LSDDPG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQfqhIMVGLILPGIVILSCYCIIiskLSHSKGHQKRKALKTTVIlILAFFACWLPYYigisidSFILLEIIKQGCE 308
Cdd:cd15059   160 YVLFS---SIGSFYIPLLIMIIVYARI---YRAAKRKERRFTLVLGVV-MGAFVLCWLPFF------FTYPLVVVCKTCG 226
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 309 FENTVHK---WisiteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15059   227 VPELLFKfffW------LGYCNSALNPVIYTIFNKDFR 258
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
72-345 9.60e-17

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 79.86  E-value: 9.60e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAV-DAVANWYFGNFLCKAVHVIY 149
Cdd:cd15399     1 IVLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVyTLLDEWKFGAVLCHLVPYAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLlaeKVVYVGV-WIPALLLTIPDFIFANVS----EADDRY-ICDRFY 223
Cdd:cd15399    81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKI---SFLIIGLtWAASALLASPLAIFREYSvieiSPDFKIqACSEKW 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PN--DLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSH--SKG-------HQKRKALKTTVILILAFFACWLPYY--- 289
Cdd:cd15399   158 PNgtLNDGTIYSVSMLLIQYVLPLAIISYAYIRIWTKLKNhvSPGggndhyhQRRRKTTKMLVCVVVVFAVSWLPFHafq 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 290 IGISIDSFILleiikqgcefENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15399   238 LASDIDSKVL----------DLKEYKLIyTIFHVIAMCSTFANPLLYGWMNNNYRTA 284
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
72-343 9.91e-17

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 79.61  E-value: 9.91e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLH---LSVADLL-FVITLPFWAVDAV---ANWYFGNFLCKA 144
Cdd:cd15130     1 VLVTAIYLALFVVGTVGNSVTLFTLARKKSLQSLQSTVRYHlgsLALSDLLiLLLAMPVELYNFIwvhHPWAFGDAGCRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 145 VHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQ------RPRKLLAekvvyvGVWIPALLLTIP-DFIFANVSEADDR- 216
Cdd:cd15130    81 YYFLRDACTYATALNVASLSVERYLAICHPFKAKtlmsrsRTKKFIS------AIWLASALLAIPmLFTMGLQNESDDGt 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 217 ----YICDRFYPNDLWVVVFQFqHIMVGLILPGIVILSCYCIIISKLSHSkghqKRKALKTTVILILAFFACWLPYYIGI 292
Cdd:cd15130   155 hpggLVCTPIVDTATLKVVIQV-NTFMSFLFPMLVTSILNTVIANKLVQA----LRRGVLVLRAVVIAFVVCWLPYHVRR 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 293 SIDSFILLEiikQGCEF-ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15130   230 LMFCYISDE---QWTTFlFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
73-337 1.01e-16

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 79.43  E-value: 1.01e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFwAVDAVAN---WYFGNFLCKAVHVIY 149
Cdd:cd15200     2 FLAPVLGIEFVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPF-RIDYYLRnevWRFGATACQVNLFML 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSeadDRYICDRFYPNDLWV 229
Cdd:cd15200    81 SMNRTASIVFLTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIHLLLLDHVQ---SNSTCLSYDHGTDPS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGL--ILPGIVILSCYCIIISKLSH---SKGHQKRKALKTTVILILAFFACWLPyYIGISIDSFILLEIik 304
Cdd:cd15200   158 ASDRWHRILFFLefFLPLGIILFCIFSIILTLKQrklAKQAGPQRAVKVLAVIVLVYTVCFLP-SILFALASLVAFKV-- 234
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 305 QGCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15200   235 SQCRSLDLCTQLFHGSLAFTYLNSALDPVLYCF 267
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
80-346 1.16e-16

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 79.54  E-value: 1.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLP-----FWAVDAvanWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15131     9 LLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPldlyrLWQYRP---WNFGDLLCKLFQFVSESCTY 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVsEADDRyiCDRFYPNDLWVVVFQF 234
Cdd:cd15131    86 STILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGPIFVLVGV-EHENG--TNPIDTNECKATEYAV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QH----IMVGL-----ILPGIVILSCYCIIISKLSHSKG-----------HQKRKALKTTVILILAFFACWLPYYIG--I 292
Cdd:cd15131   163 RSglltIMVWVssvffFLPVFCLTVLYSLIGRKLWRRRRenigpnashrdKNNRQTVKMLAVVVFAFVLCWLPFHVGryL 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 293 SIDSF----ILLEIIKQGCEFENTVhkwisiteaLAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15131   243 FSKSFeagsLEIALISQYCNLVSFV---------LFYLSAAINPILYNIMSKKYRVAA 291
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
77-337 1.54e-16

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 79.43  E-value: 1.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15388     6 VLAIIFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVvaFFQVLPQLVWDITDRFRGPDVLCRLVKYLQVVGMF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGvWIPALLLTIPD-FIFANVSEADDRYIC---------DRFYP 224
Cdd:cd15388    86 ASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCVA-WAISLILSLPQvFIFSKVEVAPGVYECwacfiepwgLKAYV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFqfqhimvglILPGIVILSC--------YCIIISKLSHSKGHQKR-------------------KALKTTVIL 277
Cdd:cd15388   165 TWITLVVF---------VLPTLIITVCqvlifkeiHINIYLKSQIIVAVVKKkqllssrassvaevskamiKTVKMTLVI 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 278 ILAFFACWLPYYIgISIDSFILLEIIKQGCEFentvhkwiSITEALAFFHCCLNPILYAF 337
Cdd:cd15388   236 VLVYVLCWAPFFL-VQLWSVWDPKAPTEGATF--------TILMLLASLNSCTNPWIYMA 286
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
80-343 1.77e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 78.51  E-value: 1.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV--ANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15052     9 LLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVgLLVMPLSILTELfgGVWPLPLVLCLLWVTLDVLFCTAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHA--TNSQRPRKLLAEKVVYvgVWIPALLLTIPDFIFANVSEADdryicdrfYPNDLWVVVFQF 234
Cdd:cd15052    89 IMHLCTISLDRYMAIRYPlrTRRNKSRTTVFLKIAI--VWLISIGISSPIPVLGIIDTTN--------VLNNGTCVLFNP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 QHIMVGLI----LPGIVILSCYCIIISKLshskgHQKRKALKTTVILILAFFACWLPyyigisidsFILLEIIKQGCEF- 309
Cdd:cd15052   159 NFVIYGSIvaffIPLLIMVVTYALTIRLL-----SNEQKASKVLGIVFAVFVICWCP---------FFITNILTGLCEEc 224
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 310 -ENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15052   225 nCRISPWLLSVFVWLGYVSSTINPIIYTIFNKTFR 259
7tmA_TAAR5 cd15318
trace amine-associated receptor 5, member of the class A family of seven-transmembrane G ...
86-337 1.86e-16

trace amine-associated receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 5 is one of the 15 identified amine-activated G protein-coupled receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320441 [Multi-domain]  Cd Length: 282  Bit Score: 78.75  E-value: 1.86e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  86 IVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSSVLILAFI 163
Cdd:cd15318    15 VLGNLFVVVTVSHFKALHTPTNFLLLSLALADMLLGLTvLPFSTIRSVEScWYFGDSFCRLHTCLDTLFCLTSIFHLCFI 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 164 SLDRYLAIVHATnsQRPRKL---LAEKVVYVGVWIPALLLTIpdFIFANVSEADDRYI---------CDRFYpNDLW--- 228
Cdd:cd15318    95 SIDRHCAICDPL--LYPSKFtirVACIFIAAGWLVPTVYTSV--FLYTKAVEEGLAELltsvpcvgsCQLLY-NKLWgwl 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 --VVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS---KGHQKRKALKTTVILILAFFACWLPYYIGISIDSFilLEII 303
Cdd:cd15318   170 nfPVFFIPCLIMIGLYVKIFIVAKRQARAIASLLSDtngASKRERKAAKTLGIAVGVYLLCWLPFTIDTMVDSL--LNFI 247
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 304 KQGCEFENTVhkWisiteaLAFFHCCLNPILYAF 337
Cdd:cd15318   248 TPPLLFDIII--W------FAYFNSACNPLIYVF 273
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
76-337 2.00e-16

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 79.09  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15385     5 AVLAVIFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVvaFFQVLPQLCWDITYRFYGPDFLCRIVKHLQVLGM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNS-QRPRKllAEKVVYVGVWIPALLLTIPD-FIFA--NVSEADDRYIC--DRFYPndl 227
Cdd:cd15385    85 FASTYMLVMMTADRYIAICHPLKTlQQPTK--RSYLMIGSAWALSFILSTPQyFIFSlsEIENGSGVYDCwaNFIVP--- 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGL-ILPGIVILSCY---CIIISKLSHSK-------------------------GHQKRKALKTTVILI 278
Cdd:cd15385   160 WGIKAYITWITISIfVVPVIILLTCYgfiCYNIWRNIKCKtrrglsdnalknillavcvssvktiSRAKIRTVKMTFVIV 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1127774881 279 LAFFACWLPYYIgisidsFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd15385   240 LAYIVCWAPFFT------IQMWSVWDQNFPWDESENTAVTITALLASLNSCCNPWIYMF 292
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
79-343 2.34e-16

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 78.52  E-value: 2.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF--VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15337     8 AIVGILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFsaVNGFPLKTISSFNKkWIWGKVACELYGFAGGIFGFM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVH---ATNSQRPRKLLaekVVYVGVWIPALLLTIPDFIfanvseADDRYICDRFY--------P 224
Cdd:cd15337    88 SITTLAAISIDRYLVIAKpleAMKKMTFKRAF---IMIIIIWLWSLLWSIPPFF------GWGRYVPEGFQtsctfdylS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLILPGIVILSCYCIII---------------------SKLSHSKGHQKRKALKTTVILILAFFA 283
Cdd:cd15337   159 RDLNNRLFILGLFIFGFLCPLLIIIFCYVNIIravrnhekemtqtaksgmgkdTEKNDARKKAEIRIAKVAIILISLFLL 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 284 CWLPYYIgisidsFILLEIIKQgcefentvHKWISITEA-----LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15337   239 SWTPYAV------VALLGQFGP--------AYWITPYVSelpvmFAKASAIYNPIIYALSHPKFR 289
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
78-345 4.04e-16

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 77.94  E-value: 4.04e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15391     7 YQSTIFLSVGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMaLFCMPFTFTQIMlGHWVFPAPMCPIVLYVQLVSVTA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLlaEKVVYVGVWIPALLLTIPDFIFANVS----EADDRYICDRFYPNDL-WVV 230
Cdd:cd15391    87 SVLTNTAIGIDRFFAVIFPLRSRHTKSR--TKCIIASIWAISFSLSSVQLFAGRTQrygqYSEGRVLCGESWPGPDtSRS 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISKLSHSKG-------------HQKRKALKTTVILILAFFACWLPYYIGISIDSF 297
Cdd:cd15391   165 AYTVFVMLLTYIIPLLILTSTYGYVGFRLWNRTApgnadkgrddmqiKSKRKVIKMLVFVVLMFGICWLPLHLFNLVQDF 244
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 298 --ILLEIIKQGCEFENTVHKWISITEALAffhcclNPILYAFLGAKFKTS 345
Cdd:cd15391   245 stVFRNMPQHTTRLIYGACHWIAMSNSFV------NPIIYLFMNDSFRSI 288
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
74-343 4.85e-16

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 77.17  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd15295     3 LLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVgAISIPLYIPYTLTNrWDFGRGLCVFWLVIDYL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQ-RPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV 230
Cdd:cd15295    83 LCTASVYNIVLISYDRYQSVSNAVSYRnQQTATLRIVTQMVAVWVLAFLVHGPAILVSDSWKTEDGECEPEFFSNWYILA 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGLILPGIVILSCYCIIISKLshskghQKRKALKTTVILILAFFACWLPYyigisidsfILLEIIKQGCEfE 310
Cdd:cd15295   163 ITSVLEFLVPVILVAYFNTQIYWSLWKRL------RDRKLAKSLAIILGTFAICWAPY---------SLFTIIRAACE-K 226
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 311 NTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15295   227 HRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFR 259
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
81-345 4.92e-16

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 77.33  E-value: 4.92e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  81 IFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSSVL 158
Cdd:cd15330    10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVsVLVLPMAALYQVLNkWTLGQVTCDLFIALDVLCCTSSIL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAI---VHATNSQRPRKllaEKVVYVGVWIPALLLTIPDFIFANVSEaddryicDRFYPNDLWVVV---F 232
Cdd:cd15330    90 HLCAIALDRYWAItdpIDYVNKRTPRR---AAVLISLTWLIGFSISIPPMLGWRTPE-------DRSDPDACTISKdpgY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHIMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPYYIGISIDSFilleiikqgCEFENT 312
Cdd:cd15330   160 TIYSTFGAFYIPLILMLVLYGRIFKAAA-----RERKTVKTLGIIMGTFILCWLPFFIVALVLPF---------CESTCH 225
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 313 VHKWI-SITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15330   226 MPELLgAIINWLGYSNSLLNPIIYAYFNKDFQSA 259
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
73-343 9.85e-16

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 76.82  E-value: 9.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYS-IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVANWY------FGNFLCKA 144
Cdd:cd15975     1 YINTVLScIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYiVIDIPINVYKLLAQKWpfddssFGVFLCKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 145 VHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFI-FANVS------------ 211
Cdd:cd15975    81 VPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIgFVMVPfeyngeqyrtcm 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 212 -EADDRYICDRFYPNDLWVVVFQFqhiMVGLILPGIVILSCYCiiiSKLSHSKGH----------QKRKALKTTVILILA 280
Cdd:cd15975   161 lNATTKFMNFYVDAKDWWLFGFYF---CVPLACTAIFYTLMTC---EMLNRRKGSlrialsehlkQRREVAKTVFCLVVI 234
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 281 FFACWLPYYIGISIDSFILLEIIKQGCEFEN--TVHKWISITeaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15975   235 FALCWFPLHLSRILKKTVYNENDPRRCELLSflLVMDYISIN--LATMNSCINPIALYFVSKKFK 297
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
79-337 9.95e-16

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 76.73  E-value: 9.95e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFWAVDAVA--NWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15212     8 LAIFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSrpGWLFGDRLCLANGFFNACFGIV 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQ--RPRKLLAekvvYVGVWIPALLLTIPDFIFANVSEaddrYICDRFYPNDLWVV--- 230
Cdd:cd15212    88 STLTMTLISFDRYYAIVRQPQGKigRRRALQL----LAAAWLTALGFSLPWYLLASAPE----YYEKLGFYHCLYVLhsg 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 ------VFQFQHIMVGLILPGIVILSCYCII--ISKLSHSK-------GHQKR-----KALKTTVILILAFFACWLPYYI 290
Cdd:cd15212   160 psrlgaAYSSVLIVLCYLLPFALMCFCHYNIckTVRLSESRvrpvttyAHLLRfysemRTATTVLIMIVFIICCWGPYCL 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1127774881 291 GISIDSFILLEIIKQgcefENTVHKWIsitealAFFHCCLNPILYAF 337
Cdd:cd15212   240 LGLVAAAGGYQFPPL----MDTVAIWM------AWANGAINPLIYAI 276
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
77-343 1.06e-15

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 76.80  E-value: 1.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFWAVDAVANW---------YFGNFLCKAVh 146
Cdd:cd15133     6 TYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLvLLLGMPLELYELWQNYpfllgsggcYFKTFLFETV- 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 147 viytvnLYSSVLILAFISLDRYLAIVH----ATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRF 222
Cdd:cd15133    85 ------CLASILNVTALSVERYIAVVHplaaRTCSTRPRVTRVLGCVWGVSMLCALPNTSLHGIKFLGSGVPASAQCTVR 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPndLWVVVFQFQHIMVGLILPGIVILSCYCIIIS-KLSHSKGHQKRKAL---------------------KTTVILILA 280
Cdd:cd15133   159 KP--QAIYNMIPQHTGHLFFVLPMAVISVLYLLMAlRLARERGLDATGAGskigtrtgqllqhprtraqvtKMLFILVVV 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 281 FFACWLPYYIGISIDSFilleiIKQGCEFENTVHKWISITEALAFF-HCCLNPILYAFLGAKFK 343
Cdd:cd15133   237 FAICWAPFHIDRLMWSF-----ISDWTDNLHEVFQYVHIISGVFFYlSSAVNPILYNLMSTRFR 295
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
72-345 1.12e-15

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 76.76  E-value: 1.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15056     1 VVLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVaVLVMPFGAIELVNNrWIYGETFCLVRTSLD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVhatnsqrpRKLLAEK-------VVYVGVW-IPALLLTIPDFIFANVSEADD--RYIC 219
Cdd:cd15056    81 VLLTTASIMHLCCIALDRYYAIC--------CQPLVYKmtplrvaVMLGGCWvIPTFISFLPIMQGWNHIGIEDliAFNC 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPNDLWVVVFQFQHI--MVGLILPGIVILSCYCIII-----------------------SKLSHSKGHQKRKALKTT 274
Cdd:cd15056   153 ASGSTSCVFMVNKPFAIIcsTVAFYIPALLMVLAYYRIYvaareqahqirslqragssnheaDQHRNSRMRTETKAAKTL 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 275 VILILAFFACWLPYYIGISIDSFILLEIikqgCEFENTVHKWisiteaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15056   233 GIIMGCFCVCWAPFFVTNIVDPFIGYRV----PYLLWTAFLW------LGYINSGLNPFLYAFFNKSFRRA 293
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
74-345 1.48e-15

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 76.22  E-value: 1.48e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVA-NWYFGNFLCKAVHVIYTV 151
Cdd:cd15083     3 LGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDFLMCILnCPLMVISSFSgRWIFGKTGCDMYGFSGGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVH-ATNSQRPRKLLAEKVVyVGVWIPALLLTIPDFIFANvseaddRYI-------CDRFY 223
Cdd:cd15083    83 FGIMSINTLAAIAVDRYLVITRpMKASVRISHRRALIVI-AVVWLYSLLWVLPPLFGWS------RYVleglltsCSFDY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNDLWVV-VFQFQHIMVGLILPGIVILSCYC-IIISKLSHSKG----------------HQKRKA----LKTTVILILAF 281
Cdd:cd15083   156 LSRDDANrSYVICLLIFGFVLPLLIIIYCYSfIFRAVRRHEKAmkemakrfskselsspKARRQAevktAKIALLLVLLF 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 282 FACWLPYYIGISIDSFILLEIIkqgcefenTVHKwISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15083   236 CLAWTPYAVVALIGQFGYLEVL--------TPLA-TAIPAAFAKTSAIYNPVIYAFSHPKFRRA 290
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
72-343 1.65e-15

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 76.41  E-value: 1.65e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15396     1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVYTLMDhWIFGETMCKLTSFVQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHAtnsqRPRKLLAEKVVY--VGVWIPALLLTIPDFIFANVSEA------------DD 215
Cdd:cd15396    81 SVSVSVSIFSLVLIAIERYQLIVNP----RGWKPSASHAYWgiVLIWLFSLMISIPFLIFHQLTDEpfrnlsshsdfyKD 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 216 RYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLS--HSKGHQKR---------KALKTTVI-LILAFFA 283
Cdd:cd15396   157 KVVCIEAWPSETERLIFTTSLLVFQYFVPLGFIFICYLKIFVCLKkrNSKIDRMRenesrlsenKRINTMLIsIVVTFAA 236
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 284 CWLPYYIGISIdsFILLEIIKQGCEFeNTVhkwISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15396   237 CWLPLNIFNVV--FDWNHEVLMSCHH-NLV---FTLCHLVAMVSTCINPIFYGFLNKNFQ 290
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
74-343 1.93e-15

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 76.04  E-value: 1.93e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTdKYRLHLSVADLLFVITLPFWAVD--AVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15149     3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNKSFI-VYLKNIVFADLLMSLTFPFKILSdvELGPWQLNVIVCRYSAVIFYL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVV 231
Cdd:cd15149    82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNIILTNQSFHEANYTKCARLKSELGIQW 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQF-QHIMVGLILPGIVILSCYCIIISKL---SHSKGHQ-----KRKALKTTVILILAFFACWLPYYIgISIDSFILLEI 302
Cdd:cd15149   162 HKAsNYICVSIFWVVFLLLIIFYVAISRKiykSNQKFRRnstnmKAKSSRNIFSILFVFFVCFVPYHA-LRIPYTLSQTG 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15149   241 ADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFR 281
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
76-339 2.07e-15

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 75.55  E-value: 2.07e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVIlvMGYQKKLRSMTDK---YRLHLSVADLLFVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd14983     5 MVYVLTILLGLPSNLLAL--YAFVNRARLRLTPnviYMINLCLSDLVFILSLPIKIVEALSSaWTLPAVLCPLYNLAHFS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPA-------LLLTIPDFIFANVSEADDRYIC-DRFY 223
Cdd:cd14983    83 TLYASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVifhvtlvFILETSGGTLDINTPVGNSSTCyENFT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNDLWVVV-FQFQHIMVGLILPGIVILSCY--CIII---SKLSHSKghqKRKALKTTVILILAFFACWLPYYIgisidSF 297
Cdd:cd14983   163 PEQLALLApVRLELSLVLFFLPLAITAFCYvrCIRIlvrSRLHERR---KRRAVRVAVSTLLTFVVCFGPYNI-----SH 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 298 ILLEIIKQGCEFEntvhKWISITEALAFFhccLNPILYAFLG 339
Cdd:cd14983   235 VVGFVRHESVWWR----KLALLTSTCNAF---LDPLIFYFLS 269
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
78-345 2.17e-15

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 75.50  E-value: 2.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI-----TLPFWaVDAVANWYFGNFLCkaVHVIYTVN 152
Cdd:cd14995     7 VLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVaaglpNEIES-LLGPDSWIYGYAGC--LLITYLQY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 L---YSSVLILAFiSLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA----DDRYICDRFYPN 225
Cdd:cd14995    84 LginASSLSITAF-TIERYIAICHPMKAQFICTVSRAKKIICFVWIFTSLYCSPWLFLLDLSIKhygdDIVVRCGYKVSR 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFqfqhiMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKq 305
Cdd:cd14995   163 HYYLPIY-----LADFVLFYVIPLLLAIVLYGLIGRILFSSRKQVTKMLAVVVVLFALLWMPYRTLVVYNSFASPPYLD- 236
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 306 gcefentvhKW-ISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14995   237 ---------LWfLLFCRTCIYLNSAINPILYNLMSQKFRAA 268
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
72-343 2.25e-15

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 75.59  E-value: 2.25e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHVIY 149
Cdd:cd15151     1 VVFPVLYTVLFLVGLILNSVAAWIF-FHIPSTSTFIVYLKNTLVADLIMTLMLPFKILsdSGLGPWQLRAFVCRFSAVVF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFAN-VSEADDRYICDRFY-PNDL 227
Cdd:cd15151    80 YITMYISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNkPATPISVKKCASLKsPLGL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 W---VVVFQFQHIMVGLIlpgIVILSCYCIIISKL------SHSKGHQKRKALKTTVILILA-FFACWLPYYIgISIDSF 297
Cdd:cd15151   160 KwheVVNYICQFIFWGVF---ALMVLFYTIISKKVyesykkSRSKDNKASKKTKAKVFIIVAvFFVCFAPFHF-VRVPYT 235
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 298 ILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15151   236 LSQTGKITDCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFR 281
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
78-343 2.54e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 75.69  E-value: 2.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVD-AVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15980     7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDnIIAGWPFGSTVCKMSGMVQGISVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANVSEADDR-------------YICDRF 222
Cdd:cd15980    87 SVFTLVAIAVDRFRCIVYPFKQKLTIS--TAVVIIVIIWVLAIAIMCPSAVMLHVQEEKNYrvvlgsqnktspvYWCRED 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPN-------------DLWVVVFQFQHIMVGLIlpGIVILSCYCIIISKLSHSKGH----QKRKALKTTVILILAFFACW 285
Cdd:cd15980   165 WPNqemrkiyttvlfaNIYLAPLSLIVIMYARI--GITLFKTAMPHTGKHNQEQRHvvsrKKQKVIKMLLIVALLFILSW 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1127774881 286 LPYYIGISIDSFILLEIIKQgcefeNTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15980   243 LPLWTLMMLSDYANLSPNQL-----QIINIYIyPFAHWLAFFNSSVNPIIYGFFNENFR 296
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
77-343 3.42e-15

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 74.84  E-value: 3.42e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKavhVIYTVNLY 154
Cdd:cd15063     6 VLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVgTLVLPFSAVNEVLDvWIFGHTWCQ---IWLAVDVW 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 ---SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFAN-VSEADDRYICDRFYP------ 224
Cdd:cd15063    83 mctASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNdGKDGIMDYSGSSSLPctcelt 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQfqhIMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIgisidsFILLEIIK 304
Cdd:cd15063   163 NGRGYVIYS---ALGSFYIPMLVMLFFYFRI-----YRAARMETKAAKTVAIIVGCFIFCWLPFFT------VYLVRAFC 228
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 305 QGCeFENTVhkwISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15063   229 EDC-IPPLL---FSVFFWLGYCNSALNPCIYALFSRDFR 263
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
76-343 4.83e-15

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 74.57  E-value: 4.83e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPF-WAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15321    11 AAITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVaTLIIPFsLANELMGYWYFRKTWCEIYLALDVLFC 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHAT--NSQR-PRKLlaeKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVV 230
Cdd:cd15321    91 TSSIVHLCAISLDRYWSVSRAIeyNSKRtPRRI---KCIILIVWLIAAVISLPPLIYKGKQKDEQGGLPQCKLNEEAWYI 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQfqhIMVGLILPGIVILSCYCIIISKlshSKGHQKRKALKTTVIlILAFFACWLPYYIgisidSFILLEIIKQGCEFE 310
Cdd:cd15321   168 LSS---SIGSFFAPCLIMILVYLRIYLI---AKNREKRFTFVLAVV-IGVFVLCWFPFFF-----SYSLGAICPELCKVP 235
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 311 NTVHK---WIsitealAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15321   236 HSLFQfffWI------GYCNSSLNPVIYTIFNQDFR 265
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
73-343 4.88e-15

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 74.94  E-value: 4.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYS-IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV-ITLPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd15977     1 YVNTILScVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLLYIlIAIPINVIKLIAeDWPFGVHVCKLYPFIQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDR----YIC------ 219
Cdd:cd15977    81 KASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRgqtlLVCmlpmeq 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 ----DRFYPN--DLWVVVFQFqhiMVGLILPGIVILSCYCIIISKLS--------HSKghQKRKALKTTVILILAFFACW 285
Cdd:cd15977   161 tssfMRFYQDvkDWWLFGFYF---CLPLACTGVFYTLMSCEMLSIKNgmrialndHMK--QRREVAKTVFCLVVIFALCW 235
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 286 LPYYIGISIDSFILLEIIKQGCEFEN--TVHKWISITeaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15977   236 LPLHLSRILKKTIYDVKDPQRCELLSflLVMDYTGIN--MASLNSCINPVALYFVSRKFK 293
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
72-345 5.63e-15

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 74.06  E-value: 5.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPfwaVDAVANWYFGNFL-CKAVHVI-Y 149
Cdd:cd15163     1 LALMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLP---TRIVMYYSAGNCLtCSFVHIFsY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPA------LLLTIPDFIFANVSEADDRYICDRFY 223
Cdd:cd15163    78 FVNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAivvtfsILTTAIKFASCCLSKLFALTVFEFFL 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PndLWVVVFQFQHIMVGLILPGivilscyciiiskLSHSKGHQKRKALKTTVILILAFFACWLPYYIgisidSFILLEII 303
Cdd:cd15163   158 P--LLIITFFTIRIMCALSRPG-------------LMHQSRERRMRAVQLLITVLIIFMICFTPFHV-----RQVAVAFN 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 304 KQGCEFENTVHKWISITeaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15163   218 PDIPHHTSLIVYHVTVT--LSSLNSCMDPIVYCFVTNNFQST 257
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
72-343 5.79e-15

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 74.62  E-value: 5.79e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITL-PFWAVDAVAN-WYFGNFLCkavhVIY 149
Cdd:cd15074     1 IIIGIYLTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGISVFGyPLAIISAFAHrWLFGDIGC----VFY 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLY----SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVyVGVWIPALLLTIP-------------------DFI 206
Cdd:cd15074    77 GFCGFlfgcCSINTLTAISIYRYLKICHPPYGPKLSRRHVCIVI-VAIWLYALFWAVAplvgwgsygpepfgtscsiDWT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 207 FANVSEADDRYIcdrfypndlwVVVFQFqhimvGLILPGIVILSCYCIIISKLSHSK-------GHQK------RKALKT 273
Cdd:cd15074   156 GASASVGGMSYI----------ISIFIF-----CYLLPVLIIVFSYVKIIRKVKSSRkrvagfdSRSKrqhkieRKVTKV 220
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 274 TVILILAFFACWLPYYIGISIDSFILLEIIKqgcefentvhkwISITEALAFF---HCCLNPILYAFLGAKFK 343
Cdd:cd15074   221 AVLICAGFLIAWTPYAVVSMWSAFGSPDSVP------------ILASILPALFaksSCMYNPIIYLLFSSKFR 281
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
80-343 6.19e-15

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 74.10  E-value: 6.19e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15308     9 LLILAIIAGNVLVCLSVCTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGgvWTLSPVLCDALMTMDVMLCTAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICdRFYPNDLwvVVFQfqh 236
Cdd:cd15308    89 IFNLCAISVDRFIAVSVPLNYNRRQGSVRQLLLISATWILSFAVASPVIFGLNNVPNRDPAVC-KLEDNNY--VVYS--- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 237 IMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPYYIgisidsfilLEIIKQGCEFENTVHKW 316
Cdd:cd15308   163 SVCSFFIPCPVMLVLYCAMFRGLG-----RERKAMRVLPVVVGAFLFCWTPFFV---------VHITRALCESCSIPPQL 228
                         250       260
                  ....*....|....*....|....*..
gi 1127774881 317 ISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15308   229 ISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
72-344 8.66e-15

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 73.45  E-value: 8.66e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIY 149
Cdd:cd15210     1 YFAAVWGIVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFcAFNLPLAASTFLhQAWIHGETLCRVFPLLR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPD-----FIFANVSEADDRYICDRFYP 224
Cdd:cd15210    81 YGLVAVSLLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLPLwlgiwGRFGLDPKVCSCSILRDKKG 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFqhimvGLILPGIVILSCYCIiisklshskgHQKRKALKTTVILILAFFACWLPYYIGISIDSfilleiik 304
Cdd:cd15210   161 RSPKTFLFVF-----GFVLPCLVIIICYAR----------REDRRLTRMMLVIFLCFLVCYLPITLVNVFDD-------- 217
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 305 qgcefeNTVHKWISITEA-LAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15210   218 ------EVAPPVLHIIAYvLIWLSSCINPIIYVAMNRQYRQ 252
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
78-343 9.54e-15

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 74.08  E-value: 9.54e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15395     7 YSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMTIMcLPFTFVYTLMDhWVFGEAMCKLNSMVQCISITV 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHAtNSQRPRKllaeKVVYVGV---WIPALLLTIPDFIFANVSEA------------DDRYICD 220
Cdd:cd15395    87 SIFSLVLIAIERHQLIINP-RGWRPNN----RHAYVGIaviWVLAVLTSLPFLIFQVLTDEpfknvnvsldayKGKYVCL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 221 RFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL------------SHSKGHQKRKALKTTVILILAFFACWLPY 288
Cdd:cd15395   162 DQFPSDTIRLSYTTCLLVLQYFGPLCFIFICYLKIYIRLkrrnnmmdkmrdNKYRSSETKRINIMLISIVVAFAVCWLPL 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 289 yigisidsFILLEIIKQGCEFENTVHK--WISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15395   242 --------NIFNAVFDWNHEAIATCNHnlLFLICHLTAMISTCVNPIFYGFLNKNFQ 290
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
72-343 1.24e-14

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 73.24  E-value: 1.24e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN--WYFGNFLCKA-VHV 147
Cdd:cd15302     1 ILLALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGdyWPLGWVLCDLwLSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILaFISLDRYLAIVHAT---NSQRPRKLLaekVVYVGVW-IPALLLTIPDFIFANVSeADDRYICD--- 220
Cdd:cd15302    81 DYTVCLVSIYTVL-LITIDRYCSVKIPAkyrNWRTPRKVL---LIIAITWiIPALLFFISIFGWQYFT-GQGRSLPEgec 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 221 --RFYPNDLWVVVFQFQHIMVGLilpgIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFi 298
Cdd:cd15302   156 yvQFMTDPYFNMGMYIGYYWTTL----IVMLILYAGI-----YRAANRARKALRTITFILGAFVICWTPYHILATIYGF- 225
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 299 lleiikqgCEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15302   226 --------CEAPPCVNETLyTISYYLCYMNSPINPFCYALANQQFK 263
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
74-343 1.41e-14

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 72.85  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTV 151
Cdd:cd15050     3 LGIALSTISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLESkWILGRPVCLFWLSMDYV 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDF---IFANVSEADDRYI-CDRFYPNDL 227
Cdd:cd15050    83 ASTASIFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwhHFARGGERVVLEDkCETDFHDVT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQfqhIMVGLILPGIVILSCYCIIISKLshskgHQKRKALKTTVILILAFFACWLPYYIgisidSFILLEIIKQGC 307
Cdd:cd15050   163 WFKVLT---AILNFYIPSLLMLWFYAKIFKAV-----NRERKAAKQLGFIMAAFILCWIPYFI-----LFMVIAFCKNCC 229
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 308 efENTVHKwisITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15050   230 --NENLHM---FTIWLGYINSTLNPFIYPLCNENFK 260
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
77-343 2.01e-14

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 73.34  E-value: 2.01e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHL---SVADLL-FVITLPFWAVDAV---ANWYFGNFLCKAVHVIY 149
Cdd:cd15355     6 IYLALFVVGTVGNSITLYTLARKKSLQHLQSTVHYHLaslALSDLLiLLLAMPVELYNFIwvhHPWAFGDAACRGYYFLR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPdFIFA----NVSEAD-DRYICDRFYP 224
Cdd:cd15355    86 DACTYATALNVASLSVERYLAICHPFKAKSLMSRSRTKKFISAIWLASALLAIP-MLFTmgeqNRSGTHpGGLICTPIVD 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMvGLILPGIVILSCYCIIISKL-----------------------SHSKGHQKRKALKTTV----IL 277
Cdd:cd15355   165 TSTLKVVIQVNAFL-SFLFPMLVISVLNTLIANQLtvmvnqaeqenqvctiggqrtvlSVSMEPGRVQSLRHGVlvlrAV 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 278 ILAFFACWLPYYIGISIDSFILLEiiKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15355   244 VIAFVVCWLPYHVRRLMFCYVSDE--QWTTFLYDFYHYFYMLTNVLFYVSSAINPILYNLVSANFR 307
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
77-297 2.13e-14

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 73.25  E-value: 2.13e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15058     6 LLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGATIVVTgKWQLGNFWCELWTSVDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIvhaTNSQRPRKLLAE---KVVYVGVWI-PALLLTIP---DFIFANVSEADDRY----ICDrFY 223
Cdd:cd15058    86 ASIETLCVIAVDRYIAI---TRPLRYQVLLTKrraRVIVCVVWIvSALVSFVPimnQWWRANDPEANDCYqdptCCD-FR 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PND--------------------LWVVVFQFQHIMVGLI----------LPGIVILSCYCIIISKLSHSKGHQKR--KAL 271
Cdd:cd15058   162 TNMayaiassvvsfyipllimifVYARVFLIATRQLQLIdkrrlrfqseCPAPQTTSPEGKRSSGRRPSRLTVVKehKAL 241
                         250       260
                  ....*....|....*....|....*.
gi 1127774881 272 KTTVILILAFFACWLPYYIGISIDSF 297
Cdd:cd15058   242 KTLGIIMGTFTLCWLPFFIANIINVF 267
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
77-342 2.21e-14

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 72.91  E-value: 2.21e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL---LFVItLPFWAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15386     6 VLAAILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLvvaLFQV-LPQLIWEITYRFQGPDLLCRAVKYLQVLSM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNS-QRPRKllaEKVVYVGV-WIPALLLTIPD-FIFA--NVSEADDRYICdrfypndlW 228
Cdd:cd15386    85 FASTYMLIMMTVDRYIAVCHPLRTlQQPSR---QAYLMIGAtWLLSCILSLPQvFIFSlrEVDQGSGVLDC--------W 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 vVVFQFQ---------HIMVGLILPGIVILSCYCIIISKLSH-----------SKGHQ------------------KRKA 270
Cdd:cd15386   154 -ADFGFPwgakayitwTTLSIFVLPVAILIVCYSLICYEICKnlkgktqtsrsEGGGWrtqgmpsrvssvrtisraKIRT 232
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 271 LKTTVILILAFFACWLPYYigisidSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd15386   233 VKMTFVIVLAYIACWAPFF------SVQMWSVWDENAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFSGHL 298
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
72-345 2.25e-14

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 72.91  E-value: 2.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHVIY 149
Cdd:cd14996     1 VALPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAyfLKGFYWKYQSTQCRIANFFG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 T----VNLYSSVLILAFISLDRYLAIVHATNSQR---------PRKLLAE-------KVVYVGVWIPALLLTIPDFIFAN 209
Cdd:cd14996    81 TlvihVSMCVSILILSWIAISRYATLMKHDSATQkqscyekifYGHFLKRfrqpkfaRYLCIYIWGVVLCIIIPVVVYYS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 210 VSEADDRYicDRFYPNDLWVVVFQFQHI--MVGLILPG---IVILSCYCIIISKLSHSKGHQ--------KRKALKTTVI 276
Cdd:cd14996   161 VREADEDG--ESLCYNRQVELGAKGSQIagLIATTFFFlffLVVLLSYYSFVNHLRRIQKNTcisekdliYRSVKRNILI 238
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1127774881 277 LILAFFACWLPYYIGISIdsFILLeIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd14996   239 IQALLVVCFLPYHIFKPV--FYVL-HQREDCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFKKT 304
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
80-343 2.46e-14

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 72.66  E-value: 2.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRL-HLSVADLLFVITLpfwAVDAVANWYFGNF------------LCKAVH 146
Cdd:cd14980     9 IIGILALIGNILVIIWHISSKKKKKKVPKLLIiNLAIADFLMGIYL---LIIAIADQYYRGRyaqyseewlrspPCLLAC 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 147 VIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIFANVSEADDR-----YICdr 221
Cdd:cd14980    86 FLVSLSSLMSVLMMLLITLDRYICIVYPFSNKRLSYKSA-KIILILGWLFSIIFAAIPILYSINQPGDNRlygysSIC-- 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 fYPNDL-------WVVvfqfqhIMVGL-ILPGIVILSCY-CIIIS-----KLSHSKGHQKRKALKTTVILILAF-FACWL 286
Cdd:cd14980   163 -MPSNVsnpyyrgWLI------AYLLLtFIAWIIICILYiLIFISvrksrKSARRSSSKRDKRIAIRLALILITdLICWL 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 287 PYYIgISIDSFIlleiikQGCEFENTVHKWISIteaLAF-FHCCLNPILYAFLGAKFK 343
Cdd:cd14980   236 PYYI-VIFSGLL------TSTEIDIHVLQFIAI---LALpLNSAINPYLYTLTTPTFK 283
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
72-343 3.10e-14

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 72.12  E-value: 3.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIY 149
Cdd:cd15209     1 SALACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHngWTLGQLHCQASGFIM 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFiFANVSEADDR-YICDRFYPND-- 226
Cdd:cd15209    81 GLSVIGSIFNITAIAINRYCYICHSLQYDRLYSLRNTCCYLCLTWLLTVLAVLPNF-FIGSLQYDPRiYSCTFAQTVStv 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 --LWVVVFQFqhimvglILPGIVILSCYC---IIISKLSHSKGHQKRKALK--------TTVILILAFFACWLPYyigis 293
Cdd:cd15209   160 ytITVVVIHF-------LLPLLIVSFCYLriwVLVLQVRQRVKPDQRPKLKpadvrnflTMFVVFVLFAVCWAPL----- 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 294 idSFILLEIIKQGCEFENTVHKWISITEA-LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15209   228 --NFIGLAVAINPKEMAPKIPEWLFVASYfMAYFNSCLNAIIYGLLNQNFR 276
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
78-343 3.60e-14

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 72.55  E-value: 3.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  78 YSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVD-AVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15981     7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDnLITGWPFDNAMCKMSGLVQGMSVSA 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATnsQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICD---RFYP-------- 224
Cdd:cd15981    87 SVFTLVAIAVERFRCIVHPF--RQKLTLRKAIVTIVIIWVLALIIMCPSAVTLTVTREEHHFMVDdynNSYPlyscweaw 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 -----NDLWVVVFqFQHIMVGlilPGIVILSCYCIIISKLSHSKG----------------HQKRKALKTTVILILAFFA 283
Cdd:cd15981   165 pdtemRKIYTTVL-FSHIYLA---PLTLIVIMYARIAFKLFKSSApirgsqgeeeegrrvsKRKIKVINMLIIVALFFTL 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 284 CWLPYYigisidSFILLEIIKQGCEFE-NTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15981   241 SWLPLW------TLMLLTDYGHLSEDQlNLVTVYVfPFAHWLAFFNSSVNPIIYGYFNENFR 296
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
72-335 4.53e-14

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 71.62  E-value: 4.53e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd15331     1 VLTSIILGLLILATIIGNVFVIAAILLERSLQGVSNYLILSLAVADLMVaVLVMPLSAVYEVSqHWFLGPEVCDMWISMD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHAT--NSQRPRKLLaekVVYVGVWIPALLLTI-PDFIFANVSEADDRYICDRFYPN- 225
Cdd:cd15331    81 VLCCTASILHLVAIALDRYWAVTNIDyiRRRTAKRIL---IMIAVVWFVSLIISIaPLFGWKDEDDLDRVLKTGVCLISq 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQfqhiMVG-LILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPyyigisidsFILLEIIK 304
Cdd:cd15331   158 DYGYTIFS----TVGaFYVPLLLMIIIYWKI-----YQAAKRERKAARTLAIITGAFVVCWLP---------FFLVALVM 219
                         250       260       270
                  ....*....|....*....|....*....|.
gi 1127774881 305 QGCEFENTVHKWISITEALAFFHCCLNPILY 335
Cdd:cd15331   220 PFCGAWQISRFLESFFLWLGYFNSLLNPIIY 250
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
72-345 5.38e-14

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 71.52  E-value: 5.38e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15299     4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTVNNYFLLSLACADLIIgVISMNLFTTYIIMNrWALGNLACDLWLSID 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15299    84 YVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPDECFIQFLSE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFilleiikqgCEF 309
Cdd:cd15299   164 PIITFGTAIAAFYLPVTIMTILYWRI-----YKETIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTF---------CDS 229
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 310 ENTVHKWiSITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15299   230 CIPKTYW-NLGYWLCYINSTVNPVCYALCNKTFRTT 264
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
72-343 6.67e-14

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 71.36  E-value: 6.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL---FVITLPFWAVdAVANWYFGNFLCKAVHVI 148
Cdd:cd15296     1 VILAVLMALLVVATVLGNALVILAFVVDSSLRTQGNFFFLNLAISDFLvggFCIPLYIPYV-LTGRWKFGRGLCKLWLVV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATnSQRPRKLLAEKVV--YVGVWIPALLLTIPDFIF----ANVSEADDRYICDRF 222
Cdd:cd15296    80 DYLLCTASVFNIVLISYDRFLSVTRAV-SYRAQKGMTRQAVlkMVLVWVLAFLLYGPAIISweyiAGGSIIPEGECYAEF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQHIMVGLILPGIVILSCYcIIISKLSHSKGHQKRKAlKTTVILILAFFACWLPYyigisidsfILLEI 302
Cdd:cd15296   159 FYNWYFLMTASTLEFFTPFISVTYFNLSIY-LNIQKRRFRLSRDKKVA-KSLAIIVCVFGLCWAPY---------TLLMI 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15296   228 IRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFR 268
CXCR4_N pfam12109
CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. ...
39-71 9.12e-14

CXCR4 Chemokine receptor N terminal; CXCR4 and its ligand stromal cell-derived factor-1 (a.k.a. CXCL12) are essential for proper fetal development. CXCR4 is also the major coreceptor for T-tropic strains of human immunodeficiency virus 1 (HIV-1), and SDF-1 inhibits HIV-1 infection. Additionally, SDF-1 and CXCR4 mediate cancer cell migration and metastasis. The N terminal domain of most chemokine receptors is the ligand binding domain and so the N terminal domain of CXCR4 is the binding site for SDF-1.


Pssm-ID: 432337  Cd Length: 33  Bit Score: 64.80  E-value: 9.12e-14
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1127774881  39 IYTSDNYTEEMGSGDYDSMKEPCFREENANFNK 71
Cdd:pfam12109   1 IEFSDNNTEEIGSGDYGDYKEPCFQHENADFNR 33
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
77-345 9.65e-14

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 70.67  E-value: 9.65e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPF-WAVDAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15324     6 VVVVIILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFsLANEVMGYWYFGSTWCAFYLALDVLFCT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADdryiCdrFYPNDLWVVVFQf 234
Cdd:cd15324    86 SSIVHLCAISLDRYWSVTKAVSYNLKRTPKRIKRMIAVVWVISAVISFPPLLMTKHDEWE----C--LLNDETWYILSS- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 qhIMVGLILPGIVILSCYCIIISKlshSKGHQKRKALKTTVIlILAFFACWLPYYIGISIDSfilleIIKQGCEFENTVH 314
Cdd:cd15324   159 --CTVSFFAPGLIMILVYCKIYRV---AKMREKRFTFVLAVV-MGVFVLCWFPFFFTYSLHA-----VCRKRCGIPDALF 227
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1127774881 315 K---WIsitealAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15324   228 NlffWI------GYCNSSVNPIIYTIFNRDFRKA 255
7tmA_Glyco_hormone_R cd15136
glycoprotein hormone receptors, member of the class A family of seven-transmembrane G ...
80-343 9.70e-14

glycoprotein hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors (GPHRs) are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG) and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. GPHRs couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein.


Pssm-ID: 320264 [Multi-domain]  Cd Length: 275  Bit Score: 70.71  E-value: 9.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWA-VDA---------VANWYFGNfLCKAVHVIY 149
Cdd:cd15136     9 FVFLLALVGNIIVLLVLLTSRTKLTVPRFLMCNLAFADFCMGIYLGLLAiVDAktlgeyynyAIDWQTGA-GCKTAGFLA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLL-TIPDFifaNVSEADDRYIC---DRFYPN 225
Cdd:cd15136    88 VFSSELSVFTLTVITLERWYAITHAMHLNKRLSLRQAAIIMLGGWIFALIMaLLPLV---GVSSYSKTSIClpfETETPV 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFqfqhIMVGLILPGIVILSCYCIIISKLSHS---KGHQKRKALKTTVILILAFFACWLPyyigisIDSFILLEI 302
Cdd:cd15136   165 SKAYVIF----LLLFNGLAFLIICGCYIKIYLSVRGSgraANSNDTRIAKRMALLVFTDFLCWAP------IAFFGLTAA 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1127774881 303 IKqgcefentvHKWISITEA---LAFF---HCCLNPILYAFLGAKFK 343
Cdd:cd15136   235 FG---------LPLISVSNAkilLVFFyplNSCANPFLYAIFTKQFR 272
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
72-343 1.26e-13

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 70.04  E-value: 1.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVI- 148
Cdd:cd15049     1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTVNNYFLLSLACADLIIgLVSMNLYTVYLVMGyWPLGPLLCDLWLALd 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLySSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIF-------ANVsEADDRYIcdR 221
Cdd:cd15049    81 YVASN-ASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILGwqyfvgeRTV-PDGQCYI--Q 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNdlwvVVFQFQHIMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPYYIgisidsfilLE 301
Cdd:cd15049   157 FLDD----PAITFGTAIAAFYLPVLVMTILYWRIYRETA-----RERKAARTLSAILLAFIITWTPYNI---------LV 218
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1127774881 302 IIKQGCEFENTVHKWisiteALAFFHC----CLNPILYAFLGAKFK 343
Cdd:cd15049   219 LVSTFCAKCIPDTLW-----SFGYWLCyinsTINPFCYALCNKTFR 259
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
72-345 1.38e-13

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 70.65  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVAD-LLFVITLPFWAVD-AVANWYFGNFLCKAVHVIY 149
Cdd:cd15403     1 ILLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDiMLSLLCMPFTAVTiITVDWHFGAHFCRISAMLY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllaEKVVYVGVWIPALLLTIPDFIFANVSEADDR----------YIC 219
Cdd:cd15403    81 WFFVLEGVAILLIISVDRFLIIVQRQDKLNPHR---AKVMIAISWVLSFCISFPSVVGWTLVEVPARapqcvlgyteSPA 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPNDLWVVVFqfqhimvgLILPGIVILSCYCII---------------------ISKLS---HSKGHQ-------KR 268
Cdd:cd15403   158 DRVYAVLLVVAVF--------FVPFSIMLYSYLCILntvrrnavrihnhadslclsqVSKLGlmgLQRPHQmnvdmsfKT 229
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 269 KALKTTVILILAFFACWLPYYIgisidsFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15403   230 RAFTTILILFVGFSLCWLPHTV------FSLLSVFSRRFYYSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFREA 300
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
45-344 2.04e-13

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 71.00  E-value: 2.04e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  45 YTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVIL-------VMGYQKKLRSMTDKYrlhlsVAD 117
Cdd:PHA03235    6 HNETNDENDLLHVNDTCVPTEGLSAARTTETFINLLIISVGGPLNLIVLVtqllanrVHGFSTPTLYMTNLY-----LAN 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 118 LLFVITLPFWAVdavANWYF--GNFL-CKAVHVIYTVNLYSSVLILAFISLDRYlAIVHATNSQRPRKLLAEKVVYVGVW 194
Cdd:PHA03235   81 LLTVFVLPFIML---SNQGLlsGSVAgCKFASLLYYASCTVGFATVALIAADRY-RVIHQRTRARSSAYRSTYKILGLTW 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 195 IPALLLTIPDFIFANVSEADDRYICDRFYpnDLWVVVFQFQHI------------MVGLILPGIVILSCYCIIISKLSHS 262
Cdd:PHA03235  157 FASLICSGPAPVYTTVVAHDDVDPEAPGY--ETCVIYFRADQVktvlstfkvlltLVWGIAPVVMMTWFYTFFYRTLKRA 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 263 KGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLeIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:PHA03235  235 SYKKRSRTLTFVCILLLSFLCLQTPFVAIMIFDSYATL-IWPSDCEHINLRDAVSTLSRLVPNLHCLLNPILYAFLGNDF 313

                  ..
gi 1127774881 343 KT 344
Cdd:PHA03235  314 LK 315
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
72-347 2.36e-13

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 69.59  E-value: 2.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIY 149
Cdd:cd15334     1 ILISLTLSILALMTTAINSLVITAIIVTRKLHHPANYLICSLAVTDFLVaVLVMPFSIMYIVKeTWIMGQVVCDIWLSVD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA-DDRYICDRFYpndlw 228
Cdd:cd15334    81 ITCCTCSILHLSAIALDRYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSrEDECIIKHDH----- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 vVVFQFQHIMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGisidsfillEIIKQGCE 308
Cdd:cd15334   156 -IVFTIYSTFGAFYIPLALILILYYKI-----YRAATRERKAATTLGLILGAFVICWLPFFVK---------EVIVNTCD 220
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 309 FENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQ 347
Cdd:cd15334   221 SCYISEEMSNFLTWLGYINSLINPLIYTIFNEDFKKAFQ 259
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
73-343 3.62e-13

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 69.47  E-value: 3.62e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYS-IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NW-----YFGNFLCKA 144
Cdd:cd15128     1 YINTVVScLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDLLYiVIDLPINVYKLLAmDWpfgdqPFGQFLCKL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 145 VHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEAD----DRYIC- 219
Cdd:cd15128    81 VPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNykgvTLRTCl 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 -------DRFYPN--DLWVVVFQFqhiMVGLILPGI--VILSCyciiiSKLSHSKG----------HQKRKALKTTVILI 278
Cdd:cd15128   161 lrpetsfMKFYIDvkDWWLFGFYF---CLPLVCTAIfyTLMTC-----EMLRKRNGmlrialnehlKQRREVAKTVFCLV 232
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 279 LAFFACWLPYYIGISIDSFILLEIIKQGCEFEN--TVHKWISITeaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15128   233 VIFALCWLPLHLSRILKLTVYDQNDPNRCELLSflLVLDYFGIN--LATLNSCINPIALYFVSRKFK 297
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
77-343 4.01e-13

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 69.08  E-value: 4.01e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAV-DAVANWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15301     6 VAAVLSLVTVGGNVMVMISFKIDKQLQTISNYFLFSLAVADFAIgVISMPLFTVyTALGYWPLGYEVCDTWLAIDYLASN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATnSQRPRKLLAEKVVYVG-VWIPALLLTiPDFIFANvseaddRYICDRFY-PNDLWVVVF 232
Cdd:cd15301    86 ASVLNLLIISFDRYFSVTRPL-TYRARRTTKKAAVMIAsAWIISLLLW-PPWIYSW------PYIEGKRTvPAGTCYIQF 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 --QFQHIMVG-----LILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikq 305
Cdd:cd15301   158 leTNPYVTFGtalaaFYVPVTIMCILYWRIWRETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKAFF------- 230
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 306 gcEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15301   231 --PCSDTIPTELwDFSYYLCYINSTINPLCYALCNAAFR 267
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
76-343 4.77e-13

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 68.74  E-value: 4.77e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLH---LSVADLL-FVITLPFWAVDAV---ANWYFGNFLCKAVHVI 148
Cdd:cd15356     5 AVYALIWALGAAGNALTIHLVLKKRSLRGLQGTVHYHlvsLALSDLLiLLISVPIELYNFVwfhYPWVFGDLVCRGYYFV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP-DFIFANVSEAD--------DRYIC 219
Cdd:cd15356    85 RDICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPmAFIMGQKYELEtadgepepSSRVC 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPNDLWVVVFQFqHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVIlilAFFACWLPYYIGISIDSFIL 299
Cdd:cd15356   165 TVLVSRATLKVFIQV-NAFVSFVLPLALIAFLNGVTVSHLRIQSLQHSVQVLRAIVI---AYVICWLPYHARRLMFCYVP 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 300 LEIIKQgcEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15356   241 DDAWTD--SLYNFYHYFYMLTNTLFYVSSAVNPLLYNVVSSSFR 282
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
73-345 5.55e-13

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 68.64  E-value: 5.55e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVA--NWYFGNFLCKAVHVIYT 150
Cdd:cd15398     2 FLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLldQWIFGEVMCHIVPFLQC 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIF---ANVSEADD------RYICDR 221
Cdd:cd15398    82 VSVMVSTLMLMSIAIVRYHMIKHPLSNHLTAN--HGYFLLGTVWTLGFTICSPLPVFhkiVDLSETFNleslknKYLCIE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQFQHIMVGLILPgiviLSCYCIIISKLSHSKGHQKRKALKTTvILILAFFACWLPYYIGISIDSFille 301
Cdd:cd15398   160 SWPSDSYRIAFTISLLFVQYILP----LVCLTVSHTSVCRSVKRSRSVFYRLT-IVILAFAVSWMPLHLFHLVTDF---- 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 302 iikQGCEFENTVHKWI-SITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15398   231 ---NANLISNRHFKLVyCICHLLGMLSCCLNPILYGFLNNGIKSD 272
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
76-338 6.20e-13

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 68.33  E-value: 6.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNL 153
Cdd:cd15215     4 VLIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLLVADLLqTVLVMPWVIATSVPLfWPLDSHLCTALVVLMHLFA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSqrPRKLLAEK--VVYVGVWIPALLLTIPDFIFANVSEADDRYicdrFYPNDLWVVV 231
Cdd:cd15215    84 FAGVNTIVVVSVDRYLAIIHPLSY--PTKMTPRRgyLLIYGTWIVSVLQSTPPLYGWGQAAFDERN----ALCSVIWGSS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHIMVGL--ILPGIVILSCYCIIISKlshSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikqgcef 309
Cdd:cd15215   158 YSYTILSVVSsfVLPVIIMLACYSMVFRA---ARRCYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWV----------- 223
                         250       260       270
                  ....*....|....*....|....*....|
gi 1127774881 310 ENTVHKW-ISITEALAFFHCCLNPILYAFL 338
Cdd:cd15215   224 DTQVPQWvISIILWLFFLQCCIHPYIYGYM 253
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
80-344 1.29e-12

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 67.67  E-value: 1.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFwAVDAVANWYFGNFLCKAVHVIYTVNLYSSVL 158
Cdd:cd14968     9 LIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPL-AILISLGLPTNFHGCLFMACLVLVLTQSSIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIV------HATNSQRPRKLLAekvvyvGVWIPALLL-TIPDFIFANVSEADDRYICD-------RFYP 224
Cdd:cd14968    88 SLLAIAIDRYLAIKiplrykSLVTGRRAWGAIA------VCWVLSFLVgLTPMFGWNNGAPLESGCGEGgiqclfeEVIP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGH----------QKRKALKTTVILILAFFA-CWLPYYIGIS 293
Cdd:cd14968   162 MDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRKQLRQIESLlrsrrsrstlQKEVKAAKSLAIILFLFAlCWLPLHIINC 241
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 294 IDSFilleiikqgCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd14968   242 ITLF---------CPECKVPKILTYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
80-345 1.47e-12

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 67.26  E-value: 1.47e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN--WYFGNFLCKAvhVIYTVNLYS- 155
Cdd:cd15304     9 IVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLgFLVMPVSMLTILYGyrWPLPSKLCAV--WIYLDVLFSt 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 -SVLILAFISLDRYLAIV----HATNSQRPR---KLLAEKVVYVGVWIPallltIPDFIFANVSEADDRYICdrFYPNDL 227
Cdd:cd15304    87 aSIMHLCAISLDRYIAIRnpihHSRFNSRTKaflKIIAVWTISVGISMP-----IPVFGLQDDSKVFKEGSC--LLADEN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFqhimVGLILPGIVILSCYCIIISKLSHSKGHQKrKALKTTVILILAFFACWLPYYIgisidSFILLEIIKQGC 307
Cdd:cd15304   160 FVLIGSF----VAFFIPLTIMVITYFLTIKSLQQSISNEQ-KASKVLGIVFFLFVVMWCPFFI-----TNVMAVICKESC 229
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1127774881 308 EfENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15304   230 N-EVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYRSA 266
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
72-345 1.82e-12

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 66.91  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIY 149
Cdd:cd15297     1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIgVFSMNLYTLYTViGYWPLGPVVCDLWLALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIF------ANVSEADDRYIcdRFY 223
Cdd:cd15297    81 YVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFwqfivgGRTVPEGECYI--QFF 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNdlwvVVFQFQHIMVGLILPGIVILSCYCIIiSKLSHskghQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleii 303
Cdd:cd15297   159 SN----AAVTFGTAIAAFYLPVIIMTVLYWQI-SRASS----REKKVTRTILAILLAFIITWTPYNVMVLINTFC----- 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1127774881 304 kQGCeFENTVhkWIsITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15297   225 -ASC-IPNTV--WT-IGYWLCYINSTINPACYALCNATFKKT 261
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
77-343 2.69e-12

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 66.47  E-value: 2.69e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIflTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADlLFVITLPFwAVDAVA----NWYFGNFLCKAVHVIYTVN 152
Cdd:cd15401     8 IFTIV--VDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVAD-LVVAVYPY-PLILLAifhnGWTLGNIHCQISGFLMGLS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHatnSQRPRKLLAEK--VVYVGV-WIPALLLTIPDFiFANVSEADDRYICDRFYPN---- 225
Cdd:cd15401    84 VIGSVFNITAIAINRYCYICH---SLRYDKLYNMKktCCYVCLtWVLTLAAIVPNF-FVGSLQYDPRIYSCTFAQTvsss 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 -DLWVVVFQFqhimvglILPGIVILSCYC---IIISKLSHS---------KGHQKRKALKTTVILILaFFACWLPYyigi 292
Cdd:cd15401   160 yTITVVVVHF-------IVPLSIVTFCYLriwVLVIQVKHRvrqdskqklKANDIRNFLTMFVVFVL-FAVCWGPL---- 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 293 sidSFILLEIIKQGCEFENTVHKWISITEA-LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15401   228 ---NFIGLAVAINPLKVAPKIPEWLFVLSYfMAYFNSCLNAVIYGVLNQNFR 276
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
79-343 2.94e-12

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 66.10  E-value: 2.94e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15335     8 ALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVMDtWTLGYFICEIWLSVDMTCCTCS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNdlwvVVFQFQH 236
Cdd:cd15335    88 ILHLCVIALDRYWAITDAIEYARKRTAKRAGLMILTVWTISIFISIPPLFWRNHHDANIPSQCIIQHDH----VIYTIYS 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 237 IMVGLILPGIVILSCYCIIISKLShskghQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENtvhkW 316
Cdd:cd15335   164 TFGAFYIPLTLILILYYRIYHAAS-----RERKAARILGLILGAFILSWLPFFIKELIVGLSVMTVSPEVADFLT----W 234
                         250       260
                  ....*....|....*....|....*..
gi 1127774881 317 isiteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15335   235 ------LGYVNSLVNPLLYTSFNEDFK 255
7tmA_GPR161 cd15214
orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G ...
80-337 3.15e-12

orphan G protein-coupled receptor 161, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR161, an orphan GPCR, is a negative regulator of Sonic hedgehog (Shh) signaling, which promotes the processing of zinc finger protein GLI3 into its transcriptional repressor form (GLI3R) during neural tube development. In the absence of Shh, this proteolytic processing is normally mediated by cAMP-dependent protein kinase A (PKA). GPR161 is recruited to primary cilia by a mechanism depends on TULP3 (tubby-related protein 3) and the intraflagellar complex A (IFT-A). Moreover, Gpr161 knockout mice show phenotypes observed in Tulp3/IFT-A mutants, and cause increased Shh signaling in the neural tube. Taken together, GPR161 negatively regulates the PKA-dependent GLI3 processing in the absence of Shh signal by coupling to G(s) protein, which causes activation of adenylate cyclase, elevated cAMP levels, and activation of PKA. Conversely, in the presence of Shh, GPR161 is removed from the cilia by internalization into the endosomal recycling compartment, leading to downregulation of its activity and thereby allowing Shh signaling to proceed. In addition, GPR161 is over-expressed in triple-negative breast cancer (lacking estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression) and correlates with poor prognosis. Mutations of GPR161 have also been implicated as a novel cause for pituitary stalk interruption syndrome (PSIS), a rare congenital disease of the pituitary gland. GPR161 is a member of the class A family of GPCRs, which contains receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320342 [Multi-domain]  Cd Length: 261  Bit Score: 66.12  E-value: 3.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNgLVILVMGYQKK-LRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15214     8 IIAILICLGN-LVIVVTLYKKSyLLTLSNKFVFSLTLSNLLLsVLVLPFVVTSSIrREWIFGVVWCNFSALLYLLISSAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATnsQRPRKLLAEKVVY--VGVWIPALLLTIPDFIFANVSEADD-RYICDRFYPNDLWVVVFQ 233
Cdd:cd15214    87 MLTLGAIAIDRYYAVLYPM--VYPMKITGNRAVLalVYIWLHSLIGCLPPLFGWSSLEFDRfKWMCVAAWHKEAGYTAFW 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 fqhIMVGLILPGIVILSCYCIIISKlshSKGHQKrKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEfenTV 313
Cdd:cd15214   165 ---QVWCALLPFVVMLVCYGFIFRV---ARANQC-KAFITILVVLGAFVTTWGPYMVVISTEALWGKNSVSPQLE---TL 234
                         250       260
                  ....*....|....*....|....
gi 1127774881 314 HKWISITEALAffhcclNPILYAF 337
Cdd:cd15214   235 ATWLSFTSAVC------HPLIYGL 252
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
80-340 5.63e-12

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 65.98  E-value: 5.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF----VITLPFWAVDAVAnWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15198     9 VILVAGVAGNTTVLCWLCGGRRRKSRMNFLLLQLALADLLViggtALSQIIWELLGDR-WMAGDVACRLLKLLQASARGA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQ-RPRKLLAekvvyVGvWIPALLLTIP-------DFIFANVSEADDRYICDR-FYPND 226
Cdd:cd15198    88 SANLVVLLALDRHQAIRAPLGQPlRAWKLAA-----LG-WLLALLLALPqayvfrvDFPDDPASAWPGHTLCRGiFAPLP 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LW-VVVFQFQHIMVGLILPGIVILSCY----CIIISKLSHSKGHQ----------------------KRKALKTTVILIL 279
Cdd:cd15198   162 RWhLQVYATYEAVVGFVAPVVILGVCYgrllLKWWERANQAPGAKkpwkkpskshlratapsalpraKVKTLKMTLVIAL 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 280 AFFACWLPYYIgisidsfilLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGA 340
Cdd:cd15198   242 LFVGCSLPYFI---------AELAAAFGSGDWEPEKVAAALGVMAVANSATNPFVFLFFNA 293
7tmA_OT_R cd15387
oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
76-289 7.34e-12

oxytocin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Oxytocin is a peptide of nine amino acids synthesized in the hypothalamus and is released from the posterior pituitary gland. Oxytocin plays an important role in sexual reproduction of both sexes and is structurally very similar to vasopressin. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320509 [Multi-domain]  Cd Length: 297  Bit Score: 65.61  E-value: 7.34e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI--TLPFWAVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15387     5 TVLALILFLALTGNICVLLAIHTTRHKHSRMYFFMKHLSIADLVVAVfqVLPQLIWDITFRFYGPDFLCRLVKYLQVVGM 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKllaEKVVYVGVWIPALLLTIPD-FIFANVSEADDRYIC--DRFYPndlWVV 230
Cdd:cd15387    85 FASTYMLLLMSIDRCLAICQPLRSLHRRS---DRVYVLFSWLLSLVFSIPQvHIFSLREVGNGVYDCwaDFIQP---WGP 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFQHIMVGL-ILPGIVILSCYCIII--------------SKLSHSKGHQKRKAL-----------------KTTVILI 278
Cdd:cd15387   159 KAYITWITLSVyIIPVLILSVCYGLISfkiwqnvklktrreTKTPLSSAASGGAALarvssvkliskakirtvKMTFVIV 238
                         250
                  ....*....|.
gi 1127774881 279 LAFFACWLPYY 289
Cdd:cd15387   239 LAYIVCWTPFF 249
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
71-343 8.16e-12

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 64.82  E-value: 8.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  71 KIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVI 148
Cdd:cd15333     4 KISLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVsILVMPISIVYTVTGtWTLGQVVCDIWLSS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW 228
Cdd:cd15333    84 DITCCTASILHLCVIALDRYWAITDAVEYSKKRTPKRAAVMIALVWVISISISLPPFFWRQAKAEEEVSECVVNTDHILY 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQhimvGLILPGIVILSCYciiiSKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgISidsfILLEIIKQGCE 308
Cdd:cd15333   164 TVYSTVG----AFYIPTLLLIALY----GRIYVEARARERKATKTLGIILGAFIVCWLPFFI-IS----LVLPICKDACW 230
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1127774881 309 FENTVHKWISIteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15333   231 FHLAIFDFFTW---LGYLNSLINPIIYTMSNEDFK 262
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
80-345 8.86e-12

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 65.14  E-value: 8.86e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL-LFVITLPFWAV-DAVANWYFGNFLCKavhvIYTVNLY--- 154
Cdd:cd15073     9 VAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLgVSIIGYPFSAAsDLHGSWKFGYAGCQ----WYAFLNIffg 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 -SSVLILAFISLDRYLAIVhatnsqrpRKLLAEKVVY-------VGVWIPALLLTIPDFI-FANVSEADDRYICD-RFYP 224
Cdd:cd15073    85 mASIGLLTVVAVDRYLTIC--------RPDLGRKMTTntytvmiLLAWTNAFFWAAMPLVgWASYALDPTGATCTiNWRK 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLS-HSKG-----------HQkRKALKTTVILILAFFACWLPYYIGI 292
Cdd:cd15073   157 NDSSFVSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKkVLASdclesvnidwtDQ-NDVTKMSVIMIVMFLVAWSPYSIVC 235
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 293 SIDSFilleiikqgcEFENTVHKWISITEAL-AFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15073   236 LWASF----------GEPKKIPPWMAIIPPLfAKSSTFYNPCIYVIANKKFRRA 279
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
74-343 1.00e-11

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 64.93  E-value: 1.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTV 151
Cdd:cd15402     3 LACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHngWNLGYLHCQISGFLMGL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHatnSQRPRKLLAEK--VVYVG-VWIPALLLTIPDfIFANVSEADDRYICDRFYPN--- 225
Cdd:cd15402    83 SVIGSIFNITGIAINRYCYICH---SLKYDKLYSDKnsLCYVLlIWVLTVAAIVPN-LFVGSLQYDPRIYSCTFAQSvss 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 --DLWVVVFQFqhimvglILPGIVILSCYC---IIISKLSHSKGHQKRKALK--------TTVILILAFFACWLPYyigi 292
Cdd:cd15402   159 ayTIAVVFFHF-------ILPIIIVTFCYLriwILVIQVRRRVKPDNKPKLKphdfrnfvTMFVVFVLFAVCWAPL---- 227
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 293 sidSFILLEIIKQGCEFENTVHKWISITEA-LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15402   228 ---NFIGLAVAVDPETIVPRIPEWLFVASYyMAYFNSCLNAIIYGLLNQNFR 276
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
72-343 1.26e-11

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 65.20  E-value: 1.26e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVM-GYQKK---LRSMTDkYRLHLSVADLL-FVITLPFWAVDAVAN---WYFGNFLCK 143
Cdd:cd15135     1 ITLTLLYSLILVAGILGNSATIKVTqVLQKKgylQKSVTD-HMVSLACSDLLvLLLGMPVELYSAIWDpfaTPSGNIACK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 144 AVHVIYTVNLYSSVLILAFISLDRYLAIVH-----ATNSQRPRKLLAekvvyvGVWIPALLLTIPdFIFA----NVSEAD 214
Cdd:cd15135    80 IYNFLFEACSYATILNVATLSFERYIAICHpfkykALSGSRVRLLIC------FVWLTSALVALP-LLFAmgteDPLEAF 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 215 DRYICDRFYPND----LWV--------VVFQ---FQHIMVGLILPGIVILSCYCIIISKLSHSKG--------------- 264
Cdd:cd15135   153 PSYRGTRHHCQDqksnLTIctslsskwTVFQasiFSAFVLYLLVLASVAFMCRRMMRALMGSKKGavavkgpggsvqllr 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 265 ----HQKRKALKTTVI----LILAFFACWLPYYIgisidSFILLEIIKQGCEFENTVHKWIS---ITEALAFFHCCLNPI 333
Cdd:cd15135   233 khesAEGKTARKQTILflglIVGTLAVCWMPNQI-----RRIMAAAKPKDDWTRSYFRAYIIllpIADTFFYLSSVLNPL 307
                         330
                  ....*....|
gi 1127774881 334 LYAFLGAKFK 343
Cdd:cd15135   308 LYNLSSQQFR 317
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
76-343 1.63e-11

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 64.40  E-value: 1.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFWAVDAVANWYF--GNFLCKAVHVIYTVN 152
Cdd:cd15358     5 VTYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLvLLLGMPLELYEMWSNYPFllGAGGCYFKTLLFETV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSE--------ADDRYICDRFYP 224
Cdd:cd15358    85 CFASILNVTALSVERYIAVVHPLKAKYVVTRTHAKRVIGAVWVVSILCSIPNTSLHGIFQltvpcrgpVPDSATCMLVKP 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFQHIMVgLILPGIVILSCYCIIISKLSHSK---------------------GHQKRKALKTT---VILILA 280
Cdd:cd15358   165 RWMYNLIIQITTLLF-FFLPMGTISVLYLLIGLQLKREKmllvleakgskagdsyqhrriQQEKRRRRQVTkmlFVLVVV 243
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 281 FFACWLPYYIGISIDSFilleiIKQGCEFENTVHKWISITEALAFF-HCCLNPILYAFLGAKFK 343
Cdd:cd15358   244 FGICWAPFHTDRLMWSF-----ISQWTGELHLAFQYVHIISGVFFYlSSAANPVLYNLMSTRFR 302
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
80-343 1.75e-11

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 64.16  E-value: 1.75e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN--WYFGNFLCK---AVHVIYTVnl 153
Cdd:cd15305     9 IIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDyaWPLPRYLCPiwiSLDVLFST-- 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 ySSVLILAFISLDRYLA----IVHATNSQRPRKLLAEKVVY-----VGVWIPALLLTIPDFIFANVSEADDryicdrfyp 224
Cdd:cd15305    87 -ASIMHLCAISLDRYVAirnpIEHSRFNSRTKAMMKIAAVWtisigISMPIPVIGLQDDEKVFVNGTCVLN--------- 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQFqhimVGLILPGIVILSCYCIIISKLSHSKG-HQKRKALKTTVILILAFFACWLPYYIgisidSFILLEII 303
Cdd:cd15305   157 DENFVLIGSF----VAFFIPLIIMVITYCLTIQVLQRQQAiNNERRASKVLGIVFFLFLIMWCPFFI-----TNILSVLC 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEfENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15305   228 KEACD-QKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYR 266
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
77-343 2.27e-11

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 64.10  E-value: 2.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15976     6 VSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAeDWPFGVEMCKLVPFIQKASVG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIV---HATNSQRPRKLLAEKVVyvgVWIPALLLTIPDFIFANVSEADDR----YIC-------- 219
Cdd:cd15976    86 ITVLSLCALSIDRYRAVAswsRIKGIGVPKWTAVEIVL---IWVVSIILAVPEAIGFDMITMDYKgellRICllhpiqkt 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 --DRFYP--NDLWVVVFQFqhiMVGLILPGIVILSCYCIIISKLS--------HSKghQKRKALKTTVILILAFFACWLP 287
Cdd:cd15976   163 afMQFYKtaKDWWLFSFYF---CLPLACTAVFYTLMTCEMLRKKNgmqialndHLK--QRREVAKTVFCLVLVFALCWLP 237
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 288 YYIGISIDSFILLEIIKQGCEFEN--TVHKWISITeaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15976   238 LHLSRILKLTIYDEKDPNRCELLSffLVLDYIGIN--MASLNSCINPIALYLVSKRFK 293
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
74-345 2.53e-11

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 63.42  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPF-WAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15322     3 LIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFsLANEVMGYWYFGKVWCEIYLALDVL 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRY-ICDrfYPNDLWVV 230
Cdd:cd15322    83 FCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKCIIFIVWVISAVISFPPLITIEKKSGQPEGpICK--INDEKWYI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQfqhIMVGLILPGIVILSCYCIIISKlshSKGHQKRKALKTTVIlILAFFACWLPYYIGISIDSFIlleiikqGCEFE 310
Cdd:cd15322   161 ISS---CIGSFFAPCLIMVLVYIRIYQI---AKNREKRFTFVLAVV-IGVFVICWFPFFFTYTLTAVC-------DCSVP 226
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 311 NTVHKWIsiteaLAFFHC--CLNPILYAFLGAKFKTS 345
Cdd:cd15322   227 ETLFKFF-----FWFGYCnsSLNPVIYTIFNHDFRRA 258
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
75-292 3.03e-11

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 63.42  E-value: 3.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRL--HLSVADLL-FVITLPFwAVDAVAN---WYFGNFLCKAVHVI 148
Cdd:cd14981     4 PAPPALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLgILLTSPV-VLAVYASnfeWDGGQPLCDYFGFM 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTI-PdfiFANVSEADDRYICD----RFY 223
Cdd:cd14981    83 MSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASlP---LLGLGSYVLQYPGTwcflDFY 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 224 PNDLWVVVFQFQHIMVGLILPgIVILSCYCIIISKLSH----------SKGHQKRKALKTT--VILILA----FFACWLP 287
Cdd:cd14981   160 SKNTGDAAYAYLYSILGLLIL-LVTLLCNLLVIITLLRmrrrkkrhrrSRRSARRQKRNEIqmVVLLLAitvvFSVCWLP 238

                  ....*
gi 1127774881 288 YYIGI 292
Cdd:cd14981   239 LMIRV 243
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
77-290 3.21e-11

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 63.31  E-value: 3.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15008     5 VFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLsVASAPFVLLQFTSgRWTLGSAMCKLVRYFQYLTPG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHATNSQRPRKllAEKVVYVGVWIPALLLTIPDFIFANVSEADdryiCDRFYPNDLWV-VVFQ 233
Cdd:cd15008    85 VQIYVLLSICVDRFYTIVYPLSFKVSRE--KAKKMIAASWLFDAAFVSPALFFYGSNWGP----HCNFFLPDSWDgAAYA 158
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILSCYCIIIS-------------KLSHSKGHQKRKALKTTVILILAFFACWLPYYI 290
Cdd:cd15008   159 IIHLLVGFLVPSILIILFYQKVIKyiwrigtdgrtvrRTMNIVPRTKVKTIKMFLMLNSMFLLSWLPFYV 228
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
72-345 3.34e-11

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 63.11  E-value: 3.34e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15298     1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIgAFSMNLYTVYIIKGyWPLGAVVCDLWLALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWV 229
Cdd:cd15298    81 YVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSN 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPgIVILSCYCIIISKLShskgHQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikQGCEF 309
Cdd:cd15298   161 PAVTFGTAIAAFYLP-VVIMTVLYIHISLAS----ARERKVTRTIFAILLAFILTWTPYNVMVLVNTFC------QSCIP 229
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1127774881 310 ENTvhkWiSITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15298   230 DTV---W-SIGYWLCYVNSTINPACYALCNATFKKT 261
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
72-337 4.68e-11

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 62.95  E-value: 4.68e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCKAVHVIY 149
Cdd:cd15316     1 VILYIVLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTvMPFSTVRSVEScWYFGESFCTFHTCCD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFiFANVSEADDRYICD--------R 221
Cdd:cd15316    81 VSFCYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVF-YTGVNDDGLEELVNalncvggcQ 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVV-----FQFQHIMVGLILPGIVILSCYCIIISKLSHSK-----------GHQKRKALKTTVILILAFFACW 285
Cdd:cd15316   160 IILNQNWVLVdfllfFIPTFAMIILYGKIFLVAKQQARKIEMTSSKAesssesykdrvARRERKAAKTLGITVIAFLVSW 239
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 286 LPYYIGISIDSFilLEIIKQGCEFEntvhkwisITEALAFFHCCLNPILYAF 337
Cdd:cd15316   240 LPYLIDVLIDAF--MNFITPPYIYE--------ICCWCAYYNSAMNPLIYAL 281
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
72-345 5.27e-11

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 62.68  E-value: 5.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIY 149
Cdd:cd17790     1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTVNNYFLLSLACADLIIgAFSMNLYTTYILmGHWALGTVACDLWLALD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYSSVLILAFISLDRYLAIVHATnSQRPRKLLAEKVVYVGV-WIPALLLTIPDFIFANVSEADDRYICDRFYPNDLW 228
Cdd:cd17790    81 YVASNASVMNLLIISFDRYFSITRPL-TYRAKRTPRRAAIMIGLaWLISFVLWAPAILFWQYLVGERTVLAGQCYIQFLS 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 229 VVVFQFQHIMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFIlleiikQGCE 308
Cdd:cd17790   160 QPIITFGTAIAAFYLPVTIMIILYWRI-----YRETIKEKKAARTLSAILLAFILTWTPYNIMVLVSTFC------KDCV 228
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 309 FENTvhkWiSITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd17790   229 PKTL---W-ELGYWLCYVNSTVNPMCYALCNKSFRDT 261
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
80-345 7.62e-11

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 62.28  E-value: 7.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVanwyFGNFLCKAVHVIYTVNL----- 153
Cdd:cd15307    10 LVLGT-AAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVaVLVMPLGILTLV----KGHFPLSSEHCLTWICLdvlfc 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQR--PRKLLAEKVVYvgVWIPALLLTIPdfifANVSEADDRYICDRFYPNDLWVVV 231
Cdd:cd15307    85 TASIMHLCTISVDRYLSLRYPMRFGRnkTRRRVTLKIVF--VWLLSIAMSLP----LSLMYSKDHASVLVNGTCQIPDPV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKR------KALKTTVILILAFFACWLPYyigisidsFILLEIIKQ 305
Cdd:cd15307   159 YKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRSRHGRiirleqKATKVLGVVFFTFVILWSPF--------FVLNLLPTV 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 306 GCEFENTVHKW-ISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15307   231 CAECEERISHWvFDVVTWLGYASSMVNPIFYTIFNKVFRQA 271
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
86-337 2.14e-10

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 60.77  E-value: 2.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  86 IVGNGLVILVMGYQKKLRsmTDKYRL--HLSVADLL--------FVITLPFWAVDAVANWYFgnflckaVHVIYTVNLYS 155
Cdd:cd14972    13 VVENSLVLAAIIKNRRLH--KPMYILiaNLAAADLLagiafvftFLSVLLVSLTPSPATWLL-------RKGSLVLSLLA 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLL-TIPDFIFaNVSEADDRYICDRFYPNDLWVVVFqf 234
Cdd:cd14972    84 SAYSLLAIAVDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVLLaLLPVLGW-NCVLCDQESCSPLGPGLPKSYLVL-- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 235 qhIMVGLILPGIVILSCYCII----------ISKLSHSK-GHQK---RKALKTTVILILAFFACWLPYYIGISIDSFill 300
Cdd:cd14972   161 --ILVFFFIALVIIVFLYVRIfwclwrhanaIAARQEAAvPAQPstsRKLAKTVVIVLGVFLVCWLPLLILLVLDVL--- 235
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 301 eiikqgCEFENTVHKWISITEALAFFHCCLNPILYAF 337
Cdd:cd14972   236 ------CPSVCDIQAVFYYFLVLALLNSAINPIIYAF 266
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
76-343 4.52e-10

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 60.06  E-value: 4.52e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFwavdAVAN-----WYFGNFLCKaVHVIY 149
Cdd:cd15065     4 IFLSLIIVLAIFGNVLVCLAIFTDRRLRKKSNLFIVSLAVADLLVaLLVMTF----AVVNdllgyWLFGETFCN-IWISF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNL-YSSVLILAFISLDRYLAIVHATNSQR---PRKLLaekVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPN 225
Cdd:cd15065    79 DVMCsTASILNLCAISLDRYIHIKKPLKYERwmtTRRAL---VVIASVWILSALISFLPIHLGWHRLSQDEIKGLNHASN 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQ------HIMVGLILPGIVILSCYCIII----------------------------SKLSHSKGHQKRKAL 271
Cdd:cd15065   156 PKPSCALDLNptyavvSSLISFYIPCLVMLLIYSRLYlyarkhvvniksqklpsesgskfqvpslSSKHNNQGVSDHKAA 235
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 272 KTTVILILAFFACWLPyyigisidsFILLEIIKQGCEfENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15065   236 VTLGIIMGVFLICWLP---------FFIINIIAAFCK-TCIPPKCFKILTWLGYFNSCLNPIIYSIFNSEFR 297
7tmA_Beta1_AR cd15958
beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...
79-335 7.34e-10

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320624 [Multi-domain]  Cd Length: 298  Bit Score: 59.53  E-value: 7.34e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAV-ANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15958     8 ALIVLLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMgLLVVPFGATLVVrGRWLYGSFFCELWTSVDVLCVTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIvhaTNSQRPRKLLAE---KVVYVGVW-IPALLLTIPDFIFANVSEAD-------DRYICDrFYPN 225
Cdd:cd15958    88 IETLCVIAIDRYLAI---TSPFRYQSLLTRaraKGIVCTVWaISALVSFLPIMMHWWRDEDDqalkcyeDPGCCD-FVTN 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQFQHIMVGLILPGIVILSCYCII---ISKLSHSKGH----------------------QKRKALKTTVILILA 280
Cdd:cd15958   164 RAYAIASSIISFYIPLLIMIFVYLRVYREAkkqIKKIDKCEGRfhntltglgrkckrrpsrilalREQKALKTLGIIMGV 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 281 FFACWLPYYIGISIDSFilleiikqgceFENTVHKWISIT-EALAFFHCCLNPILY 335
Cdd:cd15958   244 FTLCWLPFFLVNVVNVF-----------NRELVPDWLFVFfNWLGYANSAFNPIIY 288
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
72-345 1.16e-09

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 58.50  E-value: 1.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL---FVITLpFWAVDAVANWYFGNFLCKAVHVI 148
Cdd:cd15300     1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIigiFSMNL-YTSYILMGYWALGSLACDLWLAL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVseaddrYICDRFYPND-- 226
Cdd:cd15300    80 DYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILCWQY------FVGKRTVPERec 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 ----LWVVVFQFQHIMVGLILPGIVILSCYCIIisklsHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFillei 302
Cdd:cd15300   154 qiqfLSEPTITFGTAIAAFYIPVSVMTILYCRI-----YKETIKERKAAQTLSAILLAFIITWTPYNIMVLVSTF----- 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1127774881 303 ikqgCEFENTVHKWiSITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15300   224 ----CSDCIPLTLW-HLGYWLCYVNSTVNPMCYALCNKTFRKT 261
7tmA_5-HT6 cd15054
serotonin receptor subtype 6, member of the class A family of seven-transmembrane G ...
80-343 1.38e-09

serotonin receptor subtype 6, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT6 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT6 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. The 5-HT6 receptors mediates excitatory neurotransmission and are involved in learning and memory; thus they are promising targets for the treatment of cognitive impairment. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320182 [Multi-domain]  Cd Length: 267  Bit Score: 58.28  E-value: 1.38e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTgIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL--FVITLPFWAVDAVANWYFGNFLCkAVHVIYTVNLYS-S 156
Cdd:cd15054    10 IILLT-VAGNSLLILLIFTQRSLRNTSNYFLVSLFMSDLMvgLVVMPPAMLNALYGRWVLARDFC-PIWYAFDVMCCSaS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIV----HATNSQRPRKLlaekVVYVGVWIPALLLTIPDFIFA-----------NVSEADDRYICdR 221
Cdd:cd15054    88 ILNLCVISLDRYLLIIsplrYKLRMTPPRAL----ALILAAWTLAALASFLPIELGwhelghertlpNLTSGTVEGQC-R 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFQfqhiMVGLILPGIVILSCYCIIIsklshskgHQKRKALK---TTVILILAFFACWLPYYIGISIDSFI 298
Cdd:cd15054   163 LLVSLPYALVAS----CLTFFLPSGAICFTYCRIL--------LAARKALKaslTLGILLGMFFVTWLPFFVANVVQAVC 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 299 llEIIKQGCeFEntVHKWisiteaLAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15054   231 --DCVSPGL-FD--VLTW------LGYCNSTMNPIIYPLFMRDFK 264
7tmA_GPR139 cd15919
G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G ...
73-346 2.68e-09

G-protein-coupled receptor GPR139, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR139, a vertebrate orphan receptor, is very closely related to GPR142, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320585 [Multi-domain]  Cd Length: 270  Bit Score: 57.60  E-value: 2.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIY-SIIFLTGIVGNGLVILVMGYQKKLRSMTD-KYRLHLSVAD---LLFVITLPFWAVDAVANWYFGNFLCKAVHV 147
Cdd:cd15919     1 FVPVIYySLLLCLGLPANILTVIILSQLVARRQKSSyNYLLALAAADilvLFFIVFVDFLLEDFILNKQMPQVLDKIIEV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADdrYICDRFYPNDL 227
Cdd:cd15919    81 LEFSSIHTSIWITVPLTIDRYIAVCHPLKYHTVSYPARTRKVIVSVYITCFLTSIPYYWWPNIWIED--YTSTSMHHVLI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVvvfqfqHIMVGLILPGIVILSCYCIIISKLSHSKGHQKR--KALKTTVIL--ILAFFAC-WLPYYIgisidsFILLEI 302
Cdd:cd15919   159 WI------HCFTVYLVPCSIFFVLNSIIVYKLRRKSNFRLRgySTGKTTAILftITSIFAIlWAPRII------MILYHL 226
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 303 IKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15919   227 YVSPINNSWLVHIVSDIANMLALLNTAINFFLYCFISKRFRTMA 270
7tmA_GPR61_GPR62-like cd15220
G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G ...
83-290 3.51e-09

G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the orphan receptors GPR61 and GPR62, which are both constitutively active and predominantly expressed in the brain. While GPR61 couples to G(s) subtype of G proteins, the signaling pathway and function of GPR 62 are unknown. GPR61-deficient mice displayed significant hyperphagia and heavier body weight compared to wild-type mice, suggesting that GPR61 is involved in the regulation of food intake and body weight. GPR61 transcript expression was found in the caudate, putamen, and thalamus of human brain, whereas GPR62 transcript expression was found in the basal forebrain, frontal cortex, caudate, putamen, thalamus, and hippocampus. Both receptors share the highest sequence homology with each other and comprise a conserved subgroup within the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. Members of this subgroup contain [A/E]RY motif, a variant of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the class A GPCRs and important for efficient G protein-coupled signal transduction.


Pssm-ID: 410633 [Multi-domain]  Cd Length: 264  Bit Score: 57.08  E-value: 3.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  83 LTGIVGNGLVILVMGYQKKLRSMTdkYRLHLSVADLLFVITL-PFWAVDAVA---NWYFGNFLCKAVHVIYTVNLYSSVL 158
Cdd:cd15220    11 LTALVGNTAVMVVIAKTPHLRKFA--FVCHLCVVDLLAALLLmPLGILSSSPfflGVVFGEAECRVYIFLSVCLVSASIL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFI---FANVSEADDRYICDRFYPNDLWVVVFQFQ 235
Cdd:cd15220    89 TISAISVERYYYIVHPMRYEVKMTIGLVAAVLVGVWVKALLLGLLPVLgwpSYGGPAPIAARHCSLHWSHSGHRGVFVVL 168
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 236 HIMVGLILPGIVILSCYCIIISKLSHSKghqkrkALKTTVILILAFFACWLPYYI 290
Cdd:cd15220   169 FALVCFLLPLLLILVVYCGVFKVFGGGK------AALTLAAIVGQFLCCWLPYFA 217
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
74-288 3.58e-09

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 57.11  E-value: 3.58e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIVGNGLVILVMgYQKKLRSMTDKYRLHLSVADLLFVITLPF-WAVDAVANWYFGNFLCKAVHVIYTVN 152
Cdd:cd14994     4 LIFLYSVVLIGGVIGVILMSFLL-VKMNTRSVTTTAVINLIVVHSLFLLTVPFrIYYYASKTWKFGMPLCKMVSAMIHIH 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFA-NVSEADDRYICDRFYPNDLWVVV 231
Cdd:cd14994    83 MHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVPVFVKEyGSSSSYNSDQCFKFHKELEVHYV 162
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 232 FQFQHIMVGLILPGIVILSCYCIII-----SKLSHSK-GHQKRKALKTTVILILAFFACWLPY 288
Cdd:cd14994   163 KVLNYIIICIVLIVTLALLGFQVFIlghvyRKLRASLlSHQEFWAQMKSLFFIVVIIVCFVPY 225
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
72-288 4.17e-09

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 56.77  E-value: 4.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNgLVILVMGYQKK-LRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVI 148
Cdd:cd15404     1 VILSAVMIFILLVSFLGN-FVVCLMVYQKAaMRSAINILLASLAFADMMLaVLNMPFALVTIITTrWIFGDAFCRVSAMF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKllaEKVVYVGVWIPALLLTIPDFI-FANVSEADDRYICDRFYPNDL 227
Cdd:cd15404    80 FWLFVMEGVAILLIISIDRFLIIVQKQDKLNPYR---AKVLIAVSWAVSFCVAFPLAVgSPDLQIPSRAPQCVFGYTTNP 156
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSkghqKRKALKTTVILILAFFACWLPY 288
Cdd:cd15404   157 GYQAYVILIMLIFFFIPFMVMLYSFMGILNTVRSF----KTRAFTTILILFIVFTVCWAPF 213
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
73-345 4.82e-09

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 56.58  E-value: 4.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAV--DAVANWYFGNFLCKAVHVIYT 150
Cdd:cd15309     2 YYAMLLTLLIFVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVylEVVGEWRFSRIHCDIFVTLDV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAI----VHATNSQRPRKLlaeKVVYVGVWIPALLLTIPDFIFANVSeadDRYICdrFYPND 226
Cdd:cd15309    82 MMCTASILNLCAISIDRYTAVampmLYNTRYSSKRRV---TVMISVVWVLSFAISCPLLFGLNNT---DQNEC--IIANP 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFQHIMVGLILPGIVILSCYCIIisklshskgHQKRKALKTTVILILAFFACWLPYYIgisidsfilLEIIKQG 306
Cdd:cd15309   154 AFVVYSSIVSFYVPFIVTLLVYVQIYIVL---------QKEKKATQMLAIVLGVFIICWLPFFI---------THILNMH 215
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1127774881 307 CEFeNTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15309   216 CDC-NIPPALYSAFTWLGYVNSAVNPIIYTTFNIEFRKA 253
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
80-343 5.03e-09

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 56.82  E-value: 5.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVI---LVMGYQKKLRSMtdkYRLHLSVADLLFVITLPFWA-VDA----VANWYFGNF----LCKAVHV 147
Cdd:cd15137     9 VVGIIALLGNLFVLiwrLKYKEENKVHSF---LIKNLAIADFLMGVYLLIIAsVDLyyrgVYIKHDEEWrsswLCTFAGF 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVyVGVWIPALLLTIPDFIfaNVSEADDRY----IC---- 219
Cdd:cd15137    86 LATLSSEVSVLILTLITLDRFICIVFPFSGRRLGLRRAIIVL-ACIWLIGLLLAVLPLL--PWDYFGNFYgrsgVClplh 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 -DRFYPnDLW---VVVFqfqhIMVGLILpGIVILSCYCIIISKLSHS-KGHQKRKALKTTVI------LILAFFACWLPY 288
Cdd:cd15137   163 iTDERP-AGWeysVFVF----LGLNFLA-FVFILLSYIAMFISIRRTrKAAASRKSKRDMAVakrfflIVLTDFLCWIPI 236
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 289 YIgISIDSFIlleiikqGCEFENTVHKWISItealaFF---HCCLNPILYAFLGAKFK 343
Cdd:cd15137   237 IV-IGILALS-------GVPIPGEVYAWVAV-----FVlpiNSALNPILYTLSTPKFR 281
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
77-290 7.88e-09

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 56.41  E-value: 7.88e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLY 154
Cdd:cd15957     6 VMSLIVLAIVFGNVLVITAIAKFERLQTVTNYFITSLACADLVMgLAVVPFGAAHILLKtWTFGNFWCEFWTSIDVLCVT 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIvhaTNSQRPRKLLAE---KVVYVGVWIPALLLT-IP---DFIFANVSEADDRY---ICDRFYP 224
Cdd:cd15957    86 ASIETLCVIAVDRYFAI---TSPFKYQSLLTKnkaRVIILMVWIVSGLTSfLPiqmHWYRATHQEAINCYaeeTCCDFFT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDLWVVVFQfqhiMVGLILPGIVILSCYCII-------ISKLSHSKGH-------------------------QKRKALK 272
Cdd:cd15957   163 NQAYAIASS----IVSFYVPLVIMVFVYSRVfqeakrqLQKIDKSEGRfhnqnidqngsgggggnrrrskfclKEHKALK 238
                         250
                  ....*....|....*...
gi 1127774881 273 TTVILILAFFACWLPYYI 290
Cdd:cd15957   239 TLGIIMGTFTLCWLPFFI 256
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
83-355 9.89e-09

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 55.92  E-value: 9.89e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  83 LTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVI----TLPFWAVDAVANWYFGNFLCKAV-HVIYTVNLYssv 157
Cdd:cd15108    12 VCGMAGNGLVVWLLSCRGR-RTPFCVYVLHLAVADLLFLLcmasTLSLETSPLVITHDLAYEVVRRVkYFAYTASLS--- 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 lILAFISLDRYLAIVHAT--NSQRPRKLLAekVVYVGVWIPALLLTIPDFIFanvseaddryiCDRFYPNDLW--VVVFQ 233
Cdd:cd15108    88 -LLTAISTQRCLSVLFPIwyKCHQPRHLSA--VVCALLWALSLLMNVLASFF-----------CSEFWHPDEWqcFKVDM 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 234 FQHIMVGLILPGIVILS--CYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPyyigISIDSFILLeiikqgcefen 311
Cdd:cd15108   154 VFSFLIMGIFTPVMALSslILFVRVRRSSRQWRRRPTRLYVVVLASVLVFLACALP----LGIYWFLLY----------- 218
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 312 tvhkWISITEALAFFHCCL-----------NPILYAFLGAKFKTSAQHALTSVSR 355
Cdd:cd15108   219 ----WLDLPQEVKTLFSCLsrlsssvsssaNPVIYFLVGSRGSRRLREPLGAVLQ 269
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
67-343 1.50e-08

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 55.57  E-value: 1.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  67 ANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT--LPFWAVDAVANWYFGNFLCK- 143
Cdd:cd15082     9 APWNFTVLAALMFVVTSLSLAENFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTggTISFLTNARGYFFLGVWACVl 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 144 ---AVHVIYTVNLYSsvliLAFISLDRYLAIVHATNSQRPR-KLLAEKVVYVgvWIPALLLTIPDFI-FANVSEADDRYI 218
Cdd:cd15082    89 egfAVTFFGIVALWS----LAVLAFERFFVICRPLGNIRLQgKHAALGLLFV--WTFSFIWTIPPVLgWSSYTVSKIGTT 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 219 CD-RFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---SHSKGH------QKRKALKTTVILILAFFACWLPY 288
Cdd:cd15082   163 CEpNWYSGNMHDHTYIITFFTTCFILPLGVIFVSYGKLLQKLrkvSNTQGRlgnarkPERQVTRMVVVMIVAFMVCWTPY 242
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 289 YIgisidsfilLEIIKQGCEfenTVHKWISITEALAFFH---CCLNPILYAFLGAKFK 343
Cdd:cd15082   243 AA---------FSILVTAHP---TIHLDPRLAAIPAFFSktaAVYNPIIYVFMNKQFR 288
7tmA_ACKR1_DARC cd15010
Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G ...
113-339 1.55e-08

Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors; Atypical chemokine receptor 1 (ACKR1), also known as DARC (Duffy antigen receptor for chemokines) or Fy glycoprotein (GpFy), was originally identified on erythrocytes. ACKR1 is also ubiquitously expressed by endothelial cells of venules and is highly promiscuous among all chemokine receptor. It binds many proinflammatory chemokines from both the CC and CXC subfamilies, including CCL2, CCL5, CCL7, CCL11, CXCL1, CXCL2, CXCL3, and CXCL5. Erythrocyte ACKR1 is thought to act as a chemokine sink, limiting the levels of circulating chemokines, thereby controlling leukocyte activation. ACKR1-deficient erythrocytes are shown to confer resistance to the malarial parasite, Plasmodium vivax. On the other hand, ACKR1-expressing endothelial cells can internalize chemokines. ACKR1-internalized chemokines can be moved intact across the endothelium and promotes neutrophil transmigration. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 410631  Cd Length: 257  Bit Score: 55.18  E-value: 1.55e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 113 LSVADLLFVITLPFWAVDAVANWyfGNFLCKAVHVIYTVNLYS-SVLILAFISLDRYLAIVhatnsQRPRKLLAekvVYV 191
Cdd:cd15010    43 LAVGSALFSIVVPILAPGLSQGW--GTGLCKLAYLVWYGSAFAqALLVGCHACLGPWLGWG-----QVPGLTLG---LAV 112
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 192 GVWIPALLLTIPDFIFANVSEAddryICDRFYPNDLwvVVFQFQHIMvglilpgivilSCYCIII---SKLSHSKG--HQ 266
Cdd:cd15010   113 GLWGAAALLALPVALASGTSGG----PCTLRSSRDL--EALYLTHLA-----------ACLAIFVllpLGLLGAKGlkTA 175
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 267 KRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIK-QGCEFENTVHKWISITEALAFFHCCLNPILYAFLG 339
Cdd:cd15010   176 LRVGPGPWVGVLWLWFIFWWPYGVVLGLDFLVRSKLLLlSTCGAQEALDYMLGLSEALGILHCVATPLLLALVC 249
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
80-353 1.56e-08

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 55.10  E-value: 1.56e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTdKYRLHLSVADLLFVITLPFWAVDAVANWYFgnflCKAVHVIYTVNL------ 153
Cdd:cd15110     9 IICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCIFILSIMYIGPFNF----SHSRDYVAMLIFiilflf 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 -YSSVLILAF-ISLDRYLAIVHAT--NSQRPRKLLAekVVYVGVWIPALLLTIPDFIFANVSEADDRYICdrfypndlwV 229
Cdd:cd15110    84 gYNTGLYLLTaISVERCLSVLYPIwyRCHRPKHQSA--IVCGLLWALSVLMTSLEYLMCIDEGFHVRNEC---------R 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 230 VVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRK---ALKTTVILILAF-FACWLPYYIGISIDSFILLEiikq 305
Cdd:cd15110   153 AVLIFIGILTFLVFTPLMLISSLILFIKVRCNSQRRHPGKlyiIIMLTVIFFLIFaMPMRVLLLLNYLHHSSFLFS---- 228
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 306 gcefentvhkwISITEALAFFHCCLNPILYAFLGA----KFKTSAQHALTSV 353
Cdd:cd15110   229 -----------NPVPFLLSTVNSSINPIVYFLVGSlrrkRIKKSLKVALQRV 269
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
76-288 1.72e-08

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 55.11  E-value: 1.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAV-ANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15336     5 SVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSLhKRWIFGEKGCELYAFCGALFG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFI--FANVSEAdDRYIC----------DR 221
Cdd:cd15336    85 ITSMITLLAISLDRYLVITKPLASIRWVSKKRAMIIILLVWLYSLAWSLPPLFgwSAYVPEG-LLTSCtwdymtftpsVR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 222 FYPNDLWVVVFqfqhimvglILPGIVILSCYCII----------ISKL------SHSKGHQKR----KALKTTVILILAF 281
Cdd:cd15336   164 AYTMLLFCFVF---------FIPLGIIIYCYLFIflairstgreVQKLgsqdrkEKAKQYQRMknewKMAKIAFVVILLF 234

                  ....*..
gi 1127774881 282 FACWLPY 288
Cdd:cd15336   235 VLSWSPY 241
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
80-343 1.84e-08

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 55.24  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLT--GIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLlfVITLPFWAVDAVA----NWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15400     7 LIFTTvvDILGNLLVIISVFRNRKLRNSGNVFVVSLALADL--VVALYPYPLVLVAifhnGWALGEMHCKVSGFVMGLSV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYIC------DRFYpnDL 227
Cdd:cd15400    85 IGSIFNITGIAINRYCYICHSFAYDKLYSRWNTLLYVCLIWALTVVAIVPNFFVGSLEYDPRIYSCtfvqtaSSSY--TI 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFqhimvglILPGIVILSCYC---IIISKLSHSKGHQKRKALK--------TTVILILAFFACWLPYyigisidS 296
Cdd:cd15400   163 AVVVIHF-------IVPITVVSFCYLriwVLVIQVRRKVKSESKPRLKpsdfrnflTMFVVFVIFAICWAPL-------N 228
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 297 FILLEIIKQGCEFENTVHKWISITEA-LAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15400   229 LIGLAVAINPQEMAPKVPEWLFVVSYfMAYFNSCLNAIIYGLLNQNFR 276
7tmA_D1A_dopamine_R cd15320
D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
79-337 3.21e-08

D1A (or D1) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320443 [Multi-domain]  Cd Length: 319  Bit Score: 54.62  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRS-MTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFlCKAVHVIYTVNLYS 155
Cdd:cd15320     9 SVLILSTLLGNTLVCAAVIRFRHLRSkVTNFFVISLAVSDLLVaVLVMPWKAVAEIAGfWPFGSF-CNIWVAFDIMCSTA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLT-IP-----------DFIFANVSEADDRYI-CDRF 222
Cdd:cd15320    88 SILNLCVISVDRYWAISSPFRYERKMTPKVAFIMISVAWTLSVLISfIPvqlnwhkakptSFLDLNASLRDLTMDnCDSS 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNdlwvvVFQFQHIMVGLILPGIVILSCYCII----------ISKLSHSKGHQKR------------------------ 268
Cdd:cd15320   168 LNR-----TYAISSSLISFYIPVAIMIVTYTRIyriaqkqirrISALERAAVHAKNcqnstgnrgsgdcqqpessfkmsf 242
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 269 ----KALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENT--VHKWisiteaLAFFHCCLNPILYAF 337
Cdd:cd15320   243 kretKVLKTLSVIMGVFVCCWLPFFILNCMVPFCKPTSTEPFCISSTTfdVFVW------FGWANSSLNPIIYAF 311
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
81-343 3.74e-08

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 54.56  E-value: 3.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  81 IFLTGIVGNGLVI---LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:PHA03234   41 IMLTLIIPMIIIVictLIIYHKVAKHNATSFYLITLFASDFLHMLCVFFLTLNREALFNFNQAFCQCVLFIYHASCSYSI 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIvhatnsQRpRKLLAEKVVYVGVWIPALLLT-----IPDFIFANVSEADDRY-ICDRFYPN----DL 227
Cdd:PHA03234  121 CMLAIIATIRYKTL------HR-RKKNDKKNNHIGRNIGILFLAsamcaIPAALFVKTEGKKGNYgKCNIHISSkkayDL 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WV---VVFQFqhimVGLILPgIVILSCYCIIISKLSHSKGHQK-RKALKTTVILILAFFACWLPYYIGISIDSFILLeII 303
Cdd:PHA03234  194 FIaikIVFCF----IWGIFP-TMIFSFFYVIFCKALHALTEKKhKKTLFFIRILILSFLCIQIPNIAILICEIAFLY-IA 267
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1127774881 304 KQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:PHA03234  268 NNSCFGLAQREILQIIIRLMPEIHCFSNPLVYAFTGGDFR 307
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
77-344 6.64e-08

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 53.37  E-value: 6.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWY--FGNFLCKAVHVIYTVNLY 154
Cdd:cd15109     6 IFLLLCLCGLVGNGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLgtFADYIRSVSRILGLCTFL 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 155 SSVLILAFISLDRYLAIVHAT--NSQRPRKLLAekVVYVGVWIPALLLT-IPDFIFANVSEADDRYICDRFypnDLwvvv 231
Cdd:cd15109    85 TGVSLLPAISIERCVSVIFPTwyWRRRPKRLSA--VVCALLWMLSLLVTcIHNYFCVFLGREAPGAACRHM---DI---- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 fqFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACwLPYYIGISIDSFILLEIIKQGCEFen 311
Cdd:cd15109   156 --FLGILLFLLFCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLV-SSIYLGIDWFLFWVFQIPAPFPEY-- 230
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 312 tvhkwisITEALAFFHCCLNPILYaFLGAKFKT 344
Cdd:cd15109   231 -------VTDLCICINSSAKPIVY-FLAGRDKS 255
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
79-335 1.64e-07

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 52.22  E-value: 1.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVA-NWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15959     8 SLAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMgLLVVPPGATILLTgHWPLGTTVCELWTSVDVLCVTAS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIvhaTNSQRPRKLLAE---KVVYVGVW-IPALLLTIP-------DFIFANVSEADDRYICDRFYPN 225
Cdd:cd15959    88 IETLCAIAVDRYLAI---TNPLRYEALVTKrraRTAVCLVWaISAAISFLPimnqwwrDGADEEAQRCYDNPRCCDFVTN 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFQfqhiMVGLILPGIVILSCYCIII---------------------SKLSHSKGHQKR-----------KALKT 273
Cdd:cd15959   165 MPYAIVSS----TVSFYVPLLVMIFVYVRVFvvatrqvrlirkdkvrfppeeSPPAESRPACGRrpsrllaikehKALKT 240
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1127774881 274 TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENtvhkWisiteaLAFFHCCLNPILY 335
Cdd:cd15959   241 LGIIMGTFTLCWLPFFVANIIKVFCRSLVPDPAFLFLN----W------LGYANSAFNPIIY 292
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
80-343 2.04e-07

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 51.76  E-value: 2.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL---FVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15306     9 MVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLvglFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFSTAS 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFI--FANVSEADDRYIC----DRFYPndlwvv 230
Cdd:cd15306    89 IMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVPIkgIETDVDNPNNITCvltkERFGD------ 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 vFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIgISIDSfilleIIKQGCEfE 310
Cdd:cd15306   163 -FILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFFI-TNITS-----VLCDSCN-Q 234
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1127774881 311 NTVHKWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15306   235 TTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFR 267
7tmA_Retinal_GPR cd15072
retinal G protein coupled receptor, member of the class A family of seven-transmembrane G ...
73-343 3.19e-07

retinal G protein coupled receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the retinal G-protein coupled receptor (RGR) found exclusively in retinal pigment epithelium (RPE) and Muller cells. RGR is a member of the class A rhodopsin-like receptor family. As with other opsins, RGR binds all-trans retinal and contains a conserved lysine reside on the seventh helix. RGR functions as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. Two mutations in RGR gene are found in patients with retinitis pigmentosa, indicating that RGR is essential to the visual process.


Pssm-ID: 320200 [Multi-domain]  Cd Length: 260  Bit Score: 51.21  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDA-VANWYFGNFLCKAVHVIYTV 151
Cdd:cd15072     2 AVGSILLVEALVGFSLNGLTILSFCKTRELRTPSNLLVLSLAVADMGISLNALVAASSSlLRRWPYGSEGCQAHGFQGFF 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHatnsqrPRKLLAEKVVY--VGVWI-PALLLTIPDFIFANVSEADDRYICDRFYP-NDL 227
Cdd:cd15072    82 TALASICSSAAIAWDRYHHYCT------RSKLQWSTAISlvLFVWLfSAFWAAMPLLGWGEYDYEPLGTCCTLDYSkGDR 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKghqKRKALktTVILILAFFACWLPYYIgISIDSFIlleiikqgc 307
Cdd:cd15072   156 NYVSYLFTMAFFNFILPLFILLTSYSSIEQKLKKEG---HLRFN--TGLPLLTLLICWGPYAI-LALYAAI--------- 220
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1127774881 308 EFENTVHKWISITEAL-AFFHCCLNPILYAFLGAKFK 343
Cdd:cd15072   221 TDVTSISPKLRMVPALlAKTSPTINAILYALGNENYR 257
7tmA_GPR176 cd15006
orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; ...
73-271 3.35e-07

orphan G protein-coupled receptor 176, member of the rhodopsin-like class A GPCR family; GPR176 is a putative G protein-coupled receptor that belongs to the class A GPCR superfamily; no endogenous ligand for GPR176 has yet been identified. The class A rhodopsin-like GPCRs represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320135 [Multi-domain]  Cd Length: 289  Bit Score: 51.41  E-value: 3.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAVDAVAN----WYFGNFLCKAVHV 147
Cdd:cd15006     1 FTTTVQVVIFVGSLLGNFMVLWSTCRTSVFKSVTNRFIKNLACSGICAsLVCVPFDIVLSASPhccwWIYTLLFCKVIKF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 148 IYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYvgVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDL 227
Cdd:cd15006    81 LHKVFCSVTVLSFAAIALDRYYSVLYPLERKISDAKSRDLVIY--IWAHAVVASVPVFAVTNVTDIYAMSTCTESWGYSL 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 228 WVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSkghQKRKAL 271
Cdd:cd15006   159 GHLVYVIIYNITTVILPVAVVFLFMILIRRALSAS---QKKKVI 199
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
80-340 7.16e-07

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 50.14  E-value: 7.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLI 159
Cdd:cd15106     9 IISLVGLTGNAVVLWLLGFRMR-RNAFSVYILNLAAADFLFLCCHIIDSLLRLINIFHIISIPKILTNVMTFPYFAGLSM 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 160 LAFISLDRYLAIVHAT--NSQRPRKLLAekVVYVGVWIPALLLTIPDFIFanvseaddryiCDRFYP--NDLWVVVFQFQ 235
Cdd:cd15106    88 LSAISTERCLSVLWPIwyRCHRPRHLSA--VVCVLLWALSLLLSILEWKF-----------CGFLFSgaDSHWCQTFDFI 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 236 HIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYyigiSIDSFILLEIIKQGCEFENTVHK 315
Cdd:cd15106   155 TTAWLIFLFVVLCGSSLALLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPF----GIQWFLLLWIHIDLEVLFCHVYL 230
                         250       260
                  ....*....|....*....|....*
gi 1127774881 316 wisITEALAFFHCCLNPILYAFLGA 340
Cdd:cd15106   231 ---VSVVLSCLNSSANPIIYFFVGS 252
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
80-344 1.19e-06

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 49.86  E-value: 1.19e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVI---TLPFwAVDAVANWYFGNFLCK----AVHVIYTVN 152
Cdd:cd15084    19 MVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLfgsSVSF-SNNIVGFFVFGKTMCEfegfMVSLTGIVG 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSsvliLAFISLDRYLAIVHATNSQR-PRKLLAEKVVYVGVWipALLLTIPDFI--FANVSEADDRYICDRFYP----N 225
Cdd:cd15084    98 LWS----LAILAFERYLVICKPMGDFRfQQRHAVSGCAFTWGW--SLLWTSPPLFgwSSYVPEGLRTSCGPNWYTggtnN 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 226 DLWVVVFqfqhIMVGLILPGIVILSCYCIIISKLSHSKGHQK---------RKALKTTVILILAFFACWLPYyigisiDS 296
Cdd:cd15084   172 NSYILAL----FVTCFALPLSTIIFSYSNLLLTLRAVAAQQKesettqraeKEVTRMVIAMVMAFLICWLPY------AT 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 297 FILLEIIKQGCEFENTVHKWISITEALAFFHcclNPILYAFLGAKFKT 344
Cdd:cd15084   242 FAMVVATNKDVVIQPTLASLPSYFSKTATVY---NPIIYVFMNKQFRS 286
7tmA_Encephalopsin cd15078
encephalopsins (opsin-3), member of the class A family of seven-transmembrane G ...
73-345 8.30e-06

encephalopsins (opsin-3), member of the class A family of seven-transmembrane G protein-coupled receptors; Encephalopsin, also called Opsin-3 or Panopsin, is a mammalian extra-retinal opsin that is highly localized in the brain. It is thought to play a role in encephalic photoreception. Encephalopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320206 [Multi-domain]  Cd Length: 279  Bit Score: 47.13  E-value: 8.30e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVAN-WYFGNFLCkaVHVIYT 150
Cdd:cd15078     2 LLALLIATIGFLGVCNNLLVLILYYKFKRLRTPTNLLLVNISLSDLLVSLLgVTFTFMSCVRGrWVFDVAGC--VWDGFS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYS--SVLILAFISLDRYLAIVHA--TNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFaNVSEADDRYICDRFYPND 226
Cdd:cd15078    80 NSLFGivSIMTLTVLAYERYIRVVHAkvVNFSWSWRAITYIWLYSLAWTGAPLLGWNRYTL-EVHGLGCSFDWKSKDPND 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFQFqhiMVGLILPGIVILSCYCII---ISKLSHSKGHQ----------KRKALKTTVILILAFFACWLPYYIgis 293
Cdd:cd15078   159 TSFVLLFF---LGCLVVPLGIMAYCYGHIlyeIRMLRSVEDLQtfqvikilkyEKKVAKMCLLMISTFLICWMPYAV--- 232
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 294 idsFILLEIIKQGcefeNTVHKWISITEAL-AFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15078   233 ---VSLLVTSGYS----KLVTPTIAIIPSLfAKSSTAYNPVIYIFMIRKFRQC 278
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
109-340 1.80e-05

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 46.16  E-value: 1.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 109 YRLHLSVADLLFVITLPFWAVDAVAN--WYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAE 186
Cdd:cd15169    39 YALNLGCSDLLLTVSLPLKAVEALASgaWPLPASLCPVFAVAHFAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYS 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 187 KVVYVGVWipALLLTIPDFIF-----------ANVS-----EADDRYIC-DRFYPNDLWVVVFQFQHIMvgLILPGIVIL 249
Cdd:cd15169   119 WGVCAAIW--ALVLCHLGLVFgleapggwldhSNTSlgintPVNGSPVClEAWDPASAGPARFSLSLLL--FFLPLAITA 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 250 SCYCIIISKLSHSKGHQKRKALKTTVI--LILAFFACWLPYYIGiSIDSFIlleiikqgceFENTVHKWISITEALAFFH 327
Cdd:cd15169   195 FCYVGCLRALARSGLTHRRKLRAAWVAggALLTLLLCVGPYNAS-NVASFL----------YPNLGGSWRKLGLITGAWS 263
                         250
                  ....*....|...
gi 1127774881 328 CCLNPILYAFLGA 340
Cdd:cd15169   264 VVLNPLVTGYLGR 276
7tmA_MWS_opsin cd15080
medium wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
80-344 1.93e-05

medium wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Medium Wave-Sensitive opsin, which mediates visual transduction in response to light at medium wavelengths (green). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 381742 [Multi-domain]  Cd Length: 280  Bit Score: 45.98  E-value: 1.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYF--GNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15080     9 LLILLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTMYTSMHGYFvfGPTGCNLEGFFATLGGEIAL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRprklLAEKVVYVGV---WIPALLLTIPDFIF--------ANVSEADDRYICDRFYPND 226
Cdd:cd15080    89 WSLVVLAIERYVVVCKPMSNFR----FGENHAIMGVaftWVMALACAAPPLVGwsryipegMQCSCGIDYYTLKPEVNNE 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVVVFqfqhIMVGLILPGIVILSCYCIIISKLSHSKGHQK---------RKALKTTVILILAFFACWLPYyigisiDSF 297
Cdd:cd15080   165 SFVIYM----FVVHFTIPLIVIFFCYGRLVCTVKEAAAQQQesattqkaeKEVTRMVIIMVIAFLICWVPY------ASV 234
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1127774881 298 ILLEIIKQGCEFENTvhkWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15080   235 AFYIFTHQGSDFGPI---FMTIPAFFAKSSAVYNPVIYILMNKQFRN 278
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
80-343 2.85e-05

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 45.50  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPF-WAVDAVANWYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15086     9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVcVLGTPFsFAASTQGRWLIGEHGCRWYGFANSLFGIVSL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 158 LILAFISLDRYLAIVHATNSQRP--RKLLaekVVYVGVWIPALLLTIPDFI-FANVSEADDRYICDRFY----PNDLWVV 230
Cdd:cd15086    89 ISLAVLSYERYCTLLRPTEADVSdyRKAW---LGVGGSWLYSLLWTLPPLLgWSSYGPEGPGTTCSVQWtsrsANSISYI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFQFqhiMVGLILPGIVILSCYCII------ISKLSHSKGhQKR--KALKTTVILILAFFACWLPYYIGISIDSFILLEI 302
Cdd:cd15086   166 ICLF---IFCLLLPFLVMVYCYGRLlyaikqVGKINKSTA-RKReqHVLLMVVTMVICYLLCWLPYGVMALLATFGKPGL 241
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1127774881 303 IKQGCEFentvhkwisITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15086   242 VTPVASI---------VPSILAKSSTVVNPIIYVFMNKQFY 273
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
80-340 2.99e-05

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 45.08  E-value: 2.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLY-SSVL 158
Cdd:cd15107     9 IIALVGLAGNAIVLWLLGFHMH-RNAFSVYILNLAGADFLFLCTQIVFSLEIVLQFHSIDIHIPLFLLTVTMFAYlAGLS 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIVHAT--NSQRPRKLLAekVVYVGVWIPALLLTIPDFIFANVSEAD-DRYICDRFypnDLWVVVFQFQ 235
Cdd:cd15107    88 MITAISIERCLSVMWPIwyHCQRPRHTSA--VICTLLWVLSLLLSLLEGKGCGFLFSTyDYYWCWTL---DLITTAWLIV 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 236 HIMVGLILPGIVILSCYCiiisklshskGHQK---RKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENT 312
Cdd:cd15107   163 LFVVLSGSSLALLVRIFC----------GSHRipvTRLYVTIALTVLVFLIFGLPFGIYWFLLKWIEEFYIVPCCGFYEV 232
                         250       260
                  ....*....|....*....|....*...
gi 1127774881 313 vhkwisiTEALAFFHCCLNPILYAFLGA 340
Cdd:cd15107   233 -------ILFLSCVNSCANPIIYFLVGS 253
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
72-346 3.01e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 45.23  E-value: 3.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIfltgivGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLfvITLPFWAVDAVANWYFGNFLCKAVHVI--Y 149
Cdd:cd15085     7 MFLNATFSIF------NNVLVIAVTLKNPQLRNPINIFILNLSFSDLM--MALCGTTIVTVTNYEGYFYLGDAFCIFqgF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLYS--SVLILAFISLDRYLAIVHAT-----NSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRF 222
Cdd:cd15085    79 AVNYFGivSLWSLTLLAYERYNVVCKPMgglklSTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGVQTSCSIGWEERS 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFqfqhIMVGLILPGIVILSCYCIIISKL-----------SHSKGHQKRKALKTTVILILAFFACWLPYYIg 291
Cdd:cd15085   159 WSNYSYLILY----FLMCFVIPVAIIGFSYGNVLRSLhklnkkieqqgGKNCPEEEERAVIMVLAMVIAFLICWLPYTV- 233
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 292 isidsFILLEIIKQGCEFE---NTVHKWISITEALaffhccLNPILYAFLGAKFKTSA 346
Cdd:cd15085   234 -----FALIVVVNPELSISplaATMPTYFAKTSPV------YNPIIYIFLNKQFRESA 280
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
81-344 4.16e-05

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 44.82  E-value: 4.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  81 IFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYF--GNFLCKAVHVIYTVNLYSSVL 158
Cdd:cd15077    10 LVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFvlGPLACKIEGFTATLGGMVSLW 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIVHATNSQRPRKLLAeKVVYVGVWIPALLLTIPDFIF--------ANVSEADDRYICDRFYPNDLWVV 230
Cdd:cd15077    90 SLAVVAFERFLVICKPLGNFTFRGTHA-IIGCIATWVFGLAASLPPLFGwsryipegLQCSCGPDWYTTNNKWNNESYVM 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 -VFQFqhimvGLILPGIVILSCYCIIISKL---------SHSKGHQKRKALKTTVILILAFFACWLPYyigisiDSFILL 300
Cdd:cd15077   169 fLFCF-----CFGVPLSIIVFSYGRLLLTLravakqqeqSASTQKAEREVTKMVVVMVLGFLVCWLPY------ASFALW 237
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 301 EIIKQGCEFEntvHKWISITEALAFFHCCLNPILYAFLGAKFKT 344
Cdd:cd15077   238 VVTNRGEPFD---LRLASIPSVFSKASTVYNPVIYVFMNKQFRS 278
7tmA_GPR12 cd15961
G protein-coupled receptor 12, member of the class A family of seven-transmembrane G ...
89-337 4.18e-05

G protein-coupled receptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3.


Pssm-ID: 320627 [Multi-domain]  Cd Length: 268  Bit Score: 44.63  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  89 NGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLpfwavdaVANWYFGNFLCKAVHVIYTVNLY-----SSVLILAFI 163
Cdd:cd15961    18 NAIVVLIIFQNPSLRAPMFLLIGSLALADLLAGIGL-------ILNFIFAYLLQSEAAKLVTVGLIvasfsASVCSLLAI 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 164 SLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEadDRYICDRFYP---NDLWVVVFQFQhIMVG 240
Cdd:cd15961    91 TVDRYLSLYYALTYNSERTVTFTYVMLVLLWGASICLGLLPVMGWNCLA--DESTCSVVRPltkNNAAILSVSFL-LMFA 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 241 LILPGIVILscyCIIISKLSHSKGHQ-----------KRKALKTTVILILAFFACWLPYYIGISIDSFILLEIikqgcef 309
Cdd:cd15961   168 LMLQLYIQI---CKIVMRHAHQIALQhhflatshyvtTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSI------- 237
                         250       260
                  ....*....|....*....|....*...
gi 1127774881 310 entvhkWISITEALAFFHCCLNPILYAF 337
Cdd:cd15961   238 ------YTYATLLPATYNSIINPVIYAF 259
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
79-203 8.97e-05

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 43.99  E-value: 8.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPF--WAVDAVANWYFGNFLCKAVHVIYTVNLYS 155
Cdd:cd15005     8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLrSLACFPFvmASVRHGSGWIYGALSCKVIAFLAVLFCFH 87
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1127774881 156 SVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP 203
Cdd:cd15005    88 SAFTLFCIAVTRYMAIAHHRFYAKRMTFWTCLAVICMAWTLSVAMAFP 135
7tmA_GPR37 cd15127
G protein-coupled receptor 37, member of the class A family of seven-transmembrane G ...
80-214 9.66e-05

G protein-coupled receptor 37, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR37, also called parkin-associated endothelin-like receptor (Pael-R), was isolated from a set of human brain frontal lobe expressed sequence tags. It is highly expressed in the mammalian CNS. It is a substrate of parkin and is involved in the pathogenesis of Parkinson's disease. GPR37 has recently been shown to act as a receptor for the neuropeptide prosaptide, the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also called sulfated glycoprotein-1). Both prosaptide and prosaposin protect primary astrocytes against oxidative stress. GPR37 is part of the class A family of GPCRs that includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320255 [Multi-domain]  Cd Length: 298  Bit Score: 43.69  E-value: 9.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV-ITLPFWAVDAVAN-WYFGNFLCKAVHVIYTVNLYSSV 157
Cdd:cd15127     9 VIFGIGIMGNVAVMCIVCHNYYMRSISNSLLANLAFWDFLIIfFCLPLVIFHELTKkWLLGDFSCKIVPYIEVASLGVTT 88
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1127774881 158 LILAFISLDRYLAivhATNSQRPRKLL----AEKVVYVGVWIPALLLTIPDFIFANVSEAD 214
Cdd:cd15127    89 FTLCALCIDRFRA---ATNVQMYYEMIenctSTTAKLAVIWVGALLLALPEVVLRQLSKED 146
7tmA_S1PR cd15102
sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...
151-337 1.03e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320230 [Multi-domain]  Cd Length: 270  Bit Score: 43.61  E-value: 1.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVH-----ATNSQRPRKLLAekvvyvGVWIPALLLTIPDFIFANVSEADDRyiCDRFYP- 224
Cdd:cd15102    81 VALSASVFSLLAIAIERHLTMAKmkpygASKTSRVLLLIG------ACWLISLLLGGLPILGWNCLGALDA--CSTVLPl 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 -NDLWVVvfqFQHIMVGLILPGIVILSC--YCII----ISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSF 297
Cdd:cd15102   153 ySKHYVL---FCVTIFAGILAAIVALYAriYCLVrasgRKATRASASPRSLALLKTVLIVLLVFIACWGPLFILLLLDVA 229
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1127774881 298 ILLeiikQGCEFENTVHKWIsiteALAFFHCCLNPILYAF 337
Cdd:cd15102   230 CPV----KTCPILYKADWFL----ALAVLNSALNPIIYTL 261
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
76-345 1.27e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 43.23  E-value: 1.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL---LFVITLPFWAVDAVANWYFGNFLCKAVHVIYTvn 152
Cdd:cd15070     5 SIEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIavgVLVIPLAIVVSLGVTIHFYSCLFMSCLLVVFT-- 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 lYSSVLILAFISLDRYLAIVHATnsqRPRKLLAEKVVYVGV---WIPALLLTI-PDF------IFANVSEADDRYICDRF 222
Cdd:cd15070    83 -HASIMSLLAIAVDRYLRVKLTV---RYRIVTTQRRIWLALglcWLVSFLVGLtPMFgwnrkpSLESVNTTPLQCQFTSV 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 223 YPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHS------KGHQKRKALKT--TVILILAFFA-CWLPyyigIS 293
Cdd:cd15070   159 MRMDYMVYFSFFTWILIPLVIMCALYVDIFYIIRNKLSQNatgfreTGAFYGREFKTakSLALVLFLFAvCWLP----LS 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1127774881 294 IDSFILLeiikqgceFENTVHK-WISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15070   235 IINCVVY--------FNPKVPKiALYLGILLSHANSMMNPIVYACKIKKFKET 279
7tmA_D1B_dopamine_R cd15319
D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G ...
76-290 3.21e-04

D1B (or D5) subtype dopamine receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320442 [Multi-domain]  Cd Length: 317  Bit Score: 42.25  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  76 TIYSIIFLTGIVGNGLVILVMGYQKKLRS-MTDKYRLHLSVADLLF-VITLPFWAVDAVAN-WYFGNFlCKAVHVIYTVN 152
Cdd:cd15319     5 CLLSLLILWTLLGNILVCAAVVRFRHLRSkVTNIFIVSLAVSDLFVaLLVMPWKAVAEVAGyWPFGAF-CDVWVAFDIMC 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 153 LYSSVLILAFISLDRYLAIvhaTNSQRPRKLLAEKVVYVGV---WIPALLLT-IPDFIFANVSEADDRYICDRFYPNDL- 227
Cdd:cd15319    84 STASILNLCVISVDRYWAI---SSPFRYERKMTQRVALVMIsvaWTLSVLISfIPVQLNWHKDSGDDWVGLHNSSISRQv 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 228 -------WVVVFQFQHIMVGLILPGIVILSCYCII----------ISKLSHSKGH----------------------QKR 268
Cdd:cd15319   161 eencdssLNRTYAISSSLISFYIPVAIMIVTYTRIyriaqiqirrISSLERAAEHaqscrsnridchhhtslrtsikKET 240
                         250       260
                  ....*....|....*....|..
gi 1127774881 269 KALKTTVILILAFFACWLPYYI 290
Cdd:cd15319   241 KVLKTLSVIMGVFVCCWLPFFI 262
7tmA_OR2T-like cd15421
olfactory receptor subfamily 2T and related proteins, member of the class A family of ...
73-173 4.55e-04

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320543  Cd Length: 277  Bit Score: 41.77  E-value: 4.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMGYQKKLRsmTDKYRL--HLSVADLLFV-ITLPFWAVDAVANWYFGNFL-CKAVHVI 148
Cdd:cd15421     2 FLFSLILLIFLVALTGNALLILLIWLDSRLH--TPMYFLlsQLSLMDLMLIsTTVPKMATNFLSGRKSISFVgCGTQIFF 79
                          90       100
                  ....*....|....*....|....*
gi 1127774881 149 YTVNLYSSVLILAFISLDRYLAIVH 173
Cdd:cd15421    80 FLTLGGAECLLLALMAYDRYVAICH 104
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
75-174 5.83e-04

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 41.33  E-value: 5.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  75 PTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRL--HLSVADLL-FVITLPFWAVDAVAN-WYFGNFLCKAVHVIYT 150
Cdd:cd15142     4 PTIPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLgTCLASPVTIATYLKGrWPGGQPLCEYFSFILL 83
                          90       100
                  ....*....|....*....|....
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHA 174
Cdd:cd15142    84 FFSLSGLSIICAMSIERYLAINHA 107
7tmA_TSH-R cd15964
thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family ...
73-343 6.22e-04

thyroid-stimulating hormone receptor (or thyrotropin receptor), member of the class A family of seven-transmembrane G protein-coupled receptors; The glycoprotein hormone receptors are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone family includes the three gonadotropins: luteinizing hormone (LH), follicle-stimulating hormone (FSH), chorionic gonadotropin (CG), and a pituitary thyroid-stimulating hormone (TSH). The glycoprotein hormones exert their biological functions by interacting with their cognate GPCRs. Both LH and CG bind to the same receptor, the luteinizing hormone-choriogonadotropin receptor (LHCGR); FSH binds to FSH-R and TSH to TSH-R. TSH-R plays an important role thyroid physiology, and its activation stimulates the production of thyroxine (T4) and triiodothyronine (T3). Defects in TSH-R are a cause of several types of hyperthyroidism. The receptor is predominantly found on the surface of the thyroid epithelial cells and couples to the G(s)-protein and activates adenylate cyclase, thereby promoting cAMP production. TSH and cAMP stimulate thyroid cell proliferation, differentiation, and function.


Pssm-ID: 320630 [Multi-domain]  Cd Length: 275  Bit Score: 41.04  E-value: 6.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIYSIIFLTGIVGNGLVILVMgyqkklrsMTDKYRL--------HLSVADLLFVITLPFWA-VDAVANWYFGNFL-- 141
Cdd:cd15964     2 FLRIVVWFVNLLAILGNVFVLLIL--------LTSHYKLtvprflmcNLAFADFCMGIYLLLIAsVDLHTRSEYYNHAid 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 142 ------CKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIfaNVSEADD 215
Cdd:cd15964    74 wqtgpgCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHASAIMLGGWVFCFLLALLPLV--GVSSYAK 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 216 RYIC---DRFYPNDLWVVVFqfqhIMVGLILPGIVILSCYC---IIISKLSHSKGHQKRKALKTTVILILAFFACWLPYy 289
Cdd:cd15964   152 VSIClpmDTETPLAQAYIVF----VLMLNIIAFVIICACYIkiyITVRNPQYKSGDKDTKIAKRMAVLIFTDFICMAPI- 226
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 290 igisidSFILLEIIKQgcefentvHKWISITEA---LAFFH---CCLNPILYAFLGAKFK 343
Cdd:cd15964   227 ------SFYALSAILN--------KPLITVSNSkilLVLFYplnSCANPFLYAIFTKAFR 272
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
74-342 9.28e-04

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 40.53  E-value: 9.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSII-FLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPF---------WAVdavanWYFGNFLCK 143
Cdd:cd14990     2 LSLLYLIIcFPVGLCYNALLVLVNLYNKASMTMPDVYFVNMAIAGLVLNAVAPVqllgpdntrWPL-----WNSNNEVYI 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 144 AVHVIYTVNLYSSVLILAFISLDRYLAIVhatnsqRPRKLLAE----KVVYVGVWIPALLLTIPDFIFanvseaddrYIC 219
Cdd:cd14990    77 TLLILFNVSSLVSMYSTTLLSLDYYIERA------LPRTYMSSvyntKHVCGFIWGGAVLTSFSSLLF---------YIC 141
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPNDLWVVVFQFQH----IMV--GLILPGIVILSCYCIII------SKLSHSKGHQKRKALKTTVILILAFFACWLP 287
Cdd:cd14990   142 SHVSTKIIECSKMQNKEaadaIMVfiGYVVPALAVLYALVLILrirkeaTPLDQDSGRLDPSAHRLLLATVCTQFLLWTP 221
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1127774881 288 YYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKF 342
Cdd:cd14990   222 YYMILLVHTVQASRGKKVDAGYLRVFHFLKGLSKLLAFSSSFVVPLLYRYMNKNF 276
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
72-343 9.95e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 40.53  E-value: 9.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVIT--LPFWAVDAVANWYFGNFLCkaVHVIY 149
Cdd:cd15075     1 TILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFggLLSVVTNAVGYFNLGRVGC--VLEGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNLY--SSVLILAFISLDRYLAIVH--ATNSQRPRKLLAEKVVyvgVWIPALLLTIPDFI--------FANVSEADDRY 217
Cdd:cd15075    79 AVAFFgiAALCTVAVIAVDRLFVVCKplGTLTFQTRHALAGIAS---SWLWSLIWNTPPLFgwgsyqleGVMTSCAPDWY 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 218 ICDrfyPNDLWVVVFQFqhiMVGLILPGIVILSCYCIIISKL----------SHSKGHQKRKALKTTVILILAFFACWLP 287
Cdd:cd15075   156 SRD---PVNVSYILCYF---SFCFAIPFAIILVSYGYLLWTLrqvaklgvaeGGSTAKAEVQVARMVVVMVMAFLLCWLP 229
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1127774881 288 YyigisiDSFILLEIIKQGCEFENTVHkwiSITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15075   230 Y------AAFALTVVSKPDVYINPLIA---TVPMYLAKSSTVYNPIIYIFMNKQFR 276
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
79-203 1.17e-03

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 40.40  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTGI--VGNGLVILVMGYQKKLRSMTDKYRLHLSVADLL-FVITLPFW--AVDAVANWYFGNFLCKAVHVIYTVNL 153
Cdd:cd15218     6 SLGFIIGVsvVGNLLISILLVKDKTLHRAPYYFLLDLCCSDILrSAICFPFVftSVKNGSTWTYGTLTCKVIAFLGVLSC 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIP 203
Cdd:cd15218    86 FHTAFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_GPR142 cd15129
G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G ...
73-346 1.49e-03

G-protein-coupled receptor GPR142, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR142, a vertebrate orphan receptor, is very closely related to GPR139, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and plays an important role in mediating enhancement of glucose-stimulated insulin secretion and maintaining glucose homeostasis, whereas GPR139 is expressed almost exclusively in the brain and is suggested to play a role in the control of locomotor activity. These orphan receptors are phylogenetically clustered with invertebrate FMRFamide receptors such as Drosophila melanogaster DrmFMRFa-R.


Pssm-ID: 320257 [Multi-domain]  Cd Length: 270  Bit Score: 40.15  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  73 FLPTIY-SIIFLTGIVGNGLVILVMgyqKKLRSMTDK----YRLHLSVADLL---FVITLPFWAVDAVANWYFGNFLCKA 144
Cdd:cd15129     1 VIPVIYySVLLCLGLPVNILTAVAL---SRLAVRTKKssyyYLLALTASDILtqvFIIFVGFILQTAILAREVPHALIHT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 145 VHVIYTVNLYSSVLILAFISLDRYLAIVH------ATNSQRPRKLLAekvvyvGVWIPALLLTIPDFIFANVSEADDryi 218
Cdd:cd15129    78 VSVLEFAANHASIWITVLLTVDRYVALCHplryraVSYPERTRRIIA------AVFVAALATGIPFYWWSDMWRDSH--- 148
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 219 cdrfyPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKL---SHSKGHQKRKAlKTTVIL--ILAFFAC-WLPYYIgi 292
Cdd:cd15129   149 -----PPTTLDKVLKWTHCFIIYFIPCTIFLVTNSVIIHKLrrrKGRSGPQRRSG-KTTAILlaITTVFAVlWAPRTV-- 220
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 293 sidsFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSA 346
Cdd:cd15129   221 ----VIIYHLYVSSVNRDWRVHLALDLANMLAMLNTAVNFFLYCFVSKRFRRTV 270
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
77-345 1.54e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 40.22  E-value: 1.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  77 IYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADL---LFVITLPFWAVDAVANWYFGnflCKAVHVIYTVNL 153
Cdd:cd15071     6 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVavgALVIPLAIIINIGPQTEFYS---CLMVACPVLILT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 154 YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTI-PDFIFANVSEADDRYICDRFYPNdlWVVVF 232
Cdd:cd15071    83 QSSILALLAIAVDRYLRVKIPTRYKSVVTPRRAAVAIAGCWILSFLVGLtPMFGWNNLNAVERAWAANSSMGE--LVIKC 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 QFQHI-----MV-----GLILPG-----IVILSCYCIIISKL-----SHS----KGHQKRKALKTTVILILAFFA-CWLP 287
Cdd:cd15071   161 QFETVismeyMVyfnffVWVLPPlllmlLIYLEVFYLIRKQLnkkvsSSSsdpqKYYGKELKIAKSLALILFLFAlSWLP 240
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1127774881 288 YYIgisidsfilLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15071   241 LHI---------LNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFRTT 289
7tm_classB cd13952
class B family of seven-transmembrane G protein-coupled receptors; The class B of ...
79-303 1.66e-03

class B family of seven-transmembrane G protein-coupled receptors; The class B of seven-transmembrane GPCRs is classified into three major subfamilies: subfamily B1 (secretin-like receptor family), B2 (adhesion family), and B3 (Methuselah-like family). The class B receptors have been identified in all the vertebrates, from fishes to mammals, as well as invertebrates including Caenorhabditis elegans and Drosophila melanogaster, but are not present in plants, fungi or prokaryotes. The B1 subfamily comprises receptors for polypeptide hormones of 27-141 amino-acid residues such as secretin, glucagon, glucagon-like peptide (GLP), calcitonin gene-related peptide, parathyroid hormone (PTH), and corticotropin-releasing factor. These receptors contain the large N-terminal extracellular domain (ECD), which plays a critical role in hormone recognition by binding to the C-terminal portion of the peptide. On the other hand, the N-terminal segment of the hormone induces receptor activation by interacting with the receptor transmembrane domains and connecting extracellular loops, triggering intracellular signaling pathways. All members of the subfamily B1 receptors preferentially couple to G proteins of G(s) family, which positively stimulate adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. The subfamily B2 consists of cell-adhesion receptors with 33 members in humans and vertebrates. The adhesion receptors are characterized by the presence of large N-terminal extracellular domains containing a variety of structural motifs, which play critical roles in cell-cell adhesion and cell-matrix interactions, linked to a class B seven-transmembrane domain. These include, for example, EGF (epidermal growth factor)-like domains in CD97, Celsr1 (cadherin family member), Celsr2, Celsr3, EMR1 (EGF-module-containing mucin-like hormone receptor-like 1), EMR2, EMR3, and Flamingo; two laminin A G-type repeats and nine cadherin domains in Flamingo and its human orthologs Celsr1, Celsr2 and Celsr3; olfactomedin-like domains in the latrotoxin receptors; and five or four thrombospondin type 1 repeats in BAI1 (brain-specific angiogenesis inhibitor 1), BAI2 and BAI3. Almost all adhesion receptors, except GPR123, contain an evolutionarily conserved GPCR- autoproteolysis inducing (GAIN) domain that undergoes autoproteolytic processing at the GPCR proteolysis site (GPS) motif located immediately N-terminal to the first transmembrane region, to generate N- and C-terminal fragments (NTF and CTF), which may serve important biological functions. Furthermore, the subfamily B3 includes Methuselah (Mth) protein, which was originally identified in Drosophila as a GPCR affecting stress resistance and aging, and its closely related proteins.


Pssm-ID: 410627 [Multi-domain]  Cd Length: 260  Bit Score: 39.89  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  79 SIIFLTgivgngLVILVMGYQKKLRSMTDKYRLHLSVAdllFVITLPFWAVDAVANWYFGNFLCKAVHVIytvnLYSSVL 158
Cdd:cd13952    15 SLVGLL------LTIITYLLFPKLRNLRGKILINLCLS---LLLAQLLFLIGQLLTSSDRPVLCKALAIL----LHYFLL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 iLAF-----ISLDRYLAIVHATNSQRPRKLLaekVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRF-YPNDLWvvvf 232
Cdd:cd13952    82 -ASFfwmlvEAFDLYRTFVKVFGSSERRRFL---KYSLYGWGLPLLIVIITAIVDFSLYGPSPGYGGEYcWLSNGN---- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 233 qfqHIMVGLILPGIVILSC----YCIIISKL--------SHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILL 300
Cdd:cd13952   154 ---ALLWAFYGPVLLILLVnlvfFILTVRILlrklretpKQSERKSDRKQLRAYLKLFPLMGLTWIFGILAPFVGGSLVF 230

                  ...
gi 1127774881 301 EII 303
Cdd:cd13952   231 WYL 233
7tmA_GPR3_GPR6_GPR12-like cd15100
G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of ...
89-290 2.65e-03

G protein-coupled receptors 3, 6, 12, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR3, GPR6, and GPR12 form a subfamily of constitutively active G-protein coupled receptors with dual coupling to G(s) and G(i) proteins. These three orphan receptors are involved in the regulation of cell proliferation and survival, neurite outgrowth, cell clustering, and maintenance of meiotic prophase arrest. They constitutively activate adenylate cyclase to a similar degree as that seen with fully activated G(s)-coupled receptors, and are also able to constitutively activate inhibitory G(i/o) proteins. Lysophospholipids such as sphingosine 1-phosphate (S1P) and sphingosylphosphorylcholine have been detected as the high-affinity ligands for Gpr6 and Gpr12, respectively, which show high sequence homology with GPR3. Also included in this subfamily is GPRx, also known as GPR185, which involved in the maintenance of meiotic arrest in frog oocytes.


Pssm-ID: 320228 [Multi-domain]  Cd Length: 268  Bit Score: 39.38  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  89 NGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLpfwAVDAVANWYFGNFLCKAVHVIYTVNLYS-SVLILAFISLDR 167
Cdd:cd15100    18 NAIVVAIIFSTPSLRAPMFLLIGSLALADLLAGLGL---ILHFVFRYCVYSEALSLVSVGLLVAAFSaSVCSLLAITVDR 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 168 YLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVseADDRYICDRFYP---NDLWVVVFQFqHIMVGLILP 244
Cdd:cd15100    95 YLSLYNALTYYSERTLTFTYVMLALLWTLALGLGLLPVLGWNC--LREGSSCSVVRPltkNHLAVLAVAF-LLVFALMLQ 171
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 245 GIVILscyCIIISKLSHSKGHQK-----------RKALKTTVILILAFFACWLPYYI 290
Cdd:cd15100   172 LYAQI---CRIVLRHAHQIALQRhflapshyvatRKGVSTLALILGTFAACWIPFAV 225
7tmA_MrgprG cd15111
mas-related G protein-coupled receptor subtype G, member of the class A family of ...
80-201 2.69e-03

mas-related G protein-coupled receptor subtype G, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320239  Cd Length: 263  Bit Score: 39.00  E-value: 2.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYssvlI 159
Cdd:cd15111     9 IVSLAGLVGNGLVLWHLGFHIK-KGPFSNYLLHLAAADFLFLSCQVGFSIAQAALGSEDTLYFVVTFLWFAAGLW----L 83
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1127774881 160 LAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVW---IPALLLT 201
Cdd:cd15111    84 LAAFSVERCLSYLFPACCQGCRPRWTSAVLCAVVWvltLPAVLLP 128
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
81-345 2.85e-03

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 39.15  E-value: 2.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  81 IFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLF-VITLPFWAvdAVANWYFGNFL-CKAVHVIYTVNLYSSVL 158
Cdd:cd15068    10 IAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFAI--TISTGFCAACHgCLFIACFVLVLTQSSIF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 159 ILAFISLDRYLAIV------HATNSQRPRKLLA---EKVVYVGV-----WIPALLLTIPDFIFANVSEADDRYICDRFYP 224
Cdd:cd15068    88 SLLAIAIDRYIAIRiplrynGLVTGTRAKGIIAicwVLSFAIGLtpmlgWNNCGQPKEGKNHSQGCGEGQVACLFEDVVP 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 225 NDlWVVVFQFqhiMVGLILPGIVILSCYCIIISKLSHSKGHQKRKAL----------------KTTVILILAFFACWLPY 288
Cdd:cd15068   168 MN-YMVYFNF---FACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLpgerarstlqkevhaaKSLAIIVGLFALCWLPL 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1127774881 289 YIgisIDSFILLeiiKQGCEFENTVHKWISITeaLAFFHCCLNPILYAFLGAKFKTS 345
Cdd:cd15068   244 HI---INCFTFF---CPDCSHAPLWLMYLAIV--LSHTNSVVNPFIYAYRIREFRQT 292
7tmA_GPBAR1 cd15905
G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G ...
86-292 3.52e-03

G protein-coupled bile acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G-protein coupled bile acid receptor GPBAR1 is also known as BG37, TGR5 (Takeda G-protein-coupled receptor 5), M-BAR (membrane-type receptor for bile acids), and GPR131. GPBAR1 is highly expressed in the gastrointestinal tract, but also found at many other tissues including liver, colon, heart, skeletal muscle, and brown adipose tissue. GPBAR1 functions as a membrane-bound receptor specific for bile acids, which are the end products of cholesterol metabolism that facilitate digestion and absorption of lipids or fat-soluble vitamins. Bile acids act as liver-specific metabolic signaling molecules and stimulate liver regeneration by activating GPBAR1 and nuclear receptors such as the farnesoid X receptor (FXR). Upon bile acids binding, GPBAR1 activation causes release of the G-alpha(s) subunit and activation of adenylate cyclase. The increase in intracellular cAMP level then stimulates the expression of many genes via the PKA-mediated phosphorylation of cAMP-response element binding protein (CREB). Thus, GPAR1-signalling exerts various biological effects in immune cells, liver, and metabolic tissues. For example, GPBAR1 activation leads to enhanced energy expenditure in brown adipose tissue and skeletal muscle; stimulation of glucagon-like peptide-1 (GLP-1) production in enteroendocrine L-cells; and inhibition of pro-inflammatory cytokine production in macrophages and attenuation of atherosclerosis development. GPBAR1 is a member of the class A rhodopsin-like family of GPCRs, which comprises receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands.


Pssm-ID: 320571 [Multi-domain]  Cd Length: 272  Bit Score: 38.97  E-value: 3.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  86 IVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAvdavANWY---FGNFLCKAVHVIYTVNLYSSVLILAF 162
Cdd:cd15905    13 IFANLFIILGIACNRKLHNTANYFFLSLLLADLLTGVALPFIP----GMSNesrRGYHSCLFVYVAPNFLFLSFLANLLM 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 163 ISLDRYLAIV---HATNSQRPRKL-LAEKVVYVGvwiPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFqfqhim 238
Cdd:cd15905    89 VHYERYLCIVyplQYHNFWVHRWVpLALLLTWAL---PLLFACLPALGWNNWTPGSNCSYKQVFPAAYIYLEVY------ 159
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1127774881 239 vGLILPGIVILSCYCII-----------ISKLSHSKGHQKRKAL---------KTTVILILAFFACWLPYYIGI 292
Cdd:cd15905   160 -GLVLPSILAIAFMSVRvlavarrqlqdICKLLRAVQRDGPSELeqqlnlryaKCIAGVSLTFLVCWVPYIAYL 232
7tmA_GPR26_GPR78-like cd15219
G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G ...
80-343 3.81e-03

G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan G-protein coupled receptor 26 (GPR26) and GPR78 are constitutively active and coupled to increased cAMP formation. They are closely related based on sequence homology and comprise a conserved subgroup within the class A G-protein coupled receptor (GPCR) superfamily. Both receptors are widely expressed in selected tissues of the brain but their endogenous ligands are unknown. GPR26 knockout mice showed increased levels of anxiety- and depression-like behaviors, whereas GPR78 has been implicated in susceptibility to bipolar affective disorder and schizophrenia. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320347 [Multi-domain]  Cd Length: 264  Bit Score: 38.59  E-value: 3.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  80 IIFLTGIVGNGLVILVMGYQKKLRSMTDK-YRLHLSVADLLF-VITLPFWAVDAVANWY-FGNFLCKAVHVIYTVNLYSS 156
Cdd:cd15219     8 VVLVVSLLSNLLVLLCFLYSAELRKQVPGiFLLNLSFCNLLLtVLNMPFTLLGVVRNRQpFGDGFCQAVGFLETFLTSNA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 157 VLILAFISLDRYLAIVHA---TNSQRPRkllaEKVVYVG-VWI-------PALLLTIPDF--IFANVS----EADDRyic 219
Cdd:cd15219    88 MLSMAALSIDRWIAVVFPlsyTSKMRYR----DAALMVGySWLhsltfslVALFLSWLGYssLYASCTlhlpREEER--- 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 220 DRFYPndlWVVVFQFQHIMVGLilpgiVILSCYCIIISKLshskgHQKRKALKTTVILILAFFACWLPYYIGISIDSFIL 299
Cdd:cd15219   161 RRFAV---FTAFFHAFTFLLSL-----LVLCVTYLKVLKV-----RRRQRATKKISIFIGTFVLCFAPYVITRLVELLPF 227
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1127774881 300 LEIIKQgcefentvhkWISITEALAFFHCCLNPILYAFLGAKFK 343
Cdd:cd15219   228 VTINRY----------WGIVSKCLTYSKAASDPFVYSLLRQQYR 261
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
151-337 6.20e-03

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 38.23  E-value: 6.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 151 VNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRyiCDRFYPNDLWVV 230
Cdd:cd15349    81 TALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRS--CSSLLPLYSKSY 158
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 231 VFqFQHIMVGLILPGIVILSC--YCIIISKLSHS-KGHQKRKA---LKTTVILILAFFACWLPYYIGISIDSFILleiiK 304
Cdd:cd15349   159 IL-FCLVIFFIILLTIIGLYFaiYCLVRASGQRViSARSRRRSlrlLKTVLMILGAFMVCWGPLFILLLVDFFCS----S 233
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1127774881 305 QGCEFENTVhKWISiteALAFFHCCLNPILYAF 337
Cdd:cd15349   234 RSCKPLFGM-EWVL---ALAVLNSAINPLIYSF 262
7tmA_OR13-like cd15232
olfactory receptor family 13 and related proteins, member of the class A family of ...
72-173 7.26e-03

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.


Pssm-ID: 320360 [Multi-domain]  Cd Length: 270  Bit Score: 38.01  E-value: 7.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  72 IFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFV-ITLP-----FWAVDAVANwYFGnflCKAV 145
Cdd:cd15232     1 VLLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTsTVVPkllqnLLTERKTIS-FGG---CMAQ 76
                          90       100
                  ....*....|....*....|....*...
gi 1127774881 146 HVIYTVNLYSSVLILAFISLDRYLAIVH 173
Cdd:cd15232    77 LYFFTWSLGSELLLLTAMAYDRYVAICH 104
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
74-340 7.95e-03

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 37.80  E-value: 7.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIF-LTGIVGNGLVILVMGYQKKlRSMTDKYRLHLSVADLLFVIT-LPFWAVDAVANWYFGNFLCKAVHVIYTV 151
Cdd:cd15105     2 IPNLMIIIFgLVGLTGNAIVFWLLGFRLH-RNAFSVYILNLALADFLFLLChIIDSTLLLLKVFYPNIIFLPCFYTIMMV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 152 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDfifanvseaddRYICDRFYPNDLWVVV 231
Cdd:cd15105    81 LYITGLSMLSAISTERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILN-----------RYFCGFLDTKYENDSV 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 232 FQFQHIMVGLILPGIVILSCYC--IIISKLSHSKGHQKRKALKTTVIL-ILAFFACWLPYyigiSIDSFILLEIIKQGCE 308
Cdd:cd15105   150 CLASNFFTAAYLMFLFVVLCLSslALLARLFCGAGQMKLTRLYVTIMLtVLVFLLCGLPF----GIYWFLLFWIKDDFHV 225
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1127774881 309 FEntvHKWISITEALAFFHCCLNPILYAFLGA 340
Cdd:cd15105   226 LD---YGLYLASVVLTAVNSCANPIIYFFVGS 254
7tmA_LWS_opsin cd15081
long wave-sensitive opsins, member of the class A family of seven-transmembrane G ...
74-288 9.39e-03

long wave-sensitive opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Long Wave-Sensitive opsin is also called red-sensitive opsin or red cone photoreceptor pigment, which mediates visual transduction in response to light at long wavelengths. Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320209 [Multi-domain]  Cd Length: 292  Bit Score: 37.58  E-value: 9.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881  74 LPTIYSIIFLTGIV-GNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVItlpFWAVDAVANWYFGNFLCKAVHVI---Y 149
Cdd:cd15081    14 LTSVWMIFVVFASVfTNGLVLVATLKFKKLRHPLNWILVNLAIADLGETV---IASTISVVNQIFGYFILGHPMCVlegF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 150 TVNL--YSSVLILAFISLDRYLAIVHA-TNSQRPRKLLAEKVVYVGVWiPALLLTIPDFIFAnvseaddryicdRFYPND 226
Cdd:cd15081    91 TVSVcgITGLWSLTIISWERWVVVCKPfGNIKFDGKLAIVGIIFSWVW-SAVWCAPPIFGWS------------RYWPHG 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1127774881 227 LWVV----VFQ------FQHIMVGL-----ILPGIVILSCYCIII---------SKLSHSKGHQKRKALKTTVILILAFF 282
Cdd:cd15081   158 LKTScgpdVFSgssdpgVQSYMIVLmitccIIPLAIIILCYLQVWlairavaqqQKESESTQKAEKEVSRMVVVMIFAYC 237

                  ....*.
gi 1127774881 283 ACWLPY 288
Cdd:cd15081   238 FCWGPY 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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