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Conserved domains on  [gi|1126167814|ref|XP_019615786|]
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PREDICTED: conserved oligomeric Golgi complex subunit 5-like [Branchiostoma belcheri]

Protein Classification

conserved oligomeric Golgi complex subunit 5( domain architecture ID 10564031)

conserved oligomeric Golgi complex subunit 5 (COG5) is a component of the conserved oligomeric Golgi complex (COG), and is required for normal Golgi function

Gene Ontology:  GO:0070085|GO:0007030|GO:0048219|GO:0006891|GO:0015031

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 23-146 5.77e-31

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


:

Pssm-ID: 192566  Cd Length: 132  Bit Score: 118.18  E-value: 5.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126167814  23 PFLRAEFDAKTHANDVLHHGIA-------ISQQLAKLNEGINLLDRELHSQVVARHEDLLVQATGIESLEGVLQMMQTRI 95
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNnddtpldLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1126167814  96 TNLQAAVDRIRTKIADPCNKITSRTAQLARLQAACDLLRRIIRILYLSRRL 146
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 23-146 5.77e-31

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 118.18  E-value: 5.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126167814  23 PFLRAEFDAKTHANDVLHHGIA-------ISQQLAKLNEGINLLDRELHSQVVARHEDLLVQATGIESLEGVLQMMQTRI 95
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNnddtpldLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1126167814  96 TNLQAAVDRIRTKIADPCNKITSRTAQLARLQAACDLLRRIIRILYLSRRL 146
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
 
Name Accession Description Interval E-value
COG5 pfam10392
Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein ...
 23-146 5.77e-31

Golgi transport complex subunit 5; The COG complex, the peripheral membrane oligomeric protein complex involved in intra-Golgi protein trafficking, consists of eight subunits arranged in two lobes bridged by Cog1. Cog5 is in the smaller, B lobe, bound in with Cog6-8, and is itself bound to Cog1 as well as, strongly, to Cog7.


Pssm-ID: 192566  Cd Length: 132  Bit Score: 118.18  E-value: 5.77e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126167814  23 PFLRAEFDAKTHANDVLHHGIA-------ISQQLAKLNEGINLLDRELHSQVVARHEDLLVQATGIESLEGVLQMMQTRI 95
Cdd:pfam10392   2 AFLDPDFDPKSFANALLLATNNnddtpldLSTPLKRLNYDIQELDRRIRTLITSNHLELLSHLSSIKSASSILSTLKSSL 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1126167814  96 TNLQAAVDRIRTKIADPCNKITSRTAQLARLQAACDLLRRIIRILYLSRRL 146
Cdd:pfam10392  82 EYLSASYERLKSDVLEPYERALKLQSALKRLHQTTDLLRALLRFLHLSRQL 132
Vps51 pfam08700
Vps51/Vps67; This family includes a presumed domain found in a number of components of ...
 29-106 8.61e-07

Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.


Pssm-ID: 462568  Cd Length: 86  Bit Score: 47.66  E-value: 8.61e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1126167814  29 FDAKTHANDVL-HHGIA-ISQQLAKLNEGINLLDRELHSQVVARHEDLLVQATGIESLEGVLQMMQTRITNLQAAVDRIR 106
Cdd:pfam08700   6 FDADRYVSELLsKATLEeLLQFESSLRSEIERLDSELKQLVYDNYRDLIKAADTISKMKSEMEQLSQKLSELKQALSKIA 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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