NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1125730593|ref|WP_075058863|]
View 

MULTISPECIES: ATP-binding protein [Bacillus]

Protein Classification

ATP-binding protein( domain architecture ID 11482495)

ATP-binding protein with an AAA (ATPases Associated with various cellular Activities) domain, similar to magnesium-chelatase subunit ChlI and RuvB-like helicase 1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-313 1.69e-164

hypothetical protein; Provisional


:

Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 458.09  E-value: 1.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593   7 VSIDTAFQTIMQELRERSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  87 vctpdkasewkdtysKQCECVRRKKIARLMAASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 167 IALLGQPGSGKTHLLTAIMNNLIKKKSVHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRATDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125730593 247 QVEQIQSVLNYRYLNHKPLLISSELTIDEILDIDEALGSRIHQMCRDYIVIIRGDRMQLNHRLGDWE 313
Cdd:PRK06921  200 QIEQMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHRLEGER 266
 
Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-313 1.69e-164

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 458.09  E-value: 1.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593   7 VSIDTAFQTIMQELRERSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  87 vctpdkasewkdtysKQCECVRRKKIARLMAASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 167 IALLGQPGSGKTHLLTAIMNNLIKKKSVHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRATDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125730593 247 QVEQIQSVLNYRYLNHKPLLISSELTIDEILDIDEALGSRIHQMCRDYIVIIRGDRMQLNHRLGDWE 313
Cdd:PRK06921  200 QIEQMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHRLEGER 266
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
63-308 3.38e-17

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 79.05  E-value: 3.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  63 HLDEQLDLMVPDDMvSEDDFLLGKVctpdkasewkdtyskQCECVRR--KKIARLMAASGITEE--FEKLLFgNFITDGK 138
Cdd:COG1484    21 ALDELLAQAACDEL-SYEEFLALLL---------------EAEVAEReqRRIERRLKAARFPAAktLEDFDF-DAQPGLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 139 PDMIKDAYECaveyykDFqkIkgERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVhcMYFPYVEGMGDLK-ANFDN-L 215
Cdd:COG1484    84 RRQILELATL------DF--I--ERGENLILLGPPGTGKTHLAIALGHEACRAgYRV--RFTTAPDLVNELKeARADGrL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 216 EAKLDAMRKVEVLFIDDL-FKPIngqpraTDWQVEQIQSVLNYRYlNHKPLLISSELTIDEILDI--DEALGS----RIH 288
Cdd:COG1484   152 ERLLKRLAKVDLLILDELgYLPL------DAEGAELLFELISDRY-ERRSTIITSNLPFSEWGEVfgDPTLATaildRLV 224

                         250       260
                  ....*....|....*....|
gi 1125730593 289 QMCrdYIVIIRGDRMQLNHR 308
Cdd:COG1484   225 HHA--HIIELKGESYRLKEA 242
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 157-288 6.56e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.77  E-value: 6.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 157 QKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK------SVHCMYFPYVEGMGDLKANFDNLEAKLdAMRKVEVLFI 230
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGapflylNASDLLEGLVVAELFGHFLVRLLFELA-EKAKPGVLFI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125730593 231 DDlfkpINGQPRATDWQVEQIQSVLNYRYLNHKPLLI----SSELTIDEILDIDEALGSRIH 288
Cdd:cd00009    91 DE----IDSLSRGAQNALLRVLETLNDLRIDRENVRVigatNRPLLGDLDRALYDRLDIRIV 148
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 162-309 1.67e-06

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 48.21  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 162 ERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVhcmYFPYVEGM-GDLKANFDN--LEAKLDAMRKVEVLFIDDL-FKP 236
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAgYSV---RFTSAADLvNQLKRAHGDgkLTRKLQQLLKPDVLILDEWgYLP 166

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1125730593 237 INGQPRATDWQveqiqsVLNYRYlNHKPLLISSELTIDEILDI--DEALGS----RIHQMCrdYIVIIRGDRMQLNHRL 309
Cdd:pfam01695 167 LDQAEANLLFQ------VISKRY-EHRSIILTSNLPFGEWGQVfgDAVLATaildRLLHHC--HIVPIKGESYRLKTKS 236
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 163-287 1.21e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 44.67  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  163 RQNSIALLGQPGSGKTHLLTAIMNNLIKKK-----------------SVHCMYFPYVEGMGDLKANFDNLEAKLDAmRKV 225
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggviyidgedileevldQLLLIIVGGKKASGSGELRLRLALALARK-LKP 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125730593  226 EVLFIDDLFKPINGQPRATDWQVEQIQSVLNYRYLNHKPLLISSELTIDEILDIDEALGSRI 287
Cdd:smart00382  80 DVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRR 141
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 171-286 5.11e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 41.36  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 171 GQPGSGKTHLLTAIMNNLIKKKS------VHCMYF--PYVEGMgdLKANFDNLEAKLdamRKVEVLFIDDL-FkpINGQp 241
Cdd:TIGR00362 144 GGVGLGKTHLLHAIGNEILENNPnakvlyVSSEKFtnDFVNAL--RNNKMEEFKEKY---RSVDLLLIDDIqF--LAGK- 215

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1125730593 242 ratdwqvEQIQ----SVLNYRYLNHKPLLISSELTIDEILDIDEALGSR 286
Cdd:TIGR00362 216 -------ERTQeeffHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSR 257
 
Name Accession Description Interval E-value
PRK06921 PRK06921
hypothetical protein; Provisional
 7-313 1.69e-164

hypothetical protein; Provisional


Pssm-ID: 180750 [Multi-domain]  Cd Length: 266  Bit Score: 458.09  E-value: 1.69e-164
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593   7 VSIDTAFQTIMQELRERSArfLGTKQAVSEEKAEFDCPYCKDRGIVVYRVHKDTSWhldeqldlmvpddmvseddfllgk 86
Cdd:PRK06921    1 MTKRTIEEKAAELLMRERP--STTTKPEESDAERYDCPKCKDRGIIIYRRNTAEVW------------------------ 54

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  87 vctpdkasewkdtysKQCECVRRKKIARLMAASGITEEFEKLLFGNFITDGKPDMIKDAYECAVEYYKDFQKIKGERQNS 166
Cdd:PRK06921   55 ---------------RQCECVEQRKIERLLKASEITEAFRKLTFKNFKTEGKPQAIKDAYECAVEYVKDFEKIQESRKNS 119

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 167 IALLGQPGSGKTHLLTAIMNNLIKKKSVHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVLFIDDLFKPINGQPRATDW 246
Cdd:PRK06921  120 IALLGQPGSGKTHLLTAAANELMRKKGVPVLYFPFVEGFGDLKDDFDLLEAKLNRMKKVEVLFIDDLFKPVNGKPRATEW 199

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125730593 247 QVEQIQSVLNYRYLNHKPLLISSELTIDEILDIDEALGSRIHQMCRDYIVIIRGDRMQLNHRLGDWE 313
Cdd:PRK06921  200 QIEQMYSVLNYRYLNHKPILISSELTIDELLDIDEALGSRIVEMCKDYLVIIKGDSFELNHRLEGER 266
PRK08116 PRK08116
hypothetical protein; Validated
 104-309 1.29e-24

hypothetical protein; Validated


Pssm-ID: 236153 [Multi-domain]  Cd Length: 268  Bit Score: 100.10  E-value: 1.29e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 104 CECVRRK---------------KIARLMAASGITEEFEKLLFGNFITDGKPDmikDAYECAVEYYKDFQKIKGErqnSIA 168
Cdd:PRK08116   43 CECEREAeeakereeenrekqrRIERLKSNSLLDEKFRNSTFENFLFDKGSE---KAYKIARKYVKKFEEMKKE---NVG 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 169 LL--GQPGSGKTHLLTAIMNNLIKKK-SVHCMYFPYVegMGDLKANF-----DNLEAKLDAMRKVEVLFIDDLfkpinGQ 240
Cdd:PRK08116  117 LLlwGSVGTGKTYLAACIANELIEKGvPVIFVNFPQL--LNRIKSTYkssgkEDENEIIRSLVNADLLILDDL-----GA 189

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125730593 241 PRATDWQVEQIQSVLNYRYLNHKPLLISSELTIDEILD-IDEALGSRIHQMC-------RDYIVIIRGDRMQLNHRL 309
Cdd:PRK08116  190 ERDTEWAREKVYNIIDSRYRKGLPTIVTTNLSLEELKNqYGKRIYDRILEMCtpvenegKSYRKEIAKEKLQRLKEL 266
DnaC COG1484
DNA replication protein DnaC [Replication, recombination and repair];
63-308 3.38e-17

DNA replication protein DnaC [Replication, recombination and repair];


Pssm-ID: 441093 [Multi-domain]  Cd Length: 242  Bit Score: 79.05  E-value: 3.38e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  63 HLDEQLDLMVPDDMvSEDDFLLGKVctpdkasewkdtyskQCECVRR--KKIARLMAASGITEE--FEKLLFgNFITDGK 138
Cdd:COG1484    21 ALDELLAQAACDEL-SYEEFLALLL---------------EAEVAEReqRRIERRLKAARFPAAktLEDFDF-DAQPGLD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 139 PDMIKDAYECaveyykDFqkIkgERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVhcMYFPYVEGMGDLK-ANFDN-L 215
Cdd:COG1484    84 RRQILELATL------DF--I--ERGENLILLGPPGTGKTHLAIALGHEACRAgYRV--RFTTAPDLVNELKeARADGrL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 216 EAKLDAMRKVEVLFIDDL-FKPIngqpraTDWQVEQIQSVLNYRYlNHKPLLISSELTIDEILDI--DEALGS----RIH 288
Cdd:COG1484   152 ERLLKRLAKVDLLILDELgYLPL------DAEGAELLFELISDRY-ERRSTIITSNLPFSEWGEVfgDPTLATaildRLV 224

                         250       260
                  ....*....|....*....|
gi 1125730593 289 QMCrdYIVIIRGDRMQLNHR 308
Cdd:COG1484   225 HHA--HIIELKGESYRLKEA 242
PRK06835 PRK06835
DNA replication protein DnaC; Validated
 97-288 7.25e-17

DNA replication protein DnaC; Validated


Pssm-ID: 235871 [Multi-domain]  Cd Length: 329  Bit Score: 79.56  E-value: 7.25e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  97 KDT-YS--KQCECVRRKKIARLMAASGITEEFEKLLFGNF--------ITDGKPDMIKDAYECAVEYYKDFQKIKGERQN 165
Cdd:PRK06835  105 KDTgFIngKKCSCYKQKLINLYYKQSNLKEILKEENFSNFnlnyysdeKDDDEPLSPRKNMEKILEKCKNFIENFDKNNE 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 166 SIALLGQPGSGKTHLLTAIMNNLIKK-KSVhcMYFPYVEGMGDLKA----NFDNLEAKLDAMRKVEVLFIDDLfkpinGQ 240
Cdd:PRK06835  185 NLLFYGNTGTGKTFLSNCIAKELLDRgKSV--IYRTADELIEILREirfnNDKELEEVYDLLINCDLLIIDDL-----GT 257

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1125730593 241 PRATDWQVEQIQSVLNYRYLNHKPLLISSELTIDEILDI-DEALGSRIH 288
Cdd:PRK06835  258 EKITEFSKSELFNLINKRLLRQKKMIISTNLSLEELLKTySERISSRLL 306
PRK08939 PRK08939
primosomal protein DnaI; Reviewed
 108-275 4.97e-11

primosomal protein DnaI; Reviewed


Pssm-ID: 236353 [Multi-domain]  Cd Length: 306  Bit Score: 62.58  E-value: 4.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 108 RRKKIARLMAASGITEEFEKLLFGNFITDGKPDMikDAYECAVEYYKDFQKikGERQNSIALLGQPGSGKTHLLTAIMNN 187
Cdd:PRK08939  104 EEKAIKKRIQSIYMPKDLLQASLADIDLDDRDRL--DALMAALDFLEAYPP--GEKVKGLYLYGDFGVGKSYLLAAIANE 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 188 LIKKK-SVHCMYFPyvEGMGDLKANF--DNLEAKLDAMRKVEVLFIDDLfkpinGQPRATDW-QVEQIQSVLNYRYLNHK 263
Cdd:PRK08939  180 LAKKGvSSTLLHFP--EFIRELKNSIsdGSVKEKIDAVKEAPVLMLDDI-----GAEQMSSWvRDEVLGVILQYRMQEEL 252

                         170
                  ....*....|..
gi 1125730593 264 PLLISSELTIDE 275
Cdd:PRK08939  253 PTFFTSNFDFDE 264
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 157-288 6.56e-10

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 56.77  E-value: 6.56e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 157 QKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK------SVHCMYFPYVEGMGDLKANFDNLEAKLdAMRKVEVLFI 230
Cdd:cd00009    12 EALELPPPKNLLLYGPPGTGKTTLARAIANELFRPGapflylNASDLLEGLVVAELFGHFLVRLLFELA-EKAKPGVLFI 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125730593 231 DDlfkpINGQPRATDWQVEQIQSVLNYRYLNHKPLLI----SSELTIDEILDIDEALGSRIH 288
Cdd:cd00009    91 DE----IDSLSRGAQNALLRVLETLNDLRIDRENVRVigatNRPLLGDLDRALYDRLDIRIV 148
PRK12377 PRK12377
putative replication protein; Provisional
 89-312 6.25e-07

putative replication protein; Provisional


Pssm-ID: 183482 [Multi-domain]  Cd Length: 248  Bit Score: 49.83  E-value: 6.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  89 TPDKASEWKDTYS-KQCECV----RRKKIARLMAASGITEEFEKLLFGNFITDGkpDMIKDAYECAVEYYKDFqkikGER 163
Cdd:PRK12377   27 TVDEWREWQLAEGrKRSEEInrqnQQLRVEKILNRSGIQPLHRKCSFANYQVQN--DGQRYALSQAKSIADEL----MTG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 164 QNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVHCMYFPYVegMGDLKANFDN---LEAKLDAMRKVEVLFIDDLfkpinG 239
Cdd:PRK12377  101 CTNFVFSGKPGTGKNHLAAAIGNRLLAKgRSVIVVTVPDV--MSRLHESYDNgqsGEKFLQELCKVDLLVLDEI-----G 173

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1125730593 240 QPRATDWQVEQIQSVLNYRYLNHKPLLISSELTIDEILDIdeaLGSRIHqmcrdyiviirgDRMQLNHrlGDW 312
Cdd:PRK12377  174 IQRETKNEQVVLNQIIDRRTASMRSVGMLTNLNHEAMSTL---LGERVM------------DRMTMNG--GRW 229
PRK07952 PRK07952
DNA replication protein DnaC; Validated
 108-313 6.30e-07

DNA replication protein DnaC; Validated


Pssm-ID: 181180 [Multi-domain]  Cd Length: 244  Bit Score: 49.77  E-value: 6.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 108 RRKKIARLMAASGITEEFEKLLFGNFITDGKPDMikDAYECAVEYYKDFqkikGERQNSIALLGQPGSGKTHLLTAIMNN 187
Cdd:PRK07952   49 RAMKMQRTFNRSGIRPLHQNCSFENYRVECEGQM--NALSKARQYVEEF----DGNIASFIFSGKPGTGKNHLAAAICNE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 188 LI-KKKSVHCMYFPYVegMGDLKANFDNLEAK----LDAMRKVEVLFIDDLfkpinGQPRATDWQVEQIQSVLNYRYLNH 262
Cdd:PRK07952  123 LLlRGKSVLIITVADI--MSAMKDTFSNSETSeeqlLNDLSNVDLLVIDEI-----GVQTESRYEKVIINQIVDRRSSSK 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1125730593 263 KPLLISSELTIDEILDIdeaLGSRIHqmcrdyiviirgDRMQLNHRLG---DWE 313
Cdd:PRK07952  196 RPTGMLTNSNMEEMTKL---LGERVM------------DRMRLGNSLWvifNWD 234
IstB_IS21 pfam01695
IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is ...
 162-309 1.67e-06

IstB-like ATP binding protein; This protein contains an ATP/GTP binding P-loop motif. It is found associated with IS21 family insertion sequences. The function of this protein is unknown, but it may perform a transposase function.


Pssm-ID: 426385 [Multi-domain]  Cd Length: 238  Bit Score: 48.21  E-value: 1.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 162 ERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVhcmYFPYVEGM-GDLKANFDN--LEAKLDAMRKVEVLFIDDL-FKP 236
Cdd:pfam01695  90 DRAQNVVLLGPPGVGKTHLAIALGVEACRAgYSV---RFTSAADLvNQLKRAHGDgkLTRKLQQLLKPDVLILDEWgYLP 166

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1125730593 237 INGQPRATDWQveqiqsVLNYRYlNHKPLLISSELTIDEILDI--DEALGS----RIHQMCrdYIVIIRGDRMQLNHRL 309
Cdd:pfam01695 167 LDQAEANLLFQ------VISKRY-EHRSIILTSNLPFGEWGQVfgDAVLATaildRLLHHC--HIVPIKGESYRLKTKS 236
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 163-287 1.21e-05

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 44.67  E-value: 1.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593  163 RQNSIALLGQPGSGKTHLLTAIMNNLIKKK-----------------SVHCMYFPYVEGMGDLKANFDNLEAKLDAmRKV 225
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGggviyidgedileevldQLLLIIVGGKKASGSGELRLRLALALARK-LKP 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125730593  226 EVLFIDDLFKPINGQPRATDWQVEQIQSVLNYRYLNHKPLLISSELTIDEILDIDEALGSRI 287
Cdd:smart00382  80 DVLILDEITSLLDAEQEALLLLLEELRLLLLLKSEKNLTVILTTNDEKDLGPALLRRRFDRR 141
DnaA COG0593
Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];
161-286 2.83e-05

Chromosomal replication initiation ATPase DnaA [Replication, recombination and repair];


Pssm-ID: 440358 [Multi-domain]  Cd Length: 303  Bit Score: 44.80  E-value: 2.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 161 GERQNSIALLGQPGSGKTHLLTAIMNNLIKK-KSVHCMYFPYVEGMGDLKA--NFDNLEAKLDAMRKVEVLFIDDL-Fkp 236
Cdd:COG0593    31 GKAYNPLFLYGGVGLGKTHLLHAIGNEALENnPGARVVYLTAEEFTNDFINaiRNNTIEEFKEKYRSVDVLLIDDIqF-- 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125730593 237 INGQPRatdWQVE--QIqsvLNYRYLNHKPLLISSELTIDEILDIDEALGSR 286
Cdd:COG0593   109 LAGKEA---TQEEffHT---FNALREAGKQIVLTSDRPPKELPGLEERLRSR 154
DnaA TIGR00362
chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; ...
 171-286 5.11e-04

chromosomal replication initiator protein DnaA; DnaA is involved in DNA biosynthesis; initiation of chromosome replication and can also be transcription regulator. The C-terminal of the family hits the pfam bacterial DnaA (bac_dnaA) domain family. For a review, see Kaguni (2006). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273037 [Multi-domain]  Cd Length: 437  Bit Score: 41.36  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 171 GQPGSGKTHLLTAIMNNLIKKKS------VHCMYF--PYVEGMgdLKANFDNLEAKLdamRKVEVLFIDDL-FkpINGQp 241
Cdd:TIGR00362 144 GGVGLGKTHLLHAIGNEILENNPnakvlyVSSEKFtnDFVNAL--RNNKMEEFKEKY---RSVDLLLIDDIqF--LAGK- 215

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1125730593 242 ratdwqvEQIQ----SVLNYRYLNHKPLLISSELTIDEILDIDEALGSR 286
Cdd:TIGR00362 216 -------ERTQeeffHTFNALHENNKQIVLTSDRPPKELPGLEDRLRSR 257
AAA_16 pfam13191
AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the ...
 156-298 5.60e-04

AAA ATPase domain; This family of domains contain a P-loop motif that is characteriztic of the AAA superfamily.


Pssm-ID: 433025 [Multi-domain]  Cd Length: 167  Bit Score: 39.79  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 156 FQKIKGERQNSIALLGQPGSGKTHLLTAIMNNLIKKK----SVHCMYFPYVEGMGDLKANFDNLEAKLDAMRKVEVL--- 228
Cdd:pfam13191  16 LDRVRSGRPPSVLLTGEAGTGKTTLLRELLRALERDGgyflRGKCDENLPYSPLLEALTREGLLRQLLDELESSLLEawr 95

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125730593 229 -FIDDLFKPINGQPRATDWQV-EQIQSVLNYRYLNHKPLLIsselTIDEILDIDEA----LGSRIHQMCRDYIVII 298
Cdd:pfam13191  96 aALLEALAPVPELPGDLAERLlDLLLRLLDLLARGERPLVL----VLDDLQWADEAslqlLAALLRLLESLPLLVV 167
AAA_5 pfam07728
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ...
 169-286 8.40e-04

AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400191 [Multi-domain]  Cd Length: 135  Bit Score: 38.81  E-value: 8.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 169 LLGQPGSGKThLLTAIMNNLIKKKSVHCMYFPyvEGMG--DLKA--NFDNLEAKL------DAMRKVEVLFIDDLFKPin 238
Cdd:pfam07728   4 LVGPPGTGKT-ELAERLAAALSNRPVFYVQLT--RDTTeeDLFGrrNIDPGGASWvdgplvRAAREGEIAVLDEINRA-- 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1125730593 239 gqprATDWQVEQIqSVLNYRYL------------NHKPLLISSELTIDEIL-DIDEALGSR 286
Cdd:pfam07728  79 ----NPDVLNSLL-SLLDERRLllpdggelvkaaPDGFRLIATMNPLDRGLnELSPALRSR 134
DnaA_homol_Hda TIGR03420
DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). ...
 160-270 3.31e-03

DnaA regulatory inactivator Hda; Members of this protein family are Hda (Homologous to DnaA). These proteins are about half the length of DnaA and homologous over length of Hda. In the model species Escherichia coli, the initiation of DNA replication requires DnaA bound to ATP rather than ADP; Hda helps facilitate the conversion of DnaA-ATP to DnaA-ADP. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 274571 [Multi-domain]  Cd Length: 226  Bit Score: 38.32  E-value: 3.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 160 KGERQNSIALLGQPGSGKTHLLTAIMNNLIKKKSvHCMYFPyvegMGDLKanfDNLEAKLDAMRKVEVLFIDDLFKpING 239
Cdd:TIGR03420  34 AGKGDRFLYLWGESGSGKSHLLQAACAAAEERGK-SAIYLP----LAELA---QADPEVLEGLEQADLVCLDDVEA-IAG 104

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1125730593 240 QPratDWQvEQIQSVLNYRYLNHKPLLISSE 270
Cdd:TIGR03420 105 QP---EWQ-EALFHLYNRVREAGGRLLIAGR 131
Bac_DnaA pfam00308
Bacterial dnaA protein;
161-286 3.74e-03

Bacterial dnaA protein;


Pssm-ID: 278724 [Multi-domain]  Cd Length: 219  Bit Score: 38.08  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 161 GERQNSIALLGQPGSGKTHLLTAIMNNLIKKKS------VHCMYF--PYVEGMGDLKAN-FDNleakldAMRKVEVLFID 231
Cdd:pfam00308  31 GKAYNPLFIYGGVGLGKTHLLHAIGNYALQNAPnlrvvyLTAEEFlnDFVDAIRDNKTNqFKE------KYRNVDVLLID 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 232 DL-FkpINGQpratdwqvEQIQS----VLNYRYLNHKPLLISSELTIDEILDIDEALGSR 286
Cdd:pfam00308 105 DIqF--LAGK--------EGTQEeffhTFNALHESGKQIVFSSDRPPKELEELEDRLRSR 154
dnaA PRK00149
chromosomal replication initiator protein DnaA;
165-286 4.34e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 234667 [Multi-domain]  Cd Length: 401  Bit Score: 38.58  E-value: 4.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 165 NSIALLGQPGSGKTHLLTAIMNNLIKKKS------VHCMYFpyvegMGDL-----KANFDNLEAKLdamRKVEVLFIDDL 233
Cdd:PRK00149  100 NPLFIYGGVGLGKTHLLHAIGNYILEKNPnakvvyVTSEKF-----TNDFvnalrNNTMEEFKEKY---RSVDVLLIDDI 171

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1125730593 234 -FkpINGQpratdwqvEQIQSVL----NYRYLNHKPLLISSELTIDEILDIDEALGSR 286
Cdd:PRK00149  172 qF--LAGK--------ERTQEEFfhtfNALHEAGKQIVLTSDRPPKELPGLEERLRSR 219
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
 167-309 5.50e-03

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 37.84  E-value: 5.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 167 IALLGQPGSGKTHLLTAIMNNLIKKKSVHCMYFPYVEGM----------------GDLKANFDNLEAKLDAM----RKVe 226
Cdd:COG3267    46 VVLTGEVGTGKTTLLRRLLERLPDDVKVAYIPNPQLSPAellraiadelglepkgASKADLLRQLQEFLLELaaagRRV- 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125730593 227 VLFIDDlfkpinGQ--PRATdwqVEQIQSVLNYRYLNHKPL---LI-SSELtiDEILDIDE--ALGSRIHQMC------- 291
Cdd:COG3267   125 VLIIDE------AQnlPPET---LEELRLLSNLETDSRKLLqivLVgQPEL--RERLARPElrQLRQRITARYhlrpldr 193

                         170       180
                  ....*....|....*....|.
gi 1125730593 292 ---RDYIviirgdrmqlNHRL 309
Cdd:COG3267   194 eetAAYI----------EHRL 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH