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Conserved domains on  [gi|1125431683|gb|OLD60685|]
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hypothetical protein AUF60_00120 [Gemmatimonadetes bacterium 13_1_20CM_69_28]

Protein Classification

3-hydroxyacyl-CoA dehydrogenase family protein( domain architecture ID 11441205)

3-hydroxyacyl-CoA dehydrogenase (HCDH) family protein such as mitochondrial HCDH, which plays an essential role in the beta-oxidation of short chain fatty acids

CATH:  3.40.50.720|1.10.1040.10
EC:  1.1.1.-
Gene Ontology:  GO:0003857|GO:0006635|GO:0070403
PubMed:  3479790
SCOP:  4000107

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 23-262 2.87e-65

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


:

Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 207.27  E-value: 2.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERgLLELHQGRSLLQTVQD 102
Cdd:COG1250     3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADA-ALARITPTTDLAALAD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:COG1250    82 ADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVLkKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGpaLGWaAAGPHLTYHLAAGD 262
Cdd:COG1250   162 TVATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLG--FGF-PMGPFELADLVGLD 237
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 23-262 2.87e-65

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 207.27  E-value: 2.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERgLLELHQGRSLLQTVQD 102
Cdd:COG1250     3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADA-ALARITPTTDLAALAD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:COG1250    82 ADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVLkKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGpaLGWaAAGPHLTYHLAAGD 262
Cdd:COG1250   162 TVATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLG--FGF-PMGPFELADLVGLD 237
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 22-327 3.36e-57

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 187.56  E-value: 3.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  22 PRKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHQGRSLLQTVQ 101
Cdd:PRK06129    2 MGSVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLADAVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 102 DADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAV 181
Cdd:PRK06129   82 DADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 182 ASVTRAQEYLRALGRMPIVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGPHLTYHLAAg 261
Cdd:PRK06129  162 ATLARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNA- 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125431683 262 DGGVTAFLQQLLASFEgwwgqlatwqRLEPEQQR------ALTQGVERAYKGKV--EELREA---RDRRLSAILRAL 327
Cdd:PRK06129  241 PGGVADYAQRYGPMYR----------RMAAERGQpvpwdgELVARVEAERRAALplDQLAARqawRDRRLMALAAHR 307
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 24-202 3.36e-54

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 175.42  E-value: 3.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  24 KVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERgLLELHQGRSLLQTVQDA 103
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDA-ALARISFTTDLAAAVDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 104 DWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVAS 183
Cdd:pfam02737  80 DLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPET 159

                         170
                  ....*....|....*....
gi 1125431683 184 VTRAQEYLRALGRMPIVLK 202
Cdd:pfam02737 160 VATTVELAKKIGKTPVVVK 178
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 23-237 1.38e-13

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 71.41  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPR------RARALVALghategmvERGLLELHQGRSL 96
Cdd:TIGR02441 336 KTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKglnkkvKRKKITSL--------ERDSILSNLTPTL 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  97 -LQTVQDADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVP 175
Cdd:TIGR02441 408 dYSGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIIT 487

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125431683 176 GARTAVASVTRAQEYLRALGRMPIVLKKpVPGYVVGRIAAAVWRECIDLvLTDVIAVDDLDR 237
Cdd:TIGR02441 488 HDGTSKDTLASAVAVGLKQGKVVIVVKD-GPGFYTTRCLGPMLAEVIRL-LQEGVDPKKLDK 547
 
Name Accession Description Interval E-value
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 23-262 2.87e-65

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 207.27  E-value: 2.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERgLLELHQGRSLLQTVQD 102
Cdd:COG1250     3 KKVAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEEEADA-ALARITPTTDLAALAD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:COG1250    82 ADLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVLkKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGpaLGWaAAGPHLTYHLAAGD 262
Cdd:COG1250   162 TVATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLG--FGF-PMGPFELADLVGLD 237
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 22-327 3.36e-57

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 187.56  E-value: 3.36e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  22 PRKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHQGRSLLQTVQ 101
Cdd:PRK06129    2 MGSVAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGEAPDAVLARIRVTDSLADAVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 102 DADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAV 181
Cdd:PRK06129   82 DADYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAP 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 182 ASVTRAQEYLRALGRMPIVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGPHLTYHLAAg 261
Cdd:PRK06129  162 ATLARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNA- 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125431683 262 DGGVTAFLQQLLASFEgwwgqlatwqRLEPEQQR------ALTQGVERAYKGKV--EELREA---RDRRLSAILRAL 327
Cdd:PRK06129  241 PGGVADYAQRYGPMYR----------RMAAERGQpvpwdgELVARVEAERRAALplDQLAARqawRDRRLMALAAHR 307
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 24-202 3.36e-54

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 175.42  E-value: 3.36e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  24 KVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERgLLELHQGRSLLQTVQDA 103
Cdd:pfam02737   1 KVAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEEEVDA-ALARISFTTDLAAAVDA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 104 DWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVAS 183
Cdd:pfam02737  80 DLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPET 159

                         170
                  ....*....|....*....
gi 1125431683 184 VTRAQEYLRALGRMPIVLK 202
Cdd:pfam02737 160 VATTVELAKKIGKTPVVVK 178
PRK07531 PRK07531
carnitine 3-dehydrogenase;
19-327 1.26e-50

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 175.31  E-value: 1.26e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  19 IALPRKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGmERAAIDVPRRA-RALVALGHATegMVERGLLELHQgrSLL 97
Cdd:PRK07531    1 MTMIMKAACIGGGVIGGGWAARFLLAGIDVAVFDPHPEA-ERIIGEVLANAeRAYAMLTDAP--LPPEGRLTFCA--SLA 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  98 QTVQDADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGA 177
Cdd:PRK07531   76 EAVAGADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGG 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 178 RTAVASVTRAQEYLRALGRMPIVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGPHLTYH 257
Cdd:PRK07531  156 KTSPETIRRAKEILREIGMKPVHIAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRWAQMGLFETYR 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1125431683 258 LAAGDGGVTAFLQQLLASFEGWWGQLATwqrlEPEQQRALT-----QGVERAYKGKVEELREARDRRLSAILRAL 327
Cdd:PRK07531  236 IAGGEAGMRHFLAQFGPCLKWPWTKLMD----VPDLDDALVdkiagQSDAQSGGLSIRELERIRDENLVGIMQAL 306
PRK07066 PRK07066
L-carnitine dehydrogenase;
23-331 7.99e-48

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 163.47  E-value: 7.99e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERglleLHQGRSLLQTVQD 102
Cdd:PRK07066    8 KTFAAIGSGVIGSGWVARALAHGLDVVAWDPAPGAEAALRANVANAWPALERQGLAPGASPAR----LRFVATIEACVAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK07066   84 ADFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAPE 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGPHLTYHLAAGD 262
Cdd:PRK07066  164 AVDAAMGIYRALGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTLAGGD 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1125431683 263 GGVTAFLQQLLASFEGWWGQLATWQRLEPEQQRALTQGVERAYKGKVEELREARDRRLSAILRALEQAR 331
Cdd:PRK07066  244 AGMRHFMQQFGPALELPWTKLVAPELTDALIDRVVEGTAEQQGPRSIKALERYRDECITEVLEAIAAVK 312
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 23-252 2.78e-44

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 153.77  E-value: 2.78e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMverGLLELHQGrsLLQTVQD 102
Cdd:PRK06130    5 QNLAIIGAGTMGSGIAALFARKGLQVVLIDVMEGALERARGVIERALGVYAPLGIASAGM---GRIRMEAG--LAAAVSG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK06130   80 ADLVIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSPQ 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGP 252
Cdd:PRK06130  160 TVATTMALLRSIGKRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALTGP 229
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
24-242 3.07e-38

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 137.61  E-value: 3.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  24 KVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHQGRSLLQTVQDA 103
Cdd:PRK09260    3 KLVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQLESAQQEIASIFEQGVARGKLTEAARQAALARLSYSLDLKAAVADA 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 104 DWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVAS 183
Cdd:PRK09260   83 DLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETSDET 162

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1125431683 184 VTRAQEYLRALGRMPIVLKKpVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLG 242
Cdd:PRK09260  163 VQVAKEVAEQMGKETVVVNE-FPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIRLG 220
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 23-242 1.44e-34

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 127.92  E-value: 1.44e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHQGRSLlQTVQD 102
Cdd:PLN02545    5 KKVGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARLVKKGKMSQEEADATLGRIRCTTNL-EELRD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PLN02545   84 ADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVEIIRGADTSDE 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVlKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLG 242
Cdd:PLN02545  164 VFDATKALAERFGKTVVC-SQDYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLG 222
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 23-242 4.10e-30

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 115.83  E-value: 4.10e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHqGRSLLQTVQD 102
Cdd:PRK05808    4 QKIGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATITKSLDRLVKKGKMTEADKEAALARIT-GTTDLDDLKD 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK05808   83 ADLVIEAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATSDA 162

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1125431683 183 SVTRAQEYLRALGRMPIVLKKpVPGYVVGRIAAAVWRECIdLVLTDVIA-VDDLDRAVSLG 242
Cdd:PRK05808  163 THEAVEALAKKIGKTPVEVKN-APGFVVNRILIPMINEAI-FVLAEGVAtAEDIDEGMKLG 221
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 23-242 7.93e-29

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 112.41  E-value: 7.93e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELhQGRSLLQTVQD 102
Cdd:PRK07530    5 KKVGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATINGNLARQVAKGKISEEARAAALARI-STATDLEDLAD 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK07530   84 CDLVIEAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATDEA 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 183 SVTRAQEYLRALGRMPIVlKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLG 242
Cdd:PRK07530  164 TFEAAKEFVTKLGKTITV-AEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMKLG 222
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 23-238 1.36e-26

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 109.55  E-value: 1.36e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHATEGMVERGLLELHQGRSLlQTVQD 102
Cdd:PRK08268    8 ATVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLAKLVEKGKLTAEQADAALARLRPVEAL-ADLAD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK08268   87 CDLVVEAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPERVAGLHFFNPVPLMKLVEVVSGLATDPA 166

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125431683 183 SVTRAQEYLRALGRMPiVLKKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRA 238
Cdd:PRK08268  167 VADALYALARAWGKTP-VRAKDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAI 221
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 33-251 2.80e-26

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 105.91  E-value: 2.80e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  33 IGCGWAALCAAAGWPVTLFDASSRGMErAAIDVPRRARA--------LVALGHATEGMVER--GLLELHQGRSLLQTVQD 102
Cdd:PRK08269    1 MGQGIALAFAFAGHDVTLIDFKPRDAA-GWRALDAEARAeiertlaaLVALGRIDAAQADAvlARIAVVARDGAADALAD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 103 ADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAVA 182
Cdd:PRK08269   80 ADLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPA 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1125431683 183 SVTRAQEYLRALGRMPIVLkKPVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAG 251
Cdd:PRK08269  160 VVDRLAALLERIGKVPVVC-GPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFAVLG 227
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 23-259 4.78e-25

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 102.26  E-value: 4.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERA--AI-DVPRRARALVALGHATEGMVERGLLELHQGRSLlQT 99
Cdd:PRK06035    4 KVIGVVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNAmeLIeSGPYGLRNLVEKGKMSEDEAKAIMARIRTSTSY-ES 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 100 VQDADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGART 179
Cdd:PRK06035   83 LSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALT 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 180 AVASVTRAQEYLRALGRMPIVLKKpVPGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSL------GPALGWAAAGPH 253
Cdd:PRK06035  163 SEETFNTTVELSKKIGKIPIEVAD-VPGFFTTRFIEGWLLEAIRSFEIGIATIKDIDEMCKLafgfpmGPFELMDIIGID 241


                  ....*.
gi 1125431683 254 LTYHLA 259
Cdd:PRK06035  242 TVYHIA 247
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
23-243 3.94e-24

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 99.63  E-value: 3.94e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPRRARALVALGHAT-EGMVERGLLELHQGRSLLQTVQ 101
Cdd:PRK08293    4 KNVTVAGAGVLGSQIAFQTAFHGFDVTIYDISDEALEKAKERIAKLADRYVRDLEATkEAPAEAALNRITLTTDLAEAVK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683 102 DADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPGARTAV 181
Cdd:PRK08293   84 DADLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFAEATGRPEKFLALHFANEIWKNNTAEIMGHPGTDP 163

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1125431683 182 ASVTRAQEYLRALGRMPIVLKKPVPGYV-----VGRIAAAvwrecIDLVLTDVIAVDDLDRA------VSLGP 243
Cdd:PRK08293  164 EVFDTVVAFAKAIGMVPIVLKKEQPGYIlnsllVPFLSAA-----LALWAKGVADPETIDKTwmiatgAPMGP 231
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 23-244 4.51e-19

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 85.81  E-value: 4.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAaidvprRARALVALGHATE-GMVERGLLELHQGR----SLL 97
Cdd:PRK07819    6 QRVGVVGAGQMGAGIAEVCARAGVDVLVFETTEELATAG------RNRIEKSLERAVSrGKLTERERDAALARlrftTDL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  98 QTVQDADWVIEAIHEELGAKQKLFHAIEEVAG-PETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVPG 176
Cdd:PRK07819   80 GDFADRQLVIEAVVEDEAVKTEIFAELDKVVTdPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPT 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1125431683 177 ARTAVASVTRAQEYLRAlgrmpiVLKKPV------PGYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPA 244
Cdd:PRK07819  160 LVTSEATVARAEEFASD------VLGKQVvraqdrSGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCA 227
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
23-238 5.67e-16

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 78.78  E-value: 5.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAA-AGWPVTLFDASSRGMERA------AIDVPRRARALVALghategmvER-GLLELHQGR 94
Cdd:PRK11154  310 NKVGVLGGGLMGGGIAYVTATkAGLPVRIKDINPQGINHAlkyswdLLDKKVKRRHLKPS--------ERdKQMALISGT 381

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  95 SLLQTVQDADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELV 174
Cdd:PRK11154  382 TDYRGFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEVI 461

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1125431683 175 PGARTAVASVTRAQEYLRALGRMPIVLKKPvPGYVVGRIAAAVWRECIDLVLTDViAVDDLDRA 238
Cdd:PRK11154  462 PHAKTSAETIATTVALAKKQGKTPIVVRDG-AGFYVNRILAPYINEAARLLLEGE-PIEHIDAA 523
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
22-213 1.08e-13

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 71.82  E-value: 1.08e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  22 PRKVAVIGAGDIGCGWAALCAAAGWPVTLFD----ASSRGMERAAidvprrarALVAlghateGMVERGLLELHQGRSLL 97
Cdd:PRK11730  313 VKQAAVLGAGIMGGGIAYQSASKGVPVIMKDinqkALDLGMTEAA--------KLLN------KQVERGKIDGAKMAGVL 378

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  98 QTVQ---------DADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLI 168
Cdd:PRK11730  379 SSIRptldyagfeRVDVVVEAVVENPKVKAAVLAEVEQKVREDTILASNTSTISISLLAKALKRPENFCGMHFFNPVHRM 458

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1125431683 169 PLVELVPGARTAVASVTRAQEYLRALGRMPIVLKKpVPGYVVGRI 213
Cdd:PRK11730  459 PLVEVIRGEKTSDETIATVVAYASKMGKTPIVVND-CPGFFVNRV 502
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 23-237 1.38e-13

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 71.41  E-value: 1.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  23 RKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMERAAIDVPR------RARALVALghategmvERGLLELHQGRSL 96
Cdd:TIGR02441 336 KTLAVLGAGLMGAGIAQVSVDKGLKTVLKDATPAGLDRGQQQVFKglnkkvKRKKITSL--------ERDSILSNLTPTL 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  97 -LQTVQDADWVIEAIHEELGAKQKLFHAIEEVAGPETLVTSSSSGIPPTELFSRCRRQDRCLVAHPLNPPQLIPLVELVP 175
Cdd:TIGR02441 408 dYSGFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIIT 487

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125431683 176 GARTAVASVTRAQEYLRALGRMPIVLKKpVPGYVVGRIAAAVWRECIDLvLTDVIAVDDLDR 237
Cdd:TIGR02441 488 HDGTSKDTLASAVAVGLKQGKVVIVVKD-GPGFYTTRCLGPMLAEVIRL-LQEGVDPKKLDK 547
PRK07251 PRK07251
FAD-containing oxidoreductase;
18-113 3.00e-05

FAD-containing oxidoreductase;


Pssm-ID: 180907 [Multi-domain]  Cd Length: 438  Bit Score: 45.51  E-value: 3.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431683  18 LIALPRKVAVIGAGDIGCGWAALCAAAGWPVTLFDASSRGMeraaidvPRRARALVALghATEGMVERGlLELHQGRSLL 97
Cdd:PRK07251  153 LETLPERLGIIGGGNIGLEFAGLYNKLGSKVTVLDAASTIL-------PREEPSVAAL--AKQYMEEDG-ITFLLNAHTT 222

                          90
                  ....*....|....*.
gi 1125431683  98 QTVQDADWVIEAIHEE 113
Cdd:PRK07251  223 EVKNDGDQVLVVTEDE 238
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 207-258 2.42e-04

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 39.51  E-value: 2.42e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125431683 207 GYVVGRIAAAVWRECIDLVLTDVIAVDDLDRAVSLGPALGWAAAGPHLTYHL 258
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGL 52
ApbA pfam02558
Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also ...
 25-63 1.64e-03

Ketopantoate reductase PanE/ApbA; This is a family of 2-dehydropantoate 2-reductases also known as ketopantoate reductases, EC:1.1.1.169. The reaction catalyzed by this enzyme is: (R)-pantoate + NADP(+) <=> 2-dehydropantoate + NADPH. AbpA catalyzes the NADPH reduction of ketopantoic acid to pantoic acid in the alternative pyrimidine biosynthetic (APB) pathway. ApbA and PanE are allelic. ApbA, the ketopantoate reductase enzyme is required for the synthesis of thiamine via the APB biosynthetic pathway.


Pssm-ID: 426831 [Multi-domain]  Cd Length: 147  Bit Score: 38.37  E-value: 1.64e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1125431683  25 VAVIGAGDIGCGWAALCAAAGWPVTLFDassRGMERAAI 63
Cdd:pfam02558   1 IAILGAGAIGSLLGARLAKAGHDVTLIL---RGAELAAI 36
PRK06522 PRK06522
2-dehydropantoate 2-reductase; Reviewed
 24-52 3.81e-03

2-dehydropantoate 2-reductase; Reviewed


Pssm-ID: 235821 [Multi-domain]  Cd Length: 304  Bit Score: 38.68  E-value: 3.81e-03
                          10        20
                  ....*....|....*....|....*....
gi 1125431683  24 KVAVIGAGDIGCGWAALCAAAGWPVTLFD 52
Cdd:PRK06522    2 KIAILGAGAIGGLFGAALAQAGHDVTLVA 30
PanE COG1893
Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of ...
 24-52 5.16e-03

Ketopantoate reductase [Coenzyme transport and metabolism]; Ketopantoate reductase is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 441497 [Multi-domain]  Cd Length: 305  Bit Score: 38.30  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|....*....
gi 1125431683  24 KVAVIGAGDIGCGWAALCAAAGWPVTLFD 52
Cdd:COG1893     2 KIAILGAGAIGGLLGARLARAGHDVTLVA 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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