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Conserved domains on  [gi|1125431539|gb|OLD60564|]
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hypothetical protein AUF60_00675 [Gemmatimonadetes bacterium 13_1_20CM_69_28]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10789277)

class I SAM-dependent methyltransferase is an enzyme that uses S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyl transfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047
PubMed:  12826405
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 4-126 4.81e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


:

Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.78  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   4 RRSLRALDLAAVRRALVVGAGDDPYRRRLPHAQTYV--------RVDLVRRPGRTD------VVADAAALPFADASFECV 69
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVtgvdispeMLELARERAAEAglnvefVVGDAEDLPFPDGSFDLV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1125431539  70 VATEVLEYLPEPAKFASESRRVLADRGLAVITvpfvfhdhhDYWRPTRRALTELFRD 126
Cdd:COG2226    92 ISSFVLHHLPDPERALAEIARVLKPGGRLVVV---------DFSPPDLAELEELLAE 139
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 4-126 4.81e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.78  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   4 RRSLRALDLAAVRRALVVGAGDDPYRRRLPHAQTYV--------RVDLVRRPGRTD------VVADAAALPFADASFECV 69
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVtgvdispeMLELARERAAEAglnvefVVGDAEDLPFPDGSFDLV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1125431539  70 VATEVLEYLPEPAKFASESRRVLADRGLAVITvpfvfhdhhDYWRPTRRALTELFRD 126
Cdd:COG2226    92 ISSFVLHHLPDPERALAEIARVLKPGGRLVVV---------DFSPPDLAELEELLAE 139
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 19-100 5.38e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.22  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  19 LVVGAGDDPYRRRLP-HAQTYVRVDL-----------VRRPGRTDVVADAAALPFADASFECVVATEVLEYLPEPAKFAS 86
Cdd:pfam08241   1 LDVGCGTGLLTELLArLGARVTGVDIspemlelarekAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALR 80

                          90
                  ....*....|....
gi 1125431539  87 ESRRVLADRGLAVI 100
Cdd:pfam08241  81 EIARVLKPGGILII 94
PRK08317 PRK08317
hypothetical protein; Provisional
 52-156 1.52e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 55.33  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  52 VVADAAALPFADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVITVP----FVFHDHHDywRPTRRALTELFRDY 127
Cdd:PRK08317   74 VRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTdwdtLVWHSGDR--ALMRKILNFWSDHF 151

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1125431539 128 SSVRVsaqGNRLHTMFD---LVTTAFSPVPVL 156
Cdd:PRK08317  152 ADPWL---GRRLPGLFReagLTDIEVEPYTLI 180
 
Name Accession Description Interval E-value
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 4-126 4.81e-12

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 60.78  E-value: 4.81e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   4 RRSLRALDLAAVRRALVVGAGDDPYRRRLPHAQTYV--------RVDLVRRPGRTD------VVADAAALPFADASFECV 69
Cdd:COG2226    12 EALLAALGLRPGARVLDLGCGTGRLALALAERGARVtgvdispeMLELARERAAEAglnvefVVGDAEDLPFPDGSFDLV 91

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1125431539  70 VATEVLEYLPEPAKFASESRRVLADRGLAVITvpfvfhdhhDYWRPTRRALTELFRD 126
Cdd:COG2226    92 ISSFVLHHLPDPERALAEIARVLKPGGRLVVV---------DFSPPDLAELEELLAE 139
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 19-100 5.38e-12

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 59.22  E-value: 5.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  19 LVVGAGDDPYRRRLP-HAQTYVRVDL-----------VRRPGRTDVVADAAALPFADASFECVVATEVLEYLPEPAKFAS 86
Cdd:pfam08241   1 LDVGCGTGLLTELLArLGARVTGVDIspemlelarekAPREGLTFVVGDAEDLPFPDNSFDLVLSSEVLHHVEDPERALR 80

                          90
                  ....*....|....
gi 1125431539  87 ESRRVLADRGLAVI 100
Cdd:pfam08241  81 EIARVLKPGGILII 94
COG4627 COG4627
Predicted SAM-depedendent methyltransferase [General function prediction only];
19-144 7.79e-12

Predicted SAM-depedendent methyltransferase [General function prediction only];


Pssm-ID: 443666 [Multi-domain]  Cd Length: 161  Bit Score: 60.65  E-value: 7.79e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  19 LVVGAGDDPYRRrlphaqtYVRVDLVRRPGrTDVVADAA-ALPFADASFECVVATEVLE--YLPEPAKFASESRRVLADR 95
Cdd:COG4627     7 LNIGCGPKRLPG-------WLNVDIVPAPG-VDIVGDLTdPLPFPDNSVDAIYSSHVLEhlDYEEAPLALKECYRVLKPG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1125431539  96 GLAVITVPFVFHDHHDYWRPTRRALT---------ELFRDYSSVRVSAQGNRLHTMFD 144
Cdd:COG4627    79 GILRIVVPDLEHVARLYLAEYDAALDvaelrlagpIDPLGIILGERLAGLAARHSVLF 136
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 2-103 2.60e-10

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 55.79  E-value: 2.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   2 LIRRSLRALDLA----------AVRRALVVGAgdDPYRRRLPHAQTY---VRVDLVrrpgrtdvVADAAALPFADASFEC 68
Cdd:COG2227    21 LLPAGGRVLDVGcgtgrlalalARRGADVTGV--DISPEALEIARERaaeLNVDFV--------QGDLEDLPLEDGSFDL 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1125431539  69 VVATEVLEYLPEPAKFASESRRVLADRGLAVITVP 103
Cdd:COG2227    91 VICSEVLEHLPDPAALLRELARLLKPGGLLLLSTP 125
PRK08317 PRK08317
hypothetical protein; Provisional
 52-156 1.52e-09

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 55.33  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  52 VVADAAALPFADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVITVP----FVFHDHHDywRPTRRALTELFRDY 127
Cdd:PRK08317   74 VRGDADGLPFPDGSFDAVRSDRVLQHLEDPARALAEIARVLRPGGRVVVLDTdwdtLVWHSGDR--ALMRKILNFWSDHF 151

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1125431539 128 SSVRVsaqGNRLHTMFD---LVTTAFSPVPVL 156
Cdd:PRK08317  152 ADPWL---GRRLPGLFReagLTDIEVEPYTLI 180
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
2-123 2.11e-07

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 48.84  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   2 LIRRSLRALDLAAVRRALVVGAGDDPYRRRL-PHAQTYVRVDL--------VRRPGRTDV-VADAAALPFADASFECVVA 71
Cdd:COG4976    34 LAEELLARLPPGPFGRVLDLGCGTGLLGEALrPRGYRLTGVDLseemlakaREKGVYDRLlVADLADLAEPDGRFDLIVA 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125431539  72 TEVLEYLPEPAKFASESRRVLADRGLAVITVPfVFHDHHDYWRPTRRALTEL 123
Cdd:COG4976   114 ADVLTYLGDLAAVFAGVARALKPGGLFIFSVE-DADGSGRYAHSLDYVRDLL 164
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 52-96 3.29e-07

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 46.40  E-value: 3.29e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1125431539  52 VVADAAALPFADASFECVVATEVLEYLPEP--AKFASESRRVLADRG 96
Cdd:pfam13649  50 VQGDAEDLPFPDGSFDLVVSSGVLHHLPDPdlEAALREIARVLKPGG 96
PLN02244 PLN02244
tocopherol O-methyltransferase
 53-101 5.67e-05

tocopherol O-methyltransferase


Pssm-ID: 215135 [Multi-domain]  Cd Length: 340  Bit Score: 42.81  E-value: 5.67e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1125431539  53 VADAAALPFADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVIT 101
Cdd:PLN02244  174 VADALNQPFEDGQFDLVWSMESGEHMPDKRKFVQELARVAAPGGRIIIV 222
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 38-127 8.79e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 41.26  E-value: 8.79e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539  38 YVRVDLVRRPGRTDVVADAAALPFADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVITVPFVFHDHHD------ 111
Cdd:pfam13489  53 SPIAIERALLNVRFDQFDEQEAAVPAGKFDVIVAREVLEHVPDPPALLRQIAALLKPGGLLLLSTPLASDEADRlllewp 132

                          90       100
                  ....*....|....*....|....
gi 1125431539 112 YWRP--------TRRALTELFRDY 127
Cdd:pfam13489 133 YLRPrnghislfSARSLKRLLEEA 156
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 1-100 1.01e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 38.60  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125431539   1 MLIRRSLRALDLAA---------VRRAL----VVGAgdDPY-------RRRLPHAQTYVRVDLVrrpgrtdvVADAAALP 60
Cdd:PRK00216   47 LGVRPGDKVLDLACgtgdlaialAKAVGktgeVVGL--DFSegmlavgREKLRDLGLSGNVEFV--------QGDAEALP 116

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1125431539  61 FADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVI 100
Cdd:PRK00216  117 FPDNSFDAVTIAFGLRNVPDIDKALREMYRVLKPGGRLVI 156
PLN02490 PLN02490
MPBQ/MSBQ methyltransferase
 55-126 5.22e-03

MPBQ/MSBQ methyltransferase


Pssm-ID: 215270 [Multi-domain]  Cd Length: 340  Bit Score: 36.79  E-value: 5.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1125431539  55 DAAALPFADASFECVVATEVLEYLPEPAKFASESRRVLADRGLAVITVPFvfhdHHDYWrptrraLTELFRD 126
Cdd:PLN02490  168 DAEDLPFPTDYADRYVSAGSIEYWPDPQRGIKEAYRVLKIGGKACLIGPV----HPTFW------LSRFFAD 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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