NCBI Conserved Domain Search

NCBI

3D Macromolecular Structures

Conserved Domains

Conserved domains on [gi|1125384461|gb|OLD21516|]

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hypothetical protein AUJ01_02035 [Acidobacteria bacterium 13_1_40CM_3_65_5]

Protein Classification

CRTAC1 family protein( domain architecture ID 10608401)

CRTAC1 family protein similar to human cartilage acidic protein 1 (CRTAC1), an extracellular matrix protein of articular cartilage and is a marker for cultured chondrocytes

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

UnbV_ASPIC

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...

438-503

1.07e-19

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.

:

Pssm-ID: 429555 Cd Length: 66 Bit Score: 83.02 E-value: 1.07e-19

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 438 GARVTVSVAGRRLIDEVRSGGSFCSQNDLRIHVGLGARSRADRIEVAWPSGAADTIAGVDADQLVV 503
Cdd:pfam07593   1 GARVTVTTAGGRQYREVTGGRGYLSSSDPRLHFGLGDATTIDSLEVRWPDGKVQTLENVAANQTLT 66

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

65-139

3.99e-11

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

:

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 58.39 E-value: 3.99e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1125384461  65 DYDNDGWPDIFLVNGARLenspsddapisHLYRNKGDGTFSDVTRRSGlssSSPRWNTGCAFLDFNRDGRLDLFV 139
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-----------RLYLNNGDGTFTFITSVSL---GGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

213-279

1.08e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

:

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 54.15 E-value: 1.08e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125384461 213 DYDNDRWPDVYVANDSSASLlFHNDGHGTFKEVGLPAGvaltadGRAQAGMGVSAGDYNRDGWLDIV 279
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRL-YLNNGDGTFTFITSVSL------GGGGGGLSVAVGDLDGDGRLDLL 60

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

269-334

8.66e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

:

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 46.06 E-value: 8.66e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 269 DYNRDGWLDIVKTNfdDDTTSLYRNLGGGTFDDATVAgglAVNTRYLGWGTGFVDFDLDTWPDIFI 334
Cdd:pfam13517   1 DLDGDGKLDLVVAN--DGGLRLYLNNGDGTFTFITSV---SLGGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

128-224

1.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

:

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 39.52 E-value: 1.81e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 128 DFNRDGRLDLFVsayvahadatryppgsrsncswkglgvmcgphgLDGSHNALFRGNEDGTFTDVSEAAGlrkPRPAYGF 207
Cdd:pfam13517   1 DLDGDGKLDLVV---------------------------------ANDGGLRLYLNNGDGTFTFITSVSL---GGGGGGL 44

                          90
                  ....*....|....*..
gi 1125384461 208 TPLVLDYDNDRWPDVYV 224
Cdd:pfam13517  45 SVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

323-402

3.68e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

:

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 36.05 E-value: 3.68e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 323 DFDLDTWPDIFIVNghvypeadriggdhsyEQPKLLYRNLGNGRFEDVSMLAGPGLLarkASRGAAFGDLFNTGQQDIVV 402
Cdd:pfam13517   1 DLDGDGKLDLVVAN----------------DGGLRLYLNNGDGTFTFITSVSLGGGG---GGLSVAVGDLDGDGRLDLLV 61

Name

Accession

Description

Interval

E-value

UnbV_ASPIC

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...

438-503

1.07e-19

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.

Pssm-ID: 429555 Cd Length: 66 Bit Score: 83.02 E-value: 1.07e-19

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 438 GARVTVSVAGRRLIDEVRSGGSFCSQNDLRIHVGLGARSRADRIEVAWPSGAADTIAGVDADQLVV 503
Cdd:pfam07593   1 GARVTVTTAGGRQYREVTGGRGYLSSSDPRLHFGLGDATTIDSLEVRWPDGKVQTLENVAANQTLT 66

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

65-139

3.99e-11

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 58.39 E-value: 3.99e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1125384461  65 DYDNDGWPDIFLVNGARLenspsddapisHLYRNKGDGTFSDVTRRSGlssSSPRWNTGCAFLDFNRDGRLDLFV 139
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-----------RLYLNNGDGTFTFITSVSL---GGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

213-279

1.08e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 54.15 E-value: 1.08e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125384461 213 DYDNDRWPDVYVANDSSASLlFHNDGHGTFKEVGLPAGvaltadGRAQAGMGVSAGDYNRDGWLDIV 279
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRL-YLNNGDGTFTFITSVSL------GGGGGGLSVAVGDLDGDGRLDLL 60

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

269-334

8.66e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 46.06 E-value: 8.66e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 269 DYNRDGWLDIVKTNfdDDTTSLYRNLGGGTFDDATVAgglAVNTRYLGWGTGFVDFDLDTWPDIFI 334
Cdd:pfam13517   1 DLDGDGKLDLVVAN--DGGLRLYLNNGDGTFTFITSV---SLGGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

128-224

1.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 39.52 E-value: 1.81e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 128 DFNRDGRLDLFVsayvahadatryppgsrsncswkglgvmcgphgLDGSHNALFRGNEDGTFTDVSEAAGlrkPRPAYGF 207
Cdd:pfam13517   1 DLDGDGKLDLVV---------------------------------ANDGGLRLYLNNGDGTFTFITSVSL---GGGGGGL 44

                          90
                  ....*....|....*..
gi 1125384461 208 TPLVLDYDNDRWPDVYV 224
Cdd:pfam13517  45 SVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

323-402

3.68e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 36.05 E-value: 3.68e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 323 DFDLDTWPDIFIVNghvypeadriggdhsyEQPKLLYRNLGNGRFEDVSMLAGPGLLarkASRGAAFGDLFNTGQQDIVV 402
Cdd:pfam13517   1 DLDGDGKLDLVVAN----------------DGGLRLYLNNGDGTFTFITSVSLGGGG---GGLSVAVGDLDGDGRLDLLV 61

Name

Accession

Description

Interval

E-value

UnbV_ASPIC

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several ...

438-503

1.07e-19

ASPIC and UnbV; This conserved sequence is found associated with pfam00515 in several paralogous proteins in Rhodopirellula baltica. It is also found associated with pfam01839 in several eukaryotic integrin-like proteins (e.g. human ASPIC) and in several other bacterial proteins.

Pssm-ID: 429555 Cd Length: 66 Bit Score: 83.02 E-value: 1.07e-19

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 438 GARVTVSVAGRRLIDEVRSGGSFCSQNDLRIHVGLGARSRADRIEVAWPSGAADTIAGVDADQLVV 503
Cdd:pfam07593   1 GARVTVTTAGGRQYREVTGGRGYLSSSDPRLHFGLGDATTIDSLEVRWPDGKVQTLENVAANQTLT 66

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

65-139

3.99e-11

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 58.39 E-value: 3.99e-11

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1125384461  65 DYDNDGWPDIFLVNGARLenspsddapisHLYRNKGDGTFSDVTRRSGlssSSPRWNTGCAFLDFNRDGRLDLFV 139
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGL-----------RLYLNNGDGTFTFITSVSL---GGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

213-279

1.08e-09

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 54.15 E-value: 1.08e-09

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1125384461 213 DYDNDRWPDVYVANDSSASLlFHNDGHGTFKEVGLPAGvaltadGRAQAGMGVSAGDYNRDGWLDIV 279
Cdd:pfam13517   1 DLDGDGKLDLVVANDGGLRL-YLNNGDGTFTFITSVSL------GGGGGGLSVAVGDLDGDGRLDLL 60

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

269-334

8.66e-07

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 46.06 E-value: 8.66e-07

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1125384461 269 DYNRDGWLDIVKTNfdDDTTSLYRNLGGGTFDDATVAgglAVNTRYLGWGTGFVDFDLDTWPDIFI 334
Cdd:pfam13517   1 DLDGDGKLDLVVAN--DGGLRLYLNNGDGTFTFITSV---SLGGGGGGLSVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

128-224

1.81e-04

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 39.52 E-value: 1.81e-04

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 128 DFNRDGRLDLFVsayvahadatryppgsrsncswkglgvmcgphgLDGSHNALFRGNEDGTFTDVSEAAGlrkPRPAYGF 207
Cdd:pfam13517   1 DLDGDGKLDLVV---------------------------------ANDGGLRLYLNNGDGTFTFITSVSL---GGGGGGL 44

                          90
                  ....*....|....*..
gi 1125384461 208 TPLVLDYDNDRWPDVYV 224
Cdd:pfam13517  45 SVAVGDLDGDGRLDLLV 61

FG-GAP_3

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related ...

323-402

3.68e-03

FG-GAP-like repeat; This entry represents a repeat found in alpha integrins and related proteins in which form a 7-fold repeat that adopts a beta-propeller fold. This repeat contains a putative calcium-binding site. These repeats are found in multiple proteins from eukaryotes and bacteria and mediate diverse biological processes at both molecular and cellular levels, such as cell-cell interactions, host-pathogen recognition or innate immune responses.

Pssm-ID: 433275 [Multi-domain] Cd Length: 61 Bit Score: 36.05 E-value: 3.68e-03

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125384461 323 DFDLDTWPDIFIVNghvypeadriggdhsyEQPKLLYRNLGNGRFEDVSMLAGPGLLarkASRGAAFGDLFNTGQQDIVV 402
Cdd:pfam13517   1 DLDGDGKLDLVVAN----------------DGGLRLYLNNGDGTFTFITSVSLGGGG---GGLSVAVGDLDGDGRLDLLV 61

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01

References:

Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.

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of the residues that compose this conserved feature have been mapped to the query sequence.

Click on the triangle to view details about the feature, including a multiple sequence alignment of your query sequence and the protein sequences used to curate the domain model, where hash marks (#) above the aligned sequences show the location of the conserved feature residues.

The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions. Click on the triangle for interactive 3D structure viewing options.

Functional characterization of the conserved domain architecture found on the query. Click here to see more details.

This image shows a graphical summary of conserved domains identified on the query sequence. The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits (labeled illustration) or all hits (labeled illustration).
Domains are color coded according to superfamilies to which they have been assigned. Hits with scores that pass a domain-specific threshold (specific hits) are drawn in bright colors. Others (non-specific hits) and superfamily placeholders are drawn in pastel colors.
if a domain or superfamily has been annotated with functional sites (conserved features), they are mapped to the query sequence and indicated through sets of triangles with the same color and shade of the domain or superfamily that provides the annotation.
Mouse over the colored bars or triangles to see descriptions of the domains and features. click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.

The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores. Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.

To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page, or click on the triangles, if present, that represent functional sites (conserved features) mapped to the query sequence.

Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence. (labeled illustration)
Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence. (labeled illustration)
Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance. (labeled illustration)
Four types of hits can be shown, as available, for each region on the query sequence:

specific hits meet or exceed a domain-specific e-value threshold (illustrated example) and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains

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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool (CDART).

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