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Conserved domains on  [gi|1125371884|gb|OLD09815|]
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hypothetical protein AUI95_00020 [Crenarchaeota archaeon 13_1_40CM_3_52_4]

Protein Classification

cyclic nucleotide-binding domain-containing protein( domain architecture ID 10034975)

cyclic nucleotide-binding domain-containing protein binds cyclic nucleotides (cAMP or cGMP) where binding of the effector leads to conformational changes; may be involved in regulating transcription, be present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK), or be part of vertebrate cyclic nucleotide-gated ion-channels.

CATH:  2.60.120.10
Gene Ontology:  GO:0030552|GO:0030551
PubMed:  6280140|12087135|17601606|11734894
SCOP:  4000272

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 18-129 9.71e-22

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


:

Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 83.91  E-value: 9.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  18 LFAGLKGKQIKSVASAfARERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQP 92
Cdd:cd00038     1 LFSGLDDEELEELADA-LEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKldedgREQIVGFLGPGDLFGELALLGNGP 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1125371884  93 RSATVVsAESGTKCLVMPAWNFTAAIETDPKVAMGVM 129
Cdd:cd00038    80 RSATVR-ALTDSELLVLPRSDFRRLLQEYPELARRLL 115
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 18-129 9.71e-22

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 83.91  E-value: 9.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  18 LFAGLKGKQIKSVASAfARERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQP 92
Cdd:cd00038     1 LFSGLDDEELEELADA-LEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKldedgREQIVGFLGPGDLFGELALLGNGP 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1125371884  93 RSATVVsAESGTKCLVMPAWNFTAAIETDPKVAMGVM 129
Cdd:cd00038    80 RSATVR-ALTDSELLVLPRSDFRRLLQEYPELARRLL 115
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 19-145 1.80e-21

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 85.42  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  19 FAGLKGKQIKSVASAFaRERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQPR 93
Cdd:COG0664     1 FAGLSDEELEALLAHL-ELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRisedgREQILGFLGPGDFFGELSLLGGEPS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125371884  94 SATVVsAESGTKCLVMPAWNFTAAIETDPKVAMGVMKELARRLRETTNALTE 145
Cdd:COG0664    80 PATAE-ALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVS 130
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 37-121 3.62e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 71.10  E-value: 3.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  37 ERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQPRSATVVsAESGTKCLVMPA 111
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRtledgREQILAVLGPGDFFGELALLGGEPRSATVV-ALTDSELLVIPR 79

                          90
                  ....*....|
gi 1125371884 112 WNFTAAIETD 121
Cdd:pfam00027  80 EDFLELLERD 89
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 18-132 3.36e-14

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 64.34  E-value: 3.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884   18 LFAGLKGKQIKSVASAFaRERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQP 92
Cdd:smart00100   1 LFKNLDAEELRELADAL-EPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKvledgEEQIVGTLGPGDFFGELALLTNSR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1125371884   93 RSATV-VSAESGTKCLVMPAWNFTAAIETDPKVAMGVMKEL 132
Cdd:smart00100  80 RAASAaAVALELATLLRIDFRDFLQLLPELPQLLLELLLEL 120
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
38-140 3.08e-10

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 55.76  E-value: 3.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  38 RSYNAGEVIEKEGGSAVAFYLITGGSVEVRKGEK-----LVTKLGRGQFFGEMALIDK-QPRSATVVSAesgTKCLV--M 109
Cdd:PRK11753   23 HKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEegkemILSYLNQGDFIGELGLFEEgQERSAWVRAK---TACEVaeI 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1125371884 110 PAWNFTAAIETDPKVAMGVMKELARRLRETT 140
Cdd:PRK11753  100 SYKKFRQLIQVNPDILMALSAQMARRLQNTS 130
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 42-136 3.43e-06

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 44.89  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  42 AGEVIEKEGGSAVAFYLITGGSVEVRKGE----KLVTKLGRGQFFGEMALIDKQPRSATVVSAESGTKCLVMPAWNFTAA 117
Cdd:TIGR03896 168 AGTILIHEGGTVDALYILLYGEASLSISPdgpgREVGSSRRGEILGETPFLNGSLPGTATVKAIENSVLLAIDKQQLAAK 247

                          90
                  ....*....|....*....
gi 1125371884 118 IETDPKVAMGVMKELARRL 136
Cdd:TIGR03896 248 LQQDVGFASRFYRVIASLL 266
 
Name Accession Description Interval E-value
CAP_ED cd00038
effector domain of the CAP family of transcription factors; members include CAP (or cAMP ...
 18-129 9.71e-22

effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO sensor. In all cases binding of the effector leads to conformational changes and the ability to activate transcription. Cyclic nucleotide-binding domain similar to CAP are also present in cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) and vertebrate cyclic nucleotide-gated ion-channels. Cyclic nucleotide-monophosphate binding domain; proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues; the best studied is the prokaryotic catabolite gene activator, CAP, where such a domain is known to be composed of three alpha-helices and a distinctive eight-stranded, antiparallel beta-barrel structure; three conserved glycine residues are thought to be essential for maintenance of the structural integrity of the beta-barrel; CooA is a homodimeric transcription factor that belongs to CAP family; cAMP- and cGMP-dependent protein kinases (cAPK and cGPK) contain two tandem copies of the cyclic nucleotide-binding domain; cAPK's are composed of two different subunits, a catalytic chain and a regulatory chain, which contains both copies of the domain; cGPK's are single chain enzymes that include the two copies of the domain in their N-terminal section; also found in vertebrate cyclic nucleotide-gated ion-channels


Pssm-ID: 237999 [Multi-domain]  Cd Length: 115  Bit Score: 83.91  E-value: 9.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  18 LFAGLKGKQIKSVASAfARERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQP 92
Cdd:cd00038     1 LFSGLDDEELEELADA-LEERRFPAGEVIIRQGDPADSLYIVLSGSVEVYKldedgREQIVGFLGPGDLFGELALLGNGP 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1125371884  93 RSATVVsAESGTKCLVMPAWNFTAAIETDPKVAMGVM 129
Cdd:cd00038    80 RSATVR-ALTDSELLVLPRSDFRRLLQEYPELARRLL 115
Crp COG0664
cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal ...
 19-145 1.80e-21

cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms];


Pssm-ID: 440428 [Multi-domain]  Cd Length: 207  Bit Score: 85.42  E-value: 1.80e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  19 FAGLKGKQIKSVASAFaRERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQPR 93
Cdd:COG0664     1 FAGLSDEELEALLAHL-ELRTLKKGEVLFREGDPADHLYFVLSGLVKLYRisedgREQILGFLGPGDFFGELSLLGGEPS 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125371884  94 SATVVsAESGTKCLVMPAWNFTAAIETDPKVAMGVMKELARRLRETTNALTE 145
Cdd:COG0664    80 PATAE-ALEDSELLRIPREDLEELLERNPELARALLRLLARRLRQLQERLVS 130
cNMP_binding pfam00027
Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, ...
 37-121 3.62e-17

Cyclic nucleotide-binding domain; This domain sensor domain can bind cAMP, cGMP, c-di-GMP, oxygen and 2-oxoglutarate (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 459637 [Multi-domain]  Cd Length: 89  Bit Score: 71.10  E-value: 3.62e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  37 ERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQPRSATVVsAESGTKCLVMPA 111
Cdd:pfam00027   1 LRSYKAGEVIFREGDPADSLYIVLSGKVKVYRtledgREQILAVLGPGDFFGELALLGGEPRSATVV-ALTDSELLVIPR 79

                          90
                  ....*....|
gi 1125371884 112 WNFTAAIETD 121
Cdd:pfam00027  80 EDFLELLERD 89
cNMP smart00100
Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a ...
 18-132 3.36e-14

Cyclic nucleotide-monophosphate binding domain; Catabolite gene activator protein (CAP) is a prokaryotic homologue of eukaryotic cNMP-binding domains, present in ion channels, and cNMP-dependent kinases.


Pssm-ID: 197516 [Multi-domain]  Cd Length: 120  Bit Score: 64.34  E-value: 3.36e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884   18 LFAGLKGKQIKSVASAFaRERSYNAGEVIEKEGGSAVAFYLITGGSVEVRK-----GEKLVTKLGRGQFFGEMALIDKQP 92
Cdd:smart00100   1 LFKNLDAEELRELADAL-EPVRYPAGEVIIRQGDVGDSFYIIVSGEVEVYKvledgEEQIVGTLGPGDFFGELALLTNSR 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1125371884   93 RSATV-VSAESGTKCLVMPAWNFTAAIETDPKVAMGVMKEL 132
Cdd:smart00100  80 RAASAaAVALELATLLRIDFRDFLQLLPELPQLLLELLLEL 120
PRK11753 PRK11753
cAMP-activated global transcriptional regulator CRP;
38-140 3.08e-10

cAMP-activated global transcriptional regulator CRP;


Pssm-ID: 236969 [Multi-domain]  Cd Length: 211  Bit Score: 55.76  E-value: 3.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  38 RSYNAGEVIEKEGGSAVAFYLITGGSVEVRKGEK-----LVTKLGRGQFFGEMALIDK-QPRSATVVSAesgTKCLV--M 109
Cdd:PRK11753   23 HKYPAKSTLIHAGEKAETLYYIVKGSVAVLIKDEegkemILSYLNQGDFIGELGLFEEgQERSAWVRAK---TACEVaeI 99

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1125371884 110 PAWNFTAAIETDPKVAMGVMKELARRLRETT 140
Cdd:PRK11753  100 SYKKFRQLIQVNPDILMALSAQMARRLQNTS 130
PLN02868 PLN02868
acyl-CoA thioesterase family protein
 4-110 8.05e-07

acyl-CoA thioesterase family protein


Pssm-ID: 178459 [Multi-domain]  Cd Length: 413  Bit Score: 47.02  E-value: 8.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884   4 KDNPQVVKMLAGVPLFAGLKGKQIKSVASAfARERSYNAGEVIEKEGGSAVAFYLITGGSVEV-RKGEKLVTK---LGRG 79
Cdd:PLN02868    1 MNTESVVEFLGSVPLLQRLPSSSLKKIAEV-VVPKRYGKGEYVVREGEPGDGLYFIWKGEAEVsGPAEEESRPeflLKRY 79

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1125371884  80 QFFGEMalIDKQPRSATVVsAESGTKCLVMP 110
Cdd:PLN02868   80 DYFGYG--LSGSVHSADVV-AVSELTCLVLP 107
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 42-136 3.43e-06

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 44.89  E-value: 3.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  42 AGEVIEKEGGSAVAFYLITGGSVEVRKGE----KLVTKLGRGQFFGEMALIDKQPRSATVVSAESGTKCLVMPAWNFTAA 117
Cdd:TIGR03896 168 AGTILIHEGGTVDALYILLYGEASLSISPdgpgREVGSSRRGEILGETPFLNGSLPGTATVKAIENSVLLAIDKQQLAAK 247

                          90
                  ....*....|....*....
gi 1125371884 118 IETDPKVAMGVMKELARRL 136
Cdd:TIGR03896 248 LQQDVGFASRFYRVIASLL 266
cyc_nuc_ocin TIGR03896
bacteriocin-type transport-associated protein; Members of this protein family are ...
 31-136 5.09e-04

bacteriocin-type transport-associated protein; Members of this protein family are uncharacterized and contain two copies of the cyclic nucleotide-binding domain pfam00027. Members are restricted to select cyanobacteria but are found regularly in association with a transport operon that, in turn, is associated with the production of putative bacteriocins. The models describing the transport operon are TIGR03794, TIGR03796, and TIGR03797.


Pssm-ID: 274839 [Multi-domain]  Cd Length: 317  Bit Score: 38.72  E-value: 5.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  31 ASAFARERSYNAGEVIEKEGGSAVAFYLITGGSVEVR----KGEKL-----VTKLGRGQFFGEMALIDKQPRSATVVsAE 101
Cdd:TIGR03896   4 MVAIGHQREIAAGTTLIEEGKAADFLFILLDGTFTVTtpqpEDNPLtrafeLARLSRGEIVGEMSLLETRPPVATIK-AV 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1125371884 102 SGTKCLVMPAWNFTAAIETDPKVAMGVMKELARRL 136
Cdd:TIGR03896  83 PKSRVMSIPVGELAAKLQSDVGFAAHFYRAIAIKL 117
PRK10402 PRK10402
DNA-binding transcriptional activator YeiL; Provisional
 31-123 3.34e-03

DNA-binding transcriptional activator YeiL; Provisional


Pssm-ID: 236682 [Multi-domain]  Cd Length: 226  Bit Score: 36.24  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125371884  31 ASAFARERSYNAGEVIEKEGGS-AVAFYLITGGSvevrkgeKLVTKLGRGQ-----------FFGEMALIDKQ--PRSat 96
Cdd:PRK10402   27 VSADTELFHFLAREYIVQEGQQpSYLFYLTRGRA-------KLYATLANGKvslidffaapcFIGEIELIDKDheTKA-- 97

                          90       100
                  ....*....|....*....|....*..
gi 1125371884  97 vVSAESGTKCLVMPAWNFTAAIETDPK 123
Cdd:PRK10402   98 -VQAIEECWCLALPMKDCRPLLLNDAL 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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