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Conserved domains on  [gi|1125209119|gb|OLB60397|]
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6-phosphofructokinase, partial [Gemmatimonadetes bacterium 13_2_20CM_2_69_23]

Protein Classification

6-phosphofructokinase( domain architecture ID 1910159)

6-phosphofructokinase catalyzes the conversion of fructose-6-phosphate to fructose-1, 6-diphosphate and is a key regulatory enzyme of glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PFKA_PPi_Ttgales super family cl49212
diphosphate--fructose-6-phosphate 1-phosphotransferase;
4-378 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


The actual alignment was detected with superfamily member NF041103:

Pssm-ID: 469029  Cd Length: 406  Bit Score: 595.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTEHVVELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:NF041103    1 LAILVGGGPAPGINSVISAVTIEAINHGWEVLGIYDGFKHLAKGDTSKVIPLTIDDVSRIHFRGGSILGTSRANPTKSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPG-LGLAHVPKTIDNDLPLPSDIDTFGFSTACNLGKDLVRNLMQ 162
Cdd:NF041103   81 DLENVVDTLKELGVTHLVTIGGDDTAFSASKVAKYAGGrIRVVHVPKTIDNDLPLPEGIPTFGFETARHVGVELVKNLME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 163 DAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAILSEGLAEK 242
Cdd:NF041103  161 DARTTNRWYFVVAMGRKAGHLALGIGKAAGATLTIIPEEFREEKITLQTVVDILVGSIIKRLAMGRNYGVAVLAEGLIEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 243 L---DLESLGPVERDQYGNVRLAELDLGRVLKDRVAGRLRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRSLGYWATRF 319
Cdd:NF041103  241 IdpeDLEALGGVERDEHGHIRLAEINFGEILKKAVKKRLKELGIKITIVDKNIGYELRCADPIPFDIEYTRDLGYGAVRF 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1125209119 320 LLEGGSNAMVTIQAGRLVPMPFGLLLDPKTGKIRVRYVDVESEMYQTLWAYMIRLKPED 378
Cdd:NF041103  321 LLEGGTGAMISIQNGRFVPIPFEDMLDPKTGRTRVRMVDVESESYRIARRYMIRLEKED 379
 
Name Accession Description Interval E-value
PFKA_PPi_Ttgales NF041103
diphosphate--fructose-6-phosphate 1-phosphotransferase;
4-378 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 469029  Cd Length: 406  Bit Score: 595.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTEHVVELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:NF041103    1 LAILVGGGPAPGINSVISAVTIEAINHGWEVLGIYDGFKHLAKGDTSKVIPLTIDDVSRIHFRGGSILGTSRANPTKSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPG-LGLAHVPKTIDNDLPLPSDIDTFGFSTACNLGKDLVRNLMQ 162
Cdd:NF041103   81 DLENVVDTLKELGVTHLVTIGGDDTAFSASKVAKYAGGrIRVVHVPKTIDNDLPLPEGIPTFGFETARHVGVELVKNLME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 163 DAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAILSEGLAEK 242
Cdd:NF041103  161 DARTTNRWYFVVAMGRKAGHLALGIGKAAGATLTIIPEEFREEKITLQTVVDILVGSIIKRLAMGRNYGVAVLAEGLIEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 243 L---DLESLGPVERDQYGNVRLAELDLGRVLKDRVAGRLRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRSLGYWATRF 319
Cdd:NF041103  241 IdpeDLEALGGVERDEHGHIRLAEINFGEILKKAVKKRLKELGIKITIVDKNIGYELRCADPIPFDIEYTRDLGYGAVRF 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1125209119 320 LLEGGSNAMVTIQAGRLVPMPFGLLLDPKTGKIRVRYVDVESEMYQTLWAYMIRLKPED 378
Cdd:NF041103  321 LLEGGTGAMISIQNGRFVPIPFEDMLDPKTGRTRVRMVDVESESYRIARRYMIRLEKED 379
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 1-366 1.74e-99

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 298.53  E-value: 1.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPAR 80
Cdd:COG0205     1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 TPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALpGLGLAHVPKTIDNDLPLpsdID-TFGFSTACNLGKDLVRN 159
Cdd:COG0205    78 TEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEY-GIPVVGIPKTIDNDLPG---TDyTIGFDTAVNTAAEAIDR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 160 LMQDAATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADilegAIIKRRMHGRDHG 231
Cdd:COG0205   154 LRDTAASHERVFVVEVMGRHAGW------------LALAaglaggADLILipEVPFDLDKLLE----KLKERRKRGKGYS 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 232 VAILSEGLAEKlDLESLGPVERDQYGNVRLAelDLGRVLKDRVAGRLrERKVDVTIvgkdLGYELRCAAPGAHDIQYSRS 311
Cdd:COG0205   218 IIVVAEGAGDE-DGEAVLEADTDAFGHVRLG--GIGEYLAKEIEERT-GIETRVTV----LGHLQRGGSPSAFDRVLASR 289

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMPFGLLLDpktgkiRVRYVDVESEMYQT 366
Cdd:COG0205   290 LGAAAVELLLEGKTGVMVGIRRGEIVLVPLEEVAN------KEKPVDPDSPLIQL 338
PFK pfam00365
Phosphofructokinase;
4-238 3.39e-58

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 190.24  E-value: 3.39e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTEhvvELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDID---ELTWRDVSGILNRGGTILGTSRSKPFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALpGLGLAHVPKTIDNDLPLpSDIdTFGFSTACNLGKDLVRNLMQD 163
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER-GIPVVGIPKTIDNDIPG-TDY-TIGFDTALNTIVEAIDRIRDT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 164 AATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADilegaIIKRRMHGRDHGVAIL 235
Cdd:pfam00365 156 ASSHNRVFVVEVMGRHCGW------------LALMaglaggADAILipEIPFDIEELCE-----KIKELRKGKRFSIIVV 218


                  ...
gi 1125209119 236 SEG 238
Cdd:pfam00365 219 AEG 221
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
1-363 9.97e-55

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 182.59  E-value: 9.97e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGGSIIRTSRTNPAR 80
Cdd:PRK03202    1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDI---VKLDLKSVSDIINRGGTILGSARFPEFK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 TPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKAlpGLGLAHVPKTIDNDLPLpSDIdTFGFSTACNLGKDLVRNL 160
Cdd:PRK03202   78 DEEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEH--GIPVIGLPGTIDNDIAG-TDY-TIGFDTALNTAVEAIDRL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 161 MQDAATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADILEgaiiKRRMHGRDHGV 232
Cdd:PRK03202  154 RDTASSHERVFIVEVMGRHAGD------------LALHagiaggAEVILipEVPFDIEELCAKIK----KGRERGKKHAI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 233 AILSEGlaekldlesLGPVErdqygnvrlaelDLGRVLKDRVAGRLRerkvdVTIvgkdLGYELRCAAPGAHD-IQYSRs 311
Cdd:PRK03202  218 IVVAEG---------VMPAE------------ELAKEIEERTGLETR-----VTV----LGHIQRGGSPTAFDrVLASR- 266

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMPFGLLLDPKTGKIRVRYVDVESEM 363
Cdd:PRK03202  267 MGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 5-334 1.41e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 177.88  E-value: 1.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPARTPEG 84
Cdd:cd00363     4 GVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD---IKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  85 VGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL----AHVPKTIDNDLPlPSDIdTFGFSTACNLGKDLVRNL 160
Cdd:cd00363    81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQgfnvIGLPGTIDNDIK-GTDY-TIGFDTALKTIVEAIDRI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 161 MQDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKItVDRLADILEgaiiKRRMHGRDHGVAILSEGLA 240
Cdd:cd00363   159 RDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW-EEEMVDVIK----KRRERGKRHGIVIVAEGAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 241 EKLdleslgpverdqygNVRLAELDLGRVLKDRVAGRLRerkvdVTIvgkdLGYELRCAAPGAHDIQYSRSLGYWATRFL 320
Cdd:cd00363   234 DFI--------------PKPITEKLLAKLVEERLGFDTR-----ATV----LGHVQRGGTPTAFDRILASRLGAEAVELL 290

                         330
                  ....*....|....
gi 1125209119 321 LEGGSNAMVTIQAG 334
Cdd:cd00363   291 LEGTGGTPVGIQNL 304
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 4-341 2.53e-44

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 155.54  E-value: 2.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEA-RNHGVRVLGCYDGFKWLVEGDTehVVELTINDLSRIHFDGGSIIRTSRTNPARTP 82
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAiAEYGWEVIGIRDGWRGLLEGDT--VPLLDLEDVRGILPRGGTILGSSRTNPFKYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  83 E-GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKAlpGLGLAHVPKTIDNDLpLPSDIdTFGFSTACNLGKDLVRNLM 161
Cdd:TIGR02483  80 EdGDDKIVANLKELGLDALIAIGGDGTLGIARRLADK--GLPVVGVPKTIDNDL-EATDY-TFGFDTAVEIATEALDRLH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 162 QDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEflesKITVDRLADilegAIIKRRMHGRDHGVAILSEGLAE 241
Cdd:TIGR02483 156 TTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEI----PFDIDSVCE----KVRERFARGKRFAIVVVAEGAKP 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 242 KLDLESLGPVERDQYGNVRLAelDLGRVLKDRVAGRLrERKVDVTIvgkdLGYELRCAAPGAHDIQYSRSLGYWATRFLL 321
Cdd:TIGR02483 228 KGGEMVVQEGVKDAFGHVRLG--GIGNWLAEEIERRT-GIETRATV----LGHLQRGGSPSAFDRVLATRFGVAAVDLVH 300

                         330       340
                  ....*....|....*....|
gi 1125209119 322 EGGSNAMVTIQAGRLVPMPF 341
Cdd:TIGR02483 301 EGQFGHMVALRGTDIVYVPI 320
 
Name Accession Description Interval E-value
PFKA_PPi_Ttgales NF041103
diphosphate--fructose-6-phosphate 1-phosphotransferase;
4-378 0e+00

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 469029  Cd Length: 406  Bit Score: 595.69  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTEHVVELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:NF041103    1 LAILVGGGPAPGINSVISAVTIEAINHGWEVLGIYDGFKHLAKGDTSKVIPLTIDDVSRIHFRGGSILGTSRANPTKSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPG-LGLAHVPKTIDNDLPLPSDIDTFGFSTACNLGKDLVRNLMQ 162
Cdd:NF041103   81 DLENVVDTLKELGVTHLVTIGGDDTAFSASKVAKYAGGrIRVVHVPKTIDNDLPLPEGIPTFGFETARHVGVELVKNLME 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 163 DAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAILSEGLAEK 242
Cdd:NF041103  161 DARTTNRWYFVVAMGRKAGHLALGIGKAAGATLTIIPEEFREEKITLQTVVDILVGSIIKRLAMGRNYGVAVLAEGLIEK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 243 L---DLESLGPVERDQYGNVRLAELDLGRVLKDRVAGRLRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRSLGYWATRF 319
Cdd:NF041103  241 IdpeDLEALGGVERDEHGHIRLAEINFGEILKKAVKKRLKELGIKITIVDKNIGYELRCADPIPFDIEYTRDLGYGAVRF 320

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1125209119 320 LLEGGSNAMVTIQAGRLVPMPFGLLLDPKTGKIRVRYVDVESEMYQTLWAYMIRLKPED 378
Cdd:NF041103  321 LLEGGTGAMISIQNGRFVPIPFEDMLDPKTGRTRVRMVDVESESYRIARRYMIRLEKED 379
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 1-366 1.74e-99

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 298.53  E-value: 1.74e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPAR 80
Cdd:COG0205     1 MKRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGD---IIDLTREDVSGILQRGGTILGSSRSKPFK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 TPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALpGLGLAHVPKTIDNDLPLpsdID-TFGFSTACNLGKDLVRN 159
Cdd:COG0205    78 TEEGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEY-GIPVVGIPKTIDNDLPG---TDyTIGFDTAVNTAAEAIDR 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 160 LMQDAATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADilegAIIKRRMHGRDHG 231
Cdd:COG0205   154 LRDTAASHERVFVVEVMGRHAGW------------LALAaglaggADLILipEVPFDLDKLLE----KLKERRKRGKGYS 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 232 VAILSEGLAEKlDLESLGPVERDQYGNVRLAelDLGRVLKDRVAGRLrERKVDVTIvgkdLGYELRCAAPGAHDIQYSRS 311
Cdd:COG0205   218 IIVVAEGAGDE-DGEAVLEADTDAFGHVRLG--GIGEYLAKEIEERT-GIETRVTV----LGHLQRGGSPSAFDRVLASR 289

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMPFGLLLDpktgkiRVRYVDVESEMYQT 366
Cdd:COG0205   290 LGAAAVELLLEGKTGVMVGIRRGEIVLVPLEEVAN------KEKPVDPDSPLIQL 338
PFK pfam00365
Phosphofructokinase;
4-238 3.39e-58

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 190.24  E-value: 3.39e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTEhvvELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDID---ELTWRDVSGILNRGGTILGTSRSKPFKTEE 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALpGLGLAHVPKTIDNDLPLpSDIdTFGFSTACNLGKDLVRNLMQD 163
Cdd:pfam00365  79 GREKIAENLKKLGIDALVVIGGDGSLTGANKLSEER-GIPVVGIPKTIDNDIPG-TDY-TIGFDTALNTIVEAIDRIRDT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 164 AATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADilegaIIKRRMHGRDHGVAIL 235
Cdd:pfam00365 156 ASSHNRVFVVEVMGRHCGW------------LALMaglaggADAILipEIPFDIEELCE-----KIKELRKGKRFSIIVV 218


                  ...
gi 1125209119 236 SEG 238
Cdd:pfam00365 219 AEG 221
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
1-363 9.97e-55

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 182.59  E-value: 9.97e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGGSIIRTSRTNPAR 80
Cdd:PRK03202    1 MKRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDI---VKLDLKSVSDIINRGGTILGSARFPEFK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 TPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKAlpGLGLAHVPKTIDNDLPLpSDIdTFGFSTACNLGKDLVRNL 160
Cdd:PRK03202   78 DEEGRAKAIENLKKLGIDALVVIGGDGSYMGAKRLTEH--GIPVIGLPGTIDNDIAG-TDY-TIGFDTALNTAVEAIDRL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 161 MQDAATTERWFFVTVMGRRAGHlalgiggaagatLTVV------AEEFL--ESKITVDRLADILEgaiiKRRMHGRDHGV 232
Cdd:PRK03202  154 RDTASSHERVFIVEVMGRHAGD------------LALHagiaggAEVILipEVPFDIEELCAKIK----KGRERGKKHAI 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 233 AILSEGlaekldlesLGPVErdqygnvrlaelDLGRVLKDRVAGRLRerkvdVTIvgkdLGYELRCAAPGAHD-IQYSRs 311
Cdd:PRK03202  218 IVVAEG---------VMPAE------------ELAKEIEERTGLETR-----VTV----LGHIQRGGSPTAFDrVLASR- 266

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMPFGLLLDPKTGKIRVRYVDVESEM 363
Cdd:PRK03202  267 MGAHAVELLLEGKGGRMVGIQNNKIVHVPIEEAVENMKHPFDKDLYELAKKL 318
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 5-334 1.41e-52

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 177.88  E-value: 1.41e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPARTPEG 84
Cdd:cd00363     4 GVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGD---IKELDWESVSDIINRGGTIIGSARCKEFRTEEG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  85 VGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL----AHVPKTIDNDLPlPSDIdTFGFSTACNLGKDLVRNL 160
Cdd:cd00363    81 RAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPSKYQgfnvIGLPGTIDNDIK-GTDY-TIGFDTALKTIVEAIDRI 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 161 MQDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKItVDRLADILEgaiiKRRMHGRDHGVAILSEGLA 240
Cdd:cd00363   159 RDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW-EEEMVDVIK----KRRERGKRHGIVIVAEGAI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 241 EKLdleslgpverdqygNVRLAELDLGRVLKDRVAGRLRerkvdVTIvgkdLGYELRCAAPGAHDIQYSRSLGYWATRFL 320
Cdd:cd00363   234 DFI--------------PKPITEKLLAKLVEERLGFDTR-----ATV----LGHVQRGGTPTAFDRILASRLGAEAVELL 290

                         330
                  ....*....|....
gi 1125209119 321 LEGGSNAMVTIQAG 334
Cdd:cd00363   291 LEGTGGTPVGIQNL 304
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 5-370 1.33e-45

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 164.32  E-value: 1.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAA--ATIEARNHGVRVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGG-SIIRTSRTNpART 81
Cdd:PRK07085   74 GVILSGGQAPGGHNVIAGlfDGLKKLNPDSKLFGFIGGPLGLLNGKY---IEITEEVIDEYRNTGGfDMIGSGRTK-IET 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  82 PEGVGRVAETLKRHGVDYLITIGGDD----TAFAASRVAKALPGLGLAHVPKTIDNDLPlPSDIDT-FGFSTACNLGKDL 156
Cdd:PRK07085  150 EEQKEACLETVKKLKLDGLVIIGGDDsntnAAILAEYFAKHGCKTQVIGVPKTIDGDLK-NEFIETsFGFDTATKTYSEM 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 157 VRNLMQDAATTER-WFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAIL 235
Cdd:PRK07085  229 IGNISRDALSAKKyWHFIKLMGRSASHIALECALQTHPNICLISEEVAEKKMSLQDIVHYIASVIADRAAKGKNYGVILI 308

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 236 SEGLAE-------------------------------------KLDLESLG-----P--------VERDQYGNVRLAELD 265
Cdd:PRK07085  309 PEGLIEfipemkslikelnsllaenesefkgldteaqreyiisKLSPESAKlfkslPediarqllLDRDPHGNVQVSKIE 388

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 266 LGRVLKDRVAGRLRERKVDVTIVGK------DLGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNAMVTIQ------- 332
Cdd:PRK07085  389 TEKLLIEMVKKELEKLKPEGKYKGPfsaishFFGYEGRSAFPSNFDADYCYALGYTAALLILNGKTGYMSTIKnltspyt 468

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 1125209119 333 --AGRLVPMPFGLLLDPKTGK----IRVRYVDVESEMYQTLWAY 370
Cdd:PRK07085  469 ewIAGAVPLTMMMNMERRHGKekpvIKKALVDLDGPPFKYFAKY 512
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 4-341 2.53e-44

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 155.54  E-value: 2.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEA-RNHGVRVLGCYDGFKWLVEGDTehVVELTINDLSRIHFDGGSIIRTSRTNPARTP 82
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAiAEYGWEVIGIRDGWRGLLEGDT--VPLLDLEDVRGILPRGGTILGSSRTNPFKYE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  83 E-GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKAlpGLGLAHVPKTIDNDLpLPSDIdTFGFSTACNLGKDLVRNLM 161
Cdd:TIGR02483  80 EdGDDKIVANLKELGLDALIAIGGDGTLGIARRLADK--GLPVVGVPKTIDNDL-EATDY-TFGFDTAVEIATEALDRLH 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 162 QDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEflesKITVDRLADilegAIIKRRMHGRDHGVAILSEGLAE 241
Cdd:TIGR02483 156 TTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEI----PFDIDSVCE----KVRERFARGKRFAIVVVAEGAKP 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 242 KLDLESLGPVERDQYGNVRLAelDLGRVLKDRVAGRLrERKVDVTIvgkdLGYELRCAAPGAHDIQYSRSLGYWATRFLL 321
Cdd:TIGR02483 228 KGGEMVVQEGVKDAFGHVRLG--GIGNWLAEEIERRT-GIETRATV----LGHLQRGGSPSAFDRVLATRFGVAAVDLVH 300

                         330       340
                  ....*....|....*....|
gi 1125209119 322 EGGSNAMVTIQAGRLVPMPF 341
Cdd:TIGR02483 301 EGQFGHMVALRGTDIVYVPI 320
Pyrophosphate_PFK cd00765
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 4-331 8.39e-38

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include pyrophosphate-dependent phosphofructokinases. These are found in bacteria as well as plants. These may be dimeric nonallosteric enzymes as in bacteria or allosteric heterotetramers as in plants.


Pssm-ID: 238390  Cd Length: 550  Bit Score: 142.70  E-value: 8.39e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAA--TIEARNHGVRVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGG-SIIRTSRTNpAR 80
Cdd:cd00765    75 IGIVLSGGQAPGGHNVISGLfdYLKERAKGSTLYGFKGGPAGILKCDY---IELNAEYIQPYRNTGGfDMICSGRTK-IE 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 TPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGLA----HVPKTIDNDLPLPSDIDTFGFSTACNLGKDL 156
Cdd:cd00765   151 TEDQFKQAEETAKKLDLDALVVIGGDDSNTNAALLAENFRSKGLKtrviGVPKTIDGDLKNKEIETSFGFDTATKIYSEL 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 157 VRNLMQDAATTER-WFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAIL 235
Cdd:cd00765   231 IGNVMRDARSTGKyWHFVKLMGRSASHIALECALKTHPNICIISEEVSAQKQTLKNITDYMVDVICKRAELGYNFGVVLV 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 236 SEGLAE-------------------------------------KLDLESLGPV--------------ERDQYGNVRLAEL 264
Cdd:cd00765   311 PEGLIEfipevkeliaelneilanevvefnglwkkklteqslkLFDLLPKGVYlplfieaiqeqlmlERDPHGNVQVSRI 390

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1125209119 265 DLGRVLKDRVAGRLRERKVDVTIVGK------DLGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNAMVTI 331
Cdd:cd00765   391 ETEKLLIQMVETRLEKMKQAGAYKGQfmgqshFFGYEGRCAFPSNFDADYCYALGYGAGVLLNSGKTGYISSV 463
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 4-351 3.33e-37

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 136.77  E-value: 3.33e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPARTPE 83
Cdd:cd00763     3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGD---IVPLDRYSVSDIINRGGTFLGSARFPEFKDEE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAK-ALPGLGLahvPKTIDNDLPlPSDIdTFGFSTACNLGKDLVRNLMQ 162
Cdd:cd00763    80 GQAKAIEQLKKHGIDALVVIGGDGSYMGAMRLTEhGFPCVGL---PGTIDNDIP-GTDY-TIGFDTALNTVVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 163 DAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEflesKITVDRLADILEGAIIKrrmhGRDHGVAILSEGLaek 242
Cdd:cd00763   155 TSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEA----EFDREEVANRIKAGIER----GKKHAIVVVAEGV--- 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 243 ldleslgpverdqYGNVrlaelDLGRVLKDRVAGRLRerkvdVTIvgkdLGYELRCAAPGAHDIQYSRSLGYWATRFLLE 322
Cdd:cd00763   224 -------------YDVD-----ELAKEIEEATGFETR-----ATV----LGHIQRGGSPTAFDRILASRMGAYAVELLLA 276

                         330       340       350
                  ....*....|....*....|....*....|
gi 1125209119 323 GGSNAMVTIQAGRLVPMPF-GLLLDPKTGK 351
Cdd:cd00763   277 GKGGLAVGIQNEQLVHHDIiDAIENMKPFK 306
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 3-369 1.42e-30

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 121.30  E-value: 1.42e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   3 TLAILVGGGPAPGINAVIAAATIEA-RNHGV-RVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGGSIIRTSRTnpar 80
Cdd:PTZ00286   89 KAGIVTCGGLCPGLNVVIRELVMNLiNNYGVkTIYGAKYGYKGLYKEDW---IKLDPKDVKTIHRLGGTILGSSRG---- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  81 tPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALP--GLGLAHV--PKTIDNDLPLpSDiDTFGFSTACNLGKDL 156
Cdd:PTZ00286  162 -GFDPKVMVDTLIRHGINILFTLGGDGTHRGALAIYKELRrrKLNISVVgiPKTIDNDIPI-ID-ESFGFQTAVEEAQNA 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 157 VRNLMQDAATTERWF-FVTVMGRRAGHLALGIGGAAGATLTVVAEEFlesKITVDRLADILEGAIIKRRmhgrdHGVAIL 235
Cdd:PTZ00286  239 IRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASADVNVCLIPEF---DIPLEGVLEYIEQRLQKKG-----HCVIVV 310

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 236 SEGLAEklDLESLGPV-ERDQYGNVRLaeLDLGRVLKDRVAGRLRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRSLGY 314
Cdd:PTZ00286  311 AEGAGQ--SLKDADLDlGTDASGNKKL--WDIGVYLKDEITKYLKKKKPEHTVKYIDPSYMIRAVPANAADAKFCTQLAQ 386

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125209119 315 WATRFLLEGGSNAMVTIQAGRLVPMPFglllDPKTGKIRvRYVDVESEMYQTLWA 369
Cdd:PTZ00286  387 NAVHGAMAGFTGFIIGHVHNNYVMIPI----KEMSGNYR-RRVNPEGRLWQRMLA 436
PLN02251 PLN02251
pyrophosphate-dependent phosphofructokinase
 4-323 4.85e-29

pyrophosphate-dependent phosphofructokinase


Pssm-ID: 215140  Cd Length: 568  Bit Score: 118.36  E-value: 4.85e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAA--TIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPART 81
Cdd:PLN02251   99 IGVVLSGGQAPGGHNVISGIfdYLQEHAKGSVLYGFKGGPAGIMKCK---YVELTAEFIYPYRNQGGFDMICSGRDKIET 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  82 PEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL-AHV---PKTIDNDLPLPSDIDTFGFSTACNLGKDLV 157
Cdd:PLN02251  176 PEQFKQAEETATKLDLDGLVVIGGDDSNTNACLLAEYFRAKNLkTRVigcPKTIDGDLKSKEVPTSFGFDTACKIYSEMI 255

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 158 RNLMQDAATTERWF-FVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAILS 236
Cdd:PLN02251  256 GNVMIDARSTGKYYhFVRLMGRAASHITLECALQTHPNITIIGEEVAAKKLTLKNVTDYIVDVICKRAELGYNYGVILIP 335

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 237 EGL-----------AE------------------KLDLESLG-----P--------VERDQYGNVRLAELDLGRVLKDRV 274
Cdd:PLN02251  336 EGLidfipevqhliAElneilahdvvdeeghwkkKLKPQSLQlfdflPhaiqeqlmLERDPHGNVQVAKIETEKMLIQMV 415

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1125209119 275 AGRLRERKVDVTIVGK------DLGYELRCAAPGAHDIQYSRSLGYWATRFLLEG 323
Cdd:PLN02251  416 ETELEKRKQEGSYKGHfkgqshFFGYEGRCGLPTNFDATYCYALGYGAGALLHSG 470
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
5-316 9.68e-28

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 113.04  E-value: 9.68e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAAATIEARNH-GV-RVLGCYDGFKWLVEGDTEHVVELTINDLSRIHFDGGSIIRTSrtnpaRTP 82
Cdd:PRK06830   84 AIVTCGGLCPGLNDVIRAIVLELHHHyGVrRILGIRYGYQGLIPRYGHDPVELTPEVVADIHEFGGTILGSS-----RGP 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  83 EGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL----AHVPKTIDNDLPLpsdID-TFGFSTACNLGKDLV 157
Cdd:PRK06830  159 QDPEEIVDTLERMNINILFVIGGDGTLRGASAIAEEIERRGLkisvIGIPKTIDNDINF---IQkSFGFETAVEKATEAI 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 158 RnlmqdAATTERWF------FVTVMGRRAGHlalgiggaagatltVVAEEFLESK------ITVDRLAdiLEG-----AI 220
Cdd:PRK06830  236 R-----CAHVEANGapngigLVKLMGRHSGF--------------IAAYAALASKdvnfvlIPEVPFD--LEGpngllAA 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 221 IKRRMHGRDHGVAILSEGLAEKLdLESLGpvERDQYGNVRLAelDLGRVLKDRVAGRLRERKVDVTIVGKDLGYELRCAA 300
Cdd:PRK06830  295 LEKRLAERGHAVIVVAEGAGQEL-FDDTG--ETDASGNPKLG--DIGLFLKDRIKEYFKARGIPINLKYIDPSYIIRSVP 369

                         330
                  ....*....|....*.
gi 1125209119 301 PGAHDIQYSRSLGYWA 316
Cdd:PRK06830  370 ANANDSVYCGFLGQNA 385
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 4-332 1.05e-23

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 103.19  E-value: 1.05e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119    4 LAILVGGGPAPGINAVIAAATIEAR--NHGVRVLGCYDGFKWLVegdTEHVVELTINDLSRIHFDGGSIIRTSRTNPART 81
Cdd:PTZ00287   180 IGIILSGGPAPGGHNVISGIYDYAKryNEQSQVIGFLGGIDGLY---SKNYVTITDSLMNRFRNLGGFNMLWSGRGKVRN 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   82 PEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVA-----KALPgLGLAHVPKTIDNDLPLPSDIDTFGFSTACNLGKDL 156
Cdd:PTZ00287   257 KDDLIAIENIVAKLKLNGLVIIGGDGSNSNAALISeyfaeRQIP-ISIIGIPKTIDGDLKSEAIEISFGFDTATKTYSEV 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  157 VRNLMQDAATTER-WFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAIL 235
Cdd:PTZ00287   336 IGNLCTDVKTGHNvYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSLKDIVSNIVNTILKRRSLNKNYGVILI 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  236 SEGL------------------------AEKLD-----LESLGPVERDQY-------GNVRLAELDLGR---VLKDRVAG 276
Cdd:PTZ00287   416 PEGLiefvpemkiligelnvilkegpfdASKLKhsrevWDFLPSIIRDQLlmdrestGYIQVGKIATERliiVLVESELA 495

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125209119  277 RLRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNAMVTIQ 332
Cdd:PTZ00287   496 KLNDNNLNIQFMAHYLGYEGRCAIPSNFDCNYCYALGYNAALLIDHKKTGYMSIIQ 551
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 2-338 1.62e-23

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 102.75  E-value: 1.62e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119    2 RTLAILVGGGPAPGINAVIAA--ATIEARNHGVRVLGCYDGfkwlVEG-DTEHVVELTINDLSRIHFDGGSIIRTSRTNP 78
Cdd:PTZ00468   103 RRIGVVLSGGQASGGHNVIAGlmSYIKLCNQSSQLFGFLGG----PEGvYSERYRELTEDDINGILNQGGFNIICSGRHK 178

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   79 ARTPEGVG---RVAETLKRHGvdyLITIGGDDTAFAASRVAKALPGLGLAHV----PKTIDNDLPLPSDIDTFGFSTACN 151
Cdd:PTZ00468   179 IETEEQMRaslEICEKLKLHG---LVVIGGDDSNTNAAVLAEYFKRNSSSTVvvgcPKTIDGDLKNEVIETSFGYDTAVK 255

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  152 LGKDLVRNLMqDAATTER--WFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRD 229
Cdd:PTZ00468   256 TYSEQIGSIM-DAIKTEGygYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSLMSIVDEIVEMILKRDSLGKK 334

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  230 HGVAILSEGLAEKL----------------------------------------DLESLGPVERDQYGNVRLAELDLGRV 269
Cdd:PTZ00468   335 HGIVLLPEGLIEFIpefetlikelnlillktndrkqiidslsqemktlflelpsDVQNQLLLERDPHGNVQVAKIATEEL 414

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1125209119  270 LKDRVAGRLRErkvdvtiVGKD----------LGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNAMVTIQAGRLVP 338
Cdd:PTZ00468   415 LVHMAKEKLEE-------VKKDyildnvkthyFGYEGRCALPSNFDASYCFALGHTAAALIDNQRSGYMAVVRKLSLTP 486
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
1-332 4.85e-21

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 93.77  E-value: 4.85e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAATIEARNHGV--RVLGCYDGFKWLVEGDTEHVVELTINDLSRIHFDGGSIIRTSR--- 75
Cdd:PRK14072    3 KGNALYAQSGGPTAVINASAAGVIEEARKHKKigKVYGARNGIIGILDEDLIDLSKESDEALAALAHTPSGALGSCRykl 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  76 TNPARTPEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGLA----HVPKTIDNDLPLpsdID-TFGFSTAC 150
Cdd:PRK14072   83 KSLEEDRAEYERLLEVFKAHDIGYFFYNGGNDSMDTALKVSQLAKKMGYPirciGIPKTIDNDLPG---TDhCPGFGSAA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 151 NLGKDLVRNLMQDAA---TTERWFFVTVMGRRAGHlalgiggaagatLTV---VAEEFLES--------KITVDR---LA 213
Cdd:PRK14072  160 KYIATSVLEAALDVAamaNTSKVFILEVMGRHAGW------------LAAaaaLAKQNPDDaphliylpERPFDEekfLA 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 214 DIleGAIIKRrmHGRdhGVAILSEGLAEKlD---LESLGPVErDQYGNVRLAelDLGRVLKDRVAGRLRER-KVDVtivg 289
Cdd:PRK14072  228 DV--RAIVKR--YGY--CVVVVSEGIRDA-DgkfIAEAGLAE-DAFGHAQLG--GVAPVLANLIKEKLGKKvHWAV---- 293

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1125209119 290 kdLGYELRCAapgAH-----DIQYSRSLGYWATRFLLEGGSNAMVTIQ 332
Cdd:PRK14072  294 --LDYLQRAA---RHiasktDVEEAYAVGKAAVEYALAGKNGVMPAIR 336
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 4-241 8.21e-20

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 91.25  E-value: 8.21e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   4 LAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPARtpe 83
Cdd:TIGR02478 392 IAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD---VRELTWSDVEGWVGEGGSELGTNRSLPGD--- 465

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 GVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKA--------LPglgLAHVPKTIDNDLPlPSDIdTFGFSTACNLGKD 155
Cdd:TIGR02478 466 DLGTIAYYFQQHKIDGLIIIGGFEAFEALYQLDAArekypafrIP---MVVIPATISNNVP-GTEY-SLGSDTALNEITE 540

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 156 LVRNLMQDA-ATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEflesKITVDRLA-DILEgaiIKRRM-HGRDHGV 232
Cdd:TIGR02478 541 YCDNIKQSAsASKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEE----GISLKDLQeDIEH---LKETFaEGRAGKL 613


                  ....*....
gi 1125209119 233 AILSEGLAE 241
Cdd:TIGR02478 614 ILRNEKASK 622
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 2-340 1.56e-19

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 90.48  E-value: 1.56e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   2 RTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtEHVVELTINDLSRIHFDGGSIIRTSRTNPART 81
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGG-DNIEEAQWEDVRGILSLGGTIIGTARCKEFRE 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  82 PEGVGRVAETLKRHGVDYLITIGGDDTAFAA---------------------SRVAKALPGLGLAHVPKTIDNDLPlPSD 140
Cdd:TIGR02478  80 RPGRLKAARNLVSNGIDALVVIGGDGSLTGAdlfreewpslleelvdtgkitAEQAEEHRHLTIVGLVGSIDNDMC-GTD 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 141 IdTFGFSTACNLGKDLVRNLMQDAATTERWFFVTVMGRRAGHlalgiggaagatLTVVAEE-------FLESKITVDRLA 213
Cdd:TIGR02478 159 M-TIGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGY------------LALMAAIatgadyvFIPERPPEEGWE 225

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 214 DILEGAIIKRRMHGRDHGVAILSEGLAEKldleSLGPVERDQYGNVRLAELDLgrvlkdrvagrlrerKVDVTIvgkdLG 293
Cdd:TIGR02478 226 DQLCHKLKRNRKAGKRKTIVIVAEGAIDR----DLNPITSEDVKDVLVERLGL---------------DTRITV----LG 282

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1125209119 294 YELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNA---MVTIQAGRLVPMP 340
Cdd:TIGR02478 283 HVQRGGAPSAFDRILATRQGVEAVLAVLESTPETpspVISLRGNKIVRKP 332
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
2-340 1.37e-18

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 85.89  E-value: 1.37e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   2 RTLAILVGGGPAPGINAVIAAATIEAR-NHGVRVLGCYDGFKWLVEgDTEHVVELTINDLSRIHFDGGSII-RTSRTNPA 79
Cdd:PRK14071    5 KRIGILTSGGDCAGLNAVIRAVVHRARgTYGWEVIGIRDATQGLMA-RPPQYIELDLDQVDDLLRMGGTILgTTNKGDPF 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  80 RTPEGVG-------RVAETLKRHGVDYLITIGGDDTaFAASRVAKALPGLGLAHVPKTIDNDLPLPSDidTFGFSTACNL 152
Cdd:PRK14071   84 AFPMPDGslrdrsqEIIDGYHSLGLDALIGIGGDGS-LAILRRLAQQGGINLVGIPKTIDNDVGATEV--SIGFDTAVNI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 153 GKDLVRNLMQDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAeeflESKITVDRLADIlegaIIKRRMHGRDHGV 232
Cdd:PRK14071  161 ATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIP----EIPYTLENVCKK----IRERQEEGKNFCL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 233 AILSEGLaekLDLESLGPVERDQYGNVRLAelDLGRVLKDRVAGRL-RERKVDVtivgkdLGYELRCAAPGAHDIQYSRS 311
Cdd:PRK14071  233 VVVSEAV---RTEEGEQVTKTQALGEDRYG--GIGQYLAEQIAERTgAETRVTV------LGHIQRGGIPSPRDRLLASA 301

                         330       340
                  ....*....|....*....|....*....
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMP 340
Cdd:PRK14071  302 FGVAAVDLIAQGKFDRMVAWQNRQVVSVP 330
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 1-325 5.14e-18

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 84.67  E-value: 5.14e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   1 MRTLAILVGGGPAPGINAVIAAaTIEARNH---GVRVLGCYDGFKWLVEGDTehvveLTINDLSR-----IHFDGGSIIR 72
Cdd:PRK06555    3 VKKVALLTAGGLAPCLSSAVGG-LIERYTEiapEVEIIAYRSGYQGLLLGDS-----IEITPAVRanaglLHRYGGSPIG 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  73 TSRTNPARTPEGVGR------------VAETLKRHGVDYLITIGGDDTAFAASRVAKALP--GLGLAHV--PKTIDNDL- 135
Cdd:PRK06555   77 NSRVKLTNVADCVKRglvkegenplkvAAERLAADGVDILHTIGGDDTNTTAADLAAYLAenGYDLTVVglPKTIDNDVv 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 136 PLPSdidTFGFSTACNLGKDLVRNLMQDAATTERWFFV-TVMGRRAGHLALGIGGAAGATLtvVAEEFLESKITVDRLAD 214
Cdd:PRK06555  157 PIRQ---SLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARAYREWL--DRQEYVPGFGLSAERWD 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 215 I-------------LEGAIIKRRMHGRDHGVAILSEG------LAEkldLESLG-PVERDQYGNVRLAELDLGRVLKDRV 274
Cdd:PRK06555  232 IhavylpemafdleAEAERLKAVMDEVGNVNIFLSEGagldaiVAE---MEAAGeEVKRDAFGHVKLDTINPGAWFAKQF 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1125209119 275 AGRLRERKvdvTIVGKDlGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGS 325
Cdd:PRK06555  309 AELLGAEK---VMVQKS-GYFARSAPANAEDLRLIKSMVDLAVECALRGVS 355
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 2-340 2.77e-15

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 77.56  E-value: 2.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   2 RTLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtEHVVELTINDLSRIHFDGGSIIRTSRTNPART 81
Cdd:cd00764     4 KAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGG-DYIKQAEWESVSNWLQEGGTIIGSARCKEFRE 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  82 PEGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGL---------------------GLAHVPKTIDNDLplpSD 140
Cdd:cd00764    83 REGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLleelvkdgkiteeevakyqhlNIVGMVGSIDNDF---CG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 141 ID-TFGFSTACNLGKDLVRNLMQDAATTERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITvDRLADILEga 219
Cdd:cd00764   160 TDmTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWE-DQMCRRLS-- 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 220 iiKRRMHGRDHGVAILSEGLAEKldleSLGPVERDQYGNVRLAELDLgrvlkdrvagrlrerKVDVTIvgkdLGYELRCA 299
Cdd:cd00764   237 --EHRSRGKRLNIIIVAEGAIDD----QLKPITSEDVKDLVVERLGL---------------DTRVTT----LGHVQRGG 291

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1125209119 300 APGAHDIQYSRSLGYWATRFLLEGGSNA---MVTIQAGRLVPMP 340
Cdd:cd00764   292 TPSAFDRILASLMGVEAVMALLEATPDTpacVVSLNGNKAVRLP 335
PLN02564 PLN02564
6-phosphofructokinase
 5-341 1.40e-14

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 74.78  E-value: 1.40e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAAATIEARN-HGV-RVLGCYDGFKWLVEGDTEHVVELTINDlsrIHFDGGSIIRTSRTNpartp 82
Cdd:PLN02564   91 CIVTCGGLCPGLNTVIREIVCGLSYmYGVtRILGIDGGYRGFYSRNTIPLTPKVVND---IHKRGGTILGTSRGG----- 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  83 EGVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL----AHVPKTIDNDLPLpsdID-TFGFSTACNLGKDLV 157
Cdd:PLN02564  163 HDTSKIVDSIQDRGINQVYIIGGDGTQKGASVIYEEIRRRGLkvavAGIPKTIDNDIPV---IDkSFGFDTAVEEAQRAI 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 158 RNLMQDAATTERWF-FVTVMGRRAGHLALGIGGAAGATLTVVAEE---FLESKitvdrlADILEgaIIKRRMHGRDHGVA 233
Cdd:PLN02564  240 NAAHVEAESVENGIgLVKLMGRYSGFIAMYATLASRDVDCCLIPEspfYLEGK------GGLFE--FIEKRLKENGHMVI 311

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 234 ILSEGLAEKLDLESLGPVE-RDQYGNVRLaeLDLGRVLKDRVAGR-LRERKVDVTIVGKDLGYELRCAAPGAHDIQYSRS 311
Cdd:PLN02564  312 VVAEGAGQDLIAESMESSDlQDASGNKLL--LDVGLWLSQKIKDHfTKVKKMPINLKYIDPTYMIRAIPSNASDNVYCTL 389

                         330       340       350
                  ....*....|....*....|....*....|
gi 1125209119 312 LGYWATRFLLEGGSNAMVTIQAGRLVPMPF 341
Cdd:PLN02564  390 LAHSAVHGAMAGYTGFTVGPVNGRHAYIPF 419
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 3-182 1.54e-14

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 75.24  E-value: 1.54e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   3 TLAILVGGGPAPGINAVIAAATIEARNHGVRVLGCYDGFKWLVEGDtehVVELTINDLSRIHFDGGSIIRTSRTNPArtp 82
Cdd:cd00764   391 NIAIVNVGAPAAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQ---IVELGWIDVGGWTGRGGSELGTKRTLPK--- 464

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  83 EGVGRVAETLKRHGVDYLITIGGDDtAFAA----SRVAKALPGLGLAHV--PKTIDNDLPlPSDIdTFGFSTACNLGKDL 156
Cdd:cd00764   465 KDLETIAYNFQKYGIDGLIIVGGFE-AYKGllqlREAREQYEEFCIPMVliPATVSNNVP-GTDF-SLGSDTALNALMKY 541

                         170       180
                  ....*....|....*....|....*..
gi 1125209119 157 VRNLMQDAATTE-RWFFVTVMGRRAGH 182
Cdd:cd00764   542 CDRIKQSASGTKrRVFIVETMGGYCGY 568
PLN03028 PLN03028
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 10-331 2.10e-14

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 215543  Cd Length: 610  Bit Score: 74.43  E-value: 2.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  10 GGPAPGINAVIAAA--TIEARNHGVRVLGCYDGFKWLVEGDTehvVELTINDLSRIHFDGGSIIRTSRTNPARTPEGVGR 87
Cdd:PLN03028   88 GRQSPGGHNVIWGLhdALKAHNPNSVLLGFLGGTEGLFAQKT---LEITDDVLSTYKNQGGYDLLGRTKDQIRTTEQVNA 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  88 VAETLKRHGVDYLITIGG----DDTAFAASRVAKALPGLGLAHVPKTIDNDLPLPSDIDTFGFSTACNLGKDLVRNLMQD 163
Cdd:PLN03028  165 ALAACEALKLDGLVIIGGvtsnTDAAQLAETFAEAKCKTKVVGVPVTLNGDLKNQFVETNVGFDTICKVNSQLISNVCTD 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 164 AATTERWF-FVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAILSEGLAEK 242
Cdd:PLN03028  245 ALSAEKYYyFIRLMGRKASHVALECALQSHPNMVILGEEVAASKLTLFDITKQICDAVQARAEQDKNHGVILIPEGLIES 324

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119 243 LD---------------------------------LESLGPVERDQY-------GNVRLAELDLGRVLKDRVAGRLRERK 282
Cdd:PLN03028  325 IPevyallqeihgllkqgvsvdnissqlspwasalFEFLPPFIKKQLllhpesdDSAQLSQIETEKLLAQLVETEMNKRT 404

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1125209119 283 VDVTIVGKD-------LGYELRCAAPGAHDIQYSRSLGYWATRFLLEGGSNAMVTI 331
Cdd:PLN03028  405 KEGTYKGKKfnaichfFGYQARGSLPSKFDCDYAYVLGHICYHILAAGLNGYMATV 460
PLN02884 PLN02884
6-phosphofructokinase
 5-181 6.00e-12

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 66.37  E-value: 6.00e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   5 AILVGGGPAPGINAVIAAATIEARNHGVR-VLGCYDGFKWLVEgDTEHVVELTINDLSRIHFDGGSIIRTSRTNPArtpe 83
Cdd:PLN02884   57 AIVTCGGLCPGLNDVIRQIVFTLEIYGVKnIVGIPFGYRGFFE-KGLSEMPLSRKVVQNIHLSGGSLLGVSRGGAK---- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  84 gVGRVAETLKRHGVDYLITIGGDDTAFAASRVAKALPGLGL----AHVPKTIDNDLPLpsdID-TFGFSTACNLGKDLVR 158
Cdd:PLN02884  132 -TSDIVDSIEARGINMLFVLGGNGTHAGANAIHNECRKRKMkvsvVGVPKTIDNDILL---MDkTFGFDTAVEEAQRAIN 207

                         170       180
                  ....*....|....*....|....
gi 1125209119 159 NLMQDAATTERWF-FVTVMGRRAG 181
Cdd:PLN02884  208 SAYIEAHSAYHGIgLVKLMGRSSG 231
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 83-239 2.83e-05

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 46.18  E-value: 2.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119   83 EGVGRVAETLKRHGVDYLITIGGDDTAFAASRVA-----KALPgLGLAHVPKTIDNDLpLPSDIDT-FGFSTACNLGKDL 156
Cdd:PTZ00287   915 ENRNKVCETVTNLQLNGLVMPGSNVTITEAALLAeyfleKKIP-TSVVGIPLTGSNNL-IHELIETcVGFDSSTKVYASL 992

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  157 VRNLMQDAATTER-WFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLESKITVDRLADILEGAIIKRRMHGRDHGVAIL 235
Cdd:PTZ00287   993 IGNVLTDAVSMPKyWHFIRLMGRSPSHEVLECALQTHPNMVIISEEYGAADKTLWRVVQDIADVVCARAELGKNYGTVLI 1072


                   ....
gi 1125209119  236 SEGL 239
Cdd:PTZ00287  1073 PDAL 1076
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 127-243 4.66e-04

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 42.27  E-value: 4.66e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1125209119  127 VPKTIDNDLPLPSdIDT-FGFSTACNLGKDLVRNLMQDAAT-TERWFFVTVMGRRAGHLALGIGGAAGATLTVVAEEFLE 204
Cdd:PTZ00468   840 VPVCLENSISHQM-IETcIGFDSVTKSISTLVGNLLTDSASaTKYWYFMKMIGDKTSNVALEVGIQTHPNLVVIPERYAD 918

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1125209119  205 SK----------ITVDRLADILEGAIIKRRMHGRDHGVAILSEGLAEKL 243
Cdd:PTZ00468   919 SKlsvygsemagVTLDDIITEICDIICLRSNQGNNFGGLLVSEGLFDQV 967
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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