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Conserved domains on  [gi|1121109941|ref|XP_019544657|]
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nucleoporin Nup43 [Aedes albopictus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-293 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  14 SEKVSRIRWIPEqydeSSSFITGSWDlavNNLKVWKLVRNdyaddenefvpKCTAE-VCFTGDISGLEFVDERSVVLSSt 92
Cdd:cd00200    51 TGPVRDVAASAD----GTYLASGSSD---KTIRLWDLETG-----------ECVRTlTGHTSYVSSVAFSPDGRILSSS- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  93 egfvsliGLDRekdednlqeRHRFDGLHKFDTFSSLNA--APCTGLSVHDTD--VATVGEDGRLNVVSTVGLKVLRSIAS 168
Cdd:cd00200   112 -------SRDK---------TIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGtfVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 169 ADSCtISCVAFL-NPKEVLTGNRLGIIKCFDIRAegQKAVGSFavscedEKRSNCVTCIAYHPTqRHIILAGSEEGSITV 247
Cdd:cd00200   176 HTGE-VNSVAFSpDGEKLLSSSSDGTIKLWDLST--GKCLGTL------RGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1121109941 248 WDLRQPQFPASyLKAHDHAISELAFHRTqPSRLFSASEGGELWQWN 293
Cdd:cd00200   246 WDLRTGECVQT-LSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-293 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  14 SEKVSRIRWIPEqydeSSSFITGSWDlavNNLKVWKLVRNdyaddenefvpKCTAE-VCFTGDISGLEFVDERSVVLSSt 92
Cdd:cd00200    51 TGPVRDVAASAD----GTYLASGSSD---KTIRLWDLETG-----------ECVRTlTGHTSYVSSVAFSPDGRILSSS- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  93 egfvsliGLDRekdednlqeRHRFDGLHKFDTFSSLNA--APCTGLSVHDTD--VATVGEDGRLNVVSTVGLKVLRSIAS 168
Cdd:cd00200   112 -------SRDK---------TIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGtfVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 169 ADSCtISCVAFL-NPKEVLTGNRLGIIKCFDIRAegQKAVGSFavscedEKRSNCVTCIAYHPTqRHIILAGSEEGSITV 247
Cdd:cd00200   176 HTGE-VNSVAFSpDGEKLLSSSSDGTIKLWDLST--GKCLGTL------RGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1121109941 248 WDLRQPQFPASyLKAHDHAISELAFHRTqPSRLFSASEGGELWQWN 293
Cdd:cd00200   246 WDLRTGECVQT-LSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
143-296 1.13e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 143 VATVGEDGRLNVVSTVGLKVLRSIaSADSCTISCVAFlNP--KEVLTGNRLGIIKCFDIRAegQKAVGSFavscedEKRS 220
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLAT--GKLLRTL------TGHT 204

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1121109941 221 NCVTCIAYHPTQRHIIlAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHRtQPSRLFSASEGGELWQWNQNT 296
Cdd:COG2319   205 GAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRT-LTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT 277
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-293 1.24e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  14 SEKVSRIRWIPEqydeSSSFITGSWDlavNNLKVWKLVRNdyaddenefvpKCTAE-VCFTGDISGLEFVDERSVVLSSt 92
Cdd:cd00200    51 TGPVRDVAASAD----GTYLASGSSD---KTIRLWDLETG-----------ECVRTlTGHTSYVSSVAFSPDGRILSSS- 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941  93 egfvsliGLDRekdednlqeRHRFDGLHKFDTFSSLNA--APCTGLSVHDTD--VATVGEDGRLNVVSTVGLKVLRSIAS 168
Cdd:cd00200   112 -------SRDK---------TIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGtfVASSSQDGTIKLWDLRTGKCVATLTG 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 169 ADSCtISCVAFL-NPKEVLTGNRLGIIKCFDIRAegQKAVGSFavscedEKRSNCVTCIAYHPTqRHIILAGSEEGSITV 247
Cdd:cd00200   176 HTGE-VNSVAFSpDGEKLLSSSSDGTIKLWDLST--GKCLGTL------RGHENGVNSVAFSPD-GYLLASGSEDGTIRV 245

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1121109941 248 WDLRQPQFPASyLKAHDHAISELAFHRTqPSRLFSASEGGELWQWN 293
Cdd:cd00200   246 WDLRTGECVQT-LSGHTNSVTSLAWSPD-GKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
143-296 1.13e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 56.46  E-value: 1.13e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 143 VATVGEDGRLNVVSTVGLKVLRSIaSADSCTISCVAFlNP--KEVLTGNRLGIIKCFDIRAegQKAVGSFavscedEKRS 220
Cdd:COG2319   135 LASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAF-SPdgKLLASGSDDGTVRLWDLAT--GKLLRTL------TGHT 204

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1121109941 221 NCVTCIAYHPTQRHIIlAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHRtQPSRLFSASEGGELWQWNQNT 296
Cdd:COG2319   205 GAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLRT-LTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLAT 277
WD40 COG2319
WD40 repeat [General function prediction only];
143-305 3.25e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 3.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 143 VATVGEDGRLNVVSTVGLKVLRSIASADScTISCVAFlNP--KEVLTGNRLGIIKCFDirAEGQKAVGSFavscedEKRS 220
Cdd:COG2319   219 LASGSADGTVRLWDLATGKLLRTLTGHSG-SVRSVAF-SPdgRLLASGSADGTVRLWD--LATGELLRTL------TGHS 288

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 221 NCVTCIAYHPTQRHIIlAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHRtQPSRLFSASEGGELWQWNQNTLPTG 300
Cdd:COG2319   289 GGVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRT-LTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELL 365


                  ....*
gi 1121109941 301 ASATG 305
Cdd:COG2319   366 RTLTG 370
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 143-305 2.37e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 2.37e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 143 VATVGEDGRLNVVSTVGLKVLRSIASADSCTISCVAFLNPKEVLTGNRLGIIKCFDIraEGQKAVGSFAVSCEDekrsnc 222
Cdd:cd00200    24 LATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL--ETGECVRTLTGHTSY------ 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 223 VTCIAYHPTqRHIILAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHRTQpSRLFSASEGGELWQWNQNTLPTGAS 302
Cdd:cd00200    96 VSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTT-LRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLWDLRTGKCVAT 172


                  ...
gi 1121109941 303 ATG 305
Cdd:cd00200   173 LTG 175
WD40 COG2319
WD40 repeat [General function prediction only];
136-305 6.38e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.60  E-value: 6.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 136 LSVHDTDVATVGEDGRLNVVSTVGLKVLRSIASADSCTISCVAFLNPKEVLTGNRLGIIKCFDIRAEGQKAVGsfavsce 215
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTL------- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 216 dEKRSNCVTCIAYHPTQRhIILAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHrtqP--SRLFSASEGGELWQWN 293
Cdd:COG2319   117 -TGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLATGKLLRT-LTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWD 190

                         170
                  ....*....|..
gi 1121109941 294 QNTLPTGASATG 305
Cdd:COG2319   191 LATGKLLRTLTG 202
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 223-296 4.03e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 4.03e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1121109941 223 VTCIAYHPTQRHIiLAGSEEGSITVWDLRQPQFPASyLKAHDHAISELAFHRTQPsRLFSASEGGELWQWNQNT 296
Cdd:cd00200    12 VTCVAFSPDGKLL-ATGSGDGTIKVWDLETGELLRT-LKGHTGPVRDVAASADGT-YLASGSSDKTIRLWDLET 82
WD40 COG2319
WD40 repeat [General function prediction only];
143-251 3.66e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.12  E-value: 3.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1121109941 143 VATVGEDGRLNVVSTVGLKVLRSIaSADSCTISCVAFL-NPKEVLTGNRLGIIKCFDIraEGQKAVGSFavscedEKRSN 221
Cdd:COG2319   303 LASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpDGKTLASGSDDGTVRLWDL--ATGELLRTL------TGHTG 373

                          90       100       110
                  ....*....|....*....|....*....|
gi 1121109941 222 CVTCIAYHPTQRHIIlAGSEEGSITVWDLR 251
Cdd:COG2319   374 AVTSVAFSPDGRTLA-SGSADGTVRLWDLA 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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