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Conserved domains on  [gi|111955326|ref|NP_055753|]
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MLX-interacting protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.78e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


:

Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.78e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 111955326 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 718-787 2.83e-42

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


:

Pssm-ID: 381531  Cd Length: 72  Bit Score: 148.17  E-value: 2.83e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLISNN--SKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd19688    1 KNRRMKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 294-715 3.28e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  294 PVAWPNPREIAHLGNADMIQPGlIPLQPNldfmDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPAQESILP---T 370
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPD-APPQSA----RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDphpP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  371 TALPTVSLPDSLIAPPTA-----------PSLAHMDEQGceHTSRTEDPFIQP-TDFGPSEPPLSVPQPFLPVFTmplls 438
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVsrprrarrlgrAAQASSPPQR--PRRRAARPTVGSlTSLADPPPPPPTPEPAPHALV----- 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  439 pSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSvithtasatlthdaPATTfsqsqglvITTHHPAPSA 518
Cdd:PHA03247 2717 -SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--------------PPTT--------AGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  519 APCGlalspvtrPPQPRLTfvHPKPVSLTGGRPKQPHKIVPAPKPEPVS--LVLKNARIAPAAF-----SGQPQAVIMTS 591
Cdd:PHA03247 2774 APAA--------GPPRRLT--RPAVASLSESRESLPSPWDPADPPAAVLapAAALPPAASPAGPlppptSAQPTAPPPPP 2843

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  592 GPLKREGMLASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLghgtssPPAPVSRLFPSTAQDPLgkGEQVPLHGGSPQ 671
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL------ARPAVSRSTESFALPPD--QPERPPQPQAPP 2915

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 111955326  672 VTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVA 715
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959
 
Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.78e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.78e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 111955326 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 718-787 2.83e-42

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 148.17  E-value: 2.83e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLISNN--SKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd19688    1 KNRRMKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
HLH pfam00010
Helix-loop-helix DNA-binding domain;
720-770 1.36e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 54.39  E-value: 1.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 111955326  720 RQMKHISAEQKRRFNIKMCFDMLNSLI---SNNSKLtSHAITLQKTVEYITKLQ 770
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLptlPPDKKL-SKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
727-772 2.39e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 53.76  E-value: 2.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 111955326   727 AEQKRRFNIKMCFDMLNSLI---SNNSKLtSHAITLQKTVEYITKLQQE 772
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLptlPKNKKL-SKAEILRLAIEYIKSLQEE 50
PHA03247 PHA03247
large tegument protein UL36; Provisional
 294-715 3.28e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  294 PVAWPNPREIAHLGNADMIQPGlIPLQPNldfmDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPAQESILP---T 370
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPD-APPQSA----RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDphpP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  371 TALPTVSLPDSLIAPPTA-----------PSLAHMDEQGceHTSRTEDPFIQP-TDFGPSEPPLSVPQPFLPVFTmplls 438
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVsrprrarrlgrAAQASSPPQR--PRRRAARPTVGSlTSLADPPPPPPTPEPAPHALV----- 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  439 pSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSvithtasatlthdaPATTfsqsqglvITTHHPAPSA 518
Cdd:PHA03247 2717 -SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--------------PPTT--------AGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  519 APCGlalspvtrPPQPRLTfvHPKPVSLTGGRPKQPHKIVPAPKPEPVS--LVLKNARIAPAAF-----SGQPQAVIMTS 591
Cdd:PHA03247 2774 APAA--------GPPRRLT--RPAVASLSESRESLPSPWDPADPPAAVLapAAALPPAASPAGPlppptSAQPTAPPPPP 2843

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  592 GPLKREGMLASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLghgtssPPAPVSRLFPSTAQDPLgkGEQVPLHGGSPQ 671
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL------ARPAVSRSTESFALPPD--QPERPPQPQAPP 2915

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 111955326  672 VTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVA 715
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959
 
Name Accession Description Interval E-value
NES2-NLS_MLXIP cd21772
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 4.78e-90

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in MLX-interacting protein (MLXIP), and similar proteins; MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. It binds DNA by forming a heterodimer with Max-like protein (MLX) and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. MLXIP may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439288  Cd Length: 117  Bit Score: 281.18  E-value: 4.78e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 200
Cdd:cd21772    1 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSVDVDEHRR 80

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 111955326 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21772   81 PEAIATEGKYWKRRIEIVIREYHKWRTYFKKRLQKHK 117
NES2-NLS_ChREBP cd21771
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-237 5.41e-73

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), and similar proteins; ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a large transcription factor that functions at two levels, nuclear localization and DNA binding. It binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. ChREBP contains functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439287  Cd Length: 116  Bit Score: 235.25  E-value: 5.41e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLDGSvDVDEHRR 200
Cdd:cd21771    1 SIDPTLTRLFECMSLAYSGKLVSPKWKNFKGLRLLWRDKIRLNNAIWRAWYIQYVEKRKNPVCGFVTPLEGS-EADEHRK 79

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 111955326 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHK 237
Cdd:cd21771   80 PEAVVLEGNYWKRRIEVVMKEYHKWRIYYKKRLRKSS 116
NES2-NLS_ChREBP-like cd21739
nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in ...
 121-233 3.49e-67

nuclear export signal 2 (NES2) and nuclear import signal (NLS) domains found in carbohydrate-responsive element-binding protein (ChREBP), MLX-interacting protein (MLXIP), and similar proteins; This family includes two transcription factors: ChREBP and MLXIP. ChREBP, also called class D basic helix-loop-helix protein 14 (bHLHd14), Max-like protein (MLX) interactor or MIO, MLX-interacting protein-like (MLXIPL), WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), functions at two levels; nuclear localization and DNA binding. ChREBP binds to the canonical and non-canonical E box sequences 5'-CACGTG-3'. It also binds DNA as a heterodimer with TCFL4/MLX. MLXIP, also called class E basic helix-loop-helix protein 36 (bHLHe36), transcriptional activator MondoA, or MIR, is a novel basic helix-loop-helix-leucine zipper transcriptional activator that constitutes a positive branch of a max-like network. MLXIP binds DNA by forming a heterodimer with Max-like protein (MLX), and activates transcription. It binds to the canonical E box sequence 5'-CACGTG-3'. MLXIP plays a role in transcriptional activation of glycolytic target genes and is involved in glucose-responsive gene regulation. Members in this family may contain functional domains, including two nuclear export signals, NES1 and NES2, and a nuclear import signal (NLS) in the N-terminal region. This model corresponds to NES2 and NLS domains.


Pssm-ID: 439286  Cd Length: 113  Bit Score: 219.44  E-value: 3.49e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 121 SIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRKNPVCHFVTPLdgsvDVDEHRR 200
Cdd:cd21739    1 AIDESLTKLFKCLTLAYSGKLTSPKWKNFKGLKLRWKDKIRLNNAIWREWHMQFVKKKKPPVCQFAVPL----DDDTHKK 76

                         90       100       110
                 ....*....|....*....|....*....|...
gi 111955326 201 PEAITTEGKYWKSRIEIVIREYHKWRTYFKKRL 233
Cdd:cd21739   77 PEAVVLEGKYWKRRLETVVREYKKWRLFYKDKL 109
bHLHzip_MLXIP cd19688
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and ...
 718-787 2.83e-42

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP) and similar proteins; MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm.


Pssm-ID: 381531  Cd Length: 72  Bit Score: 148.17  E-value: 2.83e-42
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLISNN--SKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd19688    1 KNRRMKHISAEQKRRFNIKICFDTLNSLVSTLknSKPISNAITLQKTVEYIAKLQQERTQMQEETKRLREEI 72
bHLHzip_MLXIP_like cd11405
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), ...
 718-787 8.98e-32

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein (MLXIP), MLX-interacting protein-like (MLXIPL) and similar proteins; The family includes MLXIP and MLXIPL. MLXIP, also termed Class E basic helix-loop-helix protein 36 (bHLHe36), or transcriptional activator MondoA, is a bHLHZip transcriptional activator that binds DNA as a heterodimer with Mlx. It binds to the canonical E box sequence 5'-CACGTG-3' and plays a role in transcriptional activation of glycolytic target genes. MLXIP is most highly expressed in skeletal muscle and functions as an indirect glucose sensor, by sensing glucose 6-phosphate and shuttling between the nucleus and the cytoplasm. MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381411 [Multi-domain]  Cd Length: 74  Bit Score: 118.15  E-value: 8.98e-32
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLISN-----NSKLtSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd11405    1 EQRRLSHISAEQKRRFNIKSGFDTLQSLIPSlgqnpNQKV-SKAAMLQKAAEYIKSLKRERQQMQEEAEQLRQEI 74
bHLHzip_MLXIPL cd19689
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) ...
 718-787 1.62e-25

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MLX-interacting protein-like (MLXIPL) and similar proteins; MLXIPL, also termed carbohydrate-responsive element-binding protein (ChREBP), or Class D basic helix-loop-helix protein 14 (bHLHd14), or MLX interactor, or WS basic-helix-loop-helix leucine zipper protein (WS-bHLH), or Williams-Beuren syndrome chromosomal region 14 protein (WBSCR14), is a bHLHZip transcriptional factor integral to the regulation of glycolysis and lipogenesis in the liver. It forms heterodimers with the bHLHZip protein Mlx to bind the DNA sequence 5'-CACGTG-3'.


Pssm-ID: 381532  Cd Length: 76  Bit Score: 100.43  E-value: 1.62e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLISN----NSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd19689    3 ETRRITHISAEQKRRFNIKLGFDTLHSLVTTlssqPSIKISKATTLQKTAEYISKLQQERAQLQEEAQRLRDQI 76
bHLHzip_Mlx cd19687
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar ...
 719-787 4.50e-11

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) and similar proteins; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription.


Pssm-ID: 381530 [Multi-domain]  Cd Length: 76  Bit Score: 59.36  E-value: 4.50e-11
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 111955326 719 NRQMKHISAEQKRRFNIKMCFDMLNSLI-------SNNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEI 787
Cdd:cd19687    1 RRREAHTQAEQKRRDAIKKGYDDLQDIVptcqqqdDIGSQKLSKATILQRSIDYIQFLHQQKKKQEEELSALRKEV 76
HLH pfam00010
Helix-loop-helix DNA-binding domain;
720-770 1.36e-09

Helix-loop-helix DNA-binding domain;


Pssm-ID: 459628 [Multi-domain]  Cd Length: 53  Bit Score: 54.39  E-value: 1.36e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 111955326  720 RQMKHISAEQKRRFNIKMCFDMLNSLI---SNNSKLtSHAITLQKTVEYITKLQ 770
Cdd:pfam00010   1 RREAHNERERRRRDRINDAFDELRELLptlPPDKKL-SKAEILRLAIEYIKHLQ 53
HLH smart00353
helix loop helix domain;
727-772 2.39e-09

helix loop helix domain;


Pssm-ID: 197674 [Multi-domain]  Cd Length: 53  Bit Score: 53.76  E-value: 2.39e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 111955326   727 AEQKRRFNIKMCFDMLNSLI---SNNSKLtSHAITLQKTVEYITKLQQE 772
Cdd:smart00353   3 RERRRRRKINEAFDELRSLLptlPKNKKL-SKAEILRLAIEYIKSLQEE 50
bHLH_SF cd00083
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 728-771 2.57e-08

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


Pssm-ID: 381392 [Multi-domain]  Cd Length: 46  Bit Score: 50.60  E-value: 2.57e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 111955326 728 EQKRRFNIKMCFDMLNSLISNNSKLT--SHAITLQKTVEYITKLQQ 771
Cdd:cd00083    1 ERRRRDKINDAFEELKRLLPELPDSKklSKASILQKAVEYIRELQS 46
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 724-794 7.23e-08

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 50.62  E-value: 7.23e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 111955326 724 HISAEQKRRFNIKMCFDMLNSLI---SNNSKlTSHAITLQKTVEYITKLQQERGQMQEEARRLREEIEELNATI 794
Cdd:cd11400    5 HNVLERQRRNDLKNSFEKLRDLVpelADNEK-ASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRKKL 77
bHLH_ScINO2_like cd11388
basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and ...
 718-781 8.22e-08

basic helix-loop-helix (bHLH) domain found in Saccharomyces cerevisiae protein INO2 and similar proteins; INO2 is a positive regulatory factor required for depression of the co-regulated phospholipid biosynthetic enzymes in Saccharomyces cerevisiae. It is also involved in the expression of ITR1.


Pssm-ID: 381394  Cd Length: 68  Bit Score: 50.04  E-value: 8.22e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLI----SNNSKLTSHAITLQKTVEYITKLQQERGQMQEEAR 781
Cdd:cd11388    1 PVKKWKHVEAEKKRRNQIKKGFEDLINLInyprNNNEKRISKSELLNKAVDDIRGLLKANEQLQEEIN 68
PHA03247 PHA03247
large tegument protein UL36; Provisional
 294-715 3.28e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.56  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  294 PVAWPNPREIAHLGNADMIQPGlIPLQPNldfmDTFEPFQDLFSSSRSIFGSMLPASASAPVPDPNNPPAQESILP---T 370
Cdd:PHA03247 2569 PPPRPAPRPSEPAVTSRARRPD-APPQSA----RPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDphpP 2643

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  371 TALPTVSLPDSLIAPPTA-----------PSLAHMDEQGceHTSRTEDPFIQP-TDFGPSEPPLSVPQPFLPVFTmplls 438
Cdd:PHA03247 2644 PTVPPPERPRDDPAPGRVsrprrarrlgrAAQASSPPQR--PRRRAARPTVGSlTSLADPPPPPPTPEPAPHALV----- 2716

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  439 pSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQKFAGVNKAPSvithtasatlthdaPATTfsqsqglvITTHHPAPSA 518
Cdd:PHA03247 2717 -SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR--------------PPTT--------AGPPAPAPPA 2773

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  519 APCGlalspvtrPPQPRLTfvHPKPVSLTGGRPKQPHKIVPAPKPEPVS--LVLKNARIAPAAF-----SGQPQAVIMTS 591
Cdd:PHA03247 2774 APAA--------GPPRRLT--RPAVASLSESRESLPSPWDPADPPAAVLapAAALPPAASPAGPlppptSAQPTAPPPPP 2843

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  592 GPLKREGMLASTVSQSNVVIAPAAIARAPGVPEFHSSILVTDLghgtssPPAPVSRLFPSTAQDPLgkGEQVPLHGGSPQ 671
Cdd:PHA03247 2844 GPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRL------ARPAVSRSTESFALPPD--QPERPPQPQAPP 2915

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 111955326  672 VTVTGPSRDCPNSGQASPCASEQSPSPQSPQNNCSGKSDPKNVA 715
Cdd:PHA03247 2916 PPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959
bHLHzip_Mlx_like cd11404
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, ...
 719-792 6.19e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-like protein X (Mlx) family; Mlx, also termed Class D basic helix-loop-helix protein 13 (bHLHd13), or Max-like bHLHZip protein, or protein BigMax, or transcription factor-like protein 4, is a Max-like bHLHZip transcription regulator that interacts with the Max network of transcription factors. It forms a sequence-specific DNA-binding protein complex with some member of Mad family (Mad1 and Mad4) and Mondo family but not the Myc family and bind the E-box DNA to control transcription. The family also includes Saccharomyces cerevisiae INO4, which is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast.


Pssm-ID: 381410 [Multi-domain]  Cd Length: 70  Bit Score: 47.68  E-value: 6.19e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 111955326 719 NRQMkHISAEQKRRFNIKMCFDMLNSLI---SNNSklTSHAITLQKTVEYITKLqqergqmQEEARRLREEIEELNA 792
Cdd:cd11404    2 RRLN-HVRSEKKRRELIKKGYDELCALVpglDPQK--RTKADILQKAADWIQEL-------KEENEKLEEQLDELKE 68
bHLHzip_MGA_like cd19682
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) ...
 723-784 8.18e-07

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in MAX gene-associated protein (MGA) family; The MGA family includes MGA, Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins. MGA, also termed MAX dimerization protein 5 (MAD5), is a dual specificity T-box/ bHLHzip transcription factor that regulates the expression of both Max-network and T-box family target genes. It contains a Myc-like bHLHZip motif and requires heterodimerization with Max for binding to the preferred Myc-Max-binding site CACGTG. In addition to the bHLHZip domain, MGA harbors a second DNA-binding domain, the T-box or T-domain. It thus binds the preferred Brachyury-binding sequence and represses transcription of reporter genes containing promoter-proximal Brachyury-binding sites. spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381525 [Multi-domain]  Cd Length: 65  Bit Score: 46.88  E-value: 8.18e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 111955326 723 KHISAEQKRRFNIKMCFDMLNSLI-SNNSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLR 784
Cdd:cd19682    3 RHKKRERERRSELRELFDKLKQLLgLDSDEKASKLAVLTEAIEEIQQLKREEDELQKEKARLT 65
bHLH_scINO4_like cd11403
basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar ...
 724-794 1.84e-06

basic Helix-Loop-Helix (bHLH) domain found in Saccharomyces cerevisiae INO4 and similar proteins; INO4 is a bHLH transcriptional activator of phospholipid synthetic genes (such as INO1, CHO1/PSS, CHO2/PEM1, OPI3/PEM2, etc.). It is required for de-repression of phospholipid biosynthetic gene expression in response to inositol deprivation in yeast. INO4 dimerizes with INO2 and binds to an UAS DNA element to control expression of the genes whose expression is inositol-responsive.


Pssm-ID: 381409  Cd Length: 71  Bit Score: 46.30  E-value: 1.84e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 111955326 724 HISAEQKRRFNIKMCFDMLNSLIS--NNSKLTSHAITLQKTVEYITKLQQERgqmqeeaRRLREEIEELNATI 794
Cdd:cd11403    6 HISSEHKRREAIREGFDRLCAIVPalSSSQSRSEAVVYVKTVEYLKELYERR-------AKLRSQLRSKGVEI 71
bHLHzip_scCBP1 cd11398
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae ...
 716-792 2.17e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Saccharomyces cerevisiae centromere-binding protein 1 (CBP-1) and similar proteins; CBP-1, also termed centromere promoter factor 1 (CPF1), or centromere-binding factor 1 (CBF1), is a bHLHzip protein that is required for chromosome stability and methionine prototrophy. It binds as a homodimer to the centromere DNA elements I (CDEI, GTCACATG) region of the centromere that is required for optimal centromere function.


Pssm-ID: 381404 [Multi-domain]  Cd Length: 89  Bit Score: 46.56  E-value: 2.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 716 ALKNRQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERGQMQEEAR-------RLREEIE 788
Cdd:cd11398    3 WHRQRRDNHKEVERRRRENINEGINELAALVPGNAREKNKGAILARAVEYIQELQETEAKNIEKWTleklltdQAIAELA 82


                 ....
gi 111955326 789 ELNA 792
Cdd:cd11398   83 ALNE 86
bHLHzip_SREBP_like cd11395
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding ...
 718-787 8.90e-06

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in sterol regulatory element-binding protein (SREBP) family and similar proteins; The SREBP family includes SREBP1 and SREBP2, which are bHLHzip transcriptional activator of genes encoding proteins essential for cholesterol biosynthesis/uptake and fatty acid biosynthesis. SREBP1 and SREBP2 are principally found in the liver and in adipocytes and made up of an N-terminal transcription factor portion (composed of an activation domain, a bHLHzip domain, and a nuclear localization signal), a hydrophobic region containing two membrane spanning regions, and a C-terminal regulatory segment. They recognize a symmetric sterol regulatory element (TCACNCCAC) instead of E-box. The family also includes Saccharomyces cerevisiae transcription factor HMS1 (also termed high-copy MEP suppressor protein 1) and serine-rich protein TYE7. HMS1 is a putative bHLHzip transcription factor involved in exit from mitosis and pseudohyphal differentiation. TYE7, also termed basic-helix-loop-helix protein SGC1, is a putative bHLHzip transcription activator required for Ty1-mediated glycolytic gene expression. TYE7 N-terminal is extremely rich in serine residues. It binds DNA on E-box motifs, 5'-CANNTG-3'. TYE7 is not essential for growth.


Pssm-ID: 381401 [Multi-domain]  Cd Length: 87  Bit Score: 44.63  E-value: 8.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 718 KNRQMKHISAEQKRRFNIKMCFDMLNSLI---------SNNSKLT--------SHAITLQKTVEYITKLQQERGQMQEEA 780
Cdd:cd11395    1 PRKRLPHNAIEKRYRSNLNTKIERLRDAIpslrspegkSDDGGLGglapttklSKATILTKAIEYIRHLEQENERLEEEN 80


                 ....*..
gi 111955326 781 RRLREEI 787
Cdd:cd11395   81 EELRQQV 87
PHA03247 PHA03247
large tegument protein UL36; Provisional
 339-568 1.71e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 1.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  339 SRSIFGSMLPASASAPVPDPNNPPAQESILPTTALPTVSLPDSLIAPPTAPSLAhmdeqgcehTSRTEDPFIQPT----- 413
Cdd:PHA03247 2784 TRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPT---------APPPPPGPPPPSlplgg 2854

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  414 ------DF---GPSEPPLSVP--QPFLPVFTMPLLSPSPAPPPIspvlplvpppatALNPPAPPTFHQPQKfagvnKAPS 482
Cdd:PHA03247 2855 svapggDVrrrPPSRSPAAKPaaPARPPVRRLARPAVSRSTESF------------ALPPDQPERPPQPQA-----PPPP 2917

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  483 VITHTASATLTHDAPATTFSQSQGLVITTHHPAPSAAPCGLAlspvtrpPQPRLTFVHPKPVSLTGGRPKQPHKIVPAPK 562
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV-------PQPWLGALVPGRVAVPRFRVPQPAPSREAPA 2990


                  ....*.
gi 111955326  563 PEPVSL 568
Cdd:PHA03247 2991 SSTPPL 2996
bHLHzip_TFE3 cd18928
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and ...
 715-795 1.95e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor E3 (TFE3) and similar proteins; TFE3, also termed Class E basic helix-loop-helix protein 33 (bHLHe33), is a bHLHzip transcription factor that is involved in B cell function. It specifically recognizes and binds E-box sequences (5'-CANNTG-3'). Its efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF.


Pssm-ID: 381498 [Multi-domain]  Cd Length: 91  Bit Score: 43.88  E-value: 1.95e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 715 AALKNRQMK--HISAEQKRRFNIKMCFDMLNSLI--SNNSKLT-SHAITLQKTVEYITKLQQERGQMQEEARRLReEIEE 789
Cdd:cd18928    4 AFLKERQKKdnHNLIERRRRFNINDRIKELGTLIpkSTDPEMRwNKGTILKASVDYIRKLQKEQQRSKEIEMRQR-KLEQ 82


                 ....*.
gi 111955326 790 LNATII 795
Cdd:cd18928   83 ANRSLQ 88
bHLH_AtBIM_like cd11453
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like ...
 720-779 2.64e-05

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana BES1-interacting Myc-like proteins (BIMs) and similar proteins; The family includes Arabidopsis thaliana BIM1 and its homologs (BIM2 and BIM3), which are bHLH transcription factors that interact with BES1 to regulate transcription of Brassinosteroid (BR)-induced gene. BR regulates many growth and developmental processes such as cell elongation, vascular development, senescence stress responses, and photomorphogenesis. BIM1 heterodimerize with BES1 and bind to E-box sequences present in many BR-induced promoters to regulated BR-induced genes.


Pssm-ID: 381459  Cd Length: 77  Bit Score: 43.23  E-value: 2.64e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 720 RQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLqQERGQMQEE 779
Cdd:cd11453    3 PRSKHSATEQRRRSKINERLQALRDLIPHSDQKRDKASFLLEVIEYIQAL-QEKVAKLEE 61
bHLH_SOHLH_like cd19683
basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific ...
 718-776 3.62e-05

basic helix-loop-helix (bHLH) domain found in the spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein (SOHLH) family and similar proteins; The SOHLH family includes two bHLH transcription factors, SOHLH1 and SOHLH2. They are specifically in spermatogonia and oocytes and essential for early spermatogonial and oocyte differentiation. The family also includes transcription factor-like 5 protein (TCFL5) and similar proteins. TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381526  Cd Length: 58  Bit Score: 42.34  E-value: 3.62e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 111955326 718 KNRQmKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERGQM 776
Cdd:cd19683    1 KSRE-RHNAKERQRRERIKIACDQLRKLVPGCSRKTDKATVFEFTVAYIKFLREKLGDS 58
bHLHzip_MITF_like cd11397
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated ...
 718-778 5.24e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the microphthalmia-associated transcription factor family (MITF) family; The MITF (also known as microphthalmia-TFE, or MiT) family is a small family that contain a basic helix loop helix domain associated with a leucine zipper (bHLHZip). The MITF family comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF family can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381403  Cd Length: 69  Bit Score: 41.90  E-value: 5.24e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 111955326 718 KNRQMK--HISAEQKRRFNIKMCFDMLNSLISNNSK---LTSHAITLQKTVEYITKLQQERGQMQE 778
Cdd:cd11397    1 KDRQKKdnHNMIERRRRFNINDRIKELGTLLPKSNDpdmRWNKGTILKASVDYIRKLQKEQERLRQ 66
bHLHzip_Mnt cd11402
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar ...
 718-801 5.61e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins; Mnt, also termed Class D basic helix-loop-helix protein 3 (bHLHd3), or Myc antagonist MNT, or protein ROX, is a bHLHZip transcriptional repressor that binds DNA as a heterodimer with MAX. It binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'. Mnt has an important role as an antagonist and regulator of Myc activities and it is a potential tumor suppressor. Mnt is ubiquitously expressed. Mnt-deficient mice shown to exhibit early postnatal lethality.


Pssm-ID: 381408 [Multi-domain]  Cd Length: 77  Bit Score: 42.31  E-value: 5.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 718 KNRQMkHISAEQKRRFNIKMCFDMLNSLISN-NSKLTSHAITLQKTVEYITKLQQERGQMQEEARRLREEieelnatIIS 796
Cdd:cd11402    1 GTREV-HNKLEKNRRAHLKECFETLKRQIPNlDDKKTSNLNILRSALRYIQILKRKEKEYEHEMERLARE-------KIA 72


                 ....*
gi 111955326 797 CQQLL 801
Cdd:cd11402   73 LQQRL 77
bHLHzip_spESC1_like cd19690
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) ...
 724-784 9.91e-05

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Schizosaccharomyces pombe ESC1 (spESC1) and similar proteins; spESC1 is a bHLHzip protein with homology to human MyoD and Myf-5 myogenic differentiation inducers. It is involved in the sexual differentiation process.


Pssm-ID: 381533  Cd Length: 65  Bit Score: 41.29  E-value: 9.91e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 111955326 724 HISAEQKRRFNIKMCFDMLNSLI--SNNSKLTSHAItLQKTVEYITKLQQERGQMQEEARRLR 784
Cdd:cd19690    4 HKLAERKRRKEMKELFEDLRDALpqERGTKASKWEI-LTKAISYIQQLKRHIRELRSEVNDLR 65
bHLHzip_USF_MITF cd11387
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream ...
 724-772 2.51e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in USF/MITF family; The USF (upstream stimulatory factor)/MITF (microphthalmia-associated transcription factor) family includes two bHLHzip transcription factor subfamilies. USFs are ubiquitously expressed and key regulators of a wide number of gene regulation networks, including the stress and immune responses, cell cycle and proliferation, lipid and glucid metabolism. USFs recruit chromatin remodeling enzymes and interact with co-activators and the members of the transcription pre-initiation complex. USFs interact with high affinity to E-box regulatory elements. The MITF (also known as microphthalmia-TFE, or MiT) subfamily comprises four genes in mammals (MITF, TFE3, TFEB, and TFEC); each gene has different functions. MITF is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. TFEB is required for vascularization of the mouse placenta. TFE3 is involved in B cell function. TFEC regulates gene expression in macrophages. The MITF subfamily proteins can form homodimers or heterodimers with each other but not with other bHLH or bHLHzip proteins.


Pssm-ID: 381393 [Multi-domain]  Cd Length: 58  Bit Score: 39.93  E-value: 2.51e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 111955326 724 HISAEQKRRFNIKMCFDMLNSLISNNSKLT-----SHAITLQKTVEYITKLQQE 772
Cdd:cd11387    2 HNAVERRRRDNINEKIQELGSLVPPSRLETkdlkpNKGSILSKAVEYIRELQNQ 55
bHLHzip_Max cd11406
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, ...
 724-782 2.52e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in protein Max and similar proteins; Max, also termed Class D basic helix-loop-helix protein 4 (bHLHd4), or Myc-associated factor X, is a bHLHZip transcription regulator that forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a transcriptional repressor. Max homodimer bind DNA but is transcriptionally inactive. Targeted deletion of max results in early embryonic lethality in mice.


Pssm-ID: 381412  Cd Length: 69  Bit Score: 40.03  E-value: 2.52e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 111955326 724 HISAEQKRRFNIKMCFDML-NSLISNNSKLTSHAITLQKTVEYITKLQQ---ERGQMQEEARR 782
Cdd:cd11406    5 HNALERKRRDHIKDSFHSLrDSVPSLQGEKASRAQILKKATEYIQYMRRknhTHQQDIDDLKR 67
bHLH_AtbHLH_like cd11393
basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription ...
 724-771 7.34e-04

basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana genes coding transcription factors and similar proteins; bHLH proteins are the second largest class of plant transcription factors that regulate transcription of genes that are involve in many essential physiological and developmental process. bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. The Arabidopsis bHLH proteins that have been characterized so far have roles in regulation of fruit dehiscence, cell development (carpel, anther and epidermal), phytochrome signaling, flavonoid biosynthesis, hormone signaling and stress responses.


Pssm-ID: 381399 [Multi-domain]  Cd Length: 53  Bit Score: 38.32  E-value: 7.34e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 111955326 724 HISAEQKRRFNIKMCFDMLNSLISNNSKlTSHAITLQKTVEYITKLQQ 771
Cdd:cd11393    1 HSIAERKRREKINERIRALRSLVPNGGK-TDKASILDEAIEYIKFLQE 47
bHLHzip_TFAP4 cd11419
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and ...
 726-776 8.13e-04

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in transcription factor AP-4 (TFAP4) and similar proteins; TFAP4, also termed activating enhancer-binding protein 4, or Class C basic helix-loop-helix protein 41 (bHLHc41), is a bHLHzip transcription factor that activates both viral and cellular genes involved in the regulation of cellular proliferation, stemness, and epithelial-mesenchymal transition by binding to the symmetrical DNA sequence 5'-CAGCTG-3'.


Pssm-ID: 381425  Cd Length: 61  Bit Score: 38.45  E-value: 8.13e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 111955326 726 SAEQKRRFNIKMCFDMLNSLI--SNNSKLTSHAItLQKTVEYITKLQQERGQM 776
Cdd:cd11419   10 SNERRRMQSINAGFQSLRTLLphCDGEKLSKAAI-LQQTAEYIFSLEQEKTRL 61
bHLH_TCFL5 cd18909
basic helix-loop-helix (bHLH) domain found in transcription factor-like 5 protein (TCFL5) and ...
 720-774 8.62e-04

basic helix-loop-helix (bHLH) domain found in transcription factor-like 5 protein (TCFL5) and similar proteins; TCFL5, also termed Cha transcription factor, or HPV-16 E2-binding protein 1 (E2BP-1), is a bHLH transcription factor that plays a crucial role in spermatogenesis. It regulates cell proliferation or differentiation of cells through binding to a specific DNA sequence like other bHLH molecules.


Pssm-ID: 381479  Cd Length: 60  Bit Score: 38.38  E-value: 8.62e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 111955326 720 RQMKHISAEQKRRFNIKMCFDMLNSLISNNSKLTSHAITLQKTVEYITKLQQERG 774
Cdd:cd18909    2 RRERHNRMERDRRRRIRICCDELNLLVPFCNAETDKATTLQWTTAFLKYIQEKHG 56
PHA03247 PHA03247
large tegument protein UL36; Provisional
 348-711 9.75e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 9.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  348 PASASAPVPDPNNPPAQESILPTTalptvsLPDSLIAPPTAPSL---AHMDEQGCEHTSRTEDPFIQPTDFGPSE----- 419
Cdd:PHA03247 2496 PDPGGGGPPDPDAPPAPSRLAPAI------LPDEPVGEPVHPRMltwIRGLEELASDDAGDPPPPLPPAAPPAAPdrsvp 2569

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  420 PPLSVPQPFLPVFTMPLL---SPSPAPPPISPVLPLVPPPATALNPPAPPTFHQPQ--KFAGVNKAPSVITHTASATLTH 494
Cdd:PHA03247 2570 PPRPAPRPSEPAVTSRARrpdAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDppPPSPSPAANEPDPHPPPTVPPP 2649

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  495 DAP--------------ATTFSQSQGLVITTHHPAPSAAPCGLA-LSPVTRPPQPRLTfVHPKPVSLTGGRPKQP----- 554
Cdd:PHA03247 2650 ERPrddpapgrvsrprrARRLGRAAQASSPPQRPRRRAARPTVGsLTSLADPPPPPPT-PEPAPHALVSATPLPPgpaaa 2728

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  555 ------HKIVPAPKPEPVSLVL---KNARIAPAAFSGQPQAV---IMTSGP---LKREGMLASTVSQSNVVIAPAAIARA 619
Cdd:PHA03247 2729 rqaspaLPAAPAPPAVPAGPATpggPARPARPPTTAGPPAPAppaAPAAGPprrLTRPAVASLSESRESLPSPWDPADPP 2808

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326  620 PGVPEFHSSILVTDLGHGTSSPPAPVSRLFPSTAQDPLgkGEQVPLHGGspqVTVTGPSRDCPNSGQ--ASPCASEQSPS 697
Cdd:PHA03247 2809 AAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP--PPSLPLGGS---VAPGGDVRRRPPSRSpaAKPAAPARPPV 2883

                         410
                  ....*....|....
gi 111955326  698 PQSPQNNCSGKSDP 711
Cdd:PHA03247 2884 RRLARPAVSRSTES 2897
bHLHzip_MITF cd18926
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated ...
 715-795 1.19e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in microphthalmia-associated transcription factor (MITF) and similar proteins; MITF, also termed Class E basic helix-loop-helix protein 32 (bHLHe32), is a bHLHzip transcription factor that is involved in neural crest melanocytes development as well as the pigmented retinal epithelium. It regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. It binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR).


Pssm-ID: 381496  Cd Length: 104  Bit Score: 39.30  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111955326 715 AALKNRQMK--HISAEQKRRFNIKMCFDMLNSLI--SNNSKLT-SHAITLQKTVEYITKLQQERGQMQEEARRlREEIEE 789
Cdd:cd18926    6 ALAKERQKKdnHNLIERRRRFNINDRIKELGTLIpkSNDPDMRwNKGTILKASVDYIRKLQREQQRAKELENR-QKKLEH 84


                 ....*.
gi 111955326 790 LNATII 795
Cdd:cd18926   85 ANRHLL 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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