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Conserved domains on  [gi|111599734|gb|AAI17269|]
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Zinc finger protein 486 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-71 8.78e-31

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 8.78e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111599734    13 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-463 6.29e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 188 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 263
Cdd:COG5048   13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 264 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 309
Cdd:COG5048   92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 310 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 370
Cdd:COG5048  172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 371 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 441
Cdd:COG5048  252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                        330       340
                 ....*....|....*....|..
gi 111599734 442 AFNWSSDLNKHKRIHIGQKPRT 463
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAK 353
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-71 8.78e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 8.78e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111599734    13 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-53 6.57e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 6.57e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 111599734   15 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLG 53
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-52 2.10e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.10e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 111599734  15 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFL 52
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-463 6.29e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 188 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 263
Cdd:COG5048   13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 264 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 309
Cdd:COG5048   92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 310 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 370
Cdd:COG5048  172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 371 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 441
Cdd:COG5048  252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                        330       340
                 ....*....|....*....|..
gi 111599734 442 AFNWSSDLNKHKRIHIGQKPRT 463
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAK 353
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 3.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.75e-04
                          10        20
                  ....*....|....*....|....*
gi 111599734  337 LSKHEKIHTGEKPYKCEECGKAFTR 361
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
13-71 8.78e-31

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 113.07  E-value: 8.78e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 111599734    13 LQFRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLGIIVSKPDLITCLEQGIKP 71
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 15-53 6.57e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.21  E-value: 6.57e-21
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 111599734   15 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFLG 53
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 15-52 2.10e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.36  E-value: 2.10e-18
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 111599734  15 FRDVAVEFSLEEWHCLDTAQQNLYRDVMLENYRHLVFL 52
Cdd:cd07765    3 FEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
188-463 6.29e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 6.29e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 188 DKAFNQSSTHTtHKKIDTGEKPYKCEECGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFSSFTTHKKIHSGE-- 263
Cdd:COG5048   13 NSVLSSTPKST-LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNps 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 264 ---------------------------KPYICEECGKAFMYPYTLT--THKIIHTGEQPYK-----CKECDKAFNHPATL 309
Cdd:COG5048   92 dlnskslplsnskasssslsssssnsnDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPgnnssSVNTPQSNSLHPPL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 310 S---------------SHKKIHTGEKPYTCDKCGKAFISSSILSKHEKIHTGEKPYKCEECGKAF----TRSSHLTMHKI 370
Cdd:COG5048  172 PanslskdpssnlsllISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSS 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 371 IHTGEKPYKCEECG--KAFTWSAGLHKHRRTHTG-EKPYKCEECGKAYTTSSNLTEHK--TTHTGE--KPYKCKE--CGK 441
Cdd:COG5048  252 DSSSSASESPRSSLptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGK 331

                        330       340
                 ....*....|....*....|..
gi 111599734 442 AFNWSSDLNKHKRIHIGQKPRT 463
Cdd:COG5048  332 LFSRNDALKRHILLHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
320-457 2.45e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 2.45e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 320 KPYTCDKCGKAFISSSILSKH--EKIHTGE--KPYKCEE--CGKAFTRSSHLTMHKIIHTGEKPYKC--EECGKAFT--- 388
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSpll 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111599734 389 --WSAGLHKHRRTHTGEKPYKCE--ECGKAYTTSSNLTEHKTTHTGEKP--YKCKECGKAFNWSSDLNKHKRIHI 457
Cdd:COG5048  368 nnEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
189-341 7.77e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 7.77e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 189 KAFNQSSTHTTHK--KIDTGE--KPYKCEE--CGKAFNRSSHLTTHKITHTREKPYKC--EECGKVFKYFS-----SFTT 255
Cdd:COG5048  297 ISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQ 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 256 HKKIHSGEKPYICE--ECGKAFMYPYTLTTHKIIHTGEQPY--KCKECDKAFNHPATLSSHKKIHTGEKPYTCDKCGKAF 331
Cdd:COG5048  377 QYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFR 456

                        170
                 ....*....|
gi 111599734 332 ISSSILSKHE 341
Cdd:COG5048  457 RDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
192-385 3.23e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 192 NQSSTHTTHKKIDTGEKPYkceeCGKAFNRSSHLTTHKITHTR-EKPYKCEECGKVFKYFSSFTTHK--KIHSGE--KPY 266
Cdd:COG5048  247 SLSSSDSSSSASESPRSSL----PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPF 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 267 ICEE--CGKAFMYPYTLTTHKIIHTGEQPYKCK--ECDKAFN------HPATLSSHKKIHTGEKPYTCD-KCGKAFISSS 335
Cdd:COG5048  323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDS 402

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 111599734 336 ILSKHEKIHTGEKPY--KCEECGKAFTRSSHLTMHKIIHTGEKPYKCEECGK 385
Cdd:COG5048  403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 346-429 3.09e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.25  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 346 GEKPYKCE--ECGKAFTRSSHLTMHKiihtgekpyKCEECGKAFTWSAGLHKHRRTHTGEKPYKCEECGKAYTTSSNLTE 423
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 111599734 424 HKTTHT 429
Cdd:COG5189  417 HRKHSH 422
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 178-261 2.08e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 178 EKKPlkyiEGDKAFNQSSTHTTHKKIDT--------GEKPYKCE--ECGKAFNRSSHLTTHK-------ITH-------- 232
Cdd:COG5189  314 RKLP----CTNSSSNGKLAHGGERNIDTpsrmlkvkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqKLHenpspekm 389

                         90       100       110
                 ....*....|....*....|....*....|...
gi 111599734 233 ----TREKPYKCEECGKVFKYFSSFTTHKKiHS 261
Cdd:COG5189  390 nifsAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-361 3.75e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 3.75e-04
                          10        20
                  ....*....|....*....|....*
gi 111599734  337 LSKHEKIHTGEKPYKCEECGKAFTR 361
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
420-444 6.49e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.49e-04
                          10        20
                  ....*....|....*....|....*
gi 111599734  420 NLTEHKTTHTGEKPYKCKECGKAFN 444
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
364-388 1.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.02e-03
                          10        20
                  ....*....|....*....|....*
gi 111599734  364 HLTMHKIIHTGEKPYKCEECGKAFT 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 374-453 1.14e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 374 GEKPYKCE--ECGKAFTWSAGLHKHRrthtgekpyKCEECGKAYTTSSNLTEHKTTHTGEKPYKCKECGKAFNWSSDLNK 451
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111599734 452 HK 453
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-333 1.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.50e-03
                          10        20
                  ....*....|....*....|....*
gi 111599734  309 LSSHKKIHTGEKPYTCDKCGKAFIS 333
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
224-249 3.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.84e-03
                          10        20
                  ....*....|....*....|....*.
gi 111599734  224 HLTTHKITHTREKPYKCEECGKVFKY 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
395-417 4.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.11e-03
                          10        20
                  ....*....|....*....|...
gi 111599734  395 KHRRTHTGEKPYKCEECGKAYTT 417
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 290-369 4.42e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 111599734 290 GEQPYKCK--ECDKAFNHPATLSSHKKiHTGEKPYTCDKCGKafisssilSKHEKIHTGEKPYKCEECGKAFTRSSHLTM 367
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 111599734 368 HK 369
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
281-305 4.81e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.81e-03
                          10        20
                  ....*....|....*....|....*
gi 111599734  281 LTTHKIIHTGEQPYKCKECDKAFNH 305
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 210-232 9.44e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.43  E-value: 9.44e-03
                          10        20
                  ....*....|....*....|...
gi 111599734  210 YKCEECGKAFNRSSHLTTHKITH 232
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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