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Conserved domains on  [gi|1112968159|gb|APJ10070|]
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RpiR family transcriptional regulator [Bacillus safensis]

Protein Classification

MurR/RpiR family transcriptional regulator( domain architecture ID 11448252)

MurR/RpiR family transcriptional regulator similar to Escherichia coli MurR, which represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid

CATH:  1.10.10.10
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  15808743|8576032
SCOP:  4000148

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 5-243 1.16e-55

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


:

Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 179.35  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159   5 EIISSFNELESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESEQTPSLK----- 79
Cdd:COG1737    13 ARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERlrrls 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  80 ---STQHFLYEF-------IERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFP 149
Cdd:COG1737    93 pddSLEDILAKVleaeianLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGDGHL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 150 MNMQYLD---NSVTIVLSVSGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNIAYYVTDERVHRANITTQTPVV 226
Cdd:COG1737   173 QAESAALlgpGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVAQL 252

                         250
                  ....*....|....*..
gi 1112968159 227 YILEAMARDMFAMLKEK 243
Cdd:COG1737   253 ALIDALAAAVAQRDGDK 269
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 5-243 1.16e-55

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 179.35  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159   5 EIISSFNELESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESEQTPSLK----- 79
Cdd:COG1737    13 ARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERlrrls 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  80 ---STQHFLYEF-------IERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFP 149
Cdd:COG1737    93 pddSLEDILAKVleaeianLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGDGHL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 150 MNMQYLD---NSVTIVLSVSGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNIAYYVTDERVHRANITTQTPVV 226
Cdd:COG1737   173 QAESAALlgpGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVAQL 252

                         250
                  ....*....|....*..
gi 1112968159 227 YILEAMARDMFAMLKEK 243
Cdd:COG1737   253 ALIDALAAAVAQRDGDK 269
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 100-233 7.08e-32

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 113.86  E-value: 7.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 100 KIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFPMNMQYL--DNSVTIVLSVSGENSITIDHIS 177
Cdd:cd05013     2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANltPGDVVIAISFSGETKETVEAAE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1112968159 178 KLKREGSKIISITNNQHCTISRISDLNIAYYVTDERVHRANITTQTPVVYILEAMA 233
Cdd:cd05013    82 IAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALF 137
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 107-240 6.29e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 66.55  E-value: 6.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 107 LIAEAKNVLFIGTGSSGILAQYGARYFSSLEK--FSFYINDPFFPMNMQYLD-NSVTIVLSVSGENSITIDHISKLKREG 183
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYkvVEVELASELRHGVLALVDeDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1112968159 184 SKIISITNNQHCTISRISDLNIaYYVTDERVHRANITTqtpvvYILEAMARDMFAML 240
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVL-YINAGPETGVASTKS-----ITAQLAALDALAVA 131
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
33-203 6.21e-11

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 61.86  E-value: 6.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  33 IRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLeSEQTPSLKSTQH-------FLYEFIERTLKG--------DF 97
Cdd:PRK14101  377 IVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGL-TGTIPMSHSQVHlgdtatdFGAKVLDNTVSAilqlrehlNF 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  98 EgKIKEAAKLIAEAKNVLFIGTGSSGILAQyGARYfssleKFsFYINDPFFPMNMQYLDNS---------VTIVLSVSGE 168
Cdd:PRK14101  456 E-HVEQAIDILNNARRIEFYGLGNSNIVAQ-DAHY-----KF-FRFGIPTIAYGDLYMQAAsaallgkgdVIVAVSKSGR 527

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1112968159 169 NSITIDHISKLKREGSKIISITnNQHCTISRISDL 203
Cdd:PRK14101  528 APELLRVLDVAMQAGAKVIAIT-SSNTPLAKRATV 561
 
Name Accession Description Interval E-value
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 5-243 1.16e-55

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 179.35  E-value: 1.16e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159   5 EIISSFNELESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESEQTPSLK----- 79
Cdd:COG1737    13 ARYPSLSPSERRIADYILDNPEEVAFMSIAELAEAAGVSEATVVRFCRKLGFSGFPELKLALAQELAEGLSSYERlrrls 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  80 ---STQHFLYEF-------IERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFP 149
Cdd:COG1737    93 pddSLEDILAKVleaeianLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGDGHL 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 150 MNMQYLD---NSVTIVLSVSGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNIAYYVTDERVHRANITTQTPVV 226
Cdd:COG1737   173 QAESAALlgpGDVVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSSAFSSRVAQL 252

                         250
                  ....*....|....*..
gi 1112968159 227 YILEAMARDMFAMLKEK 243
Cdd:COG1737   253 ALIDALAAAVAQRDGDK 269
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 100-233 7.08e-32

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 113.86  E-value: 7.08e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 100 KIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFPMNMQYL--DNSVTIVLSVSGENSITIDHIS 177
Cdd:cd05013     2 ALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQLMSAANltPGDVVIAISFSGETKETVEAAE 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1112968159 178 KLKREGSKIISITNNQHCTISRISDLNIAYYVTDERVHRANITTQTPVVYILEAMA 233
Cdd:cd05013    82 IAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSSAFSSRIAQLALIDALF 137
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 107-240 6.29e-14

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 66.55  E-value: 6.29e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 107 LIAEAKNVLFIGTGSSGILAQYGARYFSSLEK--FSFYINDPFFPMNMQYLD-NSVTIVLSVSGENSITIDHISKLKREG 183
Cdd:pfam01380   1 LLAKAKRIFVIGRGTSYAIALELALKFEEIGYkvVEVELASELRHGVLALVDeDDLVIAISYSGETKDLLAAAELAKARG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1112968159 184 SKIISITNNQHCTISRISDLNIaYYVTDERVHRANITTqtpvvYILEAMARDMFAML 240
Cdd:pfam01380  81 AKIIAITDSPGSPLAREADHVL-YINAGPETGVASTKS-----ITAQLAALDALAVA 131
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
33-203 6.21e-11

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 61.86  E-value: 6.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  33 IRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLeSEQTPSLKSTQH-------FLYEFIERTLKG--------DF 97
Cdd:PRK14101  377 IVDIARKADVSQPTVIRFCRSLGCQGLSDFKLKLATGL-TGTIPMSHSQVHlgdtatdFGAKVLDNTVSAilqlrehlNF 455

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  98 EgKIKEAAKLIAEAKNVLFIGTGSSGILAQyGARYfssleKFsFYINDPFFPMNMQYLDNS---------VTIVLSVSGE 168
Cdd:PRK14101  456 E-HVEQAIDILNNARRIEFYGLGNSNIVAQ-DAHY-----KF-FRFGIPTIAYGDLYMQAAsaallgkgdVIVAVSKSGR 527

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1112968159 169 NSITIDHISKLKREGSKIISITnNQHCTISRISDL 203
Cdd:PRK14101  528 APELLRVLDVAMQAGAKVIAIT-SSNTPLAKRATV 561
PRK11337 PRK11337
MurR/RpiR family transcriptional regulator;
33-202 7.47e-11

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183089 [Multi-domain]  Cd Length: 292  Bit Score: 60.93  E-value: 7.47e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  33 IRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESEQT------PSLKSTQHFLYEFIERTLKGDFEGK------ 100
Cdd:PRK11337   49 LKDIAEALAVSEAMIVKVAKKLGFSGFRNLRSALEDYFSQSEQvlhselSFDDAPQDVVNKVFNTSLQAIEETQsildvd 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 101 -IKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFPMNMQYL--DNSVTIVLSVSGENSITIDHIS 177
Cdd:PRK11337  129 eFHRAARFFYQARQRDLYGAGGSAAIARDVQHKFLRIGVRCQAYDDAHIMLMSAALlqEGDVVLVVSHSGRTSDVIEAVE 208

                         170       180
                  ....*....|....*....|....*
gi 1112968159 178 KLKREGSKIISITNNQHCTISRISD 202
Cdd:PRK11337  209 LAKKNGAKIICITNSYHSPIAKLAD 233
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 114-212 2.62e-10

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 56.40  E-value: 2.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 114 VLFIGTGSSGILAQYGARYFSSLEKFSFYINdpffPMNM------QYLDNSVTIVLSVSGENSITIDHISKLKREGSKII 187
Cdd:cd05014     3 VVVTGVGKSGHIARKIAATLSSTGTPAFFLH----PTEAlhgdlgMVTPGDVVIAISNSGETDELLNLLPHLKRRGAPII 78

                          90       100
                  ....*....|....*....|....*
gi 1112968159 188 SITNNQHCTISRISDLNIAYYVTDE 212
Cdd:cd05014    79 AITGNPNSTLAKLSDVVLDLPVEEE 103
HTH_6 pfam01418
Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best ...
 8-73 9.79e-10

Helix-turn-helix domain, rpiR family; This domain contains a helix-turn-helix motif. The best characterized member of this family is Swiss:P39266. RpiR is a regulator of the expression of rpiB gene.


Pssm-ID: 334531 [Multi-domain]  Cd Length: 77  Bit Score: 53.49  E-value: 9.79e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1112968159   8 SSFNELESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESE 73
Cdd:pfam01418  12 SKLTKSERKIADYILAHPDLAIHLSISAIAKAAGVSEATIVRFCQKLGFSGFPELKLALAGELANS 77
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 113-205 1.13e-09

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 54.81  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 113 NVLFIGTGSSGILAQYGARYFSSLEKF-------SFYINDPFFPmnmqyLDNSVTIVLSVSGENSITIDHISKLKREGSK 185
Cdd:cd05008     1 RILIVGCGTSYHAALVAKYLLERLAGIpveveaaSEFRYRRPLL-----DEDTLVIAISQSGETADTLAALRLAKEKGAK 75

                          90       100
                  ....*....|....*....|
gi 1112968159 186 IISITNNQHCTISRISDLNI 205
Cdd:cd05008    76 TVAITNVVGSTLAREADYVL 95
GlmS COG0449
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ...
 89-203 1.13e-07

Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440218 [Multi-domain]  Cd Length: 610  Bit Score: 51.94  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  89 IERTLKG--DFEGKIK-----EAAKLIAEAKNVLFIGTGSS---GILAQYgarYFSSLEKFS--------FYINDPFFPm 150
Cdd:COG0449   265 IRDTLRGrlDEDGRVVldelnLAAEDLRNIDRIYIVACGTSyhaGLVGKY---LIEELARIPveveiaseFRYRDPVVD- 340

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1112968159 151 nmqylDNSVTIVLSVSGEnsiTIDHISKL---KREGSKIISITNNQHCTISRISDL 203
Cdd:COG0449   341 -----PGTLVIAISQSGE---TADTLAALreaKEKGAKVLAICNVVGSTIARESDA 388
PRK00331 PRK00331
isomerizing glutamine--fructose-6-phosphate transaminase;
89-203 1.37e-07

isomerizing glutamine--fructose-6-phosphate transaminase;


Pssm-ID: 234729 [Multi-domain]  Cd Length: 604  Bit Score: 51.58  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  89 IERTLKG--DFEGKIKEAAKLIAEAKNVLFIGTGSS---GILAqygaRYFssLEKFS-----------FYINDPffPMNm 152
Cdd:PRK00331  265 IRDTLEGrlDELGEGELADEDLKKIDRIYIVACGTSyhaGLVA----KYL--IESLAgipveveiaseFRYRDP--VLS- 335

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1112968159 153 qylDNSVTIVLSVSGEnsiTIDHISKL---KREGSKIISITNNQHCTISRISDL 203
Cdd:PRK00331  336 ---PKTLVIAISQSGE---TADTLAALrlaKELGAKTLAICNVPGSTIARESDA 383
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 87-203 1.63e-07

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 49.88  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  87 EFIERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFPmnmQYLDNSVTIVLSVS 166
Cdd:cd05005     9 EEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTP---AIGPGDLLIAISGS 85

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1112968159 167 GENSITIDHISKLKREGSKIISITNNQHCTISRISDL 203
Cdd:cd05005    86 GETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADV 122
PRK11302 PRK11302
DNA-binding transcriptional regulator HexR; Provisional
 7-198 1.68e-07

DNA-binding transcriptional regulator HexR; Provisional


Pssm-ID: 183082 [Multi-domain]  Cd Length: 284  Bit Score: 50.76  E-value: 1.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159   7 ISSFNELESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYL-----------ESEQT 75
Cdd:PRK11302   11 LEHLSKSERKVAEVILASPQTAIHSSIATLAKMANVSEPTVNRFCRSLDTKGFPDFKLHLAQSLangtpyvnrnvEEDDS 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  76 PSLKSTQHFLYEF--IERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQygaryfSSLEKFsFYINDP---FFPM 150
Cdd:PRK11302   91 VEAYTGKIFESAMasLDHARQSLDPSAINRAVDLLTQAKKISFFGLGASAAVAH------DAQNKF-FRFNVPvvyFDDI 163

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 151 NMQYL------DNSVTIVLSVSGENSITIDhISKLKRE-GSKIISITNN-----QHCTIS 198
Cdd:PRK11302  164 VMQRMscmnssDGDVVVLISHTGRTKSLVE-LAQLAREnGATVIAITSAgsplaREATLA 222
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 87-213 8.64e-07

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 48.74  E-value: 8.64e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  87 EFIERTLKGdFEGKIKEAAKLIAEAKN--VLFIGTGSSGILAQYGARYFSSLEKF---SFYINDpfFPMNMQYLDNSVTI 161
Cdd:COG2222     9 EAWRRALAA-LAAAIAALLARLRAKPPrrVVLVGAGSSDHAAQAAAYLLERLLGIpvaALAPSE--LVVYPAYLKLEGTL 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1112968159 162 VLSV--SGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNIAYYVTDER 213
Cdd:COG2222    86 VVAIsrSGNSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVLPLPAGPEK 139
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 89-212 1.93e-06

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 47.66  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  89 IERTLKGDFEgkikEAAKLIAEAKN-VLFIGTGSSGILAQYGARYFSSLEKFSFYI---------------NDpffpmnm 152
Cdd:COG0794    25 LAERLDESFE----KAVELILNCKGrVVVTGMGKSGHIARKIAATLASTGTPAFFLhpaeashgdlgmitpGD------- 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 153 qyldnsVTIVLSVSGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNIAYYVTDE 212
Cdd:COG0794    94 ------VVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDLPVERE 147
PRK11557 PRK11557
MurR/RpiR family transcriptional regulator;
14-127 2.55e-06

MurR/RpiR family transcriptional regulator;


Pssm-ID: 183195 [Multi-domain]  Cd Length: 278  Bit Score: 47.45  E-value: 2.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  14 ESALYRYIMENSEKVVYMRIRDLADAAHISTSSVLRFCRKVNCEGFSEFKVKLKMYLESEQTPSLKSTQH---------- 83
Cdd:PRK11557   14 DRKLADYLLLQPDTARHLSSQQLANEAGVSQSSVVKFAQKLGYKGFPALKLALSEALASQPEPPSVPVHNqirgddplrl 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1112968159  84 ----FLYE---FIERTLKGDFEGKIKEAAKLIAEAKNVLFIGTGSSGILAQ 127
Cdd:PRK11557   94 vgekLIKEntaAMRATLDVNSEEKLHECVTMLRSARRIILTGIGASGLVAQ 144
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 114-190 2.82e-05

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 41.59  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 114 VLFIGTGSSGILAQYGARYFSSLEKF-SFYINDPFFPMNMQYL---DNSVTIVLSVSGENSITIDHISKLKREGSKIISI 189
Cdd:cd04795     1 IFVIGIGGSGAIAAYFALELLELTGIeVVALIATELEHASLLSllrKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                  .
gi 1112968159 190 T 190
Cdd:cd04795    81 T 81
PTZ00295 PTZ00295
glucosamine-fructose-6-phosphate aminotransferase; Provisional
 99-205 8.01e-05

glucosamine-fructose-6-phosphate aminotransferase; Provisional


Pssm-ID: 240349 [Multi-domain]  Cd Length: 640  Bit Score: 43.47  E-value: 8.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  99 GKIKEAAKLIAEAKNVLFIGTGSSGILAQYGARYFSSLEKF-SFYINDPFFPMNMQYLDNSVT-IVLSVSGENSITIDHI 176
Cdd:PTZ00295  310 GGLDQYLEELLNIKNLILVGCGTSYYAALFAASIMQKLKCFnTVQVIDASELTLYRLPDEDAGvIFISQSGETLDVVRAL 389

                          90       100
                  ....*....|....*....|....*....
gi 1112968159 177 SKLKREGSKIISITNNQHCTISRISDLNI 205
Cdd:PTZ00295  390 NLADELNLPKISVVNTVGSLIARSTDCGV 418
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 113-192 1.46e-04

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 40.33  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159 113 NVLFIGTGSSGILAQYGARYFSSLEKFSFYINDPFFPMNmqYLD-NSVTIVLSVSGENSITIDHISKLKREGSKIISITN 191
Cdd:cd05017     1 NIVILGMGGSGIGGDLLESLLLDEAKIPVYVVKDYTLPA--FVDrKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAITS 78


                  .
gi 1112968159 192 N 192
Cdd:cd05017    79 G 79
PTZ00394 PTZ00394
glucosamine-fructose-6-phosphate aminotransferase; Provisional
 73-205 3.15e-03

glucosamine-fructose-6-phosphate aminotransferase; Provisional


Pssm-ID: 173585 [Multi-domain]  Cd Length: 670  Bit Score: 38.32  E-value: 3.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1112968159  73 EQTPSLKSTQHFLYEFIERTLKgdFEGKIKEAAKLIAEAKNVLFIGTGSSgILAQYGAR-YFSSLEKFSFYI-NDP-FFP 149
Cdd:PTZ00394  318 EQPESVISSMHGRIDFSSGTVQ--LSGFTQQSIRAILTSRRILFIACGTS-LNSCLAVRpLFEELVPLPISVeNASdFLD 394

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1112968159 150 MNMQYLDNSVTIVLSVSGENSITIDHISKLKREGSKIISITNNQHCTISRISDLNI 205
Cdd:PTZ00394  395 RRPRIQRDDVCFFVSQSGETADTLMALQLCKEAGAMCVGITNVVGSSISRLTHYAI 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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