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Conserved domains on  [gi|1110581546|emb|SHM40309|]
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hypothetical protein SAMN05443668_101498 [Cryptosporangium aurantiacum]

Protein Classification

alpha/beta hydrolase family protein( domain architecture ID 10790586)

alpha/beta hydrolase family protein catalyzes the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad

CATH:  3.40.50.1820
EC:  3.-.-.-
Gene Ontology:  GO:0016787
PubMed:  19508187|12369917|37582413

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
55-247 5.97e-23

Predicted dienelactone hydrolase [General function prediction only];


:

Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 96.33  E-value: 5.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  55 ASIEAATGPFAVGTQPIVGASGFGGGQ----IYYPTDTSQTYGA------VVIVPGFISVWAQLNWLGPRLASQGFVVIG 124
Cdd:COG4188    15 ASPLRQPGPFAVGVQTLTLRDPSRDRPlpvdVWYPATAPADAPAggpfplVVLSHGLGGSREGYAYLAEHLASHGYVVAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 125 IE-----TSVITDLPDPRGDQAL------------AALD----WATTRSPVASRIDRTRLAAAGWSMGG------GGLR- 176
Cdd:COG4188    95 PDhpgsnAADLSAALDGLADALDpeelwerpldlsFVLDqllaLNKSDPPLAGRLDLDRIGVIGHSLGGytalalAGARl 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 177 -------------------------RAALQRPSLKAIVGMAPWN----GERNWSAVTVPTLFFGGSSDAVASPNDHAKPF 227
Cdd:COG4188   175 dfaalrqycgknpdlqcraldlprlAYDLRDPRIKAVVALAPGGsglfGEEGLAAITIPVLLVAGSADDVTPAPDEQIRP 254

                         250       260
                  ....*....|....*....|
gi 1110581546 228 YNSITRAEKDYIELRNADHF 247
Cdd:COG4188   255 FDLLPGADKYLLTLEGATHF 274
 
Name Accession Description Interval E-value
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
55-247 5.97e-23

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 96.33  E-value: 5.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  55 ASIEAATGPFAVGTQPIVGASGFGGGQ----IYYPTDTSQTYGA------VVIVPGFISVWAQLNWLGPRLASQGFVVIG 124
Cdd:COG4188    15 ASPLRQPGPFAVGVQTLTLRDPSRDRPlpvdVWYPATAPADAPAggpfplVVLSHGLGGSREGYAYLAEHLASHGYVVAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 125 IE-----TSVITDLPDPRGDQAL------------AALD----WATTRSPVASRIDRTRLAAAGWSMGG------GGLR- 176
Cdd:COG4188    95 PDhpgsnAADLSAALDGLADALDpeelwerpldlsFVLDqllaLNKSDPPLAGRLDLDRIGVIGHSLGGytalalAGARl 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 177 -------------------------RAALQRPSLKAIVGMAPWN----GERNWSAVTVPTLFFGGSSDAVASPNDHAKPF 227
Cdd:COG4188   175 dfaalrqycgknpdlqcraldlprlAYDLRDPRIKAVVALAPGGsglfGEEGLAAITIPVLLVAGSADDVTPAPDEQIRP 254

                         250       260
                  ....*....|....*....|
gi 1110581546 228 YNSITRAEKDYIELRNADHF 247
Cdd:COG4188   255 FDLLPGADKYLLTLEGATHF 274
 
Name Accession Description Interval E-value
COG4188 COG4188
Predicted dienelactone hydrolase [General function prediction only];
55-247 5.97e-23

Predicted dienelactone hydrolase [General function prediction only];


Pssm-ID: 443342 [Multi-domain]  Cd Length: 326  Bit Score: 96.33  E-value: 5.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  55 ASIEAATGPFAVGTQPIVGASGFGGGQ----IYYPTDTSQTYGA------VVIVPGFISVWAQLNWLGPRLASQGFVVIG 124
Cdd:COG4188    15 ASPLRQPGPFAVGVQTLTLRDPSRDRPlpvdVWYPATAPADAPAggpfplVVLSHGLGGSREGYAYLAEHLASHGYVVAA 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 125 IE-----TSVITDLPDPRGDQAL------------AALD----WATTRSPVASRIDRTRLAAAGWSMGG------GGLR- 176
Cdd:COG4188    95 PDhpgsnAADLSAALDGLADALDpeelwerpldlsFVLDqllaLNKSDPPLAGRLDLDRIGVIGHSLGGytalalAGARl 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 177 -------------------------RAALQRPSLKAIVGMAPWN----GERNWSAVTVPTLFFGGSSDAVASPNDHAKPF 227
Cdd:COG4188   175 dfaalrqycgknpdlqcraldlprlAYDLRDPRIKAVVALAPGGsglfGEEGLAAITIPVLLVAGSADDVTPAPDEQIRP 254

                         250       260
                  ....*....|....*....|
gi 1110581546 228 YNSITRAEKDYIELRNADHF 247
Cdd:COG4188   255 FDLLPGADKYLLTLEGATHF 274
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
80-248 8.11e-18

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 80.40  E-value: 8.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  80 GQIYYPtDTSQTYGAVVIVPGFISVWAQLNWLGPRLASQGFVVIGIET--------------SVITDLPDPRGDQ-ALAA 144
Cdd:COG0412    18 GYLARP-AGGGPRPGVVVLHEIFGLNPHIRDVARRLAAAGYVVLAPDLygrggpgddpdearALMGALDPELLAAdLRAA 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 145 LDWATTRspvaSRIDRTRLAAAGWSMGGGGLRRAALQRPSLKAIVGMAPW----NGERNWSAVTVPTLFFGGSSDAVASP 220
Cdd:COG0412    97 LDWLKAQ----PEVDAGRVGVVGFCFGGGLALLAAARGPDLAAAVSFYGGlpadDLLDLAARIKAPVLLLYGEKDPLVPP 172

                         170       180       190
                  ....*....|....*....|....*....|
gi 1110581546 221 NDHAKpFYNSITRAEKDY--IELRNADHFF 248
Cdd:COG0412   173 EQVAA-LEAALAAAGVDVelHVYPGAGHGF 201
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
80-268 3.97e-16

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 75.82  E-value: 3.97e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  80 GQIYYPTDtSQTYGAVVIVPGF-ISVWAQLNWLGPRLASQGFVVIgietsvitdLPDPRG-------------DQALAAL 145
Cdd:COG1506    12 GWLYLPAD-GKKYPVVVYVHGGpGSRDDSFLPLAQALASRGYAVL---------APDYRGygesagdwggdevDDVLAAI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 146 DWATTRSpvasRIDRTRLAAAGWSMGGGGLRRAALQRPSL-KAIVGMA----------------------PWNGERNWSA 202
Cdd:COG1506    82 DYLAARP----YVDPDRIGIYGHSYGGYMALLAAARHPDRfKAAVALAgvsdlrsyygttreyterlmggPWEDPEAYAA 157

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1110581546 203 ---------VTVPTLFFGGSSDAVASPnDHAKPFYNSITRA--EKDYIELRNADHFFPTSANTTMAKYFISWLKRWV 268
Cdd:COG1506   158 rsplayadkLKTPLLLIHGEADDRVPP-EQAERLYEALKKAgkPVELLVYPGEGHGFSGAGAPDYLERILDFLDRHL 233
PldB COG2267
Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];
80-266 1.36e-14

Lysophospholipase, alpha-beta hydrolase superfamily [Lipid transport and metabolism];


Pssm-ID: 441868 [Multi-domain]  Cd Length: 221  Bit Score: 71.19  E-value: 1.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  80 GQIYYPTDTSQtyGAVVIVPGFISVWAQLNWLGPRLASQGFVVIGI----------ETSVITDLPDPRGDqALAALDWAT 149
Cdd:COG2267    18 GRRWRPAGSPR--GTVVLVHGLGEHSGRYAELAEALAAAGYAVLAFdlrghgrsdgPRGHVDSFDDYVDD-LRAALDALR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 150 TRSPvasridrTRLAAAGWSMGGGGLRRAALQRPS-LKAIVGMAPWNGE-----------------RNWSAVTVPTLFFG 211
Cdd:COG2267    95 ARPG-------LPVVLLGHSMGGLIALLYAARYPDrVAGLVLLAPAYRAdpllgpsarwlralrlaEALARIDVPVLVLH 167

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1110581546 212 GSSDAVAsPNDHAKPFYNSITrAEKDYIELRNADHFFPTSAN-TTMAKYFISWLKR 266
Cdd:COG2267   168 GGADRVV-PPEAARRLAARLS-PDVELVLLPGARHELLNEPArEEVLAAILAWLER 221
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 80-247 4.16e-13

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 67.63  E-value: 4.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  80 GQIYYPTDTSQTYGAVVIVPGFISVWAQLNWLGPRLASQGFVVIgietsvitdLPDPRG-----------------DqAL 142
Cdd:COG1073    25 GDLYLPAGASKKYPAVVVAHGNGGVKEQRALYAQRLAELGFNVL---------AFDYRGygesegepreegsperrD-AR 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 143 AALDWATTRSPVasriDRTRLAAAGWSMGGGGLRRAALQRPSLKAIVGMAPWN--------------------------- 195
Cdd:COG1073    95 AAVDYLRTLPGV----DPERIGLLGISLGGGYALNAAATDPRVKAVILDSPFTsledlaaqrakeargaylpgvpylpnv 170

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1110581546 196 -----GERNWSA------VTVPTLFFGGSSDAVASPnDHAKPFYNSiTRAEKDYIELRNADHF 247
Cdd:COG1073   171 rlaslLNDEFDPlakiekISRPLLFIHGEKDEAVPF-YMSEDLYEA-AAEPKELLIVPGAGHV 231
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
82-269 1.03e-08

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 54.11  E-value: 1.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  82 IYYPTDTSQTYGAVVIVPG--FIS-VWAQLNWLGPRLASQ-GFVVIGIETSVITDLPDPRG-DQALAALDWATTRSPvAS 156
Cdd:COG0657     3 VYRPAGAKGPLPVVVYFHGggWVSgSKDTHDPLARRLAARaGAAVVSVDYRLAPEHPFPAAlEDAYAALRWLRANAA-EL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 157 RIDRTRLAAAGWSMGGG-----GLRRAALQRPSLKAIVGMAPW-----NGERNWSAVTVPTLFFGGSSDAVAspnDHAKP 226
Cdd:COG0657    82 GIDPDRIAVAGDSAGGHlaaalALRARDRGGPRPAAQVLIYPVldltaSPLRADLAGLPPTLIVTGEADPLV---DESEA 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1110581546 227 FYNSITRA--EKDYIELRNADHFFPTSANTTMAKYFISWLKRWVD 269
Cdd:COG0657   159 LAAALRAAgvPVELHVYPGGGHGFGLLAGLPEARAALAEIAAFLR 203
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 78-266 5.58e-08

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 52.31  E-value: 5.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  78 GGGQIYYptdtsQTYG----AVVIVPGFISVWAQLNWLGPRLAsQGFVVIGIetsvitDLP------DPRGDQALAAL-- 145
Cdd:COG0596    10 DGVRLHY-----REAGpdgpPVVLLHGLPGSSYEWRPLIPALA-AGYRVIAP------DLRghgrsdKPAGGYTLDDLad 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 146 DWATtrspVASRIDRTRLAAAGWSMGGGGLRRAALQRPS-LKAIV----------------------------GMAPWNG 196
Cdd:COG0596    78 DLAA----LLDALGLERVVLVGHSMGGMVALELAARHPErVAGLVlvdevlaalaeplrrpglapealaallrALARTDL 153

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 197 ERNWSAVTVPTLFFGGSSDAVASPnDHAKPFYNSITRAEkdYIELRNADHFFPTSANTTMAKYFISWLKR 266
Cdd:COG0596   154 RERLARITVPTLVIWGEKDPIVPP-ALARRLAELLPNAE--LVVLPGAGHFPPLEQPEAFAAALRDFLAR 220
COG4099 COG4099
Predicted peptidase [General function prediction only];
139-264 9.48e-08

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 51.89  E-value: 9.48e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 139 DQALAALDWATTRSpvasRIDRTRLAAAGWSMGGGGLRRAALQRPSL-KAIVGMAPWNGERNWSAV-TVPTLFFGGSSDA 216
Cdd:COG4099   107 DAVLALLDDLIAEY----RIDPDRIYLTGLSMGGYGTWDLAARYPDLfAAAVPICGGGDPANAANLkKVPVWIFHGAKDD 182

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1110581546 217 VASPnDHAKPFYNSITR--AEKDYIELRNADHFFPTSANTTMAkyFISWL 264
Cdd:COG4099   183 VVPV-EESRAMVEALKAagADVKYTEYPGVGHNSWDPAYANPD--LYDWL 229
COG2945 COG2945
Alpha/beta superfamily hydrolase [General function prediction only];
141-248 4.00e-05

Alpha/beta superfamily hydrolase [General function prediction only];


Pssm-ID: 442188 [Multi-domain]  Cd Length: 201  Bit Score: 43.61  E-value: 4.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 141 ALAALDWATTRSPvasridrTRLAAAGWSMGGG-GLrRAALQRPSLKAIVGMAP---WNGERNWSAVTVPTLFFGGSSDA 216
Cdd:COG2945    83 AAAALDWLRAQNP-------LPLWLAGFSFGAYvAL-QLAMRLPEVEGLILVAPpvnRYDFSFLAPCPAPTLVIHGEQDE 154

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1110581546 217 VASPnDHAKPFYNSItRAEKDYIELRNADHFF 248
Cdd:COG2945   155 VVPP-AEVLDWARPL-SPPLPVVVVPGADHFF 184
YvaK COG1647
Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];
94-266 9.52e-05

Esterase/lipase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 441253 [Multi-domain]  Cd Length: 246  Bit Score: 43.01  E-value: 9.52e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  94 AVVIVPGFISVWAQLNWLGPRLASQGFVVIGIetsvitDLP----DPRG----------DQALAALDWATTRSPvasrid 159
Cdd:COG1647    17 GVLLLHGFTGSPAEMRPLAEALAKAGYTVYAP------RLPghgtSPEDllkttwedwlEDVEEAYEILKAGYD------ 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 160 rtRLAAAGWSMGGG-GLRrAALQRPSLKAIVGMAP------WNG------------------------------------ 196
Cdd:COG1647    85 --KVIVIGLSMGGLlALL-LAARYPDVAGLVLLSPalkiddPSApllpllkylarslrgigsdiedpevaeyaydrtplr 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546 197 ------------ERNWSAVTVPTLFFGGSSDAVASPnDHAKPFYNSITRAEKDYIELRNADHFFPTSANT-TMAKYFISW 263
Cdd:COG1647   162 alaelqrlirevRRDLPKITAPTLIIQSRKDEVVPP-ESARYIYERLGSPDKELVWLEDSGHVITLDKDReEVAEEILDF 240


                  ...
gi 1110581546 264 LKR 266
Cdd:COG1647   241 LER 243
EstA COG1075
Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and ...
 95-193 9.48e-03

Triacylglycerol esterase/lipase EstA, alpha/beta hydrolase fold [Lipid transport and metabolism];


Pssm-ID: 440693 [Multi-domain]  Cd Length: 106  Bit Score: 35.19  E-value: 9.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110581546  95 VVIVPGFISVWAQLNWLGPRLASQGFVVIGIE-TSVITDLPDpRGDQALAALDWATTRSPvASRIDrtrlaAAGWSMggG 173
Cdd:COG1075     8 VVLVHGLGGSAASWAPLAPRLRAAGYPVYALNyPSTNGSIED-SAEQLAAFVDAVLAATG-AEKVD-----LVGHSM--G 78

                          90       100
                  ....*....|....*....|....*
gi 1110581546 174 GLR-RAALQR----PSLKAIVGMAP 193
Cdd:COG1075    79 GLVaRYYLKRlggaAKVARVVTLGT 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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