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Conserved domains on  [gi|1110512917|emb|SHI67683|]
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Helicase conserved C-terminal domain-containing protein, partial [Nocardiopsis flavescens]

Protein Classification

DEAD/DEAH box helicase( domain architecture ID 11423521)

DEAD/DEAH box-containing ATP-dependent helicase catalyzes the unwinding of DNA or RNA

EC:  3.6.4.-
Gene Ontology:  GO:0016887|GO:0003676|GO:0005524
PubMed:  20206133
SCOP:  4000282|3002019

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
61-402 8.64e-162

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


:

Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 460.77  E-value: 8.64e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrTAEPRRPLAVVLAPT 140
Cdd:COG0513     3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD--PSRPRAPQALILAPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:COG0513    81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE- 299
Cdd:COG0513   161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEd 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 -GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPT 378
Cdd:COG0513   241 pERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
                         330       340
                  ....*....|....*....|....
gi 1110512917 379 DHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0513   321 DPEDYVHRIGRTGRAGAEGTAISL 344
 
Name Accession Description Interval E-value
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
61-402 8.64e-162

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 460.77  E-value: 8.64e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrTAEPRRPLAVVLAPT 140
Cdd:COG0513     3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD--PSRPRAPQALILAPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:COG0513    81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE- 299
Cdd:COG0513   161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEd 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 -GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPT 378
Cdd:COG0513   241 pERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
                         330       340
                  ....*....|....*....|....
gi 1110512917 379 DHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0513   321 DPEDYVHRIGRTGRAGAEGTAISL 344
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
57-402 2.80e-90

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 279.76  E-value: 2.80e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  57 PAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVV 136
Cdd:PRK11776    1 MSMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLD---VKRFRVQALV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEAD 215
Cdd:PRK11776   78 LCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEAD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDlSEGAVSTMEHHVVHVSPAEK-KAVATR 294
Cdd:PRK11776  158 RMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVE-STHDLPAIEQRFYEVSPDERlPALQRL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 295 IA-AREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PRK11776  237 LLhHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVIN 316
                         330       340
                  ....*....|....*....|....*....
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK11776  317 YELARDPEVHVHRIGRTGRAGSKGLALSL 345
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
71-262 6.35e-84

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 254.29  E-value: 6.35e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMD-GRTAEPRRPLAVVLAPTRELAQQVAD 149
Cdd:cd00268     1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLpEPKKKGRGPQALVLAPTRELAMQIAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd00268    81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd00268   161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPV 193
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
84-253 1.91e-52

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 172.43  E-value: 1.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  84 SEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPTRELAQQVADSLEPYARSVGVRTA 163
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQ---ALVLAPTRELAEQIYEELKKLGKGLGLKVA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 164 TVVGGMPIHRQARSLRqGVHLVVATPGRLRDLMERGDcVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRRMLFS 243
Cdd:pfam00270  78 SLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLS 155
                         170
                  ....*....|
gi 1110512917 244 ATLDRNVDTL 253
Cdd:pfam00270 156 ATLPRNLEDL 165
DEXDc smart00487
DEAD-like helicases superfamily;
75-267 3.28e-45

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 154.96  E-value: 3.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917   75 LARQGLTTPSEIQAATLPNSLAG-RDVLGRSRTGSGKTLAFGLALLAGMDgrtaEPRRPLAVVLAPTRELAQQVADSLEP 153
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTRELAEQWAEELKK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  154 YARSVGVRTATVVGGMPIHRQARSLRQGV-HLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE 232
Cdd:smart00487  77 LGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1110512917  233 VPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVD 267
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVG 191
 
Name Accession Description Interval E-value
SrmB COG0513
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
61-402 8.64e-162

Superfamily II DNA and RNA helicase [Replication, recombination and repair];


Pssm-ID: 440279 [Multi-domain]  Cd Length: 420  Bit Score: 460.77  E-value: 8.64e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrTAEPRRPLAVVLAPT 140
Cdd:COG0513     3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLLQRLD--PSRPRAPQALILAPT 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:COG0513    81 RELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDEADRMLDM 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE- 299
Cdd:COG0513   161 GFIEDIERILKLLPKERQTLLFSATMPPEIRKLAKRYLKNPVRIEVAPENATAETIEQRYYLVDKRDKLELLRRLLRDEd 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 -GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPT 378
Cdd:COG0513   241 pERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAFRNGKIRVLVATDVAARGIDIDDVSHVINYDLPE 320
                         330       340
                  ....*....|....*....|....
gi 1110512917 379 DHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0513   321 DPEDYVHRIGRTGRAGAEGTAISL 344
PRK11776 PRK11776
ATP-dependent RNA helicase DbpA; Provisional
57-402 2.80e-90

ATP-dependent RNA helicase DbpA; Provisional


Pssm-ID: 236977 [Multi-domain]  Cd Length: 460  Bit Score: 279.76  E-value: 2.80e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  57 PAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVV 136
Cdd:PRK11776    1 MSMTAFSTLPLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLLQKLD---VKRFRVQALV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEAD 215
Cdd:PRK11776   78 LCPTRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEAD 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDlSEGAVSTMEHHVVHVSPAEK-KAVATR 294
Cdd:PRK11776  158 RMLDMGFQDAIDAIIRQAPARRQTLLFSATYPEGIAAISQRFQRDPVEVKVE-STHDLPAIEQRFYEVSPDERlPALQRL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 295 IA-AREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PRK11776  237 LLhHQPESCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFANRSCSVLVATDVAARGLDIKALEAVIN 316
                         330       340
                  ....*....|....*....|....*....
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK11776  317 YELARDPEVHVHRIGRTGRAGSKGLALSL 345
DEADc cd00268
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ...
71-262 6.35e-84

DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350669 [Multi-domain]  Cd Length: 196  Bit Score: 254.29  E-value: 6.35e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMD-GRTAEPRRPLAVVLAPTRELAQQVAD 149
Cdd:cd00268     1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLpEPKKKGRGPQALVLAPTRELAMQIAE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd00268    81 VARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEEDVEKI 160
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd00268   161 LSALPKDRQTLLFSATLPEEVKELAKKFLKNPV 193
PTZ00110 PTZ00110
helicase; Provisional
60-397 5.63e-78

helicase; Provisional


Pssm-ID: 240273 [Multi-domain]  Cd Length: 545  Bit Score: 250.46  E-value: 5.63e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRR-----PLA 134
Cdd:PTZ00110  130 VSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTLAF---LLPAIVHINAQPLLrygdgPIV 206
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 135 VVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEA 214
Cdd:PTZ00110  207 LVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILIACPGRLIDFLESNVTNLRRVTYLVLDEA 286
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 215 DQMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVH----SVDLSegAVSTMEHHVVHVSPAEKKA 290
Cdd:PTZ00110  287 DRMLDMGFEPQIRKIVSQIRPDRQTLMWSATWPKEVQSLARDLCKEEPVHvnvgSLDLT--ACHNIKQEVFVVEEHEKRG 364
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 291 ----VATRIAAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVD 366
Cdd:PTZ00110  365 klkmLLQRIMRDGDKILIFVETKKGADFLTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVK 444
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1110512917 367 GLDLVVNIDPPTDHKDYLHRGGRTARAGESG 397
Cdd:PTZ00110  445 DVKYVINFDFPNQIEDYVHRIGRTGRAGAKG 475
PRK01297 PRK01297
ATP-dependent RNA helicase RhlB; Provisional
42-397 6.90e-78

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 234938 [Multi-domain]  Cd Length: 475  Bit Score: 248.29  E-value: 6.90e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  42 PSGEFALPVTVTPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG 121
Cdd:PRK01297   69 PASLWKLEDFVVEPQEGKTRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISIINQ 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 122 MDGRTAEPRR----PLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLR-QGVHLVVATPGRLRDLM 196
Cdd:PRK01297  149 LLQTPPPKERymgePRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEaRFCDILVATPGRLLDFN 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 197 ERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVS 274
Cdd:PRK01297  229 QRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEERqtLLFSATFTDDVMNLAKQWTTDPAIVEIEPENVASD 308
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 275 TMEHHVVHVSPAEKKAVATRIAAREG--RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTA 352
Cdd:PRK01297  309 TVEQHVYAVAGSDKYKLLYNLVTQNPweRVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGFREGKIRV 388
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1110512917 353 LIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESG 397
Cdd:PRK01297  389 LVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASG 433
PRK11192 PRK11192
ATP-dependent RNA helicase SrmB; Provisional
62-402 4.14e-74

ATP-dependent RNA helicase SrmB; Provisional


Pssm-ID: 236877 [Multi-domain]  Cd Length: 434  Bit Score: 237.53  E-value: 4.14e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGL-ALLAGMDGRTAEPRRPLAVVLAPT 140
Cdd:PRK11192    3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLpALQHLLDFPRRKSGPPRILILTPT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLM--ERGDCvlDRVESAVLDEADQMT 218
Cdd:PRK11192   83 RELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIkeENFDC--RAVETLILDEADRML 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 219 DMGFMPQVTAILQEvpAGGRR--MLFSATLD-RNVDTLVRRFLNDPVVHSVDLS--EGAV--------STMEHhvvhvsp 285
Cdd:PRK11192  161 DMGFAQDIETIAAE--TRWRKqtLLFSATLEgDAVQDFAERLLNDPVEVEAEPSrrERKKihqwyyraDDLEH------- 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 286 aeKKAVATRIAARE--GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGI 363
Cdd:PRK11192  232 --KTALLCHLLKQPevTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIKRLTDGRVNVLVATDVAARGI 309
                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1110512917 364 HVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK11192  310 DIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
PRK10590 PRK10590
ATP-dependent RNA helicase RhlE; Provisional
61-402 1.34e-73

ATP-dependent RNA helicase RhlE; Provisional


Pssm-ID: 236722 [Multi-domain]  Cd Length: 456  Bit Score: 236.63  E-value: 1.34e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEP--RRPL-AVVL 137
Cdd:PRK10590    2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQPHAkgRRPVrALIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PRK10590   82 TPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDEADRM 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAA 297
Cdd:PRK10590  162 LDMGFIHDIRRVLAKLPAKRQNLLFSATFSDDIKALAEKLLHNPLEIEVARRNTASEQVTQHVHFVDKKRKRELLSQMIG 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REG--RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNID 375
Cdd:PRK10590  242 KGNwqQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADFKSGDIRVLVATDIAARGLDIEELPHVVNYE 321
                         330       340
                  ....*....|....*....|....*..
gi 1110512917 376 PPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK10590  322 LPNVPEDYVHRIGRTGRAAATGEALSL 348
PRK11634 PRK11634
ATP-dependent RNA helicase DeaD; Provisional
61-397 1.79e-71

ATP-dependent RNA helicase DeaD; Provisional


Pssm-ID: 236941 [Multi-domain]  Cd Length: 629  Bit Score: 235.90  E-value: 1.79e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPT 140
Cdd:PRK11634    7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLLHNLD---PELKAPQILVLAPT 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTD 219
Cdd:PRK11634   84 RELAVQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDEADEMLR 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIAARE 299
Cdd:PRK11634  164 MGFIEDVETIMAQIPEGHQTALFSATMPEAIRRITRRFMKEPQEVRIQSSVTTRPDISQSYWTVWGMRKNEALVRFLEAE 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 --GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPP 377
Cdd:PRK11634  244 dfDAAIIFVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLERLKDGRLDILIATDVAARGLDVERISLVVNYDIP 323
                         330       340
                  ....*....|....*....|
gi 1110512917 378 TDHKDYLHRGGRTARAGESG 397
Cdd:PRK11634  324 MDSESYVHRIGRTGRAGRAG 343
PRK04537 PRK04537
ATP-dependent RNA helicase RhlB; Provisional
61-402 2.19e-68

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235307 [Multi-domain]  Cd Length: 572  Bit Score: 226.37  E-value: 2.19e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTA----EPRRPLAVV 136
Cdd:PRK04537   10 TFSSFDLHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPAladrKPEDPRALI 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEAD 215
Cdd:PRK04537   90 LAPTRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVsLHACEICVLDEAD 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVAT 293
Cdd:PRK04537  170 RMFDLGFIKDIRFLLRRMPERGTRqtLLFSATLSHRVLELAYEHMNEPEKLVVETETITAARVRQRIYFPADEEKQTLLL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 294 RIAAR-EG-RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLV 371
Cdd:PRK04537  250 GLLSRsEGaRTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQLEILVATDVAARGLHIDGVKYV 329
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1110512917 372 VNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK04537  330 YNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
PRK04837 PRK04837
ATP-dependent RNA helicase RhlB; Provisional
62-402 5.77e-67

ATP-dependent RNA helicase RhlB; Provisional


Pssm-ID: 235314 [Multi-domain]  Cd Length: 423  Bit Score: 218.30  E-value: 5.77e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLA----LLAGMDGRTAEPRRPLAVVL 137
Cdd:PRK04837   10 FSDFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTAtfhyLLSHPAPEDRKVNQPRALIM 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PRK04837   90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRM 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRR--MLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRI 295
Cdd:PRK04837  170 FDLGFIKDIRWLFRRMPPANQRlnMLFSATLSYRVRELAFEHMNNPEYVEVEPEQKTGHRIKEELFYPSNEEKMRLLQTL 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 296 AARE--GRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PRK04837  250 IEEEwpDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGDLDILVATDVAARGLHIPAVTHVFN 329
                         330       340
                  ....*....|....*....|....*....
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:PRK04837  330 YDLPDDCEDYVHRIGRTGRAGASGHSISL 358
DEADc_DDX3_DDX4 cd17967
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ...
61-260 5.69e-61

DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350725 [Multi-domain]  Cd Length: 221  Bit Score: 196.55  E-value: 5.69e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM----------DGRTAEPR 130
Cdd:cd17967     1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIISKLledgppsvgrGRRKAYPS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 131 rplAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAV 210
Cdd:cd17967    81 ---ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLV 157
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 211 LDEADQMTDMGFMPQVTAILQE---VPAGGRR-MLFSATLDRNVDTLVRRFLND 260
Cdd:cd17967   158 LDEADRMLDMGFEPQIRKIVEHpdmPPKGERQtLMFSATFPREIQRLAADFLKN 211
DEADc_DDX49 cd17955
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ...
62-265 8.20e-58

DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350713 [Multi-domain]  Cd Length: 204  Bit Score: 187.82  E-value: 8.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrTAEPRRPLAVVLAPTR 141
Cdd:cd17955     1 FEDLGLSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPILQRL---SEDPYGIFALVLTPTR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGD---CVLDRVESAVLDEADQMT 218
Cdd:cd17955    78 ELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDdttKVLSRVKFLVLDEADRLL 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHS 265
Cdd:cd17955   158 TGSFEDDLATILSALPPKRQTLLFSATLTDALKALKELFGNKPFFWE 204
PLN00206 PLN00206
DEAD-box ATP-dependent RNA helicase; Provisional
61-400 1.83e-57

DEAD-box ATP-dependent RNA helicase; Provisional


Pssm-ID: 215103 [Multi-domain]  Cd Length: 518  Bit Score: 196.16  E-value: 1.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG----MDGRTAEPRRPLAVV 136
Cdd:PLN00206  122 SFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTASFLVPIISRcctiRSGHPSEQRNPLAMV 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 137 LAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQ 216
Cdd:PLN00206  202 LTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELIVGTPGRLIDLLSKHDIELDNVSVLVLDEVDC 281
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 217 MTDMGFMPQVTAILQEVPAgGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKAVATRIA 296
Cdd:PLN00206  282 MLERGFRDQVMQIFQALSQ-PQVLLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDIL 360
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 297 AREGR----VIMFLDTKRAVDRMAEHL-LASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLV 371
Cdd:PLN00206  361 KSKQHfkppAVVFVSSRLGADLLANAItVVTGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQV 440
                         330       340
                  ....*....|....*....|....*....
gi 1110512917 372 VNIDPPTDHKDYLHRGGRTARAGESGNVV 400
Cdd:PLN00206  441 IIFDMPNTIKEYIHQIGRASRMGEKGTAI 469
PTZ00424 PTZ00424
helicase 45; Provisional
58-401 1.83e-57

helicase 45; Provisional


Pssm-ID: 185609 [Multi-domain]  Cd Length: 401  Bit Score: 193.12  E-value: 1.83e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  58 AAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVL 137
Cdd:PTZ00424   26 IVDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQLIDYDLNACQ---ALIL 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM 217
Cdd:PTZ00424  103 APTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILDEADEM 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 218 TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVDLSEGAVSTMEHHVVHVSPAEKKaVATRIAA 297
Cdd:PTZ00424  183 LSRGFKGQIYDVFKKLPPDVQVALFSATMPNEILELTTKFMRDPKRILVKKDELTLEGIRQFYVAVEKEEWK-FDTLCDL 261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REG----RVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVN 373
Cdd:PTZ00424  262 YETltitQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMREFRSGSTRVLITTDLLARGIDVQQVSLVIN 341
                         330       340       350
                  ....*....|....*....|....*....|.
gi 1110512917 374 IDPPTDHKDYLHRGGRTARAGESG---NVVT 401
Cdd:PTZ00424  342 YDLPASPENYIHRIGRSGRFGRKGvaiNFVT 372
DEADc_DDX23 cd17945
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ...
71-263 3.53e-57

DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350703 [Multi-domain]  Cd Length: 220  Bit Score: 186.76  E-value: 3.53e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR-----PLAVVLAPTRELAQ 145
Cdd:cd17945     1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLDEEtkddgPYALILAPTRELAQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 146 QVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQ 225
Cdd:cd17945    81 QIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEPQ 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 226 VTAILQEVP----------------AGGRR----MLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17945   161 VTKILDAMPvsnkkpdteeaeklaaSGKHRyrqtMMFTATMPPAVEKIAKGYLRRPVV 218
DEADc_DDX47 cd17954
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ...
61-262 7.72e-57

DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350712 [Multi-domain]  Cd Length: 203  Bit Score: 185.21  E-value: 7.72e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrTAEPRRPLAVVLAPT 140
Cdd:cd17954     1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQAL---LENPQRFFALVLAPT 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEADQMTD 219
Cdd:cd17954    78 RELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENTKGFsLKSLKFLVMDEADRLLN 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17954   158 MDFEPEIDKILKVIPRERTTYLFSATMTTKVAKLQRASLKNPV 200
DEADc_DDX5_DDX17 cd17966
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ...
75-262 2.80e-55

DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350724 [Multi-domain]  Cd Length: 197  Bit Score: 181.03  E-value: 2.80e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRR-----PLAVVLAPTRELAQQVAD 149
Cdd:cd17966     5 LKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAF---LLPAIVHINAQPPLergdgPIVLVLAPTRELAQQIQQ 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17966    82 EANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEPQIRKI 161
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17966   162 VDQIRPDRQTLMWSATWPKEVRRLAEDFLKDYI 194
DEADc_DDX46 cd17953
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ...
61-262 3.24e-53

DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350711 [Multi-domain]  Cd Length: 222  Bit Score: 176.41  E-value: 3.24e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR-PLAVVLA 138
Cdd:cd17953    13 KWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHiKDQRPVKPGEgPIGLIMA 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGD---CVLDRVESAVLDEAD 215
Cdd:cd17953    93 PTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILTANNgrvTNLRRVTYVVLDEAD 172
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1110512917 216 QMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17953   173 RMFDMGFEPQIMKIVNNIRPDRQTVLFSATFPRKVEALARKVLHKPI 219
DEADc_DDX42 cd17952
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ...
75-263 4.33e-53

DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350710 [Multi-domain]  Cd Length: 197  Bit Score: 175.30  E-value: 4.33e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR-PLAVVLAPTRELAQQVADSLE 152
Cdd:cd17952     5 IRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHiMDQRELEKGEgPIAVIVAPTRELAQQIYLEAK 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 153 PYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE 232
Cdd:cd17952    85 KFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEYQVRSIVGH 164
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1110512917 233 VPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17952   165 VRPDRQTLLFSATFKKKIEQLARDILSDPIR 195
DEADc_DDX27 cd17947
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ...
71-262 1.20e-52

DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350705 [Multi-domain]  Cd Length: 196  Bit Score: 173.98  E-value: 1.20e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17947     1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPKKKAATRVLVLVPTRELAMQCFSV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17947    81 LQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFdLDSIEILVLDEADRMLEEGFADELKEI 160
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17947   161 LRLCPRTRQTMLFSATMTDEVKDLAKLSLNKPV 193
DEAD pfam00270
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ...
84-253 1.91e-52

DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.


Pssm-ID: 425570 [Multi-domain]  Cd Length: 165  Bit Score: 172.43  E-value: 1.91e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  84 SEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPTRELAQQVADSLEPYARSVGVRTA 163
Cdd:pfam00270   1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGPQ---ALVLAPTRELAEQIYEELKKLGKGLGLKVA 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 164 TVVGGMPIHRQARSLRqGVHLVVATPGRLRDLMERGDcVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRRMLFS 243
Cdd:pfam00270  78 SLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERK-LLKNLKLLVLDEAHRLLDMGFGPDLEEILRRLPKKRQILLLS 155
                         170
                  ....*....|
gi 1110512917 244 ATLDRNVDTL 253
Cdd:pfam00270 156 ATLPRNLEDL 165
DEADc_DDX24 cd17946
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ...
71-259 3.37e-50

DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350704 [Multi-domain]  Cd Length: 235  Bit Score: 168.96  E-value: 3.37e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLA-GRDVLGRSRTGSGKTLAFGLALLAGM------DGRTAEPRRPLAVVLAPTREL 143
Cdd:cd17946     1 ILRALADLGFSEPTPIQALALPAAIRdGKDVIGAAETGSGKTLAFGIPILERLlsqkssNGVGGKQKPLRALILTPTREL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 144 AQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESA---VLDEADQMTDM 220
Cdd:cd17946    81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQEGNEHLANLKSLrflVLDEADRMLEK 160
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1110512917 221 GFMPQVTAIL---QEVPAGGRR----MLFSATLDRNVDTLVRRFLN 259
Cdd:cd17946   161 GHFAELEKILellNKDRAGKKRkrqtFVFSATLTLDHQLPLKLNSK 206
DEADc_DDX4 cd18052
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ...
47-259 6.74e-49

DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350810 [Multi-domain]  Cd Length: 264  Bit Score: 166.68  E-value: 6.74e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  47 ALPVTVT----PalPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM 122
Cdd:cd18052    28 EIPVEVTgrnpP--PAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVLTGM 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 123 --DGRTA----EPRRPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLM 196
Cdd:cd18052   106 mkEGLTAssfsEVQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFI 185
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1110512917 197 ERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE--VPAGGRR--MLFSATLDRNVDTLVRRFLN 259
Cdd:cd18052   186 GRGKISLSKLKYLILDEADRMLDMGFGPEIRKLVSEpgMPSKEDRqtLMFSATFPEEIQRLAAEFLK 252
DEADc_DDX3 cd18051
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ...
60-260 1.51e-48

DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350809 [Multi-domain]  Cd Length: 249  Bit Score: 165.21  E-value: 1.51e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM------DGRTAEPRR-- 131
Cdd:cd18051    21 ETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIyeqgpgESLPSESGYyg 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 132 -----PLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRV 206
Cdd:cd18051   101 rrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPGRLVDMLERGKIGLDYC 180
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 207 ESAVLDEADQMTDMGFMPQVTAILQE---VPAGGRRML-FSATLDRNVDTLVRRFLND 260
Cdd:cd18051   181 KYLVLDEADRMLDMGFEPQIRRIVEQdtmPPTGERQTLmFSATFPKEIQMLARDFLDN 238
SF2_C_DEAD cd18787
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ...
277-402 1.75e-46

C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350174 [Multi-domain]  Cd Length: 131  Bit Score: 155.74  E-value: 1.75e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 277 EHHVVHVSPAEKKAVATRI---AAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTAL 353
Cdd:cd18787     2 KQLYVVVEEEEKKLLLLLLlleKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRVL 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1110512917 354 IATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:cd18787    82 VATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITF 130
DEADc_MSS116 cd17964
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ...
70-259 2.63e-46

DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350722 [Multi-domain]  Cd Length: 211  Bit Score: 158.13  E-value: 2.63e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  70 ALKRTLARQGLTTPSEIQAATLPNSLA-GRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRP--LAVVLAPTRELAQQ 146
Cdd:cd17964     4 SLLKALTRMGFETMTPVQQKTLKPILStGDDVLARAKTGTGKTLAFLLPAIQSLLNTKPAGRRSgvSALIISPTRELALQ 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VAD---SLEPYARSVGVRTAtvVGGMPIHRQARSL-RQGVHLVVATPGRLRDLME--RGDCVLDRVESAVLDEADQMTDM 220
Cdd:cd17964    84 IAAeakKLLQGLRKLRVQSA--VGGTSRRAELNRLrRGRPDILVATPGRLIDHLEnpGVAKAFTDLDYLVLDEADRLLDM 161
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1110512917 221 GFMPQVTAILQEVP---AGGRR-MLFSATLDRNVDTLVRRFLN 259
Cdd:cd17964   162 GFRPDLEQILRHLPeknADPRQtLLFSATVPDEVQQIARLTLK 204
DEADc_EIF4A cd17939
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ...
66-262 1.37e-45

DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350697 [Multi-domain]  Cd Length: 199  Bit Score: 155.95  E-value: 1.37e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  66 DMPeaLKRTLAR----QGLTTPSEI-QAATLPNSLaGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPT 140
Cdd:cd17939     1 DMG--LSEDLLRgiyaYGFEKPSAIqQRAIVPIIK-GRDVIAQAQSGTGKTATFSIGALQRIDTTVRETQ---ALVLAPT 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 141 RELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM 220
Cdd:cd17939    75 RELAQQIQKVVKALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSR 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17939   155 GFKDQIYDIFQFLPPETQVVLFSATMPHEVLEVTKKFMRDPV 196
DEXDc smart00487
DEAD-like helicases superfamily;
75-267 3.28e-45

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 154.96  E-value: 3.28e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917   75 LARQGLTTPSEIQAATLPNSLAG-RDVLGRSRTGSGKTLAFGLALLAGMDgrtaEPRRPLAVVLAPTRELAQQVADSLEP 153
Cdd:smart00487   1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPALEALK----RGKGGRVLVLVPTRELAEQWAEELKK 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  154 YARSVGVRTATVVGGMPIHRQARSLRQGV-HLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQE 232
Cdd:smart00487  77 LGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQLEKLLKL 156
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1110512917  233 VPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSVD 267
Cdd:smart00487 157 LPKNVQLLLLSATPPEEIENLLELFLNDPVFIDVG 191
DEADc_DDX5 cd18049
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ...
62-262 7.16e-45

DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350807 [Multi-domain]  Cd Length: 234  Bit Score: 155.17  E-value: 7.16e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR--PLAVVLAP 139
Cdd:cd18049    26 FYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVHINHQPFLERGdgPICLVLAP 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 140 TRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTD 219
Cdd:cd18049   106 TRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLD 185
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1110512917 220 MGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18049   186 MGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLKDYI 228
DEADc_DDX54 cd17959
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ...
61-263 4.42e-44

DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350717 [Multi-domain]  Cd Length: 205  Bit Score: 152.07  E-value: 4.42e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAE--PRrplAVVLA 138
Cdd:cd17959     2 GFQSMGLSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPMIEKLKAHSPTvgAR---ALILS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMT 218
Cdd:cd17959    79 PTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQFEALASNPDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRLF 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17959   159 EMGFAEQLHEILSRLPENRQTLLFSATLPKLLVEFAKAGLNEPVL 203
DEADc_DDX55 cd17960
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ...
71-262 2.46e-43

DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350718 [Multi-domain]  Cd Length: 202  Bit Score: 150.03  E-value: 2.46e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRP--LAVVLAPTRELAQQVA 148
Cdd:cd17960     1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVLEILLKRKANLKKGqvGALIISPTRELATQIY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 149 DSLEPYARSVG--VRTATVVGGM-PIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLD--RVESAVLDEADQMTDMGFM 223
Cdd:cd17960    81 EVLQSFLEHHLpkLKCQLLIGGTnVEEDVKKFKRNGPNILVGTPGRLEELLSRKADKVKvkSLEVLVLDEADRLLDLGFE 160
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1110512917 224 PQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17960   161 ADLNRILSKLPKQRRTGLFSATQTDAVEELIKAGLRNPV 199
DEADc_DDX17 cd18050
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ...
61-262 3.55e-43

DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350808 [Multi-domain]  Cd Length: 271  Bit Score: 151.70  E-value: 3.55e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  61 SFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR--PLAVVLA 138
Cdd:cd18050    63 AFHQANFPQYVMDVLLDQNFKEPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLERGdgPICLVLA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 139 PTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMT 218
Cdd:cd18050   143 PTRELAQQVQQVADDYGKSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRML 222
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1110512917 219 DMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18050   223 DMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYV 266
DEADc_DDX41 cd17951
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ...
73-263 3.89e-43

DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350709 [Multi-domain]  Cd Length: 206  Bit Score: 149.80  E-value: 3.89e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAG-MDGRTAEPRR----PLAVVLAPTRELAQQV 147
Cdd:cd17951     3 KGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFaLEQEKKLPFIkgegPYGLIVCPSRELARQT 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 ADSLEPYARSV------GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd17951    83 HEVIEYYCKALqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEADRMIDMG 162
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17951   163 FEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSALVKPVT 204
DEADc_DDX6 cd17940
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ...
71-262 1.49e-41

DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350698 [Multi-domain]  Cd Length: 201  Bit Score: 145.13  E-value: 1.49e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLAR----QGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQ 146
Cdd:cd17940     6 LKRELLMgifeKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPILEKID---PKKDVIQALILVPTRELALQ 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQV 226
Cdd:cd17940    83 TSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEADKLLSQDFQPII 162
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1110512917 227 TAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17940   163 EKILNFLPKERQILLFSATFPLTVKNFMDRHMHNPY 198
DEADc_DDX10 cd17941
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ...
72-266 1.64e-41

DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350699 [Multi-domain]  Cd Length: 198  Bit Score: 145.13  E-value: 1.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  72 KRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALL--------AGMDGRTaeprrplAVVLAPTREL 143
Cdd:cd17941     2 LKGLKEAGFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPLLeklyrerwTPEDGLG-------ALIISPTREL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 144 AQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQgVHLVVATPGRLRDLMERG---DCvlDRVESAVLDEADQMTDM 220
Cdd:cd17941    75 AMQIFEVLRKVGKYHSFSAGLIIGGKDVKEEKERINR-MNILVCTPGRLLQHMDETpgfDT--SNLQMLVLDEADRILDM 151
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1110512917 221 GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVVHSV 266
Cdd:cd17941   152 GFKETLDAIVENLPKSRQTLLFSATQTKSVKDLARLSLKNPEYISV 197
DEADc_DDX52 cd17957
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ...
71-262 4.14e-41

DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350715 [Multi-domain]  Cd Length: 198  Bit Score: 143.88  E-value: 4.14e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17957     1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPILQKL-GKPRKKKGLRALILAPTRELASQIYRE 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSVGVRTATVVGGM-PIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17957    80 LLKLSKGTGLRIVLLSKSLeAKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPGFREQTDEI 159
                         170       180       190
                  ....*....|....*....|....*....|....
gi 1110512917 230 LQEVPAGG-RRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17957   160 LAACTNPNlQRSLFSATIPSEVEELARSVMKDPI 193
DEADc_DDX59 cd17962
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ...
71-262 9.09e-41

DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350720 [Multi-domain]  Cd Length: 193  Bit Score: 143.07  E-value: 9.09e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFglaLLAGMDGRTAEPRRPLAVVLAPTRELAQQVADS 150
Cdd:cd17962     1 LSSNLKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAF---LLPVIIRCLTEHRNPSALILTPTRELAVQIEDQ 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSV-GVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17962    78 AKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVLDI 157
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 230 LQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17962   158 LENISHDHQTILVSATIPRGIEQLAGQLLQNPV 190
DEADc_DDX20 cd17943
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ...
73-263 3.69e-40

DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350701 [Multi-domain]  Cd Length: 192  Bit Score: 141.25  E-value: 3.69e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQVADSLE 152
Cdd:cd17943     3 EGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIALESLD---LERRHPQVLILAPTREIAVQIHDVFK 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 153 PYARSV-GVRTATVVGGMPIHRQARSLRqGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQ 231
Cdd:cd17943    80 KIGKKLeGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQKDVNWIFS 158
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1110512917 232 EVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17943   159 SLPKNKQVIAFSATYPKNLDNLLARYMRKPVL 190
DEADc_DDX56 cd17961
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ...
71-263 5.42e-40

DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350719 [Multi-domain]  Cd Length: 206  Bit Score: 141.18  E-value: 5.42e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGM---DGRTAEPRRPLAVVLAPTRELAQQV 147
Cdd:cd17961     5 LLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKIlkaKAESGEEQGTRALILVPTRELAQQV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 AD---SLEPYARSVgVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERG-DCVLDRVESAVLDEADQMTDMGFM 223
Cdd:cd17961    85 SKvleQLTAYCRKD-VRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLESGsLLLLSTLKYLVIDEADLVLSYGYE 163
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1110512917 224 PQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17961   164 EDLKSLLSYLPKNYQTFLMSATLSEDVEALKKLVLHNPAI 203
DEADc_DDX31 cd17949
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ...
71-262 1.74e-38

DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350707 [Multi-domain]  Cd Length: 214  Bit Score: 137.72  E-value: 1.74e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLA-RQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLAL---LAGMDGRTAEPRRPLAVVLAPTRELAQQ 146
Cdd:cd17949     1 LVSHLKsKMGIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIiqrLLSLEPRVDRSDGTLALVLVPTRELALQ 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYAR-SVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDC-VLDRVESAVLDEADQMTDMGFMP 224
Cdd:cd17949    81 IYEVLEKLLKpFHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNTQSfDVSNLRWLVLDEADRLLDMGFEK 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1110512917 225 QVTAILQEV-------------PAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17949   161 DITKILELLddkrskaggekskPSRRQTVLVSATLTDGVKRLAGLSLKDPV 211
DEADc_DDX39 cd17950
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ...
68-262 1.17e-37

DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350708 [Multi-domain]  Cd Length: 208  Bit Score: 135.17  E-value: 1.17e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  68 PEALkRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTRELAQQV 147
Cdd:cd17950    11 PELL-RAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTLQQLE---PVDGQVSVLVICHTRELAFQI 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 148 ADSLEPYARSV-GVRTATVVGGMPIHRQARSLRQGV-HLVVATPGRLRDLMERGDCVLDRVESAVLDEADQM-TDMGFMP 224
Cdd:cd17950    87 SNEYERFSKYMpNVKTAVFFGGVPIKKDIEVLKNKCpHIVVGTPGRILALVREKKLKLSHVKHFVLDECDKMlEQLDMRR 166
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1110512917 225 QVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd17950   167 DVQEIFRATPHDKQVMMFSATLSKEIRPVCKKFMQDPL 204
DEADc_EIF4AII_EIF4AI_DDX2 cd18046
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ...
62-262 1.45e-37

DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350804 [Multi-domain]  Cd Length: 201  Bit Score: 134.88  E-value: 1.45e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTR 141
Cdd:cd18046     1 FDDMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISILQQID---TSLKATQALVLAPTR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd18046    78 ELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEMLSRG 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPV 262
Cdd:cd18046   158 FKDQIYDIFQKLPPDTQVVLLSATMPNDVLEVTTKFMRDPI 198
DEADc_DDX43_DDX53 cd17958
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ...
75-263 4.42e-36

DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350716 [Multi-domain]  Cd Length: 197  Bit Score: 130.66  E-value: 4.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  75 LARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAePR----RPLAVVLAPTRELAQQVADS 150
Cdd:cd17958     5 IKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLDLQPI-PReqrnGPGVLVLTPTRELALQIEAE 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 151 LEPYARSvGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAIL 230
Cdd:cd17958    84 CSKYSYK-GLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGFEPQIRKIL 162
                         170       180       190
                  ....*....|....*....|....*....|...
gi 1110512917 231 QEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17958   163 LDIRPDRQTIMTSATWPDGVRRLAQSYLKDPMI 195
DEADc_EIF4AIII_DDX48 cd18045
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ...
62-263 1.49e-35

DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350803 [Multi-domain]  Cd Length: 201  Bit Score: 129.51  E-value: 1.49e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  62 FAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPRRPLAVVLAPTR 141
Cdd:cd18045     1 FETMGLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVLQCLD---IQVRETQALILSPTR 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMG 221
Cdd:cd18045    78 ELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLNKG 157
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1110512917 222 FMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd18045   158 FKEQIYDVYRYLPPATQVVLVSATLPQDILEMTNKFMTDPIR 199
DEADc_DDX1 cd17938
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ...
67-246 1.20e-34

DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350696 [Multi-domain]  Cd Length: 204  Bit Score: 127.05  E-value: 1.20e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  67 MPEaLKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrtaeprrpLAVVLAPTRELAQQ 146
Cdd:cd17938     7 MPE-LIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVLQIV----------VALILEPSRELAEQ 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYAR---SVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFM 223
Cdd:cd17938    76 TYNCIENFKKyldNPKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLSQGNL 155
                         170       180
                  ....*....|....*....|....*....
gi 1110512917 224 PQVTAILQEVP---AGGRR---MLFSATL 246
Cdd:cd17938   156 ETINRIYNRIPkitSDGKRlqvIVCSATL 184
DEADc_DDX18 cd17942
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ...
72-261 3.92e-34

DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350700 [Multi-domain]  Cd Length: 198  Bit Score: 125.55  E-value: 3.92e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  72 KRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRRPLAV-VLAPTRELAQQ---- 146
Cdd:cd17942     2 LKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPRNGTGViIISPTRELALQiygv 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VADSLEPYARSVGVrtatVVGGMPIHRQARSLRQGVHLVVATPGRLRD-LMERGDCVLDRVESAVLDEADQMTDMGFMPQ 225
Cdd:cd17942    82 AKELLKYHSQTFGI----VIGGANRKAEAEKLGKGVNILVATPGRLLDhLQNTKGFLYKNLQCLIIDEADRILEIGFEEE 157
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1110512917 226 VTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDP 261
Cdd:cd17942   158 MRQIIKLLPKRRQTMLFSATQTRKVEDLARISLKKK 193
DEADc_DDX19_DDX25 cd17963
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ...
68-263 6.07e-34

DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350721 [Multi-domain]  Cd Length: 196  Bit Score: 125.00  E-value: 6.07e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  68 PEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVLAPTRELAQ 145
Cdd:cd17963     2 KPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAMLSRVDPTLKSPQ---ALCLAPTRELAR 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 146 QVADSLEPYARSVGVRTATVVGGMPIHRQARSlrqGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM-GFMP 224
Cdd:cd17963    79 QIGEVVEKMGKFTGVKVALAVPGNDVPRGKKI---TAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVMLDTqGHGD 155
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1110512917 225 QVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17963   156 QSIRIKRMLPRNCQILLFSATFPDSVRKFAEKIAPNANT 194
DEADc_DDX21_DDX50 cd17944
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ...
73-245 1.45e-33

DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.


Pssm-ID: 350702 [Multi-domain]  Cd Length: 202  Bit Score: 124.19  E-value: 1.45e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  73 RTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR---PLAVVLAPTRELAQQVAD 149
Cdd:cd17944     3 KLLQARGVTYLFPIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPLIEKLQEDQQPRKRgraPKVLVLAPTRELANQVTK 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVrtATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17944    83 DFKDITRKLSV--ACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEI 160
                         170       180
                  ....*....|....*....|....
gi 1110512917 230 L--------QEVPaggRRMLFSAT 245
Cdd:cd17944   161 LsvsykkdsEDNP---QTLLFSAT 181
DEADc_DDX51 cd17956
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ...
71-250 2.19e-27

DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350714 [Multi-domain]  Cd Length: 231  Bit Score: 108.49  E-value: 2.19e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  71 LKRTLARQGLTTPSEIQAATLPNSLAG---------RDVLGRSRTGSGKTLAFGLALLAGMDGRTAepRRPLAVVLAPTR 141
Cdd:cd17956     1 LLKNLQNNGITSAFPVQAAVIPWLLPSskstppyrpGDLCVSAPTGSGKTLAYVLPIVQALSKRVV--PRLRALIVVPTK 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 142 ELAQQVADSLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHL--------VVATPGRLRDLMERGDCV-LDRVESAVLD 212
Cdd:cd17956    79 ELVQQVYKVFESLCKGTGLKVVSLSGQKSFKKEQKLLLVDTSGrylsrvdiLVATPGRLVDHLNSTPGFtLKHLRFLVID 158
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 213 EADQMTDMGF---MPQVTAILQEVPAGG-----------------RRMLFSATLDRNV 250
Cdd:cd17956   159 EADRLLNQSFqdwLETVMKALGRPTAPDlgsfgdanllersvrplQKLLFSATLTRDP 216
DEADc_DDX28 cd17948
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ...
74-283 2.35e-27

DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350706 [Multi-domain]  Cd Length: 231  Bit Score: 108.22  E-value: 2.35e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  74 TLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRR----PLAVVLAPTRELAQQVAD 149
Cdd:cd17948     4 ILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPIIQRLLRYKLLAEGpfnaPRGLVITPSRELAEQIGS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 150 SLEPYARSVGVRTATVVGGMPIHRQARSLRQGVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAI 229
Cdd:cd17948    84 VAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDDSFNEKLSHF 163
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1110512917 230 LQEVPAGGRR-------------MLFSATLDRNVDTLvrrfLNDpvVHSVDLSEGAVSTMEHHVV-HV 283
Cdd:cd17948   164 LRRFPLASRRsentdgldpgtqlVLVSATMPSGVGEV----LSK--VIDVDSIETVTSDKLHRLMpHV 225
Helicase_C pfam00271
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ...
297-394 2.97e-27

Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.


Pssm-ID: 459740 [Multi-domain]  Cd Length: 109  Bit Score: 104.21  E-value: 2.97e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 297 AREGRVIMFLDTKRAVDrmAEHLL-ASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNID 375
Cdd:pfam00271  13 ERGGKVLIFSQTKKTLE--AELLLeKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPDVDLVINYD 90
                          90
                  ....*....|....*....
gi 1110512917 376 PPTDHKDYLHRGGRTARAG 394
Cdd:pfam00271  91 LPWNPASYIQRIGRAGRAG 109
DEADc_MRH4 cd17965
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ...
67-263 3.55e-23

DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350723 [Multi-domain]  Cd Length: 251  Bit Score: 97.45  E-value: 3.55e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  67 MPEALKRTLARQGLTTPSEIQAATLP---NSLAGRDVLGRSR-------------TGSGKTLAFGLALLAG--------- 121
Cdd:cd17965    15 IKEILKGSNKTDEEIKPSPIQTLAIKkllKTLMRKVTKQTSNeepklevfllaaeTGSGKTLAYLAPLLDYlkrqeqepf 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 122 -MDGRTAEPR----RPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGM-PIHRQ-ARSLRQGVHLVVATPGRLRD 194
Cdd:cd17965    95 eEAEEEYESAkdtgRPRSVILVPTHELVEQVYSVLKKLSHTVKLGIKTFSSGFgPSYQRlQLAFKGRIDILVTTPGKLAS 174
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 195 LMERGDCVLDRVESAVLDEADQMTDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd17965   175 LAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKHLILCSATIPKEFDKTLRKLFPDVVR 243
HELICc smart00490
helicase superfamily c-terminal domain;
313-394 4.10e-23

helicase superfamily c-terminal domain;


Pssm-ID: 197757 [Multi-domain]  Cd Length: 82  Bit Score: 92.27  E-value: 4.10e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  313 DRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTAR 392
Cdd:smart00490   1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80

                   ..
gi 1110512917  393 AG 394
Cdd:smart00490  81 AG 82
DEADc_DDX25 cd18048
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ...
53-263 2.41e-22

DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350806 [Multi-domain]  Cd Length: 229  Bit Score: 94.70  E-value: 2.41e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  53 TPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDgrtAEPR 130
Cdd:cd18048    11 TSPLFSVKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAMLSRVD---ALKL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 131 RPLAVVLAPTRELAQQVADSLEPYAR-SVGVRTATVVGGmpiHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVES 208
Cdd:cd18048    88 YPQCLCLSPTFELALQTGKVVEEMGKfCVGIQVIYAIRG---NRPGKGTDIEAQIVIGTPGTVLDWCFKLRLIdVTNISV 164
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1110512917 209 AVLDEADQMTDM-GFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDPVV 263
Cdd:cd18048   165 FVLDEADVMINVqGHSDHSVRVKRSMPKECQMLLFSATFEDSVWAFAERIVPDPNI 220
DEADc_DDX19 cd18047
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ...
60-261 7.02e-18

DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.


Pssm-ID: 350805 [Multi-domain]  Cd Length: 205  Bit Score: 81.30  E-value: 7.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  60 ESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAG--RDVLGRSRTGSGKTLAFGLALLAGMDGRTAEPRrplAVVL 137
Cdd:cd18047     1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAMLSQVEPANKYPQ---CLCL 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 138 APTRELAQQVADSLEPYARSV-GVRTATVVGGmpiHRQARSLRQGVHLVVATPGRLRDLMERGDCV-LDRVESAVLDEAD 215
Cdd:cd18047    78 SPTYELALQTGKVIEQMGKFYpELKLAYAVRG---NKLERGQKISEQIVIGTPGTVLDWCSKLKFIdPKKIKVFVLDEAD 154
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1110512917 216 QM-TDMGFMPQVTAILQEVPAGGRRMLFSATLDRNVDTLVRRFLNDP 261
Cdd:cd18047   155 VMiATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDP 201
SSL2 COG1061
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
106-402 2.07e-16

Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];


Pssm-ID: 440681 [Multi-domain]  Cd Length: 566  Bit Score: 80.84  E-value: 2.07e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLaFGLALLAgmdgRTAEPRRplAVVLAPTRELAQQVADSLEPYARSVGVRtatvvggmpihrqARSLRQGVHLV 185
Cdd:COG1061   109 TGTGKTV-LALALAA----ELLRGKR--VLVLVPRRELLEQWAEELRRFLGDPLAG-------------GGKKDSDAPIT 168
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 186 VATP------GRLRDLMERGDCVldrvesaVLDEADQMTDMGFmpqvTAILQEVPAGgRRMLFSATLDRNVDTLVRRFLN 259
Cdd:COG1061   169 VATYqslarrAHLDELGDRFGLV-------IIDEAHHAGAPSY----RRILEAFPAA-YRLGLTATPFRSDGREILLFLF 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 260 DPVVHSVDLSE----GAVSTMEHHVVHVS----------------------PAEKKAVATRIAAREG---RVIMFLDTKR 310
Cdd:COG1061   237 DGIVYEYSLKEaiedGYLAPPEYYGIRVDltderaeydalserlrealaadAERKDKILRELLREHPddrKTLVFCSSVD 316
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 311 AVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRT 390
Cdd:COG1061   317 HAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRG 396
                         330
                  ....*....|..
gi 1110512917 391 ARAGESGNVVTL 402
Cdd:COG1061   397 LRPAPGKEDALV 408
YprA COG1205
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ...
50-402 2.45e-15

ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];


Pssm-ID: 440818 [Multi-domain]  Cd Length: 758  Bit Score: 77.95  E-value: 2.45e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  50 VTVTPALPAAESFAALDMPEALKRTLARQGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAGMdgrtAEP 129
Cdd:COG1205    24 VRTIPAREARYAPWPDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVLEAL----LED 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 130 RRPLAVVLAPTRELAQQVADSLEPYARSVG--VRTATVVGGMPihRQARS-LRQGVHLVVATP-----------GRLRDL 195
Cdd:COG1205   100 PGATALYLYPTKALARDQLRRLRELAEALGlgVRVATYDGDTP--PEERRwIREHPDIVLTNPdmlhygllphhTRWARF 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 196 MERgdcvLDRVesaVLDEADQMTdmG-FMPQVTAILqevpaggRRML-----------F---SATLDrNVDTLVRRFLND 260
Cdd:COG1205   178 FRN----LRYV---VIDEAHTYR--GvFGSHVANVL-------RRLRricrhygsdpqFilaSATIG-NPAEHAERLTGR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 261 PVVHsVDLSeGAVSTMEHHVVHVSPAEKKAV-------ATRIAA---REG-RVIMFLDTKRAVDRMAEHL---LASGVLA 326
Cdd:COG1205   241 PVTV-VDED-GSPRGERTFVLWNPPLVDDGIrrsalaeAARLLAdlvREGlRTLVFTRSRRGAELLARYArraLREPDLA 318
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 327 ---APLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG1205   319 drvAAYRAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPGTRASFWQQAGRAGRRGQDSLVVLV 397
SF2-N cd00046
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ...
97-245 6.18e-15

N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.


Pssm-ID: 350668 [Multi-domain]  Cd Length: 146  Bit Score: 71.67  E-value: 6.18e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  97 GRDVLGRSRTGSGKTLAFGLALLagmdgRTAEPRRPLAVVLAPTRELAQQVADSLEPYARSvGVRTATVVGGMPIHRQAR 176
Cdd:cd00046     1 GENVLITAPTGSGKTLAALLAAL-----LLLLKKGKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSSAEEREK 74
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1110512917 177 SLRQGVHLVVATPGRLRDLMERGDC-VLDRVESAVLDEADQMT-DMGFMPQVT-AILQEVPAGGRRMLFSAT 245
Cdd:cd00046    75 NKLGDADIIIATPDMLLNLLLREDRlFLKDLKLIIVDEAHALLiDSRGALILDlAVRKAGLKNAQVILLSAT 146
RecQ COG0514
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
95-402 4.39e-13

Superfamily II DNA helicase RecQ [Replication, recombination and repair];


Pssm-ID: 440280 [Multi-domain]  Cd Length: 489  Bit Score: 70.55  E-value: 4.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  95 LAGRDVLGRSRTGSGKTLAFGL-ALLagMDGrtaeprrpLAVVLAPTRELAQ-QVaDSLepyaRSVGVRTATVVGGMPIH 172
Cdd:COG0514    30 LAGRDALVVMPTGGGKSLCYQLpALL--LPG--------LTLVVSPLIALMKdQV-DAL----RAAGIRAAFLNSSLSAE 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 173 RQA---RSLRQG-VHLVVATPGRL-----RDLMERGDCVLdrvesAVLDEA--------DqmtdmgFMP------QVTAI 229
Cdd:COG0514    95 ERRevlRALRAGeLKLLYVAPERLlnprfLELLRRLKISL-----FAIDEAhcisqwghD------FRPdyrrlgELRER 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 230 LQEVPaggrRMLFSATLDRNV-DTLVRRF-LNDP--VVHSVD-----LSegavstmehhVVHVSPAEKKA-VATRIAARE 299
Cdd:COG0514   164 LPNVP----VLALTATATPRVrADIAEQLgLEDPrvFVGSFDrpnlrLE----------VVPKPPDDKLAqLLDFLKEHP 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 300 GR--VIMFLdTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNvaARGIHVDGLDL--VVNID 375
Cdd:COG0514   230 GGsgIVYCL-SRKKVEELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVATI--AFGMGIDKPDVrfVIHYD 306
                         330       340
                  ....*....|....*....|....*..
gi 1110512917 376 PPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:COG0514   307 LPKSIEAYYQEIGRAGRDGLPAEALLL 333
BRR2 COG1204
Replicative superfamily II helicase [Replication, recombination and repair];
68-356 5.45e-11

Replicative superfamily II helicase [Replication, recombination and repair];


Pssm-ID: 440817 [Multi-domain]  Cd Length: 529  Bit Score: 64.15  E-value: 5.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  68 PEALKRTLARQGLT--TPSeiQAATLPNSL-AGRDVLGRSRTGSGKTLafgLALLAgMdgRTAEPRRPLAVVLAPTRELA 144
Cdd:COG1204     8 LEKVIEFLKERGIEelYPP--QAEALEAGLlEGKNLVVSAPTASGKTL---IAELA-I--LKALLNGGKALYIVPLRALA 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 145 QQVADSLEPYARSVGVRTATVVGgmPIHRQARSLRQgVHLVVATPGRLRDLMERGDCVLDRVESAVLDEADQMTDM--GF 222
Cdd:COG1204    80 SEKYREFKRDFEELGIKVGVSTG--DYDSDDEWLGR-YDILVATPEKLDSLLRNGPSWLRDVDLVVVDEAHLIDDEsrGP 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 223 MPQVT-AILQEVPAGGRRMLFSATLDrNVDTlVRRFLNDPVVHS----VDLSEGavsTMEHHVVHVSPAEKK------AV 291
Cdd:COG1204   157 TLEVLlARLRRLNPEAQIVALSATIG-NAEE-IAEWLDAELVKSdwrpVPLNEG---VLYDGVLRFDDGSRRskdptlAL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 292 ATRIAAREGRVIMFLDTKRAVDRMAEHL------------------LASGVLAAPL-------------------HGGRS 334
Cdd:COG1204   232 ALDLLEEGGQVLVFVSSRRDAESLAKKLadelkrrltpeereeleeLAEELLEVSEethtnekladclekgvafhHAGLP 311
                         330       340
                  ....*....|....*....|..
gi 1110512917 335 QPQRTRTLDQFKRGDVTALIAT 356
Cdd:COG1204   312 SELRRLVEDAFREGLIKVLVAT 333
SF2_C_dicer cd18802
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ...
334-396 3.98e-10

C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350189 [Multi-domain]  Cd Length: 142  Bit Score: 57.60  E-value: 3.98e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1110512917 334 SQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRtARAGES 396
Cdd:cd18802    75 TQRKQKETLDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
PRK11057 PRK11057
ATP-dependent DNA helicase RecQ; Provisional
87-394 4.27e-10

ATP-dependent DNA helicase RecQ; Provisional


Pssm-ID: 182933 [Multi-domain]  Cd Length: 607  Bit Score: 61.27  E-value: 4.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  87 QAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAgMDGrtaeprrpLAVVLAPTRELAQQVADSLEPYarsvGVRTATVV 166
Cdd:PRK11057   30 QQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV-LDG--------LTLVVSPLISLMKDQVDQLLAN----GVAAACLN 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 167 GGMPIHRQA---RSLRQG-VHLVVATPGRL--RDLMERgdcvLDRVESAVL--DEADQMTDMG--FMPQVTAILQ----- 231
Cdd:PRK11057   97 STQTREQQLevmAGCRTGqIKLLYIAPERLmmDNFLEH----LAHWNPALLavDEAHCISQWGhdFRPEYAALGQlrqrf 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 232 -EVPAggrrMLFSATLD---RNvDTLVRRFLNDPVVH--SVDLSEGAVSTMEHHvvhvSPAEKkaVATRIAAREGRV-IM 304
Cdd:PRK11057  173 pTLPF----MALTATADdttRQ-DIVRLLGLNDPLIQisSFDRPNIRYTLVEKF----KPLDQ--LMRYVQEQRGKSgII 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 305 FLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYL 384
Cdd:PRK11057  242 YCNSRAKVEDTAARLQSRGISAAAYHAGLDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYY 321
                         330
                  ....*....|
gi 1110512917 385 HRGGRTARAG 394
Cdd:PRK11057  322 QETGRAGRDG 331
MPH1 COG1111
ERCC4-related helicase [Replication, recombination and repair];
254-402 1.48e-09

ERCC4-related helicase [Replication, recombination and repair];


Pssm-ID: 440728 [Multi-domain]  Cd Length: 718  Bit Score: 59.74  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 254 VRRFLNDPVVHSvdlsegAVSTME-HHVVHvsPAEKKAV----ATRIAAREGRVIMFL---DTkraVDRMAEHLLASGVL 325
Cdd:COG1111   311 SKRLVSDPRFRK------AMRLAEeADIEH--PKLSKLReilkEQLGTNPDSRIIVFTqyrDT---AEMIVEFLSEPGIK 379
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 326 AAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDP-PTDHKdYLHRGGRTARAGEs 396
Cdd:COG1111   380 AGRFVGqaskegdkGLTQKEQIEILERFRAGEFNVLVATSVAEEGLDIPEVDLVIFYEPvPSEIR-SIQRKGRTGRKRE- 457

                  ....*.
gi 1110512917 397 GNVVTL 402
Cdd:COG1111   458 GRVVVL 463
SF2_C_FANCM_Hef cd18801
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ...
301-402 2.31e-08

C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350188 [Multi-domain]  Cd Length: 143  Bit Score: 52.74  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 301 RVIMFLDTKRAVDRMAEHLL--ASGVLAAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDL 370
Cdd:cd18801    32 RVIIFSEFRDSAEEIVNFLSkiRPGIRATRFIGqasgksskGMSQKEQKEVIEQFRKGGYNVLVATSIGEEGLDIGEVDL 111
                          90       100       110
                  ....*....|....*....|....*....|..
gi 1110512917 371 VVNIDPPTDHKDYLHRGGRTARaGESGNVVTL 402
Cdd:cd18801   112 IICYDASPSPIRMIQRMGRTGR-KRQGRVVVL 142
DEXHc_Ski2 cd17921
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ...
95-214 3.05e-08

DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350679 [Multi-domain]  Cd Length: 181  Bit Score: 53.03  E-value: 3.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  95 LAGRDVLGRSRTGSGKTLAFGLALLAGMdgRTAEPRrplAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGGMPIHRQ 174
Cdd:cd17921    15 LSGDSVLVSAPTSSGKTLIAELAILRAL--ATSGGK---AVYIAPTRALVNQKEADLRERFGPLGKNVGLLTGDPSVNKL 89
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1110512917 175 ARSLRQgvhLVVATPGRLrDLMER--GDCVLDRVESAVLDEA 214
Cdd:cd17921    90 LLAEAD---ILVATPEKL-DLLLRngGERLIQDVRLVVVDEA 127
PRK13766 PRK13766
Hef nuclease; Provisional
301-402 3.21e-08

Hef nuclease; Provisional


Pssm-ID: 237496 [Multi-domain]  Cd Length: 773  Bit Score: 55.65  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 301 RVIMFL---DTkraVDRMAEHLLASGVLAAPLHG--------GRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLD 369
Cdd:PRK13766  367 RIIVFTqyrDT---AEKIVDLLEKEGIKAVRFVGqaskdgdkGMSQKEQIEILDKFRAGEFNVLVSTSVAEEGLDIPSVD 443
                          90       100       110
                  ....*....|....*....|....*....|....
gi 1110512917 370 LVVNIDP-PTDHKdYLHRGGRTARaGESGNVVTL 402
Cdd:PRK13766  444 LVIFYEPvPSEIR-SIQRKGRTGR-QEEGRVVVL 475
DEXHc_Hrq1-like cd17923
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ...
87-214 1.83e-07

DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350681 [Multi-domain]  Cd Length: 182  Bit Score: 50.66  E-value: 1.83e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  87 QAATLPNSLAGRDVLGRSRTGSGKTLAFGLALLAgmdgRTAEPRRPLAVVLAPTRELAQQVADSLEPYARSV--GVRTAT 164
Cdd:cd17923     5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPILE----ALLRDPGSRALYLYPTKALAQDQLRSLRELLEQLglGIRVAT 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 165 VVGGMPIHRQARSLRQGVHLVVATPGRLRDLM----ERGDCVLDRVESAVLDEA 214
Cdd:cd17923    81 YDGDTPREERRAIIRNPPRILLTNPDMLHYALlphhDRWARFLRNLRYVVLDEA 134
DEXHc_RecQ cd17920
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ...
69-264 1.06e-06

DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.


Pssm-ID: 350678 [Multi-domain]  Cd Length: 200  Bit Score: 49.07  E-value: 1.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  69 EALKRTLarqGLTTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAFGL-ALLAGmdgrtaeprrPLAVVLAPTRELAQ-Q 146
Cdd:cd17920     2 QILKEVF---GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLpALLLD----------GVTLVVSPLISLMQdQ 68
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 147 VaDSLepyaRSVGVRTATVVGGMPIHRQ----ARSLRQGVHLVVATPGRLR--DLME--RGDCVLDRVESAVLDEA---- 214
Cdd:cd17920    69 V-DRL----QQLGIRAAALNSTLSPEEKrevlLRIKNGQYKLLYVTPERLLspDFLEllQRLPERKRLALIVVDEAhcvs 143
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1110512917 215 ----DQMTDMGFMPQVTAILQEVPaggrRMLFSATLDRNV--DTLVRRFLNDPVVH 264
Cdd:cd17920   144 qwghDFRPDYLRLGRLRRALPGVP----ILALTATATPEVreDILKRLGLRNPVIF 195
DEXHc_HFM1 cd18023
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ...
106-198 1.97e-06

DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350781 [Multi-domain]  Cd Length: 206  Bit Score: 48.12  E-value: 1.97e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLAFGLALLAGMDGRTAEPR-RPLAVVLAPTRELAQQVADSLEPYARSVGVRTATVVGgmpiHRQARSLR--QGV 182
Cdd:cd18023    26 TGSGKTVLFELAILRLLKERNPLPWgNRKVVYIAPIKALCSEKYDDWKEKFGPLGLSCAELTG----DTEMDDTFeiQDA 101
                          90
                  ....*....|....*.
gi 1110512917 183 HLVVATPGRLrDLMER 198
Cdd:cd18023   102 DIILTTPEKW-DSMTR 116
SF2_C_Hrq cd18797
C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role ...
278-396 8.65e-06

C-terminal helicase domain of HrQ family helicases; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. HrQ family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350184 [Multi-domain]  Cd Length: 146  Bit Score: 45.33  E-value: 8.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 278 HHVVHVSP---------AEKKAVATRIAA---REG-RVIMFLDTKRAVDRMAEHLLASGVLAAPL-------HGGRSQPQ 337
Cdd:cd18797     1 HFVLWNPPlldrkdgerGSARREAARLFAdlvRAGvKTIVFCRSRKLAELLLRYLKARLVEEGPLaskvasyRAGYLAED 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1110512917 338 RTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGES 396
Cdd:cd18797    81 RREIEAELFNGELLGVVATNALELGIDIGGLDAVVLAGYPGSLASLWQQAGRAGRRGKD 139
SF2_C cd18785
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ...
351-402 1.08e-05

C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350172 [Multi-domain]  Cd Length: 77  Bit Score: 43.08  E-value: 1.08e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1110512917 351 TALIATNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGESGNVVTL 402
Cdd:cd18785    24 EILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGEVIL 75
SF2_C_LHR cd18796
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ...
282-396 2.28e-05

C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350183 [Multi-domain]  Cd Length: 150  Bit Score: 44.18  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 282 HVSPAEKKAVATRIAAREGRVImFLDTKRAVDRMAEHLLA-----SGVLAAPLHGG-RSQPQRTRTLDQFKRGDVTALIA 355
Cdd:cd18796    22 ESGADAYAEVIFLLERHKSTLV-FTNTRSQAERLAQRLRElcpdrVPPDFIALHHGsLSRELREEVEAALKRGDLKVVVA 100
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1110512917 356 TNVAARGIHVDGLDLVVNIDPPTDHKDYLHRGGRTARAGES 396
Cdd:cd18796   101 TSSLELGIDIGDVDLVIQIGSPKSVARLLQRLGRSGHRPGA 141
Lhr COG1201
Lhr-like helicase [Replication, recombination and repair];
81-377 9.45e-05

Lhr-like helicase [Replication, recombination and repair];


Pssm-ID: 440814 [Multi-domain]  Cd Length: 850  Bit Score: 44.71  E-value: 9.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  81 TTPSEIQAATLPNSLAGRDVLGRSRTGSGKTLAfglALLAGMD-----GRTAEPRRPLAVV----------------LAP 139
Cdd:COG1201    23 GAPTPPQREAWPAIAAGESTLLIAPTGSGKTLA---AFLPALDelarrPRPGELPDGLRVLyisplkalandiernlRAP 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 140 TRELAQQVADSLEPYarSVGVRTatvvGGMPIHRQARSLRQGVHLVVATPGRLRdLM---ERGDCVLDRVESAVLDE--- 213
Cdd:COG1201   100 LEEIGEAAGLPLPEI--RVGVRT----GDTPASERQRQRRRPPHILITTPESLA-LLltsPDARELLRGVRTVIVDEiha 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 214 ------ADQMtdmgfmpQVT-AILQE-VPAGGRRMLFSATLdRNVDTlVRRFL----NDPVVHSVDLSEGA--------- 272
Cdd:COG1201   173 lagskrGVHL-------ALSlERLRAlAPRPLQRIGLSATV-GPLEE-VARFLvgyeDPRPVTIVDAGAGKkpdlevlvp 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 273 VSTMEHHVV---HVSPAEKKAVATRIaaREGR-VIMFLDTKRAVDRMAEHLLA----SGVLAAPLHGGRSQPQRTRTLDQ 344
Cdd:COG1201   244 VEDLIERFPwagHLWPHLYPRVLDLI--EAHRtTLVFTNTRSQAERLFQRLNElnpeDALPIAAHHGSLSREQRLEVEEA 321
                         330       340       350
                  ....*....|....*....|....*....|...
gi 1110512917 345 FKRGDVTALIATNVAARGIHVDGLDLVVNIDPP 377
Cdd:COG1201   322 LKAGELRAVVATSSLELGIDIGDVDLVIQVGSP 354
DEXHc_LHR-like cd17922
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ...
97-213 1.24e-04

DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350680 [Multi-domain]  Cd Length: 166  Bit Score: 42.19  E-value: 1.24e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  97 GRDVLGRSRTGSGKTLAfglALLAGMDGRTAEPRRPLAVV-LAPTRELAQQVADSLEPYAR------SVGVRTatvvGGM 169
Cdd:cd17922     1 GRNVLIAAPTGSGKTEA---AFLPALSSLADEPEKGVQVLyISPLKALINDQERRLEEPLDeidleiPVAVRH----GDT 73
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1110512917 170 PIHRQARSLRQGVHLVVATPGRLRDLM--ERGDCVLDRVESAVLDE 213
Cdd:cd17922    74 SQSEKAKQLKNPPGILITTPESLELLLvnKKLRELFAGLRYVVVDE 119
PRK11664 PRK11664
ATP-dependent RNA helicase HrpB; Provisional
106-372 1.71e-04

ATP-dependent RNA helicase HrpB; Provisional


Pssm-ID: 236950 [Multi-domain]  Cd Length: 812  Bit Score: 43.76  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLAFGLALL--AGMDGRTA--EPRRplavvLApTRELAQQVADSL-EPYARSVG--VRTATVVGgmpihRQARsl 178
Cdd:PRK11664   29 TGAGKSTWLPLQLLqhGGINGKIImlEPRR-----LA-ARNVAQRLAEQLgEKPGETVGyrMRAESKVG-----PNTR-- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 179 rqgvhLVVATPGRLRDLMERgDCVLDRVESAVLDE-------ADQmtdmgfmpqVTAILQEVPAGGR---RML-FSATLD 247
Cdd:PRK11664   96 -----LEVVTEGILTRMIQR-DPELSGVGLVILDEfherslqADL---------ALALLLDVQQGLRddlKLLiMSATLD 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 248 RnvDTLVRRFLNDPVVhsvdLSEGAVSTMEHHVVHVSPAEK--KAVATRIA----AREGRVIMFLDTKRAVDRMAEHL-- 319
Cdd:PRK11664  161 N--DRLQQLLPDAPVI----VSEGRSFPVERRYQPLPAHQRfdEAVARATAellrQESGSLLLFLPGVGEIQRVQEQLas 234
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1110512917 320 -LASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNVAARGIHVDGLDLVV 372
Cdd:PRK11664  235 rVASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVV 288
DEXHc_dicer cd18034
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ...
106-214 2.04e-04

DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350792 [Multi-domain]  Cd Length: 200  Bit Score: 42.25  E-value: 2.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 106 TGSGKTLafgLALLA----GMDGRTAEPRRPLAVVLAPTRELAQQVADSLEPYarsVGVRTATVVGGMPIHRQARSLRQG 181
Cdd:cd18034    25 TGSGKTL---IAVMLikemGELNRKEKNPKKRAVFLVPTVPLVAQQAEAIRSH---TDLKVGEYSGEMGVDKWTKERWKE 98
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1110512917 182 V----HLVVATPGRLRDLMERGDCVLDRVESAVLDEA 214
Cdd:cd18034    99 ElekyDVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
COG1202 COG1202
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
277-366 4.43e-04

Superfamily II helicase, archaea-specific [Replication, recombination and repair];


Pssm-ID: 440815 [Multi-domain]  Cd Length: 790  Bit Score: 42.57  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 277 EHHVVHVSPAEKKAVATRIAARE----------GRVIMFLDTKRAVDRMAEHLlasGVLAAPLHGGRSQPQRTRTLDQFK 346
Cdd:COG1202   395 ERHLTFADGREKIRIINKLVKREfdtksskgyrGQTIIFTNSRRRCHEIARAL---GYKAAPYHAGLDYGERKKVERRFA 471
                          90       100
                  ....*....|....*....|
gi 1110512917 347 RGDVTALIATnvAARGIHVD 366
Cdd:COG1202   472 DQELAAVVTT--AALAAGVD 489
HepA COG0553
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ...
294-377 1.18e-03

Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];


Pssm-ID: 440319 [Multi-domain]  Cd Length: 682  Bit Score: 40.98  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 294 RIAAREGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTA--LIATNVAARGIHVDGLDLV 371
Cdd:COG0553   544 ELLAEGEKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPvfLISLKAGGEGLNLTAADHV 623

                  ....*.
gi 1110512917 372 VNIDPP 377
Cdd:COG0553   624 IHYDLW 629
SF2_C_RecQ cd18794
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ...
298-395 1.53e-03

C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.


Pssm-ID: 350181 [Multi-domain]  Cd Length: 134  Bit Score: 38.34  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917 298 REGRVIMFLDTKRAVDRMAEHLLASGVLAAPLHGGRSQPQRTRTLDQFKRGDVTALIATNvaARGIHVDGLD--LVVNID 375
Cdd:cd18794    29 LGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATV--AFGMGIDKPDvrFVIHYS 106
                          90       100
                  ....*....|....*....|
gi 1110512917 376 PPTDHKDYLHRGGRTARAGE 395
Cdd:cd18794   107 LPKSMESYYQESGRAGRDGL 126
DDXDc_reverse_gyrase cd17924
DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of ...
96-198 5.72e-03

DDXD-box helicase domain of reverse gyrase; Reverse gyrase modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. Reverse gyrase belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.


Pssm-ID: 350682 [Multi-domain]  Cd Length: 189  Bit Score: 37.69  E-value: 5.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1110512917  96 AGRDVLGRS-----RTGSGKTlAFGL--ALLAGMDGRtaeprRPLAVVlaPTRELAQQVADSLEPYARSVGVRTATVV-- 166
Cdd:cd17924    26 AKRLLRGKSfaiiaPTGVGKT-TFGLatSLYLASKGK-----RSYLIF--PTKSLVKQAYERLSKYAEKAGVEVKILVyh 97
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1110512917 167 GGMPIHRQARSLRQ----GVHLVVATPGRLRDLMER 198
Cdd:cd17924    98 SRLKKKEKEELLEKiekgDFDILVTTNQFLSKNFDL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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