NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1109490503|gb|APG32397|]
View 

NADH dehydrogenase subunit 2 (mitochondrion) [Equus ovodovi]

Protein Classification

NADH dehydrogenase subunit 2( domain architecture ID 11475899)

NADH dehydrogenase subunit 2 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 3.78e-176

NADH dehydrogenase subunit 2; Provisional


:

Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 492.05  E-value: 3.78e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00105    1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00105   81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00105  161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFE-A 319
Cdd:MTH00105  241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFEnT 320

                         330       340
                  ....*....|....*....|....*..
gi 1109490503 320 KQITLLPPLIVASSLLLPLTPMLSILD 346
Cdd:MTH00105  321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 3.78e-176

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 492.05  E-value: 3.78e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00105    1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00105   81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00105  161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFE-A 319
Cdd:MTH00105  241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFEnT 320

                         330       340
                  ....*....|....*....|....*..
gi 1109490503 320 KQITLLPPLIVASSLLLPLTPMLSILD 346
Cdd:MTH00105  321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-296 1.32e-26

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 109.44  E-value: 1.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATAS--MLLMMAII------INL 78
Cdd:COG1007   106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSgfLLYGISLLygatgsLNL 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  79 MHSGQWTITKIFNPTASII----MTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMS----ILYQISPSIN 150
Cdd:COG1007   186 AGIAAALAAGGANSPLLLLglvlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPGLA 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 151 ---LNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTL----TMLNMLIYIMMTLTMFMLFIHSS 223
Cdd:COG1007   266 adwQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLLS 345

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109490503 224 STTTLSLSH-----TWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:COG1007   346 RKGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRV 423
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-278 5.97e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 99.31  E-value: 5.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  23 SSHWLMIWIGFEMNLLAIIP-ILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKIFNPT-------- 93
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALtgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  94 ---ASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILL-TWQKLAP-----MSILYQISPSINLNILLTMAVLSILV 164
Cdd:pfam00361  81 lllLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 165 GGWGGLNQTQLRKIMAYSSIAHMGWMMAVLA----YNPTLTMLNMLIYIMMTLTMFMLFIHSSST-----TTLSLSHTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSVIYRrvhtrNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1109490503 236 KTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIIL 278
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFL 283
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-296 2.04e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 94.63  E-value: 2.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   6 LTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATASMLLMMAI---------- 74
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgsl 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  75 -IINLMHS-GQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSI--- 149
Cdd:TIGR01770 184 nFEDLLLFlSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 150 ----NLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMfMLFIHSSST 225
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALM-SLGAFGVLS 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 226 TTLSLSHTWNKTP-----------LTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYM 294
Cdd:TIGR01770 343 LLRSYKDEWIEYIsdfaglfktnpILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYL 422


                  ..
gi 1109490503 295 RL 296
Cdd:TIGR01770 423 RV 424
 
Name Accession Description Interval E-value
ND2 MTH00105
NADH dehydrogenase subunit 2; Provisional
 1-346 3.78e-176

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177167 [Multi-domain]  Cd Length: 347  Bit Score: 492.05  E-value: 3.78e-176
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00105    1 MNPLILIIIYLTLFLGTMITMISSHWLLAWIGLEMNMLAIIPILMKKHNPRSTEAATKYFLTQATASMLLMMAIIINLMY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00105   81 SGQWTITKLTNPTASTLMTIALAMKLGLAPFHFWVPEVTQGIPLSSGMILLTWQKLAPLSILYQISPSINPNLLLTLAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00105  161 SILIGGWGGLNQTQLRKILAYSSIAHMGWMTAILPYNPTLTLLNLLIYIIMTLTMFMLLMLNSSTTTLSLSHTWNKTPLM 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFE-A 319
Cdd:MTH00105  241 TSLILLTLLSLGGLPPLTGFMPKWMIIQELTKNNNIILPTLMAITALLNLYFYMRLIYSTSLTMFPSTNNMKMKWQFEnT 320

                         330       340
                  ....*....|....*....|....*..
gi 1109490503 320 KQITLLPPLIVASSLLLPLTPMLSILD 346
Cdd:MTH00105  321 KPMTLLPTLIILSTMLLPLTPMLSILE 347
ND2 MTH00135
NADH dehydrogenase subunit 2; Provisional
 1-345 1.41e-130

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177193 [Multi-domain]  Cd Length: 347  Bit Score: 376.84  E-value: 1.41e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00135    1 MNPYVLTILLFSLGLGTTLTFASSHWLLAWMGLEINTLAIIPLMAQHHHPRAVEATTKYFLTQATAAAMILFASTTNAWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSiNLNILLTMAVL 160
Cdd:MTH00135   81 TGQWDIQQMSHPLPTTMITLALALKIGLAPLHFWLPEVLQGLDLTTGLILSTWQKLAPFALILQIAPT-NPTLLITLGLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00135  160 STLVGGWGGLNQTQLRKILAYSSIAHLGWMILVLQFSPSLTLLALLTYIIMTSSAFLTFKLNSSTKINTLATSWTKAPAL 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFEAK 320
Cdd:MTH00135  240 TALTPLILLSLGGLPPLTGFMPKWLILQELTKQDLPLTATLAALSALLSLYFYLRLSYAMTLTISPNTLNGTTPWRLPST 319

                         330       340
                  ....*....|....*....|....*.
gi 1109490503 321 QITL-LPPLIVASSLLLPLTPMLSIL 345
Cdd:MTH00135  320 QLTLpLAISTTATLMLLPLTPAILAL 345
ND2 MTH00112
NADH dehydrogenase subunit 2; Provisional
 1-342 1.52e-123

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214423 [Multi-domain]  Cd Length: 346  Bit Score: 358.75  E-value: 1.52e-123
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00112    1 MNPHAKLIITTSLILGTIITISSNHWLMAWTGLEINTLAIIPLISKPHHPRATEAATKYFLTQAAASALILFSSTTNAWN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00112   81 TGQWDITQLTNPTSCTLLTLALAMKLGLAPFHFWLPEVLQGSTTTTALILSTWQKLAPLTLLLMTSNSLNPTLLLTLAIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00112  161 STLIGGWGGLNQTQLRKIMAFSSIAHLGWMIAIITYSPKLTLLTFYIYILMTTPMFLTLNTTSTKTLKDMMTSWTKSPTL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFEAK 320
Cdd:MTH00112  241 NTTLMLTLLSLAGLPPLTGFMPKWLILQELTKQNMTPTATIMAMLSLLSLFFYLRLTYISTITLPPNTTNMMMKWRTKPK 320

                         330       340
                  ....*....|....*....|..
gi 1109490503 321 QITLLPPLIVASSLLLPLTPML 342
Cdd:MTH00112  321 KNTLTATLTTLSTLLLPLSPMI 342
ND2 MTH00070
NADH dehydrogenase subunit 2; Provisional
 1-342 2.07e-117

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177142 [Multi-domain]  Cd Length: 346  Bit Score: 343.06  E-value: 2.07e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00070    1 MSPYALSILLSSLALGTMITLSSNHWFLAWMGLEINTLAIIPLMTKTHHPRATEAATKYFLTQASASALILFSSTINAWF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00070   81 TGEWTIMNMQTPLPTIMLTIALMMKLGIAPFHFWLPEVLQGLDLTTGLILSTWQKLAPMALLIQISHLLNSNLLIIMGLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00070  161 STLIGGWGGLNQTQLRKIMAYSSIAHLGWMIIILTFSPHLTLLNLLIYLIMTSSMFLMLMNLNSTNINKLSSSWSKNPTL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFEAK 320
Cdd:MTH00070  241 TSMMMLTLLSLGGLPPTTGFIPKWLILQELTKQNLTTLATLMALSALLSLFFYLRLSYAMSLTTSPNTSNSKLYWRFKNK 320

                         330       340
                  ....*....|....*....|..
gi 1109490503 321 QITLLPPLIVASSLLLPLTPML 342
Cdd:MTH00070  321 TNNLLSLTIILSLMLLPITPTI 342
ND2 MTH00041
NADH dehydrogenase subunit 2; Validated
 1-306 2.42e-88

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 177116 [Multi-domain]  Cd Length: 349  Bit Score: 269.11  E-value: 2.42e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00041    1 MNRNVLIFLITSIILGTIIVISSNHWFLIWLGLELNTLSIIPILSSNFSPRSVEATIKYFLVQAFSAAILLNGALIQAWL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00041   81 SGSWSINGPLNTLSSIIITLALALKLGLAPCHFWFPDVLQGLPFLQGLIIATWQKIAPLILLISISNLLNSNILILCGIL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00041  161 SVLVGGWGGLNQTQTRKILAFSSIAHLGWIIITSAYSPNASIIMFLIYIIINTSIFLIGNNFSLSTLSHLNKLSQLNPIS 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFP 306
Cdd:MTH00041  241 AFLFILSILSLGGLPPLTGFLNKFISLYCLIQNNSILISIILIIGSLLSLFFYLRISFNTSLTLFP 306
ND2 MTH00200
NADH dehydrogenase subunit 2; Provisional
 1-345 1.25e-84

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177246 [Multi-domain]  Cd Length: 347  Bit Score: 259.52  E-value: 1.25e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMH 80
Cdd:MTH00200    1 MSPLILPLFILSLGLGTLLTFSSSHWFLIWLGLEINTLAIIPLLIKQHHPRKVEATTKYFIIQATASALLLFGGLLNAWT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 SGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVL 160
Cdd:MTH00200   81 SGQWGISEMLGPLSETLILLALALKLGLAPGHFWVPDVLQGLSLQTGLILSTWQKLAPFALLIQLAPALNSNILLLLGLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00200  161 SVLVGGWGGLNQTQLRKILAYSSIAHLGWLLSGLVYSPNLALLYLLLYVIITLTVFLLLNLLNSTKINSLSSSKTKNPIL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQFEAK 320
Cdd:MTH00200  241 SMLLGLTLLSLGGLPPLTGFFPKWLILQELSKQGLFIYATILLLGSLLSLFFYLRLSYLTLLTLSPNQINMMSSWRTKSN 320

                         330       340
                  ....*....|....*....|....*
gi 1109490503 321 QITLLPPLIVASSLLLPLTPMLSIL 345
Cdd:MTH00200  321 SNLLVGLLLLLSILGLPLTPQLLFL 345
ND2 MTH00160
NADH dehydrogenase subunit 2; Provisional
 1-314 3.87e-53

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214442 [Multi-domain]  Cd Length: 335  Bit Score: 178.09  E-value: 3.87e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMh 80
Cdd:MTH00160    2 MMNSSKLLFLSTLIMGTLISISSNSWFGAWMGLEINLLSFIPLISNKKNLMSSESSLKYFLIQALASIILLFSIILNML- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  81 sgqwtITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQIspsINLNILLTMAVL 160
Cdd:MTH00160   81 -----NLMLFNNISSMLINSSLLLKLGAAPFHFWFPEVMEGLSWINCFILMTWQKIAPLILLSYL---INNNFIIIIIIL 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 161 SILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLT 240
Cdd:MTH00160  153 SAIIGAIGGLNQTSLRKILAYSSINHLGWMLSSMMISENLWLIYFLIYSIISLSIILLFNKFNIFFLNQLFNSNNKSKKI 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109490503 241 TTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMK 314
Cdd:MTH00160  233 KFLLFLNLLSLGGLPPFLGFLPKWIIIQLLISNNMFFLLFILIMSSLITLYFYLRISYSSLMLNYNKNKWNLKK 306
ND2 MTH00144
NADH dehydrogenase subunit 2; Provisional
 10-315 5.21e-50

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214432 [Multi-domain]  Cd Length: 328  Bit Score: 169.68  E-value: 5.21e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  10 LMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTItki 89
Cdd:MTH00144   10 LFLMVMGTLLSLSSSHWLGVWVGLEINLIGFLPLLVYKKKSSESESVVKYFIIQSLGSSLLIFGSLIMYNLSFSWFS--- 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  90 fnptaSIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINL-NILLTMAVLSILVGGWG 168
Cdd:MTH00144   87 -----MSLLLLGLCLKLGLFPFHFWVPSVMAGLSWLSCFLLLTWQKVAPLFLLSNFLDLYWLaYLLCVISVLSALVGSIG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 169 GLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTwNKTPLTTTLILITL 248
Cdd:MTH00144  162 GLNQTQVRALLAYSSISHTGWMLVAILHGSWLMWMYFLIYIVSSGFLFFSLWSGDSGSMKDLGSL-KPSYKTGLSIISLL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1109490503 249 LSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKW 315
Cdd:MTH00144  241 LSLGGLPPFLGFCSKLLVLISSMESSPLLLILLLLLGSLISLFFYLSVFFSSFLSSSKSKKSNSSKV 307
ND2 MTH00011
NADH dehydrogenase subunit 2; Validated
 12-299 4.89e-45

NADH dehydrogenase subunit 2; Validated


Pssm-ID: 164587 [Multi-domain]  Cd Length: 330  Bit Score: 156.86  E-value: 4.89e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  12 TVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQwtitkIFN 91
Cdd:MTH00011   14 TMTLGTLMALSSNNWLFLWMGMELNLLSFVPLMTSSKMNQESEAAVKYFLAQALGSGLLLLGMTMMWSFPSL-----LKN 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  92 PTASIIMTSaLAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVLSILVGGWGGLN 171
Cdd:MTH00011   89 ITALMLLVS-LMLKLGMAPCHFWFPSVMSSISWTLCLILSTWQKIAPLSILFFFTSHNILPMMTSMAAMSALAGGLGGMN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 172 QTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLTTTLILITLLSM 251
Cdd:MTH00011  168 QTQLRPLLAYSSIGHMGWMTMISVFSPSMAILYFMTYIIITTPLMLLFAYLNAFSTKFNSKISSMSQTTSMSLFIMLLSL 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1109490503 252 GGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYS 299
Cdd:MTH00011  248 GGLPPFTGFMPKLMAIETLTSNSMILILLVLIVGSLMNLFYYLNLIFN 295
ND2 MTH00197
NADH dehydrogenase subunit 2; Provisional
 8-300 2.38e-38

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177244 [Multi-domain]  Cd Length: 323  Bit Score: 139.04  E-value: 2.38e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSgqwtit 87
Cdd:MTH00197    2 LFLFIIFGGVLFSLSSSNWFLVWIGMELNLIGFIPLLSQNKSITENEGAMKYFLFQEFGSALLLMGGSLSFSNL------ 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  88 kIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPsiNLNILLTMAVLSILVGGW 167
Cdd:MTH00197   76 -YLSLLSVVLVILGLLLKLGAFPFHFWVPSVMESLSWFNCFLLATWQKLAPLLILAFNSS--SFMGLLICSVLSSLIGGI 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 168 GGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWNKTPLTTTLILIT 247
Cdd:MTH00197  153 GGMNQSNIRQLLAYSSIGHTGWMLMSLVYSPSIFMLYYLIYFVIMFMLFLFLSKNNLSSLNQQYSNPESMSSNLVFLGLS 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1109490503 248 LLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYST 300
Cdd:MTH00197  233 FLSLGGLPPLSGFFLKWLILTSLLSSNISLITFMLILSTCFSLYYYLSLAYKS 285
ND2 MTH00199
NADH dehydrogenase subunit 2; Provisional
 8-296 5.83e-27

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177245 [Multi-domain]  Cd Length: 460  Bit Score: 110.49  E-value: 5.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEM-NLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTI 86
Cdd:MTH00199  101 ILILIVALGSLLLVSSINWLSIYLAIELqTLTLFILVALKRDSAYSTEAGLKYFVLGAVSSGLFLFGCALLYGLTGETSI 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  87 TKI----FNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINlnILLTMAVLSI 162
Cdd:MTH00199  181 QGInsilTGDVGKILITISLLFKLSAAPFHMWAPDVYEGAPTITTALLATVPKIGVFSILVQIGPVTN--VVLICAVLSI 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 163 LVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNP----TLTMLNMLIYIMMTLTMF--MLFIHSSSTTTLSLSHTWNK 236
Cdd:MTH00199  259 IYGAIGALNQTKIKRLLAYSGIGHMGFILFGVAIGSfesiQASLIYMIIYVIMSICSFsiILSLKLTKGLIVEVSGLSRK 338

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 237 TPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:MTH00199  339 NPVIALTLALTFLSIAGIPPLAGFLSKWLILLSGVSSGYYLICIIAVLSSVIAGVYYVRV 398
NuoN COG1007
NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH: ...
 8-296 1.32e-26

NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 2 (chain N) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440631 [Multi-domain]  Cd Length: 473  Bit Score: 109.44  E-value: 1.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATAS--MLLMMAII------INL 78
Cdd:COG1007   106 ALLLFATLGMMLMASANDLLTLFLGLELLSLSLyVLVAFRRDDRRSSEAALKYFLLGALSSgfLLYGISLLygatgsLNL 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  79 MHSGQWTITKIFNPTASII----MTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMS----ILYQISPSIN 150
Cdd:COG1007   186 AGIAAALAAGGANSPLLLLglvlVLAGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAallrLLVEAFPGLA 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 151 ---LNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTL----TMLNMLIYIMMTLTMFMLFIHSS 223
Cdd:COG1007   266 adwQLLLAVLAVLSMTVGNLAALAQTNVKRMLAYSSIAHAGYLLLGLAAGTPLgvsaALFYLLAYLFMNLGAFAVILLLS 345

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1109490503 224 STTTLSLSH-----TWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:COG1007   346 RKGGEAEEIedlagLARRSPLLALAMTIFLLSLAGIPPTAGFFGKFYVFSAAVEAGLYWLAVIAVLNSVISAYYYLRV 423
ND2 MTH00196
NADH dehydrogenase subunit 2; Provisional
 13-296 1.33e-26

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214453 [Multi-domain]  Cd Length: 365  Bit Score: 108.19  E-value: 1.33e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  13 VFLGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATASMLLMMAI-------------IINL 78
Cdd:MTH00196    2 VALGILCLISSSNWLSVYLAIELQTLSLfILIAQNRGSGYSAEAGLKYFVLGALSSGLFLFGCallcgttgglhlsYINL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  79 MHSGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPsiNLNILLTMA 158
Cdd:MTH00196   82 VLNSGQSFSSVSVPIGYLLIIVALLFKLSVAPFHMWAPDVYEGAPTKTTALLAIVPKLGIFSILVSIGL--NVNILLIGG 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 159 VLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNP----TLTMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSH-- 232
Cdd:MTH00196  160 LFSLFVGAIGALNQTKIKRLLAYSGIGHMGFVLWGIEIGSfesiQASLVYLFIYIIMSICVFSIILALNVYKNLIIEFsg 239

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1109490503 233 TWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:MTH00196  240 LSRRLPILAITLALTFLSIAGIPPLVGFLGKWLILLSGVVYQYYLIFLLAVFCSVIAGVYYVRI 303
Proton_antipo_M pfam00361
Proton-conducting membrane transporter; This is a family of membrane transporters that ...
 23-278 5.97e-24

Proton-conducting membrane transporter; This is a family of membrane transporters that inlcudes some 7 of potentially 14-16 TM regions. In many instances the family forms part of complex I that catalyzes the transfer of two electrons from NADH to ubiquinone in a reaction that is associated with proton translocation across the membrane, and in this context is a combination predominantly of subunits 2, 4, 5, 14, L, M and N. In many bacterial species these proteins are probable stand-alone transporters not coupled with oxidoreduction. The family in total represents homologs across the phyla.


Pssm-ID: 425636 [Multi-domain]  Cd Length: 291  Bit Score: 99.31  E-value: 5.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  23 SSHWLMIWIGFEMNLLAIIP-ILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKIFNPT-------- 93
Cdd:pfam00361   1 ANDLLLMYLGWEAVLLPSYLlIGYWGKSPRSSEAGMKYFLLTLLGSSILLFGISLMYNYTGTLSFDELSKALtgglnssg 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  94 ---ASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILL-TWQKLAP-----MSILYQISPSINLNILLTMAVLSILV 164
Cdd:pfam00361  81 lllLFLLILVGFLFKSAQVPFHTWLPDAYEGAPTPVSALLAaTLVKAGGyglirRSLLYLPSSPFIQQILLILAIISMLL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 165 GGWGGLNQTQLRKIMAYSSIAHMGWMMAVLA----YNPTLTMLNMLIYIMMTLTMFMLFIHSSST-----TTLSLSHTWN 235
Cdd:pfam00361 161 GSLAALVQTDIKRLLAYSSISHMGYMLIALGagtiYGIQAAIFHLLTHGLFSAGLFLCAGSVIYRrvhtrNIRDYGGLAK 240

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1109490503 236 KTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIIL 278
Cdd:pfam00361 241 TMPILALVFLVAMLSLAGLPPTAGFLGKFLILAAAVAASWIFL 283
NDH_I_N TIGR01770
proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th ...
 6-296 2.04e-21

proton-translocating NADH-quinone oxidoreductase, chain N; This model describes the 14th (based on E. coli) structural gene, N, of bacterial and chloroplast energy-transducing NADH (or NADPH) dehydrogenases. This model does not describe any subunit of the mitochondrial complex I (for which the subunit composition is very different), nor NADH dehydrogenases that are not coupled to ion transport. The Enzyme Commission designation 1.6.5.3, for NADH dehydrogenase (ubiquinone), is applied broadly, perhaps unfortunately, even if the quinone is menaquinone (Thermus, Mycobacterium) or plastoquinone (chloroplast). For chloroplast members, the name NADH-plastoquinone oxidoreductase is used for the complex and this protein is designated as subunit 2 or B. This model also includes a subunit of a related complex in the archaeal methanogen, Methanosarcina mazei, in which F420H2 replaces NADH and 2-hydroxyphenazine replaces the quinone. [Energy metabolism, Electron transport]


Pssm-ID: 273795 [Multi-domain]  Cd Length: 468  Bit Score: 94.63  E-value: 2.04e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   6 LTIILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATASMLLMMAI---------- 74
Cdd:TIGR01770 104 FYILLLFALLGIFLLVSSNDLLSIYLGLELQSLCFyVLAGLKRKSRFSTEAGLKYFILGAFSSGLLLFGIsliygftgsl 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  75 -IINLMHS-GQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSI--- 149
Cdd:TIGR01770 184 nFEDLLLFlSNGMLNISLLLLGIVLILVGLLFKLSAVPFHMWVPDVYEGAPTPVTAFFSIVPKIAIFAVFLRLFLYIlfg 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 150 ----NLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMMTLTMfMLFIHSSST 225
Cdd:TIGR01770 264 fseaWQIFLAIIAFLSMLIGNFGALAQKKVKRLLAYSSISHVGYILIGLLAGTLEGIKAVLFYIFIYALM-SLGAFGVLS 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 226 TTLSLSHTWNKTP-----------LTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYM 294
Cdd:TIGR01770 343 LLRSYKDEWIEYIsdfaglfktnpILAILILIFMFSLAGIPPLAGFFGKFYVFFALLKSGLYWLAVIAVLTSVIGAFYYL 422


                  ..
gi 1109490503 295 RL 296
Cdd:TIGR01770 423 RV 424
PRK05777 PRK05777
NADH-quinone oxidoreductase subunit NuoN;
15-296 1.47e-20

NADH-quinone oxidoreductase subunit NuoN;


Pssm-ID: 235603 [Multi-domain]  Cd Length: 476  Bit Score: 92.19  E-value: 1.47e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  15 LGTMIVMMSSHWLMIWIGFEMNLLAI-IPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKIFNPT 93
Cdd:PRK05777  114 LGMMVMVSANDLLTLFLGLELLSLPLyALAALRRDRRRSLEAAIKYFVLGALASGFLLYGMSLLYGATGSLSFAGIAKAL 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  94 AS------------IIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQI-------SPSINLNIL 154
Cdd:PRK05777  194 ADgsgnsllllfglVFLLVGLAFKLSAVPFHMWTPDVYEGAPTPVTAFLATAPKIAAFAVLLRLlvvafggLSEDWQQVL 273

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 155 LTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTL----TMLNMLIYIMMTLTMF-MLFIHSSSTTTLS 229
Cdd:PRK05777  274 AIIAIASMLVGNLAALSQTNIKRLLAYSSIAHAGYLLVGLAAGTAEgysaVLFYLLAYLFMTLGAFgVISLLRRKGGEAE 353

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1109490503 230 LSHTWN----KTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:PRK05777  354 SISDFAglskRSPLLAAVMTIFMLSLAGIPPTAGFWGKFYVFEAAVEAGLWWLAVIGVLNSAIGAFYYLRV 424
HyfB COG0651
Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy ...
 10-296 2.53e-18

Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 440416 [Multi-domain]  Cd Length: 430  Bit Score: 85.20  E-value: 2.53e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  10 LMTVFLGTMI-VMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITK 88
Cdd:COG0651   112 LFLLLLAGMNgAFLTGDLFNLFVFFEVMLLASYGLVALGGTKEALRAGLKYLILNLVGSALFLLGVGLLYGATGTLNMAD 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  89 IFN----------PTASIIMTSALAMKLGLTPFHFWVPE-----------VTQGISLTSGL--ILLTWQKLAPMSILYQI 145
Cdd:COG0651   192 LAArlaeldpgllLAAFALLLVGFGIKAALFPLHFWLPDaypaapspvsaLLSGLLTKVGVyaILRVLTLLFGADPALFL 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 146 SPsinlnILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMM-TLTMFMLFIHSSS 224
Cdd:COG0651   272 GT-----LLLVLGLLTMLVGALGALAQRDLKRLLAYSSVSQIGYILLGLGLGTPLGLAGALFHLLNhALAKALLFLAAGA 346

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1109490503 225 TTTLSLSH-------TWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:COG0651   347 IERATGTRdldklggLGKRMPLTAAAFLIGALALAGLPPLSGFVSKWLLLQAALEAGAWLLAAVLLLSSLLTLAYFVRI 425
ND2 MTH00198
NADH dehydrogenase subunit 2; Provisional
 9-191 2.92e-11

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 214454 [Multi-domain]  Cd Length: 607  Bit Score: 64.49  E-value: 2.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   9 ILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAM---------EASTKYFLTQATASMLLMMAIIINLM 79
Cdd:MTH00198  193 LVLIVGLGGLLLIESANWLTIYLALEFQTLALFILAGEGSQPGSHfpspgntppESGLKYWILGAMSSGFYLFGCALYFG 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  80 HSGQ----WTITKIFNPTASI----------IMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILyqI 145
Cdd:MTH00198  273 FTGNegmlGTILSATLETTNIelrqgslgylFITVAILFKLAAAPFHMWTPDVYEGAPTPTTALIAIIPKFTVYILL--T 350

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1109490503 146 SPSINLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:MTH00198  351 SLVITSKLLLSVAIISLVVGAFGALNQTRIKRLLAYSGIGHIGFIL 396
PRK02504 PRK02504
NAD(P)H-quinone oxidoreductase subunit N;
9-295 1.62e-10

NAD(P)H-quinone oxidoreductase subunit N;


Pssm-ID: 235044 [Multi-domain]  Cd Length: 513  Bit Score: 61.99  E-value: 1.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   9 ILMTVFLGTMIVMMSSHWLMIWIGFEMnlLAIIPILMKKY---SPRAMEASTKYFLTQATAS-MLLMMAIIINLMHSGQW 84
Cdd:PRK02504  115 ILLTATLGGMFLSGATELVMIFISLET--LSIASYLLTGYmkrDPRSNEAALKYLLIGAASSaIFLYGSSLLYGLSGGST 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  85 TITKI-----FNPT-----ASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLA----PMSILYQISPSIN 150
Cdd:PRK02504  193 QLSAIalaliTSPSlglalALVFVIAGIAFKISAVPFHQWTPDVYEGSPTPVVAFLSVGSKAAgfalAIRLLVTAFPSFD 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 151 LN---ILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNP----TLTMLNMLIYIMMTLTMFMLFIHSS 223
Cdd:PRK02504  273 EQwklLFTALAILSMVLGNVVALAQTSMKRMLAYSSIGQAGFVMIGLVAGTeagyASMVFYLLAYLFMNLGAFACVILFS 352

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1109490503 224 STT----TLSLSHTWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMR 295
Cdd:PRK02504  353 LRTgtdqISDYAGLYQKDPLLTLGLSLCLLSLGGIPPLAGFFGKIYLFWAGWQAGLYLLVLVGLVTSVISIYYYIR 428
NADH_dehy_S2_C pfam06444
NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region ...
 291-340 1.39e-09

NADH dehydrogenase subunit 2 C-terminus; This family consists of the C-terminal region specific to the eukaryotic NADH dehydrogenase subunit 2 protein and is found in conjunction with pfam00361.


Pssm-ID: 461914 [Multi-domain]  Cd Length: 51  Bit Score: 53.03  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1109490503 291 YFYMRLTYSTSLTMFPSTNNMKMKWQFEAKQ-ITLLPPLIVASSLLLPLTP 340
Cdd:pfam06444   1 FFYLRLSYSTTLTLFPNTNNSKMKWRFNSTKnTLLLPTLTTLSILLLPLTP 51
ndhB CHL00049
NADH dehydrogenase subunit 2
 8-296 2.41e-09

NADH dehydrogenase subunit 2


Pssm-ID: 176990 [Multi-domain]  Cd Length: 494  Bit Score: 58.48  E-value: 2.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEMnlLAIIPILMKKYSPRAM---EASTKYFLTQATASMLLMMAIIINLMHSGQ- 83
Cdd:CHL00049  115 LFVLTATLGGMFLCGANDLITIFVALEC--LSLCSYLLSGYTKKDVrsnEATMKYLLMGGASSSILVYGFSWLYGLSGGe 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  84 ---WTI------TKIFNPTAS----IIMTSALAMKLGLTPFHFWVPEVTQG--------ISLTS---GLILLTwqklAPM 139
Cdd:CHL00049  193 ielQEIvnglinTQMYNSPGIsialIFITVGIGFKLSLAPFHQWTPDVYEGsptpvvafLSVTSkvaASALAT----RIF 268

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 140 SILYQISPSINLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMM-AVLAYNPTL---TMLN-MLIYIMMTLT 214
Cdd:CHL00049  269 DIPFYFSSNEWHLLLEILAILSMILGNLIAITQTSMKRMLAYSSIGQIGYVIiGIIVGDSNDgyaSMITyMLFYIFMNLG 348

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 215 MFMLFIHSSSTTTLSLSH----TWNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNL 290
Cdd:CHL00049  349 TFACIVLFGLRTGTDNIRdyagLYTKDPFLALSLALCLLSLGGIPPLAGFFGKLYLFWCGWQAGLYFLVSIGLLTSVISI 428


                  ....*.
gi 1109490503 291 YFYMRL 296
Cdd:CHL00049  429 YYYLKI 434
PRK08375 PRK08375
putative monovalent cation/H+ antiporter subunit D; Reviewed
 50-298 1.45e-08

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236251 [Multi-domain]  Cd Length: 487  Bit Score: 56.04  E-value: 1.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  50 PRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWT---ITKIFNP-----TASIIMTSALAMKLGLTPFHFWVPEVTQG 121
Cdd:PRK08375  152 RRALAAARKYLIVGLIGSTFLLIGVGLLYGVTGTLNmadLAGALAEnptvvTAFGFVLLALALKAAVFPLHTWLPRAYPA 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 122 ISLTSGLILLTWQKLAPMSILYQISPSI----------NLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:PRK08375  232 APPVVTALLSGLVTKVAVYALIRIYFTVfggdfrfalgLGWLLAVLALLSMLVGSLAALGQDDVKRVLAYSTVSQMGYIL 311

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 192 AVLAYNPTLTMLNMLIYIM----MTLTMFMLFIHSSSTTTLSLSHTWNKTP----LTTTLILITLLSMGGLPPLSGFMPK 263
Cdd:PRK08375  312 LGLALLTPLALAAGLLHLLhhalMKGALFLAAGAIEVTYGTRRLSELSGLGrrmpLTAAAFAVASLSLIGVPPTSGFVSK 391

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1109490503 264 WMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTY 298
Cdd:PRK08375  392 WYLVVGAVEAGQWLVLAVLLASSLLALLYFLRIWY 426
NDH_I_M TIGR01972
proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th ...
 8-218 1.25e-07

proton-translocating NADH-quinone oxidoreductase, chain M; This model describes the 13th (based on E. coli) structural gene, M, of bacterial NADH dehydrogenase I, as well as chain 4 of the corresponding mitochondrial complex I and of the chloroplast NAD(P)H dehydrogenase complex. [Energy metabolism, Electron transport]


Pssm-ID: 273903 [Multi-domain]  Cd Length: 481  Bit Score: 53.02  E-value: 1.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   8 IILMTVFLGTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASmLLMMAIIINLMHSGQWT-- 85
Cdd:TIGR01972 110 ALLLLLEAGVIGVFLALDLFLFYVFWEAMLIPMYLLIGVWGGPNRIYAAMKFFLYTLAGS-LLMLLAILGLYFLGGGTfd 188

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  86 ----ITKIFNPTASIIMTSAL----AMKLGLTPFHFWVPEV-TQGISLTSGLILLTWQKLAP---MSILYQISPS---IN 150
Cdd:TIGR01972 189 llelLNLPLPFGVQTWLFLAFfiafAVKVPLFPLHTWLPDAhVEAPTAGSVILAGVLLKMGTygfLRFNLPLFPDaslYF 268

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1109490503 151 LNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGW-MMAVLAYNPTLT---MLNMLIYIMMTLTMFML 218
Cdd:TIGR01972 269 APVLAALGVIAIIYGALIALAQTDIKRLIAYSSISHMGFvLLGIFSFNELGIsgaVFQMISHGLITAALFLL 340
PRK08376 PRK08376
putative monovalent cation/H+ antiporter subunit D; Reviewed
 48-299 2.37e-07

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 236252 [Multi-domain]  Cd Length: 521  Bit Score: 52.41  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  48 YSPRAMEASTKYFLTQATASMLLMMAIII-----NLMHSGQWTITKIFNPT-----ASIIMTSALAMKLGLTPFHFWVPE 117
Cdd:PRK08376  166 DTWEAIEAGIKYMFVGSLASSMVLLGIALlygqyGTLNMAYLAVKMSENPTvvakiALALFIAGLAMKSGAVPVHMWLPD 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 118 VTQGI--SLTSGLILLTWQKL-APMSILYQI-SPSINLN----ILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGW 189
Cdd:PRK08376  246 AYPAApsSISAMLLVIKQAGLyALARVLFSIyGPAINLAtvgwVIIILGCLTMFVGVAMAVVQKDVKRLLAYHSVSQIGY 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 190 MM-----AVLAYNPTL------TMLNMLIYIMMTLTMFMLFIHSSSTTTLSLSHTWN---------KTPLTTTLILITLL 249
Cdd:PRK08376  326 MLlglgvGLAALGDPAmasygeIALAGGIYHIVNHALYKALLFLTAGAVIYETGTRNlnelgglarTMPKTTIAFLIGAA 405

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1109490503 250 SMGGLPPLSGFMPKWMIIQeltknSSIILPTLMAIMAL----LNLYFYMRLTYS 299
Cdd:PRK08376  406 AIVGLPPFNGFASKWLIYE-----SSALFNPILGVIAMigsvLTLASFVKVFHT 454
NuoM COG1008
NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH: ...
 49-195 2.71e-07

NADH:ubiquinone oxidoreductase subunit 4 (chain M) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 4 (chain M) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440632 [Multi-domain]  Cd Length: 488  Bit Score: 52.01  E-value: 2.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  49 SPRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTI-------TKIFNPTASIIMTS---ALAMKLGLTPFHFWVPEV 118
Cdd:COG1008   156 GERRIYAAIKFFLYTLAGSLLMLVAILALYFLAGALTFdiaelaaAPLPLTAQLLLFLAffiAFAVKVPMFPFHTWLPDA 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 119 -----TQGISLTSGLIL----------------LTWQKLAPmsilyqispsinlnILLTMAVLSILVGGWGGLNQTQLRK 177
Cdd:COG1008   236 hveapTAGSVLLAGVLLkmggygllrfalplfpEASAYFAP--------------LLAALGVIGIIYGALVALAQTDLKR 301

                         170
                  ....*....|....*...
gi 1109490503 178 IMAYSSIAHMGWMMAVLA 195
Cdd:COG1008   302 LIAYSSVSHMGFVLLGIF 319
NuoL COG1009
Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ ...
 50-300 3.20e-07

Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit [Energy production and conversion]; Membrane H+-translocase/NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440633 [Multi-domain]  Cd Length: 608  Bit Score: 52.08  E-value: 3.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  50 PRAMEASTKYFLTQATASMLLMMAIIINLMHSGQWTITKIFNPTASIIMTSAL----------AM-KLGLTPFHFWVPE- 117
Cdd:COG1009   158 PSARRAARKAFLVTRVGDLGLLLGILLLGAIAGTLNFSELLAAAPTILSSPLLtlillllllgAFgKSAQFPLHFWLPDa 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 118 ----------------VTQGISLtsglilltwqkLAPMSILYQISPSInLNILLTMAVLSILVGGWGGLNQTQLRKIMAY 181
Cdd:COG1009   238 megptpvsallhaatmVKAGVYL-----------LARLSPLFALSPVW-LTVVAIIGAITALFAALIALAQTDIKRVLAY 305

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 182 SSIAHMGWMMAVLAYNPTLTMLNML-----------------IYIMMTLTMFMLfihssstttlslSHTWNKTPLTTTLI 244
Cdd:COG1009   306 STVSQLGYMFLALGVGAYVAALFHLlthaffkallflgagsvIHATGTRDIRKM------------GGLRKKMPITAITF 373

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1109490503 245 LITLLSMGGLPPLSGFMPKWMIIQEL--TKNSSIILPTLMAIMALLNLYFYMRLTYST 300
Cdd:COG1009   374 LIGALSLAGIPPFAGFFSKEAILEAAleAGGLGPLLLAVALLGAFLTAFYSFRLFFLV 431
PRK12663 PRK12663
Na+/H+ antiporter subunit D;
92-296 7.68e-07

Na+/H+ antiporter subunit D;


Pssm-ID: 237163 [Multi-domain]  Cd Length: 497  Bit Score: 50.72  E-value: 7.68e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  92 PTASIIMTSALAMKLGLTPFhFWVPEV-----TQGISLTSGLilLT----WQKLAPMSILYQISPSINLNILLTMAVLSI 162
Cdd:PRK12663  207 TTIALLFLLAFGMKAALFPF-MWLPAAyhtpnTEVAALFAAL--LTkvgiYALIRVFTLLFPQERELLHPLLATMAAITM 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 163 LVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNpTLTMLNMLIYIMM--TLTMFMLFIHSSSTTTL-------SLSHT 233
Cdd:PRK12663  284 VIGALGALAYKDIRRIAGYQVISSIGFILLGLALG-TPAGINGAIFYLVhdMVVKTALFLIAGSLVRLtgyrslqYLGGL 362

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1109490503 234 WNKTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRL 296
Cdd:PRK12663  363 YRKEPLFGALFLILIFAIGGLPPFSGFWGKVLLVQGALDNGAYILLALMLITSLITMYSLFRI 425
PRK12667 PRK12667
putative monovalent cation/H+ antiporter subunit D; Reviewed
 47-299 4.03e-06

putative monovalent cation/H+ antiporter subunit D; Reviewed


Pssm-ID: 237167 [Multi-domain]  Cd Length: 520  Bit Score: 48.43  E-value: 4.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  47 KYSPRAMEASTKYFLTQATASMLLMMAIII-------------NLMHSGQW---TITKIFNPTASIIMTSALAM-----K 105
Cdd:PRK12667  157 RDRGDAVEAAIKYALIGAVGTTLYFLALAFlyatfgtlnmadlSAKIRGLSfplTGGLAGNPPLALGVALALALwaftiK 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 106 LGLTPFHFWVPEV-----TQGISLTSGLILLTwQKLAPMSILYQI---------SPSINLNILLTMAVLSILVGGWGGLN 171
Cdd:PRK12667  237 AAIFPNHFWLPDAhpaapSPVSAMLSGLVVNV-GAYAIIRFLYTIfgispslidFRAALSPILIILGAVSAIIGALMMVV 315

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 172 QTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIMM-TLTMFMLFIHSSSTTTLS-------LSHTWNKTPLTTTL 243
Cdd:PRK12667  316 QKDVKRLLAYSTISHMGYIFMGIGIGTQLGLAAALFHIINhAIAKSLLFLASGVFIHAAgtrdideLAGLGRKMPIASFA 395

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1109490503 244 ILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYS 299
Cdd:PRK12667  396 FLIGALSLVGIPPLNGFFSKLLLFNALLESGFYLPALVLLIASAISLVGYFRAWYS 451
PRK08668 PRK08668
NADH dehydrogenase subunit M; Validated
 10-307 2.20e-05

NADH dehydrogenase subunit M; Validated


Pssm-ID: 236332 [Multi-domain]  Cd Length: 610  Bit Score: 46.14  E-value: 2.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  10 LMTVFLGTMIVMMSSHWLMIWIGFEMNLLA--IIPILMKKYSpraMEASTKYFLTQATASMLLMMAIIINLMHSGQWTIT 87
Cdd:PRK08668  104 ALMSLAGVLGVFLANDLLTLYIFWEIMTFSsfMMVPMGKKES---RKASLKYFVLSAIGAYAMLYAIFLIYAKTGTFDFA 180

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  88 KIFNP-----------TASIIMTSALAMKLGLTPFHFWVPEV--------------------TQGISLTSGLILLTwqKL 136
Cdd:PRK08668  181 DISQGlindtstgfalIVFLFLLAFGVAKAGIFPLHVWAPDAyseapqsfsavlsgqlsklgAYGFLLVLYVLPGT--KL 258

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 137 APMSILYQISPSINLnILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLT----MLNMLIYIMMT 212
Cdd:PRK08668  259 FSEFGTYRGVPLFNY-ILAWLGNISIIVGTLMAILQEDIKKLIAYSSVANGGYILVGLGLGTSLGfaggLFHVFNHALFK 337

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 213 LTMFMLFIHSSSTTTLSLSHTWN----KTPLTTTLILITLLSMGGLPPLSGFMPKWMIIQELTKNSSIILPTLMAIMALL 288
Cdd:PRK08668  338 GLFFLIFAAVIYRTGTTKISEMGglieKMPFTFAMYLVAIISLAGIPPMSGFASKWLIFEALISKGMPITAFMAFFGSIG 417

                         330
                  ....*....|....*....
gi 1109490503 289 NLYFYMRLTYSTSLTMFPS 307
Cdd:PRK08668  418 SFLYVFRPLAGVFLGQLPS 436
PRK08676 PRK08676
hydrogenase membrane subunit; Validated
 94-210 4.89e-04

hydrogenase membrane subunit; Validated


Pssm-ID: 181537 [Multi-domain]  Cd Length: 485  Bit Score: 41.66  E-value: 4.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  94 ASIIMTSALAMKLGLTPFHFWVPEV-TQGISLTSGLILLTWQKLAPMSILY--------QISPSINlNILLTMAVLSILV 164
Cdd:PRK08676  208 SFLFIFIGFLAKSGLVPFHTWLPAAyAKAPSVVSALLSGTVLNIGIYGILRlsallrqsGAAEQFS-NVLIGLGIFSIAV 286

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1109490503 165 GGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTMLNMLIYIM 210
Cdd:PRK08676  287 AAFSMLSQRNLKKLIAFSSIEHMGLMLLGIGIGTPLALFWMLFHML 332
PRK05846 PRK05846
NADH:ubiquinone oxidoreductase subunit M; Reviewed
 16-191 5.96e-04

NADH:ubiquinone oxidoreductase subunit M; Reviewed


Pssm-ID: 235622 [Multi-domain]  Cd Length: 497  Bit Score: 41.34  E-value: 5.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  16 GTMIVMMSSHWLMIWIGFEMNLLAIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAII----INLMHSGQWTITKIFN 91
Cdd:PRK05846  123 GVIGVFAALDLLLFYVFFEAMLIPMYFLIGVWGGKNRIYAATKFFLYTLLGSLLMLVAIIylvvVYYNATGTFDIADLLN 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  92 PTASIIMTSAL--------AMKLGLTPFHFWVPEV-----TQGISLTSGLILltwqKLAP---MSILYQISPSINLN--- 152
Cdd:PRK05846  203 LPLPPGVQYWLflaffiafAVKMPMFPLHTWLPDAhvqapTAGSVLLAGILL----KMGAyglLRFSLPLFPDASHEfap 278

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1109490503 153 ILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMM 191
Cdd:PRK05846  279 IIITLGVIAIIYGALVALAQTDIKKLIAYSSISHMGFVT 317
PRK12650 PRK12650
DUF4040 family protein;
9-263 9.17e-04

DUF4040 family protein;


Pssm-ID: 237158 [Multi-domain]  Cd Length: 962  Bit Score: 41.18  E-value: 9.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   9 ILMTVFLGTMIVM-MSSHWLMIWIGFEMNLLAIIpILMKKYSPRAMEASTKYFLTQATASMLLMMAIII----------- 76
Cdd:PRK12650  114 LLMTAFMAAMLLLvLADDVVVLFVAWELVSLASF-FLIARSGSGGEAGSIRTLILTFFGGLTLLAAVAIaatqtgttsls 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  77 NLMHSGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLN---- 152
Cdd:PRK12650  193 GILHSDVWAEKPGLTTVVAVLIAVAAFTKSAQFPFHFWLPEAMAAITPVSAFLHAAAVVKAGIYLLLRFSPVFHDVavwn 272

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 153 -ILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYNPTLTM----LNMLIYIMMTLTMFMLFIHSSSTT- 226
Cdd:PRK12650  273 wLLIIVGMITALMGAVFAVQKTDLKKLTAYSTVSQLGWIVATIGVGTPFALtaavVHTLAHALFKSSLFMLIGVVDHQAg 352

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1109490503 227 ---TLSLSHTWNKTPLTTTLILITLLSMGGLPPLSGFMPK 263
Cdd:PRK12650  353 trdIRRLGSLWRRMPFTFVSVTIAALSMAAVPPLFGFVSK 392
ND4 MTH00014
NADH dehydrogenase subunit 4; Validated
 1-192 1.31e-03

NADH dehydrogenase subunit 4; Validated


Pssm-ID: 214399 [Multi-domain]  Cd Length: 452  Bit Score: 40.49  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503   1 MNPLILTIILMTVFLgtmivmmSSHWLMIWIGFEMNLL-AIIPILMKKYSPRAMEASTKYFLTQATASMLLMMAIII--- 76
Cdd:MTH00014   94 TNILILNLILLLTFS-------ASNLLMFYIFFEASLIpTLFLILGWGYQPERLQASFYLMIYTVTASLPLLMSILLify 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  77 -----NLMHSGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVPE------VTQGISLTSGLILLTWQKLAPMSILYQI 145
Cdd:MTH00014  167 tnnslSMLMSSMEPPSIYLMNLWWLITILAFMVKMPLYTVHLWLPKahveapVAGSMILAGILLKLGGYGLLRMSSLFMH 246

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1109490503 146 SPSINLNILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMA 192
Cdd:MTH00014  247 INKSLSAPFSSISLVGAVITSLICIRQPDLKSLIAYSSVGHMGLMTA 293
ND2 MTH00091
NADH dehydrogenase subunit 2; Provisional
 102-317 1.83e-03

NADH dehydrogenase subunit 2; Provisional


Pssm-ID: 177154  Cd Length: 273  Bit Score: 39.47  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 102 LAMKLGLTPFHFWVPEVTQGISLTSGLILLTWQKLAPMSILYQISPSINLNILLTMAVLSILVggwgGLNQTQLRKIMAY 181
Cdd:MTH00091   67 LMMKIGVAPFHFWIFSVTNGLFGWNLMWFLTFQKLPFLLVLLQFFSKNFFFLLLFGLLICFFQ----MFLLKSYKNLLIL 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 182 SSIAHMGWMMAVLAYNptltmLNMLIYIMMTLTMFMLFIhssstttlslSHTWNKTPLTTTLILITLLSMGGLPPLSGFM 261
Cdd:MTH00091  143 SSTESFNWLILSFFFS-----FFNVFFLFFYYFLLMLFL----------IPKFNNVNKLNFVSWETLLVFMNLPFSVTFF 207

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1109490503 262 PKWMIIQELTKNSSIILPTLMAIMALLNLYFYMRLTYSTSLTMFPSTNNMKMKWQF 317
Cdd:MTH00091  208 VKIFSLSEILKVLGFFLLFLLFLMFLSVLSLSFWLVNLSTKLFLMLFKYNKGFFFF 263
ND4 MTH00217
NADH dehydrogenase subunit 4; Provisional
 101-188 2.80e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214462 [Multi-domain]  Cd Length: 482  Bit Score: 39.26  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 101 ALAMKLGLTPFHFWVPE-----------VTQGISLT---SGLILLTWQKLAPMSILYqiSPSInlnilLTMAVLSILVGG 166
Cdd:MTH00217  215 SLAIKIPKIPFHIWLPQahveapvagsvILAGVLLKlggYGFIRFSWPLLPEASEYF--SPLI-----QTLSLLAIIYGS 287

                          90       100
                  ....*....|....*....|..
gi 1109490503 167 WGGLNQTQLRKIMAYSSIAHMG 188
Cdd:MTH00217  288 LTTCRQVDLKRIIAYSSVAHMG 309
PRK12561 PRK12561
NAD(P)H-quinone oxidoreductase subunit 4; Provisional
 55-218 3.73e-03

NAD(P)H-quinone oxidoreductase subunit 4; Provisional


Pssm-ID: 237137 [Multi-domain]  Cd Length: 504  Bit Score: 38.86  E-value: 3.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503  55 ASTKYFLTQATASMLLMMA----------IIINLMHSGQWTITKIFNPTASIIMTSALAMKLGLTPFHFWVP----EVTQ 120
Cdd:PRK12561  138 AATKFILYTALASIFILVAglalalsgdtFTFDLAELGAKSYPLALELLLYAGFLIAFGVKLPIFPLHTWLPdahgEASA 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 121 GISLTSGLILLTWQKLAPMSILYQISPSINLN---ILLTMAVLSILVGGWGGLNQTQLRKIMAYSSIAHMGWMMAVLAYN 197
Cdd:PRK12561  218 PVSMILAGVLLKMGGYALIRFNVQMLPDAHVYfapALAILGVVNIIYGALNAFAQDNVKRRLAYSSVSHMGFVLLGIAAF 297

                         170       180
                  ....*....|....*....|....*
gi 1109490503 198 PTL----TMLNMLIYIMMTLTMFML 218
Cdd:PRK12561  298 TDLgisgAMLQMISHGLIAAALFFL 322
ND4 MTH00226
NADH dehydrogenase subunit 4; Provisional
 101-188 6.00e-03

NADH dehydrogenase subunit 4; Provisional


Pssm-ID: 214466 [Multi-domain]  Cd Length: 505  Bit Score: 38.36  E-value: 6.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1109490503 101 ALAMKLGLTPFHFWVPEV-----TQGISLTSGlILLTWQKLAPMSILYQISPSINLNI---LLTMAVLSILVGGWGGLNQ 172
Cdd:MTH00226  239 AMAVKIPIFPFHIWLPKAhveapVAGSVLLAG-ILLKLGGYGLVRLSWPILPLGAQNLapaVIAMGIVGIVYGSFATCRQ 317

                          90
                  ....*....|....*.
gi 1109490503 173 TQLRKIMAYSSIAHMG 188
Cdd:MTH00226  318 IDVKRLVAYSSVAHMG 333
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH