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Conserved domains on  [gi|1108623777|gb|APF22132|]
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ROK family protein [Clostridium butyricum]

Protein Classification

ROK family transcriptional regulator( domain architecture ID 12122468)

NagC/ROK (Repressor, ORF, Kinase) family transcriptional regulator is involved in carbohydrate-dependent transcriptional control; contains an ArsR family winged helix-turn-helix domain

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0006355
SCOP:  4000330

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 79-389 3.13e-44

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


:

Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 155.44  E-value: 3.13e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  79 NPSFGFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHF-NVQHINQAIIELIN--IACETLDTSKIIGAGIAIPGHFDS 155
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGaGPEAVLEAIAELIEelLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 156 VNKSIISNNKM--WENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSN 232
Cdd:COG1940    81 ETGVVLNAPNLpgWRGVPLAElLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 233 FYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENstntilhslvetsDEINIKTIIDAYKLNDPYFKER 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGA-------------EKLTAEELFAAARAGDPLALEV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 313 IILGLKLLGTSIANTLIMQDAEKIYLNSELFTNDEfktFILEIIENQL---IFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:COG1940   228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGD---LLLEPIREALakyALPPAREDPRIVPASLGDDAGLLGAAALA 304
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 17-65 6.48e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


:

Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 6.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1108623777  17 VLEFIYRNPQTSRIEIAYSTGITPATITSIVGELLNKKLIIETGAEVQG 65
Cdd:pfam12802  10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 79-389 3.13e-44

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 155.44  E-value: 3.13e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  79 NPSFGFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHF-NVQHINQAIIELIN--IACETLDTSKIIGAGIAIPGHFDS 155
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGaGPEAVLEAIAELIEelLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 156 VNKSIISNNKM--WENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSN 232
Cdd:COG1940    81 ETGVVLNAPNLpgWRGVPLAElLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 233 FYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENstntilhslvetsDEINIKTIIDAYKLNDPYFKER 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGA-------------EKLTAEELFAAARAGDPLALEV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 313 IILGLKLLGTSIANTLIMQDAEKIYLNSELFTNDEfktFILEIIENQL---IFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:COG1940   228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGD---LLLEPIREALakyALPPAREDPRIVPASLGDDAGLLGAAALA 304
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 86-389 8.85e-32

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 122.31  E-value: 8.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDANHF-NVQHINQAIIELIN-IACETLDTSKIIGAGIAIPGHFDSVNKSII-- 161
Cdd:cd24059     4 IGVEIGRDLLSAVLCDLSGNILAREKYPLDEKeNPEEVLEKLYELIDrLLEKENIKSKILGIGIGAPGPLDVEKGIILnp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 162 SNNKMWENFSLLKINKN-FNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGH 240
Cdd:cd24059    84 PNFPGWENIPLVELLEEkFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIGH 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 241 TVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTILHslvetsdeiniktIIDAYKLNDPYFKERIILGLKLL 320
Cdd:cd24059   164 TSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRSFQLD-------------IVEALQKGDPIADEVIEEAAKYL 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 321 GTSIANTLIMQDAEKIYLNSEL-FTNDEFKTFILEIIENQLIFIPtKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24059   231 GIGLVNLINLLNPEAIIIGGELiYLGERYLEPIEKEVNSRLFGRN-AREVRILKSSLGEDAPLLGAAALV 299
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 119-389 1.83e-23

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 98.95  E-value: 1.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 119 VQHINQAIIELINIACETLDtsKIIGAGIAIPGHFDSVNKSIISN-NKMWENFSLL-KINKNFNFPIIAENNIECMALGE 196
Cdd:pfam00480  35 EETLVDAIAFFVDSAQRKFG--ELIAVGIGSPGLISPKYGYITNTpNIGWDNFDLVeKLEERFNVPVFFENDANAAALAE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 197 YLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKylfe 276
Cdd:pfam00480 113 AVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQ---- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 277 nstntilhslvETSDEINIKTIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAEKIYLNSELFTNDEFKTFILEII 356
Cdd:pfam00480 189 -----------QKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGGGVSNADGLLEAIRSLV 257

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1108623777 357 ENQLIFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:pfam00480 258 KKYLNGYLPVPPVIIVAASLGDNAGALGAAALA 290
PRK09698 PRK09698
D-allose kinase; Provisional
 85-316 1.26e-05

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 46.51  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  85 FLGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHINQAIIELIniaCETLD--TSKIIGAGIAIPGHFDSVNKSIIS 162
Cdd:PRK09698    6 VLGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMI---DEYLRrfNARCHGIVMGFPALVSKDRRTVIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 163 --NNKMWE-NFSLL--KINKNFNFPIIAENNIECMALGEYLFNPLnTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGE 237
Cdd:PRK09698   83 tpNLPLTAlDLYDLadKLENTLNCPVFFSRDVNLQLLWDVKENNL-TQQLVLGAYLGTGMGFAVWMNGAPWTGAHGVAGE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 238 IGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENStnTILHSLVETSDEINIKTIID------AYKLN--DPyf 309
Cdd:PRK09698  162 LGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDY--PLSDLFVHAGDHPFIQSLLEnlaraiATSINlfDP-- 237


                  ....*..
gi 1108623777 310 kERIILG 316
Cdd:PRK09698  238 -DAIILG 243
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 17-65 6.48e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 6.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1108623777  17 VLEFIYRNPQTSRIEIAYSTGITPATITSIVGELLNKKLIIETGAEVQG 65
Cdd:pfam12802  10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-56 3.31e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.80  E-value: 3.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1108623777    8 DAFNINMS--TVLEFIYRNPQTSRIEIAYSTGITPATITSIVGELLNKKLI 56
Cdd:smart00347   4 KPLGLTPTqfLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
 
Name Accession Description Interval E-value
NagC COG1940
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ...
 79-389 3.13e-44

Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];


Pssm-ID: 441543 [Multi-domain]  Cd Length: 306  Bit Score: 155.44  E-value: 3.13e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  79 NPSFGFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHF-NVQHINQAIIELIN--IACETLDTSKIIGAGIAIPGHFDS 155
Cdd:COG1940     1 NPDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGaGPEAVLEAIAELIEelLAEAGISRGRILGIGIGVPGPVDP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 156 VNKSIISNNKM--WENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSN 232
Cdd:COG1940    81 ETGVVLNAPNLpgWRGVPLAElLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGAN 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 233 FYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENstntilhslvetsDEINIKTIIDAYKLNDPYFKER 312
Cdd:COG1940   161 GNAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGGA-------------EKLTAEELFAAARAGDPLALEV 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 313 IILGLKLLGTSIANTLIMQDAEKIYLNSELFTNDEfktFILEIIENQL---IFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:COG1940   228 LDEAARYLGIGLANLINLLDPEVIVLGGGVSAAGD---LLLEPIREALakyALPPAREDPRIVPASLGDDAGLLGAAALA 304
ASKHA_NBD_ROK_TM1224-like cd24059
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ...
 86-389 8.85e-32

nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466909 [Multi-domain]  Cd Length: 305  Bit Score: 122.31  E-value: 8.85e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDANHF-NVQHINQAIIELIN-IACETLDTSKIIGAGIAIPGHFDSVNKSII-- 161
Cdd:cd24059     4 IGVEIGRDLLSAVLCDLSGNILAREKYPLDEKeNPEEVLEKLYELIDrLLEKENIKSKILGIGIGAPGPLDVEKGIILnp 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 162 SNNKMWENFSLLKINKN-FNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGH 240
Cdd:cd24059    84 PNFPGWENIPLVELLEEkFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGEIGH 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 241 TVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTILHslvetsdeiniktIIDAYKLNDPYFKERIILGLKLL 320
Cdd:cd24059   164 TSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRSFQLD-------------IVEALQKGDPIADEVIEEAAKYL 230

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 321 GTSIANTLIMQDAEKIYLNSEL-FTNDEFKTFILEIIENQLIFIPtKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24059   231 GIGLVNLINLLNPEAIIIGGELiYLGERYLEPIEKEVNSRLFGRN-AREVRILKSSLGEDAPLLGAAALV 299
ASKHA_ATPase_ROK_Lmo0178-like cd24071
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ...
 83-389 2.46e-30

ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466921 [Multi-domain]  Cd Length: 312  Bit Score: 118.54  E-value: 2.46e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  83 GFFLGIEFNMKGLFLSITDACGNIVSNFKKDANH-FNVQHINQAIIELINIAC-ETLDTSKIIGAGIAIPGHFDS----V 156
Cdd:cd24071     1 GYIIGVKIEEGYLVLALTDLKGKILEKTRIPFDHeTDPEKVIELIAENIKKLIkNKHVEKKLLGIGIAVSGLVDSkkgiV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 157 NKSIISNnkmWENFSLLKI-NKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIgFKSNF-Y 234
Cdd:cd24071    81 IRSTILG---WENVELKKIlKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKL-YTGNFgG 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 235 LGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKylfENSTNTILHSLVETSDeINIKTIIDAYKLNDPYFKERII 314
Cdd:cd24071   157 AGEIGHMTIQPDGRKCYCGQKGCLEAYASFEALVNEIK---ELTESYPLSLLKELED-FEIEKVREAAEEGDSVATELFK 232

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1108623777 315 LGLKLLGTSIANTLIMQDAEKIYLNSELFtndEFKTFILEIIENQL---IFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24071   233 KAGEYLGIGIKNLINIFNPEAIIIGGEGL---EFKDYFLPKIIEIAkenFFGKAGRNVIILVDSLGEDAWVLGAALLV 307
ASKHA_ATPase_ROK_CYANR cd24073
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ...
 83-389 2.88e-28

ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466923 [Multi-domain]  Cd Length: 304  Bit Score: 112.65  E-value: 2.88e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  83 GFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHINQAIIELIN--IACETLDTSKIIGAGIAIPGHFDSVNKSI 160
Cdd:cd24073     1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAelLAQAGLSPDRLLGIGVGLPGLVDAETGIC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 161 I-SNNKMWENFSL--LkINKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGE 237
Cdd:cd24073    81 RwSPLLGWRDVPLaeL-LEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGAGE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 238 IGHTVVDINGPKCECGKNGCLQTYISESWLIKSAkylfenstntilHSLVETSDEINIKTIIDAYKLNDPyfKERIILGL 317
Cdd:cd24073   160 IGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQA------------REAGLRGEPLTIEDLLAAARAGDP--AARAILRR 225

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1108623777 318 --KLLGTSIANTLIMQDAEKIYLNSE-LFTNDEFKTFILEIIEnQLIFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24073   226 agRALGLALANLVNLLDPELIIISGEgVRAGDLLFEPMREALR-AHVFPGLASDLELVIHPWGDEAWARGAAALA 299
ASKHA_ATPase_ROK_BsXylR-like cd24076
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ...
 83-389 1.98e-27

ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.


Pssm-ID: 466926 [Multi-domain]  Cd Length: 303  Bit Score: 110.35  E-value: 1.98e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  83 GFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHIN-QAIIELINIACETLDTSK--IIGAGIAIPGHFDSVN-K 158
Cdd:cd24076     1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDPDEVlAQLAALIREALAAAPDSPlgILGIGVGVPGLVDSEDgV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 159 SIISNNKMWENFSLLKI-NKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGE 237
Cdd:cd24076    81 VLLAPNLGWRDVPLRDLlEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYRGASGFAGE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 238 IGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKylfenstntilhSLVETSDEINIKTIIDAYKLNDPyfkeRIILGL 317
Cdd:cd24076   161 IGHMTVDPDGPPCSCGNRGCWETYASERALLRAAG------------RLGAGGEPLSLAELVEAARAGDP----AALAAL 224

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1108623777 318 ----KLLGTSIANTLIMQDAEKIYLNSELftnDEFKTFILEIIE---NQLIFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24076   225 eevgEYLGIGLANLVNTFNPELVVLGGAL---APLGPWLLPPLRaevARRALPAPARDVRIVVSRLGEDAAALGAAALA 300
ASKHA_ATPase_ROK_YphH-like cd24072
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ...
 86-361 6.93e-26

ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466922 [Multi-domain]  Cd Length: 308  Bit Score: 106.35  E-value: 6.93e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDA-NHFNVQHINQAIIELINIACEtLDTSKIIGAGIAIPGHFDSVNKSII-SN 163
Cdd:cd24072     4 LGIVVSPNSLRAQVGNACGELLGEFEYRViTLETPEALIDEIIDCIDRLLK-LWKDRVKGIALAIQGLVDSHKGVSLwSP 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 164 NKMWENFSLLKI-NKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTV 242
Cdd:cd24072    83 GAPWRNIEIKYLlEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSGEIGHTK 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 243 VDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTILHSlvetsdEINIKTIIDAYKLNDPYFKERIILGLKLLGT 322
Cdd:cd24072   163 VNPDGARCDCGRRGCLETVASNSALKRNARVTLKLGPVSADPE------KLTMEQLIEALEEGEPIATQIFDRAANAIGR 236

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 1108623777 323 SIANTLIMQDAEKIYLNSELFT-NDEFKTFILEIIENQLI 361
Cdd:cd24072   237 SLANILNLLNPEQVLLYGRGCRaGDLLLPAIRRAIAENPF 276
ASKHA_ATPase_ROK_SaXylR-like cd24077
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ...
 83-389 7.87e-25

ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.


Pssm-ID: 466927 [Multi-domain]  Cd Length: 295  Bit Score: 103.00  E-value: 7.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  83 GFFLGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHINQAIIELINIACETLDTSK--IIGAGIAIPGhfdsvnksI 160
Cdd:cd24077     1 GYSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPygLVGIGIGIHG--------I 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 161 ISNNKM-------WENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSn 232
Cdd:cd24077    73 VDENEIiftpyydLEDIDLKEkLEEKFNVPVYLENEANLSALAERTFSEDYDNLISISIHSGIGAGIIINNQLYRGYNG- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 233 fYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENstntilhslvetsDEINIKTIIDAYKLNDPYFKER 312
Cdd:cd24077   152 -FAGEIGHMIIVPNGKPCPCGNKGCLEQYASEKALLKELSEKKGL-------------ETLTFDDLIQLYNEGDPEALEL 217

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1108623777 313 IILGLKLLGTSIANTLIMQDAEKIYLNSELFTndEFKTfILEIIENQLiFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:cd24077   218 IDQFIKYLAIGINNIINTFNPEIIIINSSLIN--EIPE-LLEKIKEQL-SSSFNKYVEILISTLGKNATLLGGAAVA 290
ROK pfam00480
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ...
 119-389 1.83e-23

ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.


Pssm-ID: 395384 [Multi-domain]  Cd Length: 292  Bit Score: 98.95  E-value: 1.83e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 119 VQHINQAIIELINIACETLDtsKIIGAGIAIPGHFDSVNKSIISN-NKMWENFSLL-KINKNFNFPIIAENNIECMALGE 196
Cdd:pfam00480  35 EETLVDAIAFFVDSAQRKFG--ELIAVGIGSPGLISPKYGYITNTpNIGWDNFDLVeKLEERFNVPVFFENDANAAALAE 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 197 YLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKylfe 276
Cdd:pfam00480 113 AVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGHIQLDPNGPKCGCGNHGCLETIASGRALEKRYQ---- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 277 nstntilhslvETSDEINIKTIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAEKIYLNSELFTNDEFKTFILEII 356
Cdd:pfam00480 189 -----------QKGEDLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIANLINLFDPQAIVLGGGVSNADGLLEAIRSLV 257

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1108623777 357 ENQLIFIPTKRNVDIEIENFNYNRASTGACALA 389
Cdd:pfam00480 258 KKYLNGYLPVPPVIIVAASLGDNAGALGAAALA 290
ASKHA_ATPase_ROK_NagC cd24075
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ...
 86-388 8.46e-22

ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466925 [Multi-domain]  Cd Length: 315  Bit Score: 94.74  E-value: 8.46e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHINQAIIELIN--IACETLDTSKIIGAGIAIPGHFDSvNKSIISN 163
Cdd:cd24075     4 LAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAqfLKSHRRKTQRLIAISITLPGLINP-KTGVVHY 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 164 NKMW--ENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGH 240
Cdd:cd24075    83 MPHIqvKSWPIVEeLEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEIGH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 241 TVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTILhslveTSDEINIKTIIDAYKLNDPYFKERIILGLKLL 320
Cdd:cd24075   163 IQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQL-----TLQDCTIKDICQAALNGDQLAQDVIKRAGRYL 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1108623777 321 GTSIANTLIMQDAEKIYLNSELFTNDEfktFILEIIENQL------IFiptKRNVDIEIENFNYNRAsTGACAL 388
Cdd:cd24075   238 GKVIAILINLLNPQKIIIAGEITQADK---VLLPVIKKCIqsqalpDF---RQELKIVASQLDHNSA-IGAFAL 304
ASKHA_NBD_ROK_TmGLK-like cd24064
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ...
 86-336 1.69e-20

nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466914 [Multi-domain]  Cd Length: 301  Bit Score: 91.02  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDANHFN-----VQHINQAIIELIniacetlDTSKIIGAGIAIPGHFDSVNKSI 160
Cdd:cd24064     2 IGIDLGGTDTKIGIVDENGDILKKKTIDTKVENgkedvINRIAETVNELI-------EEMELLGIGIGSPGSIDRENGIV 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 161 I--SNNKMWENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGE 237
Cdd:cd24064    75 RfsPNFPDWRNFPLVPlIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTGVGSGVICHGQLLTGYDGIAAE 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 238 IGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNtilhSLVETSDEINIKTIIDAYKLNDPY---FKERII 314
Cdd:cd24064   155 LGHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPD----SLAGESEKINAKHVFDAARKNDPLatmVFRRVV 230

                         250       260
                  ....*....|....*....|..
gi 1108623777 315 lglKLLGTSIANTLIMQDAEKI 336
Cdd:cd24064   231 ---DALAIAIGGFVHIFNPEII 249
ASKHA_NBD_ROK_GNE cd24060
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ...
 141-375 3.16e-19

nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.


Pssm-ID: 466910 [Multi-domain]  Cd Length: 305  Bit Score: 87.47  E-value: 3.16e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 141 KIIGAGIAIPGHFDSVNKSIISNNKMWENFSLLK----INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHG 216
Cdd:cd24060    59 RILGVGISTGGRVNPREGIVLHSTKLIQEWSSVDlrtpISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 217 LFCSFFNSNHIGFKSNFYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTILHSLVETSDEINIK 296
Cdd:cd24060   139 IGGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYASGMALQREAKKLHDEDLLLVEGMSVTNDEEVTAK 218

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1108623777 297 TIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAEKIYLNSELftNDEFKTFILEIIENQLifIPTKRNVDIEIEN 375
Cdd:cd24060   219 HLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVL--ASHYENIVKDVIAQRA--LPSVQNVDVVVSD 293
ASKHA_ATPase_ROK cd23763
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ...
 86-243 1.85e-17

ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.


Pssm-ID: 466849 [Multi-domain]  Cd Length: 239  Bit Score: 80.97  E-value: 1.85e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  86 LGIEFNMKGLFLSITDACGNIVSNFKKDAN-HFNVQHINQAIIELINIACETLDT-SKIIGAGIAIPGHFDSVNKSIIS- 162
Cdd:cd23763     1 IGIDIGGTKIRAALVDLDGEILARERVPTPaEEGPEAVLDRIAELIEELLAEAGVrERILGIGIGVPGPVDPETGIVLFa 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 163 -NNKMWENFSLLKI-NKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHI--GfkSNFYLGEI 238
Cdd:cd23763    81 pNLPWWKNVPLRELlEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLyrG--ANGAAGEI 158


                  ....*
gi 1108623777 239 GHTVV 243
Cdd:cd23763   159 GHITV 163
ASKHA_NBD_ROK_ApGLK-like cd24063
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ...
 122-369 6.54e-17

nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466913 [Multi-domain]  Cd Length: 308  Bit Score: 80.85  E-value: 6.54e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 122 INQAIIELINIACETLDTSKIIGAGIAIPGHFDSVNKSII-SNNKMWENFSLLK-INKNFNFPIIAENNIECMALGEYLF 199
Cdd:cd24063    40 VSEQVLGLIETLLSKAGKDSIEGIGVSSAGPLDLRKGTIVnSPNIKGKEIPLVEpLKEEFNIPVALLNDAVAAALGEHLF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 200 NPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTVVDIN-GPKCECGKNGCLQTYISESWLIKSAKYLFENS 278
Cdd:cd24063   120 GAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEVGHLVVDTEsGLKCGCGGYGHWEAFASGRGIPRFAREWAEGF 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 279 TNTILHSLVETSDE-INIKTIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAEKIYLNSELFTNdefktfileiie 357
Cdd:cd24063   200 SSRTSLKLRNPGGEgITAKEVFSAARKGDPLALKIIEKLARYNGRGIANVINAYDPELIVIGGSVFNN------------ 267

                         250
                  ....*....|..
gi 1108623777 358 NQLIFIPTKRNV 369
Cdd:cd24063   268 NKDILDPLIEYL 279
ASKHA_NBD_ROK_FnNanK-like cd24068
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ...
 101-388 2.48e-16

nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466918 [Multi-domain]  Cd Length: 294  Bit Score: 78.75  E-value: 2.48e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 101 DACGNIVSNFKKDANHFNVQH-INQAIIELINiacETLDTSKIIGAGIAIPGHFDSVNKSIIS---NNKMWENFSLLK-I 175
Cdd:cd24068    18 DADGEILEKDSVPTPASKGGDaILERLLEIIA---ELKEKYDIEGIGISSAGQVDPKTGEVIYatdNLPGWTGTNLKEeL 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 176 NKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHG----------LFCSFfnsnhigfksNFYLGEIGHTVVDI 245
Cdd:cd24068    95 EERFGLPVAVENDVNCAALAEKWLGAAKGLDDFLCLTLGTGiggaiildgrLYRGA----------NGSAGELGHMVVDP 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 246 NGPKCECGKNGCLQTYISESWLIKSAKYLFEnstntilhslvetSDEINIKTIIDAYKLNDPYFKERIILGLKLLGTSIA 325
Cdd:cd24068   165 GGRPCCCGGKGCLEQYASGTALVRRVAEALG-------------EPGIDGREIFDLADAGDPLAKEVVEEFAEDLATGLA 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1108623777 326 NTLIMQDAEKIYL------NSELFTNDefktfILEIIENQLIFiPTKRNVDIEIENFNYNRASTGACAL 388
Cdd:cd24068   232 NLVHIFDPEVIVIgggisaQGELFLEE-----LREELRKLLMP-PLLDATKIEPAKLGNDAGLLGAAYL 294
ASKHA_NBD_ROK_BsGLK-like cd24062
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ...
 121-336 3.34e-16

nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466912 [Multi-domain]  Cd Length: 311  Bit Score: 78.49  E-value: 3.34e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 121 HINQAIIELINIACETLDTSK--IIGAGIAIPGHFDSVNKSII-SNNKMWENFSLL-KINKNFNFPIIAENNIECMALGE 196
Cdd:cd24062    39 NIITDIAESIQQLLEELGYSKedLIGIGVGVPGPVDVETGTVEvAVNLGWKNFPLKdKLEALTGIPVVIDNDANAAALGE 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 197 YLFNPLNTPEKFLFLH----VGHGLFCsffNSNHI-GFksNFYLGEIGH-TVVDINGPKCECGKNGCLQTYISESWLIKS 270
Cdd:cd24062   119 MWKGAGQGAKDLVFITlgtgVGGGVIA---NGKIVhGA--NGAAGEIGHiTVNPEGGAPCNCGKTGCLETVASATGIVRI 193

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1108623777 271 AKYLFENSTNTILHSLVETSDEINIKTIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAEKI 336
Cdd:cd24062   194 AREELEEGKGSSALRILALGGELTAKDVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKI 259
ASKHA_NBD_ROK_SgGLK-like cd24061
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ...
 101-272 7.44e-14

nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466911 [Multi-domain]  Cd Length: 306  Bit Score: 71.62  E-value: 7.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 101 DACGNIVSNFKKDANHfNVQHINQAIIELINiacETLDTSKIIGAGIAIPGHFDSVNKSII-SNNKMWENFSLL-KINKN 178
Cdd:cd24061    17 DEEGEILATERVPTPP-TADGIVDAIVEAVE---ELREGHDVSAVGVAAAGFVDADRATVLfAPNIAWRNEPLKdLLEAR 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 179 FNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIgFKSNFYL-GEIGHTVVDINGPKCECGKNGC 257
Cdd:cd24061    93 IGLPVVIENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKL-LRGAFGIaGEFGHIRVVPDGLLCGCGSRGC 171

                         170
                  ....*....|....*
gi 1108623777 258 LQTYISESWLIKSAK 272
Cdd:cd24061   172 WEQYASGRALVRYAK 186
ASKHA_ATPase_ROK_Mlc cd24074
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ...
 175-383 1.15e-13

ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466924 [Multi-domain]  Cd Length: 322  Bit Score: 71.19  E-value: 1.15e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 175 INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTVVDINGPKCECGK 254
Cdd:cd24074    98 LEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLGELGHTQIDPYGKRCYCGN 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 255 NGCLQTYISESWLIKSAKYLFENSTNTILHslvetSDEINIKTIIDAYKLNDPYFKERIILGLKLLGTSIANTLIMQDAE 334
Cdd:cd24074   178 HGCLETVASIPAILEQANQLLEQSPDSMLH-----GQPISIESLCQAALAGDPLAQDIIIQVGRHLGRILAILVNLFNPE 252

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1108623777 335 KIYLNSELFTNDE-FKTFILEIIENQLifiPTKRNVDIEIENFNYNRAST 383
Cdd:cd24074   253 KILIGSPLNNAAEiLFPALSQSIRQQS---LPAYSQHLQIESTKFYNDGT 299
ASKHA_NBD_ROK_AlsK cd24070
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ...
 124-272 1.47e-09

nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466920 [Multi-domain]  Cd Length: 293  Bit Score: 58.71  E-value: 1.47e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 124 QAIIELINIACETLDtSKIIGAGIAIPGHFDSVNKSIIS--NNKMWENFSLL-KINKNFNFPIIAENNIECMALGEYLFN 200
Cdd:cd24070    43 EVLADLIREYIEEAG-LKPAAIVIGVPGTVDKDRRTVIStpNIPGLDGVNLAdILENKLGIPVILERDVNLLLLYDMRAG 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1108623777 201 PLNTPEKFLFLHVGHGLFCSFFnsnhigFKSNFYLG------EIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAK 272
Cdd:cd24070   122 NLDDEGVVLGFYIGTGIGNAIL------INGKPLRGkngvagELGHIPVYGNGKPCGCGNTGCLETYASGRALEEIAE 193
ASKHA_NBD_ROK_TtHK-like cd24065
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ...
 146-301 1.92e-08

nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466915 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 146 GIAIPGHFDSVNKSII--SNNKMWENFSLL-KINKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFF 222
Cdd:cd24065    60 GLGVPGPLDFRRGRVRfaPNIPGLTDFPIRrGLAERLGLPVVLENDANAAALAEHHYGAARGTESSVYVTISTGIGGGLV 139

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 223 NSNHIGFKSNFYLGEIGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENSTNTI-LHSLVETSDEINIKTIIDA 301
Cdd:cd24065   140 LGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRALARDASFAYGRPMSTAeLFELAQQGEPKALRIVEQA 219
ASKHA_NBD_ROK_EcNanK-like cd24069
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ...
 163-263 6.53e-08

nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466919 [Multi-domain]  Cd Length: 283  Bit Score: 53.44  E-value: 6.53e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 163 NNKM---WENFSLLK-INKNFNFPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEI 238
Cdd:cd24069    72 NPKNlggLSGFPLADaLQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHI 151

                          90       100
                  ....*....|....*....|....*
gi 1108623777 239 GHTVVDINGPKCECGKNGCLQTYIS 263
Cdd:cd24069   152 GHTLADPPGPVCGCGRRGCVEAIAS 176
PRK09698 PRK09698
D-allose kinase; Provisional
 85-316 1.26e-05

D-allose kinase; Provisional


Pssm-ID: 182034 [Multi-domain]  Cd Length: 302  Bit Score: 46.51  E-value: 1.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777  85 FLGIEFNMKGLFLSITDACGNIVSNFKKDANHFNVQHINQAIIELIniaCETLD--TSKIIGAGIAIPGHFDSVNKSIIS 162
Cdd:PRK09698    6 VLGIDMGGTHIRFCLVDAEGEILHCEKKRTAEVIAPDLVSGLGEMI---DEYLRrfNARCHGIVMGFPALVSKDRRTVIS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 163 --NNKMWE-NFSLL--KINKNFNFPIIAENNIECMALGEYLFNPLnTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGE 237
Cdd:PRK09698   83 tpNLPLTAlDLYDLadKLENTLNCPVFFSRDVNLQLLWDVKENNL-TQQLVLGAYLGTGMGFAVWMNGAPWTGAHGVAGE 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 238 IGHTVVDINGPKCECGKNGCLQTYISESWLIKSAKYLFENStnTILHSLVETSDEINIKTIID------AYKLN--DPyf 309
Cdd:PRK09698  162 LGHIPLGDMTQHCGCGNPGCLETNCSGMALRRWYEQQPRDY--PLSDLFVHAGDHPFIQSLLEnlaraiATSINlfDP-- 237


                  ....*..
gi 1108623777 310 kERIILG 316
Cdd:PRK09698  238 -DAIILG 243
ASKHA_NBD_ROK-like cd24152
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ...
 104-249 2.75e-05

nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.


Pssm-ID: 466988 [Multi-domain]  Cd Length: 286  Bit Score: 45.64  E-value: 2.75e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1108623777 104 GNIVSNFKKDANHFNVQHINQAIIELINIACETLDtskiiGAGIAIPGHFDSVNKSII--SNNKMWENFSLLK-INKNFN 180
Cdd:cd24152    21 GNIIKKGKIPTPKDSLEEFLDYIKKIIKRYDEEID-----GIAISAPGVIDPETGIIYggGALPYLKGFNLKEeLEERCN 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1108623777 181 FPIIAENNIECMALGEYLFNPLNTPEKFLFLHVGHGLFCSFFNSNHIGFKSNFYLGEIGHTVVDINGPK 249
Cdd:cd24152    96 LPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAIIIDGKLYRGSHFFAGEFSYLLTDDDDKD 164
PRK05082 PRK05082
N-acetylmannosamine kinase; Provisional
 236-257 9.70e-05

N-acetylmannosamine kinase; Provisional


Pssm-ID: 235338 [Multi-domain]  Cd Length: 291  Bit Score: 43.75  E-value: 9.70e-05
                          10        20
                  ....*....|....*....|..
gi 1108623777 236 GEIGHTVVDINGPKCECGKNGC 257
Cdd:PRK05082  152 GHIGHTLADPHGPVCGCGRRGC 173
ASKHA_NBD_ROK_EcFRK-like cd24066
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ...
 224-263 5.62e-04

nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.


Pssm-ID: 466916 [Multi-domain]  Cd Length: 294  Bit Score: 41.42  E-value: 5.62e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1108623777 224 SNHIGfksnfylGEIGHTVVD------INGPKCECGKNGCLQTYIS 263
Cdd:cd24066   147 ANGIA-------GEWGHNPLPwpdedeLPGPPCYCGKRGCVETFLS 185
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 17-65 6.48e-04

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 37.57  E-value: 6.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1108623777  17 VLEFIYRNPQTSRIEIAYSTGITPATITSIVGELLNKKLIIETGAEVQG 65
Cdd:pfam12802  10 VLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADR 58
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
8-56 3.31e-03

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 36.80  E-value: 3.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1108623777    8 DAFNINMS--TVLEFIYRNPQTSRIEIAYSTGITPATITSIVGELLNKKLI 56
Cdd:smart00347   4 KPLGLTPTqfLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLV 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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