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Conserved domains on  [gi|110735437|ref|NP_003384|]
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protein Wnt-8b precursor [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 14443640)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
30-334 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381726  Cd Length: 305  Bit Score: 573.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  30 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 109
Cdd:cd19352    1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 110 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 189
Cdd:cd19352   81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 190 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 269
Cdd:cd19352  161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 270 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 334
Cdd:cd19352  241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
 
Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
30-334 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 573.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  30 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 109
Cdd:cd19352    1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 110 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 189
Cdd:cd19352   81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 190 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 269
Cdd:cd19352  161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 270 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 334
Cdd:cd19352  241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
WNT1 smart00097
found in Wnt-1;
23-333 5.35e-144

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 409.40  E-value: 5.35e-144
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437    23 WSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTR 102
Cdd:smart00097   3 PGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAVTR 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   103 NCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKC 182
Cdd:smart00097  83 ACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKC 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   183 HGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRgaIADTFRSISTRELVHLEDSPDYCLENKTL 262
Cdd:smart00097 163 HGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP--KNSTFKPPTETDLVYLESSPDFCEKNPKT 240
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110735437   263 GLLGTEGRECLRRGRALGrwerrSCRRLCGDCGLAVeeRRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:smart00097 241 GSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
42-333 4.85e-116

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 338.37  E-value: 4.85e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 120
Cdd:pfam00110  22 SVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRG 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  121 QLGGQGWLW-GGCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 198
Cdd:pfam00110 102 KSSGEGGWEwGGCSDNIDYGYKFSRKFVDAREkKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKAL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  199 PEFREVGAHLKEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 278
Cdd:pfam00110 182 PPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110735437  279 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:pfam00110 259 PD-----GCDLLC--CGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTC 306
 
Name Accession Description Interval E-value
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
30-334 0e+00

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 573.89  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  30 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 109
Cdd:cd19352    1 MTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 110 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 189
Cdd:cd19352   81 DNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSC 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 190 TTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEG 269
Cdd:cd19352  161 TTQTCWLQLPEFREVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAETFRSISKKELVHLEDSPDYCLENKTLGLLGTEG 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 270 RECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 334
Cdd:cd19352  241 RECLKRGKALSKWEKRSCRRLCGDCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFCV 305
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
31-334 1.94e-174

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 486.72  E-value: 1.94e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  31 TGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFD 110
Cdd:cd19351    1 TGPKAYLTYSSSVAAGAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFE 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 111 NCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCT 190
Cdd:cd19351   81 NCGCDDSRNGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCS 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 191 TQTCWLQLPEFREVGAHLKEKYHAALKVDLLQ---GAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGT 267
Cdd:cd19351  161 IQTCWLQLADFREIGNYLKVKHDQALKLEMDKrrmRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGT 240
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110735437 268 EGRECLRRGRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 334
Cdd:cd19351  241 EGRECLQSGKNLSQWERRSCRRLCTECGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYCA 307
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
31-334 6.52e-162

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 454.44  E-value: 6.52e-162
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  31 TGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALqlSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFD 110
Cdd:cd19340    1 SGPKAYLSLSDSVAAGAQLAMEECQYQFKWDRWNCPESAF--FSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFE 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 111 NCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCT 190
Cdd:cd19340   79 GCGCDDSKKGSKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCS 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 191 TQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIadTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGR 270
Cdd:cd19340  159 TQTCWMQLAPFREIGTDLKRKYDRAVRVDYENGGLRETNGSRAI--KLLNIKKNDLVYLEKSPNYCRANVTLGWPGTLGR 236
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 271 ECLRR-GRALGRWERRSCRRLCGDCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFCS 334
Cdd:cd19340  237 QCSRDkKESVSRWERKSCRRLCRACGLKVRKKVVEVTSSCNCKFHWCCEVKCETCVELVIEYTCV 301
WNT1 smart00097
found in Wnt-1;
23-333 5.35e-144

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 409.40  E-value: 5.35e-144
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437    23 WSVNNFLMTGPKAYLIYSSSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTR 102
Cdd:smart00097   3 PGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAVTR 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   103 NCSLGDFDNCGCDDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKC 182
Cdd:smart00097  83 ACSEGELDSCGCDYRKRGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECKC 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   183 HGVSGSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRgaIADTFRSISTRELVHLEDSPDYCLENKTL 262
Cdd:smart00097 163 HGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP--KNSTFKPPTETDLVYLESSPDFCEKNPKT 240
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110735437   263 GLLGTEGRECLRRGRALGrwerrSCRRLCGDCGLAVeeRRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:smart00097 241 GSLGTQGRQCNKTSKGLD-----GCDLLCCGRGYNT--RTVEVVERCNCKFHWCCYVKCKQCRETVEKHTC 304
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
41-333 1.49e-124

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 359.30  E-value: 1.49e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  41 SSVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 120
Cdd:cd13113    3 ESIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTRQG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 121 QLGGQGWLWGGCSDNVGFGEAISKQFVDALET--GQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 198
Cdd:cd13113   83 PEGQGDWTWGGCSDNIKFGIKFSRKFLDAREKkkGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWRQL 162
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 199 PEFREVGAHLKEKYHAALKVDLlqGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 278
Cdd:cd13113  163 PSFREIGDYLKEKYDNAVKVKL--NNNGSGLRLVPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNPTSPG 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 279 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd13113  241 PD-----SCELLC--CGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
42-333 4.85e-116

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 338.37  E-value: 4.85e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437   42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 120
Cdd:pfam00110  22 SVAEGAQLAIEECQHQFRNRRWNCSTLENKRPVFGKvLKRGTRETAFVYAISSAGVTHAVTRACSSGELTSCGCDRKKRG 101
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  121 QLGGQGWLW-GGCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQL 198
Cdd:pfam00110 102 KSSGEGGWEwGGCSDNIDYGYKFSRKFVDAREkKRRDARALMNLHNNEAGRKAVKSNMRTECKCHGVSGSCSVKTCWKAL 181
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  199 PEFREVGAHLKEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 278
Cdd:pfam00110 182 PPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNSRFKPPTKNDLVYLEKSPDYCERNPKTGSLGTRGRECNKTSSG 258
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 110735437  279 LGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:pfam00110 259 PD-----GCDLLC--CGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTC 306
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
42-333 3.98e-108

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 318.40  E-value: 3.98e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCPeraLQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNG 120
Cdd:cd19338   30 EVAKGAKLGIRECQYQFRNRRWNCS---TSRKSFGKiLKRDTRETAFVYAITSAGVTYSVTRACSMGELLQCGCDKSKRG 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 121 QLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQ-DARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLP 199
Cdd:cd19338  107 KSTEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRsDIRTLMNLHNNEAGRLAVKNNMRKECKCHGLSGSCTLKTCWRKMP 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 200 EFREVGAHLKEKYHAALKVDllqgAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRAL 279
Cdd:cd19338  187 PFREVGDRLKERFDGAIKVK----GSNDGKSLIPEGKTIKPPTKEDLVYLEESPDFCEPNKKTGSLGTRGRECNRTSMGV 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110735437 280 GrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19338  263 D-----GCDLLC--CGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTC 309
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
42-333 2.54e-100

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 298.87  E-value: 2.54e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCPERAlQLSSHGG--LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 119
Cdd:cd19334   29 SIGEGAKLGVKECQYQFRNQRWNCSTVD-RDATVFGkvLLKGSREAAFVYAISSAGVVHAITRACSKGELLNCACDPTKR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 120 GQLGGQGWLWG--GCSDNVGFGEAISKQFVDALETGQ-DARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19334  108 GKGRDSKGEFDwgGCSDNVKYGINFARKFVDARERRVrDARALMNLHNNRAGRKAVKKNLKLQCKCHGVSGSCTIRTCWR 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRgaiaDTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRG 276
Cdd:cd19334  188 ALAEFREVGDYLREKYDGAVQVTMNQSGTNLLAAN----KGHKKPTRSDLVYFESSPDYCVPNPETGSLGTAGRVCNKTS 263
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110735437 277 RALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19334  264 TGTD-----GCDIMC--CGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTC 313
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
42-333 4.43e-93

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 279.97  E-value: 4.43e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCpeRALQLSSHGG--LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 119
Cdd:cd19336   24 SVRRGAQLAIEECQFQFRNRRWNC--STLDKEPVFGkvLNQGTREAAFVHAISSAGVAHAVTRACSSGELEKCGCDRSVR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 120 GQLGGQGWLWGgCSDNVGFGEAISKQFVDALETG----QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCW 195
Cdd:cd19336  102 GRSPEGFQWSG-CSDNVAYGVAFSKSFVDARERRkgraSSSRALMNLHNNEAGRKAIEKNMRVECKCHGVSGSCELKTCW 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 196 LQLPEFREVGAHLKEKYHAALKVDLLQgagnsAAGRGAIA---DTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGREC 272
Cdd:cd19336  181 RAMPTFREVGNILKEKFDGATEVQQKR-----IGSRPVLVpknPQFKPHTDADLVYLDSSPDFCEPDPKTGSLGTHGRVC 255
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 110735437 273 LRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19336  256 NKTSKAID-----GCDLLC--CGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTC 309
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
42-333 9.64e-92

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 276.86  E-value: 9.64e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCperalqlSSHGG-------LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 114
Cdd:cd19339   25 AIGEGAQLGIEECQFQFRNHRWNC-------TLLGErtvfgqeLPVGSREAAFTYAITSAGVAYAITQACSQGNLSDCGC 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 115 DDSRNGQLGGQGWLW-GGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQT 193
Cdd:cd19339   98 DKSKKGYGKSDEGWKwGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCHGVSGSCTTKT 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 194 CWLQLPEFREVGAHLKEKYHAALKVDLLQG--AGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRE 271
Cdd:cd19339  178 CWTTLPSFREIGDYLKKKYERARRVEPVRGrrRRRPTFLKLKISRKYKKPRPRDLVYLEKSPNYCEKDPLTGSLGTVGRR 257
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110735437 272 CLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19339  258 CNRTSTGTD-----GCDLMC--CGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTC 312
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
42-333 6.36e-91

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 274.50  E-value: 6.36e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQ 121
Cdd:cd19344   18 SVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRACSAGNLTDCSCDSRRQGQ 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 122 LGGQGWLWGGCSDNVGFGEAISKQFVDALET-----GQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19344   98 SASEGWKWGGCSDNVDYGIWFARKFVDAPEKserkrSRDVRSLMNLHNNEVGRQAIARLMKVKCRCHGVSGSCEVKTCWK 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAALKV------DLLQGAGNSaagrgaiaDTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGR 270
Cdd:cd19344  178 TMPSFEEVGDFLKQKYENSIQIatkkskRRLRRRERR--------KRKVPISKDELVYIHKSPNYCVRDPKKGILGTSGR 249
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110735437 271 ECLRRGRAlgrweRRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19344  250 ECNRTSTG-----PDSCDLLC--CGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTC 305
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
42-333 6.58e-90

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 272.19  E-value: 6.58e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNC--PERALQLSSHGGLrsANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 119
Cdd:cd19337   24 SVGRGAKLAIEECQYQFRYRRWNCstPDSSSVFGPVTNI--GTREAAFTYAISAAGVVHAIARACREGNLSTCGCSRERR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 120 GQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQD--------ARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTT 191
Cdd:cd19337  102 PKDLPRDWLWGGCGDNIEYGYKFAKEFIDARERETNyprhsrelARVLMNLHNNEAGRRAVYEKARVACKCHGVSGSCSL 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 192 QTCWLQLPEFREVGAHLKEKYHAALKVDLLQgagnsaagRGAIA----DTFRSISTRELVHLEDSPDYCLENKTLGLLGT 267
Cdd:cd19337  182 KTCWRQLAPFREVGDRLKDKYDGAVKVKLNR--------RGTLLrrrnSRFNKPTKDDLVYLDDSPDYCERNPKTGSLGT 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110735437 268 EGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19337  254 KGRECNKTSSGTD-----GCELLC--CGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHIC 312
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
41-333 1.28e-88

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 268.84  E-value: 1.28e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  41 SSVAAGAQSGIEECKYQFAWDRWNCPeraLQLSSHGG------LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 114
Cdd:cd19333   17 HAIARGARMAIKECKWQFRNRRWNCP---TTDSRGGPnvfgkiLNRGCRETAFIYAITSAAVTHSVARACSEGSIESCSC 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 115 DDSRnGQLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTC 194
Cdd:cd19333   94 DYRR-RGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKCHGMSGSCTVKTC 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 195 WLQLPEFREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIAD------TFRSISTRELVHLEDSPDYCLENKTLGLLGTE 268
Cdd:cd19333  173 WMRLPTFRTVGDRLKDRFDGASRVAYGNNGNNRGSRRAKKFLlepenpNHKPPTSKDLVYFEESPNFCEKNPKLGTLGTR 252
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 269 GRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19333  253 GRECNATSIGLD-----GCDLMC--CGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
42-333 1.43e-87

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 266.18  E-value: 1.43e-87
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDdSRNG 120
Cdd:cd19335   27 SVAEGAKLGIQECQHQFRGRRWNCTTIEGDLSVFGPvLDKASRESAFVHAIASAGVAHAVTRACAEGDSTSCGCD-SRHK 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 121 QLGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPE 200
Cdd:cd19335  106 GPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHGLSGSCELKTCWWAQPD 185
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 201 FREVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIA--DTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRA 278
Cdd:cd19335  186 FRKIGDYLKDKYDSASEMVVERHRESRGWVETLRPkyKLFKPPTERDLIYYEESPNFCEPNPETGSFGTRGRECNVTSHG 265
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110735437 279 LgrwerRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19335  266 I-----DGCDLLC--CGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTC 313
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
46-325 1.37e-85

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 261.04  E-value: 1.37e-85
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  46 GAQSGIEECKYQFAWDRWNCP--ERALQLS-SHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQL 122
Cdd:cd19342   31 GIQLAVHECQRQFRDHRWNCSslETKNKNPhTSPILSRGYRETAFAYAISAAGVAHQVARACSLGKLLSCGCDRSRRGKR 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 123 GGQGW-LWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 201
Cdd:cd19342  111 SSGNDwKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKCKCHGMSGSCELKTCWKAAPDF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 202 REVGAHLKEKYHAALKVDLLQGaGNSAAGRGAIADTF-RSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRALG 280
Cdd:cd19342  191 REVGDILKEKYDHATLVDQSNL-NNGARRRRLTRRKRrRRPPKTDLVYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPD 269
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 110735437 281 rwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 325
Cdd:cd19342  270 -----SCDSLC--CGRGYNTVRQTRTERCNCRFHWCCYVVCEKCT 307
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
41-333 8.22e-82

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 251.02  E-value: 8.22e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  41 SSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHggLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDdSR 118
Cdd:cd19343   17 PSVVEAARLTVDTCQEQFADRRWNCSsiELAPNFTPD--LTRGTREQAFVYALSSAALTHTIARACASGALPGCGCG-RL 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 119 NGQLGGQGWLWGGCSDNVGFGEAISKQFVDA-----LETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQT 193
Cdd:cd19343   94 PREPPDGDFKWGGCGDNVRYGLRFAKRFTDApekkkKKKKRQARALMNLHNNRVGRKAVRDSLETQCKCHGVSGSCSVKT 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 194 CWLQLPEFREVGAHLKEKYHAALKVDLLQgAGNSAAGRGAIADtFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECL 273
Cdd:cd19343  174 CWKALPDLSEVASRLKRKYARAVEVVSRK-VGSRRKLVPKSLK-VRPYTKDDLIYLTKSPDYCLPDEKLGSLGTRGRECN 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 274 RRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19343  252 KTSVGSD-----SCDSMC--CGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVC 304
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
42-333 1.96e-77

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 240.21  E-value: 1.96e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGG--LRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 119
Cdd:cd19346   29 SIGEGAKEWIRECQHQFRHHRWNCSTLDRDHTVFGRvmLRSS-REAAFVYAISSAGVVYAITRACSQGELKSCSCDPHKR 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 120 GQLGGQGWLW--GGCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19346  108 GRSHDERGEFdwGGCSDNINYGIKFAKAFVDAKEKKeKDARALMNLHNNRCGRMAVKRFMKLECKCHGVSGSCTLRTCWL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAALKVDLLQ-GAGNSAAGRGaiadtFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRR 275
Cdd:cd19346  188 AMSDFRKTGDYLRKRYNGAVQVTMNQdGTGFTVANKN-----FRKATKTDLVYFENSPDYCVMDKSAGSLGTAGRVCNKS 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 110735437 276 GRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19346  263 SRGTD-----GCEVMC--CGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTC 313
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
42-333 2.54e-77

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 240.22  E-value: 2.54e-77
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  42 SVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGGLRSAnRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRN 119
Cdd:cd19345   29 AIGSGVKEWIAECQHQFRNHRWNCNtlDRDHSLFGRLLLRSS-RESAFVYAISSAGVVFAITRACSQGELKSCSCDPKKK 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 120 GQLGGQGWLWG--GCSDNVGFGEAISKQFVDALE-TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19345  108 GSSKDSKGSFDwgGCSDNIDYGIRFARAFVDAKErKGKDARALMNLHNNRAGRKAVKRFMTLECKCHGVSGSCTVRTCWL 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAALKVDLLQ-GAGNSAAGRgaiadTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRR 275
Cdd:cd19345  188 AMADFRKTGDYLRKKYNGAIQVVMNQdGTGFTVANK-----HFKKPTKNDLVYFENSPDYCVRDRDAGSLGTAGRVCNRT 262
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 110735437 276 GRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19345  263 SRGMD-----GCEVMC--CGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTC 313
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
51-333 8.75e-76

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 235.64  E-value: 8.75e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  51 IEECKYQFAWDRWNCperALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWG 130
Cdd:cd19341   27 VLECQEQFRYERWNC---SLGKYRINLLKKGYKETAFLYAISSAGLTHSVARACSSGRLDRCTCDESFSLEENRQTWLWG 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 131 GCSDNVGFGEAISKQFVDALETG-QDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLK 209
Cdd:cd19341  104 GCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVSGSCTVKTCWKQLAPFNEIGKILK 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 210 EKYHAALKVDLLQ----GAGNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGllGTEGRECLRrgralgrweRR 285
Cdd:cd19341  184 RKYEKAVKVVSENnaatGGSQLRKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRYSP--GTKGRRCLK---------GD 252
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 110735437 286 SCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19341  253 NCDTLC--CGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTC 298
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
43-333 7.87e-73

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 228.78  E-value: 7.87e-73
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  43 VAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQL 122
Cdd:cd19349   31 IGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 123 GGQGWLW-GGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 201
Cdd:cd19349  111 NQEEGWKwGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPKF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 202 REVGAHLKEKYHAALKVDLLQGAGNSAAGRGAIAD--TFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLRRGRal 279
Cdd:cd19349  191 RELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKplSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRMCNKTAQ-- 268
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110735437 280 grwERRSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19349  269 ---QNNGCDLMC--CGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTC 317
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
43-333 2.99e-70

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 221.86  E-value: 2.99e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  43 VAAGAQSGIEECKYQFAWDRWNCPE--------RALQLSShgglrsanRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 114
Cdd:cd19347   25 IGEGAKTGIKECQYQFRHRRWNCSTvdntsvfgRVMQIGS--------RETAFTYAISAAGVVNAVSRACREGELSTCGC 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 115 DDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALE--------TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVS 186
Cdd:cd19347   97 SRAARPKDLPRDWLWGGCGDNLEYGYRFAKEFVDARErekiyqkgSYESARTLMNLHNNEAGRRTVYNLADVACKCHGVS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 187 GSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLlqgagNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLG 266
Cdd:cd19347  177 GSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKL-----NSRGKLVQVNSRFNPPTTLDLVYIDPSPDYCVRNESTGSLG 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110735437 267 TEGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19347  252 TQGRLCNKTSEGMD-----GCELMC--CGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVC 311
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
43-333 1.86e-69

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 219.85  E-value: 1.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  43 VAAGAQSGIEECKYQFAWDRWNCPE--------RALQLSShgglrsanRETAFVHAISSAGVMYTLTRNCSLGDFDNCGC 114
Cdd:cd19348   25 IGEGAKTGIKECQYQFRQRRWNCSTvdntsvfgRVMQIGS--------RETAFTYAVSAAGVVNAISRACREGELSTCGC 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 115 DDSRNGQLGGQGWLWGGCSDNVGFGEAISKQFVDALE--------TGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVS 186
Cdd:cd19348   97 SRAARPKDLPRDWLWGGCGDNVEYGYRFAKEFVDAREreknypkgSEEHARTLMNLQNNEAGRRAVYNLADVACKCHGVS 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 187 GSCTTQTCWLQLPEFREVGAHLKEKYHAALKVDLlqgagNSAAGRGAIADTFRSISTRELVHLEDSPDYCLENKTLGLLG 266
Cdd:cd19348  177 GSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRI-----NRKGKLELVNSRFNPPTAEDLVYIDPSPDYCLRNETTGSLG 251
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110735437 267 TEGRECLRRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19348  252 TQGRLCNKTSEGMD-----GCELMC--CGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVC 311
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
43-333 1.43e-68

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 217.57  E-value: 1.43e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  43 VAAGAQSGIEECKYQFAWDRWNCPERALQLSSHGGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCD-DSRNGQ 121
Cdd:cd19350   31 IGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAITAAGVAHAVTAACSQGNLSNCGCDrEKQGYY 110
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 122 LGGQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 201
Cdd:cd19350  111 NQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCHGVSGSCTTKTCWTTLPKF 190
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 202 REVGAHLKEKYHAALKVDLLQgagnsaAGRGAIADTFRSISTR--------ELVHLEDSPDYCLENKTLGLLGTEGRECL 273
Cdd:cd19350  191 REIGYVLKEKYNAAVQVEVVR------ASRLRQPTFLKIKKRRsyqkpmetDLVYIERSPNYCEEDAATGSVGTQGRLCN 264
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 274 RRGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19350  265 RTSPHTD-----GCDLMC--CGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTC 317
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
40-325 7.71e-61

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 197.13  E-value: 7.71e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  40 SSSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGGLRSAN-RETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDd 116
Cdd:cd19355   25 TASAIQGIQIAIHECQHQFRDHRWNCSslETRNKIPYESVVFSRGfRESAFAYAIAAAGVVHAVSNACAMGKLKACGCD- 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 117 srngqlggqgWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19355  104 ----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKCHGTSGSCQLKTCWQ 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAAlkvdLLQGAGNSAAGR--GAIADTFRSISTRELVHLEDSPDYCLENKTLGLLGTEGRECLR 274
Cdd:cd19355  174 VTPEFRTVGSLLKDRFYVA----TLIKPHNRNTGQlePGHAPHRRRASINDLVYFEKSPDFCEREPRLDSAGTQGRICNK 249
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 110735437 275 RGRALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 325
Cdd:cd19355  250 TSPGMD-----NCESLC--CGRGHNILRQTRSERCNCKFHWCCYVVCEECR 293
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
50-333 9.15e-61

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 197.04  E-value: 9.15e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  50 GIEECKYQFAWDRWNCperalQLSSHGGL-RSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWL 128
Cdd:cd19354   26 GLLECQFQFRSERWNC-----SLEGRGSLlKRGFKETAFLYAVSSAALTHSLAKACSSGRMERCTCDDSPGLENREAWQW 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 129 WGgCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHL 208
Cdd:cd19354  101 GV-CGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSCAVRTCWKQLSPFHETGRLL 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 209 KEKYHAALKVdllQGAGNSAAGRGAIADTFRSISTR--------ELVHLEDSPDYCLENKTlgLLGTEGRECLRRGralg 280
Cdd:cd19354  180 KLKYENAVKV---HSVTNDATGETELWSPERHGHTLkghsprstDLVYLEDSPSFCRPSKY--SPGTAGRTCSRET---- 250
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110735437 281 rwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19354  251 -----NCDSLC--CGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTC 296
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
53-333 1.78e-58

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 191.02  E-value: 1.78e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  53 ECKYQFAWDRWNCPERALQLSSHggLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQLGGQGWLWGgC 132
Cdd:cd19353   29 ECQYQFRFERWNCTLEGRYRASL--LKRGFKETAFLYAISSAGLTHAMAKACSAGRMERCTCDEAPDLENREAWQWGG-C 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 133 SDNVGFGEAISKQFVdALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVGAHLKEKY 212
Cdd:cd19353  106 GDNLKYSNKFVKEFL-GRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSGSCTVRTCWRQLSPFHEIGKQLKQKY 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 213 HAALKVDllqGAGNSAAGRGAIADTFRSIS--------TRELVHLEDSPDYCLENKTLGllGTEGRECLRrgralgrweR 284
Cdd:cd19353  185 ETSLKVG---STTNEATGEGDISPPKKSGAghsdqiprTTDLVYIDDSPSFCLMSRFSP--GTSGRRCYK---------D 250
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 110735437 285 RSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCRRRVTKYFC 333
Cdd:cd19353  251 KNCESIC--CGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTC 297
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
40-325 1.35e-55

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 183.55  E-value: 1.35e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437  40 SSSVAAGAQSGIEECKYQFAWDRWNCP--ERALQLSSHGG-LRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDd 116
Cdd:cd19356   25 TASALQGIQIAIHECQHQLRDQRWNCSslEGGGKLPHDSAiLKRGFRESAFSFSLLAAGVMHSVATACSLGKLRGCGCE- 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 117 srngqlggqgWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWL 196
Cdd:cd19356  104 ----------WEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKCHGTSGSCQFKTCWH 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735437 197 QLPEFREVGAHLKEKYHAALKVDlLQGAGNSAAGRGAiadTFRSIStRELVHLEDSPDYCLENKTLGLLGTEGRECLRRG 276
Cdd:cd19356  174 VTPEFRLVGALLREKFQRAIFIN-SHNKNSGVFLPRL---RPRRLA-RELVYFEKSPDFCERDPAVDSPGTQGRICNKTS 248
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 110735437 277 RALGrwerrSCRRLCgdCGLAVEERRAETVSSCNCKFHWCCAVRCEQCR 325
Cdd:cd19356  249 PGMD-----GCGSLC--CGRGHNILKQTRSERCHCRFHWCCYVLCEECR 290
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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