NCBI Conserved Domain Search

Conserved domains on [gi|110735416|ref|NP_667128|]

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olfactory receptor 1179 [Mus musculus]

Protein Classification

olfactory receptor family 4A protein( domain architecture ID 11610412)

olfactory receptor family 4A protein is an odorant receptor belonging to the G-protein coupled receptor 1 family

Graphical summary

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List of domain hits

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.74e-146

olfactory receptor 4A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4A, 4C, 4P, 4S, 4X and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 412.38 E-value: 1.74e-146

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                        250       260
                 ....*....|....*....|....*.
gi 110735416 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939  242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.74e-146

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 412.38 E-value: 1.74e-146

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                        250       260
                 ....*....|....*....|....*.
gi 110735416 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939  242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-301

9.89e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 132.63 E-value: 9.89e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416   29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  189 N---THRVGLLVVANSGMMGLVTFVVlmwSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYI--RPATT 262
Cdd:pfam13853 161 DikvNNIYGLFVVTSTFGIDSLLIVL---SYGLILRTVLGIASrEGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 110735416  263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKVWC 301
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

Name

Accession

Description

Interval

E-value

7tmA_OR4A-like

cd15939

olfactory receptor 4A and related proteins, member of the class A family of ...

24-289

1.74e-146

Pssm-ID: 320605 [Multi-domain] Cd Length: 267 Bit Score: 412.38 E-value: 1.74e-146

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15939    2 ICFVVFLLIYLATVLGNLLIVVTIKASQTLGSPMYFFLSYLSFIDICYSSTTAPKLIVDLLSERKTISFNGCMTQLFAEH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15939   82 FFGGAEIFLLTVMAYDRYVAICKPLHYTTIMNRRVCGLLVGVAWVGGFLHSTIQILLTLQLPFCGPNVIDHFFCDLFPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15939  162 KLACTDTYVIGLLVVANSGLICLLSFLILLISYIVILYSLRTHSSEGRRKALSTCGSHITVVVLFFVPCIFIYMRPVTTF 241

                        250       260
                 ....*....|....*....|....*.
gi 110735416 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15939  242 PIDKVVAVFYTIITPMLNPLIYTLRN 267

7tmA_OR4-like

cd15226

olfactory receptor family 4 and related proteins, member of the class A family of ...

24-289

2.08e-113

olfactory receptor family 4 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 4 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320354 [Multi-domain] Cd Length: 267 Bit Score: 328.39 E-value: 2.08e-113

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15226    2 FLFVFFSLFYVATVLGNLLIVVTVTSDPHLHSPMYFLLANLSFIDLCLSSFATPKMICDLLREHKTISFGGCMAQIFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15226   82 FFGGSEMVLLIAMAFDRYVAICKPLHYLTIMSPRMCILLVVASWIIGFIHSLSQLAFVVNLPFCGPNVVDSFFCDLPLVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15226  162 KLACTDTYVLELMVVANSGLISLVCFLLLLISYIVILVTVRKHSSGGSSKALSTCSAHITVVVLFFGPCIFIYVWPFSTF 241

                        250       260
                 ....*....|....*....|....*.
gi 110735416 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15226  242 PVDKFLAVFYTVITPLLNPIIYTLRN 267

7tmA_OR

cd13954

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled ...

23-289

9.28e-108

olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320092 [Multi-domain] Cd Length: 270 Bit Score: 314.42 E-value: 9.28e-108

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd13954    1 ILLFVLFLLIYLLTLLGNLLIILLVRLDSRLHTPMYFFLSNLSFLDICYTSVTVPKMLANLLSGDKTISFSGCLTQLYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd13954   81 FSLGGTECFLLAVMAYDRYVAICHPLHYPTIMNKRVCILLAAGSWLIGFLNSLIHTVLISQLPFCGSNVINHFFCDIPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd13954  161 LKLSCSDTSLNELVIFILAGFVGLGSFLLTLVSYIYIISTILKIPsAEGRQKAFSTCASHLTVVSLFYGTIIFMYVRPSS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 262 TYP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd13954  241 SYSsdLDKVVSVFYTVVTPMLNPIIYSLRN 270

7tmA_OR10A-like

cd15225

olfactory receptor subfamily 10A and related proteins, member of the class A family of ...

24-296

9.77e-105

olfactory receptor subfamily 10A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10A, 10C, 10H, 10J, 10V, 10R, 10J, 10W, among others, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320353 Cd Length: 277 Bit Score: 306.69 E-value: 9.77e-105

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15225    2 LLFVVFLLIYLVTLLGNLLIILITKVDPALHTPMYFFLRNLSFLEICYTSVIVPKMLVNLLSEDKTISFLGCATQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15225   82 FLGGTECFLLAAMAYDRYVAICNPLRYTLIMNRRVCLQLVAGSWLSGILVSLGQTTLIFSLPFCGSNEINHFFCDIPPVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15225  162 KLACADTSLNEIAIFVASVLVILVPFLLILVSYIFIISTILKIPsAEGRRKAFSTCSSHLIVVTLFYGCASFTYLRPKSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 Y--PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15225  242 YspETDKLLSLFYTVVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR5-like

cd15230

olfactory receptor family 5 and related proteins, member of the class A family of ...

26-289

3.54e-103

olfactory receptor family 5 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 5, some subfamilies from families 8 and 9, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320358 Cd Length: 270 Bit Score: 302.50 E-value: 3.54e-103

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGN--MIILISITcSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15230    4 FVLFLLIYLITLVGNlgMIVLIRID-SRL-HTPMYFFLSNLSFVDICYSSVITPKMLVNFLSEKKTISFAGCAAQFFFFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15230   82 VFGTTECFLLAAMAYDRYVAICNPLLYTVIMSKRVCIQLVAGSYLCGFVNSIVHTSSTFSLSFCGSNVINHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15230  162 KLSCSDTHINELVLFAFSGFIGLSTLLIILISYLYILITIlRIRSAEGRRKAFSTCASHLTAVSLFYGTLIFMYLRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15230  242 YSldQDKVVSVFYTVVIPMLNPLIYSLRN 270

7tmA_OR5AP2-like

cd15943

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of ...

9-299

9.24e-100

olfactory receptor subfamily 5AP2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AP2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320609 [Multi-domain] Cd Length: 295 Bit Score: 295.04 E-value: 9.24e-100

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416   9 EFILLGLSQNKKIKALCFLMFLFCYIAILGGN--MIILISITcSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVE 86
Cdd:cd15943    1 EFILLGLTDNPELQVILFAVFLVIYLITLVGNlgMIVLIRLD-SRL-HTPMYFFLSHLSFLDLCYSSAITPKMLVNFLAE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  87 RNKISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPF 166
Cdd:cd15943   79 NKTISFTGCAAQMYFFVAFATTECFLLAVMAYDRYVAICNPLLYTVIMSPRVCIQLVAGSYLIGFVNALIQTICTFRLPF 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 167 CGHNEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVV 245
Cdd:cd15943  159 CGSNVINHFFCDVPPLLKLSCSDTHVNEIVLFAFAIFLGIFTSLEILVSYVYILSAIlRIHSSEGRRKAFSTCASHLMAV 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 110735416 246 IFFFVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15943  239 TIFYGTTLFMYLRPSSSYSldQDKVVSVFYTVVIPMLNPLIYSLRNKEVKDALRRI 294

7tmA_OR4D-like

cd15936

olfactory receptor 4D and related proteins, member of the class A family of ...

26-289

5.23e-97

olfactory receptor 4D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320602 [Multi-domain] Cd Length: 267 Bit Score: 286.92 E-value: 5.23e-97

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15936    4 FLVFLLVYLTTWLGNLLIIITVISDPHLHTPMYFLLANLAFLDISFSSVTAPKMLSDLLSQTKTISFNGCMAQMFFFHFT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15936   84 GGAEVFLLSVMAYDRYIAIHKPLHYLTIMNQGVCTGLVAGSWLGGFAHSIVQVALLLQLPFCGPNVLDNFYCDVPQVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYPE 265
Cdd:cd15936  164 ACTDTFLLELLMVSNSGLVTLLIFFILLISYTVILVKIRTHVTEGKRKALSTCASQITVVTLIFVPCIYIYARPFQTFPM 243

                        250       260
                 ....*....|....*....|....
gi 110735416 266 DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15936  244 DKAVSVLYTVITPMLNPMIYTLRN 267

7tmA_OR4E-like

cd15940

olfactory receptor 4E and related proteins, member of the class A family of ...

26-289

3.20e-95

olfactory receptor 4E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4E and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320606 [Multi-domain] Cd Length: 267 Bit Score: 282.41 E-value: 3.20e-95

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15940    4 FMLFLVLYLLTLSGNILIMITIVMDPRLHTPMYFFLSNLSFIDICHSSVTVPKMLSDLLSEEKTISFNGCVTQLFFLHLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15940   84 ACTEIFLLTIMAYDRYVAICNPLHYPTVMNHKVCLWLVAALWLGGTVHSLAQTFLTIRLPYCGPNEIDSFFCDVPPVIKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYPE 265
Cdd:cd15940  164 ACTDTYLIDILIVSNSGLISLVCFVALLGSYIVILVSLRKRSTEGRRKALSTCASHLTVVTLFFGPCIFIYTRPSTSFSE 243

                        250       260
                 ....*....|....*....|....
gi 110735416 266 DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15940  244 DKVVSVFYTVVTPLLNPIIYTLRN 267

7tmA_OR4Q2-like

cd15938

olfactory receptor 4Q2 and related proteins, member of the class A family of ...

23-289

1.01e-93

olfactory receptor 4Q2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320604 [Multi-domain] Cd Length: 265 Bit Score: 278.68 E-value: 1.01e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15938    1 ALLFALFLLAYTMVLVGNLLIMVTVRSDPKLSSPMYFLLGNLSFLDLCYSTVTCPKMLVDFLSQRKAISYEACIAQLFFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15938   81 HFVGAAEMFLLTVMAYDRYVAICKPLHYTTIMSRRLCWVLVAASWAGGFLHSIVQTLLTIQLPFCGPNQVNNFFCDVPPV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAypAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15938  161 IKLACTDTCVTELLMVSNSGLISTVCFVVLVTSYTTILVTIRS--TEGRRKALSTCASHLMVVTLFFGPCIFIYARPFST 238

                        250       260
                 ....*....|....*....|....*..
gi 110735416 263 YPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15938  239 FPVDKHVSVLYNVITPMLNPLIYTLRN 265

7tmA_OR4Q3-like

cd15935

olfactory receptor 4Q3 and related proteins, member of the class A family of ...

24-289

1.62e-93

olfactory receptor 4Q3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 4Q3 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320601 [Multi-domain] Cd Length: 268 Bit Score: 278.19 E-value: 1.62e-93

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITC-SQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15935    2 LLFVLVLACYAAILLGNLLIVVTVHAdPHLLQSPMYFFLANLSLIDMTLGSVAVPKVLADLLTCGRTISFGGCMAQLFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15935   82 HFLGGSEMLLLTLMAYDRYVAICHPLRYLAVMNRQLCIKLLAACWAGGFLHSATQAALVLRLPFCGPNELDNFYCDVPQV 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15935  162 IKLACMDTYVVEVLMVANSGLLSLVCFLVLLVSYGIILTTLRGRFREGGGKALSTCSSHLTVVSLIFVPCIFVYLRPFSS 241

                        250       260
                 ....*....|....*....|....*..
gi 110735416 263 YPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15935  242 SSVDKVASVFYTLITPALNPLIYTLRN 268

7tmA_OR8S1-like

cd15229

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of ...

26-296

2.45e-91

olfactory receptor subfamily 8S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 8S1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320357 [Multi-domain] Cd Length: 277 Bit Score: 272.93 E-value: 2.45e-91

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15229    4 FLVFLVIYLLTLLGNLLIMLVIRADSHLHTPMYFFLSHLSFLDICYSSVTVPKMLENLLSERKTISVEGCIAQIFFFFFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15229   84 AGTEAFLLSAMAYDRYAAICHPLHYVQIMSKQVCVQLVGGAWALGFLYALINTLLLLNLHFCGPNEINHFSCELPSLLPL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY- 263
Cdd:cd15229  164 SCSDTFANKMVLLTSSVIFGLGSFLLTLVSYIHIISTIlRIRSAEGRSKAFSTCSSHLTVVGLFYGTGFFRYLRPNSASs 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 264 -PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15229  244 sVLDRVFSIQYSILTPMLNPIIYSLKNKEVKAAL 277

7tmA_OR1A-like

cd15235

olfactory receptor subfamily 1A and related proteins, member of the class A family of ...

24-296

1.22e-90

olfactory receptor subfamily 1A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1A, 1B, 1K, 1L, 1Q and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320363 [Multi-domain] Cd Length: 278 Bit Score: 271.02 E-value: 1.22e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15235    3 LLFLLFLAMYLLTLLGNLLIVLLIRSDPRLHTPMYFFLSHLSLVDICFTSTTVPKMLANLLSGSKTISYAGCLAQMYFFI 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15235   83 AFGNTDSFLLAVMAYDRYVAICHPLHYATVMSPKRCLLLVAGSWLLSHLHSLLHTLLMSRLSFCGSNEIPHFFCDLQPLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15235  163 KLSCSDTSLNELLIFTEGAVVVLGPFLLIVLSYARILAAVLKVPsAAGRRKAFSTCGSHLTVVALFYGTIIGVYFQPSSS 242

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15235  243 YSadKDRVATVMYTVVTPMLNPFIYSLRNKDVKGAL 278

7tmA_OR5AK3-like

cd15408

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of ...

10-293

1.48e-90

olfactory receptor subfamily 5AK3, 5AU1, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AK3, 5AU1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320530 Cd Length: 287 Bit Score: 271.12 E-value: 1.48e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  10 FILLGLSQNKKIKALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK 89
Cdd:cd15408    1 FILLGFTDQPELQVLLFVVFLLIYVITLVGNLGMILLIRLDSRLHTPMYFFLSHLSFLDICYSSTITPKTLLNLLAERKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  90 ISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGH 169
Cdd:cd15408   81 ISFTGCLTQLYFYAVFATTECYLLAAMAYDRYVAICNPLLYTVIMSQRVCVSLVAGSYLAGFLNSTVHTGFILRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 170 NEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFF 248
Cdd:cd15408  161 NVINHFFCDGPPLLALSCSDTSLNEMLLFAFVGFNVLTTTLVILISYTYILATIlRMRSAEGRHKAFSTCASHLTAVTLF 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 110735416 249 FVPVLFIYIRPATTYPE--DKVFALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15408  241 YGSLAFMYLRPSSRYSLdlDKVASVFYTVVIPMLNPLIYSLRNKEVK 287

7tmA_OR5V1-like

cd15231

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of ...

24-296

2.48e-90

olfactory receptor subfamily 5V1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5V1 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320359 [Multi-domain] Cd Length: 277 Bit Score: 270.29 E-value: 2.48e-90

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15231    2 LLFLIFLIIYLVTLLGNLLIITLVLLDSHLHTPMYFFLSNLSFLDICYTSVTVPKMLVNLLRERKTISYIGCLAQLFFFV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15231   82 SFVGTECLLLAVMAYDRYVAICNPLHYAVIMSRKVCLQLAAASWLCGFLNSAVHTVLTFRLSFCGSNQISHFFCDIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15231  162 KLSCSDTSLNEVLLLVASVFIGLTPFLFIVISYVYIISTIlKIRSAEGRRKAFSTCASHLTVVTLFYGTAIFNYNRPSSG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15231  242 YSldKDTLISVLYSIVTPMLNPIIYSLRNKEVKGAL 277

7tmA_OR8H-like

cd15411

olfactory receptor subfamily 8H and related proteins, member of the class A family of ...

26-298

3.56e-89

olfactory receptor subfamily 8H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8H, 8I, 5F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320533 [Multi-domain] Cd Length: 279 Bit Score: 267.26 E-value: 3.56e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGN--MIILISITcSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15411    4 FVLFLVIYVITVMGNlgMILLIRAD-SQL-HTPMYFFLSNLSFVDFCYSSTITPKALENFLSGRKAISFAGCFVQMYFFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15411   82 ALATTECFLLGLMAYDRYVAICNPLLYTVVMSRRVCLKLAAGSYAAGFLNSLIHTTLISRLSFCGSNVINHFFCDTPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15411  162 KLSCSDTHVNEMLIFILAGLTLVGSLLIILVSYTYILSTIlKIRSAEGRRKAFSTCASHLTAVTIFYGTGIFTYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110735416 263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15411  242 YSLgqDKVASVFYTVVIPMLNPLIYSLRNKEVKNALRR 279

7tmA_OR5A1-like

cd15417

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of ...

26-298

3.80e-89

olfactory receptor subfamily 5A1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5A1, 5A2, 5AN1, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320539 Cd Length: 279 Bit Score: 267.20 E-value: 3.80e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15417    4 FVLFLGIYLVTLLWNLGLIILIRMDSHLHTPMYFFLSNLSFVDICYSSSITPKMLSDFFREQKTISFVGCATQYFVFSGM 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15417   84 GLTECFLLAAMAYDRYVAICNPLLYSVIMSPRLCVQLVAGAYLGGFLNSLIQTVSMFQLSFCGPNVIDHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNT--HRVGLLVVANsgMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15417  164 SCSDTfiSQVVLFLVAV--LFGVFSVLVVLISYGYIISTIlKIRSAKGRSKAFNTCASHLTAVTLFYGTGLFVYLRPSSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110735416 263 Y--PEDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15417  242 HsqDQDKVASVFYTVVIPMLNPLIYSLRNKEIKDALKR 279

7tmA_OR14-like

cd15227

olfactory receptor family 14 and related proteins, member of the class A family of ...

24-289

5.44e-89

olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320355 Cd Length: 270 Bit Score: 266.63 E-value: 5.44e-89

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15227    2 LHFVLFLLIYLAALTGNLLIITVVTLDHHLHTPMYFFLKNLSFLDLCYISVTVPKSIANSLTNTRSISFLGCVAQVFLFI 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15227   82 FFAASELALLTVMAYDRYVAICHPLHYEVIMNRGACVQMAAASWLSGLLYGALHTANTFSLPFCGSNVIHQFFCDIPQLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15227  162 KLSCSDTYLNEIGVLVLSVCLGLGCFVFIIVSYVHIFSTVLRIPsAQGRSKAFSTCLPHLIVVSLFLSTGSFAYLKPPSD 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15227  242 SPSllDLLLSVFYSVVPPTLNPIIYSLRN 270

7tmA_OR11A-like

cd15911

olfactory receptor subfamily 11A and related proteins, member of the class A family of ...

26-289

3.18e-88

olfactory receptor subfamily 11A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11A and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320577 Cd Length: 270 Bit Score: 264.73 E-value: 3.18e-88

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15911    4 FLLFLVIYIVTMAGNILIIVLVVADRHLHTPMYFFLGNLSCLEICYTSTILPRMLASLLTGDRTISVSGCIVQFYFFGSL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15911   84 AATECYLLAVMSYDRYLAICKPLHYASLMNGRLCLQLAAGSWISGFLASTITVILMSQLTFCGPNEIDHFFCDFAPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAES-RSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15911  164 SCSDTSLVELVTFILSSIVTLPPFLLTLTSYICIISTILRIPSTTgRQKAFSTCSSHLIVVTIFYGTLIIVYVVPSTNTS 243

                        250       260
                 ....*....|....*....|....*..
gi 110735416 265 ED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15911  244 RDlnKVFSLFYTVLTPLVNPLIYSLRN 270

7tmA_OR6C-like

cd15912

olfactory receptor subfamily 6C and related proteins, member of the class A family of ...

24-289

4.93e-87

olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6C, 6X, 6J, 6T, 6V, 6M, 9A, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320578 Cd Length: 270 Bit Score: 261.65 E-value: 4.93e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNM-IILISITCSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15912    2 LLFLLLLLTYLLTLLGNLlIITITLVDHRL-HTPMYFFLRNFSFLEILFTSVVIPKMLANLLSGKKTISFAGCFAQSFFY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15912   81 FFLGTTEFFLLAVMSFDRYVAICNPLHYPTIMNSRVCLQLVLGSWVGGFLLILPPTILVFQLPFCGPNVINHFFCDSGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd15912  161 LKLSCSDTRLIELLDFILASVVLLGSLLLTIVSYIYIISTILRIPsASGRQKAFSTCASHLTVVSIFYGSCIFMYVRPSQ 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 262 TYPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15912  241 SSSLDlnKVVALLNTVVTPLLNPFIYTLRN 270

7tmA_OR5D-like

cd15410

olfactory receptor subfamily 5D and related proteins, member of the class A family of ...

10-299

6.93e-87

olfactory receptor subfamily 5D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5D, 5L, 5W, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320532 Cd Length: 294 Bit Score: 262.21 E-value: 6.93e-87

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  10 FILLGLSQNKKIKALCFLMFLFCYIAILGGN--MIILISITcSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVER 87
Cdd:cd15410    1 FILLGFTDYPELQVPLFLVFLAIYGITLLGNlgMIVLIKID-PKL-HTPMYFFLSHLSFVDFCYSSVIAPKMLVNFLAED 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  88 NKISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFC 167
Cdd:cd15410   79 KAISYSGCMLQFFFFCTFVVTESFLLAVMAYDRYVAICNPLLYTVIMSRKLCVLLVAGSYLWGIVCSLIHTCGLLRLSFC 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 168 GHNEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVI 246
Cdd:cd15410  159 GSNVINHFFCDLPPLLSLSCSDTYLNELLLFIFGSLNEASTLLIILTSYVFIIVTIlRIRSAEGRQKAFSTCASHLTAIT 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110735416 247 FFFVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15410  239 IFHGTILFMYCRPSSSYSldTDKVASVFYTVVIPMLNPLIYSLRNKDVKDALRKL 293

7tmA_OR2T-like

cd15421

olfactory receptor subfamily 2T and related proteins, member of the class A family of ...

26-296

4.20e-86

olfactory receptor subfamily 2T and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 2T, 2M, 2L, 2V, 2Z, 2AE, 2AG, 2AK, 2AJ, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320543 Cd Length: 277 Bit Score: 259.40 E-value: 4.20e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15421    4 FSLILLIFLVALTGNALLILLIWLDSRLHTPMYFLLSQLSLMDLMLISTTVPKMATNFLSGRKSISFVGCGTQIFFFLTL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15421   84 GGAECLLLALMAYDRYVAICHPLRYPVLMSPRVCLLMAAGSWLGGSLNSLIHTVYTMHFPYCGSREIHHFFCEVPALLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY- 263
Cdd:cd15421  164 SCADTSAYETVVYVSGVLFLLIPFSLILASYALILLTVlRMRSAEGRKKALATCSSHLTVVSLYYGPAIFTYMRPGSYHs 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 264 -PEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15421  244 pEQDKVVSVFYTILTPMLNPLIYSLRNKEVLGAL 277

7tmA_OR9K2-like

cd15419

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of ...

23-298

9.07e-86

olfactory receptor subfamily 9K2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 9K2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320541 Cd Length: 279 Bit Score: 258.78 E-value: 9.07e-86

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15419    1 VLLFLLFLVIYMVTVLGNIGMIIIISTDSRLHTPMYFFLMNLSFLDLCYSSVIAPKALANFLSESKTISYNGCAAQFFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15419   81 SLFGTTEGFLLAAMAYDRFIAICNPLLYPVIMSRRVCVQLVAGSYLCGCINSIIQTSFTFSLSFCGSNEIDHFFCDVPPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRP-A 260
Cdd:cd15419  161 LKLSCSDTFINELVMFVLCGLIIVSTILVILVSYAYILSTIlRIPSAEGRKKAFSTCASHLTAVSLFYGTVFFMYAQPgA 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 110735416 261 TTYPE-DKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15419  241 VSSPEqSKVVSVFYTLVIPMLNPLIYSLRNKDVKEALKR 279

7tmA_OR13-like

cd15232

olfactory receptor family 13 and related proteins, member of the class A family of ...

24-289

2.37e-85

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13A1 and 13G1) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320360 [Multi-domain] Cd Length: 270 Bit Score: 257.19 E-value: 2.37e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15232    2 LLFWLFLFLYAAALTGNSLIILAISTSPKLHTPMYFFLVNLSLVDIICTSTVVPKLLQNLLTERKTISFGGCMAQLYFFT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15232   82 WSLGSELLLLTAMAYDRYVAICHPLHYSTIMRKEVCVGLATGVWAIGMLNSAVHTGLMLRLSFCGPNIINHFFCEIPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15232  162 LLSCSDTSLNEIMAFVADVFFGVGNFLLTLTSYGFIIRSIlRIRSTEGKKKAFSTCSSHLIVVSLYYSTVIYTYIRPSSS 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15232  242 YSpeKDKVVAVLYSVVTPTLNPLIYSLRN 270

7tmA_OR1_7-like

cd15918

olfactory receptor families 1, 7, and related proteins, member of the class A family of ...

24-289

2.56e-85

olfactory receptor families 1, 7, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 1 and 7, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320584 [Multi-domain] Cd Length: 270 Bit Score: 257.16 E-value: 2.56e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15918    2 LLFGLFLGMYLVTVLGNLLIILAIGSDSHLHTPMYFFLANLSLVDICFTSTTVPKMLVNIQTQSKSISYAGCLTQMYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15918   82 LFGDLDNFLLAVMAYDRYVAICHPLHYTTIMSPRLCILLVAASWVITNLHSLLHTLLMARLSFCASNEIPHFFCDLNPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15918  162 KLSCSDTHLNELVILVLGGLVGLVPFLCILVSYVRIVSAVLRIPsAGGKWKAFSTCGSHLSVVSLFYGTVIGVYLSPPSS 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15918  242 HSasKDSVAAVMYTVVTPMLNPFIYSLRN 270

7tmA_OR4N-like

cd15937

olfactory receptor 4N, 4M, and related proteins, member of the class A family of ...

24-289

3.15e-85

olfactory receptor 4N, 4M, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 4N, 4M, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320603 Cd Length: 267 Bit Score: 256.97 E-value: 3.15e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15937    2 LLFVLFLLFYLIILPGNILIILTIQGDPQLGSPMYFFLANLALLDICYSSITPPKMLADFFSERKTISYGGCMAQLFFLH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15937   82 FLGAAEMFLLVAMAYDRYVAICKPLHYTTVVNRRVCCVLVGASWAGGFIHSIIQVALIIRLPFCGPNVLDNFFCDITQVI 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15937  162 KLACTNTYTVELLMFSNSGLVILLCFLLLLISYAFLLAKLRTHSSKGKSKAASTCITHIIIVFVMFGPAIYIYARPFRSF 241

                        250       260
                 ....*....|....*....|....*.
gi 110735416 264 PEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15937  242 PMDKVVAVFHTVIFPLLNPMIYTLRN 267

7tmA_OR5P-like

cd15416

olfactory receptor subfamily 5P and related proteins, member of the class A family of ...

26-298

3.18e-85

olfactory receptor subfamily 5P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5P and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320538 [Multi-domain] Cd Length: 279 Bit Score: 257.30 E-value: 3.18e-85

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15416    4 FVLFLVIYSVTLLGNLSIILLIRISSQLHTPMYFFLSHLAFSDICYSSSVTPKMLVNFLVEKTTISYPGCAAQLCSAATF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15416   84 GTVECFLLAAMAYDRYVAICNPLLYSTIMSQKVCVLLVAASYLGGCLNALVFTTCVFSLSFCGPNEINHFFCDFPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15416  164 SCSDIRLAKILPSISSGIIILVTVLTIIISYLYILIAIlRIRSTEGRHKAFSTCASHLTAVTLFYGTITFIYVMPNSSYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 265 ED--KVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15416  244 MDqnKVVSVFYMVVIPMLNPLIYSLRNKEVKGALKR 279

7tmA_OR5C1-like

cd15945

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of ...

10-298

1.91e-84

olfactory receptor subfamily 5C1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5C1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320611 Cd Length: 292 Bit Score: 255.82 E-value: 1.91e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  10 FILLGLSQNKKIKALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK 89
Cdd:cd15945    1 FILLGFTDYLSLKVTLFLVFLLVYLLTLVGNVGMIILIRMDSQLHTPMYYFLSNLSFLDLCYSTAIGPKMLVDLLAKRKS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  90 ISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGH 169
Cdd:cd15945   81 IPFYGCALQMFFFAAFADAECLLLAVMAYDRYVAICNPLLYTTAMSRRVCYLLLVGAYLSGMATSLVHTTLTFRLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 170 NEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFF 248
Cdd:cd15945  161 NTINHFFCDIPPLLALSCSDTQINELLLFALCGFIQTSTFLAIIISYCYIIITVlKIRSAEGRFKAFSTCASHLTAVGLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110735416 249 FVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15945  241 YGTLLFMYLRPSSSYSldTDKMTSVFYTLVIPMLNPLIYSLRNKDVKEALKK 292

7tmA_OR2-like

cd15237

olfactory receptor family 2 and related proteins, member of the class A family of ...

24-289

2.77e-84

olfactory receptor family 2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 2 and 13, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320365 [Multi-domain] Cd Length: 270 Bit Score: 254.51 E-value: 2.77e-84

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15237    3 LFILFLLIYLLTLLGNGLIILLIWLDSRL-HTPMYFFLSNLSLLDICYTTSTVPQMLVHLLSEHKTISFVGCAAQMFFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15237   82 ALGVTECVLLAVMAYDRYVAICNPLRYSVIMSRRVCVRLAATSWASGFLNSLVLTSLTLRLPFCGPNHINHFFCEAPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15237  162 KLACADTSLNEAVIFVTSVLVLLIPFSLILASYIRILATIlRIQSAEGRKKAFSTCASHLTVVTLFYGTAIFMYMRPHST 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15237  242 HSPdqDKMISVFYTIVTPMLNPLIYSLRN 270

7tmA_OR8D-like

cd15406

olfactory receptor subfamily 8D and related proteins, member of the class A family of ...

14-299

1.45e-83

olfactory receptor subfamily 8D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8D and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320528 [Multi-domain] Cd Length: 290 Bit Score: 253.44 E-value: 1.45e-83

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  14 GLSQNKKIKALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYT 93
Cdd:cd15406    1 GLTDQPELQLPLFLLFLGIYVVTVVGNLGMILLITLSSQLHTPMYYFLSNLSFIDLCYSSVITPKMLVNFVSEKNIISYP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  94 SCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMD 173
Cdd:cd15406   81 ECMTQLFFFCVFAIAECYMLTAMAYDRYVAICNPLLYNVTMSPRVCSLLVAGVYIMGLIGATVHTSCMLRLSFCGDNVIN 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 174 HYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPV 252
Cdd:cd15406  161 HYFCDILPLLKLSCSSTYINELLLFIVGGFNVLATTLAILISYAFILSSIlRIRSAEGRSKAFSTCSSHLAAVGVFYGSI 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 110735416 253 LFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15406  241 IFMYLKPSSSSSmtQEKVSSVFYTTVIPMLNPLIYSLRNKDVKNALKKV 289

7tmA_OR8K-like

cd15413

olfactory receptor subfamily 8K and related proteins, member of the class A family of ...

23-298

1.20e-82

olfactory receptor subfamily 8K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8K, 8U, 8J, 5R, 5AL and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320535 Cd Length: 279 Bit Score: 250.70 E-value: 1.20e-82

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGN--MIILISITCSqlIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLF 100
Cdd:cd15413    1 IPLFGLFLVIYLTTVMGNlgMIILTRLDSR--LQTPMYFFLRHLAFVDLGYSTAVTPKMLVNFVVEQNTISFYACATQLA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 101 TMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIY 180
Cdd:cd15413   79 FFLTFIISELFLLSAMAYDRYVAICNPLLYTVIMSQRVCIVLVAIPYLYSFFVALFHTIKTFRLSFCGSNVINHFYCDDL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 181 PLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRP 259
Cdd:cd15413  159 PLLALSCSDTHEKELIILIFAGFNLISSLLIVLVSYLFILSAIlRIRSAEGRQKAFSTCGSHLTVVTIFYGTLIFMYLQP 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 110735416 260 ATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15413  239 KSSHSldTDKMASVFYTLVIPMLNPLIYSLRNKEVKDALKK 279

7tmA_OR12D-like

cd15915

olfactory receptor subfamily 12D and related proteins, member of the class A family of ...

26-289

9.14e-81

olfactory receptor subfamily 12D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 12D and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320581 [Multi-domain] Cd Length: 271 Bit Score: 245.68 E-value: 9.14e-81

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15915    4 FVLFLLLYLASLLGNGAILAVVIAEPRLHSPMYFFLGNLSCLDIFYSSVTVPKMLAGLLSEHKTISFQGCISQLHFFHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15915   84 GSSEAMLLAVMAYDRYVAICNPLRYTVIMNPQVCLLLAVACWVTGFFHALMHTVMTSRLPFCGPNKINHFFCDIKPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI--RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT-- 261
Cdd:cd15915  164 ACGDTSLNLWLLNIVTGSIALGTFILTLLSYIYIISFLllKVRSKEGRHKAFSTCASHLTVVLLLYGPALFTYIRPSSgd 243

                        250       260
                 ....*....|....*....|....*...
gi 110735416 262 TYPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15915  244 SLEQDRIVALLYTVVTPVLNPLIYTLRN 271

7tmA_OR5H-like

cd15409

olfactory receptor subfamily 5H and related proteins, member of the class A family of ...

26-298

4.82e-79

olfactory receptor subfamily 5H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5H, 5K, 5AC, 5T and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320531 [Multi-domain] Cd Length: 279 Bit Score: 241.54 E-value: 4.82e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15409    4 FLVFLAIYLITLVGNLGLIALIWKDSHLHTPMYFFLGNLAFADACTSSSVTPKMLVNFLSKNKMISFSGCAAQFFFFGFS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15409   84 ATTECFLLAAMAYDRYVAICNPLLYPVVMSNRLCVQLITASYIGGFLHSMIHVGLTFRLSFCGSNEINHFFCDIPPLLKI 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15409  164 SCTDPSINELVLFIFSGSIQVFTILTVLISYSYILFTIlKMKSAEGRRKAFSTCGSHLLSVSLFYGSLFFMYVRPSSLYA 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15409  244 ldQDMMDSLFYTIVIPLLNPFIYSLRNKEVIDALRK 279

7tmA_OR2F-like

cd15429

olfactory receptor subfamily 2F and related proteins, member of the class A family of ...

26-296

5.01e-79

olfactory receptor subfamily 2F and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2F and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320546 [Multi-domain] Cd Length: 277 Bit Score: 241.54 E-value: 5.01e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15429    4 FVLFLVMYLLTLLGNFLIILLIRLDPRLHTPMYFFLSHLSFLDICYTTSVVPQMLAHFLAEHKTISFASCVAQLFISLAL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15429   84 GGTEFILLAVMAYDRYVAVCHPLRYTVIMSGGLCIQLAAASWTSGFLNSLVQTAFTFRLPFCGHNTINHFSCELLAVVRL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15429  164 ACVDTSLNEVAILVSSVVVLLTPCFLVLLSYIHIISAIlRIRSSEGRHKAFSTCASHLTVVSLCYGTAIFTYMRPRSGSS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15429  244 alQEKMISLFYAVVTPMLNPLIYSLRNKEVKGAL 277

7tmA_OR2B-like

cd15947

olfactory receptor subfamily 2B and related proteins, member of the class A family of ...

26-289

5.77e-79

olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 2 (subfamilies 2B, 2C, 2G, 2H, 2I, 2J, 2W, 2Y) and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320613 [Multi-domain] Cd Length: 270 Bit Score: 240.99 E-value: 5.77e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNM-IILISITCSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHF 104
Cdd:cd15947    4 FVVVLIFYLLTLLGNTaIILLSLLDPRL-HTPMYFFLSNLSFLDLCFTTSIVPQMLVNLWGPDKTISYGGCVTQLYIFLW 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 105 FGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15947   83 LGSTECVLLAVMAFDRYVAVCRPLHYTVIMHPRLCVQLAALSWLSGLANSLLQTTLTLQLPLCGHHTLDHFFCEVPALIK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 185 LSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTY 263
Cdd:cd15947  163 LACVDTTFNELELFVASVFFLLVPLSLILVSYGFIARAVlRIKSAEGRRKAFGTCSSHLLVVSLFYGTAIYMYLQPPSSY 242

                        250       260
                 ....*....|....*....|....*...
gi 110735416 264 PED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15947  243 SQDqgKFISLFYTVVTPTLNPLIYTLRN 270

7tmA_OR5G-like

cd15414

olfactory receptor subfamily 5G and related proteins, member of the class A family of ...

26-299

8.89e-79

olfactory receptor subfamily 5G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320536 [Multi-domain] Cd Length: 285 Bit Score: 241.18 E-value: 8.89e-79

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15414    4 FLLFLLVYLITLLGNLGMIILIQVDSRLHTPMYFFLSHLSFVDLCYSSVVTPKMLSDFFVEKKAISFLGCAAQMWFFGLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15414   84 VAAECFLLASMAYDRYVAICNPLLYTVIMSQRVCVQLVVGPYVVGLLNTTTHTTAAFFLPFCGPNVINHFFCDIPPLLSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15414  164 SCADTQINKWVLFIMAGALGVLSGLIILVSYIYILIAIlRIRSAEGRRKAFSTCSSHLTAVSILYGTLFFIYVRPSSSSS 243

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15414  244 ldLDKVVSVFYTAVIPMLNPLIYSLRNKEVKDALRRT 280

7tmA_OR5J-like

cd15415

olfactory receptor subfamily 5J and related proteins, member of the class A family of ...

26-298

2.01e-78

olfactory receptor subfamily 5J and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5J and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320537 [Multi-domain] Cd Length: 279 Bit Score: 240.01 E-value: 2.01e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15415    4 FMLFLLIYFITLLGNLGMIVLIRINPQLHTPMYFFLSNLSFVDLCYSSVFAPRLLVNFLVEKKTISYSACIAQHFFFAVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15415   84 VTTEGFLLAVMAYDRYVAICNPLLYTVAMTKRVCVQLVAGSYLGGLINSLTHTIGLLKLSFCGPNVINHYFCDIPPLLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15415  164 SCSDTHINELLLLTFSGVIAMSTLLTIIISYIFILFAIlRIRSAEGRRKAFSTCASHLTAVTLFYGSVSFSYIQPSSQYS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15415  244 leQEKVSAVFYTLVIPMLNPLIYSLRNKDVKDALKR 279

7tmA_OR10G-like

cd15916

olfactory receptor subfamily 10G and related proteins, member of the class A family of ...

23-296

7.42e-78

olfactory receptor subfamily 10G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10G, 10S, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320582 [Multi-domain] Cd Length: 276 Bit Score: 238.50 E-value: 7.42e-78

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK-ISYTSCMAQLFT 101
Cdd:cd15916    1 SLLFLIFLIIYLLTVLGNLLILLTVWVDSHLHRPMYIFLGHLSFLDMWLSTVTVPKMLAGFLEPGGKvISFGGCVAQLYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 102 MHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15916   81 FHFLGSTECFLYTLMAYDRYLAICHPLHYPTIMTGRLCTRLATGTWVAGSLHSAIHTSLTFRLPFCGPNRIDYFFCDIPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPA 260
Cdd:cd15916  161 LLKLACADTTINELVIFASIGVVALGCFILILLSYGNIVRAIlRIRTAEGRRRAFSTCASHLIVVLCFYVPCVFIYLRPG 240

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15916  241 SKEALDGVIAVFYTVVTPLLNPLIYTLRNKEVKTAL 276

7tmA_OR13H-like

cd15431

olfactory receptor subfamily 13H and related proteins, member of the class A family of ...

26-289

7.33e-77

olfactory receptor subfamily 13H and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 13H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320548 [Multi-domain] Cd Length: 269 Bit Score: 235.58 E-value: 7.33e-77

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15431    4 FVLLLIVYLVTLLGNGLIILLIRVDSQLHTPMYFFLSNLSFLDICYTTSSVPQMLVNCLSDRPTISYSRCLAQMYISLFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQsLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15431   84 GITECLLLAVMAYDRFVAICNPLRYTLIMSWRVCIQLAAGSWVSAFLLTVIP-VLTMPLHFCGPNVINHFFCEVQALLKL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15431  163 ACSDTSLNEILMFATSIFTLLLPFSFILVSYIRIGVAVlRIRSAEGRRKAFSTCGSHLTVVTIFYGTAIFMYLRPQSKSS 242

                        250       260
                 ....*....|....*....|....*..
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15431  243 sdQDKIISVFYGVVTPMLNPLIYSLRN 269

7tmA_OR10D-like

cd15228

olfactory receptor subfamily 10D and related proteins, member of the class A family of ...

26-296

1.36e-76

olfactory receptor subfamily 10D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 10D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320356 [Multi-domain] Cd Length: 275 Bit Score: 235.02 E-value: 1.36e-76

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15228    4 FVLFLAFYLCTLLGNLLILSAILSDPRLHTPMYFFLCNLSVFDIGFSSVSTPKMLAYLWGQSRVISLGGCMSQVFFYHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15228   84 GSTECLLYTVMAYDRYVAICHPLRYLLIMNRRVCALLAAGTWITSSFHATILTSLTFTLPYCGSNVVDYFFCDIFPVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15228  164 ACADTSIAETVSFTNVGLVPLTCFLLILASYVRIVISIlKMRSAEGRRKAFSTCSSHLTVVTLFFGPCALIYTQPTPSPV 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 110735416 265 EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15228  244 LVTPVQIFNNVVTPMLNPLIYTLRNKEVKAAL 275

7tmA_OR2A-like

cd15420

olfactory receptor subfamily 2A and related proteins, member of the class A family of ...

24-296

1.56e-75

olfactory receptor subfamily 2A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320542 [Multi-domain] Cd Length: 277 Bit Score: 232.60 E-value: 1.56e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15420    2 LLFGLFSLLYIFTLLGNGLILGLIWLDSRLHTPMYFFLSHLAVVDICYASSTVPHMLGNLLKQRKTISFAGCGTQMYLFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15420   82 ALAHTECVLLAVMSYDRYVAICHPLRYTVIMNWRVCTTLAATSWACGFLLALVHVVLLLRLPFCGPNEVNHFFCEILAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15420  162 KLACADTWINEILIFAGCVFILLGPFSLILISYLHILAAIlKIQSAEGRRKAFSTCSSHLCVVGLFYGTAMFMYMVPGSS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15420  242 NSAeqEKILSLFYSLFNPMLNPLIYSLRNKQVKGAL 277

7tmA_OR6N-like

cd15914

olfactory receptor OR6N and related proteins, member of the class A family of ...

24-289

2.57e-75

olfactory receptor OR6N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6N, 6K, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320580 [Multi-domain] Cd Length: 270 Bit Score: 231.88 E-value: 2.57e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15914    2 LLFILLLLIYLFIITGNLLIFTVVRLDTHLHTPMYFFISILSFLEIWYTTVTIPKMLSNLLSEEKTISFNGCLLQMYFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15914   82 SLGITECYLLTAMAYDRYLAICNPLHYPSIMTPKLCTQLAAGCWLCGFLGPVPEIILISTLPFCGPNQIQHIFCDFPPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15914  162 SLACTDTSLNVLVDFVIHAVIILLTFLLILLSYVKIISVVlKIPSAEGRQKAFSTCAAHLTVVLLFFGSVSFMYLRLSKS 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YPE--DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15914  242 YSLdyDRAIAVVYAVLTPFFNPIIYSLRN 270

7tmA_OR5M-like

cd15412

olfactory receptor subfamily 5M and related proteins, member of the class A family of ...

24-298

6.54e-75

olfactory receptor subfamily 5M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5M and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320534 Cd Length: 279 Bit Score: 231.13 E-value: 6.54e-75

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGN--MIILISITcSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFT 101
Cdd:cd15412    2 LLFVLFLVIYLITLLGNlgMILLIRLD-SRL-HTPMYFFLSHLSFVDLCYSSNVTPKMLVNFLSEKKTISFAGCFTQCYF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 102 MHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15412   80 FIALVITEYYMLAVMAYDRYMAICNPLLYSVKMSRRVCISLVTFPYIYGFLNGLIQTILTFRLSFCGSNVINHFYCADPP 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNTH--RVGLLVVANSGMMGLVTFVVLmwSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIR 258
Cdd:cd15412  160 LIKLSCSDTYvkETAMFIVAGFNLSSSLLIILI--SYLFILIAIlRIRSAEGRCKAFSTCGSHLTAVTIFYGTLFCMYLR 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 110735416 259 PAT--TYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15412  238 PPSeeSVEQSKIVAVFYTFVSPMLNPLIYSLRNKDVKQALKK 279

7tmA_OR5AR1-like

cd15944

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of ...

10-299

5.18e-74

olfactory receptor subfamily 5AR1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5AR1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320610 [Multi-domain] Cd Length: 294 Bit Score: 229.29 E-value: 5.18e-74

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  10 FILLGLSQNKKIKALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK 89
Cdd:cd15944    1 FILLGFTQDPQMQIILFVVFLIIYLVNVVGNLGMIILITTDSQLHTPMYFFLCNLSFCDLGYSSAIAPRMLADFLTKHKV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  90 ISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGH 169
Cdd:cd15944   81 ISFSGCATQFAFFVGFVDAECYVLAAMAYDRYVAICNPLLYSTLMSKRVCLQLMAGSYLAGLVNLVIHTTATFSLSFCGS 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 170 NEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFF 248
Cdd:cd15944  161 NIINHFFCDVPPLLALSCSDTHINEILLYVFCGFVEMSSLSIILISYLFILVAIlRMRSAEGRRKAFSTCASHFTGVTLF 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110735416 249 FVPVLFIYIRPATTYP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15944  241 YGTVIFMYLRPTSVYSldQDKWASVFYTVVIPMLNPLIYSLRNKDVKEAFKKL 293

7tmA_OR5B-like

cd15407

olfactory receptor subfamily 5B and related proteins, member of the class A family of ...

26-298

1.71e-73

olfactory receptor subfamily 5B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 5B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320529 Cd Length: 279 Bit Score: 227.30 E-value: 1.71e-73

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15407    4 FIIFTLIYLITLVGNLGMILLILLDSRLHTPMYFFLSNLSLVDIGYSSAVTPKVMAGLLTGDKVISYNACAAQMFFFVVF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15407   84 ATVENFLLASMAYDRHAAVCKPLHYTTTMTTKVCACLTIGCYVCGFLNASIHTGNTFRLSFCKSNVINHFFCDIPPVLAL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15407  164 SCSDIHISEIVLFFLASFNVFFALLVILISYLFIFITIlRMRSAEGHQKAFSTCASHLTAVSIFYGTVIFMYLQPSSSHS 243

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15407  244 mdTDKMASVFYTMVIPMLNPLVYSLRNKEVKSAFKK 279

7tmA_OR2W-like

cd15434

olfactory receptor subfamily 2W and related proteins, member of the class A family of ...

27-296

2.89e-72

olfactory receptor subfamily 2W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2W and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320551 [Multi-domain] Cd Length: 277 Bit Score: 224.18 E-value: 2.89e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15434    6 VVLIFYLLTLVGNTTIILVSCLDSRL-HTPMYFFLANLSFLDLCFTTSIIPQMLVNLWGPDKTISYVGCAIQLFIALGLG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLS 186
Cdd:cd15434   85 GTECVLLAVMAYDRYAAVCQPLHYTVVMHPRLCWKLVAMSWLIGFGNSLVLSPLTLSLPRCGHHRVDHFFCEMPALIKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 CTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYT-IRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYPE 265
Cdd:cd15434  165 CVDTTAYEATIFALGVFILLFPLSLILVSYGYIARAvLKIKSAAGRKKAFGTCGSHLTVVSLFYGTIIYMYLQPKNSVSQ 244

                        250       260       270
                 ....*....|....*....|....*....|...
gi 110735416 266 D--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15434  245 DqgKFLTLFYTIVTPSLNPLIYTLRNKDVKGAL 277

7tmA_OR13-like

cd15430

olfactory receptor family 13 and related proteins, member of the class A family of ...

23-289

4.83e-72

olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 13 (subfamilies 13C, 13D, 13F, and 13J), some subfamilies from OR family 2 (2K and 2S), and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320547 [Multi-domain] Cd Length: 270 Bit Score: 223.40 E-value: 4.83e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLfcyIAILGGNMIILISITCSQLiEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15430    5 VLCLIMYL---VILLGNGVLIIITILDSHL-HTPMYFFLGNLSFLDICYTSSSVPLMLVNFLSERKTISFSGCAVQMYLS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15430   81 LAMGSTECVLLAVMAYDRYVAICNPLRYPIIMNKRLCVQMAAGSWVTGFLNSLVETVLAMQLPFCGNNVINHFTCEILAV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd15430  161 LKLACVDISLNEIIMLVGNIIFLVIPLLLICISYIFILSTIlRINSAEGRKKAFSTCSAHLTVVIIFYGTILFMYMKPKS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 262 --TYPEDKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15430  241 knAQISDKLITLFYGVVTPMLNPIIYSLRN 270

7tmA_OR6B-like

cd15224

olfactory receptor subfamily 6B and related proteins, member of the class A family of ...

24-289

7.11e-72

olfactory receptor subfamily 6B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 6B, 6A, 6Y, 6P, and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320352 Cd Length: 270 Bit Score: 222.93 E-value: 7.11e-72

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15224    2 LLFLLFLIAYVLTLLENLLIILTIWLNSQLHKPMYFFLSNLSFLEIWYISVTVPKLLAGFLSQNKSISFVGCMTQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15224   82 SLACTECVLLAVMAYDRYVAICHPLRYPVIMTHQLCVQLAAGSWLSGFLISMIKVYFISQLSFCGPNVINHFFCDISPLL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15224  162 NLSCTDMSLAELVDFILALIILLVPLLVTVASYICIISTVLRIPsATGRQKAFSTCASHLTVVIIFYSATLFMYARPKAI 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 YPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15224  242 SSFDsnKLVSVLYTVVTPLLNPIIYCLRN 270

7tmA_OR2B2-like

cd15432

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of ...

26-296

1.46e-70

olfactory receptor subfamily 2B2 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes transmembrane olfactory receptor subfamily 2B2 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320549 [Multi-domain] Cd Length: 277 Bit Score: 220.04 E-value: 1.46e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15432    4 FVVFLIFYILTLLGNLAIILVSRLDPQLHTPMYFFLSNLSLLDLCYTTSTVPQMLVNLRSPQKTISYGGCVAQLFIFLGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15432   84 GSTECVLLAVMAFDRFAAICQPLHYSVIMHQRLCQQLAAGAWISGFANSLVQSTLTLKMPRCGRRRVDHFFCEVPALLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNT--HRVGLLVVanSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15432  164 SCVDTtaNEAELFVI--SVLLLLIPLGLILISYIFIVRAVlRIRSAEGRRKAFNTCGSHLLVVSLFYGTAISMYLQPPSN 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YPED--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15432  242 SSHDrgKMVALFYGIITPMLNPLIYTLRNKDVKEAL 277

7tmA_OR3A-like

cd15233

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of ...

24-296

1.96e-70

olfactory receptor subfamily 3A3 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 3A3 and 3A4, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320361 [Multi-domain] Cd Length: 277 Bit Score: 219.66 E-value: 1.96e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15233    2 VLFVTFLLAYIVTIGGNLSILAAILLEPKLHTPMYFFLGNLSLLDIGCISVTVPQMLVHLLSHKRTISYAACLSQLFFFH 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15233   82 LLAGADCFLLTAMAYDRYLAICQPLTYSVRMSWRVQTALVGISCACAFTNALTHTVAMSTLKFCGPNVINHFFCDLPPLF 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15233  162 QLSCSSTHLNELLLFVFAFFMALAPCVLIVVSYAHVVAAVlRIRSAEGRRKAFSTCGSHLTVVCIFYGTGVFSYMRLGSV 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YP--EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15233  242 YSsdKDKVIGILNTVLSPMLNPLIYSLRNKDVKGAL 277

7tmA_OR2_unk

cd15424

olfactory receptor family 2, unknown subfamily, member of the class A family of ...

24-296

5.84e-70

olfactory receptor family 2, unknown subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents an unknown subfamily, conserved in some mammalia and sauropsids, in family 2 of olfactory receptors. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320544 [Multi-domain] Cd Length: 277 Bit Score: 218.45 E-value: 5.84e-70

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15424    2 LLFVVILIIYLLTILGNLVIIILVQTDSRLHTPMYFFLSHLAGLEICYVTSTLPQMLAHLLAGNGAISFARCTTQMYIAL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15424   82 SLGSTECLLLGAMAYDRYLAICHPLLYAAAMGRWRQLQLALSCWAIGFLLSVINVGCTLRHPFCGPNHINHFFCELPVVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRP--A 260
Cdd:cd15424  162 KLACADTHITEAIVFGAGVLILLVPLSVILTSYGLILASVlQMQSAAGRHKAFSTCASHLAVVTLFYGTVISMYMRPrsG 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15424  242 STPDRDKQIAVFYIVITPLLNPIIYTLRNKDVHGAA 277

7tmA_OR8B-like

cd15405

olfactory receptor subfamily 8B and related proteins, member of the class A family of ...

26-296

1.80e-68

olfactory receptor subfamily 8B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 8B and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320527 [Multi-domain] Cd Length: 277 Bit Score: 214.59 E-value: 1.80e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15405    4 FFLFLGIYVVTVVGNLGLITLICLNSHLHTPMYFFLFNLSFIDLCYSSVFTPKMLMNFVSEKNTISYAGCMTQLFFFCFF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15405   84 VISECYVLTAMAYDRYVAICNPLLYTVTMSPQVCSLLMLGSYVMGFAGAMAHTGCMLRLTFCDSNIINHYMCDILPLLQL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15405  164 SCTSTYVNELVVFVVVGINIIVPSVTIFISYALILSNIlHISSTEGRSKAFSTCSSHIIAVSLFFGSGAFMYLKPSSVGS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 265 --EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15405  244 vnQGKVSSVFYTNVVPMLNPLIYSLRNKDVKLAL 277

7tmA_OR10G6-like

cd15942

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of ...

26-296

1.97e-68

olfactory receptor subfamily 10G6 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10G6 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320608 Cd Length: 275 Bit Score: 214.22 E-value: 1.97e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15942    4 FLFFLVVYLLTLSGNSLIILVVISDLQLHKPMYWFLCHLSILDMAVSTVVVPKVIAGFLSGGRIISFGGCVTQLFFFHFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15942   84 GCAECFLYTVMAYDRFLAICKPLHYSTIMNHRACLCLSLGTWLGGCLHSTFQTSLTFRLPYGQKNEVDYIFCDIPAMLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15942  164 ACADTAFNELVTFIDIGLVAMTCFLLILMSYVYIVSAIlKIPSAEGQRRAFSTCTAHLTVVVIYYVPLTFIYLRPGSQDP 243

                        250       260       270
                 ....*....|....*....|....*....|..
gi 110735416 265 EDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15942  244 LDGVVAVFYTTVTPLLNPVIYTLRNKEMKDAL 275

7tmA_OR10S1-like

cd15941

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of ...

24-296

3.00e-68

olfactory receptor subfamily 10S1 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 10S1 and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320607 [Multi-domain] Cd Length: 277 Bit Score: 213.94 E-value: 3.00e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITC-SQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK-ISYTSCMAQLFT 101
Cdd:cd15941    2 LFFLLFLLIYLLTVLGNLLILLTIGSdPHLHGLPMYHFLGHLSFLDACLSSVTVPKVLAGLLTLSGRtISFEGCVVQLYA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 102 MHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15941   82 FHFLASTECFLYTVMAYDRYLAICHPLHYPTAMNRRMCAGLAGGTWATGATHAAIHTSLTFRLPYCGPCQIAYFFCDIPP 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPA 260
Cdd:cd15941  162 VLKLACADTTINELVILANIGIVAAGCFLLIVISYIYIVAAVlRIRTAEGRQRAFSTCSAHLTGVLLYYVPSVFIYLQPS 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 261 TTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15941  242 SSQAGAGAPAVFYTIVTPMLNPFIYTLRNKEVKRAL 277

7tmA_OR2D-like

cd15428

olfactory receptor subfamily 2D and related proteins, member of the class A family of ...

24-296

5.44e-68

olfactory receptor subfamily 2D and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2D and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320545 [Multi-domain] Cd Length: 277 Bit Score: 213.11 E-value: 5.44e-68

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15428    2 LLFILFLIIYLMTVLGNLLLVLLVIVDSHLHTPMYFFLSNLSVLELCYTTTVVPQMLVHLLSERKIISFIRCAAQLYFFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15428   82 SFGITECALLSVMSYDRYVAICLPLRYSLIMTWKVCISLATGSWVGGLLVSAVDTAFTLNLSFGGHNKINHFLCEMPALL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVvansGMMGLVTFVV----LMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIR 258
Cdd:cd15428  162 KLASTDTHQAEMAM----FIMCVFTLVLpvllILASYTRIIYTVfGMQSLTGRLKAFSTCSSHLMVVSLFYGSVLSTYMR 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 110735416 259 P--ATTYPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15428  238 PksSTSKEYDKMISVFYIIVTPMLNPLIYSLRNKEVKHAL 277

7tmA_OR7-like

cd15234

olfactory receptor family 7 and related proteins, member of the class A family of ...

26-296

2.33e-67

olfactory receptor family 7 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 7 and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320362 [Multi-domain] Cd Length: 277 Bit Score: 211.67 E-value: 2.33e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15234    4 FGLFLSMYLVTVLGNLLIILAVSSDSHLHTPMYFFLSNLSFADICFSSTTVPKMLVNIQTQSKSISYTGCLTQMCFFLLF 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd15234   84 GGLDNFLLAVMAYDRYVAICHPLHYTVIMNPCLCGLLVLLSLLISILDSLLHSLMVLQLSFCTDVEIPHFFCELAQVLKL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15234  164 ACSDTLINNILIYLATVIFGGIPLSGIIFSYYKIVSSILRIPsSGGKYKAFSTCGSHLSVVSLFYGTGLGVYISSAVTHS 243

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 265 EDK--VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15234  244 SRKtaVASVMYTVVTPMLNPFIYSLRNKDMKGAL 277

7tmA_OR9G-like

cd15418

olfactory receptor subfamily 9G and related proteins, member of the class A family of ...

22-299

2.99e-67

olfactory receptor subfamily 9G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 9G and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320540 [Multi-domain] Cd Length: 281 Bit Score: 211.56 E-value: 2.99e-67

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  22 KALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFT 101
Cdd:cd15418    1 QLILFVVFLLSYILTLVGNLTLIALICLDSRLHTPMYFFVGNLSFLDLWYSSVYTPKILADCISKDKSISFAGCAAQFFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 102 MHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15418   81 SAGLAYSECFLLAAMAYDRYVAICNPLLYSSAMSKKLCMGLVAASYLGGFANAIIHTSNTFRLHFCGDNIIDHFFCDLPP 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPA 260
Cdd:cd15418  161 LVKLACDDTRVYELILYFILGFNVIAPTALILASYTFILAAIlRIHSASGRHKAFSTCSAHLTSVTLYYGSILFIYSRPS 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 110735416 261 TTY-PE-DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKV 299
Cdd:cd15418  241 SSHtPDrDKVVALFYTVVNPLLNPLIYSLRNKDVKEALKKL 281

7tmA_OR1330-like

cd15946

olfactory receptor 1330 and related proteins, member of the class A family of ...

24-289

4.28e-66

olfactory receptor 1330 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes olfactory receptors 1330 from mouse, Olr859 from rat, and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320612 Cd Length: 270 Bit Score: 208.10 E-value: 4.28e-66

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15946    2 ILFAVFLLIYLSILLGNGLIITLICLDSRLHTPMYFFLSVLSLLDMSYVTTTVPQMLVHLLSHKKTISFTGCVAQMYIFL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15946   82 ALGITECTLFSVMAYDRYVAICHPLRYKVIMSWGLCILMVAGSWVCGVFSSLLHTFFTMRLPYCGPNEINHYFCEVPAVL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15946  162 KLACADTSLNEMVDFVLGVIVLVVPLSLILASYVNIFKAIlKIRSTQGRCKAFSTCASHITVVTMFYGPAMFMYMRPGSN 241

                        250       260
                 ....*....|....*....|....*....
gi 110735416 263 Y-PE-DKVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15946  242 YsPErDKKISLFYNVFTALLNPVIYSLRN 270

7tmA_OR1E-like

cd15236

olfactory receptor subfamily 1E and related proteins, member of the class A family of ...

23-296

2.30e-62

olfactory receptor subfamily 1E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 1E, 1J, and related proteins in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320364 [Multi-domain] Cd Length: 277 Bit Score: 198.84 E-value: 2.30e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15236    1 GVFFALFLAMYLTTVLGNLLIILLIRLDSHLHTPMYFFLSHLAFTDVSFSSVTVPKMLMNMQTQDQSIPYAGCISQMYFF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15236   81 IFFGCLDSFLLAVMAYDRYVAICHPLHYTAIMRPELCVLLVAGSWVLTCFHALLHTLLLARLSFCADNVIPHFFCDLVAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd15236  161 LKLSCSSTSLNELVIFTEGGLLFVLPLLLILGSYIRIAATILKVPsTKGICKAFSTCGSHLSVVFLYYGTIIGVYFFPSS 240

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110735416 262 TYPEDK--VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15236  241 NNSSDKdiVASVMYTVVTPMLNPFIYSLRNRDIKGAL 277

7tmA_OR11G-like

cd15913

olfactory receptor OR11G and related proteins, member of the class A family of ...

24-289

5.95e-62

olfactory receptor OR11G and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor 11G, 11H, and related proteins in other mammals, and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320579 Cd Length: 270 Bit Score: 197.54 E-value: 5.95e-62

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15913    2 LLFSFFSVIYILTLLGNGAIICAVWWDRRLHTPMYILLGNFSFLEICYVTSTVPNMLVNFLSETKTISFSGCFLQFYFFF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIhSFLQSLLAIS-LPFCGHNEMDHYFCDIYPL 182
Cdd:cd15913   82 SLGTTECFFLSVMAFDRYLAICRPLHYPTIMTGQLCGKLVAFCWVCGFL-WFLIPVVLISqLPFCGPNIIDHFLCDPGPL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYT-IRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd15913  161 LALSCVPAPGTELICYTLSSLIIFGTFLFILGSYTLVLRAvLRVPSAAGRHKAFSTCGSHLAVVSLFYGSVMVMYVSPGS 240

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 262 TYPED--KVFALFYTILAPMFNPLIYTLRN 289
Cdd:cd15913  241 GNSTGmqKIVTLFYSVVTPLLNPLIYSLRN 270

7tmA_OR2Y-like

cd15433

olfactory receptor subfamily 2Y and related proteins, member of the class A family of ...

24-296

1.18e-59

olfactory receptor subfamily 2Y and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 2Y, 2I, and related protein in other mammals. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320550 [Multi-domain] Cd Length: 277 Bit Score: 191.93 E-value: 1.18e-59

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15433    2 VLFVVVLIFYLLTLVGNTIIILLSVRDLRLHTPMYYFLCHLSFVDLCFTTSTVPQLLANLRGPALTITRGGCVAQLFISL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd15433   82 ALGSAECVLLAVMAFDRYAAVCRPLHYAALMSPRLCQTLASISWLSGFVNSVAQTGLLAERPLCGHRLLDHFFCEMPVFL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 184 TLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT 262
Cdd:cd15433  162 KLACGDDETTEVQMFVARVVILLLPAALILGSYGHVAHAVlRIKSSAGRRRAFGTCGSHLMVVFLFYGSAIYTYLQPIHR 241

                        250       260       270
                 ....*....|....*....|....*....|....*.
gi 110735416 263 YPED--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15433  242 YSQAhgKFVSLFYTVMTPALNPLIYTLRNKDVKGAL 277

7tmA_OR56-like

cd15223

olfactory receptor family 56 and related proteins, member of the class A family of ...

23-296

2.06e-57

olfactory receptor family 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 56 and related proteins in other mammals, sauropsids, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320351 [Multi-domain] Cd Length: 279 Bit Score: 185.96 E-value: 2.06e-57

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15223    1 HWLSLPFLLLYLVALVANSLLLLIIKLERSLHQPMYILLGILAAVDIVLATTILPKMLAIFWFDANTISLPGCFAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPL 182
Cdd:cd15223   81 HFFTAMESSILLVMALDRYVAICKPLRYPSIITKSFILKLVLFALIRSGLLVLPIVVLASQLSYCSSNVIEHCYCDHMAL 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 183 LTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYT-IRAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYI--RP 259
Cdd:cd15223  161 VSLACGDTTINSIYGLAVAWLIVGSDIILIFFSYALILRAvLRLASGEARSKALNTCGSHLIVILFFYTAVLVSSLtyRF 240

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 110735416 260 ATTYPED--KVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15223  241 GKTIPPDvhVLLSVLYILIPPALNPIIYGVRTKEIRQGF 279

7tmA_OR51_52-like

cd15917

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of ...

29-292

3.49e-48

olfactory receptor family 51, 52, 56 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor families 51, 52, 56, and related proteins in other mammals, sauropsids, amphibians, and fishes. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341351 Cd Length: 275 Bit Score: 162.07 E-value: 3.49e-48

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15917    7 FCAMYLVALLGNITILFVIKIESSLHEPMYLFLAMLAATDLVLSTSTVPKMLGIFWFNAREISFDACLAQMFFIHSFTAM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15917   87 ESGVLLAMAFDRYVAICYPLRYTTILTNTVVGKIGLAILLRAVALIIPLPLLVRRLPYCGSNVISHSYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NT--HRVGLLVVANSGMMGLVTFVVLmwSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYPE 265
Cdd:cd15917  167 DTrvNSIYGLFVALLIVGFDLLFIAL--SYVLILRAVlQLPSKEARLKALSTCGSHICVILIFYTPALFSFLTHRFGHHV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 110735416 266 DK----VFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15917  245 PPhvhiLLANLYLLLPPMLNPIVYGVRTKQI 275

7tmA_OR52E-like

cd15952

olfactory receptor subfamily 52E and related proteins, member of the class A family of ...

29-292

1.21e-45

olfactory receptor subfamily 52E and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52E and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320618 Cd Length: 274 Bit Score: 155.62 E-value: 1.21e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFC--YIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15952    5 FPFCavYLIALLGNCTILFVIKTEQSLHQPMFYFLAMLSTIDLGLSTATIPKMLGIFWFNLREISFGGCLAQMFFIHTFT 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLS 186
Cdd:cd15952   85 GMESAVLVAMAFDRYVAICNPLRYTTILTNKVISVIALGIVLRPLLLVLPFVFLILRLPFCGHNIIPHTYCEHMGIAKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 CTNTHRVGLLVVANSGMMGLvTFVVLMWSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYI--RPATTY 263
Cdd:cd15952  165 CASIRINIIYGLFAISVLVL-DVILIALSYVLILRAVFRLPShDARLKALSTCGSHVCVILAFYTPALFSFLthRFGHNI 243

                        250       260       270
                 ....*....|....*....|....*....|.
gi 110735416 264 PE--DKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15952  244 PRyiHILLANLYVVLPPMLNPVIYGVRTKQI 274

7tmA_OR52I-like

cd15950

olfactory receptor subfamily 52I and related proteins, member of the class A family of ...

27-288

3.00e-45

olfactory receptor subfamily 52I and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52I and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320616 Cd Length: 275 Bit Score: 154.49 E-value: 3.00e-45

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFC--YIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHF 104
Cdd:cd15950    3 IAIPFCsmYVIALLGNGTILLVIKLDPSLHEPMYYFLCMLAVIDLVMSTSIVPKMLSIFWLGSAEISFEACFTQMFFVHS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 105 FGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15950   83 FTAVESGVLLAMAFDRYVAICHPLRYSAILTSQVIAQIGLAIVLRALLFMTPLTCLVTSLPYCGSRVVPHSYCEHMAVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 185 LSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLF-IYIR--PA 260
Cdd:cd15950  163 LACADPRPSSLYSITGSTLVVGTDSAFIAVSYGLILRAVlGLSSKEARLKAFSTCGSHVCVILLFYIPGLLsIYTQrfGQ 242

                        250       260
                 ....*....|....*....|....*....
gi 110735416 261 TTYPEDKVF-ALFYTILAPMFNPLIYTLR 288
Cdd:cd15950  243 GVPPHTQVLlADLYLLVPPMLNPIIYGMR 271

7tmA_OR52P-like

cd15953

olfactory receptor subfamily 52P and related proteins, member of the class A family of ...

29-291

3.19e-43

olfactory receptor subfamily 52P and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52P and related proteins in other mammals, sauropsids and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 341354 Cd Length: 275 Bit Score: 149.34 E-value: 3.19e-43

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15953    7 FCLMYIVTLLGNCTILFVVGKEQSLHKPMYLLLCMLALTDLVLSTSVVPKALCIFWFNLKEITFSGCLTQMFFIHTLSIM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15953   87 ESAVLVAMAFDRYVAICNPLRYATILTNSRIAKLGLVGLIRGVLLILPLPLLLSRLPFCANRIIPHTYCEHMAVVKLACG 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NT--HRVGLLVVANSGMMGLVTFVVLmwSYYFILYTI-RAYPAESRSKALSTCSSHVTVVIFFFVPVLFIYI--RPATTY 263
Cdd:cd15953  167 DTtiNRIYGLVVALLVVGLDLLLIAL--SYALIIRAVlRLSSKKARQKALNTCTAHICVILMSYTPALFSFLthRFGQGI 244

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 264 PE--DKVFALFYTILAPMFNPLIYTLRNTE 291
Cdd:cd15953  245 APhiHIILANLYLLVPPMLNPIIYGVKTKE 274

7tmA_OR52B-like

cd15221

olfactory receptor subfamily 52B and related proteins, member of the class A family of ...

29-288

5.31e-42

olfactory receptor subfamily 52B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor (OR) subfamilies 52B, 52D, 52H and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320349 Cd Length: 275 Bit Score: 146.28 E-value: 5.31e-42

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15221    7 FCSMYIVALLGNSLLLFVIVTERSLHEPMYLFLSMLAVTDLLLSTTTVPKMLAIFWFGAGEISFDGCLTQMFFVHFVFVT 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15221   87 ESAILLAMAFDRYVAICYPLRYTTILTHSVIGKIGVAAVARSFCIVFPFVFLLKRLPYCGHNVIPHTYCEHMGIARLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NThRV----GLLVVANSGMMGLVTFVVlmwSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYI--RPAT 261
Cdd:cd15221  167 DI-TVniwyGLTVALLTVGLDVVLIAV---SYALILRAVFRLPSkDARLKALSTCGSHVCVILMFYTPAFFSFLthRFGR 242

                        250       260
                 ....*....|....*....|....*....
gi 110735416 262 TYPEDK--VFALFYTILAPMFNPLIYTLR 288
Cdd:cd15221  243 HIPRHVhiLLANLYVLVPPMLNPIVYGVK 271

7tmA_OR51-like

cd15222

olfactory receptor family 51 and related proteins, member of the class A family of ...

29-291

1.05e-41

olfactory receptor family 51 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor family 51 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320350 Cd Length: 275 Bit Score: 145.34 E-value: 1.05e-41

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15222    7 FCLLYLVALLGNSTILFVIKTEPSLHEPMYYFLSMLAVTDLGLSLSTLPTVLGIFWFNAREISFDACLAQMFFIHTFSFM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15222   87 ESSVLLAMAFDRFVAICNPLRYASILTNSRIAKIGLAIVLRSVLLLLPLPFLLKRLPFCHSNVLSHSYCLHQDVMKLACS 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NTHR---VGLLVVANSgmMGL-VTFVVLmwSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPV--LFIYIRPAt 261
Cdd:cd15222  167 DTRVnsiYGLFVVLST--MGLdSLLILL--SYVLILKTVLGIASrEERLKALNTCVSHICAVLIFYVPMigLSMVHRFG- 241

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 110735416 262 typeDKVFALFYTILA-------PMFNPLIYTLRNTE 291
Cdd:cd15222  242 ----KHASPLVHVLMAnvyllvpPVLNPIIYSVKTKQ 274

7tmA_OR52W-like

cd15956

olfactory receptor subfamily 52W and related proteins, member of the class A family of ...

27-292

1.86e-39

olfactory receptor subfamily 52W and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52W and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320622 [Multi-domain] Cd Length: 275 Bit Score: 139.61 E-value: 1.86e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15956    5 LPFCFIYVLSLLGNGVLLSVVWKEHRLHQPMFLFLAMLAATDLVLALSTAPKLLAILWFGATAISSYVCLSQMFLVHAFS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLS 186
Cdd:cd15956   85 AMESGVLVAMALDRFVAICNPLHYATILTLEVVAKAGLLLALRGVAIVIPFPLLVCRLSFCASHTIAHTYCEHMAVVKLA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 CTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYI----RPAT 261
Cdd:cd15956  165 CGATTVDSLYGLALALFIGGGDVLFIAYSYGLIVKTVLRLPSpEARGKAFSTCSAHICVILFFYIPGLLSVLmhrfGHSV 244

                        250       260       270
                 ....*....|....*....|....*....|.
gi 110735416 262 TYPEDKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15956  245 PSAAHVLLSNLYLLLPPALNPIVYGIRTKQI 275

7tmA_OR52R_52L-like

cd15951

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of ...

29-289

3.43e-39

olfactory receptor subfamily 52R, 52L, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamilies 52R, 52L and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320617 Cd Length: 275 Bit Score: 138.63 E-value: 3.43e-39

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15951    7 FCIMYAVALLGNFTILFIVKTEPSLHEPMYLFLCMLAITDLVLSTSTLPKMLSIFWFNSREIDFSACLTQMFFIHSFSTM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15951   87 ESGIFVAMALDRYVAICNPLRHSTILTNSVVAKIGLAVVLRGGILVSPHPFLLRRLPYCRTNIIPHTYCEHMAVVKLACA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NTH---RVGLLVVAnsgMMGLVTFVVLMWSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYIRPATTYP 264
Cdd:cd15951  167 DTRvsrAYGLSVAF---LVGGLDVIFIAVSYIQILRAVFKLPSkEARLKTFGTCGSHICVILVFYIPALFSFLTHRFGHN 243

                        250       260
                 ....*....|....*....|....*....
gi 110735416 265 EDKVFALF----YTILAPMFNPLIYTLRN 289
Cdd:cd15951  244 VPPHVHILianvYLLVPPMLNPIIYGVRT 272

7tm_4

pfam13853

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

29-301

9.89e-37

Olfactory receptor; The members of this family are transmembrane olfactory receptors.

Pssm-ID: 404695 Cd Length: 278 Bit Score: 132.63 E-value: 9.89e-37

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416   29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:pfam13853   1 FCLMYLIIFLGNGTILFVIKTESSLHQPMYLFLAMLALIDLGLSASTLPTVLGIFWFGLREISFEACLTQMFFIHKFSIM 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:pfam13853  81 ESAVLLAMAVDRFVAICSPLRYTTILTNPVISRIGLGVSVRSFILVLPLPFLLRRLPFCGHHVLSHSYCLHMGLARLSCA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  189 N---THRVGLLVVANSGMMGLVTFVVlmwSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIYI--RPATT 262
Cdd:pfam13853 161 DikvNNIYGLFVVTSTFGIDSLLIVL---SYGLILRTVLGIASrEGRLKALNTCGSHVCAVLAFYTPMIGLSMvhRFGHN 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 110735416  263 YPE--DKVFALFYTILAPMFNPLIYTLRNTEMKNALRKVWC 301
Cdd:pfam13853 238 VPPllQIMMANAYLFFPPVLNPIVYSVKTKQIRDCVKRMLL 278

7tmA_OR52M-like

cd15949

olfactory receptor subfamily 52M and related proteins, member of the class A family of ...

8-293

7.25e-36

olfactory receptor subfamily 52M and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52M and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320615 Cd Length: 292 Bit Score: 130.67 E-value: 7.25e-36

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416   8 TEFILLGLSQNKKIKALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVER 87
Cdd:cd15949    2 STFILLGIPGLEPLHVWISIPFCSMYLIAVLGNCTILFIIKSEPSLHQPMYFFLSMLAIIDLVLSTSTMPKLLAIFWFSS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  88 NKISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFC 167
Cdd:cd15949   82 NEIPLHACLLQMFLIHSFSAIESGIFLAMAFDRYVAICNPLRHKTILTNTTVIRIGLAAVIRGVLYISPLPLLVRRLPWY 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 168 GHNEMDHYFCDIYPLLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVI 246
Cdd:cd15949  162 RTNIIAHSYCEHMAVVGLACGDVSINNHYGLTIGFLVLIMDSLFIVLSYIMILRVVQRLAtSEARLKTFGTCVSHVCAIL 241

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 110735416 247 FFFVPV----LFIYIRPATTYPEDKVFALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15949  242 AFYVPIavssLIHRFGQNVPPPTHILLANFYLLIPPMLNPIVYGVRTKQIQ 292

7tmA_OR52K-like

cd15948

olfactory receptor subfamily 52K and related proteins, member of the class A family of ...

29-293

3.43e-34

olfactory receptor subfamily 52K and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52K and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320614 [Multi-domain] Cd Length: 277 Bit Score: 125.79 E-value: 3.43e-34

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15948    8 FCSAFTVALLGNCTLLYVIKTEPSLHEPMFYFLAMLAVIDLVLSTTTVPKILSIFWFNSREINFNACLVQMFFLHSFSIM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCT 188
Cdd:cd15948   88 ESAVLLAMAFDRYVAICNPLRYATILTNSVITKIGLAALARAVTLMTPLPFLLRRLPYCRSHVIAHCYCEHMAVVKLACG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 189 NTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLF---IYIRPATTYP 264
Cdd:cd15948  168 DTRFNNIYGIAVALFIVGLDLMFIILSYVFILRAVLSLASkEEQLKAFGTCGSHICAILVFYTPVVLsstMHRFARHVAP 247

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 265 EDKVF-ALFYTILAPMFNPLIYTLRNTEMK 293
Cdd:cd15948  248 HVHILlANFYLLFPPMMNPIVYGVKTKQIR 277

7tmA_OR52N-like

cd15954

olfactory receptor subfamily 52N and related proteins, member of the class A family of ...

29-292

5.95e-31

olfactory receptor subfamily 52N and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52N and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320620 Cd Length: 276 Bit Score: 117.23 E-value: 5.95e-31

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  29 FLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGI 108
Cdd:cd15954    7 FCFMYIIAMVGNCGLLYLIWIEEALHRPMYYFLSMLSFTDITLCTTMVPKAMCIFWFNLKEISFNACLVQMFFVHTFTGM 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 109 EILILTVMAYDRYVAICKPLHYSIIMSrgrcHAMVTACCAGAFIHSFLQ----SLLAISLPFCGHNEMDHYFCDIYPLLT 184
Cdd:cd15954   87 ESGVLMLMALDRYVAICYPLRYATILT----NPVITKAGLATFLRGVMLiipfPLLTKRLPYCRGNFIPHTYCDHMSVVK 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 185 LSCTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYP-AESRSKALSTCSSHVTVVIFFFVPVLFIYIRPA--- 260
Cdd:cd15954  163 LACANIRVDAIYGLMVALLIGGFDILCISVSYAMILRAVVSLSsKEARSKAFSTCTAHICAIVITYTPAFFTFFAHRfgg 242

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 261 --TTYPEDKVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15954  243 hhITPHIHIIMANLYLLLPPMMNPIVYGVKTKQI 276

7tm_1

pfam00001

7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...

39-285

9.69e-29

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.

Pssm-ID: 459624 [Multi-domain] Cd Length: 256 Bit Score: 110.85 E-value: 9.69e-29

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416   39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNK-ISYTSCMAQLFTMHFFGGIEILILTVMA 117
Cdd:pfam00001   1 GNLLVILVILRNKKLRTPTNIFLLNLAVADLLFSLLTLPFWLVYYLNHGDWpFGSALCKIVGALFVVNGYASILLLTAIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  118 YDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISlpfCGHNEMDHYFCDIYPLLTLSCTNTHRVGLLV 197
Cdd:pfam00001  81 IDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWT---LTVPEGNVTVCFIDFPEDLSKPVSYTLLISV 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  198 VAnsgmmGLVTFVVLMWSYYFILYTIRAYPAESRS--------KALSTCSSHVTVVIFFFVPVLFIYIRPATTYPEDKV- 268
Cdd:pfam00001 158 LG-----FLLPLLVILVCYTLIIRTLRKSASKQKSsertqrrrKALKTLAVVVVVFILCWLPYHIVNLLDSLALDCELSr 232

                         250       260
                  ....*....|....*....|....
gi 110735416  269 -------FALFYTILAPMFNPLIY 285
Cdd:pfam00001 233 lldkalsVTLWLAYVNSCLNPIIY 256

7tmA_OR52A-like

cd15955

olfactory receptor subfamily 52A and related proteins, member of the class A family of ...

25-292

1.23e-23

olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.

Pssm-ID: 320621 [Multi-domain] Cd Length: 276 Bit Score: 97.53 E-value: 1.23e-23

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  25 CFLMFLFCYIAILG--GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd15955    1 HWIGIPFCIMFLLAvlGNCTLLIVIKRERSLHQPMYIFLAMLAATDLGLCPCILPKMLAIFWFQLREISFNACLAQMFFI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAM-VTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYP 181
Cdd:cd15955   81 HTLQAFESGILLAMALDRYVAICHPLRHSSILTPQVLLGIgVLVVVRAVVLIIPCPLLIKLRLHHFRSTVISHSYCEHMA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNT--HRVGLLVVANSGMMGLVTFVVLmwSYYFILYTIRAYPA-ESRSKALSTCSSHVTVVIFFFVPVLFIY-- 256
Cdd:cd15955  161 VVKLAADDVrvNKIYGLFVAFSILGFDIIFITT--SYALIFRAVFRLPQkEARLKAFNTCTAHIFVFLLFYTLAFFSFfa 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 110735416 257 ------IRPATTYpedkVFALFYTILAPMFNPLIYTLRNTEM 292
Cdd:cd15955  239 hrfghhVAPYVHI----LLSNLYLLVPPVLNPIVYGVKTKQI 276

7tm_classA_rhodopsin-like

cd00637

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...

26-289

5.10e-19

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.

Pssm-ID: 410626 [Multi-domain] Cd Length: 275 Bit Score: 84.65 E-value: 5.10e-19

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd00637    2 AVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSVS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACcagafihsFLQSLLAISLPFCGHNEMDHYFCDIYPLLTL 185
Cdd:cd00637   82 LLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALI--------WLLSLLLALPPLLGWGVYDYGGYCCCCLCWP 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SCTNTHRVGLLVVAnsgMMGLVTFVVLMWSYYFILYTIRAYPAESRSKALSTCSSH------------VTVVIFFFV--- 250
Cdd:cd00637  154 DLTLSKAYTIFLFV---LLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRrrrrerkvtktlLIVVVVFLLcwl 230

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 110735416 251 PVLFIYIRPATTYPEDKVFALFYTI------LAPMFNPLIYTLRN 289
Cdd:cd00637  231 PYFILLLLDVFGPDPSPLPRILYFLalllayLNSAINPIIYAFFN 275

7tmA_Opsins_type2_animals

cd14969

type 2 opsins in animals, member of the class A family of seven-transmembrane G ...

23-296

1.73e-12

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.

Pssm-ID: 381741 [Multi-domain] Cd Length: 284 Bit Score: 66.46 E-value: 1.73e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCyIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTM 102
Cdd:cd14969    2 VLAVYLSLIG-VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMSVVGYPLSFYSNLSGRWSFGDPGCVIYGFAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGIEILILTVMAYDRYVAICKPLHYSIImsrGRCHAMVtaCCAGAFIHSFLQSLlaisLPFCGHN----EMDHYFCD 178
Cdd:cd14969   81 TFLGLVSISTLAALAFERYLVIVRPLKAFRL---SKRRALI--LIAFIWLYGLFWAL----PPLFGWSsyvpEGGGTSCS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 179 IYPLLTLSCTNTHRVGLLVVANsgmmgLVTFVVLMWSYYFILYTIRAYPA-------ESRSKALSTCSSHVTVVIFFFVP 251
Cdd:cd14969  152 VDWYSKDPNSLSYIVSLFVFCF-----FLPLAIIIFCYYKIYRTLRKMSKraarrknSAITKRTKKAEKKVAKMVLVMIV 226

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 110735416 252 VLFIYIRP-------ATTYPEDKVFALFYTI------LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14969  227 AFLIAWTPyavvslyVSFGGESTIPPLLATIpalfakSSTIYNPIIYVFMNKQFRRAL 284

7tmA_amine_R-like

cd14967

amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

34-296

3.89e-12

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320098 [Multi-domain] Cd Length: 259 Bit Score: 64.89 E-value: 3.89e-12

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILIL 113
Cdd:cd14967   11 LVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLVMPFSAVYTLLGYWPFGPVLCRFWIALDVLCCTASILNL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 114 TVMAYDRYVAICKPLHYSIIMSRGRCHAMVtaccAGAFIHSFLQSLLAISLpfcghnemDHYFCDIYPLLTLSCTNTHRV 193
Cdd:cd14967   91 CAISLDRYLAITRPLRYRQLMTKKRALIMI----AAVWVYSLLISLPPLVG--------WRDETQPSVVDCECEFTPNKI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 194 GLLVVANSGMMglVTFVVLMWSYYFILYTiraypAESRSKALSTCSshVTVVIF------FFVPVLFIYIRPATTYPeDK 267
Cdd:cd14967  159 YVLVSSVISFF--IPLLIMIVLYARIFRV-----ARRELKAAKTLA--IIVGAFllcwlpFFIIYLVSAFCPPDCVP-PI 228

                        250       260       270
                 ....*....|....*....|....*....|.
gi 110735416 268 VFALFYTI--LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14967  229 LYAVFFWLgyLNSALNPIIYALFNRDFRRAF 259

7tmA_Prostanoid_R

cd14981

G protein-coupled receptors for prostanoids, member of the class A family of ...

27-176

2.75e-07

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.

Pssm-ID: 320112 [Multi-domain] Cd Length: 288 Bit Score: 51.09 E-value: 2.75e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCyiaiLGGNMIILISITCSQLIEQ--PMYFFLNYLALSDLCYTSTVTPKFLtdllvernkISYTS---------- 94
Cdd:cd14981    9 LMFVFG----VLGNLLALIVLARSSKSHKwsVFYRLVAGLAITDLLGILLTSPVVL---------AVYASnfewdggqpl 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  95 CMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAfihsflqsLLAISLPFCGHNEMDH 174
Cdd:cd14981   76 CDYFGFMMSFFGLSSLLIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFA--------LLIASLPLLGLGSYVL 147


                 ..
gi 110735416 175 YF 176
Cdd:cd14981  148 QY 149

7tmA_EDG-like

cd14972

endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...

36-296

8.42e-07

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 341317 [Multi-domain] Cd Length: 275 Bit Score: 49.60 E-value: 8.42e-07

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  36 ILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVernkisytSCMAQLFTMHFFGGIEILILTV 115
Cdd:cd14972   12 IVVENSLVLAAIIKNRRLHKPMYILIANLAAADLLAGIAFVFTFLSVLLV--------SLTPSPATWLLRKGSLVLSLLA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 116 MAY-------DRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIhsflqslLAISLPFCGH-NEMDHYFC-DIYPLLTls 186
Cdd:cd14972   84 SAYsllaiavDRYISIVHGLTYVNNVTNKRVKVLIALVWVWSVL-------LALLPVLGWNcVLCDQESCsPLGPGLP-- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 ctnTHRVGLLVVANSGMMGLVTFV-----VLMWSYYF--ILYTIRAYPAESRskalSTCSSHVTVVIFFFVPV-----LF 254
Cdd:cd14972  155 ---KSYLVLILVFFFIALVIIVFLyvrifWCLWRHANaiAARQEAAVPAQPS----TSRKLAKTVVIVLGVFLvcwlpLL 227

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 110735416 255 IYIRPATTYPEDK------VFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14972  228 ILLVLDVLCPSVCdiqavfYYFLVLALLNSAINPIIYAFRLKEMRRAV 275

7tmA_Octopamine_R

cd15063

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...

24-295

1.21e-06

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.

Pssm-ID: 320191 [Multi-domain] Cd Length: 266 Bit Score: 49.03 E-value: 1.21e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15063    2 ISLLVLTFLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFlqsllaisLPFCGHNEMDHYFCD--IYP 181
Cdd:cd15063   82 WMCTASILNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICF--------PPLVGWNDGKDGIMDysGSS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 182 LLTLSCTNTHRVGLLVVANSGMMGLVTFVVLMwsYYFILYtiRAypAESRSKALSTCSSHVTVVIFFFVPVLFIYIRPAT 261
Cdd:cd15063  154 SLPCTCELTNGRGYVIYSALGSFYIPMLVMLF--FYFRIY--RA--ARMETKAAKTVAIIVGCFIFCWLPFFTVYLVRAF 227

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110735416 262 TYP--EDKVFALFYTI--LAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15063  228 CEDciPPLLFSVFFWLgyCNSALNPCIYALFSRDFRFA 265

7tmA_Parapinopsin

cd15075

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...

24-128

2.32e-06

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.

Pssm-ID: 320203 [Multi-domain] Cd Length: 279 Bit Score: 48.24 E-value: 2.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLiEQPMYFFLNYLALSDLCytstvTPKFLTDLLVERNKISY-----TSCMAQ 98
Cdd:cd15075    3 LSIIMAVFSIASVVLNATVIIVTLRHKQL-RQPLNYALVNLAVADLG-----TTVFGGLLSVVTNAVGYfnlgrVGCVLE 76

                         90       100       110
                 ....*....|....*....|....*....|
gi 110735416  99 LFTMHFFGGIEILILTVMAYDRYVAICKPL 128
Cdd:cd15075   77 GFAVAFFGIAALCTVAVIAVDRLFVVCKPL 106

7tmA_5-HT2B

cd15306

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...

27-298

5.12e-06

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341347 [Multi-domain] Cd Length: 277 Bit Score: 47.13 E-value: 5.12e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERN-KISYTSCMAQLFTMHFF 105
Cdd:cd15306    5 LLILMVIIPTIGGNILVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTILFEAMwPLPLVLCPIWLFLDVLF 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTaccagafIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTl 185
Cdd:cd15306   85 STASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKIT-------VVWLISIGIAIPVPIKGIETDVDNPNNITCVLT- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 sctnTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRSKAlstcSSHVTVVIFFFV----PVLFIYIRPAT 261
Cdd:cd15306  157 ----KERFGDFILFGSLAAFFTPLAIMIVTYFLTIHALRKQTITNEQRA----SKVLGIVFFLFLlmwcPFFITNITSVL 228

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 110735416 262 TYPEDK-VFALFYTI------LAPMFNPLIYTLRNTEMKNALRK 298
Cdd:cd15306  229 CDSCNQtTLQMLMEIfvwigyVSSGVNPLVYTLFNKTFRDAFGR 272

7tmA_Melanopsin

cd15336

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...

34-159

5.21e-06

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320458 [Multi-domain] Cd Length: 290 Bit Score: 47.02 E-value: 5.21e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILG--GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEIL 111
Cdd:cd15336   10 IGITGmlGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTQSPIFFVNSLHKRWIFGEKGCELYAFCGALFGITSMI 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 110735416 112 ILTVMAYDRYVAICKPLHYSIIMSRGRchamVTACCAGAFIHSFLQSL 159
Cdd:cd15336   90 TLLAISLDRYLVITKPLASIRWVSKKR----AMIIILLVWLYSLAWSL 133

7tmA_GPR119_R_insulinotropic_receptor

cd15104

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...

34-296

8.18e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320232 [Multi-domain] Cd Length: 283 Bit Score: 46.60 E-value: 8.18e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILGGNMIILISIT-CSQLIEQPMYFFLNYLALSDLCyTSTVTPKFLTDLLVERNKISY-TSCMAQLFTMHFFGGIEIL 111
Cdd:cd15104   11 PLIITGNLLVIVALLkLIRKKDTKSNCFLLNLAIADFL-VGLAIPGLATDELLSDGENTQkVLCLLRMCFVITSCAASVL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 112 ILTVMAYDRYVAICKPLHYSIIMSrgrcHAMVTACCAGAFIHSFLQSLLAISLPFC---GHNEMDHYFCDIYP--LLTLS 186
Cdd:cd15104   90 SLAAIAFDRYLALKQPLRYKQIMT----GKSAGALIAGLWLYSGLIGFLPLISPQFqqtSYKGKCSFFAAFHPrvLLVLS 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 CTNTHRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRAYPAE---SRSKALSTCSSHVTVVIFFFVPVLFIYIRPATT- 262
Cdd:cd15104  166 CMVFFPALLLFVFCYCDILKIARVHSRAIYKVEHALARQIHPRrtlSDFKAARTVAVLIGCFLLSWLPFQITGLVQALCd 245

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110735416 263 ----YPEDKVFALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15104  246 ecklYDVLEDYLWLLGLCNSLLNPWIYAFWQKEVRRAL 283

7tmA_Opsin5_neuropsin

cd15074

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...

30-152

8.32e-06

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.

Pssm-ID: 320202 [Multi-domain] Cd Length: 284 Bit Score: 46.50 E-value: 8.32e-06

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  30 LFCYIAILGGNMIILISITCSQLIEQPMYFFLNyLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIE 109
Cdd:cd15074    9 VIGILSTLGNGTVLFVLYRRRSKLKPAELLTVN-LAVSDLGISVFGYPLAIISAFAHRWLFGDIGCVFYGFCGFLFGCCS 87

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 110735416 110 ILILTVMAYDRYVAICKPlHYSIIMSRGRCHAMVTACCAGAFI 152
Cdd:cd15074   88 INTLTAISIYRYLKICHP-PYGPKLSRRHVCIVIVAIWLYALF 129

7tmA_Cannabinoid_R

cd15099

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled ...

19-296

1.22e-05

cannabinoid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320227 [Multi-domain] Cd Length: 281 Bit Score: 45.98 E-value: 1.22e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  19 KKIKALCFLMFLFCYIAilggNMIILISITCSQ-LIEQPMYFFLNYLALSDLCYTSTVTPKFLtDLLVERNKISYTSCMA 97
Cdd:cd15099    1 KAIAVLCFLAGPVTFLE----NILVLLTILSSTaLRRRPSYLFIGSLALADMLASVIFTISFL-DFHVFHQRDSRNLFLF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  98 QL--FTMHFFGGIEILILTvmAYDRYVAICKPLHYSIIMSRGRchAMVtaccagAFIHSFLQSLLAISLPFCGHN--EMD 173
Cdd:cd15099   76 KLggVTMAFTASVGSLLLT--ALDRYLCIYQPSNYKLLVTRTR--AKV------AILLMWCVTIIISFLPLMGWRckTWD 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 174 HYFCDIYPLLtlscTNTHRVGLLVVAnsgmmgLVTFVVLMWSYYFILYTIRAYPAESRSKALS----------------- 236
Cdd:cd15099  146 SPCSRLFPYI----DRHYLASWTGLQ------LVLLFLIIYAYPYILWKAHRHEANMGGPKLGrqqvkgqarmrmdirla 215

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110735416 237 -TCSSHVTVVIFFFVPVLFIYIRPATTYPEDKVFALF-----YTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15099  216 kTLSLILLVLAICWLPVLAFMLVDVRVTLTNKQKRMFafcsmLCLVNSCVNPIIYALRSRELRGAM 281

7tmA_Beta3_AR

cd15959

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...

31-156

1.77e-05

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320625 [Multi-domain] Cd Length: 302 Bit Score: 45.67 E-value: 1.77e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  31 FCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCmaQLFTmhffgGIEI 110
Cdd:cd15959    9 LAILVIVGGNLLVIVAIAKTPRLQTMTNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVC--ELWT-----SVDV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110735416 111 LILT-------VMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFL 156
Cdd:cd15959   82 LCVTasietlcAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISFL 134

7tmA_Parietopsin

cd15085

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...

24-128

4.10e-05

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.

Pssm-ID: 320213 [Multi-domain] Cd Length: 280 Bit Score: 44.46 E-value: 4.10e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIeQPMYFFLNYLALSDL----CYTSTVTPKFLTDLLVERNKIsytsCMAQL 99
Cdd:cd15085    3 LSFLMFLNATFSIFNNVLVIAVTLKNPQLR-NPINIFILNLSFSDLmmalCGTTIVTVTNYEGYFYLGDAF----CIFQG 77

                         90       100
                 ....*....|....*....|....*....
gi 110735416 100 FTMHFFGGIEILILTVMAYDRYVAICKPL 128
Cdd:cd15085   78 FAVNYFGIVSLWSLTLLAYERYNVVCKPM 106

7tmA_Beta1_AR

cd15958

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of ...

34-160

6.23e-05

beta-1 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-1 adrenergic receptor (beta-1 adrenoceptor), also known as beta-1 AR, is activated by adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.

Pssm-ID: 320624 [Multi-domain] Cd Length: 298 Bit Score: 43.74 E-value: 6.23e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPkfLTDLLVERNKISYTSCMAQLFTmhffgGIEILIL 113
Cdd:cd15958   12 LLIVAGNVLVIVAIGRTQRLQTLTNLFITSLACADLVMGLLVVP--FGATLVVRGRWLYGSFFCELWT-----SVDVLCV 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110735416 114 T-------VMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFLQSLL 160
Cdd:cd15958   85 TasietlcVIAIDRYLAITSPFRYQSLLTRARAKGIVCTVWAISALVSFLPIMM 138

7tmA_Chemokine_R

cd14984

classical and atypical chemokine receptors, member of the class A family of ...

26-250

7.43e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.

Pssm-ID: 341319 [Multi-domain] Cd Length: 278 Bit Score: 43.36 E-value: 7.43e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  26 FLMFLFCYIAILG--GN-MIILISITCSQLIEQPMYFFLNyLALSDLCYTSTVtPKFLTDLLVErNKISYTSC--MAQLF 100
Cdd:cd14984    2 FLPVLYSLVFLLGlvGNsLVLLVLLYYRKLRSMTDVYLLN-LALADLLFVLTL-PFWAVYAADG-WVFGSFLCklVSALY 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 101 TMHFFGGIeiLILTVMAYDRYVAICKPLHYSiiMSRGRCHAMVTacCAGAFIHSFLQSLLAISLPFCgHNEMDHYFCD-I 179
Cdd:cd14984   79 TINFYSGI--LFLACISIDRYLAIVHAVSAL--RARTLLHGKLT--CLGVWALALLLSLPEFIFSQV-SEENGSSICSyD 151

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110735416 180 YPLLTlscTNTHRVGLLVVANsgMMG-LVTFVVLMWSYYFILYTIRAYPAESRSKALSTCsshVTVVIFFFV 250
Cdd:cd14984  152 YPEDT---ATTWKTLLRLLQN--ILGfLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVI---FAVVVVFFL 215

7tmA_Melanopsin-like

cd15083

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...

27-226

8.44e-05

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320211 [Multi-domain] Cd Length: 291 Bit Score: 43.48 E-value: 8.44e-05

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNyLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15083    6 FILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIIN-LAISDFLMCILNCPLMVISSFSGRWIFGKTGCDMYGFSGGLFG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMvtacCAGAFIHSFLQSLlaisLPFCGHNE--MDHYFC----DIy 180
Cdd:cd15083   85 IMSINTLAAIAVDRYLVITRPMKASVRISHRRALIV----IAVVWLYSLLWVL----PPLFGWSRyvLEGLLTscsfDY- 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 110735416 181 plltLSCTNTHRVGLLVVANSGMmgLVTFVVLMWSYYFILYTIRAY 226
Cdd:cd15083  156 ----LSRDDANRSYVICLLIFGF--VLPLLIIIYCYSFIFRAVRRH 195

7tmA_Peropsin

cd15073

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...

39-296

1.18e-04

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.

Pssm-ID: 320201 [Multi-domain] Cd Length: 280 Bit Score: 42.80 E-value: 1.18e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAY 118
Cdd:cd15073   17 SNGIVLVTFVKFRELRTPTNALIINLAVTDLGVSIIGYPFSAASDLHGSWKFGYAGCQWYAFLNIFFGMASIGLLTVVAV 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 119 DRYVAICKPLHYSiIMSRGRCHAMVTACCAGAFIHSflqsllaiSLPFCGHNEMdhyfcDIYPLLTLSCTNTHRVGLLVV 198
Cdd:cd15073   97 DRYLTICRPDLGR-KMTTNTYTVMILLAWTNAFFWA--------AMPLVGWASY-----ALDPTGATCTINWRKNDSSFV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 199 ANSGMMGLVTFV----VLMWSYYFILYTIRAYPAESRSKALSTCSSH--------VTVVIFFFVP-----VLFIYirpaT 261
Cdd:cd15073  163 SYTMSVIVVNFIvplaVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqndvtkmsVIMIVMFLVAwspysIVCLW----A 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 110735416 262 TYPEDKVFALFYTILAPMF-------NPLIYTLRNTEMKNAL 296
Cdd:cd15073  239 SFGEPKKIPPWMAIIPPLFaksstfyNPCIYVIANKKFRRAI 280

7tmA_tyramine_R-like

cd15061

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...

27-295

1.57e-04

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320189 [Multi-domain] Cd Length: 256 Bit Score: 42.35 E-value: 1.57e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15061    4 SFLILAIIFTIFGNLLVILAVATTRRLRTITNCYIVSLATADLLVGVLVLPLAIIRQLLGYWPLGSHLCDFWISLDVLLC 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYsiIMSRGRCHAMVTACCAgafihsFLQSLLAISLPFCGHNEmdHYFCDIYplltlS 186
Cdd:cd15061   84 TASILNLCCISLDRYFAITYPLKY--RTKRSRRLAITMILAV------WVISLLITSPPLVGPSW--HGRRGLG-----S 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 187 CTNTHRVGLLVVanSGMMGL-VTFVVLMWSYYFILYTIraypaESRSKALSTCSSHVTVVIFFFVPVLFIY-IRPATTYP 264
Cdd:cd15061  149 CYYTYDKGYRIY--SSMGSFfLPLLLMLFVYLRIFRVI-----AKERKTAKTLAIVVGCFIVCWLPFFIMYlIEPFCDCQ 221

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 265 EDKVFALFYTILA---PMFNPLIYTLRNTEMKNA 295
Cdd:cd15061  222 FSEALSTAFTWLGyfnSVINPFIYAFYNKDFRRA 255

7tmA_CB2

cd15341

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G ...

21-296

1.61e-04

cannabinoid receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cannabinoid receptors belong to the class A G-protein coupled receptor superfamily. Two types of cannabinoid receptors, CB1 and CB2, have been identified so far. They are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.

Pssm-ID: 320463 [Multi-domain] Cd Length: 279 Bit Score: 42.52 E-value: 1.61e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  21 IKALCFLMFLFCyiaILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLtDLLVERNKISYTSCMAQL- 99
Cdd:cd15341    3 IAVLCTLCGLLC---ILENVAVLYLILSSPKLRRKPSYLFIGSLALADFLASVVFACSFV-DFHVFHGVDSSAIFLLKLg 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 100 -FTMHFFGGIEILILtvMAYDRYVAICKPLHYSIIMSRGRchAMVTacCAGAFIHSFLQSLlaisLPFCGHN--EMDHYF 176
Cdd:cd15341   79 gVTMSFTASLGSLLL--MAFDRYVCIYYPSEYKALVTRKR--ALVA--LAVMWVLTALIAY----LPLMGWNccPLNSPC 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 177 CDIYPLLtlscTNTHRVGLLVVANSGMMGLV-TFVVLMW-----SYYFILYTIRAYPAESRSKA----LSTCSSHVTVVI 246
Cdd:cd15341  149 SELFPLI----PNDYLLSWLLLVAILLSGIIyTYGHVLWkahkhVVYMEKHQDQQGPGNARMRLdvrlAKTLGLVLAVLL 224

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 110735416 247 FFFVPVLFIYIRPATTYPEDKVFALF-----YTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15341  225 ICWSPVLALMMHSLFTSLSDHIKKAFafcstLCLVNSMVNPIIYALRSRELRSSL 279

7tmA_TAARs

cd15055

trace amine-associated receptors, member of the class A family of seven-transmembrane G ...

24-156

2.29e-04

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320183 [Multi-domain] Cd Length: 285 Bit Score: 42.16 E-value: 2.29e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILG-GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPkFLTDLLVER------------NKI 90
Cdd:cd15055    1 VLLYIVLSSISLLTVlGNLLVIISISHFKQLHTPTNLLLLSLAVADFLVGLLVMP-FSMIRSIETcwyfgdtfcklhSSL 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 110735416  91 SYTSCMAQLFTMhffggieILIltvmAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFL 156
Cdd:cd15055   80 DYILTSASIFNL-------VLI----AIDRYVAVCDPLLYPTKITIRRVKICICLCWFVSALYSSV 134

7tmA_Beta_AR

cd15058

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...

24-138

4.37e-04

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320186 [Multi-domain] Cd Length: 305 Bit Score: 41.28 E-value: 4.37e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCyIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCmaQLFTmh 103
Cdd:cd15058    3 LLLLLALII-LAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMGLLVVPLGATIVVTGKWQLGNFWC--ELWT-- 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 110735416 104 ffgGIEILILT-------VMAYDRYVAICKPLHYSIIMSRGR 138
Cdd:cd15058   78 ---SVDVLCVTasietlcVIAVDRYIAITRPLRYQVLLTKRR 116

7tmA_alpha1A_AR

cd15325

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...

39-138

4.78e-04

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320448 [Multi-domain] Cd Length: 261 Bit Score: 41.03 E-value: 4.78e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAY 118
Cdd:cd15325   17 GNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMSLCIISI 96

                         90       100
                 ....*....|....*....|
gi 110735416 119 DRYVAICKPLHYSIIMSRGR 138
Cdd:cd15325   97 DRYIGVSYPLRYPSIMTERR 116

7tmA_Vasopressin-like

cd14986

vasopressin receptors and its related G protein-coupled receptors, member of the class A ...

24-285

5.32e-04

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.

Pssm-ID: 320117 [Multi-domain] Cd Length: 295 Bit Score: 40.82 E-value: 5.32e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFcyIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYT-STVTPKFLTDLLVE---RNKISYTSCMAQL 99
Cdd:cd14986    4 VAVLGVLF--VFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVAfFTVLTQIIWEATGEwvaGDVLCRIVKYLQV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 100 FTMHffggIEILILTVMAYDRYVAICKPLhySIIMSRGRCHAMVTACCAGAFIHS------FLQSLLAISLPFCghneMD 173
Cdd:cd14986   82 VGLF----ASTYILVSMSLDRYQAIVKPM--SSLKPRKRARLMIVVAWVLSFLFSipqlviFVERELGDGVHQC----WS 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 174 HYFCDIYPLLTLSctnthrVGLLVVAnsgmmgLVTFVVLMWSYYFILYTI---------RAYPAESRSKALSTCSSH--- 241
Cdd:cd14986  152 SFYTPWQRKVYIT------WLATYVF------VIPLIILSYCYGRILRTIwirsrqktdRPIAPTAMSCRSVSCVSSrvs 219

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 110735416 242 -----------VTVVI----------FFFVPVLFIY----IRPATTYPEDKVFALFYTilapMFNPLIY 285
Cdd:cd14986  220 lisrakiktikMTLVIilafilcwtpYFIVQLLDVYagmqQLENDAYVVSETLASLNS----ALNPLIY 284

7tmA_Trissin_R

cd15012

trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...

27-128

5.69e-04

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320140 [Multi-domain] Cd Length: 277 Bit Score: 40.89 E-value: 5.69e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15012    4 ILYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIFCVLQNLSIYLIPSWPFGEVLCRMYQFVHSLSY 83

                         90       100
                 ....*....|....*....|..
gi 110735416 107 GIEILILTVMAYDRYVAICKPL 128
Cdd:cd15012   84 TASIGILVVISVERYIAILHPL 105

7tmA_Opioid_R-like

cd14970

opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...

32-285

6.65e-04

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.

Pssm-ID: 320101 [Multi-domain] Cd Length: 282 Bit Score: 40.74 E-value: 6.65e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  32 CYIAILGGNMIILISITCSQLIEQPMYFFLNyLALSDLCYTSTVtPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEIL 111
Cdd:cd14970   11 CVVGLTGNSLVIYVILRYSKMKTVTNIYILN-LAVADELFLLGL-PFLATSYLLGYWPFGEVMCKIVLSVDAYNMFTSIF 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 112 ILTVMAYDRYVAICKPlhysIIMSRGRCHAMVTACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCdiypLLTLSCTNTH 191
Cdd:cd14970   89 CLTVMSVDRYLAVVHP----VKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTISC----NLQWPDPPDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 192 RVGLLVVANSGMMGLVTFVVLMWSYYFILYTIRA----YPAESRSKALST--CSSHVTVVIFFFV----PV-LFIYIRPA 260
Cdd:cd14970  161 WGRVFTIYTFVLGFAVPLLVITVCYSLIIRRLRSsrnlSTSGAREKRRARrkVTRLVLVVVAVFVvcwlPFhVFQIVRLL 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 110735416 261 TTYPEDKVF-ALFYTILAPMF-----NPLIY 285
Cdd:cd14970  241 IDPPETLTVvGVFLFCIALSYansclNPILY 271

7tmA_5-HT2A

cd15304

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...

27-145

8.34e-04

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341345 [Multi-domain] Cd Length: 267 Bit Score: 40.30 E-value: 8.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTP-KFLTDLLVERNKISYTSCMAQLFTMHFF 105
Cdd:cd15304    5 LLTVIVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPvSMLTILYGYRWPLPSKLCAVWIYLDVLF 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTA 145
Cdd:cd15304   85 STASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIA 124

7tmA_S1PR

cd15102

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G ...

40-296

8.34e-04

sphingosine-1-phosphate receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).

Pssm-ID: 320230 [Multi-domain] Cd Length: 270 Bit Score: 40.15 E-value: 8.34e-04

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  40 NMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERnKISYTSCMAQLFTMHFFGGIEILILTVMAYD 119
Cdd:cd15102   18 NLLVLIAIWRHMKFHRPMYYFLGNLALSDLLAGAAYLANILLSGARTL-RLSPAQWFLREGSMFVALSASVFSLLAIAIE 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 120 RYVAICKPLHYSiIMSRGRCHAMVTACcagafihsFLQSLLAISLPFCGHNEMDHyFCDIYPLLTLscTNTHRVGLLVVA 199
Cdd:cd15102   97 RHLTMAKMKPYG-ASKTSRVLLLIGAC--------WLISLLLGGLPILGWNCLGA-LDACSTVLPL--YSKHYVLFCVTI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 200 NSGMmgLVTFVVLMWSYYFILYT--IRAYPAESRSKALSTCSSHVTVVIFF-------FVPVLFIYIRPATT----YPED 266
Cdd:cd15102  165 FAGI--LAAIVALYARIYCLVRAsgRKATRASASPRSLALLKTVLIVLLVFiacwgplFILLLLDVACPVKTcpilYKAD 242

                        250       260       270
                 ....*....|....*....|....*....|
gi 110735416 267 KVFALfyTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15102  243 WFLAL--AVLNSALNPIIYTLRSRELRRAV 270

7tmA_5-HT7

cd15329

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...

23-146

1.17e-03

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320452 [Multi-domain] Cd Length: 260 Bit Score: 39.95 E-value: 1.17e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVER---NKIS---YTSCM 96
Cdd:cd15329    1 VLIGIVLLIIILGTVVGNALVIIAVCLVKKLRTPSNYLIVSLAVSDLLVALLVMPLAIIYELSGYwpfGEILcdvWISFD 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 110735416  97 AQLFTMhffggiEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTAC 146
Cdd:cd15329   81 VLLCTA------SILNLCAISVDRYLVITRPLTYAVKRTPKRMALMIAIV 124

7tmA_purinoceptor-like

cd14982

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...

64-251

1.20e-03

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341318 [Multi-domain] Cd Length: 283 Bit Score: 39.94 E-value: 1.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  64 LALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAYDRYVAICKPLHYSIImsRGRCHAMv 143
Cdd:cd14982   42 LALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYGSILFLTCISVDRYLAVVHPLKSRRL--RRKRYAV- 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 144 tACCAGAFIHSFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCTNTHRVGLLVVansgmMGLVTFVVLMWSYYFILYTI 223
Cdd:cd14982  119 -GVCAGVWILVLVASVPLLLLRSTIAKENNSTTCFEFLSEWLASAAPIVLIALVV-----GFLIPLLIILVCYSLIIRAL 192

                        170       180       190
                 ....*....|....*....|....*....|...
gi 110735416 224 RAYPAES-----RSKALSTCSSHVTVVIFFFVP 251
Cdd:cd14982  193 RRRSKQSqksvrKRKALRMILIVLAVFLVCFLP 225

7tmA_alpha1B_AR

cd15326

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...

24-138

1.58e-03

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320449 [Multi-domain] Cd Length: 261 Bit Score: 39.49 E-value: 1.58e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGgNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15326    3 LGLVLGAFILFAIVG-NILVILSVVCNRHLRIPTNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDV 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGR 138
Cdd:cd15326   82 LCCTASILSLCAISIDRYIGVRHSLQYPTIVTRKR 116

7tmA_Adenosine_R

cd14968

adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...

34-296

1.60e-03

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.

Pssm-ID: 341316 [Multi-domain] Cd Length: 285 Bit Score: 39.55 E-value: 1.60e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILG--GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPkfLTDLLVERNKISYTSCMAQLFTMHFFGGIEIL 111
Cdd:cd14968   10 IAVLSvlGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVGALAIP--LAILISLGLPTNFHGCLFMACLVLVLTQSSIF 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 112 ILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSFlqsllaisLPFCGHNeMDHYFCDIYPLLTLSC--TN 189
Cdd:cd14968   88 SLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGL--------TPMFGWN-NGAPLESGCGEGGIQClfEE 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 190 THRVGLLVVANSGMMGLVTFVVLMWSYYFILYTIR------------AYPAESRSKALSTCSSHVTVVIFFFVPVLFIYI 257
Cdd:cd14968  159 VIPMDYMVYFNFFACVLVPLLIMLVIYLRIFRVIRkqlrqiesllrsRRSRSTLQKEVKAAKSLAIILFLFALCWLPLHI 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 110735416 258 RPATTY--PEDKV------FALFYTILAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd14968  239 INCITLfcPECKVpkiltyIAILLSHANSAVNPIVYAYRIRKFRQTF 285

7tmA_Vasopressin_Oxytocin

cd15196

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...

31-159

1.89e-03

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.

Pssm-ID: 320324 [Multi-domain] Cd Length: 264 Bit Score: 39.14 E-value: 1.89e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  31 FCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYT---------STVTPKFLTDLLVERnKISYtscmAQLFT 101
Cdd:cd15196    9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLVAlfnvlpqliWDITYRFYGGDLLCR-LVKY----LQVVG 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 110735416 102 MHffggIEILILTVMAYDRYVAICKPLHySIIMSRGRCHAMVtaccAGAFIHSFLQSL 159
Cdd:cd15196   84 MY----ASSYVLVATAIDRYIAICHPLS-SHRWTSRRVHLMV----AIAWVLSLLLSI 132

7tmA_5-HT2C

cd15305

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...

27-138

2.35e-03

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 341346 [Multi-domain] Cd Length: 275 Bit Score: 39.12 E-value: 2.35e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERN-KISYTSCMAQLFTMHFF 105
Cdd:cd15305    5 LLILIIIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLIAILYDYAwPLPRYLCPIWISLDVLF 84

                         90       100       110
                 ....*....|....*....|....*....|...
gi 110735416 106 GGIEILILTVMAYDRYVAICKPLHYSIIMSRGR 138
Cdd:cd15305   85 STASIMHLCAISLDRYVAIRNPIEHSRFNSRTK 117

7tmA_FMRFamide_R-like

cd14978

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...

34-183

2.59e-03

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.

Pssm-ID: 410630 [Multi-domain] Cd Length: 299 Bit Score: 38.77 E-value: 2.59e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILG--GNMIILISITcSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQL-----FTMHFFG 106
Cdd:cd14978   10 ICIFGiiGNILNLVVLT-RKSMRSSTNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYFlpyiyPLANTFQ 88

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFIHSfLQSLLAISLPFCGHNEMDHYFCDIYPLL 183
Cdd:cd14978   89 TASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLN-LPRFFEYEVVECENCNNNSYYYVIPTLL 164

7tmA_NPSR

cd15197

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...

24-159

2.66e-03

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).

Pssm-ID: 320325 [Multi-domain] Cd Length: 294 Bit Score: 38.94 E-value: 2.66e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFcyIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCytsTVTPKFLTDlLVERNKISYTSCMAQLFTMH 103
Cdd:cd15197    4 LATLWVLF--VFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLC---VGLINVLTD-IIWRITVEWRAGDFACKVIR 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 104 FFGGIEI----LILTVMAYDRYVAICKPLHYSiiMSRGRCHAMVtaccAGAFIHSFLQSL 159
Cdd:cd15197   78 YLQVVVTyastYVLVALSIDRYDAICHPMNFS--QSGRQARVLI----CVAWILSALFSI 131

7tmA_Opsin_Gq_invertebrates

cd15337

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...

34-144

2.69e-03

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320459 [Multi-domain] Cd Length: 292 Bit Score: 38.84 E-value: 2.69e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  34 IAILGGNMIILISITCSQLIEQPMYFFLNyLALSDLCYTSTVTPKFLTDLLVERNKI-SYTSCMAQLFTMHFFGGIEILI 112
Cdd:cd15337   13 LGVIGNLLVIYLFSKTKSLRTPSNMFIIN-LAISDFGFSAVNGFPLKTISSFNKKWIwGKVACELYGFAGGIFGFMSITT 91

                         90       100       110
                 ....*....|....*....|....*....|..
gi 110735416 113 LTVMAYDRYVAICKPLHYSIIMSRGRCHAMVT 144
Cdd:cd15337   92 LAAISIDRYLVIAKPLEAMKKMTFKRAFIMII 123

7tmA_Pinopsin

cd15084

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...

27-301

2.99e-03

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320212 [Multi-domain] Cd Length: 295 Bit Score: 38.69 E-value: 2.99e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISItCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15084   16 LMGMVVALASFVNGLVIVVSI-KYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGKTMCEFEGFMVSLTG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRgrcHAMVTacCAGAFIHSFLQSllaiSLPFCGhnemdhyFCDIYPL-LTL 185
Cdd:cd15084   95 IVGLWSLAILAFERYLVICKPMGDFRFQQR---HAVSG--CAFTWGWSLLWT----SPPLFG-------WSSYVPEgLRT 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 SC----------TNTHRVGLLVVANSGMMGLVTFvvlmwSYYFILYTIRAYPAESR-SKALSTCSSHVTVVIFFFVPVLF 254
Cdd:cd15084  159 SCgpnwytggtnNNSYILALFVTCFALPLSTIIF-----SYSNLLLTLRAVAAQQKeSETTQRAEKEVTRMVIAMVMAFL 233

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 255 IYIRPATTY-------------PEDKVFALFYTILAPMFNPLIYTLRNTEMKNALRKVWC 301
Cdd:cd15084  234 ICWLPYATFamvvatnkdvviqPTLASLPSYFSKTATVYNPIIYVFMNKQFRSCLLELLC 293

7tmA_GPR101

cd15215

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...

27-158

3.33e-03

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.

Pssm-ID: 320343 [Multi-domain] Cd Length: 261 Bit Score: 38.29 E-value: 3.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  27 LMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNYLaLSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFG 106
Cdd:cd15215    5 LIVIFLCASLFGNIVLLLVFQRKPQLLQVANRFIFNLL-VADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFA 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110735416 107 GIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVtaccAGAFIHSFLQS 158
Cdd:cd15215   84 FAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRGYLLI----YGTWIVSVLQS 131

7tmA_DmOct-betaAR-like

cd15066

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...

21-145

4.03e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.

Pssm-ID: 320194 [Multi-domain] Cd Length: 265 Bit Score: 38.13 E-value: 4.03e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  21 IKALCFLMFLfcyIAILGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLF 100
Cdd:cd15066    1 LKGFAMTLII---LAAIFGNLLVIISVMRHRKLRVITNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNS 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 110735416 101 TMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTA 145
Cdd:cd15066   78 LDVYFSTASILHLCCISVDRYYAIVQPLEYPSKMTKRRVAIMLAN 122

7tmA_alpha1D_AR

cd15327

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...

30-296

4.49e-03

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.

Pssm-ID: 320450 [Multi-domain] Cd Length: 261 Bit Score: 37.97 E-value: 4.49e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  30 LFCYIAILGgNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIE 109
Cdd:cd15327    9 IFILMAIVG-NILVILSVACNRHLQTVTNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCTAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 110 ILILTVMAYDRYVAICKPLHYSIIMSRGRchamvtaccAGAFIHSFLQSLLAISL-PFCGHNE---MDHYFCDIyplltl 185
Cdd:cd15327   88 ILSLCVISVDRYVGVKHSLKYPTIMTERK---------AGVILVLLWVSSMVISIgPLLGWKEpppPDESICSI------ 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 186 sctnTHRVGLLVVANSGMMGLVTFVVLMwsYYFILYTIrAYPAESRSKALSTCSSHVTVVIFFFVPvlFIYIRPATTY-- 263
Cdd:cd15327  153 ----TEEPGYALFSSLFSFYLPLMVILV--MYFRVYVV-ALKFSREKKAAKTLAIVVGVFILCWFP--FFFVLPLGSFfp 223

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110735416 264 ---PEDKVFALFYTI--LAPMFNPLIYTLRNTEMKNAL 296
Cdd:cd15327  224 alkPSEMVFKVIFWLgyFNSCVNPIIYPCSSKEFKRAF 261

7tmA_GHSR-like

cd15928

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...

21-152

4.77e-03

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.

Pssm-ID: 320594 [Multi-domain] Cd Length: 288 Bit Score: 37.85 E-value: 4.77e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  21 IKALCFLMFLFCyiaiLGGNMIILISITCSQLIEQPMYFFLNYLALSDLcYTSTVTPKFLTDLLVERN-KISYTSCMAQL 99
Cdd:cd15928    3 VTAVCSVLMLVG----ASGNLLTVLVIGRSRDMRTTTNLYLSSLAVSDL-LIFLVLPLDLYRLWRYRPwRFGDLLCRLMY 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 110735416 100 FTMHFFGGIEILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTACCAGAFI 152
Cdd:cd15928   78 FFSETCTYASILHITALSVERYLAICHPLRAKVLVTRGRVKLLIAVIWAVAIV 130

7tmA_photoreceptors_insect

cd15079

insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...

24-146

4.78e-03

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320207 [Multi-domain] Cd Length: 292 Bit Score: 37.94 E-value: 4.78e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  24 LCFLMFLFCYIAILGGNMIILISITCSQLIEQPMYFFLNyLALSDLCYTSTvTPKFLTDLLVERNKISYTSCMAQLFTMH 103
Cdd:cd15079    3 LGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVN-LAISDFLMMIK-MPIFIYNSFYEGWALGPLGCQIYAFLGS 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 110735416 104 FFGGIEILILTVMAYDRYVAICKPLHYSiIMSRGRCHAMVTAC 146
Cdd:cd15079   81 LSGIGSIWTNAAIAYDRYNVIVKPLNGN-PLTRGKALLLILFI 122

7tmA_Adenosine_R_A3

cd15070

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...

39-296

5.61e-03

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.

Pssm-ID: 320198 [Multi-domain] Cd Length: 280 Bit Score: 37.84 E-value: 5.61e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPkfLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAY 118
Cdd:cd15070   17 GNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVGVLVIP--LAIVVSLGVTIHFYSCLFMSCLLVVFTHASIMSLLAIAV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 119 DRYVAICKPLHYSIIMSRGRCHAMVTACcagafihsFLQSLLAISLPFCGHNEMDHYFCDIYPLLTLSCTNTHRVGLLVV 198
Cdd:cd15070   95 DRYLRVKLTVRYRIVTTQRRIWLALGLC--------WLVSFLVGLTPMFGWNRKPSLESVNTTPLQCQFTSVMRMDYMVY 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 199 ANSGMMGLVTFVVLMWSYYFILYTIRAYPAESRS----------KALSTCSSHVTVVIFFFVPVLFIYIRPATTYPEDKV 268
Cdd:cd15070  167 FSFFTWILIPLVIMCALYVDIFYIIRNKLSQNATgfretgafygREFKTAKSLALVLFLFAVCWLPLSIINCVVYFNPKV 246

                        250       260       270
                 ....*....|....*....|....*....|....
gi 110735416 269 --FALFYTILA----PMFNPLIYTLRNTEMKNAL 296
Cdd:cd15070  247 pkIALYLGILLshanSMMNPIVYACKIKKFKETY 280

7tmA_5-HT1_5_7

cd15064

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...

39-295

6.04e-03

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.

Pssm-ID: 320192 [Multi-domain] Cd Length: 258 Bit Score: 37.69 E-value: 6.04e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAY 118
Cdd:cd15064   17 GNALVIAAILLTRKLHTPANYLIASLAVADLLVAVLVMPLSAVYELTGRWILGQVLCDIWISLDVTCCTASILHLCVIAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 119 DRYVAICKPLHYSiiMSRGRCHAMVTACCAGAFIhsflqslLAISLP----FCGHNEMDHYFCDIyplltlsctnTHRVG 194
Cdd:cd15064   97 DRYWAITDAVEYA--HKRTPKRAAVMIALVWTLS-------ICISLPplfgWRTPDSEDPSECLI----------SQDIG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 195 LLVVANSGMMGLVTFVVLmwsyyfILYTiRAYPAESRS-KALSTCSSHVTVVIF----FFVPVLFIYIRPATTYPED-KV 268
Cdd:cd15064  158 YTIFSTFGAFYIPLLLML------ILYW-KIYRAAARErKAAKTLGIILGAFIVcwlpFFLVALIVPLCSHCWIPLAlKS 230

                        250       260
                 ....*....|....*....|....*..
gi 110735416 269 FALFYTILAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15064  231 FFLWLGYFNSLINPLIYTFFNKDFRKA 257

7tmA_NPR-like_invertebrate

cd15391

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...

37-139

6.20e-03

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.

Pssm-ID: 320513 [Multi-domain] Cd Length: 289 Bit Score: 37.49 E-value: 6.20e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  37 LGGNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVM 116
Cdd:cd15391   15 VGGNYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMALFCMPFTFTQIMLGHWVFPAPMCPIVLYVQLVSVTASVLTNTAI 94

                         90       100
                 ....*....|....*....|...
gi 110735416 117 AYDRYVAICKPLHYSIIMSRGRC 139
Cdd:cd15391   95 GIDRFFAVIFPLRSRHTKSRTKC 117

7tmA_GnRHR-like

cd15195

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...

39-160

6.33e-03

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.

Pssm-ID: 320323 [Multi-domain] Cd Length: 293 Bit Score: 37.76 E-value: 6.33e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  39 GNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPKFLTDLLVERNKISYTSCMAQLFTMHFFGGIEILILTVMAY 118
Cdd:cd15195   17 GNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFFNMPMDAVWNYTVEWLAGDLMCRVMMFLKQFGMYLSSFMLVVIAL 96

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 110735416 119 DRYVAICKPLhySIIMSRGRCHAMVTACCAGAFIHSFLQSLL 160
Cdd:cd15195   97 DRVFAILSPL--SANQARKRVKIMLTVAWVLSALCSIPQSFI 136

7tmA_VA_opsin

cd15082

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...

22-128

6.88e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.

Pssm-ID: 320210 [Multi-domain] Cd Length: 291 Bit Score: 37.47 E-value: 6.88e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  22 KALCFLMFLFCYIAILGGNMIILISITCSQLiEQPMYFFLNYLALSDLCYTSTV-TPKFLTDLLvERNKISYTSCMAQLF 100
Cdd:cd15082   14 TVLAALMFVVTSLSLAENFAVMLVTFRFKQL-RQPLNYIIVNLSVADFLVSLTGgTISFLTNAR-GYFFLGVWACVLEGF 91

                         90       100
                 ....*....|....*....|....*...
gi 110735416 101 TMHFFGGIEILILTVMAYDRYVAICKPL 128
Cdd:cd15082   92 AVTFFGIVALWSLAVLAFERFFVICRPL 119

7tmA_Dop1R2-like

cd15067

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...

23-295

8.54e-03

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.

Pssm-ID: 320195 [Multi-domain] Cd Length: 262 Bit Score: 36.95 E-value: 8.54e-03

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416  23 ALCFLMFLFCYIAILGgNMIILISITCSQLIEQPMYFFLNYLALSDLCYTSTVTPkFLTDLLVERNKISYTSCMAQLFtm 102
Cdd:cd15067    1 LLGVVLSLFCLVTVAG-NLLVILAVLRERYLRTVTNYFIVSLAVADLLVGSIVMP-FSILHEMTGGYWLFGRDWCDVW-- 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 103 HFFGGI----EILILTVMAYDRYVAICKPLHYSIIMSRGRCHAMVTAccagAFIHSFLQSLLAI-----SLPfcghnemd 173
Cdd:cd15067   77 HSFDVLastaSILNLCVISLDRYWAITDPISYPSRMTKRRALIMIAL----VWICSALISFPAIawwraVDP-------- 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110735416 174 hyfcdiYPLLTLSCTNTHRVGLLVVANsgmmgLVTF----VVLMWSYYfilytiRAYPAESRS-KALSTCSSHVTVVIF- 247
Cdd:cd15067  145 ------GPSPPNQCLFTDDSGYLIFSS-----CVSFyiplVVMLFTYY------RIYRAAAKEqKAAKTLGIVMGVFILc 207

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 110735416 248 ---FFVPVLFIYIRPATTYP-EDKVFALFYTI--LAPMFNPLIYTLRNTEMKNA 295
Cdd:cd15067  208 wlpFFVTNILIGFCPSNCVSnPDILFPLVTWLgyINSGMNPIIYACSSRDFRRA 261

Blast search parameters

Data Source:	Precalculated data, version = cdd.v.3.21
Preset Options:	Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01