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Conserved domains on  [gi|110578653|ref|NP_612203|]
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zinc finger protein 675 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.66e-30

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 2.66e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 110578653     4 LTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-556 1.05e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 169 NKPFKCKECGRSFCMLSHLTRHER--NYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNltEY 246
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRshTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 247 KKDYAREKPYKCE-ECGKAFNQSSHLTTHKIIHTGEKPYKCEE-------------------------CGKAFNQFSNLT 300
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 301 THKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTgEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRS 380
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 381 SNLTEHRKIHTEE-------KPYKCKECGKAFKHSSALTTHKR--IHTGE--KPYKCEE--CGKAFNRSSKLTEHKKLHT 447
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 448 GKKPYKC--EECGKAFIQSS-----KLTEHKKIHSGEIPYKCE--ECGKAFKHSSSLTTHKRIHTGEKP--YKCEECGKA 516
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 110578653 517 FSRSSKLTEHKIIHTGEKPYKCeRCDKAFNQSANLTKHKK 556
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.66e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 2.66e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 110578653     4 LTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.79e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.79e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 110578653    3 LLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.94e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 110578653   4 LTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-556 1.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 169 NKPFKCKECGRSFCMLSHLTRHER--NYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNltEY 246
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRshTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 247 KKDYAREKPYKCE-ECGKAFNQSSHLTTHKIIHTGEKPYKCEE-------------------------CGKAFNQFSNLT 300
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 301 THKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTgEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRS 380
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 381 SNLTEHRKIHTEE-------KPYKCKECGKAFKHSSALTTHKR--IHTGE--KPYKCEE--CGKAFNRSSKLTEHKKLHT 447
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 448 GKKPYKC--EECGKAFIQSS-----KLTEHKKIHSGEIPYKCE--ECGKAFKHSSSLTTHKRIHTGEKP--YKCEECGKA 516
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 110578653 517 FSRSSKLTEHKIIHTGEKPYKCeRCDKAFNQSANLTKHKK 556
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-435 3.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 110578653  410 ALTTHKRIHTGEKPYKCEECGKAFNR 435
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
4-62 2.66e-30

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 112.69  E-value: 2.66e-30
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 110578653     4 LTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLGIAVSKQDLITCLEQEKEP 62
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 1.79e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 87.14  E-value: 1.79e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 110578653    3 LLTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFLG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-43 1.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 78.75  E-value: 1.94e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 110578653   4 LTFRDVAIEFSLEEWQCLDTAQRNLYKNVILENYRNLVFL 43
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
169-556 1.05e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.95  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 169 NKPFKCKECGRSFCMLSHLTRHER--NYTKVNFCKCEECEKAVNQSSKLTKHKRIYTCEKLYKCQECDRTFNQFSNltEY 246
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRshTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKAS--SS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 247 KKDYAREKPYKCE-ECGKAFNQSSHLTTHKIIHTGEKPYKCEE-------------------------CGKAFNQFSNLT 300
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 301 THKKIHTGEQPYICEECGKAFTQSSTLTTHKRIHTgEKPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKCEECGKAFNRS 380
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPT 267

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 381 SNLTEHRKIHTEE-------KPYKCKECGKAFKHSSALTTHKR--IHTGE--KPYKCEE--CGKAFNRSSKLTEHKKLHT 447
Cdd:COG5048  268 ASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHT 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 448 GKKPYKC--EECGKAFIQSS-----KLTEHKKIHSGEIPYKCE--ECGKAFKHSSSLTTHKRIHTGEKP--YKCEECGKA 516
Cdd:COG5048  348 SISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKS 427

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 110578653 517 FSRSSKLTEHKIIHTGEKPYKCeRCDKAFNQSANLTKHKK 556
Cdd:COG5048  428 FNRHYNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
254-558 1.34e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.34e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 254 KPYKCEECGKAFNQSSHLTTHKIIHTGEKPYKC--EECGKAFNQFSNLTTHKKIHTGEQPYicEECGKAFTQSSTLTTHK 331
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 332 RIHTGEKPYKCE-ECGKAFNRSSKLTEHKNIHTGEQPYKCEE-------------------------CGKAFNRSSNLTE 385
Cdd:COG5048  110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 386 HRKIHTEEKPYKCKECGKAFKHSSALTTHKRIHTgEKPYKCEECGKAF----NRSSKLTEHKKLHTGKKPYKCEECGKaf 461
Cdd:COG5048  190 SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSSLP-- 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 462 IQSSKLTEHKKIHSGEI-----PYKCEECGKAFKHSSSLTTHKR--IHTGE--KPYKCEE--CGKAFSRSSKLTEHKIIH 530
Cdd:COG5048  267 TASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                        330       340       350
                 ....*....|....*....|....*....|
gi 110578653 531 TGEKPYKC--ERCDKAFNQSANLTKHKKIH 558
Cdd:COG5048  347 TSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
322-395 1.36e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 322 TQSSTLTTHKRIHTGE----KPYKCEECGKAFNRSSKLTEHKNIHTGEQPYKC--EECGKAFNRSSNLTEHRKIHTEEKP 395
Cdd:COG5048   12 NNSVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPS 91
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 336-415 2.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 336 GEKPYKCE--ECGKAFNRSSKLTEHKnihtgeqpyKCEECGKAFNRSSNLTEHRKIHTEEKPYKCKECGKAFKHSSALTT 413
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 110578653 414 HK 415
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
410-435 3.51e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.51e-04
                          10        20
                  ....*....|....*....|....*.
gi 110578653  410 ALTTHKRIHTGEKPYKCEECGKAFNR 435
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
494-519 4.15e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.15e-04
                          10        20
                  ....*....|....*....|....*.
gi 110578653  494 SLTTHKRIHTGEKPYKCEECGKAFSR 519
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
327-351 4.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.85e-04
                          10        20
                  ....*....|....*....|....*
gi 110578653  327 LTTHKRIHTGEKPYKCEECGKAFNR 351
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 476-556 5.26e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 476 GEIPYKCE--ECGKAFKHSSSLTTHKrihtgekpyKCEECGKAFSRSSKLTEHKIIHTGEKPYKCERCDKAFNQSANLTK 553
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 110578653 554 HKK 556
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 392-475 7.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 7.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 392 EEKPYKCKECGKAFKHSSALTTH---KRIHT-GEKPYKCE--ECGKAFNRSSKLTEHKK-------------------LH 446
Cdd:COG5189  314 RKLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFS 393

                         90       100
                 ....*....|....*....|....*....
gi 110578653 447 TGKKPYKCEECGKAFIQSSKLTEHKKiHS 475
Cdd:COG5189  394 AKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-407 7.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 110578653  382 NLTEHRKIHTEEKPYKCKECGKAFKH 407
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
270-295 9.46e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.46e-04
                          10        20
                  ....*....|....*....|....*.
gi 110578653  270 HLTTHKIIHTGEKPYKCEECGKAFNQ 295
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 364-444 1.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.34e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 364 GEQPYKCE--ECGKAFNRSSNLTEHRKiHteekpykcKECGKAFKHSSALTTHKRIHTGEKPYKCEECGKAFNRSSKLTE 441
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ...
gi 110578653 442 HKK 444
Cdd:COG5189  417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 280-359 2.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 2.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110578653 280 GEKPYKCE--ECGKAFNQFSNLTTHKKiHTgeqpyiceECGKAFTQSSTLTTHKRIHTGEKPYKCEECGKAFNRSSKLTE 357
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 110578653 358 HK 359
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
439-463 3.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.89e-03
                          10        20
                  ....*....|....*....|....*
gi 110578653  439 LTEHKKLHTGKKPYKCEECGKAFIQ 463
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 253-304 4.05e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 4.05e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110578653 253 EKPYKCE--ECGKAFNQSSHLTTHK-------------------IIHTGEKPYKCEECGKAFNQFSNLTTHKK 304
Cdd:COG5189  347 GKPYKCPveGCNKKYKNQNGLKYHMlhghqnqklhenpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
523-547 6.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.30e-03
                          10        20
                  ....*....|....*....|....*
gi 110578653  523 LTEHKIIHTGEKPYKCERCDKAFNQ 547
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
467-491 9.06e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.06e-03
                          10        20
                  ....*....|....*....|....*
gi 110578653  467 LTEHKKIHSGEIPYKCEECGKAFKH 491
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 368-390 9.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.56e-03
                          10        20
                  ....*....|....*....|...
gi 110578653  368 YKCEECGKAFNRSSNLTEHRKIH 390
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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