NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|110341893|gb|ABG68130|]
View 

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Escherichia coli 536]

Protein Classification

Mur ligase family protein( domain architecture ID 11433699)

Mur ligase family protein similar to UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase (MurD) and UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase (MurD2), which catalyze the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)

CATH:  3.40.1190.10|3.90.190.20|3.40.50.720
EC:  6.3.2.-
Gene Ontology:  GO:0008764|GO:0005524

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


:

Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 564.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   3 DYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLD-KLPEA-VERHTGGLNDEWLMAADLIVASPGIALAHP 80
Cdd:COG0771    1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  81 SLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDEC--ELYVLE 158
Cdd:COG0771   81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 159 LSSFQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALTMPI-RGADERCVSFGVN 234
Cdd:COG0771  161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRALaEEAKARVVPFSLK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 235 M---GDYHLnhQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 311
Cdd:COG0771  240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 312 GVRWVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVA---EQT 388
Cdd:COG0771  318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 110341893 389 ETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
Cdd:COG0771  396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 564.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   3 DYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLD-KLPEA-VERHTGGLNDEWLMAADLIVASPGIALAHP 80
Cdd:COG0771    1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  81 SLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDEC--ELYVLE 158
Cdd:COG0771   81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 159 LSSFQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALTMPI-RGADERCVSFGVN 234
Cdd:COG0771  161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRALaEEAKARVVPFSLK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 235 M---GDYHLnhQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 311
Cdd:COG0771  240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 312 GVRWVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVA---EQT 388
Cdd:COG0771  318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 110341893 389 ETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
Cdd:COG0771  396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-435 2.14e-151

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 436.39  E-value: 2.14e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893    8 NVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTP-----PGLDKLPEAVERHTGgLNDEWLMAADLIVASPGIALAHPSL 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEelepsMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   83 SAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE-CELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDQEgAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  162 FQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENA---KVCVVNADD-ALTMPIRGADERCVSFGVNmgd 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHG-SFEDYVAAKLKIFARQtegDVAVLNADDpRFARLAQKSKAQVIWFSVE--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  238 yhlnhQQGETWLRVKGEKVL---NVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVR 314
Cdd:TIGR01087 236 -----KDAERGLCIRDGGLYlkpNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVH 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  315 WVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQT---ETM 391
Cdd:TIGR01087 311 FYNDSKATNVHATLAALSAF--DNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVylvESL 388

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 110341893  392 EQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAK 435
Cdd:TIGR01087 389 EEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 3-437 2.69e-102

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 311.91  E-value: 2.69e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   3 DYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPP---GLDKLPEA-VERHTGGLNDEWLMAADLIVASPGIALA 78
Cdd:PRK14106   2 ELKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGELgIELVLGEYPEEFLEGVDLVVVSPGVPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  79 HPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPalmlLDDECELY--- 155
Cdd:PRK14106  82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYP----LIDAVEEYged 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 156 ---VLELSSFQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALTMP-IRGADERC 228
Cdd:PRK14106 158 diiVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHK-TMENYIKAKARIFENQRpsdYTVLNYDDPRTRSlAKKAKARV 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 229 VSF--------GVNMgdyhlnhQQGETWLRVKG--EKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFT 298
Cdd:PRK14106 237 IFFsrkslleeGVFV-------KNGKIVISLGGkeEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 299 GLPHRFEVVLEHNGVRWVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLA 378
Cdd:PRK14106 310 GVEHRIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIA 387

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110341893 379 -ALRP---EVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
Cdd:PRK14106 388 eAARKygfDNILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-272 5.66e-23

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 95.83  E-value: 5.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  110 ITGSNGKSTVTTLVGEMAKAAGVNVGVGGN------------IGLPALM--LLDDECELYVLELSSFQLE---TTSSLQA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTLaeMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  173 VAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAKVC---VVNADDALTMPIR----GADERCVSFGVN------MGDYH 239
Cdd:pfam08245  81 DIAVFTNISPDHLDFHG-TMENYAKAKAELFEGLPEDgiaVINADDPYGAFLIaklkKAGVRVITYGIEgeadlrAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 110341893  240 LNHQQGETWLRVKGEKVLNVkEMKLSGQHNYTN 272
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEI-EIPLLGRHNVYN 191
 
Name Accession Description Interval E-value
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-437 0e+00

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 564.71  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   3 DYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPPGLD-KLPEA-VERHTGGLNDEWLMAADLIVASPGIALAHP 80
Cdd:COG0771    1 DLKGKKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPAPELAAaELEAPgVEVVLGEHPEELLDGADLVVKSPGIPPDHP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  81 SLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDEC--ELYVLE 158
Cdd:COG0771   81 LLKAARAAGIPVIGEIELAYRLSPAPIIAITGTNGKTTTTTLIGHILKAAGLRVAVGGNIGTPLLDLLLEPEppDVYVLE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 159 LSSFQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALTMPI-RGADERCVSFGVN 234
Cdd:COG0771  161 LSSFQLETTPSLRPDVAVILNITPDHLDRHG-SMEAYAAAKARIFANQTpddYAVLNADDPLTRALaEEAKARVVPFSLK 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 235 M---GDYHLnhQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHN 311
Cdd:COG0771  240 EpleGGAGL--EDGKLVDRASGEELLPVDDLRLPGRHNLENALAALAAARALGVPPEAIREALRSFKGLPHRLEFVAEIN 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 312 GVRWVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVA---EQT 388
Cdd:COG0771  318 GVRFINDSKATNPDATLAALESF--DGPVVLIAGGLDKGADFSPLAPAVAERVKAVVLIGEDAEKIAAALAGAGvpvVIV 395

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*....
gi 110341893 389 ETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
Cdd:COG0771  396 ETMEEAVAAAAELARPGDVVLLSPACASFDQFKNYEERGDVFKEAVREL 444
murD TIGR01087
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ...
 8-435 2.14e-151

UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273436 [Multi-domain]  Cd Length: 433  Bit Score: 436.39  E-value: 2.14e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893    8 NVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTP-----PGLDKLPEAVERHTGgLNDEWLMAADLIVASPGIALAHPSL 82
Cdd:TIGR01087   1 KILILGLGKTGRAVARFLHKKGAEVTVTDLKPNEelepsMGQLRLNEGSVLHTG-LHLEDLNNADLVVKSPGIPPDHPLV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   83 SAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPALMLLDDE-CELYVLELSS 161
Cdd:TIGR01087  80 QAAAKRGIPVVGDIELFLRLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLKAFLGGNIGTPALEVLDQEgAELYVLELSS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  162 FQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENA---KVCVVNADD-ALTMPIRGADERCVSFGVNmgd 237
Cdd:TIGR01087 160 FQLETTESLRPEIALILNISEDHLDWHG-SFEDYVAAKLKIFARQtegDVAVLNADDpRFARLAQKSKAQVIWFSVE--- 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  238 yhlnhQQGETWLRVKGEKVL---NVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVR 314
Cdd:TIGR01087 236 -----KDAERGLCIRDGGLYlkpNDLEGSLLGLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNGVH 310

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  315 WVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLAALRPEVAEQT---ETM 391
Cdd:TIGR01087 311 FYNDSKATNVHATLAALSAF--DNPVILIVGGDDKGADFSPLAPAAAGKVKAVLAIGEDAAKIAPLLKEAGLSVylvESL 388

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....
gi 110341893  392 EQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAK 435
Cdd:TIGR01087 389 EEAVQAAREVASPGDVVLLSPACASFDQFKSYEERGEKFKELVR 432
murD PRK14106
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
 3-437 2.69e-102

UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional


Pssm-ID: 184511 [Multi-domain]  Cd Length: 450  Bit Score: 311.91  E-value: 2.69e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   3 DYQGKNVVIIGLGLTGLSCVDFFLARGVTPRVMDTRMTPP---GLDKLPEA-VERHTGGLNDEWLMAADLIVASPGIALA 78
Cdd:PRK14106   2 ELKGKKVLVVGAGVSGLALAKFLKKLGAKVILTDEKEEDQlkeALEELGELgIELVLGEYPEEFLEGVDLVVVSPGVPLD 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  79 HPSLSAAADAGIEIVGDIELFCREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGLPalmlLDDECELY--- 155
Cdd:PRK14106  82 SPPVVQAHKKGIEVIGEVELAYRFSKAPIVAITGTNGKTTTTTLLGEIFKNAGRKTLVAGNIGYP----LIDAVEEYged 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 156 ---VLELSSFQLETTSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALTMP-IRGADERC 228
Cdd:PRK14106 158 diiVAEVSSFQLETIKEFKPKVGCILNITPDHLDRHK-TMENYIKAKARIFENQRpsdYTVLNYDDPRTRSlAKKAKARV 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 229 VSF--------GVNMgdyhlnhQQGETWLRVKG--EKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFT 298
Cdd:PRK14106 237 IFFsrkslleeGVFV-------KNGKIVISLGGkeEEVIDIDEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFK 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 299 GLPHRFEVVLEHNGVRWVNDSKATNVGSTEAALNGLhvDGTLHLLLGGDGKSADFSPLARYLNGDNVRLYCFGRDGAQLA 378
Cdd:PRK14106 310 GVEHRIEFVAEINGVKFINDSKGTNPDAAIKALEAY--ETPIVLIAGGYDKGSDFDEFAKAFKEKVKKLILLGETAQEIA 387

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110341893 379 -ALRP---EVAEQTETMEQAMRLLAPRVQPGDMVLLSPACASLDQFKNFEQRGNEFARLAKEL 437
Cdd:PRK14106 388 eAARKygfDNILFAETLEEAVKKAYEIAKPGDVVLLSPACASWDMFKNFEERGRLFKELVLEL 450
Mur_ligase_M pfam08245
Mur ligase middle domain;
110-272 5.66e-23

Mur ligase middle domain;


Pssm-ID: 462409 [Multi-domain]  Cd Length: 199  Bit Score: 95.83  E-value: 5.66e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  110 ITGSNGKSTVTTLVGEMAKAAGVNVGVGGN------------IGLPALM--LLDDECELYVLELSSFQLE---TTSSLQA 172
Cdd:pfam08245   1 VTGTNGKTTTTELIAAILSLAGGVIGTIGTyigksgnttnnaIGLPLTLaeMVEAGAEYAVLEVSSHGLGegrLSGLLKP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  173 VAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAKVC---VVNADDALTMPIR----GADERCVSFGVN------MGDYH 239
Cdd:pfam08245  81 DIAVFTNISPDHLDFHG-TMENYAKAKAELFEGLPEDgiaVINADDPYGAFLIaklkKAGVRVITYGIEgeadlrAANIE 159

                         170       180       190
                  ....*....|....*....|....*....|...
gi 110341893  240 LNHQQGETWLRVKGEKVLNVkEMKLSGQHNYTN 272
Cdd:pfam08245 160 LSSDGTSFDLFTVPGGELEI-EIPLLGRHNVYN 191
MurF COG0770
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 101-437 2.36e-20

UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440533 [Multi-domain]  Cd Length: 451  Bit Score: 92.86  E-value: 2.36e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 101 REAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGN----IGLPaLMLL--DDECELYVLEL--SSF-QLETTSSL- 170
Cdd:COG0770   96 ARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNfnneIGVP-LTLLrlPEDHEFAVLEMgmNHPgEIAYLARIa 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 171 QAVAATILNVTEDHMDRypFG-LQQYRAAKLRIYENAK---VCVVNADDALTMPIRG-ADERCVSFGVNMG------DYH 239
Cdd:COG0770  175 RPDIAVITNIGPAHLEG--FGsLEGIARAKGEIFEGLPpggVAVLNADDPLLAALAErAKARVLTFGLSEDadvraeDIE 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 240 LNHQQGETWLRVKGEKVlNVKeMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWVNDS 319
Cdd:COG0770  253 LDEDGTRFTLHTPGGEL-EVT-LPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEGAGGVTLIDDS 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 320 -KAtNVGSTEAA---LNGLHVDGTLHLLLGGDGKSADFSP-----LARYLNGDNV-RLYCFGRDGAQLA-ALRPEVAEQT 388
Cdd:COG0770  331 yNA-NPDSMKAAldvLAQLPGGGRRIAVLGDMLELGEESEelhreVGELAAELGIdRLFTVGELARAIAeAAGGERAEHF 409

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 110341893 389 ETMEQAMRLLAPRVQPGDMVLLspaCASldqfknfeqRGNEFARLAKEL 437
Cdd:COG0770  410 EDKEELLAALKALLRPGDVVLV---KGS---------RGMGLERVVEAL 446
murF TIGR01143
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ...
 100-410 4.33e-19

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273468 [Multi-domain]  Cd Length: 417  Bit Score: 88.86  E-value: 4.33e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  100 CREAQAPIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGN----IGLP-ALMLLDDECELYVLELS-SFQLE---TTSSL 170
Cdd:TIGR01143  69 RAKFSGKVIGITGSSGKTTTKEMLAAILSHKYKVFATPGNfnneIGLPlTLLRAPGDHDYAVLEMGaSHPGEiayLAEIA 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  171 QAVAATILNVTEDHMDRypFGLQQYRA-AKLRIYENAKVC---VVNADDALTMPIRG--ADERCVSFGVNMGDYHLN--- 241
Cdd:TIGR01143 149 KPDIAVITNIGPAHLEG--FGSLEGIAeAKGEILQGLKENgiaVINADDPAFADLAKrlPNRNILSFGFEGGDFVAKdis 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  242 -HQQGETWLRVKGEKVLNVKEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEvVLEHNGVRWVNDSK 320
Cdd:TIGR01143 227 ySALGSTSFTLVAPGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRFE-VQTKNGLTLIDDTY 305

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  321 ATNVGSTEAALNGL-HVDGTLHLLLGGDGKSADFSP-----LARYLNGDNVRLYCF-GRDGAQLAALRPEVAEQTETMEQ 393
Cdd:TIGR01143 306 NANPDSMRAALDALaRFPGKKILVLGDMAELGEYSEelhaeVGRYANSLGIDLVFLvGEEAAVIYDSFGKQGKHFADKDE 385

                         330
                  ....*....|....*..
gi 110341893  394 AMRLLAPRVQPGDMVLL 410
Cdd:TIGR01143 386 LLAFLKTLVRKGDVVLV 402
murC TIGR01082
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ...
 66-318 1.71e-18

UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273433 [Multi-domain]  Cd Length: 448  Bit Score: 87.36  E-value: 1.71e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893   66 ADLIVASPGIALAHPSLSAAADAGIEIV--GDI--ELFCREaqaPIVAITGSNGKSTVTTLVGEMAKAAGVN--VGVGGN 139
Cdd:TIGR01082  59 ADVVVVSAAIKDDNPEIVEAKERGIPVIrrAEMlaELMRFR---HSIAVAGTHGKTTTTAMIAVILKEAGLDptVVVGGL 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  140 IGLpalmlLDDEC-----ELYVLEL----SSFqlettSSLQAVAATILNVTEDHMDRYPFGLQQYRAAKLRIYENAK--- 207
Cdd:TIGR01082 136 VKE-----AGTNArlgsgEYLVAEAdesdASF-----LHLQPNVAIVTNIEPDHLDTYGSSFERLKAAFEKFIHNLPfyg 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  208 VCVVNADDALTMPI-RGADERCVSFGVNMGDYHL---NHQQ----GETWLRVKGEKVLNVKeMKLSGQHNYTNALAALAL 279
Cdd:TIGR01082 206 LAVICADDPVLRELvPKATEQVITYGGSGEDADYraeNIQQsgaeGKFSVRGKGKLYLEFT-LNLPGRHNVLNALAAIAV 284

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 110341893  280 ADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVRWVND 318
Cdd:TIGR01082 285 ALELGIDFEAILRALANFQGVKRRFEILGEFGGVLLIDD 323
MurE COG0769
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ...
 107-348 1.78e-15

UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440532 [Multi-domain]  Cd Length: 459  Bit Score: 78.20  E-value: 1.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIG-------------------LPALM--LLDDECELYVLELSSFQLE 165
Cdd:COG0769   82 LIGVTGTNGKTTTTYLLAQILRALGKKTGLIGTVGngiggelipsslttpealdLQRLLaeMVDAGVTHVVMEVSSHALD 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 166 T--TSSLQAVAATILNVTEDHMDrYPFGLQQYRAAKLRIYEN---AKVCVVNADDALTMPI-RGADERCVSFGV-NMGDY 238
Cdd:COG0769  162 QgrVDGVRFDVAVFTNLTRDHLD-YHGTMEAYFAAKARLFDQlgpGGAAVINADDPYGRRLaAAAPARVITYGLkADADL 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 239 H---LNHQQGETWLRVK---GEKVLNVKemkLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNG 312
Cdd:COG0769  241 RatdIELSADGTRFTLVtpgGEVEVRLP---LIGRFNVYNALAAIAAALALGIDLEEILAALEKLKGVPGRMERVDGGQG 317

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 110341893 313 VRWVNDSkATNVGSTEAALNGL--HVDGTLHLLLGGDG 348
Cdd:COG0769  318 PTVIVDY-AHTPDALENVLEALrpHTKGRLIVVFGCGG 354
MurC COG0773
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ...
 61-314 1.92e-14

UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440536 [Multi-domain]  Cd Length: 451  Bit Score: 74.72  E-value: 1.92e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  61 EWLMAADLIVASPGIALAHPSLSAAADAGIEIV------GDIelfCREAQApiVAITGSNGKSTVTTLVGEMAKAAGVNV 134
Cdd:COG0773   59 ENIDDADLVVVSSAIPRDNPELVAARERGIPVLsraemlAEL---MRGKRS--IAVAGTHGKTTTTSMLAHILEEAGLDP 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 135 G--VGG---NIGLPALMlldDECELYVLE----LSSFQLettssLQAVAATILNVTEDHMDRYPfGLQQYRAA--KL--R 201
Cdd:COG0773  134 TflIGGilnNFGTNARL---GDGDYFVAEadesDGSFLH-----YSPDIAVVTNIEADHLDIYG-DLEAIKEAfhEFarN 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 202 IYENAKVcVVNADDALTMPI-RGADERCVSFGVNM-GDYHL-NHQQGETW----LRVKGEKVLNVkEMKLSGQHNYTNAL 274
Cdd:COG0773  205 VPFYGLL-VLCADDPGLRELlPRCGRPVITYGFSEdADYRAeNIRIDGGGstfdVLRRGEELGEV-ELNLPGRHNVLNAL 282

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 110341893 275 AALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNGVR 314
Cdd:COG0773  283 AAIAVALELGVDPEAIAEALASFKGVKRRFELKGEVGGVT 322
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 107-307 1.85e-10

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 63.18  E-value: 1.85e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIG-------------------LPALM--LLDDECELYVLELSSFQLE 165
Cdd:PRK11929 114 LVAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGarldgrlipgslttpdaiiLHRILarMRAAGADAVAMEASSHGLE 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 166 TT--SSLQAVAATILNVTEDHMDrYPFGLQQYRAAKLRIYENAK---VCVVNADDA----LTMPIRGADERCVSFGVNMG 236
Cdd:PRK11929 194 QGrlDGLRIAVAGFTNLTRDHLD-YHGTMQDYEEAKAALFSKLPglgAAVINADDPaaarLLAALPRGLKVGYSPQNAGA 272

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 110341893 237 DYHLNH-QQGETWLRVK---GEKVLNVKeMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVV 307
Cdd:PRK11929 273 DVQARDlRATAHGQVFTlatPDGSYQLV-TRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMERV 346
murE TIGR01085
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ...
 107-307 4.14e-10

UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]


Pssm-ID: 273435 [Multi-domain]  Cd Length: 464  Bit Score: 61.56  E-value: 4.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  107 IVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL----------------PALMLL--------DDECELYVLELSSF 162
Cdd:TIGR01085  87 VIGVTGTNGKTTTTSLIAQLLRLLGKKTGLIGTIGYrlggndliknpaalttPEALTLqstlaemvEAGAQYAVMEVSSH 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  163 QLEtTSSLQAV---AATILNVTEDHMDrYPFGLQQYRAAKLRIYEN---AKVCVVNADDALTMPIRG--ADERCVSFGVN 234
Cdd:TIGR01085 167 ALA-QGRVRGVrfdAAVFTNLSRDHLD-FHGTMENYFAAKASLFTElglKRFAVINLDDEYGAQFVKrlPKDITVSAITQ 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  235 MGDY-HLNHQQGETWLRVKGEKvLNVK--------EMKLSGQHNYTNALAA-LALADAAGLPRASSLKALTTFTGLPHRF 304
Cdd:TIGR01085 245 PADGrAQDIKITDSGYSFEGQQ-FTFEtpageghlHTPLIGRFNVYNLLAAlATLLHLGGIDLEDIVAALEKFRGVPGRM 323


                  ...
gi 110341893  305 EVV 307
Cdd:TIGR01085 324 ELV 326
PRK11929 PRK11929
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ...
 101-409 5.81e-10

bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;


Pssm-ID: 237025 [Multi-domain]  Cd Length: 958  Bit Score: 61.64  E-value: 5.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 101 REAQA-PIVAITGSNGKSTVTTLVGEMAKAAGVNVGV---GGN----IGLP-ALMLLDDECELYVLEL---SSFQLETTS 168
Cdd:PRK11929 598 RARFSlPVVAITGSNGKTTTKEMIAAILAAWQGEDRVlatEGNfnneIGVPlTLLRLRAQHRAAVFELgmnHPGEIAYLA 677

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 169 SL-QAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENAK---VCVVNADDALT-MPIRGADERCV-SFGVNMG------ 236
Cdd:PRK11929 678 AIaAPTVALVTNAQREHQEFMH-SVEAVARAKGEIIAALPedgVAVVNGDDPYTaIWAKLAGARRVlRFGLQPGadvyae 756

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 237 ----DYHLNHQQGETWLRVKGEKVLNVkEMKLSGQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNG 312
Cdd:PRK11929 757 kiakDISVGEAGGTRCQVVTPAGSAEV-YLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCG 835

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 313 VRWVNDSKATNVGSTEAALNGL-HVDGTLHLLLGGD-GKSADFSPLA-----RYLNGDNVR-LYCFGRDGAQLAALRPEV 384
Cdd:PRK11929 836 TRIIDDTYNANPDSMRAAIDVLaELPNGPRALVLGDmLELGDNGPAMhrevgKYARQLGIDaLITLGEAARDAAAAFGAG 915

                        330       340
                 ....*....|....*....|....*.
gi 110341893 385 AE-QTETMEQAMRLLAPRVQPGDMVL 409
Cdd:PRK11929 916 ARgVCASVDEIIAALRGALPEGDSVL 941
murE PRK00139
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
 107-312 6.20e-10

UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional


Pssm-ID: 234660 [Multi-domain]  Cd Length: 460  Bit Score: 60.92  E-value: 6.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 107 IVAITGSNGKSTVTTLVGEMAKAAG--------VNVGVGGN-----------IGLPALM--LLDDECELYVLELSSFQLE 165
Cdd:PRK00139  97 LIGVTGTNGKTTTAYLLAQILRLLGektaligtLGNGIGGElipsglttpdaLDLQRLLaeLVDAGVTYAAMEVSSHALD 176

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 166 T--TSSLQAVAATILNVTEDHMDRYPfGLQQYRAAKLRIYENA-KVCVVNADDALTMPIRgADERCVSFGVNMGDYHLNH 242
Cdd:PRK00139 177 QgrVDGLKFDVAVFTNLSRDHLDYHG-TMEDYLAAKARLFSELgLAAVINADDEVGRRLL-ALPDAYAVSMAGADLRATD 254

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 110341893 243 QQgetwLRVKGEKVLNVKEMKLS--GQHNYTNALAALALADAAGLPRASSLKALTTFTGLPHRFEVVLEHNG 312
Cdd:PRK00139 255 VE----YTDSGQTFTLVTEVESPliGRFNVSNLLAALAALLALGVPLEDALAALAKLQGVPGRMERVDAGQG 322
Mur_ligase_C pfam02875
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ...
 301-370 7.81e-10

Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.


Pssm-ID: 460731 [Multi-domain]  Cd Length: 87  Bit Score: 55.43  E-value: 7.81e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 110341893  301 PHRFEVVLEHNGVRWVNDsKATNVGSTEAALNGL--HVDGTLHLLLGGDG-KSADFSPLARYLNGDNVRLYCF 370
Cdd:pfam02875   2 PGRLEVVGENNGVLVIDD-YAHNPDAMEAALRALrnLFPGRLILVFGGMGdRDAEFHALLGRLAAALADVVIL 73
PRK14016 PRK14016
cyanophycin synthetase; Provisional
 71-228 1.81e-06

cyanophycin synthetase; Provisional


Pssm-ID: 237586 [Multi-domain]  Cd Length: 727  Bit Score: 50.15  E-value: 1.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893  71 ASPGIaLAH--PSLSAAADAGIEIVGdiELFCREAQA--PIVAITGSNGKSTVTTLVGEMAKAAGVNVGVGGNIGL---- 142
Cdd:PRK14016 445 AAPGL-RMHlaPSEGKPRNVGEAIVD--MLFPEGDDGriPIVAVTGTNGKTTTTRLIAHILKLSGKRVGMTTTDGVyidg 521

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110341893 143 ----------PA---LMLLDDECELYVLE------LSS---FQLettsslqAVAATILNVTEDHM-DRYPFGLQQYRAAK 199
Cdd:PRK14016 522 rlidkgdctgPKsarRVLMNPDVEAAVLEtarggiLREglaYDR-------CDVGVVTNIGEDHLgLGGINTLEDLAKVK 594

                        170       180       190
                 ....*....|....*....|....*....|..
gi 110341893 200 LRIYENAK---VCVVNADDALTMPIRgadERC 228
Cdd:PRK14016 595 RVVVEAVKpdgYAVLNADDPMVAAMA---ERC 623
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH