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Conserved domains on  [gi|1101047393|gb|OIO10118|]
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protoheme IX farnesyltransferase [Flavobacteriaceae bacterium CG1_02_35_72]

Protein Classification

protoheme IX farnesyltransferase( domain architecture ID 10785017)

protoheme IX farnesyltransferase acts in step 1 of the conversion protoheme IX to heme O in heme O biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 15-298 3.69e-96

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


:

Pssm-ID: 439879  Cd Length: 299  Bit Score: 285.49  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  15 LNDLKQLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLS 93
Cdd:COG0109    16 LRDYLALTKPRIILLLLFTALAGMLLAAgGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRIS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  94 KNSALFIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEA 171
Cdd:COG0109    96 PREALIFGLVLGVLGLALLALfVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLEA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 172 GVLFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPV-LGLTGqlklsVVAAILT 250
Cdd:COG0109   176 LLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYlLGMAG-----LIYLVVA 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1101047393 251 VLPGLLMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVVDKFLR 298
Cdd:COG0109   251 LVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLL 298
 
Name Accession Description Interval E-value
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 15-298 3.69e-96

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 285.49  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  15 LNDLKQLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLS 93
Cdd:COG0109    16 LRDYLALTKPRIILLLLFTALAGMLLAAgGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRIS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  94 KNSALFIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEA 171
Cdd:COG0109    96 PREALIFGLVLGVLGLALLALfVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLEA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 172 GVLFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPV-LGLTGqlklsVVAAILT 250
Cdd:COG0109   176 LLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYlLGMAG-----LIYLVVA 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1101047393 251 VLPGLLMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVVDKFLR 298
Cdd:COG0109   251 LVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLL 298
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 20-290 1.04e-88

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 265.46  E-value: 1.04e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  20 QLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSAL 98
Cdd:cd13957     2 ELTKPRITLLVLLTALAGYLLAPgGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  99 FIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTPLKTV-TPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFA 176
Cdd:cd13957    82 IFGLVLGILGLALLALfVNPLTALLGLLGIFLYVFVYTPLKKRtTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 177 IQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPV-LGLTGqlklsVVAAILTVLPGL 255
Cdd:cd13957   162 ILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYlLGLTG-----WIYLVVALLLGL 236

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1101047393 256 LMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQII 290
Cdd:cd13957   237 YFLYLAIKLYRSPDDKWARKLFFASLIYLPLLFLL 271
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 17-294 5.66e-65

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 205.17  E-value: 5.66e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  17 DLKQLTKFGLSISVVFSSIAGYLL--GATIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSK 94
Cdd:TIGR01473   2 DYLQLTKPRIISLLLITAFAGMWLapGGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  95 NSALFIASIFTILGLTILY-HINPKTAFFGALSIFLYTSVYT-PLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAG 172
Cdd:TIGR01473  82 REALAFGLLLGVLGVAILAaFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGAW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 173 VLFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSvypvLGLTGQLKLSVVAAILTVL 252
Cdd:TIGR01473 162 LLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVS----LLLAFLGGTGWLYLIVATL 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1101047393 253 PGLLMLYYGLKL-RSVQTAIIARNLMLSSVFYITMIQIIFVVD 294
Cdd:TIGR01473 238 LGALFLYLAFKFyRDPTDRKKARKLFKFSLIYLALLFVALLID 280
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 17-298 4.59e-64

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 203.45  E-value: 4.59e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  17 DLKQLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKN 95
Cdd:PRK04375   12 DYLALTKPRVISLNLFTALGGMLLAPpGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  96 SALFIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGV 173
Cdd:PRK04375   92 EALIFGLVLGVLGFLLLGLfVNPLAAWLTLAGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSWEALI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 174 LFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPVLGLTGQLKLSVVAAILtvlp 253
Cdd:PRK04375  172 LFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLYLVVALLL---- 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1101047393 254 GLLMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVVDKFLR 298
Cdd:PRK04375  248 GAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLL 292
UbiA pfam01040
UbiA prenyltransferase family;
30-279 2.04e-39

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 138.51  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  30 VVFSSIAGYLLGAT-IINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILG 108
Cdd:pfam01040   1 LLIPALAGLALAAGgVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 109 LTILYHINPKTAFFGALSIFLYTsVYT-PLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFAIQFLWQFPHFW 187
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYV-LYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 188 AIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILvsVYPVLGLTGQLKLSVVAAILTVLPGLLMLYYGLKLRSV 267
Cdd:pfam01040 160 ANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALL--LLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237

                         250
                  ....*....|..
gi 1101047393 268 QTAIIARNLMLS 279
Cdd:pfam01040 238 KKDAKAFFFLSS 249
 
Name Accession Description Interval E-value
CyoE COG0109
Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport ...
 15-298 3.69e-96

Polyprenyltransferase (heme O synthase) [Coenzyme transport and metabolism, Lipid transport and metabolism];


Pssm-ID: 439879  Cd Length: 299  Bit Score: 285.49  E-value: 3.69e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  15 LNDLKQLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLS 93
Cdd:COG0109    16 LRDYLALTKPRIILLLLFTALAGMLLAAgGLPDLLLLLLTLLGGALAAGAANALNNYIDRDIDALMKRTKNRPLPTGRIS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  94 KNSALFIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEA 171
Cdd:COG0109    96 PREALIFGLVLGVLGLALLALfVNPLAALLGLLGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSLEA 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 172 GVLFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPV-LGLTGqlklsVVAAILT 250
Cdd:COG0109   176 LLLFLIIFLWTPPHFWALALKRRDDYARAGVPMLPVVKGERRTKRQILLYTLLLVPVSLLPYlLGMAG-----LIYLVVA 250

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 1101047393 251 VLPGLLMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVVDKFLR 298
Cdd:COG0109   251 LVLGAWFLYLAVRLYRRPDRKWARKLFKFSILYLTLLFLALLVDHLLL 298
PT_UbiA_Cox10 cd13957
Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O ...
 20-290 1.04e-88

Protoheme IX farnesyltransferase; Protoheme IX farnesyltransferase (also called heme O synthase, heme A:farnesyltransferase, cytochrome c oxidase subunit X [Cox10]) converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of the heme B porphyrin ring with a hydroxyethyl farnesyl side group. It is localized at the mitochondrial inner membrane. Eukaryotic Cox10 is important for the maturation of the heme A prosthetic group of cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, that catalyzes the electron transfer from reduced cytochrome c to oxygen. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260120  Cd Length: 271  Bit Score: 265.46  E-value: 1.04e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  20 QLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSAL 98
Cdd:cd13957     2 ELTKPRITLLVLLTALAGYLLAPgGVPDLLLLLLTLLGTALVSASANALNQYIERDIDAKMKRTRNRPLPSGRISPKHAL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  99 FIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTPLKTV-TPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFA 176
Cdd:cd13957    82 IFGLVLGILGLALLALfVNPLTALLGLLGIFLYVFVYTPLKKRtTPLNTVIGGIAGAIPPLIGWAAATGSLDLGAWLLFL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 177 IQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPV-LGLTGqlklsVVAAILTVLPGL 255
Cdd:cd13957   162 ILFLWQPPHFWALAILYRDDYARAGIPMLPVVKGERRTKRQILLYTLLLVPLSLLLYlLGLTG-----WIYLVVALLLGL 236

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1101047393 256 LMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQII 290
Cdd:cd13957   237 YFLYLAIKLYRSPDDKWARKLFFASLIYLPLLFLL 271
cyoE_ctaB TIGR01473
protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also ...
 17-294 5.66e-65

protoheme IX farnesyltransferase; This model describes protoheme IX farnesyltransferase, also called heme O synthase, an enzyme that creates an intermediate in the biosynthesis of heme A. Prior to the description of its enzymatic function, this protein was often called a cytochrome o ubiquinol oxidase assembly factor. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273645  Cd Length: 280  Bit Score: 205.17  E-value: 5.66e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  17 DLKQLTKFGLSISVVFSSIAGYLL--GATIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSK 94
Cdd:TIGR01473   2 DYLQLTKPRIISLLLITAFAGMWLapGGALVNPPLLLLTLLGTTLAAASANAFNMYIDRDIDKKMKRTRNRPLVTGRISP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  95 NSALFIASIFTILGLTILY-HINPKTAFFGALSIFLYTSVYT-PLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAG 172
Cdd:TIGR01473  82 REALAFGLLLGVLGVAILAaFVNPLAALLGLFGIFFYVIVYTiWLKRRTPQNTVIGGFAGAVPPLIGWAAVTGSISLGAW 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 173 VLFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSvypvLGLTGQLKLSVVAAILTVL 252
Cdd:TIGR01473 162 LLFAIIFLWQPPHFWALALKYKDDYRAAGIPMLPVVKGERITKRQIALYTAALLPVS----LLLAFLGGTGWLYLIVATL 237

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1101047393 253 PGLLMLYYGLKL-RSVQTAIIARNLMLSSVFYITMIQIIFVVD 294
Cdd:TIGR01473 238 LGALFLYLAFKFyRDPTDRKKARKLFKFSLIYLALLFVALLID 280
PRK04375 PRK04375
protoheme IX farnesyltransferase; Provisional
 17-298 4.59e-64

protoheme IX farnesyltransferase; Provisional


Pssm-ID: 235293  Cd Length: 296  Bit Score: 203.45  E-value: 4.59e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  17 DLKQLTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKN 95
Cdd:PRK04375   12 DYLALTKPRVISLNLFTALGGMLLAPpGVPPLLLLLLTLLGIALVAGAAGALNNYIDRDIDAKMERTKNRPLVTGRISPR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  96 SALFIASIFTILGLTILYH-INPKTAFFGALSIFLYTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGV 173
Cdd:PRK04375   92 EALIFGLVLGVLGFLLLGLfVNPLAAWLTLAGIFFYVVVYTLwLKRRTPQNIVIGGAAGAMPPLIGWAAVTGSLSWEALI 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 174 LFAIQFLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPVLGLTGQLKLSVVAAILtvlp 253
Cdd:PRK04375  172 LFLIIFLWTPPHFWALAIFRKDDYAAAGIPMLPVVKGIRVTKRQILLYTVLLVAVSLLPVLLGMAGLLYLVVALLL---- 247

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1101047393 254 GLLMLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVVDKFLR 298
Cdd:PRK04375  248 GAWFLYYAWRLYRKDDRKWARKLFRYSINYLTLLFVALLVDHLLL 292
PLN02776 PLN02776
prenyltransferase
 21-293 7.35e-59

prenyltransferase


Pssm-ID: 215415  Cd Length: 341  Bit Score: 191.50  E-value: 7.35e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  21 LTKFGLSISVVFSSIAGYLLGA-TIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALF 99
Cdd:PLN02776    1 LSKARLSALVVATSGAGFVLGSgEAIDLPGLGWTCAGTMLCAASANTLNQVFEVKNDSKMKRTMRRPLPSGRISVPHAVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 100 IASIFTILGLTIL-YHINPKTAFFGALSIFLYTSVYTPLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFAIQ 178
Cdd:PLN02776   81 WAVVVGAAGVALLaYKTNMLTAGLGAGNILLYAFVYTPLKQIHPANTWVGAVVGAIPPLMGWAAASGQLDAGAMVLAAAL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 179 FLWQFPHFWAIGWLLDDDYKLAGFKMLPMGTKD-KKLAIQIILYTFAMILVSVYPVL-GLTGQLkLSVVAAILTvlpgLL 256
Cdd:PLN02776  161 YFWQMPHFMALAYMCRDDYAAGGYRMLSLADATgRRTALVALRNCLYLAPLGFLAYDwGVTSSP-FALEAALLT----AY 235

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1101047393 257 MLYYGLKLRSVQTAIIARNLMLSSVFYITMIQIIFVV 293
Cdd:PLN02776  236 LAASAASFYREPTNANARKMFHGSLLYLPAFMALLLL 272
UbiA pfam01040
UbiA prenyltransferase family;
30-279 2.04e-39

UbiA prenyltransferase family;


Pssm-ID: 460038 [Multi-domain]  Cd Length: 250  Bit Score: 138.51  E-value: 2.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  30 VVFSSIAGYLLGAT-IINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILG 108
Cdd:pfam01040   1 LLIPALAGLALAAGgVPDLLLLLLALLGTVLARAAANALNDYYDRDIDAIMPRTPNRPLPSGRISPREALIFALVLLALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 109 LTILYHINPKTAFFGALSIFLYTsVYT-PLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFAIQFLWQFPHFW 187
Cdd:pfam01040  81 LLLLLLLNPLTALLGLAALLLYV-LYTlRLKRRTLLGQLVGGLAFGLPPLLGWAAVTGSLSPLALLLALALFLWTWAIAL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 188 AIGWLLDDDYKLAGFKMLPMGTKDKKLAIQIILYTFAMILvsVYPVLGLTGQLKLSVVAAILTVLPGLLMLYYGLKLRSV 267
Cdd:pfam01040 160 ANDLRDREDDRKAGIKTLPVVLGRKAARILLALLLAVALL--LLLLLLLLLLGGLYLLLALLLAALALLYAARLLRLRDP 237

                         250
                  ....*....|..
gi 1101047393 268 QTAIIARNLMLS 279
Cdd:pfam01040 238 KKDAKAFFFLSS 249
UbiA COG0382
4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate ...
 35-282 2.08e-15

4-hydroxybenzoate polyprenyltransferase [Coenzyme transport and metabolism]; 4-hydroxybenzoate polyprenyltransferase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 440151  Cd Length: 280  Bit Score: 74.50  E-value: 2.08e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  35 IAGYLLGATIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILGLTILYH 114
Cdd:COG0382    24 WALFLAAGGLPDLLLLLLAVLGTVLMRSAGYVINDYFDREIDRINERKPNRPLASGRISLREALLLAIVLLLLALALALL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 115 INPKTAFFGALSIFLyTSVYTP-LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFAIQFLWQFPH--FWAIGW 191
Cdd:COG0382   104 LNPLTFLLALAALAL-AWAYSLfLKRFTLLGNLVLGLLFGLGILMGFAAVTGSLPLSAWLLALAAFLWTLAYdtIYDLED 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 192 LLDDdyKLAGFKMLPMGTKDKKLAIQIILYTFAMILVSVYPVLgLTGQLKLSVVAAILTVLPGLLMLYYGLKLRSVQTAI 271
Cdd:COG0382   183 REGD--RKIGIKTLAILFGVRDALIIAGVLYALAVLLLLLLGL-LAGLGLLYLLGLLAALLLLYLSQLWLLRPRKKDPAR 259

                         250
                  ....*....|.
gi 1101047393 272 IARNLMLSSVF 282
Cdd:COG0382   260 ALKLFKLNMLL 270
PT_UbiA_COQ2 cd13959
4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known ...
 49-181 2.88e-15

4-Hydroxybenzoate polyprenyltransferase; 4-Hydroxybenzoate polyprenyltransferase, also known as Coq2, catalyzes the prenylation of p-hydroxybenzoate with an all-trans polyprenyl group, an important step in ubiquinone (CoQ) biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260122 [Multi-domain]  Cd Length: 272  Bit Score: 74.04  E-value: 2.88e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  49 ILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILGLTILYHINPKTAFFGALSIF 128
Cdd:cd13959    34 LLLLFLLGAFLMRSAGCTINDIADRDIDAKVPRTKNRPLASGAISVKEALLFLAVQLLLGLALLLQLNPLTILLSPIALL 113

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1101047393 129 LYTsVYTPLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVLFAIQFLW 181
Cdd:cd13959   114 LVL-IYPLMKRFTYWPQLVLGLAFGWGPLMGWAAVTGSLPLPALLLYLAVIFW 165
PT_UbiA cd13956
UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA ...
 20-284 1.89e-08

UbiA family of prenyltransferases (PTases); Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260119 [Multi-domain]  Cd Length: 271  Bit Score: 54.28  E-value: 1.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  20 QLTKFGLSISVVFSSIAGYLLGATIINY--EILILLALGGYLMVGASNAFNQVIEIKQDALMKRTktRPLPTGRLSKNSA 97
Cdd:cd13956     2 RLMRPYTLLYVLAPALAGAALAGAFAGPlpALLLLALLAVFLGAGAGYALNDYTDRELDAINKPD--RPLPSGRLSPRQA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  98 LFIASIFTILGLTILYHINPKTA---FFGALSIFLYTsvYTPLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVL 174
Cdd:cd13956    80 LAFAAALLLVGLALALALGPLALlllLAGLLLGLAYS--LGLKRLKLGGWGVLGYATGLALLPGLGAVAAGGLVPLALLL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 175 FAIQFLWQFP-HFWAIGWLLDDDYKlAGFKMLPMGTKDKKLAIQIILYTFAMILVSVypVLGLTGQLKLSVVAAILTVLP 253
Cdd:cd13956   158 ALVFLLLGLGiNLYNDLPDVEGDRA-AGIRTLPVRLGPRRARRLAAGLLLAALILVV--LLAVAGLLGPLALLALLAVAL 234

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1101047393 254 GLLMLYYGLKLRSVQTAIIARNLMLSSVFYI 284
Cdd:cd13956   235 LALRARFARADRLPALPRGFLLLAVYRLLLF 265
PLN02809 PLN02809
4-hydroxybenzoate nonaprenyltransferase
 46-162 1.24e-06

4-hydroxybenzoate nonaprenyltransferase


Pssm-ID: 178405  Cd Length: 289  Bit Score: 48.92  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  46 NYEILILLALGGYLMVGASNAFNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILGLTILYHINPKTAFFGAL 125
Cdd:PLN02809   43 DLKMLALFGCGALLLRGAGCTINDLLDRDIDKKVERTKLRPIASGALTPFQGVGFLGAQLLLGLGILLQLNNYSRILGAS 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1101047393 126 SIFLYTSvYTPLKTVT--PLAVFVGAFP-GAIpfmLGWVA 162
Cdd:PLN02809  123 SLLLVFT-YPLMKRFTfwPQAFLGLTFNwGAL---LGWAA 158
ubiA PRK12884
prenyltransferase; Reviewed
 15-180 3.05e-06

prenyltransferase; Reviewed


Pssm-ID: 183812  Cd Length: 279  Bit Score: 47.64  E-value: 3.05e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  15 LNDLKQLTKFGLSISVVFSSIAGYLLGATIINYEILILLALGGYLMVGASNAFNQVIEIKQDAlmKRTKTRPLPTGRLSK 94
Cdd:PRK12884    4 MKAYLELLRPEHGLMAGIAVVLGAIIALGGLPLDEALLGFLTAFFASGSANALNDYFDYEVDR--INRPDRPIPSGRISR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  95 NSALFIASIFTILGLTILYHINPKTAFFGALSIFLYTSVYTPLKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAgVL 174
Cdd:PRK12884   82 REALLLAILLFILGLIAAYLISPLAFLVVILVSVLGILYNWKLKEYGLIGNLYVAFLTGMTFIFGGIAVGELNEAVI-LL 160


                  ....*.
gi 1101047393 175 FAIQFL 180
Cdd:PRK12884  161 AAMAFL 166
PT_UbiA_DGGGPS cd13961
Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate ...
 20-180 6.47e-05

Geranylgeranylglycerol-phosphate geranylgeranyltransferase; Digeranylgeranylglyceryl phosphate synthase (DGGGPS) transfers a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate, as part of the isoprenoid ether lipid biosynthesis. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways.


Pssm-ID: 260124  Cd Length: 270  Bit Score: 43.65  E-value: 6.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  20 QLTKFGLSISVVFSSIAGYLL---GATIINYEILILLALGGYLMVGASNAFNQVIEIKQDALMKrtKTRPLPTGRLSKNS 96
Cdd:cd13961     4 ELIRPPNLLMAALAQYLGALFalgPLLSLNDLELLLLFLSVFLIAAAGYIINDYFDVEIDRINK--PDRPIPSGRISRRE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  97 ALFIASIFTILGLTILYHINPKTAFFGALSIFL---YTSVYTPLKTVTPLAVfvgAFPGAIPFMLGWVAATNHFGIeAGV 173
Cdd:cd13961    82 ALILSILLNALGLILAFLLSPLALLIALLNSLLlwlYSHKLKRTPLIGNLLV---ALLTGLPFLFGGLAAGNLLLI-ILL 157


                  ....*..
gi 1101047393 174 LFAIQFL 180
Cdd:cd13961   158 LALFAFL 164
ubiA PRK12886
prenyltransferase; Reviewed
 60-264 9.33e-05

prenyltransferase; Reviewed


Pssm-ID: 237247  Cd Length: 291  Bit Score: 43.14  E-value: 9.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  60 MVGASNA---FNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILGLTILYHINPKTAFFGALSIFLYTsVYTP 136
Cdd:PRK12886   51 MVGARTAamgFNRLIDAEIDARNPRTAGRAIPAGLISKGSAILFIVLSSLLMLFAAWFLNPLCLYLSPPALFFLL-LYSY 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393 137 LKTVTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAgVLFAIQFLwqfphFWaigwlldddykLAGFKMLpmgtkdkkLAI 216
Cdd:PRK12886  130 CKRFTALAHVVLGFCLALAPLGAWIAIRGTIELPA-ILLGLAVL-----FW-----------VAGFDIL--------YAL 184

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1101047393 217 QIILYTFAMILVSVYPVLGLTGQLKLSVVAAILTVLPgLLMLYYGLKL 264
Cdd:PRK12886  185 QDLEFDRKEGLHSIPAKLGVNGSLWIARVFHLLMIGF-LFALGISAGL 231
PT_UbiA_1 cd13964
UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of ...
 35-174 1.47e-03

UbiA family of prenyltransferases (PTases), Unknown subgroup; Many characterized members of the UbiA prenyltransferase family are aromatic prenyltransferases and play an important role in the biosynthesis of heme, chlorophyll, vitamin E, and vitamin K. They contain two copies of a motif similar to the active site DxxD motif of trans-prenyltransferases and are potentially related. Prenyltransferases (PTs) catalyze the regioselective transfer of prenyl moieties onto a wide variety of substrates and play an important role in many biosynthetic pathways. The function of this subgroup is unknown.


Pssm-ID: 260127  Cd Length: 282  Bit Score: 39.49  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  35 IAGYLLGATIINYEI-LILLALGGYLMVGASNAFNQVIEIKQDALMKRTktRPLPTGRLSKNSALFIASIFTILGLTILY 113
Cdd:cd13964    18 LAGAALAGGGLGPVLrLALLLLASVLLYAAGMVLNDVFDAELDARERPE--RPIPSGRVSRGAALALGAGLLAAGVALAA 95

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1101047393 114 HINPKTAFFG---ALSIFLYTSvytPLKTvTPLAVFVGAFPGAIPFMLGWVAATNHFGIEAGVL 174
Cdd:cd13964    96 LVGRLSGLVAlllAAAILLYDA---WLKH-TPLGPLLMGLCRGLNLLLGASAAAAGGLGPALLA 155
ubiA PRK12882
prenyltransferase; Reviewed
 20-180 2.58e-03

prenyltransferase; Reviewed


Pssm-ID: 183811  Cd Length: 276  Bit Score: 38.80  E-value: 2.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  20 QLTKFGLSISVVFSSIAGYLLGATIINYEILILLALGG-YLMVGASNAFNQVIEIKQDALMKrtKTRPLPTGRLSKNSAL 98
Cdd:PRK12882    9 ELTRPVNAVVAGVAAFIGAFIAGGILSSPSLTGLAFAAvFLATGAGNAINDYFDREIDRINR--PDRPIPSGAVSPRGAL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  99 FIASIFTILGLTILYHINPKT---AFFGALSIFLYTSVytpLKTvTPLA--VFVGAFPGAIpFMLGWVAATNHFGIEAGV 173
Cdd:PRK12882   87 AFSILLFAAGVALAFLLPPLClaiALFNSLLLVLYAET---LKG-TPGLgnASVAYLTGST-FLFGGAAVGTEGLLALLV 161


                  ....*..
gi 1101047393 174 LFAIQFL 180
Cdd:PRK12882  162 LFALAAL 168
PRK09573 PRK09573
(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed
 30-140 2.63e-03

(S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase; Reviewed


Pssm-ID: 181963  Cd Length: 279  Bit Score: 38.79  E-value: 2.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1101047393  30 VVFSSIAGYLLGATIINYEI----LILLALGGYLMVGASNAFNQVIEIKQDALMKrtKTRPLPTGRLSKNSALFIASIFT 105
Cdd:PRK09573   15 CIGASIGAIIGYLIASNFKIdlkgIILAALVVFLVCAGGNVINDIYDIEIDKINK--PERPIPSGRISLKEAKIFSITLF 92

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1101047393 106 ILGLTILYHINPKT---AFFGALSIFLYTSVYTPLKTV 140
Cdd:PRK09573   93 IVGLILSIFINIYAfliALLNSILLYLYAKDLKKTGLI 130
PRK12324 PRK12324
decaprenyl-phosphate phosphoribosyltransferase;
67-121 8.55e-03

decaprenyl-phosphate phosphoribosyltransferase;


Pssm-ID: 237058  Cd Length: 295  Bit Score: 37.15  E-value: 8.55e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1101047393  67 FNQVIEIKQDALMKRTKTRPLPTGRLSKNSALFIASIFTILGLTILYHINPKTAF 121
Cdd:PRK12324   65 VNDIRDVEADRLHPTKRNRPIASGVVSVSLAYILAVVLLVASLALAYLLSPKLAL 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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