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Conserved domains on  [gi|1100818962|ref|NP_001333845|]
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zinc finger protein 429 isoform d [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-560 2.23e-17

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 165 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 241
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 242 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 321
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 322 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 396
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 397 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 469
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 470 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 538
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818962 539 NRSSRLTQHKKIHTREKPYKCE 560
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-560 2.23e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 165 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 241
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 242 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 321
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 322 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 396
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 397 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 469
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 470 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 538
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818962 539 NRSSRLTQHKKIHTREKPYKCE 560
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-428 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818962 403 HLTSHRRIHTGEKPYKCEECGKAFKQ 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-560 2.23e-17

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 85.13  E-value: 2.23e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 165 YRCEECGKAFNHYSTLTNHKRIHTGEKPYKC--KECGKAFSRYSTLTTHKRIHSGEKPYKC-DECGKTFSISSTFTKHKI 241
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 242 IHTEEKPYKCKECGKAFNRSSTLTSHKRIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCEECGKAFNQSSRLT 321
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISSNVS 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 322 ----RHKKIHTGEEPYKFEKCGRVFTCSSTLTQDKKIH-TGEKPYNCEECGKVFTYSSTLTRHKRIHteekpYKCNECGK 396
Cdd:COG5048   194 tsipSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnSQLSPKSLLSQSPSSLSSSDSSSSASES-----PRSSLPTA 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 397 AFNRSSHLTSHRRIHTG-EKPYKCEECGKAFKQSSNLNSHK--KIHSGE--KPYKCEE--CGKAFILSSRLTQHKKIHTG 469
Cdd:COG5048   269 SSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 470 EKPYKC--EECGKAFNRSSR-----LTQHKKIHTGEKPYKC--KQCDKAFTHSSNLSSHKKIHSGEKP--YKCEECGKAF 538
Cdd:COG5048   349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                         410       420
                  ....*....|....*....|..
gi 1100818962 539 NRSSRLTQHKKIHTREKPYKCE 560
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
219-580 2.55e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 2.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 219 KPYKCDECGKTFSISSTFTKHKIIHTEEKPYKC--KECGKAFNRSSTLTSHKRIHTGEKPYKCE-ECGKAFNWSSTLTKH 295
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 296 KVIHTGEKPYKCEECGKAFNQSSRLTRHKKIHTGEEPYKFEKCGRVFTCSStltQDKKIHtgeKPYNCEECGKVFTYSST 375
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTP---QSNSLH---PPLPANSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 376 LTRHKRIHTEEKPYKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNSHKKIHSGEKPYKCEECGKAFI 455
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 456 LSSRLTQHKKIHTGE-------KPYKCEECGKAFNRSSRLTQHK--KIHTGE--KPYKC--KQCDKAFTHSSNLSSHKKI 522
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1100818962 523 HSGEKPYKC--EECGKAFNRSSR-----LTQHKKIHTREKPYKCE--ECAKAFTRSSRLTQHKKIHR 580
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHL 412
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 469-549 2.39e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 469 GEKPYKCE--ECGKAFNRSSRLTQHKKiHtgekpykcKQCDKAFTHSSNLSSHKKIHSGEKPYKCEECGKAFNRSSRLTQ 546
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1100818962 547 HKK 549
Cdd:COG5189   417 HRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 497-577 3.44e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 3.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 497 GEKPYKCK--QCDKAFTHSSNLSSHKKiHSGEKPYKCEECGKafnrssrlTQHKKIHTREKPYKCEECAKAFTRSSRLTQ 574
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ...
gi 1100818962 575 HKK 577
Cdd:COG5189   417 HRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
403-428 4.77e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.77e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818962 403 HLTSHRRIHTGEKPYKCEECGKAFKQ 428
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 373-465 4.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.91e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 373 SSTLTRHKRIHTEEKPYKCNECGKAFNRSSHL---TSHRRIHT-GEKPYKCE--ECGKAFKQSSNLNSHKK--------- 437
Cdd:COG5189   302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklh 381

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1100818962 438 ----------IHSGEKPYKCEECGKAFILSSRLTQHKK 465
Cdd:COG5189   382 enpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 357-440 5.54e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 5.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 357 GEKPYNCE--ECGKVFTYSSTLTRHKrihteekpyKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQSSNLNS 434
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1100818962 435 HKKiHS 440
Cdd:COG5189   417 HRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
487-512 7.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.34e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818962 487 RLTQHKKIHTGEKPYKCKQCDKAFTH 512
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
515-540 8.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 8.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818962 515 NLSSHKKIHSGEKPYKCEECGKAFNR 540
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
459-484 9.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1100818962 459 RLTQHKKIHTGEKPYKCEECGKAFNR 484
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
180-204 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1100818962 180 LTNHKRIHTGEKPYKCKECGKAFSR 204
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-400 1.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.13e-03
                          10        20
                  ....*....|....*....|....*
gi 1100818962 376 LTRHKRIHTEEKPYKCNECGKAFNR 400
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
505-582 1.29e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 505 QCDKAFTHSSNlSSHKKIHSGEKPYKCEECGKAFNRSSRLTQHKKIHTREKPYKC--EECAKAFTRSSRLTQHKKIHRMG 582
Cdd:COG5048    11 SNNSVLSSTPK-STLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNN 89
zf-H2C2_2 pfam13465
Zinc-finger double domain;
264-287 1.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.42e-03
                          10        20
                  ....*....|....*....|....
gi 1100818962 264 LTSHKRIHTGEKPYKCEECGKAFN 287
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
431-454 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....
gi 1100818962 431 NLNSHKKIHSGEKPYKCEECGKAF 454
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 232-325 4.11e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 4.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 232 ISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTL---TSHKRIHT-GEKPYKCE--ECGKAFNWSSTLTKHK--------- 296
Cdd:COG5189   301 IRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERnidTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHMlhghqnqkl 380

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1100818962 297 ----------VIHTGEKPYKCEECGKAFNQSSRLTRHKK 325
Cdd:COG5189   381 henpspekmnIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
292-316 4.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.93e-03
                          10        20
                  ....*....|....*....|....*
gi 1100818962 292 LTKHKVIHTGEKPYKCEECGKAFNQ 316
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-231 4.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.98e-03
                          10        20
                  ....*....|....*....|....
gi 1100818962 208 LTTHKRIHSGEKPYKCDECGKTFS 231
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 189-268 6.74e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 6.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1100818962 189 GEKPYKCK--ECGKAFSRYSTLTTHKrihsgekpyKCDECGKTFSISSTFTKHKIIHTEEKPYKCKECGKAFNRSSTLTS 266
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1100818962 267 HK 268
Cdd:COG5189   417 HR 418
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 389-411 7.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.56e-03
                          10        20
                  ....*....|....*....|...
gi 1100818962 389 YKCNECGKAFNRSSHLTSHRRIH 411
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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