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Conserved domains on  [gi|109809757|ref|NP_001035954|]
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voltage-gated hydrogen channel 1 [Mus musculus]

Protein Classification

cyclic nucleotide-gated ion channel( domain architecture ID 13585936)

cyclic nucleotide-gated ion channel is a nonselective channel that is opened by the direct binding of cyclic nucleotides, cAMP and cGMP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 222-269 2.64e-23

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


:

Pssm-ID: 465275  Cd Length: 48  Bit Score: 89.62  E-value: 2.64e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 109809757  222 RQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN 269
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
Ion_trans super family cl37996
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 125-191 6.70e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


The actual alignment was detected with superfamily member pfam00520:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 36.86  E-value: 6.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109809757  125 PDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRL--EFFHHKFEILDaFVVVVSFVLDLVLLFKSHHF 191
Cdd:pfam00520  25 FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILD-FVVVLPSLISLVLSSVGSLS 92
 
Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 222-269 2.64e-23

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


Pssm-ID: 465275  Cd Length: 48  Bit Score: 89.62  E-value: 2.64e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 109809757  222 RQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN 269
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 125-191 6.70e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 36.86  E-value: 6.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109809757  125 PDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRL--EFFHHKFEILDaFVVVVSFVLDLVLLFKSHHF 191
Cdd:pfam00520  25 FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILD-FVVVLPSLISLVLSSVGSLS 92
 
Name Accession Description Interval E-value
VGPC1_C pfam16799
C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal ...
 222-269 2.64e-23

C-terminal membrane-localization domain of ion-channel, VCN1; VCN1_C is the short C-terminal region of voltage-gated proton channel 1 proteins in higher eukaryotes. The domain is necessary for achieving the dimeric architecture, two monomers form a dimer via parallel alpha-helical coiled-coil interaction. but it is also essential for localising the protein to an intracellular membrane.


Pssm-ID: 465275  Cd Length: 48  Bit Score: 89.62  E-value: 2.64e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 109809757  222 RQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN 269
Cdd:pfam16799   1 QQLSRLKQMNLQLAAKIQHLEFSCSEKEQEIERLNKLLKQHGLLLQQE 48
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 125-191 6.70e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 36.86  E-value: 6.70e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 109809757  125 PDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRL--EFFHHKFEILDaFVVVVSFVLDLVLLFKSHHF 191
Cdd:pfam00520  25 FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkkRYFRSPWNILD-FVVVLPSLISLVLSSVGSLS 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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