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Conserved domains on  [gi|1093537106|ref|WP_070876393|]
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3-isopropylmalate dehydrogenase [Metabacillus idriensis]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 610.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   1 MEKKIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  81 KNPSHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDT 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 161 LFYKRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIV 240
Cdd:PRK00772  161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 241 TENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIEN 320
Cdd:PRK00772  241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1093537106 321 AVKHVLDSGKRTADLTrKGETPLSTSKLVEEIKAALAD 358
Cdd:PRK00772  321 AVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALAE 357
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 610.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   1 MEKKIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  81 KNPSHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDT 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 161 LFYKRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIV 240
Cdd:PRK00772  161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 241 TENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIEN 320
Cdd:PRK00772  241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1093537106 321 AVKHVLDSGKRTADLTrKGETPLSTSKLVEEIKAALAD 358
Cdd:PRK00772  321 AVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-356 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 532.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   3 KKIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDkn 82
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 pSHLRPEKGLLALRKELDLYANLRPVETVESLldSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDTLF 162
Cdd:COG0473    80 -DGVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 163 YKRDEMERIIERAFQLAQDRKKKVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIVT 241
Cdd:COG0473   157 YTRKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 242 ENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSfKMEEEAEAIENA 321
Cdd:COG0473   237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1093537106 322 VKHVLDSGKRTADLtrkGETpLSTSKLVEEIKAAL 356
Cdd:COG0473   316 VEKVLAEGVRTPDL---GGK-AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 531.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKNP 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  84 SHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNvknGEHTVVDTLFY 163
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGRE---GEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 164 KRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIVTEN 243
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 244 MFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENAVK 323
Cdd:TIGR00169 238 LFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVK 317

                         330       340
                  ....*....|....*....|....*....
gi 1093537106 324 HVLDSGKRTADLTRKGETPLSTSKLVEEI 352
Cdd:TIGR00169 318 KVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 3.90e-177

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 495.66  E-value: 3.90e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDknP 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  84 SHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREyVEGVDFMIVRELTGGLYFGKPSERNVkNGEHTVVDTLFY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKG-SGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 164 KRDEMERIIERAFQLAQDR-KKKVTSVDKANVLESSRMWREVAEEVA-MKFPDVELQHMLVDHAAMALIHNPKQFDVIVT 241
Cdd:pfam00180 157 SRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 242 ENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENA 321
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1093537106 322 VKHVLDSGKRTADLTRKGeTPLSTSKLVEEI 352
Cdd:pfam00180 317 VLKVLESGIRTGDLAGSA-TYVSTSEFGEAV 346
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-353 2.29e-87

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 266.98  E-value: 2.29e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   3 KKIALLPGDGIGKEVMDGAVEILKAIEEHyyhrFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKN 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDALDLN----FDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 PshlrpekgLLALRKELDLYANLRPV---ETVESLLDssplkreyveGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVD 159
Cdd:NF040626   78 P--------IITLRKELDLYANLRPIksyEGINCLFK----------DLDFLIVRENTEGLYSGLEEEYTEEKAIAERVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 160 TlfykRDEMERIIERAFQLA-QDRKKKVTSVDKANVLESSR-MWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:NF040626  140 T----RKASERICKFAFEYAiKLGRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLSATGlHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:NF040626  216 VIVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANK 293

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1093537106 318 IENAVKHVLDSGK-RTADLtrkGETpLSTSKLVEEIK 353
Cdd:NF040626  294 LENALEKVLREGKvVTPDL---GGN-AKTMEMANEIK 326
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-352 7.41e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 252.76  E-value: 7.41e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIeehyyHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWD--K 81
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTelK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  82 NPSHLRPekgLLALRKELDLYANLRPVETVESLLDssplkreyVEGVDFMIVRELTGGLYFGKpsERNVKNGEHTVVDTL 161
Cdd:NF040619   78 NKNYKSP---ILTLRKELDLYANVRPINNFGDGQD--------VKNIDFVIIRENTEGLYVGR--EYYDEENEIAIAERI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 162 FYKRDEmERIIERAFQLA-QDRKKKVTSVDKANVLE-SSRMWREVAEEVAMKF--PDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:NF040619  145 ISKKGS-ERIIKFAFEYAkKNNRKKVSCIHKANVLRvTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFD 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLsATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:NF040619  224 VIVTTNLFGDILSDEASGLIGGLGLAPSANI-GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGDL 301

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1093537106 318 IENAVKHVLDSGKRTADLTRKgetpLSTSKLVEEI 352
Cdd:NF040619  302 IREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 1-358 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 610.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   1 MEKKIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWD 80
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  81 KNPSHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDT 160
Cdd:PRK00772   81 NLPPDVRPERGLLALRKELGLFANLRPAKLYPGLADASPLKPEIVAGLDILIVRELTGGIYFGEPRGREGLGGEERAFDT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 161 LFYKRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIV 240
Cdd:PRK00772  161 MVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDVIV 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 241 TENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIEN 320
Cdd:PRK00772  241 TENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAIEA 320

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1093537106 321 AVKHVLDSGKRTADLTrKGETPLSTSKLVEEIKAALAD 358
Cdd:PRK00772  321 AVEKVLAQGYRTADIA-EGGGKVSTSEMGDAILAALAE 357
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 3-356 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 532.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   3 KKIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDkn 82
Cdd:COG0473     2 YKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKWD-- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 pSHLRPEKGLLALRKELDLYANLRPVETVESLldSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDTLF 162
Cdd:COG0473    80 -DGVRPESGLLALRKELDLYANLRPAKLYPGL--PSPLKPEIVEGIDLVIVRENTEGLYFGIGGRIGTGTGEEVAIDTRV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 163 YKRDEMERIIERAFQLAQDRKKKVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIVT 241
Cdd:COG0473   157 YTRKGIERIARYAFELARKRRKKVTSVDKANVLKlTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 242 ENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSfKMEEEAEAIENA 321
Cdd:COG0473   237 ENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRHL-GEEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1093537106 322 VKHVLDSGKRTADLtrkGETpLSTSKLVEEIKAAL 356
Cdd:COG0473   316 VEKVLAEGVRTPDL---GGK-AGTSEMGDAIIAAL 346
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 4-352 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 531.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKNP 83
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  84 SHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNvknGEHTVVDTLFY 163
Cdd:TIGR00169  81 RDQRPEQGLLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIAKGVDFVVVRELTGGIYFGEPKGRE---GEGEAWDTEVY 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 164 KRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIVTEN 243
Cdd:TIGR00169 158 TVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVTSN 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 244 MFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENAVK 323
Cdd:TIGR00169 238 LFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAAVK 317

                         330       340
                  ....*....|....*....|....*....
gi 1093537106 324 HVLDSGKRTADLTRKGETPLSTSKLVEEI 352
Cdd:TIGR00169 318 KVLAEGYRTPDLGSSATTAVGTAEMGEEL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
4-352 3.90e-177

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 495.66  E-value: 3.90e-177
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDknP 83
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  84 SHLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREyVEGVDFMIVRELTGGLYFGKPSERNVkNGEHTVVDTLFY 163
Cdd:pfam00180  79 AGVRPENGLLALRKELGLFANLRPAKVFPPLGDASPLKNE-VEGVDIVIVRELTGGIYFGIEKGIKG-SGNEVAVDTKLY 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 164 KRDEMERIIERAFQLAQDR-KKKVTSVDKANVLESSRMWREVAEEVA-MKFPDVELQHMLVDHAAMALIHNPKQFDVIVT 241
Cdd:pfam00180 157 SRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAkAEYPDVELEHQLVDNAAMQLVKNPSQFDVIVT 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 242 ENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENA 321
Cdd:pfam00180 237 PNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIEAA 316

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1093537106 322 VKHVLDSGKRTADLTRKGeTPLSTSKLVEEI 352
Cdd:pfam00180 317 VLKVLESGIRTGDLAGSA-TYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 5-352 6.45e-120

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 352.84  E-value: 6.45e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   5 IALLPGDGIGKEVMDGAVEILKAIEEHYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKNPS 84
Cdd:PLN02329   49 IALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWDKNEK 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  85 HLRPEKGLLALRKELDLYANLRPVETVESLLDSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNV-KNGEHTVVDTLFY 163
Cdd:PLN02329  129 HLRPEMALFYLRRDLKVFANLRPATVLPQLVDASTLKKEVAEGVDMMIVRELTGGIYFGEPRGITInENGEEVGVSTEIY 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 164 KRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIVTEN 243
Cdd:PLN02329  209 AAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFDTIVTNN 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 244 MFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENAVK 323
Cdd:PLN02329  289 IFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKRIEDAVV 368

                         330       340
                  ....*....|....*....|....*....
gi 1093537106 324 HVLDSGKRTADLTRKGETPLSTSKLVEEI 352
Cdd:PLN02329  369 DALNKGFRTGDIYSPGNKLVGCKEMGEEV 397
LEU3_arch TIGR02088
isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal ...
 5-352 4.22e-88

isopropylmalate/isohomocitrate dehydrogenases; This model represents a group of archaeal decarboxylating dehydrogenases which include the leucine biosynthesis enzyme 3-isopropylmalate dehydrogenase (LeuB, LEU3) and the methanogenic cofactor CoB biosynthesis enzyme isohomocitrate dehydrogenase (AksF). Both of these have been characterized in Methanococcus janaschii. Non-methanogenic archaea have only one hit to this model and presumably this is LeuB, although phylogenetic trees cannot establish which gene is which in the methanogens. The AksF gene is capable of acting on isohomocitrate, iso(homo)2-citrate and iso(homo)3-citrate in the successive elongation cycles of coenzyme B (7-mercaptoheptanoyl-threonine phosphate). This family is closely related to both the LeuB genes found in TIGR00169 and the mitochondrial eukaryotic isocitrate dehydratases found in TIGR00175. All of these are included within the broader subfamily model, pfam00180.


Pssm-ID: 273962  Cd Length: 322  Bit Score: 268.56  E-value: 4.22e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   5 IALLPGDGIGKEVMDGAVEILKAieehYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKwdkNPS 84
Cdd:TIGR02088   1 VAVIPGDGIGPEVIEAAIRILNK----LGLEIEFIEFEAGDEALKKYGSALPEDTLEEIRKADAILFGAVTTPA---NPG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  85 HLRPekgLLALRKELDLYANLRPVETVESLLDSSPLkreyveGVDFMIVRELTGGLYFGKpsERNvknGEHTVVDTLFYK 164
Cdd:TIGR02088  74 YKSV---IVTLRKELDLYANVRPAKSLPGIPDLYPN------GKDIVIVRENTEGLYAGF--EFG---FSDRAIAIRVIT 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 165 RDEMERIIERAFQLAQDRKKKVTSVDKANVLESSR-MWREVAEEVAmKFPDVELQHMLVDHAAMALIHNPKQFDVIVTEN 243
Cdd:TIGR02088 140 REGSERIARFAFNLAKERNRKVTCVHKANVLKGTDgLFREVCREIA-KRYGVEYRDMYVDSAAMNLVKDPWRFDVIVTTN 218

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 244 MFGDILSDEASMLTGSLGMLPSASLSATgLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKmEEEAEAIENAVK 323
Cdd:TIGR02088 219 MFGDILSDLASALAGSLGLAPSANIGDR-KALFEPVHGSAPDIAGKGIANPTAAILSVAMMLDYLGE-LEKGKLVWEAVE 296

                         330       340
                  ....*....|....*....|....*....
gi 1093537106 324 HVLDSGKRTADLtrkGETpLSTSKLVEEI 352
Cdd:TIGR02088 297 YYIIEGKKTPDL---GGT-AKTKEVGDEI 321
AksF2_Meth NF040626
homoisocitrate dehydrogenase;
3-353 2.29e-87

homoisocitrate dehydrogenase;


Pssm-ID: 468598  Cd Length: 332  Bit Score: 266.98  E-value: 2.29e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   3 KKIALLPGDGIGKEVMDGAVEILKAIEEHyyhrFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKN 82
Cdd:NF040626    2 YKITVIPGDGIGKEVMEAALYVLDALDLN----FDFIEAEAGRECFKKNGTTIPEETIKIAKKSDATLFGAVTSTPGQKS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 PshlrpekgLLALRKELDLYANLRPV---ETVESLLDssplkreyveGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVD 159
Cdd:NF040626   78 P--------IITLRKELDLYANLRPIksyEGINCLFK----------DLDFLIVRENTEGLYSGLEEEYTEEKAIAERVI 139

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 160 TlfykRDEMERIIERAFQLA-QDRKKKVTSVDKANVLESSR-MWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:NF040626  140 T----RKASERICKFAFEYAiKLGRKKVTAVHKANVLKKTDgIFKDTFYKVAKDYPQIETEDYYVDATAMYLITKPQDFD 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLSATGlHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:NF040626  216 VIVTTNLFGDILSDEAAGLVGGLGLAPSANIGDKN-GLFEPVHGSAPDIAGKNIANPIAMILSASMMLDY-LGETYEANK 293

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1093537106 318 IENAVKHVLDSGK-RTADLtrkGETpLSTSKLVEEIK 353
Cdd:NF040626  294 LENALEKVLREGKvVTPDL---GGN-AKTMEMANEIK 326
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 3-356 5.33e-87

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 266.23  E-value: 5.33e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   3 KKIALLPGDGIGKEVMDGAVEILKAIEEHyyhrFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWDKn 82
Cdd:PRK14025    2 HKICVIEGDGIGKEVVPAALHVLEATGLP----FEFVYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAGETAADV- 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 pshlrpekgLLALRKELDLYANLRPVETVESLLDSSPlkreyveGVDFMIVRELTGGLYFGKPSErnvkNGEHTVVDTLF 162
Cdd:PRK14025   77 ---------IVKLRRILDTYANVRPVKSYKGVKCLYP-------DIDYVIVRENTEGLYKGIEAE----IADGVTVATRV 136

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 163 YKRDEMERIIERAFQLAQDRKK-----KVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQF 236
Cdd:PRK14025  137 ITRKASERIFRFAFEMAKRRKKmgkegKVTCAHKANVLKkTDGLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQTF 216

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 237 DVIVTENMFGDILSDEASMLTGSLGMLPSASLSATGlHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAE 316
Cdd:PRK14025  217 DVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDKY-GLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEEAD 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1093537106 317 AIENAVKHVLDSGKRTADLtrkGETpLSTSKLVEEIKAAL 356
Cdd:PRK14025  295 KVEKALEEVLALGLTTPDL---GGN-LSTMEMAEEVAKRV 330
AksF_Meth NF040619
homoisocitrate dehydrogenase;
4-352 7.41e-82

homoisocitrate dehydrogenase;


Pssm-ID: 468591  Cd Length: 332  Bit Score: 252.76  E-value: 7.41e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIeehyyHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWD--K 81
Cdd:NF040619    3 KICVIEGDGIGKEVIPETVRVLKEL-----GDFEFIKGEAGLECFKKYGDAIPEETIEKAKECDAILFGAVTTPKPTelK 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  82 NPSHLRPekgLLALRKELDLYANLRPVETVESLLDssplkreyVEGVDFMIVRELTGGLYFGKpsERNVKNGEHTVVDTL 161
Cdd:NF040619   78 NKNYKSP---ILTLRKELDLYANVRPINNFGDGQD--------VKNIDFVIIRENTEGLYVGR--EYYDEENEIAIAERI 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 162 FYKRDEmERIIERAFQLA-QDRKKKVTSVDKANVLE-SSRMWREVAEEVAMKF--PDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:NF040619  145 ISKKGS-ERIIKFAFEYAkKNNRKKVSCIHKANVLRvTDGLFLEIFNEIKKKYknFNIEADDYLVDATAMYLIKNPEMFD 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLsATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:NF040619  224 VIVTTNLFGDILSDEASGLIGGLGLAPSANI-GDKKGLFEPVHGSAPDIAGKGIANPIATILSAAMMLDY-LGMKEKGDL 301

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1093537106 318 IENAVKHVLDSGKRTADLTRKgetpLSTSKLVEEI 352
Cdd:NF040619  302 IREAVKKCLENGKVTPDLGGN----LKTKEVTDKI 332
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 2-356 2.12e-80

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 249.75  E-value: 2.12e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   2 EKKIALLPGDGIGKEVMDGAVEILKAIEE-HYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKwd 80
Cdd:TIGR02089   3 QYRIAAIPGDGIGKEVVAAALQVLEAAAKrHGGFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  81 KNPSHLRPEKGLLALRKELDLYANLRPVETVESLldSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNVKNGEHTVVDT 160
Cdd:TIGR02089  81 LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGV--TSPLRNCGPGDFDFVVVRENSEGEYSGVGGRIHRGTDEEVATQN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 161 LFYKRDEMERIIERAFQLAQDRKKKVTSVDKANVLESSR-MWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVI 239
Cdd:TIGR02089 159 AIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPETFDVI 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 240 VTENMFGDILSDEASMLTGSLGMLPSASLSATGLH--LYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:TIGR02089 239 VASNLFGDILSDLGAALMGSLGVAPSANINPEGKFpsMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKEAGAK 317

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1093537106 318 IENAVKHVLDSGKRTADLTRKGetplSTSKLVEEIKAAL 356
Cdd:TIGR02089 318 IMDAIERVTAAGILTPDVGGKA----TTSEVTEAVCNAL 352
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 1-352 2.31e-78

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 243.86  E-value: 2.31e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   1 MEKKIALLPGDGIGKEVMDGAVEILKAIEEHyyhrFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGS----VGG 76
Cdd:PRK08997    1 MKQTITVIPGDGIGPSIIDATLKILDKLGCD----FEYEFADAGLTALEKHGELLPQRTLDLIEKNKIALKGPlttpVGE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  77 PKWDKNpshlrpekglLALRKELDLYANLRPVEtveslldSSPLKREYVEGVDFMIVRELTGGLYFGKPSERNvKNGEhT 156
Cdd:PRK08997   77 GFTSIN----------VTLRKKFDLYANVRPVL-------SFPGTKARYDNIDIITVRENTEGMYSGEGQTVS-EDGE-T 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 157 VVDTLFYKRDEMERIIERAFQLA-QDRKKKVTSVDKANVLES-SRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPK 234
Cdd:PRK08997  138 AEATSIITRKGAERIVRFAYELArKEGRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPE 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 235 QFDVIVTENMFGDILSDEASMLTGSLGMLPSASLsATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEE 314
Cdd:PRK08997  218 QFDVIVTTNLFGDILSDLCAGLVGGLGMAPGANI-GRDAAIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDK 295

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1093537106 315 AEAIENAVKHVLDSGKR-TADLTRKGETPLSTSKLVEEI 352
Cdd:PRK08997  296 AERIRKAIVAVIEAGDRtTRDLGGTHGTTDFTQAVIDRL 334
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 4-356 1.21e-77

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 242.52  E-value: 1.21e-77
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEEHyyhRFHFQYGM--IGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPkwDK 81
Cdd:PRK03437    6 KLAVIPGDGIGPEVVAEALKVLDAVAAG---GPGVETTEydLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDP--SV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  82 NPSHLrpEKG-LLALRKELDLYANLRPV---ETVESlldssPLKREyvEGVDFMIVRELTGGLYFGkpsernvkNG---- 153
Cdd:PRK03437   81 PSGVL--ERGlLLKLRFALDHYVNLRPSklyPGVTS-----PLAGP--GDIDFVVVREGTEGPYTG--------NGgalr 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 154 ---EHTV-----VDTLFykrdEMERIIERAFQLAQDRK-KKVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVD 223
Cdd:PRK03437  144 vgtPHEVatevsVNTAF----GVERVVRDAFERAQKRPrKHLTLVHKTNVLTfAGDLWQRTVDEVAAEYPDVTVDYQHVD 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 224 HAAMALIHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLH--LYEPVHGSAPDIAGEDKANPVAMILST 301
Cdd:PRK03437  220 AATIFMVTDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSV 299

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 302 AMMLRHSFKMeeeaeaienavkhvlDSGKR-----TADLTRKGETPLSTSKLVEEIKAAL 356
Cdd:PRK03437  300 ALLLDHLGEE---------------DAAARieaavEADLAERGKMGRSTAEVGDRIAARL 344
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 4-354 9.74e-73

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 229.99  E-value: 9.74e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKAIEE-HYYHRFHFQYGMIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPKWdkN 82
Cdd:PRK08194    5 KIAVIPGDGVGKEVVPAAVRVLKAVAEvHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPKL--V 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  83 PSHLRPEKGLLALRKELDLYANLRPVETVESLldSSPLKREyvEGVDFMIVRELTGGLYfgkpSERN--VKNGEHTVV-- 158
Cdd:PRK08194   83 PDHISLWGLLIKIRREFEQVINIRPAKQLRGI--KSPLANP--KDFDLLVVRENSEGEY----SEVGgrIHRGEDEIAiq 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 159 DTLFYKRDeMERIIERAFQLAQDRKKKVTSVDKAN-VLESSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:PRK08194  155 NAVFTRKG-TERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEFD 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLH--LYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEA 315
Cdd:PRK08194  234 VIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKYpsMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEELG 312

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1093537106 316 EAIENAVKHVLDSGKRTADLTRKGETPLSTSKLVEEIKA 354
Cdd:PRK08194  313 SHLLDVIEDVTEDGIKTPDIGGRATTDEVTDEIISRLKK 351
mito_nad_idh TIGR00175
isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent ...
 4-352 3.01e-64

isocitrate dehydrogenase, NAD-dependent, mitochondrial type; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. Mitochondrial NAD-dependent isocitrate dehydrogenases (IDH) resemble prokaryotic NADP-dependent IDH and 3-isopropylmalate dehydrogenase (an NAD-dependent enzyme) more closely than they resemble eukaryotic NADP-dependent IDH. The mitochondrial NAD-dependent isocitrate dehydrogenase is believed to be an alpha(2)-beta-gamma heterotetramer. All subunits are homologous and found by this model. The NADP-dependent IDH of Thermus aquaticus thermophilus strain HB8 resembles these NAD-dependent IDH, except for the residues involved in cofactor specificity, much more closely than it resembles other prokaryotic NADP-dependent IDH, including that of Thermus aquaticus strain YT1. [Energy metabolism, TCA cycle]


Pssm-ID: 272942  Cd Length: 333  Bit Score: 207.62  E-value: 3.01e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   4 KIALLPGDGIGKEVMDGAVEILKA------IEEHYYHRFhfqygmiggaaiDEMNSPLPQETLQMCRESDAVLLGSVggp 77
Cdd:TIGR00175   5 TVTLIPGDGIGPEISGSVKKIFRAanvpieFEEIDVSPQ------------TDGKTEIPDEAVESIKRNKVALKGPL--- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  78 kwdKNPSHLRPEKGL-LALRKELDLYANLRPVETVESLldssplKREYvEGVDFMIVRELTGGLYFGKpsernvkngEHT 156
Cdd:TIGR00175  70 ---ETPIGKGGHRSLnVALRKELDLYANVVHCKSLPGF------KTRH-EDVDIVIIRENTEGEYSGL---------EHE 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 157 VVDTL-----FYKRDEMERIIERAFQLA-QDRKKKVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVDHAAMAL 229
Cdd:TIGR00175 131 SVPGVveslkVITRDKSERIARYAFEYArKNGRKKVTAVHKANIMKlADGLFLNVCREVAKEYPDITFESMIVDNTCMQL 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 230 IHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsF 309
Cdd:TIGR00175 211 VSRPSQFDVMVMPNLYGNILSNLGAGLVGGPGLVPGANIGRDYAVFEPGVRHTGPDIAGQNIANPTALILSSVMMLNH-L 289

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1093537106 310 KMEEEAEAIENAVKHVLDSGK-RTADLTRKGetplSTSKLVEEI 352
Cdd:TIGR00175 290 GLKEHADRIQKAVLSTIAEGKnRTKDLGGTA----TTSDFTEAV 329
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 7-352 1.10e-56

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 189.32  E-value: 1.10e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   7 LLPGDGIGKEVMDGAVEILKAI------EEHYyhrfhfqygmIGGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGPkWD 80
Cdd:PLN00118   46 LFPGDGIGPEIAESVKQVFTAAgvpiewEEHY----------VGTTVDPRTGSFLTWESLESVRRNKVGLKGPMATP-IG 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  81 KNPSHLRpekglLALRKELDLYANLRPVETVeslldssPLKREYVEGVDFMIVRELTGGLYFGKpsERNVKNGehtVVDT 160
Cdd:PLN00118  115 KGHRSLN-----LTLRKELGLYANVRPCYSL-------PGYKTRYDDVDLVTIRENTEGEYSGL--EHQVVRG---VVES 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 161 L-FYKRDEMERIIERAFQLAQDR-KKKVTSVDKANVLESSR-MWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFD 237
Cdd:PLN00118  178 LkIITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFD 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 238 VIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEA 317
Cdd:PLN00118  258 VLVMPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQ 336

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1093537106 318 IENAVKHVLDSGK-RTADLTRKGETPLSTSKLVEEI 352
Cdd:PLN00118  337 IHNAILNTIAEGKyRTADLGGSSTTTDFTKAICDHL 372
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-307 3.03e-51

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 177.78  E-value: 3.03e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   1 MEKKIALLPGDGIGKEVMDGAVEILKA---------IE--EHYYHRFHfqygmiggaaidemNSPLPQETLQMCRESDAV 69
Cdd:PRK09222    3 EKTPITVAYGDGIGPEIMEAVLKILEAagapleietIEigEKVYKKGW--------------TSGISPSAWESIRRTKVL 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  70 LLGSV-----GGpkwdknpshlrpEKGL-LALRKELDLYANLRPVetveslldssplkREYVEGV-------DFMIVREL 136
Cdd:PRK09222   69 LKAPIttpqgGG------------YKSLnVTLRKTLGLYANVRPC-------------VSYHPFVetkhpnlDVVIIREN 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 137 TGGLYFGKpsernvkngEH-----TVVDTLFYKRDEMERIIERAFQLAQ--DRKKkVTSVDKANVLE-SSRMWREVAEEV 208
Cdd:PRK09222  124 EEDLYAGI---------EHrqtpdVYQCLKLISRPGSEKIIRYAFEYARanGRKK-VTCLTKDNIMKlTDGLFHKVFDEI 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 209 AMKFPDVELQHMLVDHAAMALIHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLsatGLH--LYEPVHGSAPDI 286
Cdd:PRK09222  194 AKEYPDIEAEHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANI---GEEyaMFEAVHGSAPDI 270

                         330       340
                  ....*....|....*....|.
gi 1093537106 287 AGEDKANPVAMILSTAMMLRH 307
Cdd:PRK09222  271 AGKNIANPSGLLNAAVMMLVH 291
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 5-356 4.10e-43

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 153.48  E-value: 4.10e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   5 IALLPGDGIGKEVMDGAVEILKAIEEH-YYHRFHFQYGMiggaaidemnSPLPQETLQMCRESDAVLLGSVGGPKwDKNP 83
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMHAPvYFERYEVHGDM----------KKVPEEVLESIRRNKVCLKGGLATPV-GGGV 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  84 SHLRpekglLALRKELDLYANLRPVETVESLldssPLKREyveGVDFMIVRELTGGLYFGKpsERNVKNGehtVVDTL-F 162
Cdd:PLN00123  102 SSLN-----VQLRKELDLFASLVNCFNLPGL----PTRHE---NVDIVVIRENTEGEYSGL--EHEVVPG---VVESLkV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 163 YKRDEMERIIERAFQLAQ-DRKKKVTSVDKANVLE-SSRMWREVAEEVAMKFPDVELQHMLVDHAAMALIHNPKQFDVIV 240
Cdd:PLN00123  165 ITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMKlADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQFDVMV 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 241 TENMFGDILSDEASMLTGSLGMLPSASLSAtGLHLYEPVHGSA----PDIAGEDKANPVAMILSTAMMLRHsFKMEEEAE 316
Cdd:PLN00123  245 TPNLYGNLVANTAAGIAGGTGVMPGGNVGA-DHAVFEQGASAGnvgnEKLVEQKKANPVALLLSSAMMLRH-LQFPSFAD 322

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1093537106 317 AIENAVKHVLDSGK-RTADLTRKGetplSTSKLVEEIKAAL 356
Cdd:PLN00123  323 RLETAVKRVIAEGKyRTKDLGGSS----TTQEVVDAVIANL 359
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 10-356 9.30e-42

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 150.65  E-value: 9.30e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  10 GDGIGKEVMDGAVEILKAIEEHYYH---RFHFQYGMIGGAAIDEMNSPLPQETLQMCREsdavLLGSVGGP-------KW 79
Cdd:COG0538    26 GDGIGPEITRAIWKVIDAAVEKAYGgkrDIEWKEVDAGEKARDETGDWLPDETAEAIKE----YGVGIKGPlttpvggGW 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  80 dKNPShlrpekglLALRKELDLYANLRPVETVESLldSSPLKREyvEGVDFMIVRELTGGLYFG----KPSERNVKngeh 155
Cdd:COG0538   102 -RSLN--------VTIRQILDLYVCRRPVRYFKGV--PSPVKHP--EKVDIVIFRENTEDIYAGiewkAGSPEALK---- 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 156 tVVDTLfykRDEM-----------------------ERIIERAFQLAQDRKKK-VTSVDKANVL---ESsrMWREVAEEV 208
Cdd:COG0538   165 -LIFFL---EDEMgvtvirfpedsgigikpvsdegtERLVRAAIQYALDNKRKsVTLVHKGNIMkftEG--AFKDWGYEV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 209 AMK-FPD-------------------VELQHMLVDHAAMALIHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASL 268
Cdd:COG0538   239 AEEeFGDkfitegpwekykgpkpagkIVYKDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANI 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 269 SATGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHSFKMEEEAEAIENAVKhVLDSGKRTADLTR--KGETPLSTS 346
Cdd:COG0538   319 GDDGGAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRHRGWLEAADLIEKAVEK-TIESGKVTYDLARlmEGATELSTS 397

                         410
                  ....*....|
gi 1093537106 347 KLVEEIKAAL 356
Cdd:COG0538   398 EFGDAIIENL 407
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
2-352 1.54e-35

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 134.19  E-value: 1.54e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   2 EKKIAL-LPGDGIGKEVMDGAVEIL-KAIEEHYYHRFHFQYGMI--GGAAIDEMNSPLPQETLQMCRESDAVLLGSVGGP 77
Cdd:PRK06451   22 KKPIILyVEGDGIGPEITHAAMKVInKAVEKAYGSDREIKWVEVlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETP 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  78 KwdknpshlrpEKGL----LALRKELDLYANLRPVETVESLldSSPLKREyvEGVDFMIVRELTGGLYFGKP-------- 145
Cdd:PRK06451  102 I----------GKGWksinVAIRLMLDLYANIRPVKYIPGI--ESPLKNP--EKIDLIIFRENTDDLYRGIEypydseea 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 146 --------SERNVKNGEHTVVDTLFYKRDEMERIIERAFQLAQDRK-KKVTSVDKANVLESSR-MWREVAEEVAMK-FPD 214
Cdd:PRK06451  168 kkirdflrKELGVEVEDDTGIGIKLISKFKTQRIARMAIKYAIDHKrKKVTIMHKGNVMKYTEgAFREWAYEVALKeFRD 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 215 --------------------VELQHMLVDHAAMALIHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLh 274
Cdd:PRK06451  248 yvvteeevtknyngvppsgkVIINDRIADNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTGG- 326

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1093537106 275 LYEPVHGSAPDIAGEDKANPVAMILSTAMMLRHsFKMEEEAEAIENAVKHVLDSGKRTADLTR-KGETPLSTSKLVEEI 352
Cdd:PRK06451  327 MFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfMGVRALSTTEYTDEL 404
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 5-307 6.19e-33

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 127.10  E-value: 6.19e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106   5 IALLPGDGIGKEVMDGAVEILKAIEEHYYH---RFHFQYGMIGGAAIDEMNSP--LPQETLQMCRESDAVLLGS----VG 75
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAAVEKAYKgerKISWMEIYAGEKATKVYGEDvwLPEETLDLIREYRVAIKGPlttpVG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106  76 GPKWDKNpshlrpekglLALRKELDLYANLRPVETVESLldSSPLKREyvEGVDFMIVRELTGGLYFG---KPSERNVKn 152
Cdd:PRK07006  102 GGIRSLN----------VALRQELDLYVCLRPVRYFKGV--PSPVKRP--EDTDMVIFRENSEDIYAGiewKAGSAEAK- 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 153 gehTVVDTLfykRDEM-----------------------ERIIERAFQLAQDRKKK-VTSVDKANVLE----SSRMW--- 201
Cdd:PRK07006  167 ---KVIKFL---QEEMgvkkirfpetsgigikpvseegtERLVRAAIEYAIDNDRKsVTLVHKGNIMKftegAFKDWgyq 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 202 ---REVAEEVA-----MKFPDVELQHMLV--DHAAMALIHN----PKQFDVIVTENMFGDILSDEASMLTGSLGMLPSAS 267
Cdd:PRK07006  241 laeEEFGDELIdggpwDKIKNPETGKEIIvkDSIADAFLQQillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAPGAN 320

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1093537106 268 LSaTGLHLYEPVHGSAPDIAGEDKANPVAMILSTAMMLRH 307
Cdd:PRK07006  321 IN-DGHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH 359
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
233-305 1.72e-12

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 68.20  E-value: 1.72e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1093537106 233 PKQFDVIVTENMFGDILSDEASMLTGSLGMLPSASLSATGLhLYEPVHGSAPDIAGEDKANPVAMILSTAMML 305
Cdd:PRK07362  350 PQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNAA-IFEATHGTAPKHAGLDRINPGSVILSGVMML 421
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 200-356 1.25e-03

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 40.40  E-value: 1.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 200 MWREVAEEVAMKF-------PDVELQHMLVDHAAMALIHNPKQFDVIVTENMFGDILSDEASMLTGSLGMLPS----ASL 268
Cdd:PLN00096  215 MKKVFDEEFKSKFvdkgvmkSGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSnlvgVDE 294

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1093537106 269 SATGLHLYEPVHGSAPD-----IAGEDKA-NPVAMILSTAMMLRH-------SFKMEEEAEAIENAVKHVLDSGKRTADL 335
Cdd:PLN00096  295 NGTLIKEFEASHGTVTDmdearLRGEETSlNPLGMVEGLIGAMNHaadvhggKERVHPFTAKLRAVIHKLFREGRGTRDL 374

                         170       180
                  ....*....|....*....|.
gi 1093537106 336 TrkGETPLSTSKLVEEIKAAL 356
Cdd:PLN00096  375 C--GAGGLTTEQFIDAVAEEL 393
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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