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Conserved domains on  [gi|1090990739|gb|OHP28253|]
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iron ABC transporter permease [Enterococcus sp. HMSC060D07]

Protein Classification

ABC transporter permease( domain architecture ID 10790725)

ABC transporter permease is the transmembrane subunit (TM) found in a periplasmic binding protein (PBP)-dependent ATP-binding cassette (ABC) transporter involved in the import of iron and iron-containing compounds

Gene Ontology:  GO:0043190|GO:0140359|GO:0042626|GO:0016020|GO:0006826
PubMed:  25750732|24638992|18535149|17723295
TCDB:  3.A.1

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
CeuB COG4606
ABC-type enterochelin transport system, permease component [Inorganic ion transport and ...
 2-316 1.32e-138

ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism];


:

Pssm-ID: 443656  Cd Length: 318  Bit Score: 394.49  E-value: 1.32e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   2 RYGRLVALLVILSSISLFIGVSNVQLSELLQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAG 81
Cdd:COG4606     3 KLRLLILLLLVLSILSLFIGVSDVSLSDLLSLDPEALQILLISRLPRTLAILLAGASLSVAGLIMQQLTRNRFVEPTTAG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  82 TMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQFQLVQ 161
Cdd:COG4606    83 TMESAKLGILVALLLFPGASLLGKMLVAFVFALAGTLLFLAILRRIPFKDALLVPLVGLMLGGVISAITTFFAYRFDLLQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQGNFATVIRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSI 241
Cdd:COG4606   163 SLSSWLQGDFSGVLRGRYELLWLSAPLAVLAYLYADRFTIAGMGEDFATNLGLNYRRVVNLGLVIVALITAVVVVTVGSI 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1090990739 242 PFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRRYA 316
Cdd:COG4606   243 PFLGLIVPNIVSLYMGDNLRRTLPWVALLGAGFVLACDILGRLIIYPYEIPIGTVVGVVGSAIFLYLLLRRRRRA 317
 
Name Accession Description Interval E-value
CeuB COG4606
ABC-type enterochelin transport system, permease component [Inorganic ion transport and ...
 2-316 1.32e-138

ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443656  Cd Length: 318  Bit Score: 394.49  E-value: 1.32e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   2 RYGRLVALLVILSSISLFIGVSNVQLSELLQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAG 81
Cdd:COG4606     3 KLRLLILLLLVLSILSLFIGVSDVSLSDLLSLDPEALQILLISRLPRTLAILLAGASLSVAGLIMQQLTRNRFVEPTTAG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  82 TMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQFQLVQ 161
Cdd:COG4606    83 TMESAKLGILVALLLFPGASLLGKMLVAFVFALAGTLLFLAILRRIPFKDALLVPLVGLMLGGVISAITTFFAYRFDLLQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQGNFATVIRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSI 241
Cdd:COG4606   163 SLSSWLQGDFSGVLRGRYELLWLSAPLAVLAYLYADRFTIAGMGEDFATNLGLNYRRVVNLGLVIVALITAVVVVTVGSI 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1090990739 242 PFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRRYA 316
Cdd:COG4606   243 PFLGLIVPNIVSLYMGDNLRRTLPWVALLGAGFVLACDILGRLIIYPYEIPIGTVVGVVGSAIFLYLLLRRRRRA 317
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 9-311 4.50e-53

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 176.18  E-value: 4.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   9 LLVILSSISLFIGVSNVQLSELLQ-----LDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTM 83
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSallggDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  84 DSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQF--QLVQ 161
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQGNFATV-IRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGS 240
Cdd:pfam01032 161 SILFWLMGSLSGAnWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1090990739 241 IPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIR 311
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-314 3.90e-30

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 119.94  E-value: 3.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGVSNVQLSellQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTMDS 85
Cdd:PRK10577  361 LGLLLLLALVVALSFGRDAHGWN---WLSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSG 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  86 ARLGILVAMIFLPGASLIvrslTAFCFAFAGTLLFLSLTRLFLQKNQL---MLPLIGVMLGNIIGSVATFFAYQFQL-VQ 161
Cdd:PRK10577  438 AGLGVVLALFLVPGAGFG----WLLAAALLGALAALALILLLARRGGFapeRLLLTGIALSALFTALIQLLLASGDPrAA 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQG-----NFATVIRgnyeLLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLI 236
Cdd:PRK10577  514 QLLTWLSGstygvTWAQALP----LLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATA 589

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1090990739 237 MVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRR 314
Cdd:PRK10577  590 TVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRR 667
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 53-309 6.38e-30

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 114.19  E-value: 6.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  53 ILVGATSSICGLIMQHLTQNKFVSPTTAGTMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFlQKNQ 132
Cdd:cd06550     5 LLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRG-GLSP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 133 LMLPLIGVMLGNIIGSVATFFAYQFQLV-QNMTSWLQGNFATVIRGN-YELLYAVVPLLLLVWLFAYRFTIIGLGESFAV 210
Cdd:cd06550    84 SKLILIGIVLSAFFSAGVILISLLSDDSlQDLNIWLFGSILGVTWEDlLILLIILLLVLLLLLLLSRKLNLLTFDEDLAK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 211 NLGIDYQKMQFLGIGLVSLASAVMLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARvLIFPYE 290
Cdd:cd06550   164 SLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSR-TLLPSE 242

                         250
                  ....*....|....*....
gi 1090990739 291 IPVSVIVGIIGGAIFLYLL 309
Cdd:cd06550   243 LPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
CeuB COG4606
ABC-type enterochelin transport system, permease component [Inorganic ion transport and ...
 2-316 1.32e-138

ABC-type enterochelin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443656  Cd Length: 318  Bit Score: 394.49  E-value: 1.32e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   2 RYGRLVALLVILSSISLFIGVSNVQLSELLQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAG 81
Cdd:COG4606     3 KLRLLILLLLVLSILSLFIGVSDVSLSDLLSLDPEALQILLISRLPRTLAILLAGASLSVAGLIMQQLTRNRFVEPTTAG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  82 TMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQFQLVQ 161
Cdd:COG4606    83 TMESAKLGILVALLLFPGASLLGKMLVAFVFALAGTLLFLAILRRIPFKDALLVPLVGLMLGGVISAITTFFAYRFDLLQ 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQGNFATVIRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSI 241
Cdd:COG4606   163 SLSSWLQGDFSGVLRGRYELLWLSAPLAVLAYLYADRFTIAGMGEDFATNLGLNYRRVVNLGLVIVALITAVVVVTVGSI 242

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1090990739 242 PFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRRYA 316
Cdd:COG4606   243 PFLGLIVPNIVSLYMGDNLRRTLPWVALLGAGFVLACDILGRLIIYPYEIPIGTVVGVVGSAIFLYLLLRRRRRA 317
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 9-311 4.50e-53

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 176.18  E-value: 4.50e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   9 LLVILSSISLFIGVSNVQLSELLQ-----LDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTM 83
Cdd:pfam01032   1 LLLLLILLSLFIGAVKISPSDVFSallggDDSLAALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILGIS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  84 DSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQF--QLVQ 161
Cdd:pfam01032  81 SGAALGAVLAILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGASPLRLILAGIAVSALLSALTSLLLLLLnpEALQ 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQGNFATV-IRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGS 240
Cdd:pfam01032 161 SILFWLMGSLSGAnWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVAVVGP 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1090990739 241 IPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIR 311
Cdd:pfam01032 241 IGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 17-313 7.08e-46

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 157.54  E-value: 7.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  17 SLFIGVSNVQLSELLQ------LDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTMDSARLGI 90
Cdd:COG0609     1 SLSLGAVPISLSDVLRallgpdGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  91 LVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQF--QLVQNMTSWLQ 168
Cdd:COG0609    81 VLAIVLGGGLSALGLPLAAFLGALLAALLVYLLARRGGGLSPLRLVLAGVAVSALFSALTSLLLLLAdpEQLRSIVFWLM 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 169 GNFATVirgNYELLYAVVPLLLLVWLFAYRF----TIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSIPFI 244
Cdd:COG0609   161 GSLAGA---SWDDVLLLLPVLLIGLLLALLLaralNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFV 237

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1090990739 245 GVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGR 313
Cdd:COG0609   238 GLVVPHIARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-314 3.90e-30

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 119.94  E-value: 3.90e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGVSNVQLSellQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTMDS 85
Cdd:PRK10577  361 LGLLLLLALVVALSFGRDAHGWN---WLSGQLLDALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSG 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  86 ARLGILVAMIFLPGASLIvrslTAFCFAFAGTLLFLSLTRLFLQKNQL---MLPLIGVMLGNIIGSVATFFAYQFQL-VQ 161
Cdd:PRK10577  438 AGLGVVLALFLVPGAGFG----WLLAAALLGALAALALILLLARRGGFapeRLLLTGIALSALFTALIQLLLASGDPrAA 513

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTSWLQG-----NFATVIRgnyeLLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLI 236
Cdd:PRK10577  514 QLLTWLSGstygvTWAQALP----LLIVAVLLLALALLLRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATA 589

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1090990739 237 MVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRR 314
Cdd:PRK10577  590 TVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALLMVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSRR 667
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 53-309 6.38e-30

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 114.19  E-value: 6.38e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  53 ILVGATSSICGLIMQHLTQNKFVSPTTAGTMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLFlQKNQ 132
Cdd:cd06550     5 LLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSNYALGAFAFAGALAIALLVLLLASRG-GLSP 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 133 LMLPLIGVMLGNIIGSVATFFAYQFQLV-QNMTSWLQGNFATVIRGN-YELLYAVVPLLLLVWLFAYRFTIIGLGESFAV 210
Cdd:cd06550    84 SKLILIGIVLSAFFSAGVILISLLSDDSlQDLNIWLFGSILGVTWEDlLILLIILLLVLLLLLLLSRKLNLLTFDEDLAK 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 211 NLGIDYQKMQFLGIGLVSLASAVMLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARvLIFPYE 290
Cdd:cd06550   164 SLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSR-TLLPSE 242

                         250
                  ....*....|....*....
gi 1090990739 291 IPVSVIVGIIGGAIFLYLL 309
Cdd:cd06550   243 LPVGPVTALLGAPYFLYLL 261
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
6-313 1.53e-28

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 112.06  E-value: 1.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGVSNVQLSELL---QLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGT 82
Cdd:PRK09777    9 ITLALAGCALLSLRMGVIPLPWRALLtdwQAGDEHYYVLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDILGV 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  83 MDSARLGILVAMIFLPGASLIVRSLtafcFAFAGTLLFLSLTRLFLQKNQLM-LPLIGVMLGNIIGSVATFFAY-QFQLV 160
Cdd:PRK09777   89 NHAASLASVGALLLFPSLPVMWLPL----LAFIGGMAGLILLKMLAGTHQPMkLALTGVALSALWASLTDYLMLsRPQDI 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 161 QNMTSWLQG-------NFATVIrgnyelLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAV 233
Cdd:PRK09777  165 NNALLWLTGslwgrdwSFVKVA------LPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTAT 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 234 MLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGR 313
Cdd:PRK09777  239 GVAACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVRMR 318
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 6-314 3.57e-28

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 111.20  E-value: 3.57e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGvsNVQLSELLQLDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTMDS 85
Cdd:PRK03784   21 LSVLLLLALLLSLCAG--EQWISPGDWLSPRGELFVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  86 ARLGILVAMIFLPGA-SLIVRSLTAFCFAFAGTLLFLSLTRLFLQKNQLMLpLIGVMLGNIIGSVAT---FFAYQFQLVQ 161
Cdd:PRK03784   99 AGVALVAAVLLGQGLlPPWALSLCAIAGALLITLILLRFARRHRLSTSRLL-LAGVALGIICSALMTwavYFSTSLDLRQ 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 162 NMTsWLQGNFATVIRGNYELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSI 241
Cdd:PRK03784  178 LMY-WMMGGFGGVDWRQSWLMLALLPVLIWLCCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAI 256

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1090990739 242 PFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGRR 314
Cdd:PRK03784  257 GFIGLVIPHILRLCGLTDHRVLLPGCALAGASLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRSHR 329
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
6-314 5.45e-22

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 96.45  E-value: 5.45e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGVSNVQLSELLQL----DGQSLQILLV--TRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTT 79
Cdd:PRK10577   17 LALLLLLALALTLTQLSAALPLSQWLQAlwgpDADDLEQLLLhySRLPRLAIALLVGAALGLAGALLQQVLRNPLASPTT 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  80 AGTMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLLFLSLTRLflqKNQLMLPLI--GVMLGNIIGSVAT-FFAYQ 156
Cdd:PRK10577   97 LGVAAGAQLALVLATLFAPALLALASQLAAFAGGLLAAALVFALAGG---KRLSPLRLVlaGMVVSLYLGALTTlLLLFN 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 157 FQLVQNMTSW-----LQGNFATVIRgnyeLLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLAS 231
Cdd:PRK10577  174 EQYLQGLFLWgagslAQNDWSGVQR----LLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRLAALALAVLLS 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 232 AVMLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPY--EIPVSVIVGIIGGAIFLYLL 309
Cdd:PRK10577  250 AAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTALIGAPLLLWLL 329


                  ....*
gi 1090990739 310 IRGRR 314
Cdd:PRK10577  330 PRLRS 334
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
2-314 1.34e-18

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 84.75  E-value: 1.34e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   2 RYGRLVALLVILSSISLF----IGVSNVQ-LSELLQLDGQSLQILLVT--RLPRTICLILVGATSSICGLIMQHLTQNKF 74
Cdd:PRK11228    1 LWGLPVAALIGLFWLSLFcysaIPISAADaLNALLPGHTPTLPEALVQnlRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  75 VSPTTAGTMDSARLGILVAMIF----LPGASLivrSLTAFCFAFAGTLLFLSLTRLFLQ---KNQLMLPLIGVMLGNIIG 147
Cdd:PRK11228   81 ASPSLLGINSGAALAMALTSALsptpFAGYSL---AFIAACGGGLSWLLVMTAGGGWRHthdRNRLILAGIALSALCMAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 148 SVATFFAYQFQlVQNMTSWLQGNFATVIRGNYELLY-AVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGL 226
Cdd:PRK11228  158 TRITLLLAEDH-AYGIFYWLAGGVSHARWQEVWQLLpFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNML 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 227 VSLASAVMLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFL 306
Cdd:PRK11228  237 VLLLVGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFV 316


                  ....*...
gi 1090990739 307 yLLIRGRR 314
Cdd:PRK11228  317 -WLARRRG 323
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
6-314 3.59e-17

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 80.52  E-value: 3.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIGVSNVQLSELLQ-----LDGQSLQILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTA 80
Cdd:PRK10441   16 LLLLLIIATALSLLIGAKSLPASVVLEalsgtCQSADCTIVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  81 GTMDSARLGILVAMIFLPGASLIVRSLTAFCFAFAGTLL-FLSLTRLFLQKNQLMLPLIGVMLGNIIGSVATFFAYQFQL 159
Cdd:PRK10441   96 GVNAGASFAIVLGAALFGYSSAQEQLAMAFAGALVASLIvAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPD 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 160 VQN-MTSWLQGNFATVIRGNYELLYAVVPLLLLVWLFAYR-FTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIM 237
Cdd:PRK10441  176 VYDqLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLLSRaLNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAV 255

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1090990739 238 VGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGSLFLVFCDLVARVLIfPYEIPVSVIVGIIGGAIFLYLLIRGRR 314
Cdd:PRK10441  256 VGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALLLFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKTR 331
btuC PRK09535
cobalamin ABC transporter permease BtuC;
39-311 2.70e-16

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 78.64  E-value: 2.70e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  39 QILLVTRLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTAGTMDSARLGIlVAMIFLPgaSLIVRSLTAFcfAFAGTL 118
Cdd:PRK09535   89 TIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVGA-VAAIVLP--LAVPFGLQAA--AFAGAL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 119 LFLSLTRLFLQKNQ----LMLPLIGVMLGNIIGSVATFFAYQF-QLVQNMTSWLQGNFATVIRGNYELLY-AVVPLLLLV 192
Cdd:PRK09535  164 VAAFGVYAIATENGrtpvATLLLAGVAVQTFLGAVISYLLLHSgESLRRAVYWLMGHLHGSTWSDVEVALpVVVVGFVVL 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 193 WLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAVMLIMVGSIPFIGVIIPNLVSRIYGDQVHKTIGVTALAGS 272
Cdd:PRK09535  244 LAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSALAGA 323

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1090990739 273 LFLVFCDLVARVliFPYEIPVSVIVGIIGGAIFLYLLIR 311
Cdd:PRK09535  324 SFLVATDTVARS--GPAEVPVGIVTAALGAPFFLYLLRT 360
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
6-314 3.32e-12

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 66.27  E-value: 3.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739   6 LVALLVILSSISLFIG---VSNVQLSELLQLDGQSLQILLVT--RLPRTICLILVGATSSICGLIMQHLTQNKFVSPTTA 80
Cdd:PRK10440   15 LLAACVAAGLWGLRSGavtLETSQVFAALMGDAPRSMTMVVTewRLPRVLMALLIGAALGVSGAIFQSLMRNPLGSPDVM 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739  81 GTMDSARLGILVAMIflpgasLIVRSLTAFCF-AFAGTLLFLSLTRLFLQKN---QLMLPLIGVMLGNIIGSVATFFAYQ 156
Cdd:PRK10440   95 GFNTGAWSGVLVAMV------LFGQDLTAIALaAMAGGIVTSLLVWLLAWRNgidTFRLIIIGIGVRAMLVAFNTWLLLK 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 157 FQLVQNMTS--WLQGNFATVIRGN-YELLYAVVPLLLLVWLFAYRFTIIGLGESFAVNLGIDYQKMQFLGIGLVSLASAV 233
Cdd:PRK10440  169 ASLETALTAglWNAGSLNGLTWAKtSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVERSRLLLMLVAVVLTAA 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090990739 234 MLIMVGSIPFIGVIIPNLVSRIYGDQvHKTIGVTALAGSLFLVFCDLVARVLIFPYEIPVSVIVGIIGGAIFLYLLIRGR 313
Cdd:PRK10440  249 ATALAGPISFIALVAPHIARRLSGTA-RWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTVSLGGIYLIVLLIQES 327


                  .
gi 1090990739 314 R 314
Cdd:PRK10440  328 R 328
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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