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Conserved domains on  [gi|1090864036|ref|NP_001333613|]
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solute carrier family 13 member 2 isoform e [Homo sapiens]

Protein Classification

transporter permease( domain architecture ID 229430)

transporter permease similar to ArsB/NhaD family permeases, which typically contain 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsB_NhaD_permease super family cl21473
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 5-494 3.28e-118

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


The actual alignment was detected with superfamily member pfam00939:

Pssm-ID: 473875 [Multi-domain]  Cd Length: 472  Bit Score: 356.30  E-value: 3.28e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   5 GNVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAV 84
Cdd:pfam00939  75 SWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  85 LDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqalpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIA 164
Cdd:pfam00939 153 IMSLPPA----------FGSDPEKGSER--------------------------------RIGAYLMWTVYQSTSITSAM 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 165 TLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVI 244
Cdd:pfam00939 191 FLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 245 QTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgnlaFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdp 324
Cdd:pfam00939 256 KTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SLN------IDATTVAIIGLALMLL------------ 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 325 enpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTE 401
Cdd:pfam00939 307 ---------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYL 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 402 CTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLI 479
Cdd:pfam00939 378 FASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLI 457

                         490
                  ....*....|....*
gi 1090864036 480 IALAINSWGIPLFSL 494
Cdd:pfam00939 458 LLLLGNWWWKPLGSL 472
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 5-494 3.28e-118

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 356.30  E-value: 3.28e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   5 GNVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAV 84
Cdd:pfam00939  75 SWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  85 LDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqalpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIA 164
Cdd:pfam00939 153 IMSLPPA----------FGSDPEKGSER--------------------------------RIGAYLMWTVYQSTSITSAM 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 165 TLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVI 244
Cdd:pfam00939 191 FLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 245 QTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgnlaFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdp 324
Cdd:pfam00939 256 KTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SLN------IDATTVAIIGLALMLL------------ 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 325 enpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTE 401
Cdd:pfam00939 307 ---------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYL 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 402 CTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLI 479
Cdd:pfam00939 378 FASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLI 457

                         490
                  ....*....|....*
gi 1090864036 480 IALAINSWGIPLFSL 494
Cdd:pfam00939 458 LLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 7-488 1.60e-79

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 253.66  E-value: 1.60e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   7 VAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLD 86
Cdd:cd01115    40 AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  87 QLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSASIGGIATL 166
Cdd:cd01115   120 KLDISP-------------------------------------------------------SRLLMPLAFAASIGGMLTL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 167 TGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVIllllawlwlqilflgfnfrknfgigekmqeqqqaaycviqt 246
Cdd:cd01115   145 IGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLII----------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 247 ehrllgpmtfaekaisilfVILVLLWFTREPGFFLGWGNLAFPNA-KGESMVSDGTVAIFIGIIMFiipskfpgltqdpe 325
Cdd:cd01115   181 -------------------GLLYLWFIFRLAVLIITIVLLAALAAiTGLLPVSVAIAIGAIVLVFG-------------- 227

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 326 npgklkaplGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTS 404
Cdd:cd01115   228 ---------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFIS 298

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 405 NVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:cd01115   299 NTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMI 378


                  ....
gi 1090864036 485 NSWG 488
Cdd:cd01115   379 PLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
20-487 2.19e-78

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 250.07  E-value: 2.19e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  20 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 99
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 100 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 179
Cdd:COG0471    74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 180 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 259
Cdd:COG0471   111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 260 AISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIIMFIipskfpgltqdpenpgklkapLGLLDW 339
Cdd:COG0471   176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLL---------------------TGVLTW 217

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 340 KTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILAS 418
Cdd:COG0471   218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1090864036 419 MAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 487
Cdd:COG0471   298 LAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 8-487 2.12e-43

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 159.82  E-value: 2.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   8 AVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWISNTA-TSAMMVPIAHAV 84
Cdd:TIGR00785  57 ALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  85 LDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltqcMSLCVCYSASIGGIA 164
Cdd:TIGR00785 137 LPLLGSK-----------------------------------PEKSPRKIGKY------------LMLGIAYSASIGSSG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 165 TLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGfnfrknfgigEKMQEQQQAAycVI 244
Cdd:TIGR00785 170 FLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPP----------ELKLKDEVDL--WA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 245 QTEHRLLGPMTFAEKAISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIimfiipskfpgltqdp 324
Cdd:TIGR00785 235 KEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG--------------INASVVALLAVV---------------- 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 325 enpgkLKAPLGLLDWKTVNQ-KMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TE 401
Cdd:TIGR00785 282 -----LMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYF 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 402 CTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLII 480
Cdd:TIGR00785 357 FASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVL 436


                  ....*..
gi 1090864036 481 ALAINSW 487
Cdd:TIGR00785 437 LLVGTLW 443
 
Name Accession Description Interval E-value
Na_sulph_symp pfam00939
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ...
 5-494 3.28e-118

Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.


Pssm-ID: 279307 [Multi-domain]  Cd Length: 472  Bit Score: 356.30  E-value: 3.28e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   5 GNVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPapLILGFMLVTAFLSMWISNTATSAMMVPIAHAV 84
Cdd:pfam00939  75 SWALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPI 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  85 LDQLHSSqassnveegsNNPTFELQEPSpqkevtkldngqalpvtsassegrahlsqkhlHLTQCMSLCVCYSASIGGIA 164
Cdd:pfam00939 153 IMSLPPA----------FGSDPEKGSER--------------------------------RIGAYLMWTVYQSTSITSAM 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 165 TLTGTAPNLVLQGQINSlfpQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNfgigekmqeqqqAAYCVI 244
Cdd:pfam00939 191 FLTAMAPNLLLLGLMNS---ILGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 245 QTEHRLLGPMTFAEKAISILFVILVLLWFTREpgfflgwgnlaFPNakgesmVSDGTVAIFIGIIMFIipskfpgltqdp 324
Cdd:pfam00939 256 KTELKELGPMTFREKALLGLFVLLLLLWIFGG-----------SLN------IDATTVAIIGLALMLL------------ 306

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 325 enpgklkapLGLLDWK-TVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQS--VPAPAIAIILSLLVATFTE 401
Cdd:pfam00939 307 ---------LRILDWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSLSgfSPAMAFIIILSLFYLSHYL 377

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 402 CTSNVATTTIFLPILASMAQAICLHP-LYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLI 479
Cdd:pfam00939 378 FASATAHTAAMLPIFAAVAQAIPGAPpLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLI 457

                         490
                  ....*....|....*
gi 1090864036 480 IALAINSWGIPLFSL 494
Cdd:pfam00939 458 LLLLGNWWWKPLGSL 472
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 7-488 1.60e-79

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 253.66  E-value: 1.60e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   7 VAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLD 86
Cdd:cd01115    40 AFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  87 QLHSSQassnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhltQCMSLCVCYSASIGGIATL 166
Cdd:cd01115   120 KLDISP-------------------------------------------------------SRLLMPLAFAASIGGMLTL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 167 TGTAPNLVLQGQINSLFPQNGNvvnFASWFSFAFPTMVIllllawlwlqilflgfnfrknfgigekmqeqqqaaycviqt 246
Cdd:cd01115   145 IGTPPNLVASGYLESLGGQGFS---FFEFTPIGLPLLII----------------------------------------- 180

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 247 ehrllgpmtfaekaisilfVILVLLWFTREPGFFLGWGNLAFPNA-KGESMVSDGTVAIFIGIIMFiipskfpgltqdpe 325
Cdd:cd01115   181 -------------------GLLYLWFIFRLAVLIITIVLLAALAAiTGLLPVSVAIAIGAIVLVFG-------------- 227

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 326 npgklkaplGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTS 404
Cdd:cd01115   228 ---------GVLLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFIS 298

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 405 NVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:cd01115   299 NTATAVLLAPIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMI 378


                  ....
gi 1090864036 485 NSWG 488
Cdd:cd01115   379 PLIW 382
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
20-487 2.19e-78

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 250.07  E-value: 2.19e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  20 FGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSsqassnvEE 99
Cdd:COG0471     1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALGS-------EK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 100 GSNNPTFelqepspqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQGQI 179
Cdd:COG0471    74 RSKFGSA-------------------------------------------LLLPIAFAASIGGMGTLIGTPPNLIAAGLL 110

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 180 NSLFPQNgnvVNFASWFSFAFPTMVILLLLAWLwlqilFLGFNFRKNFGIGEKMQEqqqaaycVIQTEHRLLGPMTFAEK 259
Cdd:COG0471   111 EEATGIP---ISFFEWMLVGLPVALVGLLLLWL-----VLYRLLPPEIKEVPGSKE-------VIREELAELGPLSRREK 175

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 260 AISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIIMFIipskfpgltqdpenpgklkapLGLLDW 339
Cdd:COG0471   176 IALAIFALTVLLWIT---GSLHG--------------IPIAVVALLGAVLLLL---------------------TGVLTW 217

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 340 KTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTP-LQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILAS 418
Cdd:COG0471   218 KDAYKSIPWGVLLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAIS 297

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1090864036 419 MAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSW 487
Cdd:COG0471   298 LAQALGVNPLPLALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
dass TIGR00785
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ...
 8-487 2.12e-43

anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273267 [Multi-domain]  Cd Length: 444  Bit Score: 159.82  E-value: 2.12e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036   8 AVEYLKDSNL-LFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPL-ILGFMLVTAFLSMWISNTA-TSAMMVPIAHAV 84
Cdd:TIGR00785  57 ALSGFADPTIwLFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSL 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  85 LDQLHSSqassnveegsnnptfelqepspqkevtkldngqalPVTSASSEGRAhlsqkhlhltqcMSLCVCYSASIGGIA 164
Cdd:TIGR00785 137 LPLLGSK-----------------------------------PEKSPRKIGKY------------LMLGIAYSASIGSSG 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 165 TLTGTAPNLVLQGqinSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGfnfrknfgigEKMQEQQQAAycVI 244
Cdd:TIGR00785 170 FLTGSAPNALAAG---ILSKILGIQISWGDWFLAGLPLGIILLLLVPLLLYVLFPP----------ELKLKDEVDL--WA 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 245 QTEHRLLGPMTFAEKAISILFVILVLLWFTrepGFFLGwgnlafpnakgesmVSDGTVAIFIGIimfiipskfpgltqdp 324
Cdd:TIGR00785 235 KEELEEMGPMSFREKALLGIFLLALLLWIF---GGSLG--------------INASVVALLAVV---------------- 281

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 325 enpgkLKAPLGLLDWKTVNQ-KMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATF--TE 401
Cdd:TIGR00785 282 -----LMLFLGIVTWKDIQKnKVAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGILDGLSPTIAVLVLVVLFYIilYF 356

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 402 CTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLII 480
Cdd:TIGR00785 357 FASNTAHTAALVPIFFSVASAQGIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLIVL 436


                  ....*..
gi 1090864036 481 ALAINSW 487
Cdd:TIGR00785 437 LLVGTLW 443
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 14-484 2.93e-36

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 138.92  E-value: 2.93e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  14 DSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIvGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQa 93
Cdd:cd00625    40 ETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  94 ssnveegsnnptfelqepspqkevtkldngqalpvtsassegrahlsqkhlhlTQCMSLCVCYSASIGGIATLTGTAPNL 173
Cdd:cd00625   118 -----------------------------------------------------PVPLLLALAFAANIGGAATPIGNPPNL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 174 VLQGQINslfpqngnvVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYcviqtehrllgp 253
Cdd:cd00625   145 IIASLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAEPLPARP------------ 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 254 mTFAEKAISILFVILVLLWFtrepGFFLGWGNLafpnakgesMVSDGTVAIFIGIIMFiipskfpgltqdpenpgklkap 333
Cdd:cd00625   204 -LLKKFLLLALLLLLLFVLL----FFFLIPLGL---------IALLGALLLLLLLVRG---------------------- 247

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 334 lglLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFL 413
Cdd:cd00625   248 ---LDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLL 324

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1090864036 414 PILASM-----AQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVfsfgDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:cd00625   325 PIAASLappepAWLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
CitMHS pfam03600
Citrate transporter;
17-432 5.43e-22

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 97.00  E-value: 5.43e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  17 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSqassn 96
Cdd:pfam03600  43 LLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIVLALARRLGLP----- 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036  97 veegsnnptfelqePSPqkevtkldngqalpvtsassegrahlsqkhlhltqcMSLCVCYSASIGGIATLTGTAPNLVLQ 176
Cdd:pfam03600 118 --------------PSP------------------------------------LLIALAFAANIGGTATPIGDPPNIIIA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 177 GQINSLFPQNGNVVNFASWFSFAFPTMVillllawlwlqilFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGpmtf 256
Cdd:pfam03600 148 SALGLSFGDFGFFMFPPVGVALLLVGLL-------------PLLLIFRKLLPVRKEEEAELEELRKRAIKDKLLLA---- 210

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 257 aekaisILFVILVLLWFTREPGFFLGWGNLAfpnakgesmvsdgtvaifigiimfiipskfpgltqdpenpgkLKAPLGL 336
Cdd:pfam03600 211 ------ISALVLALVILGFLLLSVLALAGAL------------------------------------------LLLLTGV 242

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 337 LDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLqsVPAPAIAIILSLLVATFTECTSNVATTTIFLPIL 416
Cdd:pfam03600 243 LDPEEALKAVDWSTLLFFAGLFILVGALEKTGLADALADALGGL--SGLLVALALILWLSALLSAFISNVPTAALMAPII 320

                         410
                  ....*....|....*.
gi 1090864036 417 ASMAQAICLHPLYVML 432
Cdd:pfam03600 321 VGMAPAAGLGDPDPLA 336
CitMHS pfam03600
Citrate transporter;
333-484 8.30e-11

Citrate transporter;


Pssm-ID: 460985 [Multi-domain]  Cd Length: 342  Bit Score: 63.49  E-value: 8.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 333 PLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIF 412
Cdd:pfam03600  24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1090864036 413 LPILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
ArsB_NhaD_permease cd00625
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ...
 334-484 8.77e-11

Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.


Pssm-ID: 238344 [Multi-domain]  Cd Length: 396  Bit Score: 63.81  E-value: 8.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 334 LGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLqSVPAPAIAIILSLLVATFTECTSNVATTTIFL 413
Cdd:cd00625    25 LGVVSPKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAKLARA-SKGSRRLLLLLMLLTAALSAFFSNDATAVLLT 103

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1090864036 414 PILASMAQAICL-HPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:cd00625   104 PIVLALLRKLGLsPPVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLGLL 176
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
334-484 5.27e-08

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 55.13  E-value: 5.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 334 LGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFL 413
Cdd:COG1055    39 LGVVSLEDALEAIDWNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLT 118

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1090864036 414 PILASMAQAICLHPLYVMLPCTLATSLA-FMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAI 484
Cdd:COG1055   119 PVVLAIARRLGLNPVPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLLVL 190
SLC13_permease cd01115
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ...
 349-491 8.03e-08

Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.


Pssm-ID: 238535 [Multi-domain]  Cd Length: 382  Bit Score: 54.51  E-value: 8.03e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 349 NIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPL 428
Cdd:cd01115    47 PAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALGLAAKLDISPS 126

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 429 YVMLPCTLATSLAFML-PVATPPNAIV------FSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPL 491
Cdd:cd01115   127 RLLMPLAFAASIGGMLtLIGTPPNLVAsgylesLGGQGFSFFEFTPIGLPLLIIGLLYLWFIFRLAVLII 196
CitT COG0471
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
17-89 2.96e-04

Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];


Pssm-ID: 440239 [Multi-domain]  Cd Length: 369  Bit Score: 43.22  E-value: 2.96e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1090864036  17 LLFFGGLL-VAIAVEHWNLHKRIALRVL-LIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLH 89
Cdd:COG0471   229 LLLFGGGLaLGAALEKTGLAAWLADALLpLLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALG 303
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
344-484 3.53e-04

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 42.81  E-value: 3.53e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 344 QKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAI 423
Cdd:COG1055   266 KKVDWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATG 345

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1090864036 424 CLHPLY--VMLPCTLATSLafmLPVATPPNAIV----------FSFGDLkvldmARAGFLLNIIGVLIIALAI 484
Cdd:COG1055   346 NPEPLWlaLALGATLGGNL---TPIGSAANVIVlgiaekkgikISFGEF-----LKVGLPLTLLTLLIALLYL 410
ArsB COG1055
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
17-88 3.34e-03

Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];


Pssm-ID: 440675 [Multi-domain]  Cd Length: 415  Bit Score: 39.73  E-value: 3.34e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1090864036  17 LLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQL 88
Cdd:COG1055    57 LFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRL 128
P_permease cd01116
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ...
 335-484 5.57e-03

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.


Pssm-ID: 238536 [Multi-domain]  Cd Length: 413  Bit Score: 39.16  E-value: 5.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1090864036 335 GLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLP 414
Cdd:cd01116    34 LSPDLETIVSWVDWETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVP 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1090864036 415 ILASMAQAICLHPLYVMLPCTLATSLAFML-PVATPPNAIVFSFGDLKVLDmaragFLLNIIGVLIIALAI 484
Cdd:cd01116   114 VTIRLCEVLGLNPVPVLISEVIAANIGGAAtLIGDPPNIMIGSAAGLTFND-----FLLHMLPSVVLALVV 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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