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Conserved domains on  [gi|1088625765|gb|OHE40044|]
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MAG: hypothetical protein A2013_02285 [Tenericutes bacterium GWE2_38_8]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1312 super family cl02206
N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; ...
 81-151 2.27e-06

N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Domains of Unknown Function 1312 (DUF1312) are represented in at least 71 bacterial species with no functional annotation. Included in this family are N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431, having similar structure and surface features that appear to be conserved across these domain families, suggesting similar function. NusG contains NGN at the N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at the C-terminus in bacteria and archaea, and this insert (often known as Domain II) is found in several bacteria. Lin0431 is similar to NGN-insert but does ot contain the disulphite bridge


The actual alignment was detected with superfamily member cd09846:

Pssm-ID: 470492  Cd Length: 81  Bit Score: 43.39  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088625765  81 VINEGQQTITLLGD-----YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSRegesTGW------PLICLPNRIRVEF 149
Cdd:cd09846     6 VDGKVVRRIDLDGVgkpytFSIEGEGYTNIIEVEDGR--VRVKESDCPDKICVK----TGWiskpgqTIVCLPNRVIIKI 79


                  ..
gi 1088625765 150 ET 151
Cdd:cd09846    80 EG 81
 
Name Accession Description Interval E-value
DUF1312 cd09846
N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; ...
 81-151 2.27e-06

N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Domains of Unknown Function 1312 (DUF1312) are represented in at least 71 bacterial species with no functional annotation. Included in this family are N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431, having similar structure and surface features that appear to be conserved across these domain families, suggesting similar function. NusG contains NGN at the N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at the C-terminus in bacteria and archaea, and this insert (often known as Domain II) is found in several bacteria. Lin0431 is similar to NGN-insert but does ot contain the disulphite bridge


Pssm-ID: 197363  Cd Length: 81  Bit Score: 43.39  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088625765  81 VINEGQQTITLLGD-----YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSRegesTGW------PLICLPNRIRVEF 149
Cdd:cd09846     6 VDGKVVRRIDLDGVgkpytFSIEGEGYTNIIEVEDGR--VRVKESDCPDKICVK----TGWiskpgqTIVCLPNRVIIKI 79


                  ..
gi 1088625765 150 ET 151
Cdd:cd09846    80 EG 81
COG5341 COG5341
Uncharacterized conserved protein [Function unknown];
95-155 1.06e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 444125  Cd Length: 126  Bit Score: 39.85  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1088625765  95 YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSREG--ESTGWPLICLPNRIRVEFETNDED 155
Cdd:COG5341    59 IEVPGPLGTNIIEIKDGR--VRVKEADCPDQICVKTGwiSRPGETIVCLPNKVVIEIEGEDED 119
NusG_II pfam07009
NusG domain II; This domain is found in some NusG proteins where it forms domain II. However ...
 83-153 6.66e-04

NusG domain II; This domain is found in some NusG proteins where it forms domain II. However most NusG proteins are missing this domain. In other cases this domain is found in isolation. The function of this domain is unknown.


Pssm-ID: 462066  Cd Length: 107  Bit Score: 37.12  E-value: 6.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088625765  83 NEGQQTITLLGDYEINgerqIVVIRydygRKSVEIIQEQSPNNICSRegesTGW------PLICLPNRIRVEFETND 153
Cdd:pfam07009  43 VDEDYTIEIKGEGGYN----TIEIK----DGKVRVTEADCPDQICVK----TGWiskpgqTIVCLPNKVVIEIEGSE 107
 
Name Accession Description Interval E-value
DUF1312 cd09846
N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; ...
 81-151 2.27e-06

N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Domains of Unknown Function 1312 (DUF1312) are represented in at least 71 bacterial species with no functional annotation. Included in this family are N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431, having similar structure and surface features that appear to be conserved across these domain families, suggesting similar function. NusG contains NGN at the N-terminus and Kyrpides Ouzounis and Woese (KOW) repeats at the C-terminus in bacteria and archaea, and this insert (often known as Domain II) is found in several bacteria. Lin0431 is similar to NGN-insert but does ot contain the disulphite bridge


Pssm-ID: 197363  Cd Length: 81  Bit Score: 43.39  E-value: 2.27e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1088625765  81 VINEGQQTITLLGD-----YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSRegesTGW------PLICLPNRIRVEF 149
Cdd:cd09846     6 VDGKVVRRIDLDGVgkpytFSIEGEGYTNIIEVEDGR--VRVKESDCPDKICVK----TGWiskpgqTIVCLPNRVIIKI 79


                  ..
gi 1088625765 150 ET 151
Cdd:cd09846    80 EG 81
COG5341 COG5341
Uncharacterized conserved protein [Function unknown];
95-155 1.06e-04

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 444125  Cd Length: 126  Bit Score: 39.85  E-value: 1.06e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1088625765  95 YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSREG--ESTGWPLICLPNRIRVEFETNDED 155
Cdd:COG5341    59 IEVPGPLGTNIIEIKDGR--VRVKEADCPDQICVKTGwiSRPGETIVCLPNKVVIEIEGEDED 119
NGN-insert_like cd09910
NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) ...
 95-150 1.48e-04

NGN-insert domain found between N-terminal domain (D1) and C-terminal KOW domain (DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN); This family contains a unique insert (domain II, DII) found between the highly conserved N-terminal domain (NGN, domain I, D1) and C-terminal Kyrpides Ouzounis and Woese domain (KOW, domain III, DIII) repeats of some N-Utilization Substance G (NusG) N-terminal (NGN) proteins in bacteria such as Aquifex aeolicus NusG (AaeNusG). NusG was originally discovered as having an N-dependent antitermination enhancing activity in Escherichia coli, and has since been shown to have a variety of functions such as being involved in RNA polymerase elongation and Rho-termination. Orthologs of NusG gene exist in bacteria, but their functions and requirements are diverse. The function of DII is as yet unknown, and belongs to Domains of Unknown Function 1312 (DUF1312).


Pssm-ID: 197364  Cd Length: 80  Bit Score: 38.38  E-value: 1.48e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1088625765  95 YEINGERQIVVIRYDYGRksVEIIQEQSPNNICSREG--ESTGWPLICLPNRIRVEFE 150
Cdd:cd09910    23 IEVEGPLGPTTIEIKDGK--ARVVSSPCPNKYCVRQGwiSRAGQWIVCLPNQVSVEIE 78
NusG_II pfam07009
NusG domain II; This domain is found in some NusG proteins where it forms domain II. However ...
 83-153 6.66e-04

NusG domain II; This domain is found in some NusG proteins where it forms domain II. However most NusG proteins are missing this domain. In other cases this domain is found in isolation. The function of this domain is unknown.


Pssm-ID: 462066  Cd Length: 107  Bit Score: 37.12  E-value: 6.66e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1088625765  83 NEGQQTITLLGDYEINgerqIVVIRydygRKSVEIIQEQSPNNICSRegesTGW------PLICLPNRIRVEFETND 153
Cdd:pfam07009  43 VDEDYTIEIKGEGGYN----TIEIK----DGKVRVTEADCPDQICVK----TGWiskpgqTIVCLPNKVVIEIEGSE 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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