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Conserved domains on  [gi|1086084971|emb|SDU95169|]
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Nitroreductase [Pseudomonas vancouverensis]

Protein Classification

NfnB family protein( domain architecture ID 10002498)

NfnB family protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 157-319 7.85e-30

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


:

Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.48  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 157 FNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-YHQNGNAGFADTIDKLLIITG 235
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAeALAEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 236 DTRAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGHTKQnfDVAAS 315
Cdd:COG0778    81 DPDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWI----GGFDPEKVRELLGLPEGEEPVALLALGYPAE--ELNPR 154


                  ....
gi 1086084971 316 PRKP 319
Cdd:COG0778   155 PRKP 158
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 157-319 7.85e-30

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.48  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 157 FNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-YHQNGNAGFADTIDKLLIITG 235
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAeALAEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 236 DTRAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGHTKQnfDVAAS 315
Cdd:COG0778    81 DPDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWI----GGFDPEKVRELLGLPEGEEPVALLALGYPAE--ELNPR 154


                  ....
gi 1086084971 316 PRKP 319
Cdd:COG0778   155 PRKP 158
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 164-323 2.14e-27

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 104.59  E-value: 2.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEK--NTIRNILYHqngnagfADTidkLLIITGDtraft 241
Cdd:cd02136     5 RRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKarERLKKAFFG-------APV---ALFLTMD----- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 242 ENESNQIFVDGGLFSMNLILALHSAGLGSCALntsYSYLKEHS-VKKIARIPNSERLIMMLAVGHTKQNFDVA--ASPRK 318
Cdd:cd02136    70 KVLGPWSWFDLGAFLQNLMLAAHALGLGTCPQ---GALAGYPDvVRKELGIPDDEELVCGIALGYPDPDAPVNqfRTPRE 146


                  ....*
gi 1086084971 319 PKYDF 323
Cdd:cd02136   147 PLEEF 151
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 164-305 2.50e-23

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 94.38  E-value: 2.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-----------------------YHQNGN 220
Cdd:pfam00881   4 RRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAeaalelllvepaaalllllrrdaNLKLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 221 AGFADTIDKLLIITGD----TRAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSER 296
Cdd:pfam00881  84 QDFLRGAPVLIVITASlstyLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPI----GGFDAAAVRELLGLPDDER 159


                  ....*....
gi 1086084971 297 LIMMLAVGH 305
Cdd:pfam00881 160 LVGLIAVGY 168
 
Name Accession Description Interval E-value
NfnB COG0778
Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway ...
 157-319 7.85e-30

Nitroreductase [Energy production and conversion]; Nitroreductase is part of the Pathway/BioSystem: Pyrimidine degradation


Pssm-ID: 440541 [Multi-domain]  Cd Length: 163  Bit Score: 111.48  E-value: 7.85e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 157 FNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-YHQNGNAGFADTIDKLLIITG 235
Cdd:COG0778     1 LLELLLTRRSVRKFTDKPVSDEELEELLEAARLAPSAGNLQPWRFVVVRDPELRERLAeALAEANQEWVADAPVLIVVCA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 236 DTRAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGHTKQnfDVAAS 315
Cdd:COG0778    81 DPDRSEKVPERYALLDAGIAAQNLLLAARALGLGTCWI----GGFDPEKVRELLGLPEGEEPVALLALGYPAE--ELNPR 154


                  ....
gi 1086084971 316 PRKP 319
Cdd:COG0778   155 PRKP 158
PnbA_NfnB-like cd02136
nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as ...
 164-323 2.14e-27

nitroreductase similar to Mycobacterium smegmatis NfnB; Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source of reducing equivalents in an obligatory two-election transfer mechanism. The enzyme is typically a homodimer. Mycobacterium smegmatis nitroreductase NfnB plays a role in resistance to benzothiazinone.


Pssm-ID: 380313 [Multi-domain]  Cd Length: 152  Bit Score: 104.59  E-value: 2.14e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEK--NTIRNILYHqngnagfADTidkLLIITGDtraft 241
Cdd:cd02136     5 RRSVRAFKDKPVPKETIEKILEAARRAPSGKNTQPWRVYVVTGKarERLKKAFFG-------APV---ALFLTMD----- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 242 ENESNQIFVDGGLFSMNLILALHSAGLGSCALntsYSYLKEHS-VKKIARIPNSERLIMMLAVGHTKQNFDVA--ASPRK 318
Cdd:cd02136    70 KVLGPWSWFDLGAFLQNLMLAAHALGLGTCPQ---GALAGYPDvVRKELGIPDDEELVCGIALGYPDPDAPVNqfRTPRE 146


                  ....*
gi 1086084971 319 PKYDF 323
Cdd:cd02136   147 PLEEF 151
Nitro_FMN_reductase cd02062
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 164-305 1.17e-24

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380311 [Multi-domain]  Cd Length: 139  Bit Score: 96.98  E-value: 1.17e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNILYHQNGNAGFADTIDKLLIITGDtrafTEN 243
Cdd:cd02062     4 RRSIRKFTDKPVPEEKLRKILEAARLAPSAGNLQPWRFIVVRDREKKEKLAKLAAPNQKFIAGAPVVIVVVAD----PDK 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1086084971 244 ESNQIFVDGGLFSMNLILALHSAGLGSCALntSYSYLKEHSVKKIARIPNSERLIMMLAVGH 305
Cdd:cd02062    80 SRPWALEDAGAAAQNLLLAAAALGLGSCWI--GGFDFREDKVRELLGIPENLRPVALIAIGY 139
Nitroreductase pfam00881
Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent ...
 164-305 2.50e-23

Nitroreductase family; The nitroreductase family comprises a group of FMN- or FAD-dependent and NAD(P)H-dependent enzymes able to metabolize nitrosubstituted compounds.


Pssm-ID: 425926 [Multi-domain]  Cd Length: 168  Bit Score: 94.38  E-value: 2.50e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-----------------------YHQNGN 220
Cdd:pfam00881   4 RRSVRKFDPEPVPKEVLEEILEAARRAPSAGNLQPWRFYVVTDGELRYRLAeaalelllvepaaalllllrrdaNLKLLL 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 221 AGFADTIDKLLIITGD----TRAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSER 296
Cdd:pfam00881  84 QDFLRGAPVLIVITASlstyLRKAAERAYREALLDAGAAAQNLLLAATSLGLGSCPI----GGFDAAAVRELLGLPDDER 159


                  ....*....
gi 1086084971 297 LIMMLAVGH 305
Cdd:pfam00881 160 LVGLIAVGY 168
MhqN-like cd02137
nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily ...
 159-323 7.07e-19

nitroreductase family protein similar to the NAD(P)H nitroreductase MhqN; A diverse subfamily of the nitroreductase family containing uncharacterized proteins; includes nitroreductases MhqN, YodC, YdgI, DrgA. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380314 [Multi-domain]  Cd Length: 147  Bit Score: 81.90  E-value: 7.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 159 DFVRCRYSVRNF-SNEPVDENLIFTAIETATYAPSVCNRQSWH---VHYYSEKNTIRNILYHQNgnagFADTIDKLLIIT 234
Cdd:cd02137     2 EVIKSRRSVRNFdPDHKIPKEELKEILELATLAPSSFNLQPWRfvvVRDPELKAKLAEAAYNQP----QVTTASAVILVL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 235 GDTraftenesnqifvDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGHTKQNFdvAA 314
Cdd:cd02137    78 GDL-------------NAGLAAMNLMLAAKAKGYDTCPM----GGFDKEKVAELLNLPDRYVPVLLIAIGKAADKA--PR 138


                  ....*....
gi 1086084971 315 SPRKPKYDF 323
Cdd:cd02137   139 SGRLPVDEV 147
nitroreductase cd20608
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 161-305 2.01e-18

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380329 [Multi-domain]  Cd Length: 145  Bit Score: 80.46  E-value: 2.01e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 161 VRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNiLYHQNGNAGFADTiDKLLIITGDT--- 237
Cdd:cd20608     4 IKTRRSVRRFSDKPVEEEKLEKILEAARLAPSWANKQCWRFIVVTDKETLSE-LAKKESPSNGWLK-DAPVIIVVCAdpk 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1086084971 238 RAFTENESNQIFVDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGH 305
Cdd:cd20608    82 DSGWLNGQNYYLVDAAIAMQNLMLAATDLGLGTCWI----GAFDEKKVKEILGIPENIRVVALTPLGY 145
nitroreductase cd20609
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 156-305 2.11e-17

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380330 [Multi-domain]  Cd Length: 145  Bit Score: 77.43  E-value: 2.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 156 EFNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNI--LYHQNGNAGFAdtidklLII 233
Cdd:cd20609     1 DFLELAKKRYSVRKFSDKPVEKEKLDKILEAGRLAPTAVNYQPQRILVVRSEEALEKLakATPRFFGAPLV------IVV 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1086084971 234 TGD-----TRAFTENESNQIfvDGGLFSMNLILALHSAGLGSCALNtsysYLKEHSVKKIARIPNSERLIMMLAVGH 305
Cdd:cd20609    75 CYDkdeswKRPYDGKDSGDI--DAAIVATHMMLAATELGLGTCWVG----NFDPEKVREAFNLPENLEPVAILPLGY 145
iodotyrosine_dehalogenase cd02144
iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the ...
 157-319 5.52e-16

iodotyrosine dehalogenase; Iodotyrosine dehalogenase catalyzes the removal of iodine from the 3, 5 positions of L-tyosine in thyroid, liver and kidney, using NADPH as electron donor. This enzyme is a homolog of the nitroreductase family. These enzymes are usually homodimers.


Pssm-ID: 380320  Cd Length: 192  Bit Score: 74.88  E-value: 5.52e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 157 FNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWH---VHYYSEKNTIRNI-------LYHQ-------NG 219
Cdd:cd02144     1 FYELMKKRRSVRDFSSEPVPREVIENAIRTAGTAPSGANTQPWTfvvVSDPEIKRKIREAaeeeekeFYEKrmgeewvWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 220 NAGFADTIDK--------LLIITGDTRAFTENES------NQIFVdgglfSMN---LILALHSAGLGSCalntSYSYLKE 282
Cdd:cd02144    81 LKPLGTNWEKpylteapyLIVVFKQKYGVLPDGKkkkhyyNEESV-----GIAvgiLLAALHNAGLVTL----THTPSPM 151

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1086084971 283 HSVKKIARIPNSERLIMMLAVGHTKQNFDVAASPRKP 319
Cdd:cd02144   152 PFLRDLLGRPKNEKPLLLLPVGYPAEDATVPDLKRKP 188
nitroreductase cd02139
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 157-319 8.57e-14

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380316 [Multi-domain]  Cd Length: 165  Bit Score: 68.27  E-value: 8.57e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 157 FNDFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNILYHQNGNAGFAD---TIdkllII 233
Cdd:cd02139     1 VYEAIKKRRSIRKYKPTPVEEEKLLRILEAARLAPSAKNRQPWRFIVVKDKELKEKLAEAANGQKFIAEapvVI----VA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 234 TGDTRAFTENESNQIF-VDGGLFSMNLILALHSAGLGSCALntsySYLKEHSVKKIARIPNSERLIMMLAVGHTKQnfDV 312
Cdd:cd02139    77 CADPSESGMGCGKPYYlVDVAIAMEHLVLAATEEGLGTCWI----GAFDEDKVKEILGIPEEYRVVALTPLGYPAE--EP 150


                  ....*..
gi 1086084971 313 AASPRKP 319
Cdd:cd02139   151 PPRPRKP 157
nitroreductase cd02150
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 164-309 3.78e-12

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers.


Pssm-ID: 380325 [Multi-domain]  Cd Length: 156  Bit Score: 63.39  E-value: 3.78e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIL-YHQNGNagFADTIDKLLIITGDTRafTE 242
Cdd:cd02150     4 RRSIRKYTDKPVEEEDIEKLLRAAMAAPSAGNQQPWHFIVVTDREKLDKIAeAHPYGK--MLKEAPLAIVVCGDPS--KE 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 243 NESNQIFVDGGLFSMNLILALHSAGLGSCALNTsysYLKE---HSVKKIARIPNSERLIMMLAVGHTKQN 309
Cdd:cd02150    80 KAPGYWVQDCSAATENILLAAHALGLGAVWLGV---YPFEervKAIREILNIPENIIPFCVIALGYPAEE 146
nitroreductase cd02151
nitroreductase family protein; A subfamily of the nitroreductase family containing ...
 159-305 8.02e-10

nitroreductase family protein; A subfamily of the nitroreductase family containing uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.often found to be homodimers..


Pssm-ID: 380326 [Multi-domain]  Cd Length: 157  Bit Score: 56.77  E-value: 8.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 159 DFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNILYHQNGNAGFADTIDKLLIITGDTr 238
Cdd:cd02151     1 ELLKKRRSIRKYTDEPIEEEKLEEILEAALLAPSSRNSRPVEFIVVDDKETLKKLSECKPHGSAFLKGAPAAIVVLADT- 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1086084971 239 aftenESNQIFV-DGGLFSMNLILALHSAGLGSCALN-----TSYSYLKEHSVKKIARIPNSERLIMMLAVGH 305
Cdd:cd02151    80 -----EKSDTWIeDASIAATYIQLAAESLGLGSCWIQirnreTQDGKTAEEYVRELLGIPENYRVLCIIALGY 147
nitroreductase cd20610
nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or ...
 161-304 1.13e-09

nitroreductase family protein; Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are described as NAD(P)H:FMN oxidoreductases, oxygen-insensitive nitroreductase, flavin reductase P, dihydropteridine reductase, NADH oxidase or NADH dehydrogenase.


Pssm-ID: 380331 [Multi-domain]  Cd Length: 167  Bit Score: 56.52  E-value: 1.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 161 VRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNIlyhqnGNA--GFADTI---------DK 229
Cdd:cd20610     1 IKKRRSIRKFKPDPVPKEDIEKILEAANWAPSGMNRQNWEFVVVKGGEKIEKI-----GISikKKNEEIarllekvfaEK 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 230 LLIITGDTRAFTEN------------ESNQIFVD-GGLFSM-----NLILALHSAGLGSCALnTSYSYlKEHSVKKIARI 291
Cdd:cd20610    76 PIRFRKFRRFFTLFggapvlvvvytePYKPPEERkPDLQSVsaaiqNLLLAAHALGLGTCWM-TGPLY-AEDEIEEILEI 153

                         170
                  ....*....|...
gi 1086084971 292 PNSERLIMMLAVG 304
Cdd:cd20610   154 PDDKELVAVTPLG 166
nitroreductase_FeS-like cd02143
nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family ...
 160-271 3.12e-09

nitroreductases with an N-terminal iron-sulfur cluster-binding domain; Members of this family utilize FMN as a cofactor. This family may be involved in the reduction of flavin or nitroaromatic compounds via an obligatory two-electron transfer. Nitroreductase is homodimer. Each subunit contains one FMN molecule.


Pssm-ID: 380319 [Multi-domain]  Cd Length: 187  Bit Score: 55.56  E-value: 3.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 160 FVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNI-------------LYHQNGNAGFADT 226
Cdd:cd02143     1 LLRSRRSIRRYKDKPVPRETLEKLLDIARYAPTGHNSQPVHWLVVDDPEKVRRLaelvidwmrelikEDPELAGKLFLDG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1086084971 227 IDKL--------------LIItgdtrAFTENESNQIFVDGGLFSMNLILALHSAGLGSC 271
Cdd:cd02143    81 IVAAwekgidvilrgaphLVV-----AHAPKDAPTPPVDCAIALTYLELAAPSLGLGTC 134
YdjA-like cd02135
nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the ...
 158-305 3.50e-08

nitroreductase family protein similar to Escherichia coli YdjA; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase YdjA from Escherichia coli. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer. Members of this family are also called NADH dehydrogenase, oxygen-insensitive NAD(P)H nitrogenase or dihydropteridine reductase.


Pssm-ID: 380312 [Multi-domain]  Cd Length: 162  Bit Score: 52.22  E-value: 3.50e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 158 NDFVRCRYSVRNFS-NEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSEKNTIRNI-----LYHQNGNAGFADTIDK-- 229
Cdd:cd02135     1 LELIKTRRSIRKFKlTGAPPEEQLEELLEAAMWAPNHGKLEPWRFIVVTGEGRERLAellaaAAAARAPGADPEKLEKar 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 230 --------LLIITGDtraftENESNQI-----FVDGGLFSMNLILALHSAGLGSCALNTSYSYLKEhsVKKIARIPNSER 296
Cdd:cd02135    81 ekalrapvVIAVVAK-----PDEDPKVpeweqYAAVGAAVQNLLLAAHALGLGAVWRTGPVTYDPA--VREALGLPEDER 153


                  ....*....
gi 1086084971 297 LIMMLAVGH 305
Cdd:cd02135   154 IVGFLYLGT 162
TdsD-like cd02138
nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase ...
 164-319 4.51e-08

nitroreductase similar to Burkholderia pseudomallei TdsD; A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to Burkholderia pseudomallei TdsD, may be involved in the processing of organosulfur compounds. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380315 [Multi-domain]  Cd Length: 174  Bit Score: 52.16  E-value: 4.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVhYYSEKNT-----IRNILyhQNGNAGFADTIDKLLIITGDTR 238
Cdd:cd02138     5 RWSPRAFSPEPISEEDLLSLFEAARWAPSCFNEQPWRF-VVARRDTeafekLLDLL--AEGNQSWAKNAPVLIVVLAKTE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 239 aFTENESNQI--FVDGGLFSMNLILALHSAGL------GscalntsYSYLKehsVKKIARIPNSERLIMMLAVGH----- 305
Cdd:cd02138    82 -FDHNGKPNRyaLFDTGAAVANLALQATALGLvvhqmaG-------FDPEK---AKEALGIPDEYEPITMIAIGYpgdpe 150

                         170
                  ....*....|....*...
gi 1086084971 306 ----TKQNFDVAASPRKP 319
Cdd:cd02138   151 slpeKLLEREEAPRTRKP 168
NfsA-like cd02146
nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin ...
 159-271 4.43e-06

nitroreductase similar to Escherichia coli NfsA; This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as an electron donor. Oxygen-insensitive nitroreductase, such as NfsA protein in Escherichia coli, catalyzes reduction of nitrocompounds using NADPH as electron donor.


Pssm-ID: 380322 [Multi-domain]  Cd Length: 229  Bit Score: 46.85  E-value: 4.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 159 DFVRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSW---HVHYYSEKNTIRNILYHQ---NGNAGF--------- 223
Cdd:cd02146     3 ETILNHRSVRKFTDEPLTDETLETLIAAAQSASTSSNLQAYsviVVTDPELREKLAELAGNQpyvAQAPVFlvfcadlyr 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1086084971 224 ----ADTIDKLLIITGDTRAFTenesnQIFVDGGLFSMNLILALHSAGLGSC 271
Cdd:cd02146    83 hqkiAEEAGGKDVGLDYLESFL-----VGVVDAALAAQNALVAAESLGLGIV 129
BluB cd02145
5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5, ...
 161-201 6.39e-04

5,6-dimethylbenzimidazole synthase; BluB catalyzes the O2-dependent conversion of FMNH2 to 5,6-dimethylbenzimidazole (DMB), a component of vitamin B12; is is a subfamily of the nitroreductase family; nitroreductases typically reduce their substrates by using NAD(P)H as electron donor and often use FMN as a cofactor.


Pssm-ID: 380321  Cd Length: 196  Bit Score: 40.03  E-value: 6.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1086084971 161 VRCRYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHV 201
Cdd:cd02145     4 IRWRRDVRHFRPDPVPEEVLERLLQAAHLAPSVGLMQPWRF 44
nitroreductase cd03370
uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus ...
 164-218 9.64e-04

uncharacterized nitroreductase family proteins; Nitroreductase family containing Thermus thermophilus NADH oxidase and other, uncharacterized proteins. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and nitroimidazoles. This process requires NAD(P)H as electron donor in an obligatory two-electron transfer and uses FMN as cofactor. The enzyme is typically a homodimer.


Pssm-ID: 380327 [Multi-domain]  Cd Length: 191  Bit Score: 39.61  E-value: 9.64e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1086084971 164 RYSVRNFSNEPVDENLIFTAIETATYAPSVCNRQSWHVHYYSE---KNTIRNILYHQN 218
Cdd:cd03370     8 RRSIRKYTQEPVPDEDLREILRLAGLAPSAWNIQPWRFVVVRDaelKEQLQAAAYGQA 65
TM1586_NiRdase pfam14512
Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase ...
 162-307 3.49e-03

Putative TM nitroreductase; Compared with the more traditional NADH oxidase/flavin reductase family, this family is a duplication, consisting of two similar domains arranged as the subunits of the dimeric NADH oxidase/flavin reductase with one conserved active site.


Pssm-ID: 405236 [Multi-domain]  Cd Length: 214  Bit Score: 38.04  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1086084971 162 RCRYSVRNFSNEPVDEnlifTAIETATYAPSVCNRQS-WHVHYYSEKNTIRNILYHQNGNAGFADTIdklLIITGDTRAF 240
Cdd:pfam14512   7 FKRHSVRKYTDEPIPE----ELLEELKNAIDEINKLSgLNIQLVIDDPDAFKGKAKYGKFKGVPNYI---AAYGEKDDDL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1086084971 241 TENesnqifvdGGLFSMNLILALHSAGLGSCALNTSYsylkeHSVKKIARIPNSERLIMMLAVGHTK 307
Cdd:pfam14512  80 LEN--------AGYYGEQIVLYATALGLGTCWVGGTY-----SKSKVKAKIKKGEKLVIVIAFGYGA 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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