|
Name |
Accession |
Description |
Interval |
E-value |
| MurF |
COG0770 |
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
1-443 |
0e+00 |
|
UDP-N-acetylmuramyl pentapeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl pentapeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440533 [Multi-domain] Cd Length: 451 Bit Score: 562.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 1 MNLSELSNITNGTLTG-IDTEFKNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKTNIPHIHVKN 79
Cdd:COG0770 3 LTLAEIAEATGGRLIGdPDLVVTGVSTDSRKIKPGDLFVALKGERFDGHDFVAQALAKGAAAALVSRPLPADLPLIVVDD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 80 TRQALIDLACFYRQHITIPVAAITGSCGKTTTRALLENILKQSGNVLASKKSFNNDIGLPLTLLKLNPSYNFVALEIGTN 159
Cdd:COG0770 83 TLKALQQLAAAHRARFNIPVIAITGSNGKTTTKEMLAAVLSTKGKVLATPGNFNNEIGVPLTLLRLPEDHEFAVLEMGMN 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 160 HPGEIAGLTKIAKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAmHRIITFAKN 239
Cdd:COG0770 163 HPGEIAYLARIARPDIAVITNIGPAHLEGFGSLEGIARAKGEIFEGLPPGGVAVLNADDPLLAALAERAK-ARVLTFGLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 240 NSADVTARDIKFTPDGkTTFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKKG 319
Cdd:COG0770 242 EDADVRAEDIELDEDG-TRFTLHTPGGELEVTLPLPGRHNVSNALAAAAVALALGLDLEEIAAGLAAFQPVKGRLEVIEG 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 320 FAGATIIDDSYNANPASVKAAITLL--THRAKNSILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYGKLSAQAAKT 397
Cdd:COG0770 321 AGGVTLIDDSYNANPDSMKAALDVLaqLPGGGRRIAVLGDMLELGEESEELHREVGELAAELGIDRLFTVGELARAIAEA 400
|
410 420 430 440
....*....|....*....|....*....|....*....|....*..
gi 1085149876 398 FG-ENAQHFDNHDALIESLKPQLQKDTTVLIKGSRGMKMEKVVEALC 443
Cdd:COG0770 401 AGgERAEHFEDKEELLAALKALLRPGDVVLVKGSRGMGLERVVEALK 447
|
|
| murF |
TIGR01143 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the ... |
26-442 |
5.51e-154 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; This family consists of the strictly bacterial MurF gene of peptidoglycan biosynthesis. This enzyme is almost always UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanyl ligase, but in a few species, MurE adds lysine rather than diaminopimelate. This enzyme acts on the product from MurE activity, and so is also subfamily rather than equivalog. Staphylococcus aureus is an example of species in this MurF protein would differ. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273468 [Multi-domain] Cd Length: 417 Bit Score: 442.86 E-value: 5.51e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 26 IDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKTNIPH--IHVKNTRQALIDLACFYRQHITIPVAAIT 103
Cdd:TIGR01143 1 TDSRAIKPGDLFIALKGERFDGHDFVEQALAAGAVAVVVDREVGPDNGLpqILVDDTLEALQALARAKRAKFSGKVIGIT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 104 GSCGKTTTRALLENILKQSGNVLASKKSFNNDIGLPLTLLKLNPSYNFVALEIGTNHPGEIAGLTKIAKPTIATVTMVAP 183
Cdd:TIGR01143 81 GSSGKTTTKEMLAAILSHKYKVFATPGNFNNEIGLPLTLLRAPGDHDYAVLEMGASHPGEIAYLAEIAKPDIAVITNIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 184 VHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAMHRIITFAKNNsADVTARDIKFTPDGKTTFTLFL 263
Cdd:TIGR01143 161 AHLEGFGSLEGIAEAKGEILQGLKENGIAVINADDPAFADLAKRLPNRNILSFGFEG-GDFVAKDISYSALGSTSFTLVA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 264 PNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLvEKKGFAGATIIDDSYNANPASVKAAITL 343
Cdd:TIGR01143 240 PGGEFEVSLPLLGRHNVMNALAAAALALELGIPLEEIAEGLAELKLVKGRF-EVQTKNGLTLIDDTYNANPDSMRAALDA 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 344 LTHRAKNSILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYGKLSAQAAKTFGENAQHFDNHDALIESLKPQLQKDT 423
Cdd:TIGR01143 319 LARFPGKKILVLGDMAELGEYSEELHAEVGRYANSLGIDLVFLVGEEAAVIYDSFGKQGKHFADKDELLAFLKTLVRKGD 398
|
410
....*....|....*....
gi 1085149876 424 TVLIKGSRGMKMEKVVEAL 442
Cdd:TIGR01143 399 VVLVKGSRSVKLEKVVEAL 417
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
22-442 |
2.29e-133 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 407.55 E-value: 2.29e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 22 KNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDV-KTNIPHIHVKNTRQALIDLACFYRQHITIPVA 100
Cdd:PRK11929 527 GAVSTDSRSVGRGELFVALRGENFDGHDYLPQAFAAGACAAVVERQVaDVDLPQIVVDDTRAALGRLATAWRARFSLPVV 606
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 101 AITGSCGKTTTRALLENILKQ---SGNVLASKKSFNNDIGLPLTLLKLNPSYNFVALEIGTNHPGEIAGLTKIAKPTIAT 177
Cdd:PRK11929 607 AITGSNGKTTTKEMIAAILAAwqgEDRVLATEGNFNNEIGVPLTLLRLRAQHRAAVFELGMNHPGEIAYLAAIAAPTVAL 686
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 178 VTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAMHRIITFAKNNSADVTA----RDIKFTP 253
Cdd:PRK11929 687 VTNAQREHQEFMHSVEAVARAKGEIIAALPEDGVAVVNGDDPYTAIWAKLAGARRVLRFGLQPGADVYAekiaKDISVGE 766
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 254 DGKTTFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKKGFAGATIIDDSYNAN 333
Cdd:PRK11929 767 AGGTRCQVVTPAGSAEVYLPLIGEHNLRNALAAIACALAAGASLKQIRAGLERFQPVAGRMQRRRLSCGTRIIDDTYNAN 846
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 334 PASVKAAITLLTHRAKNS-ILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYGKLSAQAAKTFGENAQ-HFDNHDAL 411
Cdd:PRK11929 847 PDSMRAAIDVLAELPNGPrALVLGDMLELGDNGPAMHREVGKYARQLGIDALITLGEAARDAAAAFGAGARgVCASVDEI 926
|
410 420 430
....*....|....*....|....*....|.
gi 1085149876 412 IESLKPQLQKDTTVLIKGSRGMKMEKVVEAL 442
Cdd:PRK11929 927 IAALRGALPEGDSVLIKGSRFMRLERVVDAL 957
|
|
| murF |
PRK10773 |
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed |
3-442 |
2.96e-126 |
|
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed
Pssm-ID: 182718 [Multi-domain] Cd Length: 453 Bit Score: 373.60 E-value: 2.96e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 3 LSELSNITNGTLTGIDTEFKNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKTNIPHIHVKNTRQ 82
Cdd:PRK10773 6 LSQLADILNGELQGADITIDAVTTDTRKVTPGCLFVALKGERFDAHDFADDAKAAGAGALLVSRPLDIDLPQLVVKDTRL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 83 ALIDLACFYRQHITIPVAAITGSCGKTTTRALLENILKQSGNVLASKKSFNNDIGLPLTLLKLNPSYNFVALEIGTNHPG 162
Cdd:PRK10773 86 AFGQLAAWVRQQVPARVVALTGSSGKTSVKEMTAAILRQCGNTLYTAGNLNNDIGVPLTLLRLTPEHDYAVIELGANHQG 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 163 EIAGLTKIAKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAMHRIITFAKN--N 240
Cdd:PRK10773 166 EIAYTVSLTRPEAALVNNLAAAHLEGFGSLAGVAKAKGEIFSGLPENGIAIMNADSNDWLNWQSVIGSKTVWRFSPNaaN 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 241 SADVTARDIKFTPDGkTTFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKKGF 320
Cdd:PRK10773 246 SVDFTATNIHVTSHG-TEFTLHTPTGSVDVLLPLPGRHNIANALAAAALAMSVGATLDAVKAGLANLKAVPGRLFPIQLA 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 321 AGATIIDDSYNANPASVKAAITLLTHRAKNSILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYGKLSAQAAKTFGe 400
Cdd:PRK10773 325 EGQLLLDDSYNANVGSMTAAAQVLAEMPGYRVMVVGDMAELGAESEACHRQVGEAAKAAGIDKVLSVGKLSHAISEASG- 403
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 1085149876 401 NAQHFDNHDALIESLKPQLQKDT--TVLIKGSRGMKMEKVVEAL 442
Cdd:PRK10773 404 VGEHFADKTALIARLKALLAEHQviTILVKGSRSAAMEEVVRAL 447
|
|
| PRK14093 |
PRK14093 |
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; ... |
24-442 |
2.74e-81 |
|
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional
Pssm-ID: 184501 [Multi-domain] Cd Length: 479 Bit Score: 258.94 E-value: 2.74e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 24 ISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRD----VKTNIPHIHVKNTRQALIDLACFYRQHITIPV 99
Cdd:PRK14093 31 ISIDSRTLAPGDAYFAIKGDVHDGHAFVAAALKAGAALAVVERAqrdkFAADAPLLVVDDVLAALRDLGRAARARLEAKV 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 100 AAITGSCGKTTTRALLENILKQSGNVLASKKSFNNDIGLPLTLLKLNPSYNFVALEIGTNHPGEIAGLTKIAKPTIATVT 179
Cdd:PRK14093 111 IAVTGSVGKTSTKEALRGVLGAQGETHASVASFNNHWGVPLSLARCPADARFAVFEIGMNHAGEIEPLVKMVRPHVAIIT 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 180 MVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAMH---RIITFAKNNSADVTARDIKFTPDGK 256
Cdd:PRK14093 191 TVEPVHLEFFSGIEAIADAKAEIFTGLEPGGAAVLNRDNPQFDRLAASARAAgiaRIVSFGADEKADARLLDVALHADCS 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 257 T----------TFTLFLPnknilislpllGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKK-GFAG--A 323
Cdd:PRK14093 271 AvhadilghdvTYKLGMP-----------GRHIAMNSLAVLAAAELAGADLALAALALSQVQPAAGRGVRHTlEVGGgeA 339
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 324 TIIDDSYNANPASVKAAITLLThRAKNS-----ILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYGKLSAQ--AAK 396
Cdd:PRK14093 340 TLIDESYNANPASMAAALGVLG-RAPVGpqgrrIAVLGDMLELGPRGPELHRGLAEAIRANAIDLVFCCGPLMRNlwDAL 418
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 1085149876 397 TFGENAQHFDNHDALIESLKPQLQKDTTVLIKGSRGMKMEKVVEAL 442
Cdd:PRK14093 419 SSGKRGGYAEDAAALESQVVAAIRAGDVIMVKGSLGSRMKTIVTAL 464
|
|
| PRK11930 |
PRK11930 |
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine ... |
2-442 |
5.88e-72 |
|
putative bifunctional UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase/alanine racemase; Provisional
Pssm-ID: 237026 [Multi-domain] Cd Length: 822 Bit Score: 242.17 E-value: 5.88e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 2 NLSELSNITNGTLTGI-DTEFKNISIDSRTVQ--SGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVD--RDVKTNIPH-- 74
Cdd:PRK11930 4 TLESISGILGAEGLGDkDAIIDQILTDSRSLSfpENTLFFALKGERNDGHRYIQELYEKGVRNFVVSeeKHPEESYPDan 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 75 -IHVKNTRQALIDLACFYRQHITIPVAAITGSCGKTTTRALLENILKQSGNVLASKKSFNNDIGLPLTLLKLNPSYNFVA 153
Cdd:PRK11930 84 fLKVKDPLKALQELAAYHRSQFDIPVIGITGSNGKTIVKEWLYQLLSPDYNIVRSPRSYNSQIGVPLSVWQLNEEHELGI 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 154 LEIGTNHPGEIAGLTKIAKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFegltSDGIAVI---NADDQHATFWKKMAAM 230
Cdd:PRK11930 164 FEAGISQPGEMEALQKIIKPTIGILTNIGGAHQENFRSIKQKIMEKLKLF----KDCDVIIyngDNELISSCITKSNLTL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 231 HRIITFAKNNSADVTARDIKFTPDgKTTFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPE 310
Cdd:PRK11930 240 KLISWSRKDPEAPLYIPFVEKKED-HTVISYTYKGEDFHFEIPFIDDASIENLIHCIAVLLYLGYSADQIQERMARLEPV 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 311 YGRLVEKKGFAGATIIDDSYNANPASVKAAITLLTHRAKNS--ILVFGDMLELGNIADEQHADIGIFAKNAGIKKLFCYG 388
Cdd:PRK11930 319 AMRLEVKEGINNCTLINDSYNSDLQSLDIALDFLNRRSQSKkkTLILSDILQSGQSPEELYRKVAQLISKRGIDRLIGIG 398
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 1085149876 389 K-LSAQAAKTFGENAQHFDNHDALIESLKPQLQKDTTVLIKGSRGMKMEKVVEAL 442
Cdd:PRK11930 399 EeISSEASKFEGTEKEFFKTTEAFLKSFAFLKFRNELILVKGARKFEFEQITELL 453
|
|
| MurE |
COG0769 |
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; ... |
23-375 |
3.56e-52 |
|
UDP-N-acetylmuramyl tripeptide synthase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramyl tripeptide synthase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440532 [Multi-domain] Cd Length: 459 Bit Score: 181.82 E-value: 3.56e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 23 NISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVK---TNIPHIHVKNTRQALIDLA-CFY---RQHI 95
Cdd:COG0769 1 GITYDSRKVKPGDLFVALPGARVDGHDFIAQAIARGAVAVVTEAPGAllaAGVPVIVVPDPRAALALLAaAFYghpSQKL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 96 TipVAAITGSCGKTTTRALLENILKQSGnvlasKKSfnndiGLpltllklnpsynfvaleIGTNH---PGEI--AGLT-- 168
Cdd:COG0769 81 K--LIGVTGTNGKTTTTYLLAQILRALG-----KKT-----GL-----------------IGTVGngiGGELipSSLTtp 131
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 169 ----------KIAKPTIATVTM-----------VAPV-------------HIEHFGTLEAIAREKGAIFEGLTSDGIAVI 214
Cdd:COG0769 132 ealdlqrllaEMVDAGVTHVVMevsshaldqgrVDGVrfdvavftnltrdHLDYHGTMEAYFAAKARLFDQLGPGGAAVI 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 215 NADDQHATFWKKMAAmHRIITFAKNNSADVTARDIKFTPDGkTTFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMN 294
Cdd:COG0769 212 NADDPYGRRLAAAAP-ARVITYGLKADADLRATDIELSADG-TRFTLVTPGGEVEVRLPLIGRFNVYNALAAIAAALALG 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 295 ISIENIKTGLETVQPEYGRL--VEKKGfaGATIIDDsYNANPASVKAAI-TLLTHRAKNSILVFG-----------DMle 360
Cdd:COG0769 290 IDLEEILAALEKLKGVPGRMerVDGGQ--GPTVIVD-YAHTPDALENVLeALRPHTKGRLIVVFGcggdrdrgkrpLM-- 364
|
410
....*....|....*
gi 1085149876 361 lGNIAdEQHADIGIF 375
Cdd:COG0769 365 -GEIA-ARLADVVIV 377
|
|
| Mur_ligase_M |
pfam08245 |
Mur ligase middle domain; |
102-282 |
8.75e-47 |
|
Mur ligase middle domain;
Pssm-ID: 462409 [Multi-domain] Cd Length: 199 Bit Score: 160.16 E-value: 8.75e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 102 ITGSCGKTTTRALLENILKQSGNVLA--------SKKSFNNDIGLPLTLLKL-NPSYNFVALEIGTNHPGEiAGLTKIAK 172
Cdd:pfam08245 1 VTGTNGKTTTTELIAAILSLAGGVIGtigtyigkSGNTTNNAIGLPLTLAEMvEAGAEYAVLEVSSHGLGE-GRLSGLLK 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 173 PTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMA--AMHRIITFAKNNSADVTARDIK 250
Cdd:pfam08245 80 PDIAVFTNISPDHLDFHGTMENYAKAKAELFEGLPEDGIAVINADDPYGAFLIAKLkkAGVRVITYGIEGEADLRAANIE 159
|
170 180 190
....*....|....*....|....*....|...
gi 1085149876 251 FTPDGkTTFTLF-LPNKNILISLPLLGEHNITN 282
Cdd:pfam08245 160 LSSDG-TSFDLFtVPGGELEIEIPLLGRHNVYN 191
|
|
| murE |
PRK00139 |
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional |
1-375 |
5.43e-36 |
|
UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase; Provisional
Pssm-ID: 234660 [Multi-domain] Cd Length: 460 Bit Score: 137.96 E-value: 5.43e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 1 MNLSELSNitngtltgiDTEFKNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVK--TNIPHIHVK 78
Cdd:PRK00139 4 MKLRDLLA---------PVEITGLTYDSRKVKPGDLFVALPGHKVDGRDFIAQAIANGAAAVVAEADGEagTGVPVIIVP 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 79 NTRQALIDLAC-FY---RQHITIpvAAITGSCGKTTTRALLENILKQSG----------NVLASKksfNNDIGL----PL 140
Cdd:PRK00139 75 DLRKALALLAAaFYghpSDKLKL--IGVTGTNGKTTTAYLLAQILRLLGektaligtlgNGIGGE---LIPSGLttpdAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 141 TLLKL-----NPSYNFVALEI-----------GTNHpgEIAGLTKIakptiatvtmvAPVHI-EHfGTLEAIAREKGAIF 203
Cdd:PRK00139 150 DLQRLlaelvDAGVTYAAMEVsshaldqgrvdGLKF--DVAVFTNL-----------SRDHLdYH-GTMEDYLAAKARLF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 204 EGLtsDGIAVINADDQHAtfwKKMAAMHRIITFAKNNsADVTARDIKFTPDGkTTFTLflpnkNILISLPLLGEHNITNA 283
Cdd:PRK00139 216 SEL--GLAAVINADDEVG---RRLLALPDAYAVSMAG-ADLRATDVEYTDSG-QTFTL-----VTEVESPLIGRFNVSNL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 284 LAAAAMAFAMNISIENIKTGLETVQPEYGRL--VEKKGfaGATIIDDsYNANPASVKAAI-TLLTHRAKNSILVFG---- 356
Cdd:PRK00139 284 LAALAALLALGVPLEDALAALAKLQGVPGRMerVDAGQ--GPLVIVD-YAHTPDALEKVLeALRPHAKGRLICVFGcggd 360
|
410 420
....*....|....*....|....*.
gi 1085149876 357 -------DMlelGNIAdEQHADIGIF 375
Cdd:PRK00139 361 rdkgkrpLM---GAIA-ERLADVVIV 382
|
|
| murE |
TIGR01085 |
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, ... |
18-356 |
4.61e-35 |
|
UDP-N-acetylmuramyl-tripeptide synthetase; Most members of this family are EC 6.3.2.13, UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase. An exception is Staphylococcus aureus, in which diaminopimelate is replaced by lysine in the peptidoglycan and MurE is EC 6.3.2.7. The Mycobacteria, part of the closest neighboring branch outside of the low-GC Gram-positive bacteria, use diaminopimelate. A close homolog, scoring just below the trusted cutoff, is found (with introns) in Arabidopsis thaliana. Its role is unknown. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273435 [Multi-domain] Cd Length: 464 Bit Score: 135.52 E-value: 4.61e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 18 DTEFKNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKT---NIPHIHVKNTRQALIDLACFYRQH 94
Cdd:TIGR01085 1 DLEVTGLTLDSREVKPGDLFVAIKGTHVDGHDFIHDAIANGAVAVVVERDVDFyvaPVPVIIVPDLRHALSSLAAAFYGH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 95 IT--IPVAAITGSCGKTTTRALLENILKQSG----------NVLASKKSFNNDIGL----PLTLLKL-----NPSYNFVA 153
Cdd:TIGR01085 81 PSkkLKVIGVTGTNGKTTTTSLIAQLLRLLGkktgligtigYRLGGNDLIKNPAALttpeALTLQSTlaemvEAGAQYAV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 154 LEIgTNHP---GEIAGLtkiaKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAm 230
Cdd:TIGR01085 161 MEV-SSHAlaqGRVRGV----RFDAAVFTNLSRDHLDFHGTMENYFAAKASLFTELGLKRFAVINLDDEYGAQFVKRLP- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 231 HRIITFAKNNSADVTARDIKFTPDGK----TTFTLFLPNKNILISLPLLGEHNITNA-LAAAAMAFAMNISIENIKTGLE 305
Cdd:TIGR01085 235 KDITVSAITQPADGRAQDIKITDSGYsfegQQFTFETPAGEGHLHTPLIGRFNVYNLlAALATLLHLGGIDLEDIVAALE 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1085149876 306 TVQPEYGRLVEKKGFAGATIIDDsYNANPASV-KAAITLLTHRAKNSILVFG 356
Cdd:TIGR01085 315 KFRGVPGRMELVDGGQKFLVIVD-YAHTPDALeKALRTLRKHKDGRLIVVFG 365
|
|
| PRK11929 |
PRK11929 |
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE ... |
27-371 |
5.77e-33 |
|
bifunctional UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase MurE/UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase MurF;
Pssm-ID: 237025 [Multi-domain] Cd Length: 958 Bit Score: 132.14 E-value: 5.77e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 27 DSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKTNIPH-----IHVKNTRQALIDLACFYRQHITIP--V 99
Cdd:PRK11929 35 DSREVQPGDLFVACRGAASDGRAFIDQALARGAAAVLVEAEGEDQVAAadalvLPVADLRKALGELAARWYGRPSEQlsL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 100 AAITGSCGKTTTRALLENILKQSGNVLASKKSFNNDIG---LPLTLLKLNP-------------SYNFVALE---IGTNH 160
Cdd:PRK11929 115 VAVTGTNGKTSCAQLLAQLLTRLGKPCGSIGTLGARLDgrlIPGSLTTPDAiilhrilarmraaGADAVAMEassHGLEQ 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 161 pGEIAGLTKIAkptiATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHAtfwKKMAAMH----RIITF 236
Cdd:PRK11929 195 -GRLDGLRIAV----AGFTNLTRDHLDYHGTMQDYEEAKAALFSKLPGLGAAVINADDPAA---ARLLAALprglKVGYS 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 237 AKNNSADVTARDIKFTPDGKTtFTLFLPNKNILISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRL-- 314
Cdd:PRK11929 267 PQNAGADVQARDLRATAHGQV-FTLATPDGSYQLVTRLLGRFNVSNLLLVAAALKKLGLPLAQIARALAAVSPVPGRMer 345
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 315 -VEKKGFAGATIIDDsYNANPASVKAAITLL---TH-RAKNSILVFG--------DMLELGNIAdEQHAD 371
Cdd:PRK11929 346 vGPTAGAQGPLVVVD-YAHTPDALAKALTALrpvAQaRNGRLVCVFGcggdrdkgKRPEMGRIA-AELAD 413
|
|
| murD |
TIGR01087 |
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation ... |
85-426 |
2.11e-23 |
|
UDP-N-acetylmuramoylalanine--D-glutamate ligase; [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273436 [Multi-domain] Cd Length: 433 Bit Score: 101.65 E-value: 2.11e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 85 IDLACfyrQHITIPVAAITGSCGKTTTRALLENILKQSGN--VLASkksfnnDIGLPLTLLKLNPSYNFVALEIGTnhpG 162
Cdd:TIGR01087 93 IELFL---RLVPLPVVAITGTNGKTTTTSLLYHLLKAAGLkaFLGG------NIGTPALEVLDQEGAELYVLELSS---F 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 163 EIAGlTKIAKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKmAAMHRIITFAKNNSA 242
Cdd:TIGR01087 161 QLET-TESLRPEIALILNISEDHLDWHGSFEDYVAAKLKIFARQTEGDVAVLNADDPRFARLAQ-KSKAQVIWFSVEKDA 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 243 DvtaRDIKFtPDGKttftLFLPNKNILISLPllGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKKGFAG 322
Cdd:TIGR01087 239 E---RGLCI-RDGG----LYLKPNDLEGSLL--GLHNAENILAAIALAKSLGLNLEAILEALRSFKGLPHRLEYVGQKNG 308
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 323 ATIIDDSYNANPASVKAAITllthRAKNSI-LVFGDMLELGNIADEQHAdigifAKNAgIKKLFCYGKLSAQAAKT---F 398
Cdd:TIGR01087 309 VHFYNDSKATNVHATLAALS----AFDNPViLIVGGDDKGADFSPLAPA-----AAGK-VKAVLAIGEDAAKIAPLlkeA 378
|
330 340
....*....|....*....|....*...
gi 1085149876 399 GENAQHFDNHDALIESLKPQLQKDTTVL 426
Cdd:TIGR01087 379 GLSVYLVESLEEAVQAAREVASPGDVVL 406
|
|
| MurC |
COG0773 |
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall ... |
101-427 |
6.56e-23 |
|
UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramate-alanine ligase MurC and related ligases, MurC/Mpl family is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440536 [Multi-domain] Cd Length: 451 Bit Score: 100.53 E-value: 6.56e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 101 AITGSCGKTTTRALLENILKQSGnvlaskksfnndiglpltllkLNPSYnFV---ALEIGTNhpgeiAGLTK----IA-- 171
Cdd:COG0773 108 AVAGTHGKTTTTSMLAHILEEAG---------------------LDPTF-LIggiLNNFGTN-----ARLGDgdyfVAea 160
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 172 ----------KPTIATVTMVAPVHIEHFGTLEAIARekgaIF----EGLTSDGIAVINADDQHAtfwKKMAAM--HRIIT 235
Cdd:COG0773 161 desdgsflhySPDIAVVTNIEADHLDIYGDLEAIKE----AFhefaRNVPFYGLLVLCADDPGL---RELLPRcgRPVIT 233
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 236 FAKNNSADVTARDIKFTPDGkTTFTLFLPNKNIL-ISLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRL 314
Cdd:COG0773 234 YGFSEDADYRAENIRIDGGG-STFDVLRRGEELGeVELNLPGRHNVLNALAAIAVALELGVDPEAIAEALASFKGVKRRF 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 315 vEKKGFA-GATIIDDsYNANPASVKAAITLLTHRAKNS--ILVF--------GDML-ELGNIADEqhADI----GIFA-- 376
Cdd:COG0773 313 -ELKGEVgGVTVIDD-YAHHPTEIAATLAAAREKYPDRrlVAVFqphrysrtRDFLdEFAEALSL--ADEvillDIYAar 388
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 1085149876 377 --KNAGIKklfcyGKLSAQAAKTFGENAQHFDNHDALIESLKPQLQKDTTVLI 427
Cdd:COG0773 389 ekPIPGVS-----SEDLAEAIRKRGKDVVYVPDLDELVEALAEIARPGDVVLT 436
|
|
| MurD |
COG0771 |
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ... |
85-341 |
5.21e-22 |
|
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis
Pssm-ID: 440534 [Multi-domain] Cd Length: 445 Bit Score: 97.84 E-value: 5.21e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 85 IDLACfyrQHITIPVAAITGSCGKTTTRALLENILKQSGnvlasKKSF---NndIGLP-LTLLKLNPSYNFVALEI---- 156
Cdd:COG0771 96 IELAY---RLSPAPIIAITGTNGKTTTTTLIGHILKAAG-----LRVAvggN--IGTPlLDLLLEPEPPDVYVLELssfq 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 157 --GTNHpgeiagltkiAKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHAtfwKKMAAmhrii 234
Cdd:COG0771 166 leTTPS----------LRPDVAVILNITPDHLDRHGSMEAYAAAKARIFANQTPDDYAVLNADDPLT---RALAE----- 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 235 tfaknnsaDVTARDIKFTPDGKTTFTLFLPNKNILI-----------SLPLLGEHNITNALAAAAMAFAMNISIENIKTG 303
Cdd:COG0771 228 --------EAKARVVPFSLKEPLEGGAGLEDGKLVDrasgeellpvdDLRLPGRHNLENALAALAAARALGVPPEAIREA 299
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1085149876 304 LETVQPEYGRL--VEKKGfaGATIIDDSYNANPASVKAAI 341
Cdd:COG0771 300 LRSFKGLPHRLefVAEIN--GVRFINDSKATNPDATLAAL 337
|
|
| murD |
PRK14106 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional |
98-339 |
1.20e-15 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional
Pssm-ID: 184511 [Multi-domain] Cd Length: 450 Bit Score: 78.47 E-value: 1.20e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 98 PVAAITGSCGKTTTRALLENILKQSG-NVLASkksfnNDIGLPL--TLLKLNPSYNFVAleigtnhpgEIAG----LTKI 170
Cdd:PRK14106 109 PIVAITGTNGKTTTTTLLGEIFKNAGrKTLVA-----GNIGYPLidAVEEYGEDDIIVA---------EVSSfqleTIKE 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 171 AKPTIATVTMVAPVHIEHFGTLEAIAREKGAIFEGLTSDGIAVINADDQHATFWKKMAAMhRIITFAKN----NSADVTA 246
Cdd:PRK14106 175 FKPKVGCILNITPDHLDRHKTMENYIKAKARIFENQRPSDYTVLNYDDPRTRSLAKKAKA-RVIFFSRKslleEGVFVKN 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 247 RDIKFTPDGKTTftlflpnKNILI-SLPLLGEHNITNALAAAAMAFAMNISIENIKTGLETVQPEYGRLVEKKGFAGATI 325
Cdd:PRK14106 254 GKIVISLGGKEE-------EVIDIdEIFIPGEHNLENALAATAAAYLLGISPDVIANTLKTFKGVEHRIEFVAEINGVKF 326
|
250
....*....|....*
gi 1085149876 326 IDDSYNANP-ASVKA 339
Cdd:PRK14106 327 INDSKGTNPdAAIKA 341
|
|
| PRK14022 |
PRK14022 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase; |
2-379 |
3.01e-14 |
|
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase;
Pssm-ID: 237588 [Multi-domain] Cd Length: 481 Bit Score: 74.30 E-value: 3.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 2 NLSELSNITNGTLTGIDTEFKNISIDSRTVQSGDCFFAiKGEYFDgHDFISDVAKKNVAAIIVDRDVKTNIPHIHVKNTR 81
Cdd:PRK14022 15 NFREIIDQDHYHYNYSGVQFDDISYDSRTADEGTLFFA-KGAYFK-HKFLQNAITQGLKLYVSEKDYEVGIPQVIVPDIK 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 82 QA--LIDLACF-YRQHiTIPVAAITGSCGKTTTRALLENILKQSG---------NVLASKKSFNNDIGLP--LTLLKLNP 147
Cdd:PRK14022 93 KAmsLIAMEFYdNPQH-KLKLLAFTGTKGKTTAAYFAYHILKQLHkpamlstmnTTLDGETFFKSALTTPesLDLFKMMA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 148 SynfvALEIGTNH-----------PGEIAGLTKiakpTIATVTMVAPVHI---EHfGTLEAIAREKGAIFEgltSDGIAV 213
Cdd:PRK14022 172 E----AVDNGMTHlimevssqaylVGRVYGLTF----DVGVFLNITPDHIgpiEH-PTFEDYFYHKRLLME---NSKAVV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 214 INADDQHATFWKKMAAMHRIITFAKNNSADVTAR-----DIKFTPDGKttftlflpnknilISLPLLGEHNITNALAAAA 288
Cdd:PRK14022 240 VNSDMDHFSELLEQVTPQEHDFYGIDSENQIMASnafsfEATGKLAGT-------------YDIQLIGKFNQENAMAAGL 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 289 MAFAMNISIENIKTGLETVQPEyGRLVEKKGFAGATIIDDsYNANPASVKAAITLL-THRAKNSILVFGdmlELGNIADE 367
Cdd:PRK14022 307 ACLRLGASLEDIQKGIAQTPVP-GRMEVLTQSNGAKVFID-YAHNGDSLNKLIDVVeEHQKGKLILLLG---AAGNKGES 381
|
410
....*....|..
gi 1085149876 368 QHADIGIFAKNA 379
Cdd:PRK14022 382 RRPDFGRVANRH 393
|
|
| Mur_ligase |
pfam01225 |
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes ... |
20-92 |
9.23e-14 |
|
Mur ligase family, catalytic domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460121 [Multi-domain] Cd Length: 84 Bit Score: 66.49 E-value: 9.23e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 20 EFKNISIDSRTVQSGDCFFAIKGEYFDGHDFISDVAKKNVAAIIVDRDVKT-----------NIPHIHVKNTRQALIDLA 88
Cdd:pfam01225 1 EIHFVGIDGRGMSPGALFLALKGYRVDGSDFIESLIALGAAAVVGHDAANNispdnpeleaaKVPGIPVIDRREALAELA 80
|
....
gi 1085149876 89 CFYR 92
Cdd:pfam01225 81 AAFY 84
|
|
| murC |
TIGR01082 |
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial ... |
71-341 |
1.55e-13 |
|
UDP-N-acetylmuramate--L-alanine ligase; This model describes the MurC protein in bacterial peptidoglycan (murein) biosynthesis. In a few species (Mycobacterium leprae, the Chlamydia), the amino acid may be L-serine or glycine instead of L-alanine. A related protein, UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase (murein tripeptide ligase) is described by model TIGR01081. [Cell envelope, Biosynthesis and degradation of murein sacculus and peptidoglycan]
Pssm-ID: 273433 [Multi-domain] Cd Length: 448 Bit Score: 71.95 E-value: 1.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 71 NIPHIHVKntrQALIDLACFYRqhitipVAAITGSCGKTTTRALLENILKQSG---NVL--ASKKSFNndiglplTLLKL 145
Cdd:TIGR01082 82 GIPVIRRA---EMLAELMRFRH------SIAVAGTHGKTTTTAMIAVILKEAGldpTVVvgGLVKEAG-------TNARL 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 146 NPSYNFVAleigtnhpgEI----AGLTKIaKPTIATVTMVAPVHIEHFG-TLEAIArekgAIFE----GLTSDGIAVINA 216
Cdd:TIGR01082 146 GSGEYLVA---------EAdesdASFLHL-QPNVAIVTNIEPDHLDTYGsSFERLK----AAFEkfihNLPFYGLAVICA 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 217 DDQHATFWKKMAamHRIITFAKNNSADVTARDIKF-TPDGKTTFTLFLPNKNIL-ISLPLLGEHNITNALAAAAMAFAMN 294
Cdd:TIGR01082 212 DDPVLRELVPKA--TEQVITYGGSGEDADYRAENIqQSGAEGKFSVRGKGKLYLeFTLNLPGRHNVLNALAAIAVALELG 289
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1085149876 295 ISIENIKTGLETVQpEYGRLVEKKG-FAGATIIDDsYNANPASVKAAI 341
Cdd:TIGR01082 290 IDFEAILRALANFQ-GVKRRFEILGeFGGVLLIDD-YAHHPTEIKATL 335
|
|
| FolC |
COG0285 |
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; ... |
94-430 |
1.25e-09 |
|
Folylpolyglutamate synthase/Dihydropteroate synthase [Coenzyme transport and metabolism]; Folylpolyglutamate synthase/Dihydropteroate synthase is part of the Pathway/BioSystem: Folate biosynthesis
Pssm-ID: 440054 [Multi-domain] Cd Length: 423 Bit Score: 59.73 E-value: 1.25e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 94 HITIPVAAITGSCGKTTTRALLENILKQSG---------------------NVLASK----------KSFNNDIGLPltl 142
Cdd:COG0285 37 QRKLPVIHVAGTNGKGSTAAMLESILRAAGyrvglytsphlvrfneririnGEPISDeelvealeevEPAVEEVDAG--- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 143 lklNPSYnFvalEIGT--------NHPGEIA----GL------TKIAKPTIATVTMVAPVHIEHFG-TLEAIAREKGAIF 203
Cdd:COG0285 114 ---PPTF-F---EVTTaaaflyfaEAPVDVAvlevGLggrldaTNVIDPLVSVITSIGLDHTDFLGdTLEEIAREKAGII 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 204 EgltsDGIAVINADDQHatfwkkmAAMHRIITFAKNNSADVTA--RDIKFTPDGKTTFTLFLPNKNIL-ISLPLLGEHNI 280
Cdd:COG0285 187 K----PGVPVVTGDQQP-------EALEVIEERAAELGAPLYRagRDFSVEEREGAVFSYQGPGGEYEdLPLPLLGAHQA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 281 TNALA-----AAAMAFAMNISIENIKTGLETVQ-PeyGRLvEKKGFAGATIIDdsyNA-NPASVKAAITLLTHRAKNS-- 351
Cdd:COG0285 256 ENAALalaalEALRELGLPISEEAIREGLANARwP--GRL-EVLSRGPLVILD---GAhNPAGARALAETLKELFPFRkl 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 352 ILVFGdML---ELGNIAD--EQHADIGIFAKNAG-----IKKLfcygklsAQAAKTFGENAQHFDNHDALIESLKPQLQK 421
Cdd:COG0285 330 HLVFG-MLadkDIEGMLAalAPLADEVIVTTPPSpraldAEEL-------AEAARELGLRVEVAPDVEEALEAALELADP 401
|
....*....
gi 1085149876 422 DTTVLIKGS 430
Cdd:COG0285 402 DDLILVTGS 410
|
|
| PRK14016 |
PRK14016 |
cyanophycin synthetase; Provisional |
97-306 |
6.85e-06 |
|
cyanophycin synthetase; Provisional
Pssm-ID: 237586 [Multi-domain] Cd Length: 727 Bit Score: 48.61 E-value: 6.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 97 IPVAAITGSCGKTTTRALLENILKQSGNV--LASKKsfnndiGLPL-----------------TLLKlNPSYNFVALEig 157
Cdd:PRK14016 480 IPIVAVTGTNGKTTTTRLIAHILKLSGKRvgMTTTD------GVYIdgrlidkgdctgpksarRVLM-NPDVEAAVLE-- 550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 158 tNHPGEI--AGLtkiAKPT--IATVTMVAPVHIEHFG--TLEAIAREKGAIFEGLTSDGIAVINADDQHAtfwKKMAAMH 231
Cdd:PRK14016 551 -TARGGIlrEGL---AYDRcdVGVVTNIGEDHLGLGGinTLEDLAKVKRVVVEAVKPDGYAVLNADDPMV---AAMAERC 623
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085149876 232 R--IITFAKNNSADVTARDIKftpDGKttFTLFLPNKNILIS-------------LPL----LGEHNITNALAAAAMAFA 292
Cdd:PRK14016 624 KgkVIFFSMDPDNPVIAEHRA---QGG--RAVYVEGDYIVLAeggweiriisladIPLtlggKAGFNIENALAAIAAAWA 698
|
250
....*....|....
gi 1085149876 293 MNISIENIKTGLET 306
Cdd:PRK14016 699 LGIDIELIRAGLRT 712
|
|
| Mur_ligase_C |
pfam02875 |
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase ... |
312-377 |
8.45e-06 |
|
Mur ligase family, glutamate ligase domain; This family contains a number of related ligase enzymes which have EC numbers 6.3.2.*. This family includes: MurC, MurD, MurE, MurF, Mpl and FolC. MurC, MurD, Mure and MurF catalyze consecutive steps in the synthesis of peptidoglycan. Peptidoglycan consists of a sheet of two sugar derivatives, with one of these N-acetylmuramic acid attaching to a small pentapeptide. The pentapeptide is is made of L-alanine, D-glutamic acid, Meso-diaminopimelic acid and D-alanyl alanine. The peptide moiety is synthesized by successively adding these amino acids to UDP-N-acetylmuramic acid. MurC transfers the L-alanine, MurD transfers the D-glutamate, MurE transfers the diaminopimelic acid, and MurF transfers the D-alanyl alanine. This family also includes Folylpolyglutamate synthase that transfers glutamate to folylpolyglutamate.
Pssm-ID: 460731 [Multi-domain] Cd Length: 87 Bit Score: 43.87 E-value: 8.45e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1085149876 312 GRLVEKKGFAGATIIDDsYNANPASVKAAITLLTHRAKNS-ILVFGDMLELGNiadEQHADIGIFAK 377
Cdd:pfam02875 3 GRLEVVGENNGVLVIDD-YAHNPDAMEAALRALRNLFPGRlILVFGGMGDRDA---EFHALLGRLAA 65
|
|
| |
