|
Name |
Accession |
Description |
Interval |
E-value |
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
5-400 |
1.62e-39 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 146.25 E-value: 1.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 5 LKALGKESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKA-----FS 79
Cdd:COG2244 1 LKKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEelrrlLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 80 TAYSCVLVTSVLFSAVLACFPSFWAGLGGlGAERGNLVLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVV 159
Cdd:COG2244 81 TALLLRLLLSLLLALLLLLLAPFIAALLG-EPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 160 LNIVFLTrFGMGIEGVFLAnllssllsvaavpkrftftfdrelfrklvdYSLPLLPAGLGAMAVQVIDRPILLRLSGEAA 239
Cdd:COG2244 160 LALLLAL-LGLGLWGLVLK------------------------------YSLPLLLSGLLGLLLTNLDRLLLGALLGPAA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 240 VGVYQANYRLGIFMVLLVSMFDQAWRPFFLERADKPDGPAV---FARVLTYFTLVLVWVGMALSFFIPDLARLqvagraL 316
Cdd:COG2244 209 VGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELrrlYRKALRLLLLLGLPLALGLALLAPPLLSL------L 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 317 IHESYWPGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMA 396
Cdd:COG2244 283 FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLL 362
|
....
gi 1085021423 397 LTVY 400
Cdd:COG2244 363 LLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
8-402 |
5.24e-26 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 109.17 E-value: 5.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 8 LGKESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKA-----FSTAY 82
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEkireiISTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 83 SCVLVTSVLFSAVLAcfpsFWAGLGGLGAERGNLVLYA-AAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLN 161
Cdd:cd13128 81 VLKLILGILALLLLF----LFAFLIAFYDPELVLLLYIlALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 162 IVFLtRFGMGIEGV--------FLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRPILLR 233
Cdd:cd13128 157 LILV-LLGGGLIGFalayliasVLSAILLLYIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 234 LSGEAAVGVYQANYRLGIFMVLLVSMFDQAWRPFF--LERADKPDGPAVFARVLTYFTLVLVWVGMALSFFIPDLARLqv 311
Cdd:cd13128 236 FLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRIseLYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITL-- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 312 agraLIHESYWPGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAA 391
Cdd:cd13128 314 ----LFGEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLIS 389
|
410
....*....|.
gi 1085021423 392 YCVMALTVYFY 402
Cdd:cd13128 390 EFIIFILLLYL 400
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
327-431 |
2.88e-08 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 52.57 E-value: 2.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 327 IVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMALTVYFYGRRL 406
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100
....*....|....*....|....*
gi 1085021423 407 FPVPYEFGRLGLIVFTALAISAPAL 431
Cdd:pfam14667 81 LGLRLLLRRLLKPLLAALVMGIVVY 105
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| RfbX |
COG2244 |
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ... |
5-400 |
1.62e-39 |
|
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 441845 [Multi-domain] Cd Length: 366 Bit Score: 146.25 E-value: 1.62e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 5 LKALGKESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKA-----FS 79
Cdd:COG2244 1 LKKLLKNTLWLLLGQLLGALLGFLLLPLLARLLGPEEYGLFALALSIVALLSVLADLGLSTALVRFIAEYREEelrrlLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 80 TAYSCVLVTSVLFSAVLACFPSFWAGLGGlGAERGNLVLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVV 159
Cdd:COG2244 81 TALLLRLLLSLLLALLLLLLAPFIAALLG-EPELALLLLLLALALLLSALSAVLLALLRGLERFKLLALINILSSLLSLL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 160 LNIVFLTrFGMGIEGVFLAnllssllsvaavpkrftftfdrelfrklvdYSLPLLPAGLGAMAVQVIDRPILLRLSGEAA 239
Cdd:COG2244 160 LALLLAL-LGLGLWGLVLK------------------------------YSLPLLLSGLLGLLLTNLDRLLLGALLGPAA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 240 VGVYQANYRLGIFMVLLVSMFDQAWRPFFLERADKPDGPAV---FARVLTYFTLVLVWVGMALSFFIPDLARLqvagraL 316
Cdd:COG2244 209 VGIYSAAYRLASLLLLLITALSQVLFPRLSRLLAEGDREELrrlYRKALRLLLLLGLPLALGLALLAPPLLSL------L 282
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 317 IHESYWPGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMA 396
Cdd:COG2244 283 FGPEYAEAAPVLPILALGALFLALSGVLSNLLLALGRTRLLLIISLIGAVLNLVLNLLLIPRYGLVGAAIATLLSYLVLL 362
|
....
gi 1085021423 397 LTVY 400
Cdd:COG2244 363 LLLL 366
|
|
| MATE_Wzx_like |
cd13128 |
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; ... |
8-402 |
5.24e-26 |
|
Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli Wzx and related proteins from other gram-negative bacteria are thought to act as flippases, assisting in the membrane translocation of lipopolysaccharides including those containing O-antigens. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240533 [Multi-domain] Cd Length: 402 Bit Score: 109.17 E-value: 5.24e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 8 LGKESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKA-----FSTAY 82
Cdd:cd13128 1 LAKNSGWLFVGNIISKLLGFLVRVYLARYLGPEGFGILSLALAFVGLFSIFADLGLPTALVREIARYRKEkireiISTSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 83 SCVLVTSVLFSAVLAcfpsFWAGLGGLGAERGNLVLYA-AAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLN 161
Cdd:cd13128 81 VLKLILGILALLLLF----LFAFLIAFYDPELVLLLYIlALSLPFSALNSLFRGIFQGFEKMKYIVIARIIESVLSLILA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 162 IVFLtRFGMGIEGV--------FLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRPILLR 233
Cdd:cd13128 157 LILV-LLGGGLIGFalayliasVLSAILLLYIYRKKILLPKFFSFDLKLAKELLRFSIPLALSGIFSLIYTRIDTIMLGY 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 234 LSGEAAVGVYQANYRLGIFMVLLVSMFDQAWRPFF--LERADKPDGPAVFARVLTYFTLVLVWVGMALSFFIPDLARLqv 311
Cdd:cd13128 236 FLGDAAVGIYNAAYRIAELLLFIPSAISTALFPRIseLYKNDKDELKKLLKKSFKYLFLISLPIAIGLFLFAEPIITL-- 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 312 agraLIHESYWPGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAA 391
Cdd:cd13128 314 ----LFGEEYLPAALVLQILAWGFLFIFLNGIFGSILQAIGKQKLTLKILLIGALLNVILNLLLIPKYGIIGAAIATLIS 389
|
410
....*....|.
gi 1085021423 392 YCVMALTVYFY 402
Cdd:cd13128 390 EFIIFILLLYL 400
|
|
| MATE_tuaB_like |
cd13127 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
16-411 |
2.95e-15 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides and participate in the biosynthesis of cell wall components such as teichuronic acid. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240532 [Multi-domain] Cd Length: 406 Bit Score: 77.53 E-value: 2.95e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 16 GLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKAFSTAYSCVLVTSVLFSAV 95
Cdd:cd13127 9 AISQVVVQLLQFVVTIILARLLTPEDFGLVAMATVFIAFAQLFSDLGLSSALIQRKDLTEEDLSTVFWLNLLLGLLLYLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 96 LACFPSFWAGLGGLgAERGNLVLYAAAILFLDSINVLPFADLR--MAHKPfyFAGVRLASITLNVVLNIVFLTrFGMG-- 171
Cdd:cd13127 89 LFLLAPLIAAFYNE-PELIPLLRVLSLSFLLSGLGSVPRALLQreLRFKK--LAIIELISTLVSGVVAIVLAL-LGFGvw 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 172 --IEGVFLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRPILLRLSGEAAVGVYQANYRL 249
Cdd:cd13127 165 alVAQQLVGALVSTVLLWILSRWRPRLSFSLASLKELLSFGSKLLGSNLLNYFSRNLDNLIIGKFLGAAALGYYSRAYRL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 250 GIFMV-LLVSMFDQAWRPFFLE-RADKPDGPAVFARVLTYFTLVLVWVGMALSFFIPDLARLqvagraLIHESYWPGLSI 327
Cdd:cd13127 245 ALLPVqNITGPITRVLFPALSRlQDDPERLRRAYLKALRLLALITFPLMVGLALLAEPLVLL------LLGEKWLPAVPI 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 328 VPVVLFAYLVNGIYvNLLAPIIISK-KTRVIMLATLAGALVNVAANFALIPkFGIYGPPWAAFAAYCVMALTVYFYGRRL 406
Cdd:cd13127 319 LQILALAGLFQPLS-SLNGSLLLALgRTDLLLKLGLIKAVLTVLALLIGIP-YGIIGVAIAYVIASLLSFPLNLYLAGRL 396
|
....*
gi 1085021423 407 FPVPY 411
Cdd:cd13127 397 IGISL 401
|
|
| Polysacc_synt_C |
pfam14667 |
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral ... |
327-431 |
2.88e-08 |
|
Polysaccharide biosynthesis C-terminal domain; This family represents the C-terminal integral membrane region of polysaccharide biosynthesis proteins.
Pssm-ID: 434111 [Multi-domain] Cd Length: 141 Bit Score: 52.57 E-value: 2.88e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 327 IVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMALTVYFYGRRL 406
Cdd:pfam14667 1 VLQILALSIIFLSLSTVLTSILQGLGRTKLALIALLIGALVKLILNLLLIPLFGIVGAAIATVISLLVVALLNLYYLRRY 80
|
90 100
....*....|....*....|....*
gi 1085021423 407 FPVPYEFGRLGLIVFTALAISAPAL 431
Cdd:pfam14667 81 LGLRLLLRRLLKPLLAALVMGIVVY 105
|
|
| Polysacc_synt_3 |
pfam13440 |
Polysaccharide biosynthesis protein; |
37-249 |
3.62e-08 |
|
Polysaccharide biosynthesis protein;
Pssm-ID: 404342 [Multi-domain] Cd Length: 293 Bit Score: 54.91 E-value: 3.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 37 LLPAEYGVVATVFSYIAFLNILYQYGMDQAYMRHYAHKEKAFSTAYSCVLVTSVLFSAVLACFPSFWAGLGGLgAERGNL 116
Cdd:pfam13440 6 LSPEDFGVVAIATVVISFANIFVDMGFSSALIQKKDITETDYSTVFTFNLIFGALIYLILFALAPLIASFYNQ-PELVPV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 117 VLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLNIVfLTRFGMGIE----GVFLANLLSSLLSVAAVPK 192
Cdd:pfam13440 85 LRVLALVLILNGLSSVQTALLRRDLRFKKLFKITLTSSVIGGIVGIV-LAYLGFGVWalviGTLAQQLLSLVLLWLASDW 163
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1085021423 193 RFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRPILLRLSGEAAVGVYQANYRL 249
Cdd:pfam13440 164 RPRLTFSLKVIKELFSFGSWLLLSNLLNYLARNLDNLIIGKVLGTAALGLYSVAYRL 220
|
|
| SpoVB |
COG5841 |
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle ... |
353-428 |
4.47e-06 |
|
Stage V sporulation protein SpoVB/SpoIIIF, required for spore cortex synthesis [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 444543 [Multi-domain] Cd Length: 532 Bit Score: 49.00 E-value: 4.47e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1085021423 353 KTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMALTVYFYGRRLFPVPYEFGRLGLIVFTALAISA 428
Cdd:COG5841 387 KQKIPVINLLIGLLVKIILNYLLVPLFGIYGAALATVIGYLVAAILNLAALKKYTGFKLDLRRRLLKPLLASLIMG 462
|
|
| Polysacc_synt |
pfam01943 |
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. ... |
8-268 |
4.83e-06 |
|
Polysaccharide biosynthesis protein; Members of this family are integral membrane proteins. Many members of the family are implicated in production of polysaccharide. The family includes RfbX part of the O antigen biosynthesis operon. The family includes SpoVB from Bacillus subtilis, which is involved in spore cortex biosynthesis.
Pssm-ID: 426523 [Multi-domain] Cd Length: 274 Bit Score: 48.07 E-value: 4.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 8 LGKESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQA---YMRHYAHKEKAFSTAYSC 84
Cdd:pfam01943 1 LLKNVIVLLLSQLITYLLAFVTLPYLARILGPEGFGLYAFALAFVGLLTIFTDFGFNAAlvrEIAKYREKYELVSLYWLN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 85 VLVTSVLFSAVLACFPsFWAGLGGLGAERGNLVLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLNIVF 164
Cdd:pfam01943 81 ALLVKLVLVLLFLLLP-LIAAFLGLPELAVLYRILALMFLLLPGVVQFRRGLFQGLERMKYALISQIVESLSRVILVFIA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 165 LTRFGmGIEGV----FLANLLSSLLSVAAVPKRFTFTF---DRELFRKLVDYSLPLLPAGLGAMAVQVIDRPILLRLSGE 237
Cdd:pfam01943 160 VFLPG-DIVAAllyqVLAALVGGIIALAVLRKIFRPRFvfpSLKLVRKLLSFGAPLFISSLAISLYTYIDSILLGLLLGA 238
|
250 260 270
....*....|....*....|....*....|..
gi 1085021423 238 AAVGVYQANYRLG-IFMVLLVSMFDQAWRPFF 268
Cdd:pfam01943 239 GAVGIYNAAYQLLvAIQGLLNPIVTAVLFPVF 270
|
|
| MATE_like_10 |
cd13125 |
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This ... |
10-407 |
3.10e-05 |
|
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; This family might function as a translocase for lipopolysaccharides, such as O-antigen. The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240530 [Multi-domain] Cd Length: 409 Bit Score: 45.99 E-value: 3.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 10 KESLIYGLSTVGARLLNFLLMPFYTHYLLPAEYGVVATVFSYIAFLNILYQYGMDQA-------YMRHYAHKEKAFSTAY 82
Cdd:cd13125 1 KVSSLSGISTLIKILAGLIINKVVAVYLGPSGVALLGQLQNFVTILQTIAGGGINNGvvkytaeYKDDEEKLARVWSTAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 83 SCVLVTSVLFSAVLACFPSFWAGLGGLGAERGNLVLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLNI 162
Cdd:cd13125 81 RITLILSILGGLLLLLFSKPLSSLLFGDIDYSWVFILLGLALPLFALNNLLLAILNGLKEIKRYALINIISSLIGLLVSV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 163 VFLTRFGmgIEG-----------VFLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRPIL 231
Cdd:cd13125 161 LLVYFYG--LKGallalvlnqslIFLVTLIYSRKQPWFKLKYLWGRLDKDIIKKLLKFSLMALVSALSLPLSQIIVRNIL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 232 LRLSGEAAVGVYQANYRLGIFMVLLVSMFDQAwrpFFLERADKPDGPAVFARVLTYFTLVLVWVGMALSFFIPDLARLQV 311
Cdd:cd13125 239 IRQLGWEAAGYWQAVWKISDVYLGFITTALST---YYLPRLSAIKDNKELKREVNKQLKVILPLVAIGALLIYLLRDLII 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 312 agRALIHESYWPGLSIVPVVLFAYLVNgIYVNLLAPIIISK-KTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFA 390
Cdd:cd13125 316 --QILFSEEFLPARELFLWQLIGDFFK-IASWLLGYILLAKgMTKLFIITEILFALLFVLLSLLFIPLFGLEGAGIAYAI 392
|
410
....*....|....*..
gi 1085021423 391 AYCVMALTVYFYGRRLF 407
Cdd:cd13125 393 NYILYLILMYFIFRKLL 409
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
17-397 |
4.06e-05 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 45.78 E-value: 4.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 17 LSTVGARLLNFLLMPFYTHYLL--PAEYGVVATVFSYIAFLNILYQYGMdQAYMRHYAHKEK------AFSTAYSCVLVT 88
Cdd:cd12082 6 LSMLLQTLYNLVDTFFLGRLLGdaLAAVGLAFPLIALLIALGVGLSVGT-SALISQAIGAGDeekarrVLVQSIVLAILL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 89 SVLFSAVLACFPSFWAGLGGLGAE----RGNLVLYAAAILFLDSINVLPFADLRMAHKPFYFAGVRLASITLNVVLN--- 161
Cdd:cd12082 85 GLLLAALLLFFSPLILSLLGAEEEvielAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNILLDpll 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 162 IVFLTRFGMGIEG------------VFLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAGLGAMAVQVIDRP 229
Cdd:cd12082 165 IFGLGPPELGIAGaalatvisyvigALLLLIYLRKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSLLSLGLLIIVA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 230 ILLRLSGEAAVGVYQANYRLGIFMVLLVSMFDQAWRPFF--LERADKPDGPAVFARVLTYFTLVLVWVGMALSFFIPD-L 306
Cdd:cd12082 245 IVAAFGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVgqNLGAGNFDRARRITWVALLIGLLIGAVLGLLILLFPEpI 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 307 ARLQVAGRALIHEsywpGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLA-GALVNVAANFALIP-KFGIYGP 384
Cdd:cd12082 325 LSLFTNDPEFLEL----AVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLsYWVVRLPLAYVLAYlGLGLYGI 400
|
410
....*....|...
gi 1085021423 385 PWAAFAAYCVMAL 397
Cdd:cd12082 401 WLALVISLILAAL 413
|
|
| MATE_SpoVB_like |
cd13124 |
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related ... |
329-409 |
5.21e-05 |
|
Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; The integral membrane protein SpoVB has been implicated in the biosynthesis of the peptidoglycan component of the spore cortex in Bacillus subtilis. This model represents a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).
Pssm-ID: 240529 [Multi-domain] Cd Length: 434 Bit Score: 45.54 E-value: 5.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 329 PVVLFAYLVNgiyvnLLAPIIISK-KTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMALTVYFYGRRLF 407
Cdd:cd13124 358 PSILFLSLQQ-----VTAAILQGLgKVKIPVINLLIGLLVKIVLNYVLIPIFGIYGAAIATVIGFLVAALLNLRALKKLL 432
|
..
gi 1085021423 408 PV 409
Cdd:cd13124 433 GF 434
|
|
| MATE_NorM_like |
cd13131 |
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ... |
353-405 |
3.25e-04 |
|
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.
Pssm-ID: 240536 [Multi-domain] Cd Length: 435 Bit Score: 42.87 E-value: 3.25e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 1085021423 353 KTRVIMLATLAGALVNVAANFALI------PKFGIYGPPWAAFAAYCVMALTVYFYGRR 405
Cdd:cd13131 149 RTRPAMVITLLALVLNIPLNYVLIfgkfglPALGGAGAGLATAIVYWLMFLALAFYIRR 207
|
|
| NorM |
COG0534 |
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms]; |
75-402 |
4.06e-04 |
|
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
Pssm-ID: 440300 [Multi-domain] Cd Length: 427 Bit Score: 42.82 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 75 EKAFSTAYSCVLVTSVLFSAVLACFPSFWAGLGGLGAE-----RGNLVLYAAAILFLDSINVLPFAdLRMAHKPFYFAGV 149
Cdd:COG0534 84 RRVLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEvlalaRDYLRIILLGLPFLLLFNVLNGI-LRGLGDTKTPMII 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 150 RLASITLNVVLNIVFLTRFGMGIEGV------------FLANLLSSLLSVAAVPKRFTFTFDRELFRKLVDYSLPLLPAG 217
Cdd:COG0534 163 MLIGNVLNIVLDPLLIFGGGLGVAGAalatvisqavsaLLLLYYLFRKRSLLRLRLRDLRPDRKILKRILRIGLPAGLQQ 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 218 LGAMAVQVIDRPILLRLsGEAAVGVYQANYRLGIFMVLLVSMFDQAWRPF--FLERADKPDGPAVFARVLTYFTLVLVWV 295
Cdd:COG0534 243 LAESLGFLVLNALVARL-GTAAVAAYGIALRIESLAFMPALGLGQAAQPLvgQNLGAGDYDRARRAARLALLLALGIGLL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 296 GMALSFFIPD-LARLQVAGRALIHEsywpGLSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGA-LVNVAANF 373
Cdd:COG0534 322 LALLLFLFPEpIIGLFTDDPEVIAL----AATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLwLVRLPLAY 397
|
330 340 350
....*....|....*....|....*....|
gi 1085021423 374 AL-IPKFGIYGPPWAAFAAYCVMALTVYFY 402
Cdd:COG0534 398 LLaFLGLGLTGVWLALPIGEVLRALLLLLR 427
|
|
| MurJ |
COG0728 |
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope ... |
324-443 |
2.94e-03 |
|
Lipid II flippase MurJ/MviN (peptidoglycan biosynthesis) [Cell wall/membrane/envelope biogenesis];
Pssm-ID: 440492 [Multi-domain] Cd Length: 503 Bit Score: 40.13 E-value: 2.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 324 GLSIVPVVLFAYLVNGIYVNllapiiisKKTRVIMLATLAGALVNVAANFALIPKFGIYGPPWAAFAAYCVMALTVYFYG 403
Cdd:COG0728 353 ALGLPAFALVKVLARAFYAR--------QDTRTPVRIAVIAVVVNIVLNLLLVPPLGHAGLALATSLSALVNALLLLVLL 424
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1085021423 404 RRLFPVPYEFGRLGLIVFTALAISAPALAGWGSGWQWTAY 443
Cdd:COG0728 425 RRRLGGLPLRGILRTLLKLLLASLVMGAVLWLLLRLLGDW 464
|
|
| MATE_like |
cd12082 |
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ... |
210-432 |
6.37e-03 |
|
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.
Pssm-ID: 240527 [Multi-domain] Cd Length: 420 Bit Score: 38.84 E-value: 6.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 210 SLPLLPAGLGAMAVQVIDRPILLRLSGE--AAVGVYQANYRLGIFMVLLVSMFDQAWRPFFLERADKPDGPAVFARVLtY 287
Cdd:cd12082 1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDalAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSI-V 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1085021423 288 FTLVLVWVGMALSFFI-PDLARLQVAGRALIHESYwpglSIVPVVLFAYLVNGIYVNLLAPIIISKKTRVIMLATLAGAL 366
Cdd:cd12082 80 LAILLGLLLAALLLFFsPLILSLLGAEEEVIELAA----TYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1085021423 367 VNVAANFALI-----PKFGIYGPPWAAFAAY---CVMALTVYFYGRRLFPVPYEFGRLGLIVF-TALAISAPALA 432
Cdd:cd12082 156 LNILLDPLLIfglgpPELGIAGAALATVISYvigALLLLIYLRKGKKILKFKLSLLKPDLELLrRLLRIGLPSAI 230
|
|
| |
