phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084922186   8 HPILVLDDEERV----RGLLMDylsecDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAE 77
Cdd:cd17569     1 PTILLVDDEPNIlkalKRLLRR-----EGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRER 69

acetoacetate metabolism transcriptional regulator AtoC;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEfigsAAAEKLCHH------F 83
Cdd:PRK11361    7 ILIVDDEDNVRRMLSTAFAL-QGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIK----ALKEMRSHEtrtpviL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1084922186  84 LVHTGSVDFAVsQSLKDLGMvqkDVFYKPVDAAEILARIRTLLK 127
Cdd:PRK11361   82 MTAYAEVETAV-EALRCGAF---DYVIKPFDLDELNLIVQRALQ 121

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHTGS 89
Cdd:COG2204     5 ILVVDDDPDIRRLLKELLERAG-YEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRALDPDLPVILLTGY 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1084922186  90 VDFAVSQSLKDLGmvQKDVFYKPVDAAEILARIRTLLKQ 128
Cdd:COG2204    84 GDVETAVEAIKAG--AFDYLTKPFDLEELLAAVERALER 120

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIgsaaaEKLCHH------- 82
Cdd:COG0745     4 ILVVEDDPDIRELLADALEREG-YEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVC-----RRLRARpsdipii 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1084922186  83 FLVHTGSVDFAVsqSLKDLGMVqkDVFYKPVDAAEILARIRTLLK 127
Cdd:COG0745    78 MLTARDDEEDRV--RGLEAGAD--DYLTKPFDPEELLARIRALLR 118

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHH--FLVHT 87
Cdd:COG3706     4 ILVVDDDPTNRKLLRRLLEA-AGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRTADipIIFLT 82

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1084922186  88 GSVDFAVSQSLKDLGMVqkDVFYKPVDAAEILARI 122
Cdd:COG3706    83 ALDDEEDRARALEAGAD--DYLTKPFDPEELLARV 115

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR) and similar domains; This family is composed of mostly uncharacterized response regulators with similarity to the REC domains of response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It contains an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. Members of this family contain a REC domain and various output domains including the cyclase homology domain (CHD) and the c-di-GMP phosphodiesterase domains, HD-GYP and EAL. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084922186   8 HPILVLDDEERV----RGLLMDylsecDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAE 77
Cdd:cd17569     1 PTILLVDDEPNIlkalKRLLRR-----EGYEVLTATSGEEALEILKQEPVDVVISDQRMPGMDGAELLKRVRER 69

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase response regulator RpfG and similar proteins; Cyclic di-GMP phosphodiesterase response regulator RpfG, together with sensory/regulatory protein RpfC, constitute a two-component system implicated in sensing and responding to the diffusible signal factor (DSF) that is essential for cell-cell signaling. RpfC is a hybrid sensor/histidine kinase that phosphorylates and activates RpfG, which degrades cyclic di-GMP to GMP, leading to the activation of Clp, a global transcriptional regulator that regulates a large set of genes in the DSF pathway. RpfG contains a CheY-like receiver domain attached to a histidine-aspartic acid-glycine-tyrosine-proline (HD-GYP) cyclic di-GMP phosphodiesterase domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHF--LVHT 87
Cdd:cd17551     3 ILIVDDNPTNLLLLEALLRSAGYLEVVSFTDPREALAWCRENPPDLILLDYMMPGMDGLEFIRRLRALPGLEDVpiVMIT 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1084922186  88 GSVDFAVSQSLKDLGMvqKDVFYKPVDAAEILARIRTL 125
Cdd:cd17551    83 ADTDREVRLRALEAGA--TDFLTKPFDPVELLARVRNL 118

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGsAAAEKLCH-HFLVHTG 88
Cdd:COG4567     7 LLLVDDDEAFARVLARALERRG-FEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIE-ALRERDPDaRIVVLTG 84

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1084922186  89 SVDFAVSQSLKDLGMVqkDVFYKPVDAAEILARIR 123
Cdd:COG4567    85 YASIATAVEAIKLGAD--DYLAKPADADDLLAALE 117

phosphoacceptor receiver (REC) domain of NarL (Nitrate/Nitrite response regulator L) family response regulators; The NarL family is one of the more abundant families of DNA-binding response regulators (RRs). Members of the NarL family contain a REC domain and a helix-turn-helix (HTH) DNA-binding output domain, with a majority of members containing a LuxR-type HTH domain. They function as transcriptional regulators. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFG-AGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:cd17535     1 VLIVDDHPLVREGLRRLLESEPDIEVVGeAADGEEALALLRELRPDVVLMDLSMPGMDGIEAL 63

DNA-binding response regulator, NarL/FixJ family, contains REC and HTH domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFG-AGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:COG2197     4 VLIVDDHPLVREGLRALLEAEPDIEVVGeAADGEEALELLEELRPDVVLLDIRMPGMDGLEAL 66

phosphoacceptor receiver (REC) domain of nitrogen assimilation regulatory protein NtrX and similar proteins; NtrX is part of the two-component regulatory system NtrY/NtrX that is involved in the activation of nitrogen assimilatory genes such as Gln. It is phosphorylated by the histidine kinase NtrY and interacts with sigma-54. NtrX is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. NtrC family response regulators are sigma54-dependent transcriptional activators. Also included in this subfamily is Aquifex aeolicus NtrC4. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084922186  10 ILVLDDEERVRGLLMDYLSecDE-FELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:cd17550     1 ILIVDDEEDIRESLSGILE--DEgYEVDTAADGEEALKLIKERRPDLVLLDIWLPDMDGLELL 61

phosphoacceptor receiver (REC) domain of hydrogen uptake protein regulator (HupR); Members of this subfamily are response regulator components of two-component systems that regulates hydrogenase activity, including HupR and HoxA. HupR is part of the HupT/HupR system that controls the synthesis of the membrane-bound [NiFe]hydrogenase, HupSL, of the photosynthetic bacterium Rhodobacter capsulatus. It belongs to the nitrogen regulatory protein C (NtrC) family of response regulators, which activate transcription by RNA polymerase (RNAP) in response to a change in the environment. HupR is an unusual member of this family as it activates transcription when unphosphorylated, and transcription is inhibited by phosphorylation. Proteins in this subfamily contain an N-terminal REC domain, a central sigma-54 interaction domain that lacks ATPase activity, and a C-terminal DNA-binding domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcdEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:cd17596     3 ILVVDDEVRSLEALRRTLEE--DFDVLTAASAEEALAILEEEWVQVILCDQRMPGTTGVEFL 62

phosphoacceptor receiver (REC) domain of nitrogen regulatory protein C 1 (NtrC1) from Aquifex aeolicus and similar NtrC family response regulators; NtrC family proteins are transcriptional regulators that have REC, AAA+ ATPase/sigma-54 interaction, and DNA-binding output domains. This subfamily of NtrC proteins include Aquifex aeolicus NtrC1 and Vibrio quorum-sensing signal integrator LuxO. The N-terminal REC domain of NtrC proteins regulate the activity of the protein and its phosphorylation controls the AAA+ domain oligomerization, while the central AAA+ domain participates in nucleotide binding, hydrolysis, oligomerization, and sigma54 interaction. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHT-- 87
Cdd:cd17572     1 VLLVEDSPSLAALYQEYLSD-EGYKVTHVETGKEALAFLSDQPPDVVLLDLKLPDMSGMEILKWIQERSLPTSVIVITah 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1084922186  88 GSVDFAVsqSLKDLGMvqKDVFYKPVDAAEILARIRTLLKQG 129
Cdd:cd17572    80 GSVDIAV--EAMRLGA--YDFLEKPFDADRLRVTVRNALKHR 117

phosphoacceptor receiver (REC) domain of KdpE-like OmpR family response regulators; KdpE is a component of the KdpD/KdpE two-component system (TCS) and is activated when histidine kinase KdpD senses a drop in external K+ concentration or upshift in ionic osmolarity, resulting in the expression of a heterooligomeric transporter KdpFABC. In addition, the KdpD/KdpE TCS is also an adaptive regulator involved in the virulence and intracellular survival of pathogenic bacteria. KdpE is a member of the OmpR family of DNA-binding response regulators that contain REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIG 72
Cdd:cd17620     1 ILVIEDEPQIRRFLRTALEAHG-YRVFEAETGQEGLLEAATRKPDLIILDLGLPDMDGLEVIR 62

first (D1) phosphoacceptor receiver (REC) domain of response regulator PleD and similar domains; PleD contains a REC domain (D1) with the phosphorylatable aspartate, a REC-like adaptor domain (D2), and the enzymatic diguanylate cyclase (DGC) domain, also called the GGDEF domain according to a conserved sequence motif, as its output domain. The GGDEF-containing PleD response regulators are global regulators of cell metabolism in some important human pathogens. This model describes D1 of PleD and similar domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVE 69
Cdd:cd17538     2 ILVVDDEPANRELLEALLSA-EGYEVLTADSGQEALALAEEELPDLILLDVMMPGMDGFE 60

phosphoacceptor receiver (REC) domain a fused response regulator with a thioredoxin reductase output domain; This family is composed of uncharacterized fusion proteins containing a REC domain and a thioredoxin reductase domain. Thioredoxin reductase catalyzes the reduction of thioredoxin and is thus a central component in the thioredoxin system. Fusion proteins containing REC and thioredoxin reductase domains could play an important role in the environmental regulation of the cellular dithiol-disulfide ratio. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084922186  10 ILVLDDEERV-----RGLLMDYlseCDEFELFGAGSGEEALEILRQ-----RPAALCVVDLRLPGMDGVEFIGSAAA 76
Cdd:cd17595     3 ILTVDDDPQVlravaRDLRRQY---GKDYRVLRADSGAEALDALKElklrgEAVALFLVDQRMPEMDGVEFLEKAME 76

phosphoacceptor receiver (REC) domain of cyclic di-GMP phosphodiesterase PA4781 and similar domains; Pseudomonas aeruginosa cyclic di-GMP phosphodiesterase PA4781 contains an N-terminal REC domain and a C-terminal catalytic HD-GYP domain, characteristics of RpfG family response regulators. PA4781 is involved in cyclic di-3',5'-GMP (c-di-GMP) hydrolysis/degradation in a two-step reaction via the linear intermediate pGpG to produce GMP. Its unphosphorylated REC domain prevents accessibility of c-di-GMP to the active site. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVE 69
Cdd:cd19920     1 ILIVDDVPDNLRLLSELLRAAG-YRVLVATDGQQALQRAQAEPPDLILLDVMMPGMDGFE 59

phosphoacceptor receiver (REC) domain of Thermotoga maritima response regulator RR468 and similar domains; Thermotoga maritima RR468 (encoded by gene TM0468) is the cognate response regulator (RR) of the class I histidine kinase HK853 (product of gene TM0853). HK853/RR468 comprise a two-component system (TCS) that couples environmental stimuli to adaptive responses. This subfamily also includes Fremyella diplosiphon complementary adaptation response regulator homolog RcaF, a small RR that is involved in four-step phosphorelays of the complementary chromatic adaptation (CCA) system that occurs in many cyanobacteria. Both RR468 and RcaF are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIgsaaaEKLCHH------- 82
Cdd:cd17552     4 ILVIDDEEDIREVVQACLEKLAGWEVLTASSGQEGLEKAATEQPDAILLDVMMPDMDGLATL-----KKLQANpetqsip 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1084922186  83 --FLvhTGSVDFAVSQSLKDLGMvqKDVFYKPVDAAEILARIRTLL 126
Cdd:cd17552    79 viLL--TAKAQPSDRQRFASLGV--AGVIAKPFDPLTLAEQIAKLL 120

second phosphoacceptor receiver (REC) domain of uncharacterized GGDEF domain proteins; This family is composed of uncharacterized PleD-like response regulators that contain two N-terminal REC domains and a C-terminal diguanylate cyclase output domain with the characteristic GGDEF motif at the active site. Unlike PleD which contains a REC-like adaptor domain, the second REC domain of these uncharacterized GGDEF domain proteins, described in this model, contains characteristic metal-binding and active site residues. PleD response regulators are global regulators of cell metabolism in some important human pathogens. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084922186   8 HPILVLDDEERVRGLLMDYLSECdEFELFGAGSGEEALEILRQRPA-ALCVVDLRLPGMDGVEFI 71
Cdd:cd17544     1 IKVLVVDDSATSRNHLRALLRRH-NFQVLEAANGQEALEVLEQHPDiKLVITDYNMPEMDGFELV 64

DNA-binding transcriptional regulator BaeR; Provisional

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084922186   1 MPMPETLHPILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGV 68
Cdd:PRK10710    4 LPIDENTPRILIVEDEPKLGQLLIDYLQAAS-YATTLLSHGDEVLPYVRQTPPDLILLDLMLPGTDGL 70

Ycf27; Reviewed

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186   3 MPETLHPILVLDDEERVRGLLMDYLSECDeFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDG------------VEF 70
Cdd:CHL00148    2 MENSKEKILVVDDEAYIRKILETRLSIIG-YEVITASDGEEALKLFRKEQPDLVILDVMMPKLDGygvcqeirkesdVPI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1084922186  71 IGSAAAEKlchhflvhtgsvdfaVSQSLKDLGMVQKDVFYKPVDAAEILARIRTLLK 127
Cdd:CHL00148   81 IMLTALGD---------------VSDRITGLELGADDYVVKPFSPKELEARIRSVLR 122

phosphoacceptor receiver (REC) domain of DrrD-like OmpR family response regulators; DrrD is a OmpR/PhoB homolog from Thermotoga maritima whose function is not yet known. This subfamily also includes Streptococcus agalactiae transcriptional regulatory protein DltR, part of the DltS/DltR two-component system (TCS), and Pseudomonas aeruginosa transcriptional activator protein PfeR, part of the PfeR/PfeS TCS, which activates expression of the ferric enterobactin receptor. The DltS/DltR TCS regulates the expression of the dlt operon, which comprises four genes (dltA, dltB, dltC, and dltD) that catalyze the incorporation of D-alanine residues into the lipoteichoic acids. Members of this subfamily belong to the OmpR/PhoB family, which comprises of two domains, an N-terminal receiver domain and a C-terminal DNA-binding winged helix-turn-helix effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  11 LVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHTGSV 90
Cdd:cd17625     1 LVVEDEKDLSEAITKHLKK-EGYTVDVCFDGEEGLEYALSGIYDLIILDIMLPGMDGLEVLKSLREEGIETPVLLLTALD 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1084922186  91 dfAVSQSLKDLGMVQKDVFYKPVDAAEILARIRTLLKQ 128
Cdd:cd17625    80 --AVEDRVKGLDLGADDYLPKPFSLAELLARIRALLRR 115

Two-component response regulator, AmiR/NasT family, consists of REC and RNA-binding antiterminator (ANTAR) domains [Signal transduction mechanisms, Transcription];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLChHFLVHTGS 89
Cdd:COG3707     6 VLVVDDEPLRRADLREGLREAGYEVVAEAADGEDAVELVRELKPDLVIVDIDMPDRDGLEAARQISEERPA-PVILLTAY 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1084922186  90 VDFAVSQSLKDLGMVQKDVfyKPVDAAEILARIRTLLKQ 128
Cdd:COG3707    85 SDPELIERALEAGVSAYLV--KPLDPEDLLPALELALAR 121

phosphoacceptor receiver (REC) domain of DivK and similar proteins; Caulobacter crescentus DivK is an essential response regulator that is involved in the complex phosphorelay pathways controlling both cell division and motility. It localizes cell cycle regulators to specific poles of the cell during division. DivK contains a stand-alone REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084922186  10 ILVLDDEERVRgLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:cd17548     2 ILIVEDNPLNM-KLARDLLESAGYEVLEAADGEEALEIARKEKPDLILMDIQLPGMDGLEAT 62

phosphoacceptor receiver (REC) domain of response regulator RocR; The response regulator RocR from some pathogens contains an N-terminal phosphoreceiver (REC) domain and a C-terminal EAL domain that possesses c-di-GMP specific phosphodiesterase activity. The RocR REC domain is phosphorylated and modulates its EAL domain enzymatic activity, regulating the local level of c-di-GMP. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIgSAAAEKLCHHFLVHTGS 89
Cdd:cd17530     3 VLVLDDDPFQCMMAATILEDLGPGNVDEADDGREALVILLCNAPDIIICDLKMPDMDGIEFL-RHLAESHSNAAVILMSG 81

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1084922186  90 VDFAVSQSLKDL----GMVQKDVFYKPVDAAEILA 120
Cdd:cd17530    82 LDGGILESAETLaganGLNLLGTLSKPFSPEELTE 116

phosphoacceptor receiver (REC) domain of PrrA-like OmpR family response regulators; The Mycobacterium tuberculosis PrrA is part of the PrrA/PrrB two-component system (TCS) that has been implicated in early intracellular multiplication and is essential for viability. Also included in this subfamily is Mycobacterium tuberculosis MprA, part of the MprAB TCS that regulates EspR, a key regulator of the ESX-1 secretion system, and is required for establishment and maintenance of persistent infection in a tissue- and stage-specific fashion. PrrA and MprA belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLsECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHTGS 89
Cdd:cd17627     1 ILVVDDDRAVRESLRRSL-RFEGYEVETAVDGAEALRVISGNRPDAVVLDVMMPRLDGLEVCRRLRAAGNDLPILVLTAR 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1084922186  90 VDfaVSQSLKDLGMVQKDVFYKPVDAAEILARIRTLLKQ 128
Cdd:cd17627    80 DS--VSDRVAGLDAGADDYLVKPFALEELLARVRALLRR 116

phosphoacceptor receiver (REC) domain of C4-dicarboxylic acid transport protein D (DctD) and similar proteins; C4-dicarboxylic acid transport protein D (DctD) is part of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. It is an activator of sigma(54)-RNA polymerase holoenzyme that uses the energy released from ATP hydrolysis to stimulate the isomerization of a closed promoter complex to an open complex capable of initiating transcription. DctD is a member of the NtrC family, characterized by a domain architecture containing an N-terminal REC domain, followed by a central sigma-54 interaction/ATPase domain, and a C-terminal DNA binding domain. The ability of the central domain to hydrolyze ATP and thus to interact effectively with a complex of RNA polymerase, sigma54, and promoter, is controlled by the phosphorylation status of the REC domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084922186  10 ILVLDDEERVRGLLMDYLsECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEF 70
Cdd:cd17549     1 VLLVDDDADVREALQQTL-ELAGFRVRAFADAEEALAALSPDFPGVVISDIRMPGMDGLEL 60

phosphoacceptor receiver (REC) domain of uncharacterized response regulators containing a CheC domain; This subfamily is composed of uncharacterized proteins containing an N-terminal REC domain and a C-terminal CheC domain that may function as the output/effector domain of a response regulator. CheC is a CheY-P phosphatase, affecting the level of phosphorylated CheY which controls the sense of flagella rotation and determine swimming behavior of chemotactic bacteria. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186   9 PILVLDDEERVRGLLMDYLSECDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHTG 88
Cdd:cd17593     2 KVLICDDSSMARKQLARALPADWDVEITFAENGEEALEILREGRIDVLFLDLTMPVMDGYEVLEALPVEQLETKVIVVSG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1084922186  89 SVDFAVSQSLKDLGMVqkDVFYKPVDAAEilarIRTLLKQ 128
Cdd:cd17593    82 DVQPEAKERVLELGAL--AFLKKPFDPEK----LAQLLEE 115

phosphoacceptor receiver (REC) domain of chemotaxis response regulator protein-glutamate methylesterase CheB and similar chemotaxis proteins; Methylesterase CheB is a chemotaxis response regulator with an N-terminal REC domain and a C-terminal methylesterase domain. Chemotaxis is a behavior known in motile bacteria that directs their movement in response to chemical gradients. CheB is a phosphorylation-activated response regulator involved in the reversible modification of bacterial chemotaxis receptors. It catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR. The CheB REC domain packs against the active site of the C-terminal domain and inhibits methylesterase activity by directly restricting access to the active site. Also included in this family is chemotaxis response regulator CheY, which contains a stand-alone REC domain, and an uncharacterized subfamily composed of proteins containing an N-terminal REC domain and a C-terminal CheY-P phosphatase (CheC) domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084922186  10 ILVLDDEERVRGLLMDYLSECDEFELFG-AGSGEEALEILRQRPAALCVVDLRLPGMDGVEFI 71
Cdd:cd17541     3 VLIVDDSAVMRKLLSRILESDPDIEVVGtARDGEEALEKIKELKPDVITLDIEMPVMDGLEAL 65

two-component response regulator VirG; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186  10 ILVLDDEERVRGLLMDYLSEcDEFELFGAGSGEEALEILRQRPAALCVVDLRLPGMDGVEFIGSAAAEKLCHHFLVHTGS 89
Cdd:PRK13856    4 VLVIDDDVAMRHLIVEYLTI-HAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSLATKSDVPIIIISGDR 82

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1084922186  90 VDFAVSQSLKDLGmvQKDVFYKPVDAAEILARIRTLLKQ 128
Cdd:PRK13856   83 LEEADKVVALELG--ATDFIAKPFGTREFLARIRVALRV 119

phosphoacceptor receiver (REC) domain of cyanobacterial phytochrome response regulator Rcp and similar domains; This family is composed of response regulators (RRs) that are members of phytochrome-associated, light-sensing two-component signal transduction pathways such as Synechocystis sp. Rcp1, Tolypothrix sp. RcpA, and Agrobacterium tumefaciens bacteriophytochrome response regulator AtBRR. They are stand-alone RRs containing only a REC domain with no output/effector domain. The REC domain itself functions as an effector domain. Also included in this family us Methanosaeta harundinacea methanogenesis regulatory protein FilR2, also a stand-alone RR. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084922186   9 PILVLDDEERVRGLLMDYLSECD-EFELFGAGSGEEALEILRQRPA-------ALCVVDLRLPGMDGVEF 70
Cdd:cd17557     1 TILLVEDNPGDAELIQEAFKEAGvPNELHVVRDGEEALDFLRGEGEyadaprpDLILLDLNMPRMDGFEV 70