|
Name |
Accession |
Description |
Interval |
E-value |
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
2-300 |
2.21e-91 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 273.27 E-value: 2.21e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEagatt 81
Cdd:COG1597 6 LLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:COG1597 81 TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVN--------GRYFLNVAGIGFDAEVVERANRALK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIM 241
Cdd:COG1597 153 RRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLR 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEA-PARFSVLPAALKIIV 300
Cdd:COG1597 233 LLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLV 292
|
|
| TIGR00147 |
TIGR00147 |
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ... |
2-300 |
2.24e-49 |
|
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161732 [Multi-domain] Cd Length: 293 Bit Score: 165.76 E-value: 2.24e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeagATT 81
Cdd:TIGR00147 5 PAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL----IQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TDV-AVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:TIGR00147 81 DDIpALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN-------KQYCFINMAGGGFGTEITTETPEKL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KA-LGDMPSYLMGL--FSTLMSYEnrdVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:TIGR00147 154 KAaLGSLSYILSGLmrMDTLQPFR---CEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084529439 238 DLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:TIGR00147 231 PALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
|
|
| PRK13337 |
PRK13337 |
putative lipid kinase; Reviewed |
2-292 |
8.34e-41 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183982 [Multi-domain] Cd Length: 304 Bit Score: 143.65 E-value: 8.34e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGATT 81
Cdd:PRK13337 5 RIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TdvaVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK13337 85 K---LGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKA--------NNRYFINIAGGGRLTELTYEVPSKLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 A-LGDMPSYLMGlFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK13337 154 TmLGQLAYYLKG-IEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELI 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVL 292
Cdd:PRK13337 233 HIATLALRGEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENL 284
|
|
| YegS_C |
pfam19279 |
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ... |
147-300 |
1.27e-34 |
|
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.
Pssm-ID: 437111 Cd Length: 158 Bit Score: 123.08 E-value: 1.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 147 GFDAEVVRATTE---KFKALgdmpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGD 223
Cdd:pfam19279 6 GVDARVNRRANRsrlLPGAL----SYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDD 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084529439 224 GFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:pfam19279 82 GLLDVVVIEAASRRTLLRLLPKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
3-104 |
2.68e-07 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 48.45 E-value: 2.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAGKTAKkwpQIMTLLKSLGLdfkHDVTEA----PGHAVELAKAAVKkgYKVVVSVGGDGTIHEIVNGLYEAG 78
Cdd:smart00046 2 VFVNPKSGGGKGEK---LLRKFRLLLNP---RQVFDLtkkgPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKRE 73
|
90 100
....*....|....*....|....*.
gi 1084529439 79 ATTTDVAVGIINTGTGADYIRTLGVP 104
Cdd:smart00046 74 LPLPEPPVAVLPLGTGNDLARSLGWG 99
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| LCB5 |
COG1597 |
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ... |
2-300 |
2.21e-91 |
|
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];
Pssm-ID: 441205 [Multi-domain] Cd Length: 295 Bit Score: 273.27 E-value: 2.21e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEagatt 81
Cdd:COG1597 6 LLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:COG1597 81 TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVN--------GRYFLNVAGIGFDAEVVERANRALK 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIM 241
Cdd:COG1597 153 RRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLR 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEA-PARFSVLPAALKIIV 300
Cdd:COG1597 233 LLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLV 292
|
|
| TIGR00147 |
TIGR00147 |
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ... |
2-300 |
2.24e-49 |
|
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 161732 [Multi-domain] Cd Length: 293 Bit Score: 165.76 E-value: 2.24e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeagATT 81
Cdd:TIGR00147 5 PAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL----IQL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TDV-AVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:TIGR00147 81 DDIpALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN-------KQYCFINMAGGGFGTEITTETPEKL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KA-LGDMPSYLMGL--FSTLMSYEnrdVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:TIGR00147 154 KAaLGSLSYILSGLmrMDTLQPFR---CEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLL 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084529439 238 DLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:TIGR00147 231 PALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
|
|
| PRK13337 |
PRK13337 |
putative lipid kinase; Reviewed |
2-292 |
8.34e-41 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183982 [Multi-domain] Cd Length: 304 Bit Score: 143.65 E-value: 8.34e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGATT 81
Cdd:PRK13337 5 RIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 TdvaVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK13337 85 K---LGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKA--------NNRYFINIAGGGRLTELTYEVPSKLK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 A-LGDMPSYLMGlFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK13337 154 TmLGQLAYYLKG-IEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELI 232
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVL 292
Cdd:PRK13337 233 HIATLALRGEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENL 284
|
|
| PRK13057 |
PRK13057 |
lipid kinase; |
4-300 |
6.14e-39 |
|
lipid kinase;
Pssm-ID: 183857 [Multi-domain] Cd Length: 287 Bit Score: 138.13 E-value: 6.14e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 4 IVNPAAGAGKTAKKwpQIMTLLKSLGLDFKHDVTEAPGHAVELAKAaVKKGYKVVVSVGGDGTIHEIVNGLYEagattTD 83
Cdd:PRK13057 3 LVNRHARSGRAALA--AARAALEAAGLELVEPPAEDPDDLSEVIEA-YADGVDLVIVGGGDGTLNAAAPALVE-----TG 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 84 VAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkGGqrkkRLFVNFAGIGFDAEVVRATTEKFKAL 163
Cdd:PRK13057 75 LPLGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWV----NG----HYFFNVASLGLSAELARRLTKELKRR 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 164 GDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDL--VIIDDITKpdLIM 241
Cdd:PRK13057 147 WGTLGYAIAALRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLysLEVAHWWR--LLA 224
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13057 225 LLPALRRGRHGEWPDVRAFRTTELELRTRKPRPINTDGELTTYTPAHFRVLPKALRVLA 283
|
|
| PRK11914 |
PRK11914 |
diacylglycerol kinase; Reviewed |
3-299 |
4.72e-35 |
|
diacylglycerol kinase; Reviewed
Pssm-ID: 237021 [Multi-domain] Cd Length: 306 Bit Score: 128.75 E-value: 4.72e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHeivNGLYEAGATtt 82
Cdd:PRK11914 13 VLTNPLSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVIS---NALQVLAGT-- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 83 DVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGR-RTVDLGVVEYTKGGQRkkrLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK11914 88 DIPLGIIPAGTGNDHAREFGIPTGDPEAAADVIVDGWtETVDLGRIQDDDGIVK---WFGTVAATGFDSLVTDRANRMRW 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIM-LNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK11914 165 PHGRM-RYNLAMLAELSKLRPLPFRLVLDGTEEIVTDLTLAaFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRTRLL 243
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEI-IPTLTsaVQADGELLGEAPARFSVLPAALKII 299
Cdd:PRK11914 244 RLFPTVFKGTHVELDEVSTARAKTVHVeCPGIN--AYADGDFACPLPAEISAVPGALQIL 301
|
|
| YegS_C |
pfam19279 |
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ... |
147-300 |
1.27e-34 |
|
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.
Pssm-ID: 437111 Cd Length: 158 Bit Score: 123.08 E-value: 1.27e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 147 GFDAEVVRATTE---KFKALgdmpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGD 223
Cdd:pfam19279 6 GVDARVNRRANRsrlLPGAL----SYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDD 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084529439 224 GFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:pfam19279 82 GLLDVVVIEAASRRTLLRLLPKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
|
|
| DAGK_cat |
pfam00781 |
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ... |
1-127 |
2.73e-32 |
|
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.
Pssm-ID: 425868 [Multi-domain] Cd Length: 125 Bit Score: 116.15 E-value: 2.73e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 1 MRIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGat 80
Cdd:pfam00781 2 LLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLA-- 79
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 1084529439 81 tTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVV 127
Cdd:pfam00781 80 -TRPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
|
|
| PRK13055 |
PRK13055 |
putative lipid kinase; Reviewed |
2-300 |
4.72e-30 |
|
putative lipid kinase; Reviewed
Pssm-ID: 237282 [Multi-domain] Cd Length: 334 Bit Score: 115.86 E-value: 4.72e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLD---FKhdVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeAG 78
Cdd:PRK13055 6 RLIYNPTSGQEIMKKNVADILDILEQAGYEtsaFQ--TTPEPNSAKNEAKRAAEAGFDLIIAAGGDGTINEVVNGI--AP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 79 ATTTDvAVGIINTGTGADYIRTLGVPRRYK-EACKCLLSRGRRTVDLGVVEYTKggqrkkrLFVNFAGIGFDAEVVRATT 157
Cdd:PRK13055 82 LEKRP-KMAIIPAGTTNDYARALKIPRDNPvEAAKVILKNQTIKMDIGRANEDK-------YFINIAAGGSLTELTYSVP 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 158 EKFKALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:PRK13055 154 SQLKSMFGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLF 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084529439 238 DLIMSIPRIYR-GTHLTHPKVTLMRAREVEIIPTLTSA--VQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13055 234 ELLHLMALILNgGKHIDDPRVIYIKTSKLTIEPLGDDRlmVNLDGEYGGDAPMTFENLKQHIEFFA 299
|
|
| PRK00861 |
PRK00861 |
putative lipid kinase; Reviewed |
3-300 |
6.57e-29 |
|
putative lipid kinase; Reviewed
Pssm-ID: 234850 [Multi-domain] Cd Length: 300 Bit Score: 112.02 E-value: 6.57e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAGKTAKKWPQIMTLLK-SLGLDFKhdVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIvnglyeAGATT 81
Cdd:PRK00861 7 LIFNPVAGQGNPEVDLALIRAILEpEMDLDIY--LTTPEIGADQLAQEAIERGAELIIASGGDGTLSAV------AGALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 82 -TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDlgvVEYTKGgqrkkRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:PRK00861 79 gTDIPLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVD---VAYCNG-----QPMILLAGIGFEAETVEEADREA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNA-DPGDGFFDLVIIddiTKPDL 239
Cdd:PRK00861 151 KNRFGILAYILSGLQQLRELESFEVEIETEDQIITTNAVAVTVANAAPPTSVLAQGPGAvIPDDGLLDVTIV---APKNL 227
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084529439 240 IMSIPRIY-------RGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK00861 228 AEAVAASYhllqtalQGNPAERDDIGYLRAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFA 295
|
|
| PRK13054 |
PRK13054 |
lipid kinase; Reviewed |
36-297 |
3.86e-24 |
|
lipid kinase; Reviewed
Pssm-ID: 237281 [Multi-domain] Cd Length: 300 Bit Score: 99.18 E-value: 3.86e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 36 VTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAgATTTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLL 115
Cdd:PRK13054 38 VTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQL-EGDARPALGILPLGTANDFATAAGIPLEPDKALKLAI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 116 SRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK-ALGDMPSYLMGL--FSTLMSYenrDVSIIVDGE 192
Cdd:PRK13054 117 EGRAQPIDLARVN-------DRTYFINMATGGFGTRVTTETPEKLKaALGGVAYLIHGLmrMDTLKPD---RCEIRGPDF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 193 HGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVII--DDITKPDLIMSIpriyRGTHLTHPKVTLMRAREVEIIPT 270
Cdd:PRK13054 187 HWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILpaPQELLPTLLSTL----TGGSEDNPNIIRARLPWLEIQAP 262
|
250 260
....*....|....*....|....*..
gi 1084529439 271 LTSAVQADGELLGEAPARFSVLPAALK 297
Cdd:PRK13054 263 HELTFNLDGEPLSGRHFRIEVLPAALR 289
|
|
| PRK13059 |
PRK13059 |
putative lipid kinase; Reviewed |
2-300 |
2.23e-21 |
|
putative lipid kinase; Reviewed
Pssm-ID: 183858 Cd Length: 295 Bit Score: 91.64 E-value: 2.23e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFK-HDVTEapGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGat 80
Cdd:PRK13059 5 KFIYNPYSGENAIISELDKVIRIHQEKGYLVVpYRISL--EYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLN-- 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 81 tTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:PRK13059 81 -IDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKIN--------DKYFINVASTGLFTDVSQKTDVNL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 K-ALGDMPSYLMGLfSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMpAPNADPGDGFFDLVIIDDITKPDL 239
Cdd:PRK13059 152 KnTIGKLAYYLKGL-EELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNL-AYKAEVDDGLLDVIIIKACPIIDL 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 240 IMSIPRIYRGTHLTHPK-VTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13059 230 IPLFIKVLKGEHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLG 291
|
|
| PRK12361 |
PRK12361 |
hypothetical protein; Provisional |
3-300 |
3.98e-13 |
|
hypothetical protein; Provisional
Pssm-ID: 183473 [Multi-domain] Cd Length: 547 Bit Score: 69.26 E-value: 3.98e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAGKTAKKWPQIMTLLKSlgldfKHDVT---EAPGH-AVELAKAAVKKGYKVVVSVGGDGTIHE----IVNgl 74
Cdd:PRK12361 247 LIANPVSGGGKWQEYGEQIQRELKA-----YFDLTvklTTPEIsAEALAKQARKAGADIVIACGGDGTVTEvaseLVN-- 319
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 75 yeagattTDVAVGIINTGTGADYIRTL-GVPRRY---KEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDA 150
Cdd:PRK12361 320 -------TDITLGIIPLGTANALSHALfGLGSKLipvEQACDNIIQGHTQRIDTARC--------NDRLMLLLVGIGFEQ 384
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 151 EVV-RATTEKFKALGDMpSYLMGLFSTLMSYENRDVSIIVDGEHGER-RICTIMLNNGRYA------GGGmmpAPNADpg 222
Cdd:PRK12361 385 KMIeSADRERKNALGQL-AYLDGLWRAVNENETLTLTVTLDDAEPQTiSTHSLVVANAAPFtsllaqGGG---EPNMT-- 458
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 223 DGFFDLVIIDDITKP--------DLIMS-IPRIYRGTHLTHpkvtlMRAREVEIIPTLTSAVQADGELLGEAPARFSVLP 293
Cdd:PRK12361 459 DGLLDITWLDSGGEPgeqllslaELALSgLGKEPEANKVHH-----AHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQP 533
|
....*..
gi 1084529439 294 AALKIIV 300
Cdd:PRK12361 534 ASLKVFV 540
|
|
| PLN02958 |
PLN02958 |
diacylglycerol kinase/D-erythro-sphingosine kinase |
3-282 |
9.07e-08 |
|
diacylglycerol kinase/D-erythro-sphingosine kinase
Pssm-ID: 215517 [Multi-domain] Cd Length: 481 Bit Score: 52.94 E-value: 9.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAgKTAKK--WPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAG-- 78
Cdd:PLN02958 116 VFVNPFGGK-KSASKifFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNGLLEREdw 194
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 79 ATTTDVAVGIINTGTGADYIRTL----GVPRRYKEACKCLLsRGRrTVDLGVVEYTKGGQRKKRLFVNFAGIGFDAEVvr 154
Cdd:PLN02958 195 KTAIKLPIGMVPAGTGNGMAKSLldsvGEPCSATNAVLAII-RGH-KCSLDVATILQGETKFFSVLMLAWGLVADIDI-- 270
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 155 aTTEKFKALGD--MPSYLMGLFSTLMSYENRDVSIIVDG--EHGERRIC------------------------------- 199
Cdd:PLN02958 271 -ESEKYRWMGSarLDFYGLQRILCLRQYNGRISFVPAPGfeAYGEPTSYngestskeesgkdkqhgyqgpdvklenldwr 349
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 200 -------TIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEI----- 267
Cdd:PLN02958 350 tikgpfvSVWLHNVPWGGEDTLAAPDAKFSDGYLDLILIKDCPKLALLALMTKLSDGTHVKSPYVMYLKVKAFVLepgpr 429
|
330
....*....|....*..
gi 1084529439 268 --IPTLTSAVQADGELL 282
Cdd:PLN02958 430 tdDPTKGGIIDSDGEVL 446
|
|
| DAGKc |
smart00046 |
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ... |
3-104 |
2.68e-07 |
|
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.
Pssm-ID: 214487 [Multi-domain] Cd Length: 124 Bit Score: 48.45 E-value: 2.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 3 IIVNPAAGAGKTAKkwpQIMTLLKSLGLdfkHDVTEA----PGHAVELAKAAVKkgYKVVVSVGGDGTIHEIVNGLYEAG 78
Cdd:smart00046 2 VFVNPKSGGGKGEK---LLRKFRLLLNP---RQVFDLtkkgPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKRE 73
|
90 100
....*....|....*....|....*.
gi 1084529439 79 ATTTDVAVGIINTGTGADYIRTLGVP 104
Cdd:smart00046 74 LPLPEPPVAVLPLGTGNDLARSLGWG 99
|
|
| PLN02204 |
PLN02204 |
diacylglycerol kinase |
3-74 |
4.10e-06 |
|
diacylglycerol kinase
Pssm-ID: 215126 [Multi-domain] Cd Length: 601 Bit Score: 47.96 E-value: 4.10e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084529439 3 IIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVE-LAKAAVK--KGYKVVVSVGGDGTIHEIVNGL 74
Cdd:PLN02204 164 VFVHPLSGKGSGSRTWETVSPIFIRAKVKTKVIVTERAGHAFDvMASISNKelKSYDGVIAVGGDGFFNEILNGY 238
|
|
|