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Conserved domains on  [gi|1084529439|gb|OGN90693|]
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hypothetical protein A2Z70_04445 [Chloroflexi bacterium RBG_13_48_17]

Protein Classification

diacylglycerol/lipid kinase family protein( domain architecture ID 11446635)

diacylglycerol/lipid kinase family protein may catalyze the ATP-dependent phosphorylation of diacylglycerol and/or other lipids, and is involved in the \tphospholipid biosynthetic process

CATH:  3.40.50.10330
EC:  2.7.1.-
Gene Ontology:  GO:0008654|GO:0001727|GO:0005524|GO:0016310
SCOP:  3001940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-300 2.21e-91

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


:

Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 273.27  E-value: 2.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEagatt 81
Cdd:COG1597     6 LLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:COG1597    81 TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVN--------GRYFLNVAGIGFDAEVVERANRALK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIM 241
Cdd:COG1597   153 RRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEA-PARFSVLPAALKIIV 300
Cdd:COG1597   233 LLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLV 292
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-300 2.21e-91

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 273.27  E-value: 2.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEagatt 81
Cdd:COG1597     6 LLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:COG1597    81 TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVN--------GRYFLNVAGIGFDAEVVERANRALK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIM 241
Cdd:COG1597   153 RRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEA-PARFSVLPAALKIIV 300
Cdd:COG1597   233 LLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLV 292
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-300 2.24e-49

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 165.76  E-value: 2.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeagATT 81
Cdd:TIGR00147   5 PAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL----IQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TDV-AVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:TIGR00147  81 DDIpALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN-------KQYCFINMAGGGFGTEITTETPEKL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KA-LGDMPSYLMGL--FSTLMSYEnrdVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:TIGR00147 154 KAaLGSLSYILSGLmrMDTLQPFR---CEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084529439 238 DLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:TIGR00147 231 PALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
PRK13337 PRK13337
putative lipid kinase; Reviewed
 2-292 8.34e-41

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 143.65  E-value: 8.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGATT 81
Cdd:PRK13337    5 RIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TdvaVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK13337   85 K---LGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKA--------NNRYFINIAGGGRLTELTYEVPSKLK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 A-LGDMPSYLMGlFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK13337  154 TmLGQLAYYLKG-IEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELI 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVL 292
Cdd:PRK13337  233 HIATLALRGEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENL 284
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 147-300 1.27e-34

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 123.08  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 147 GFDAEVVRATTE---KFKALgdmpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGD 223
Cdd:pfam19279   6 GVDARVNRRANRsrlLPGAL----SYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084529439 224 GFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:pfam19279  82 GLLDVVVIEAASRRTLLRLLPKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 3-104 2.68e-07

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 48.45  E-value: 2.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439    3 IIVNPAAGAGKTAKkwpQIMTLLKSLGLdfkHDVTEA----PGHAVELAKAAVKkgYKVVVSVGGDGTIHEIVNGLYEAG 78
Cdd:smart00046   2 VFVNPKSGGGKGEK---LLRKFRLLLNP---RQVFDLtkkgPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKRE 73

                           90       100
                   ....*....|....*....|....*.
gi 1084529439   79 ATTTDVAVGIINTGTGADYIRTLGVP 104
Cdd:smart00046  74 LPLPEPPVAVLPLGTGNDLARSLGWG 99
 
Name Accession Description Interval E-value
LCB5 COG1597
Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, ...
 2-300 2.21e-91

Phosphatidylglycerol kinase, diacylglycerol kinase family [Lipid transport and metabolism, General function prediction only];


Pssm-ID: 441205 [Multi-domain]  Cd Length: 295  Bit Score: 273.27  E-value: 2.21e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEagatt 81
Cdd:COG1597     6 LLIVNPASGRGRAARLLERLVAALRAAGLEVEVLETESPGDATELAREAAAEGADLVVAAGGDGTVNEVANGLAG----- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:COG1597    81 TGPPLGILPLGTGNDFARALGIPLDPEAALEALLTGRTRRIDLGRVN--------GRYFLNVAGIGFDAEVVERANRALK 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIM 241
Cdd:COG1597   153 RRLGKLAYVLAALRALLRYRPFRLRIELDGEEIEGEALLVAVGNGPYYGGGLRLAPDASLDDGLLDVVVVRPLSRLRLLR 232

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEA-PARFSVLPAALKIIV 300
Cdd:COG1597   233 LLPRLLRGRHLRHPGVRYFRAREVEIESDRPLPVQLDGEPLGLAtPLEFEVLPGALRVLV 292
TIGR00147 TIGR00147
lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been ...
 2-300 2.24e-49

lipid kinase, YegS/Rv2252/BmrU family; The E. coli member of this family, YegS has been purified and shown to have phosphatidylglycerol kinase activity. The member from M. tuberculosis, Rv2252, has diacylglycerol kinase activity. BmrU from B. subtilis is in an operon with multidrug efflux transporter Bmr, but is uncharacterized. [Unknown function, Enzymes of unknown specificity]


Pssm-ID: 161732 [Multi-domain]  Cd Length: 293  Bit Score: 165.76  E-value: 2.24e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeagATT 81
Cdd:TIGR00147   5 PAILNPTAGKSNDNKPLREVIMLLREEGMEIHVRVTWEKGDAARYVEEARKFGVDTVIAGGGDGTINEVVNAL----IQL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TDV-AVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:TIGR00147  81 DDIpALGILPLGTANDFARSLGIPEDLDKAAKLVIAGDARAIDMGQVN-------KQYCFINMAGGGFGTEITTETPEKL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KA-LGDMPSYLMGL--FSTLMSYEnrdVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:TIGR00147 154 KAaLGSLSYILSGLmrMDTLQPFR---CEIRGEGEHWQGEAVVFLVGNGRQAGGGQKLAPDASINDGLLDLRIFTNDNLL 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1084529439 238 DLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:TIGR00147 231 PALVLTLMSDEGKHTDNPNIIYGKASRIDIQTPHKITFNLDGEPLGGTPFHIEILPAHLRCRL 293
PRK13337 PRK13337
putative lipid kinase; Reviewed
 2-292 8.34e-41

putative lipid kinase; Reviewed


Pssm-ID: 183982 [Multi-domain]  Cd Length: 304  Bit Score: 143.65  E-value: 8.34e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGATT 81
Cdd:PRK13337    5 RIIYNPTSGRELFKKNLPDVLQKLEQAGYETSAHATTGPGDATLAAERAVERKFDLVIAAGGDGTLNEVVNGIAEKENRP 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 TdvaVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK13337   85 K---LGIIPVGTTNDFARALHVPRDIEKAADVIIEGHTVPVDIGKA--------NNRYFINIAGGGRLTELTYEVPSKLK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 A-LGDMPSYLMGlFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK13337  154 TmLGQLAYYLKG-IEMLPSLKATDVRIEYDGKLFQGEIMLFLLGLTNSVGGFEKLAPDASLDDGYFDLIIVKKANLAELI 232

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVL 292
Cdd:PRK13337  233 HIATLALRGEHIKHPKVIYTKANRIKVSSFDKMQLNLDGEYGGKLPAEFENL 284
PRK13057 PRK13057
lipid kinase;
4-300 6.14e-39

lipid kinase;


Pssm-ID: 183857 [Multi-domain]  Cd Length: 287  Bit Score: 138.13  E-value: 6.14e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   4 IVNPAAGAGKTAKKwpQIMTLLKSLGLDFKHDVTEAPGHAVELAKAaVKKGYKVVVSVGGDGTIHEIVNGLYEagattTD 83
Cdd:PRK13057    3 LVNRHARSGRAALA--AARAALEAAGLELVEPPAEDPDDLSEVIEA-YADGVDLVIVGGGDGTLNAAAPALVE-----TG 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  84 VAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVeytkGGqrkkRLFVNFAGIGFDAEVVRATTEKFKAL 163
Cdd:PRK13057   75 LPLGILPLGTANDLARTLGIPLDLEAAARVIATGQVRRIDLGWV----NG----HYFFNVASLGLSAELARRLTKELKRR 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 164 GDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDL--VIIDDITKpdLIM 241
Cdd:PRK13057  147 WGTLGYAIAALRVLRRSRPFTAEIEHDGRTERVKTLQVAVGNGRYYGGGMTVAHDATIDDGRLDLysLEVAHWWR--LLA 224

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1084529439 242 SIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13057  225 LLPALRRGRHGEWPDVRAFRTTELELRTRKPRPINTDGELTTYTPAHFRVLPKALRVLA 283
PRK11914 PRK11914
diacylglycerol kinase; Reviewed
 3-299 4.72e-35

diacylglycerol kinase; Reviewed


Pssm-ID: 237021 [Multi-domain]  Cd Length: 306  Bit Score: 128.75  E-value: 4.72e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   3 IIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHeivNGLYEAGATtt 82
Cdd:PRK11914   13 VLTNPLSGHGAAPHAAERAIARLHHRGVDVVEIVGTDAHDARHLVAAALAKGTDALVVVGGDGVIS---NALQVLAGT-- 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  83 DVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGR-RTVDLGVVEYTKGGQRkkrLFVNFAGIGFDAEVVRATTEKFK 161
Cdd:PRK11914   88 DIPLGIIPAGTGNDHAREFGIPTGDPEAAADVIVDGWtETVDLGRIQDDDGIVK---WFGTVAATGFDSLVTDRANRMRW 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 162 ALGDMpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIM-LNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLI 240
Cdd:PRK11914  165 PHGRM-RYNLAMLAELSKLRPLPFRLVLDGTEEIVTDLTLAaFGNTRSYGGGMLICPNADHTDGLLDITMVQSASRTRLL 243

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 241 MSIPRIYRGTHLTHPKVTLMRAREVEI-IPTLTsaVQADGELLGEAPARFSVLPAALKII 299
Cdd:PRK11914  244 RLFPTVFKGTHVELDEVSTARAKTVHVeCPGIN--AYADGDFACPLPAEISAVPGALQIL 301
YegS_C pfam19279
YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal ...
 147-300 1.27e-34

YegS C-terminal NAD kinase beta sandwich-like domain; This entry represents the C-terminal domain found in the YegS protein. It is related to the beta sandwich domain of NAD kinases. The structure of YegS reveals a two-domain protein with the active site crevice found between the two domains. The C-terminal domain contains 13 beta-strands and two alpha-helices. The likely substrate for YegS is phosphatidylglycerol.


Pssm-ID: 437111  Cd Length: 158  Bit Score: 123.08  E-value: 1.27e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 147 GFDAEVVRATTE---KFKALgdmpSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGD 223
Cdd:pfam19279   6 GVDARVNRRANRsrlLPGAL----SYPAAALRALATFRPLRYRVTVDGEVREFSAALVAVANSGYYGGGMRIAPDARVDD 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1084529439 224 GFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:pfam19279  82 GLLDVVVIEAASRRTLLRLLPKVYDGRHVRLPQVEVLRGREVRIEADRPLPAGADGEVLGPLPVRVEVLPGALRVLA 158
DAGK_cat pfam00781
Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts ...
 1-127 2.73e-32

Diacylglycerol kinase catalytic domain; Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologs. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family.


Pssm-ID: 425868 [Multi-domain]  Cd Length: 125  Bit Score: 116.15  E-value: 2.73e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   1 MRIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGat 80
Cdd:pfam00781   2 LLVIVNPKSGGGKGKKLLRKVRPLLNKAGVEVELVLTEGPGDALELAREAAEDGYDRIVVAGGDGTVNEVLNGLAGLA-- 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1084529439  81 tTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVV 127
Cdd:pfam00781  80 -TRPPLGIIPLGTGNDFARALGIPGDPEEALEAILKGQTRPVDVGKV 125
PRK13055 PRK13055
putative lipid kinase; Reviewed
 2-300 4.72e-30

putative lipid kinase; Reviewed


Pssm-ID: 237282 [Multi-domain]  Cd Length: 334  Bit Score: 115.86  E-value: 4.72e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLD---FKhdVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLyeAG 78
Cdd:PRK13055    6 RLIYNPTSGQEIMKKNVADILDILEQAGYEtsaFQ--TTPEPNSAKNEAKRAAEAGFDLIIAAGGDGTINEVVNGI--AP 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  79 ATTTDvAVGIINTGTGADYIRTLGVPRRYK-EACKCLLSRGRRTVDLGVVEYTKggqrkkrLFVNFAGIGFDAEVVRATT 157
Cdd:PRK13055   82 LEKRP-KMAIIPAGTTNDYARALKIPRDNPvEAAKVILKNQTIKMDIGRANEDK-------YFINIAAGGSLTELTYSVP 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 158 EKFKALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKP 237
Cdd:PRK13055  154 SQLKSMFGYLAYLAKGAELLPRVSPVPVRITYDEGVFEGKISMFFLALTNSVGGFEQIVPDAKLDDGKFTLIIVKTANLF 233

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1084529439 238 DLIMSIPRIYR-GTHLTHPKVTLMRAREVEIIPTLTSA--VQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13055  234 ELLHLMALILNgGKHIDDPRVIYIKTSKLTIEPLGDDRlmVNLDGEYGGDAPMTFENLKQHIEFFA 299
PRK00861 PRK00861
putative lipid kinase; Reviewed
 3-300 6.57e-29

putative lipid kinase; Reviewed


Pssm-ID: 234850 [Multi-domain]  Cd Length: 300  Bit Score: 112.02  E-value: 6.57e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   3 IIVNPAAGAGKTAKKWPQIMTLLK-SLGLDFKhdVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIvnglyeAGATT 81
Cdd:PRK00861    7 LIFNPVAGQGNPEVDLALIRAILEpEMDLDIY--LTTPEIGADQLAQEAIERGAELIIASGGDGTLSAV------AGALI 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  82 -TDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDlgvVEYTKGgqrkkRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:PRK00861   79 gTDIPLGIIPRGTANAFAAALGIPDTIEEACRTILQGKTRRVD---VAYCNG-----QPMILLAGIGFEAETVEEADREA 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 KALGDMPSYLMGLFSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMPAPNA-DPGDGFFDLVIIddiTKPDL 239
Cdd:PRK00861  151 KNRFGILAYILSGLQQLRELESFEVEIETEDQIITTNAVAVTVANAAPPTSVLAQGPGAvIPDDGLLDVTIV---APKNL 227

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084529439 240 IMSIPRIY-------RGTHLTHPKVTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK00861  228 AEAVAASYhllqtalQGNPAERDDIGYLRAKQVKITTDPPQKVVIDGEVVGTTPIEIECLPRSLKVFA 295
PRK13054 PRK13054
lipid kinase; Reviewed
 36-297 3.86e-24

lipid kinase; Reviewed


Pssm-ID: 237281 [Multi-domain]  Cd Length: 300  Bit Score: 99.18  E-value: 3.86e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  36 VTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAgATTTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLL 115
Cdd:PRK13054   38 VTWEKGDAARYVEEALALGVATVIAGGGDGTINEVATALAQL-EGDARPALGILPLGTANDFATAAGIPLEPDKALKLAI 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 116 SRGRRTVDLGVVEytkggqrKKRLFVNFAGIGFDAEVVRATTEKFK-ALGDMPSYLMGL--FSTLMSYenrDVSIIVDGE 192
Cdd:PRK13054  117 EGRAQPIDLARVN-------DRTYFINMATGGFGTRVTTETPEKLKaALGGVAYLIHGLmrMDTLKPD---RCEIRGPDF 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 193 HGERRICTIMLNNGRYAGGGMMPAPNADPGDGFFDLVII--DDITKPDLIMSIpriyRGTHLTHPKVTLMRAREVEIIPT 270
Cdd:PRK13054  187 HWQGDALVIGIGNGRQAGGGQQLCPEALINDGLLDLRILpaPQELLPTLLSTL----TGGSEDNPNIIRARLPWLEIQAP 262

                         250       260
                  ....*....|....*....|....*..
gi 1084529439 271 LTSAVQADGELLGEAPARFSVLPAALK 297
Cdd:PRK13054  263 HELTFNLDGEPLSGRHFRIEVLPAALR 289
PRK13059 PRK13059
putative lipid kinase; Reviewed
 2-300 2.23e-21

putative lipid kinase; Reviewed


Pssm-ID: 183858  Cd Length: 295  Bit Score: 91.64  E-value: 2.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   2 RIIVNPAAGAGKTAKKWPQIMTLLKSLGLDFK-HDVTEapGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAGat 80
Cdd:PRK13059    5 KFIYNPYSGENAIISELDKVIRIHQEKGYLVVpYRISL--EYDLKNAFKDIDESYKYILIAGGDGTVDNVVNAMKKLN-- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  81 tTDVAVGIINTGTGADYIRTLGVPRRYKEACKCLLSRGRRTVDLGVVEytkggqrkKRLFVNFAGIGFDAEVVRATTEKF 160
Cdd:PRK13059   81 -IDLPIGILPVGTANDFAKFLGMPTDIGEACEQILKSKPKKVDLGKIN--------DKYFINVASTGLFTDVSQKTDVNL 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 161 K-ALGDMPSYLMGLfSTLMSYENRDVSIIVDGEHGERRICTIMLNNGRYAGGGMMpAPNADPGDGFFDLVIIDDITKPDL 239
Cdd:PRK13059  152 KnTIGKLAYYLKGL-EELPNFRKLKVKVTSEEVNFDGDMYLMLVFNGQTAGNFNL-AYKAEVDDGLLDVIIIKACPIIDL 229

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1084529439 240 IMSIPRIYRGTHLTHPK-VTLMRAREVEIIPTLTSAVQADGELLGEAPARFSVLPAALKIIV 300
Cdd:PRK13059  230 IPLFIKVLKGEHLEDVNgLIYFKTDKLEIESNEEIVTDIDGERGPDFPLNIECIKGGLKVLG 291
PRK12361 PRK12361
hypothetical protein; Provisional
 3-300 3.98e-13

hypothetical protein; Provisional


Pssm-ID: 183473 [Multi-domain]  Cd Length: 547  Bit Score: 69.26  E-value: 3.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   3 IIVNPAAGAGKTAKKWPQIMTLLKSlgldfKHDVT---EAPGH-AVELAKAAVKKGYKVVVSVGGDGTIHE----IVNgl 74
Cdd:PRK12361  247 LIANPVSGGGKWQEYGEQIQRELKA-----YFDLTvklTTPEIsAEALAKQARKAGADIVIACGGDGTVTEvaseLVN-- 319

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  75 yeagattTDVAVGIINTGTGADYIRTL-GVPRRY---KEACKCLLSRGRRTVDLGVVeytkggqrKKRLFVNFAGIGFDA 150
Cdd:PRK12361  320 -------TDITLGIIPLGTANALSHALfGLGSKLipvEQACDNIIQGHTQRIDTARC--------NDRLMLLLVGIGFEQ 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 151 EVV-RATTEKFKALGDMpSYLMGLFSTLMSYENRDVSIIVDGEHGER-RICTIMLNNGRYA------GGGmmpAPNADpg 222
Cdd:PRK12361  385 KMIeSADRERKNALGQL-AYLDGLWRAVNENETLTLTVTLDDAEPQTiSTHSLVVANAAPFtsllaqGGG---EPNMT-- 458

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 223 DGFFDLVIIDDITKP--------DLIMS-IPRIYRGTHLTHpkvtlMRAREVEIIPTLTSAVQADGELLGEAPARFSVLP 293
Cdd:PRK12361  459 DGLLDITWLDSGGEPgeqllslaELALSgLGKEPEANKVHH-----AHAKKVTISSQKPIKYVIDGELFEDEDLTIEVQP 533


                  ....*..
gi 1084529439 294 AALKIIV 300
Cdd:PRK12361  534 ASLKVFV 540
PLN02958 PLN02958
diacylglycerol kinase/D-erythro-sphingosine kinase
 3-282 9.07e-08

diacylglycerol kinase/D-erythro-sphingosine kinase


Pssm-ID: 215517 [Multi-domain]  Cd Length: 481  Bit Score: 52.94  E-value: 9.07e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439   3 IIVNPAAGAgKTAKK--WPQIMTLLKSLGLDFKHDVTEAPGHAVELAKAAVKKGYKVVVSVGGDGTIHEIVNGLYEAG-- 78
Cdd:PLN02958  116 VFVNPFGGK-KSASKifFDVVKPLLEDADIQLTIQETKYQLHAKEVVRTMDLSKYDGIVCVSGDGILVEVVNGLLEREdw 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439  79 ATTTDVAVGIINTGTGADYIRTL----GVPRRYKEACKCLLsRGRrTVDLGVVEYTKGGQRKKRLFVNFAGIGFDAEVvr 154
Cdd:PLN02958  195 KTAIKLPIGMVPAGTGNGMAKSLldsvGEPCSATNAVLAII-RGH-KCSLDVATILQGETKFFSVLMLAWGLVADIDI-- 270

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 155 aTTEKFKALGD--MPSYLMGLFSTLMSYENRDVSIIVDG--EHGERRIC------------------------------- 199
Cdd:PLN02958  271 -ESEKYRWMGSarLDFYGLQRILCLRQYNGRISFVPAPGfeAYGEPTSYngestskeesgkdkqhgyqgpdvklenldwr 349

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439 200 -------TIMLNNGRYAGGGMMPAPNADPGDGFFDLVIIDDITKPDLIMSIPRIYRGTHLTHPKVTLMRAREVEI----- 267
Cdd:PLN02958  350 tikgpfvSVWLHNVPWGGEDTLAAPDAKFSDGYLDLILIKDCPKLALLALMTKLSDGTHVKSPYVMYLKVKAFVLepgpr 429

                         330
                  ....*....|....*..
gi 1084529439 268 --IPTLTSAVQADGELL 282
Cdd:PLN02958  430 tdDPTKGGIIDSDGEVL 446
DAGKc smart00046
Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger ...
 3-104 2.68e-07

Diacylglycerol kinase catalytic domain (presumed); Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. DAG can be produced from the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) by a phosphoinositide-specific phospholipase C and by the degradation of phosphatidylcholine (PC) by a phospholipase C or the concerted actions of phospholipase D and phosphatidate phosphohydrolase. This domain is presumed to be the catalytic domain. Bacterial homologues areknown.


Pssm-ID: 214487 [Multi-domain]  Cd Length: 124  Bit Score: 48.45  E-value: 2.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084529439    3 IIVNPAAGAGKTAKkwpQIMTLLKSLGLdfkHDVTEA----PGHAVELAKAAVKkgYKVVVSVGGDGTIHEIVNGLYEAG 78
Cdd:smart00046   2 VFVNPKSGGGKGEK---LLRKFRLLLNP---RQVFDLtkkgPAVALVIFRDVPD--FNRVLVCGGDGTVGWVLNALDKRE 73

                           90       100
                   ....*....|....*....|....*.
gi 1084529439   79 ATTTDVAVGIINTGTGADYIRTLGVP 104
Cdd:smart00046  74 LPLPEPPVAVLPLGTGNDLARSLGWG 99
PLN02204 PLN02204
diacylglycerol kinase
 3-74 4.10e-06

diacylglycerol kinase


Pssm-ID: 215126 [Multi-domain]  Cd Length: 601  Bit Score: 47.96  E-value: 4.10e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084529439   3 IIVNPAAGAGKTAKKWPQIMTLLKSLGLDFKHDVTEAPGHAVE-LAKAAVK--KGYKVVVSVGGDGTIHEIVNGL 74
Cdd:PLN02204  164 VFVHPLSGKGSGSRTWETVSPIFIRAKVKTKVIVTERAGHAFDvMASISNKelKSYDGVIAVGGDGFFNEILNGY 238
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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