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Conserved domains on  [gi|1084523958|gb|OGN85760|]
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exodeoxyribonuclease VII large subunit [Chloroflexi bacterium GWD2_49_16]

Protein Classification

exodeoxyribonuclease VII large subunit( domain architecture ID 11446309)

exodeoxyribonuclease VII large subunit is a component of bacterial exonuclease VII which degrades ssDNA and is involved in DNA repair and recombination

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
XseA COG1570
Exonuclease VII, large subunit [Replication, recombination and repair];
13-406 0e+00

Exonuclease VII, large subunit [Replication, recombination and repair];


:

Pssm-ID: 441178 [Multi-domain]  Cd Length: 400  Bit Score: 525.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  13 LSVTDLTRYLRQLMESDeiLQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNIN 92
Cdd:COG1570     6 LSVSELNRYIKRLLERD--FGNVWVEGEISNLKRHSSGHLYFTLKDEDAQIRCVMFRGRARRLKFRPEDGMKVLVRGRVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  93 VYEAGGQYQLNTDSIRSKGEGVLYQEFIRLKNLLEAEGFFEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPML 172
Cdd:COG1570    84 VYEPRGDYQLIVEDIEPAGLGALLAAFEQLKEKLAAEGLFDPERKRPLPFLPRRIGVVTSPTGAAIRDILTVLRRRFPAV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 173 MVTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARGGGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDF 252
Cdd:COG1570   164 EVLLYPVLVQGEGAAAEIAAAIERANARPEVDVIIVARGGGSLEDLWAFNDEAVARAIAASPIPVISAVGHETDFTIADF 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 253 AADLRAPTPTAAAEMATQVsINDIKVQIGEIYFQLVVAIREIQNQKRSEMRECRNRLQNCSPARRIQSSWQGLDTMTRRM 332
Cdd:COG1570   244 VADLRAPTPTAAAELAVPD-RAELLARLDQLRARLRRALRRRLERERQRLDRLRRRLVLASPERLLEQRRQRLDELEQRL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084523958 333 ITAQRHRLSLETIRLHGVVENLSSLNPLDVLKRGYAVVtRSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQVSG 406
Cdd:COG1570   323 RRALRRRLERKRQRLEALAARLEALSPLATLARGYAIV-RDADGKVVRSAAQVKPGDRLTIRLADGELEATVTE 395
 
Name Accession Description Interval E-value
XseA COG1570
Exonuclease VII, large subunit [Replication, recombination and repair];
13-406 0e+00

Exonuclease VII, large subunit [Replication, recombination and repair];


Pssm-ID: 441178 [Multi-domain]  Cd Length: 400  Bit Score: 525.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  13 LSVTDLTRYLRQLMESDeiLQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNIN 92
Cdd:COG1570     6 LSVSELNRYIKRLLERD--FGNVWVEGEISNLKRHSSGHLYFTLKDEDAQIRCVMFRGRARRLKFRPEDGMKVLVRGRVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  93 VYEAGGQYQLNTDSIRSKGEGVLYQEFIRLKNLLEAEGFFEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPML 172
Cdd:COG1570    84 VYEPRGDYQLIVEDIEPAGLGALLAAFEQLKEKLAAEGLFDPERKRPLPFLPRRIGVVTSPTGAAIRDILTVLRRRFPAV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 173 MVTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARGGGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDF 252
Cdd:COG1570   164 EVLLYPVLVQGEGAAAEIAAAIERANARPEVDVIIVARGGGSLEDLWAFNDEAVARAIAASPIPVISAVGHETDFTIADF 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 253 AADLRAPTPTAAAEMATQVsINDIKVQIGEIYFQLVVAIREIQNQKRSEMRECRNRLQNCSPARRIQSSWQGLDTMTRRM 332
Cdd:COG1570   244 VADLRAPTPTAAAELAVPD-RAELLARLDQLRARLRRALRRRLERERQRLDRLRRRLVLASPERLLEQRRQRLDELEQRL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084523958 333 ITAQRHRLSLETIRLHGVVENLSSLNPLDVLKRGYAVVtRSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQVSG 406
Cdd:COG1570   323 RRALRRRLERKRQRLEALAARLEALSPLATLARGYAIV-RDADGKVVRSAAQVKPGDRLTIRLADGELEATVTE 395
xseA TIGR00237
exodeoxyribonuclease VII, large subunit; This family consist of exodeoxyribonuclease VII, ...
14-404 0e+00

exodeoxyribonuclease VII, large subunit; This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA]


Pssm-ID: 272979 [Multi-domain]  Cd Length: 389  Bit Score: 515.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  14 SVTDLTRYLRQLMESDeILQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNINV 93
Cdd:TIGR00237   1 SVSELNRYIKELLERD-FLPNVWVEGEISNLKRHSSGHLYFTLKDEKAQIRCVMFRSRARRLKFRPEEGMKVLVRGRVSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  94 YEAGGQYQLNTDSIRSKGEGVLYQEFIRLKNLLEAEGFFEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPMLM 173
Cdd:TIGR00237  80 YEPRGSYQLIVEDIEPAGLGELYLAFEQLKEKLAAEGLFDPERKKPLPRFPKRIGVITSPTGAAIRDILNVLRRRWPLVE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 174 VTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARGGGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDFA 253
Cdd:TIGR00237 160 IVLYPALVQGEGAAASIIAAIERLNARGDVDVIIIGRGGGSIEDLWAFNDEAVARAIAASPIPVISAVGHETDFTIADFV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 254 ADLRAPTPTAAAEMATQvSINDIKVQIGEIYFQLVVAIREIQNQKRSEMRECRNRLQNCSPARRIQSSWQGLDTMTRRMI 333
Cdd:TIGR00237 240 ADLRAPTPTAAAELAVP-DRAELLQRLDQLRERLRRALQRRLERERQRLDRLRSRLVLASPERLLERQRQRLDRLEQRLK 318
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084523958 334 TAQRHRLSLETIRLHGVVENLSSLNPLDVLKRGYAVVtRSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQV 404
Cdd:TIGR00237 319 RALRRRLERKRQRLELLAARLEALSPLATLKRGYAIV-RDEDGKVVRSAKQLKPGDELTIRLADGEIKARV 388
Exonuc_VII_L pfam02601
Exonuclease VII, large subunit; This family consist of exonuclease VII, large subunit EC:3.1. ...
132-403 7.89e-112

Exonuclease VII, large subunit; This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.


Pssm-ID: 426865  Cd Length: 264  Bit Score: 328.62  E-value: 7.89e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 132 FEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPMLMVTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARG 211
Cdd:pfam02601   1 FDPNRKRPLPRLPKRIGVITSPTGAAIRDILTTLNRRFPLVEVLLYPALVQGEGAAASIAAAIRLANARPEFDVLIIGRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 212 GGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDFAADLRAPTPTAAAEMATQVsINDIKVQIGEIYFQLVVAI 291
Cdd:pfam02601  81 GGSLEDLWAFNEEAVARAIAASPIPVISGVGHETDFTIADFVADLRAPTPTAAAELAVPD-RAELLARLEQLQQRLRRAM 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 292 REIQNQKRSEMRECRNRLQncSPARRIQSSWQGLDTMTRRMITAQRHRLSLETIRlhgvVENLSSLNPLDVLKRGYAVVt 371
Cdd:pfam02601 160 QRRLERRRQRLDRLARRLP--SPSRLLERQRQRLDELAQRLQRALARRLARRRQR----AARLEALSPLAVLARGYAIV- 232
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1084523958 372 RSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQ 403
Cdd:pfam02601 233 RDQDGKVVRSAAQLKPGDELTIRLADGEVDAT 264
ExoVII_LU_OBF cd04489
ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of ...
34-111 1.34e-38

ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-specific exonuclease which degrades ssDNA from both 3-prime and 5-prime ends. ExoVII plays a role in methyl-directed mismatch repair in vivo. ExoVII may also guard the genome from mutagenesis by removing excess ssDNA, since the build up of ssDNA would lead to SOS induction and PolIV-dependent mutagenesis.


Pssm-ID: 239935 [Multi-domain]  Cd Length: 78  Bit Score: 133.41  E-value: 1.34e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084523958  34 DVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNINVYEAGGQYQLNTDSIRSKG 111
Cdd:cd04489     1 RVWVEGEISNLKRPSSGHLYFTLKDEDASIRCVMWRSNARRLGFPLEEGMEVLVRGKVSFYEPRGGYQLIVEEIEPAG 78
 
Name Accession Description Interval E-value
XseA COG1570
Exonuclease VII, large subunit [Replication, recombination and repair];
13-406 0e+00

Exonuclease VII, large subunit [Replication, recombination and repair];


Pssm-ID: 441178 [Multi-domain]  Cd Length: 400  Bit Score: 525.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  13 LSVTDLTRYLRQLMESDeiLQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNIN 92
Cdd:COG1570     6 LSVSELNRYIKRLLERD--FGNVWVEGEISNLKRHSSGHLYFTLKDEDAQIRCVMFRGRARRLKFRPEDGMKVLVRGRVS 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  93 VYEAGGQYQLNTDSIRSKGEGVLYQEFIRLKNLLEAEGFFEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPML 172
Cdd:COG1570    84 VYEPRGDYQLIVEDIEPAGLGALLAAFEQLKEKLAAEGLFDPERKRPLPFLPRRIGVVTSPTGAAIRDILTVLRRRFPAV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 173 MVTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARGGGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDF 252
Cdd:COG1570   164 EVLLYPVLVQGEGAAAEIAAAIERANARPEVDVIIVARGGGSLEDLWAFNDEAVARAIAASPIPVISAVGHETDFTIADF 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 253 AADLRAPTPTAAAEMATQVsINDIKVQIGEIYFQLVVAIREIQNQKRSEMRECRNRLQNCSPARRIQSSWQGLDTMTRRM 332
Cdd:COG1570   244 VADLRAPTPTAAAELAVPD-RAELLARLDQLRARLRRALRRRLERERQRLDRLRRRLVLASPERLLEQRRQRLDELEQRL 322
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084523958 333 ITAQRHRLSLETIRLHGVVENLSSLNPLDVLKRGYAVVtRSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQVSG 406
Cdd:COG1570   323 RRALRRRLERKRQRLEALAARLEALSPLATLARGYAIV-RDADGKVVRSAAQVKPGDRLTIRLADGELEATVTE 395
xseA TIGR00237
exodeoxyribonuclease VII, large subunit; This family consist of exodeoxyribonuclease VII, ...
14-404 0e+00

exodeoxyribonuclease VII, large subunit; This family consist of exodeoxyribonuclease VII, large subunit XseA which catalyses exonucleolytic cleavage in either the 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. Exonuclease VII consists of one large subunit and four small subunits. [DNA metabolism, Degradation of DNA]


Pssm-ID: 272979 [Multi-domain]  Cd Length: 389  Bit Score: 515.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  14 SVTDLTRYLRQLMESDeILQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNINV 93
Cdd:TIGR00237   1 SVSELNRYIKELLERD-FLPNVWVEGEISNLKRHSSGHLYFTLKDEKAQIRCVMFRSRARRLKFRPEEGMKVLVRGRVSV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  94 YEAGGQYQLNTDSIRSKGEGVLYQEFIRLKNLLEAEGFFEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPMLM 173
Cdd:TIGR00237  80 YEPRGSYQLIVEDIEPAGLGELYLAFEQLKEKLAAEGLFDPERKKPLPRFPKRIGVITSPTGAAIRDILNVLRRRWPLVE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 174 VTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARGGGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDFA 253
Cdd:TIGR00237 160 IVLYPALVQGEGAAASIIAAIERLNARGDVDVIIIGRGGGSIEDLWAFNDEAVARAIAASPIPVISAVGHETDFTIADFV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 254 ADLRAPTPTAAAEMATQvSINDIKVQIGEIYFQLVVAIREIQNQKRSEMRECRNRLQNCSPARRIQSSWQGLDTMTRRMI 333
Cdd:TIGR00237 240 ADLRAPTPTAAAELAVP-DRAELLQRLDQLRERLRRALQRRLERERQRLDRLRSRLVLASPERLLERQRQRLDRLEQRLK 318
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1084523958 334 TAQRHRLSLETIRLHGVVENLSSLNPLDVLKRGYAVVtRSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQV 404
Cdd:TIGR00237 319 RALRRRLERKRQRLELLAARLEALSPLATLKRGYAIV-RDEDGKVVRSAKQLKPGDELTIRLADGEIKARV 388
Exonuc_VII_L pfam02601
Exonuclease VII, large subunit; This family consist of exonuclease VII, large subunit EC:3.1. ...
132-403 7.89e-112

Exonuclease VII, large subunit; This family consist of exonuclease VII, large subunit EC:3.1.11.6 This enzyme catalyzes exonucleolytic cleavage in either 5'->3' or 3'->5' direction to yield 5'-phosphomononucleotides. This exonuclease VII enzyme is composed of one large subunit and 4 small ones.


Pssm-ID: 426865  Cd Length: 264  Bit Score: 328.62  E-value: 7.89e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 132 FEVERKRSIPEFVKRIGIVTSPTGAALRDMINTLRRRNPMLMVTLAGSAVQGEGAPDGLVSAIQSLNRLVHPDLILLARG 211
Cdd:pfam02601   1 FDPNRKRPLPRLPKRIGVITSPTGAAIRDILTTLNRRFPLVEVLLYPALVQGEGAAASIAAAIRLANARPEFDVLIIGRG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 212 GGSIEDLWAFNDERVVRAIVASEAPIITGVGHETDFTLSDFAADLRAPTPTAAAEMATQVsINDIKVQIGEIYFQLVVAI 291
Cdd:pfam02601  81 GGSLEDLWAFNEEAVARAIAASPIPVISGVGHETDFTIADFVADLRAPTPTAAAELAVPD-RAELLARLEQLQQRLRRAM 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958 292 REIQNQKRSEMRECRNRLQncSPARRIQSSWQGLDTMTRRMITAQRHRLSLETIRlhgvVENLSSLNPLDVLKRGYAVVt 371
Cdd:pfam02601 160 QRRLERRRQRLDRLARRLP--SPSRLLERQRQRLDELAQRLQRALARRLARRRQR----AARLEALSPLAVLARGYAIV- 232
                         250       260       270
                  ....*....|....*....|....*....|..
gi 1084523958 372 RSPDNRLITQTEQVEVGDQLTVRVKNGSFPVQ 403
Cdd:pfam02601 233 RDQDGKVVRSAAQLKPGDELTIRLADGEVDAT 264
tRNA_anti_2 pfam13742
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ...
13-108 1.92e-43

OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids.


Pssm-ID: 463974 [Multi-domain]  Cd Length: 95  Bit Score: 146.83  E-value: 1.92e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523958  13 LSVTDLTRYLRQLMEsDEILQDVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNIN 92
Cdd:pfam13742   1 LSVSELNRYIKDLLE-PALPGAVWVEGEISNLKRRSSGHLYFTLKDEKAQIRCVMFRSRARRLKFTPEDGMKVLVRGRVS 79
                          90
                  ....*....|....*.
gi 1084523958  93 VYEAGGQYQLNTDSIR 108
Cdd:pfam13742  80 VYEPRGSYQLIVEDIE 95
ExoVII_LU_OBF cd04489
ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of ...
34-111 1.34e-38

ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-specific exonuclease which degrades ssDNA from both 3-prime and 5-prime ends. ExoVII plays a role in methyl-directed mismatch repair in vivo. ExoVII may also guard the genome from mutagenesis by removing excess ssDNA, since the build up of ssDNA would lead to SOS induction and PolIV-dependent mutagenesis.


Pssm-ID: 239935 [Multi-domain]  Cd Length: 78  Bit Score: 133.41  E-value: 1.34e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1084523958  34 DVWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNINVYEAGGQYQLNTDSIRSKG 111
Cdd:cd04489     1 RVWVEGEISNLKRPSSGHLYFTLKDEDASIRCVMWRSNARRLGFPLEEGMEVLVRGKVSFYEPRGGYQLIVEEIEPAG 78
tRNA_anti-codon pfam01336
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ...
35-108 1.41e-13

OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.


Pssm-ID: 460164 [Multi-domain]  Cd Length: 75  Bit Score: 65.33  E-value: 1.41e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1084523958  35 VWVQGEISNLTRPASGHIYFTLKDSGASLRCVMWRSNITRLKTALQDGMAVEAHGNINVYEaGGQYQLNTDSIR 108
Cdd:pfam01336   1 VTVAGRVTSIRRSGGKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRK-GGELELVVEEIE 73
RPA2_OBF_family cd03524
RPA2_OBF_family: A family of oligonucleotide binding (OB) folds with similarity to the OB fold ...
37-108 6.97e-03

RPA2_OBF_family: A family of oligonucleotide binding (OB) folds with similarity to the OB fold of the single strand (ss) DNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears to be involved in all aspects of DNA metabolism including replication, recombination, and repair. RPA also mediates specific interactions of various nuclear proteins. In animals, plants, and fungi, RPA is a heterotrimer with subunits of 70KDa (RPA1), 32kDa (RPA2), and 14 KDa (RPA3). RPA contains six OB folds, which are involved in ssDNA binding and in trimerization. The ssDNA binding mechanism is believed to be multistep and to involve conformational change. This family also includes OB folds similar to those found in Escherichia coli SSB, the wedge domain of E. coli RecG (a branched-DNA-specific helicase), E. coli ssDNA specific exodeoxyribonuclease VII large subunit, Pyrococcus abyssi DNA polymerase II (Pol II) small subunit, Sulfolobus solfataricus SSB, and Bacillus subtilis YhaM (a 3'-to-5'exoribonuclease). It also includes the OB folds of breast cancer susceptibility gene 2 protein (BRCA2), Oxytricha nova telomere end binding protein (TEBP), Saccharomyces cerevisiae telomere-binding protein (Cdc13), and human protection of telomeres 1 protein (POT1).


Pssm-ID: 239601 [Multi-domain]  Cd Length: 75  Bit Score: 35.03  E-value: 6.97e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1084523958  37 VQGEISNL--TRPASGHIYFTLKD-SGASLRCVMWRSNITRLKTALQDGMAVEAHGNINVYeaGGQYQLNTDSIR 108
Cdd:cd03524     2 IVGIVVAVeeIRTEGKVLIFTLTDgTGGTIRVTLFGELAEELENLLKEGQVVYIKGKVKKF--RGRLQLIVESIE 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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