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Conserved domains on  [gi|1084523943|gb|OGN85745|]
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hypothetical protein A2X27_01070 [Chloroflexi bacterium GWD2_49_16]

Protein Classification

DMT family transporter( domain architecture ID 11430850)

DMT (drug/metabolite transporter) family transporter is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others

Gene Ontology:  GO:0016020|GO:0055085|GO:0022857
PubMed:  11432728
TCDB:  2.A.7

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
11-289 1.48e-38

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


:

Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 137.28  E-value: 1.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  11 KFLPYIALATGILALSLTAMFVRWA--DAPATITGFYRLLITSLILLPLFTWKNSKNNRITRRNLIFPILGGLF-TAFDF 87
Cdd:COG0697     1 RLRGILLLLLAALLWGSSFVAIKLAlaGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLgLALAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  88 AFWNSSVLYTTASNATLLGNTAPIWVALVTIFIFRHRLPKGFWFGLTLTLGGAALVLGNDFIIHPRLGMGDLMALAAGFF 167
Cdd:COG0697    81 LLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLGDLLALLAALS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 168 YAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILGFPFSgYSQQSWLVFLALALVSQILGYMSVSYALGHLPASV 247
Cdd:COG0697   161 WALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLP-LSAAAWLALLYLGLFGTALAYLLWFRALRRLGASR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1084523943 248 VAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:COG0697   240 AAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLA 281
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
11-289 1.48e-38

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 137.28  E-value: 1.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  11 KFLPYIALATGILALSLTAMFVRWA--DAPATITGFYRLLITSLILLPLFTWKNSKNNRITRRNLIFPILGGLF-TAFDF 87
Cdd:COG0697     1 RLRGILLLLLAALLWGSSFVAIKLAlaGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLgLALAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  88 AFWNSSVLYTTASNATLLGNTAPIWVALVTIFIFRHRLPKGFWFGLTLTLGGAALVLGNDFIIHPRLGMGDLMALAAGFF 167
Cdd:COG0697    81 LLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLGDLLALLAALS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 168 YAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILGFPFSgYSQQSWLVFLALALVSQILGYMSVSYALGHLPASV 247
Cdd:COG0697   161 WALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLP-LSAAAWLALLYLGLFGTALAYLLWFRALRRLGASR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1084523943 248 VAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:COG0697   240 AAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLA 281
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
155-289 2.81e-10

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 57.20  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 155 GMGDLMALAAGFFYAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILGFPFSgYSQQSWLVFLALALVSQILGYM 234
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLV-IPLKSWLALLYLGVLGTFLGFL 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1084523943 235 SVSYALGHLPASVVAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:pfam00892  80 LYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
 
Name Accession Description Interval E-value
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
11-289 1.48e-38

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 137.28  E-value: 1.48e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  11 KFLPYIALATGILALSLTAMFVRWA--DAPATITGFYRLLITSLILLPLFTWKNSKNNRITRRNLIFPILGGLF-TAFDF 87
Cdd:COG0697     1 RLRGILLLLLAALLWGSSFVAIKLAlaGLPPLQLAFLRFLLAALLLLPLLLLRGRRLPPLSRRDWLLLLLRGLLgLALAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  88 AFWNSSVLYTTASNATLLGNTAPIWVALVTIFIFRHRLPKGFWFGLTLTLGGAALVLGNDFIIHPRLGMGDLMALAAGFF 167
Cdd:COG0697    81 LLFFLALQYTPAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGGGGSLLGDLLALLAALS 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 168 YAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILGFPFSgYSQQSWLVFLALALVSQILGYMSVSYALGHLPASV 247
Cdd:COG0697   161 WALYTVLTRRLSRRLDPLTLTFWQMLVGALLLLPLALLTGLPLP-LSAAAWLALLYLGLFGTALAYLLWFRALRRLGASR 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1084523943 248 VAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:COG0697   240 AAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLA 281
RhtA COG5006
Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];
8-289 2.62e-20

Threonine/homoserine efflux transporter RhtA [Amino acid transport and metabolism];


Pssm-ID: 444030 [Multi-domain]  Cd Length: 290  Bit Score: 88.34  E-value: 2.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943   8 KSSKFLPYIALATGILALSLTAMFVRW--ADAPATITGFYRLLITSLILLPLFtwkNSKNNRITRRNLIFPILGGLFTAF 85
Cdd:COG5006     4 SSSRLPGVLLVLLSALSVQLGAALAKLlfPGVGPLGVTALRLAFAALILLLIF---RPWRRRLTRRDWLALLLYGVALAG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  86 DFAFWNSSVLYTTASNATLLGNTAPIWVALVTififRHRLPKGFWFGLTLtlGGAALVLGNDFIIHPRLGMGDLMALAAG 165
Cdd:COG5006    81 MNLLFYLAIARIPLGIAVALEFLGPLAVALLG----SRRRRDLLWVALAL--AGVVLLLPVGLSGGSLDPVGVLFALGAA 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 166 FFYAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLIlGFPFSGYSQQSWLVFLALALVSQILGYMSVSYALGHLPA 245
Cdd:COG5006   155 ACWALYILLGRRVGARLPGLTGLALGMLVAALVLLPFGLP-TAGPALLDPPVLLLGLGVAVLSSVLPYSLEMVALRRLPA 233
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1084523943 246 SVVAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:COG5006   234 RTFGILMSLEPAVAALAGWLVLGEVLTPLQWLGIALVVAASAGA 277
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
155-289 2.81e-10

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 57.20  E-value: 2.81e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 155 GMGDLMALAAGFFYAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILGFPFSgYSQQSWLVFLALALVSQILGYM 234
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLV-IPLKSWLALLYLGVLGTFLGFL 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1084523943 235 SVSYALGHLPASVVAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:pfam00892  80 LYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLI 134
RibN COG2510
Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];
156-289 1.23e-08

Riboflavin transporter RibN, EamA domain [Coenzyme transport and metabolism];


Pssm-ID: 442000  Cd Length: 138  Bit Score: 52.88  E-value: 1.23e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943 156 MGDLMALAAGFFYAGYLLSTQRGRESLDPLSYMTIMVISASLFSLFINLILG--FPFSGYSQQSWLvFLALALVSQILGY 233
Cdd:COG2510     1 SWLLLALLSAFFAGLTAIFAKIGLKGIDPNLATFIRTLVALIFLLLILLVTGklGELPELSPKSWL-FLLLSGLATGLSW 79
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1084523943 234 MSVSYALGHLPASVVAPTMIGQPILTTLLAIPLLGELPQSIQLIGGMITLAGIYLV 289
Cdd:COG2510    80 LFYFRALKLGPASIVAPIDKLSPVFTVLLSVLFLGERLTLKQIIGILLIVAGVILL 135
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
15-144 2.93e-06

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 46.03  E-value: 2.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1084523943  15 YIALATGILALSLTAMFVRWADAPATITGFYRLLITSLILLPLFTWKNSKNNRITRRNLIFPILGGLFTAFDFAFWNSSV 94
Cdd:pfam00892   6 LALLAALIWAIYFVFSKILLRRISPLTLTFWRFLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYFYGL 85
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1084523943  95 LYTTASNATLLGNTAPIWVALVTIFIFRHRLPKGFWFGLTLTLGGAALVL 144
Cdd:pfam00892  86 KYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLLIL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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